| Year |
Citation |
Score |
| 2024 |
Yang Y, Valdés-Rives SA, Liu Q, Li Y, Tan J, Tan Y, Koch CA, Rong Y, Houser SR, Wei S, Cai KQ, Cheng SY, Curran T, Wechsler-Reya R, Yang ZJ. Thyroid Hormone Suppresses Medulloblastoma Progression Through Promoting Terminal Differentiation of Tumor Cells. Biorxiv : the Preprint Server For Biology. PMID 38405864 DOI: 10.1101/2024.02.13.580111 |
0.362 |
|
| 2024 |
Gold MP, Ong W, Masteller AM, Ghasemi DR, Galindo JA, Park NR, Huynh NC, Donde A, Pister V, Saurez RA, Vladoiu MC, Hwang GH, Eisemann T, Donovan LK, Walker AD, ... ... Wechsler-Reya RJ, et al. Developmental basis of SHH medulloblastoma heterogeneity. Nature Communications. 15: 270. PMID 38191555 DOI: 10.1038/s41467-023-44300-0 |
0.345 |
|
| 2023 |
Chapman OS, Luebeck J, Sridhar S, Wong IT, Dixit D, Wang S, Prasad G, Rajkumar U, Pagadala MS, Larson JD, He BJ, Hung KL, Lange JT, Dehkordi SR, Chandran S, ... ... Wechsler-Reya RJ, et al. Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma. Nature Genetics. PMID 37945900 DOI: 10.1038/s41588-023-01551-3 |
0.325 |
|
| 2023 |
Rajbhandari N, Hamilton M, Quintero CM, Ferguson LP, Fox R, Schürch CM, Wang J, Nakamura M, Lytle NK, McDermott M, Diaz E, Pettit H, Kritzik M, Han H, Cridebring D, ... ... Wechsler-Reya RJ, et al. Single-cell mapping identifies MSI cells as a common origin for diverse subtypes of pancreatic cancer. Cancer Cell. PMID 37802055 DOI: 10.1016/j.ccell.2023.09.008 |
0.389 |
|
| 2022 |
Kuzuoglu-Ozturk D, Aksoy O, Schmidt C, Lea R, Larson JD, Phelps RRL, Nasholm N, Holt M, Contreras A, Huang M, Wong-Michalak S, Shao H, Wechsler-Reya R, Phillips JJ, Gestwicki JE, et al. N-myc mediated translation control is a therapeutic vulnerability in medulloblastoma. Cancer Research. PMID 36264168 DOI: 10.1158/0008-5472.CAN-22-0945 |
0.308 |
|
| 2022 |
Borgenvik A, Holmberg KO, Bolin S, Zhao M, Savov V, Rosén G, Hutter S, Garancher A, Suryo Rahmanto A, Bergström T, Olsen TK, Mainwaring OJ, Sattanino D, Verbaan AD, Rusert JM, ... ... Wechsler-Reya RJ, et al. Dormant SOX9-positive cells facilitate MYC-driven recurrence of medulloblastoma. Cancer Research. PMID 36219398 DOI: 10.1158/0008-5472.CAN-22-2108 |
0.434 |
|
| 2022 |
Foster JB, Griffin C, Rokita JL, Stern A, Brimley C, Rathi K, Lane MV, Buongervino SN, Smith T, Madsen PJ, Martinez D, Delaidelli A, Sorensen PH, Wechsler-Reya RJ, Karikó K, et al. Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors. Journal For Immunotherapy of Cancer. 10. PMID 36167467 DOI: 10.1136/jitc-2021-004450 |
0.344 |
|
| 2022 |
Hendrikse LD, Haldipur P, Saulnier O, Millman J, Sjoboen AH, Erickson AW, Ong W, Gordon V, Coudière-Morrison L, Mercier AL, Shokouhian M, Suárez RA, Ly M, Borlase S, Scott DS, ... ... Wechsler-Reya RJ, et al. Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. PMID 36131014 DOI: 10.1038/s41586-022-05215-w |
0.313 |
|
| 2022 |
Leskoske KL, Garcia-Mansfield K, Sharma R, Krishnan A, Rusert JM, Mesirov JP, Wechsler-Reya RJ, Pirrotte P. Subgroup-Enriched Pathways and Kinase Signatures in Medulloblastoma Patient-Derived Xenografts. Journal of Proteome Research. PMID 35977718 DOI: 10.1021/acs.jproteome.2c00203 |
0.306 |
|
| 2022 |
Zagozewski J, Borlase S, Guppy BJ, Coudière-Morrison L, Shahriary GM, Gordon V, Liang L, Cheng S, Porter CJ, Kelley R, Hawkins C, Chan JA, Liang Y, Gong J, Nör C, ... ... Wechsler-Reya RJ, et al. Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression. Communications Biology. 5: 697. PMID 35835937 DOI: 10.1038/s42003-022-03654-9 |
0.352 |
|
| 2022 |
Li Q, Han Z, Singh N, Terré B, Fame RM, Arif U, Page TD, Zahran T, Abdeltawab A, Huang Y, Cao P, Wang J, Lu H, Lidov HGW, Surendran K, ... ... Wechsler-Reya RJ, et al. Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development. Cell Death and Differentiation. PMID 35322202 DOI: 10.1038/s41418-022-00950-z |
0.443 |
|
| 2021 |
Banerjee S, Yoon H, Ting S, Tang CM, Yebra M, Wenzel AT, Yeerna H, Mesirov JP, Wechsler-Reya RJ, Tamayo P, Sicklick JK. KIT Low Cells Mediate Imatinib Resistance in Gastrointestinal Stromal Tumor. Molecular Cancer Therapeutics. PMID 34376580 DOI: 10.1158/1535-7163.MCT-20-0973 |
0.418 |
|
| 2021 |
Qiu R, Wu J, Gudenas B, Northcott PA, Wechsler-Reya RJ, Lu Q. Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth. Communications Biology. 4: 552. PMID 33976373 DOI: 10.1038/s42003-021-02075-4 |
0.555 |
|
| 2020 |
Rusert JM, Juarez EF, Brabetz S, Jensen J, Garancher A, Chau LQ, Tacheva-Grigorova SK, Wahab S, Udaka YT, Finlay D, Seker-Cin H, Reardon B, Gröbner S, Serrano J, Ecker J, ... ... Wechsler-Reya RJ, et al. Functional precision medicine identifies new therapeutic candidates for medulloblastoma. Cancer Research. PMID 33046443 DOI: 10.1158/0008-5472.CAN-20-1655 |
0.306 |
|
| 2020 |
Ecker J, Thatikonda V, Sigismondo G, Selt F, Valinciute G, Oehme I, Müller C, Buhl JL, Ridinger J, Usta D, Qin N, van Tilburg CM, Herold-Mende C, Remke M, Sahm F, ... ... Wechsler-Reya RJ, et al. Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma. Neuro-Oncology. PMID 32822486 DOI: 10.1093/Neuonc/Noaa191 |
0.306 |
|
| 2020 |
Cheng Y, Liao S, Xu G, Hu J, Guo D, Du F, Contreras A, Cai KQ, Peri S, Wang Y, Corney DC, Noronha AM, Chau LQ, Zhou G, Wiest DL, ... ... Wechsler-Reya RJ, et al. NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma. Cell Reports. 31: 107782. PMID 32579914 DOI: 10.1016/J.Celrep.2020.107782 |
0.784 |
|
| 2020 |
Garancher A, Suzuki H, Haricharan S, Chau LQ, Masihi MB, Rusert JM, Norris PS, Carrette F, Romero MM, Morrissy SA, Skowron P, Cavalli FMG, Farooq H, Ramaswamy V, Jones SJM, ... ... Wechsler-Reya RJ, et al. Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma. Nature Neuroscience. PMID 32424282 DOI: 10.1038/S41593-020-0628-4 |
0.452 |
|
| 2020 |
Garancher A, Suzuki H, Haricharan S, Masihi MB, Rusert JM, Norris PS, Carrette F, Romero MM, Morrissy SA, Skowron P, Cavalli FMG, Farooq H, Ramaswamy V, Morcavallo A, Henderson JJ, ... ... Wechsler-Reya RJ, et al. Abstract IA11: Overcoming immune evasion in pediatric brain tumors Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-Ia11 |
0.45 |
|
| 2020 |
Yeerna H, Briggs B, Rusert J, Chavez L, Mesirov J, Wechsler-Reya R, Tamayo P. Abstract B21: Childhood Cancer Molecular Map (C2M2) to define medulloblastoma heterogeneity and predict treatment response Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-B21 |
0.36 |
|
| 2020 |
Prabhu VV, Morrow S, Cuoco CA, Kawakibi AR, Jung J, Madhukar N, Garnett MJ, McDermott U, Benes CH, Wechsler-Reya R, Anantharaman L, Charter N, Rucker JB, Doranz BJ, Basken J, et al. Abstract 5688: IND-enabling characterization of ONC206 as the next bitopic antagonist for oncology Cancer Research. 80: 5688-5688. DOI: 10.1158/1538-7445.Am2020-5688 |
0.368 |
|
| 2020 |
Katsushima K, Joshi P, Stapleton S, Garancher A, Vibhakar R, Raabe E, Eberhart C, Wechsler-Reya R, Jallo G, Perera R. MBRS-16. MYC REGULATED LONG NONCODING RNA LNC-HLX-2–7 IS A PUTATIVE MOLECULAR MARKER AND A THERAPEUTIC TARGET FOR GROUP 3 MEDULLOBLASTOMAS IN CHILDREN Neuro-Oncology. 22: iii401-iii401. DOI: 10.1093/neuonc/noaa222.532 |
0.306 |
|
| 2020 |
Masihi MB, Lee C, Furnari GA, Garancher A, Wechsler-Reya RJ. MBRS-12. A TRANSPOSON MUTAGENESIS SCREEN IDENTIFIES Rreb1 AS A DRIVER FOR GROUP 3 MEDULLOBLASTOMA Neuro-Oncology. 22: iii400-iii400. DOI: 10.1093/neuonc/noaa222.529 |
0.331 |
|
| 2020 |
Bolin S, Savov V, Borgenvik A, Rosén G, Olausson KH, Zhao M, Garancher A, Rahmanto AS, Hutter S, Mainwaring O, Rusert J, Sundstrom A, Richardson S, Fotaki G, Hill RM, ... ... Wechsler-Reya RJ, et al. MBRS-10. QUIESCENT SOX9-POSITIVE CELLS BEHIND MYC DRIVEN MEDULLOBLASTOMA RECURRENCE Neuro-Oncology. 22: iii400-iii400. DOI: 10.1093/neuonc/noaa222.528 |
0.416 |
|
| 2020 |
Okonechnikov K, Hübner J, Chapman O, Chakraborty A, Pagadala M, Bump R, Chandran S, Kraft K, Hidalgo RA, Mundlos S, Wechsler-Reya R, Juarez EF, Coufal N, Levy M, Crawford J, et al. EPEN-04. ONCOGENIC 3D TUMOR GENOME ORGANIZATION IDENTIFIES NEW THERAPEUTIC TARGETS IN EPENDYMOMA Neuro-Oncology. 22: iii308-iii308. DOI: 10.1093/neuonc/noaa222.145 |
0.324 |
|
| 2020 |
Beigi Masihi M, Lee C, Garancher A, Furnari G, Wechsler-Reya R. TMOD-30. IDENTIFYING NEW DRIVERS OF GROUP 3 MEDULLOBLASTOMA Neuro-Oncology. 22: ii234-ii234. DOI: 10.1093/neuonc/noaa215.980 |
0.376 |
|
| 2020 |
Koga T, Miki S, Skinner KR, Venneti S, Malicki D, Wechsler-Reya R, Gruener R, Huang RS, Chen C, Miller CR, Furnari F. TMOD-07. HUMAN DIFFUSE MIDLINE GLIOMA AVATARS AS A PLATFORM TO SEARCH FOR NOVEL THERAPEUTIC TARGETS Neuro-Oncology. 22: ii229-ii229. DOI: 10.1093/neuonc/noaa215.958 |
0.314 |
|
| 2020 |
Eisemann T, Wechsler-Reya R. IMMU-48. CD4+ T CELLS RESTRICT MEDULLOBLASTOMA GROWTH AND DISSEMINATION Neuro-Oncology. 22: ii115-ii115. DOI: 10.1093/neuonc/noaa215.478 |
0.311 |
|
| 2019 |
Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, ... ... Wechsler-Reya RJ, et al. Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αβ Axis. Cell Stem Cell. PMID 31956038 DOI: 10.1016/J.Stem.2019.11.016 |
0.428 |
|
| 2019 |
Čančer M, Hutter S, Holmberg KO, Rosén G, Sundström A, Tailor J, Bergström T, Garancher A, Essand M, Wechsler-Reya RJ, Falk A, Weishaupt H, Swartling FJ. Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy. Cell Stem Cell. 25: 855-870.e11. PMID 31786016 DOI: 10.1016/J.Stem.2019.10.005 |
0.535 |
|
| 2019 |
Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, ... ... Wechsler-Reya RJ, et al. Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma. Nature. 574: 707-711. PMID 31664194 DOI: 10.1038/S41586-019-1650-0 |
0.343 |
|
| 2019 |
Tokita MJ, Nahas S, Briggs B, Malicki DM, Mesirov JP, Reyes IAC, Farnaes L, Levy ML, Kingsmore SF, Dimmock D, Crawford JR, Wechsler-Reya RJ. Biallelic loss of GNAS in a patient with pediatric medulloblastoma. Cold Spring Harbor Molecular Case Studies. PMID 31624069 DOI: 10.1101/mcs.a004572 |
0.307 |
|
| 2019 |
Chahal KK, Li J, Kufareva I, Parle M, Durden DL, Wechsler-Reya RJ, Chen CC, Abagyan R. Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. Plos One. 14: e0214901. PMID 31539380 DOI: 10.1371/Journal.Pone.0214901 |
0.451 |
|
| 2019 |
Hovestadt V, Smith KS, Bihannic L, Filbin MG, Shaw ML, Baumgartner A, DeWitt JC, Groves A, Mayr L, Weisman HR, Richman AR, Shore ME, Goumnerova L, Rosencrance C, Carter RA, ... ... Wechsler-Reya RJ, et al. Resolving medulloblastoma cellular architecture by single-cell genomics. Nature. PMID 31341285 DOI: 10.1038/S41586-019-1434-6 |
0.376 |
|
| 2019 |
Pace J, Teske KA, Chau L, Dash RC, Zaino AM, Wechsler-Reya R, Hadden MK. Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors. Journal of Medicinal Chemistry. PMID 30896941 DOI: 10.1021/Acs.Jmedchem.8B01283 |
0.308 |
|
| 2019 |
Wang J, Merino DM, Light N, Murphy BL, Wang YD, Guo X, Hodges AP, Chau LQ, Liu KW, Dhall G, Asgharzadeh S, Kiehna EN, Shirey RJ, Janda KD, Taylor MD, ... ... Wechsler-Reya RJ, et al. Myc and loss of p53 cooperate to drive formation of choroid plexus carcinoma. Cancer Research. PMID 30885981 DOI: 10.1158/0008-5472.Can-18-2565 |
0.529 |
|
| 2019 |
Beckmann PJ, Larson JD, Larsson AT, Ostergaard JP, Wagner S, Rahrmann EP, Shamsan GA, Otto GM, Williams RL, Wang J, Lee C, Tschida BR, Das P, Dubuc AM, Moriarity BS, ... ... Wechsler-Reya RJ, et al. Sleeping Beauty insertional mutagenesis reveals important genetic drivers of central nervous system embryonal tumors. Cancer Research. PMID 30674530 DOI: 10.1158/0008-5472.Can-18-1261 |
0.491 |
|
| 2019 |
Lee C, Rudneva VA, Erkek S, Zapatka M, Chau LQ, Tacheva-Grigorova SK, Garancher A, Rusert JM, Aksoy O, Lea R, Mohammad HP, Wang J, Weiss WA, Grimes HL, Pfister SM, ... ... Wechsler-Reya RJ, et al. Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma. Nature Communications. 10: 332. PMID 30659187 DOI: 10.1038/S41467-018-08269-5 |
0.448 |
|
| 2019 |
Teske KA, Dash RC, Morel SR, Chau LQ, Wechsler-Reya RJ, Hadden MK. Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors. European Journal of Medicinal Chemistry. 163: 320-332. PMID 30529635 DOI: 10.1016/J.Ejmech.2018.11.056 |
0.333 |
|
| 2019 |
Prabhu VV, Kawakibi AR, Madhukar N, Garnett MJ, McDermott U, Benes CH, Anantharaman L, Charter N, Deacon S, VanEngelenburg A, Rucker JB, Doranz BJ, Rusert J, Wechsler-Reya R, Elemento O, et al. Abstract 3877: IND-enabling characterization of DRD2/3 imipridone antagonist ONC206 for oncology Cancer Research. 79: 3877-3877. DOI: 10.1158/1538-7445.Sabcs18-3877 |
0.327 |
|
| 2019 |
Banerjee S, Tang C, Yebra M, Medetgul K, Burgoyne AM, Tamayo P, Wechsler-Reya R, Sicklick JK. Abstract 263: KITlowcells mediate Imatinib resistance and disease persistence in gastrointestinal stromal tumor Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-263 |
0.374 |
|
| 2019 |
Bihannic L, Hovestadt V, Smith K, Filbin M, Shaw M, Baumgartner A, DeWitt J, Groves A, Mayr L, Weisman H, Richman A, Shore M, Goumnerova L, Rosencrance C, Carter R, ... ... Wechsler-Reya R, et al. PDTM-32. RESOLVING MEDULLOBLASTOMA CELLULAR ARCHITECTURE BY SINGLE-CELL GENOMICS Neuro-Oncology. 21: vi194-vi194. DOI: 10.1093/Neuonc/Noz175.808 |
0.477 |
|
| 2019 |
Prabhu V, Rahman Kawakibi A, Madhukar N, Garnett M, McDermott U, Benes C, Wechsler-Reya R, Elemento O, Stogniew M, Oster W, DeMorrow S, Allen J. EXTH-71. IND-ENABLING CHARACTERIZATION OF ONC206 AS THE NEXT BITOPIC DRD2 ANTAGONIST FOR NEURO-ONCOLOGY Neuro-Oncology. 21: vi97-vi97. DOI: 10.1093/Neuonc/Noz175.401 |
0.336 |
|
| 2019 |
Koga T, Chaim I, Markmiller S, Benitez J, Parisian A, Miki S, Hessenauer F, Turner K, Venneti S, Malicki D, Wechsler-Reya R, Mischel P, Chen C, Yeo G, Furnari F. TMOD-28. AUTHENTIC HUMAN GLIOMA MODELING USING GENETICALLY ENGINEERED INDUCED PLURIPOTENT STEM CELLS Neuro-Oncology. 21: vi268-vi269. DOI: 10.1093/Neuonc/Noz175.1127 |
0.515 |
|
| 2019 |
Bolin S, Savov V, Borgenvik A, Rosen G, Garancher A, Rahmanto AS, Hutter S, Mainwaring O, Olausson KH, Rusert J, Sundstrom A, Richardson S, Fotaki G, Hill R, Dubuc A, ... ... Wechsler-Reya R, et al. MEDU-26. LATENT SOX9-POSITIVE CELLS RESPONSIBLE FOR MYC-DRIVEN MEDULLOBLASTOMA RECURRENCE Neuro-Oncology. 21: ii108-ii109. DOI: 10.1093/Neuonc/Noz036.185 |
0.522 |
|
| 2019 |
Garancher A, Suzuki H, Haricharan S, Masihi MB, Rusert JM, Norris PS, Carrette F, Romero MM, Morrissy SA, Skowron P, M.G. Cavalli F, Farooq H, Ramaswamy V, J.M. Jones S, Moore RA, ... ... Wechsler-Reya RJ, et al. IMMU-03. TUMOR NECROSIS FACTOR OVERCOMES IMMUNE EVASION IN P53-MUTANT MEDULLOBLASTOMA Neuro-Oncology. 21: ii93-ii93. DOI: 10.1093/Neuonc/Noz036.124 |
0.348 |
|
| 2018 |
Maschinot CA, Chau LQ, Wechsler-Reya RJ, Hadden MK. Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling. European Journal of Medicinal Chemistry. 162: 495-506. PMID 30471551 DOI: 10.1016/J.Ejmech.2018.11.028 |
0.302 |
|
| 2018 |
Kahn SA, Wang X, Nitta RT, Gholamin S, Theruvath J, Hutter G, Azad TD, Wadi L, Bolin S, Ramaswamy V, Esparza R, Liu KW, Edwards M, Swartling FJ, Sahoo D, ... ... Wechsler-Reya RJ, et al. Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma. Nature Communications. 9: 4121. PMID 30297829 DOI: 10.1038/S41467-018-06564-9 |
0.389 |
|
| 2018 |
Purzner T, Purzner J, Buckstaff T, Cozza G, Gholamin S, Rusert JM, Hartl TA, Sanders J, Conley N, Ge X, Langan M, Ramaswamy V, Ellis L, Litzenburger U, Bolin S, ... ... Wechsler-Reya RJ, et al. Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma. Science Signaling. 11. PMID 30206138 DOI: 10.1126/Scisignal.Aau5147 |
0.806 |
|
| 2018 |
Wang Y, Li Y, Yue M, Wang J, Kumar S, Wechsler-Reya RJ, Zhang Z, Ogawa Y, Kellis M, Duester G, Zhao JC. Publisher Correction: N-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nature Neuroscience. PMID 29880878 DOI: 10.1038/S41593-018-0169-2 |
0.332 |
|
| 2018 |
Wang J, Garancher A, Ramaswamy V, Wechsler-Reya RJ. Medulloblastoma: From Molecular Subgroups to Molecular Targeted Therapies. Annual Review of Neuroscience. PMID 29641939 DOI: 10.1146/Annurev-Neuro-070815-013838 |
0.484 |
|
| 2018 |
Garancher A, Lin CY, Morabito M, Richer W, Rocques N, Larcher M, Bihannic L, Smith K, Miquel C, Leboucher S, Herath NI, Dupuy F, Varlet P, Haberler C, Walczak C, ... ... Wechsler-Reya RJ, et al. NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma. Cancer Cell. 33: 435-449.e6. PMID 29533784 DOI: 10.1016/J.Ccell.2018.02.006 |
0.451 |
|
| 2018 |
Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, ... ... Wechsler-Reya RJ, et al. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 172: 1050-1062.e14. PMID 29474906 DOI: 10.1016/J.Cell.2018.01.038 |
0.435 |
|
| 2018 |
Wang Y, Li Y, Yue M, Wang J, Kumar S, Wechsler-Reya RJ, Zhang Z, Ogawa Y, Kellis M, Duester G, Zhao JC. N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nature Neuroscience. PMID 29335608 DOI: 10.1038/S41593-017-0057-1 |
0.419 |
|
| 2018 |
Mollaoglu G, Guthrie MR, Bohm S, Bragelmann J, Chalishazar MD, Ireland AS, Huang F, Hu Z, Cardnell RJ, Sen T, Gertz J, Johnson JE, Gazdar AF, Byers LA, DeBerardinis RJ, ... Wechsler-Reya RJ, et al. Abstract IA27: MYC drives molecular and therapeutically distinct subtype of SCLC Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Aacriaslc18-Ia27 |
0.443 |
|
| 2018 |
Prabhu VV, Madhukar N, Tarapore R, Garnett M, McDermott U, Benes C, Anantharaman L, Charter N, Deacon S, VanEngelenburg A, Rucker J, Doranz B, Rusert J, Wechsler-Reya R, Elemento O, et al. EXTH-17. SELECTIVE, NON-COMPETITIVE DRD2/3 ANTAGONISM BY IMIPRIDONE ONC206 IS EFFECTIVE IN TUMORS WITH DOPAMINE RECEPTOR DYSREGULATION Neuro-Oncology. 20: vi88-vi88. DOI: 10.1093/Neuonc/Noy148.366 |
0.316 |
|
| 2018 |
Bolin S, Savov V, Borgenvik A, Garancher A, Rosén G, Rahmanto A, Hutter S, Rusert J, Garzia L, Fotaki G, Hill RM, Dubuc AM, Remke M, aner M, Ramaswamy V, ... ... Wechsler-Reya R, et al. TMOD-35. CAN RARE SOX9-POSITIVE CELLS INCITE MYC-DRIVEN MEDULLOBLASTOMA RECURRENCE? Neuro-Oncology. 20: vi276-vi276. DOI: 10.1093/Neuonc/Noy148.1147 |
0.367 |
|
| 2018 |
Brabetz S, Groebner SN, Jaeger N, Milde T, Ecker J, Selt F, Witt O, Rusert JM, Koster J, Leary SE, Li X, Wechsler-Reya RJ, Olson JM, Pfister SM, Kool M. PCLN-05. A BIOBANK OF PATIENT-DERIVED MOLECULARLY CHARACTERIZED ORTHOTOPIC PEDIATRIC BRAIN TUMOR MODELS FOR PRECLINICAL RESEARCH Neuro-Oncology. 20: i155-i155. DOI: 10.1093/Neuonc/Noy059.574 |
0.384 |
|
| 2017 |
Meehan TF, Conte N, Goldstein T, Inghirami G, Murakami MA, Brabetz S, Gu Z, Wiser JA, Dunn P, Begley DA, Krupke DM, Bertotti A, Bruna A, Brush MH, Byrne AT, ... ... Wechsler-Reya RJ, et al. PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models. Cancer Research. 77: e62-e66. PMID 29092942 DOI: 10.1158/0008-5472.Can-17-0582 |
0.38 |
|
| 2017 |
Parada LF, Dirks PB, Wechsler-Reya RJ. Brain Tumor Stem Cells Remain in Play. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2017739540. PMID 28640710 DOI: 10.1200/Jco.2017.73.9540 |
0.474 |
|
| 2017 |
Liu KW, Pajtler KW, Worst BC, Pfister SM, Wechsler-Reya RJ. Molecular mechanisms and therapeutic targets in pediatric brain tumors. Science Signaling. 10. PMID 28292958 DOI: 10.1126/Scisignal.Aaf7593 |
0.452 |
|
| 2017 |
Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, et al. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. PMID 28178237 DOI: 10.1038/Nature21356 |
0.335 |
|
| 2017 |
Brabetz S, Gröbner SN, Seker-Cin H, Selt F, Milde T, Jones DT, Wise MT, Rusert JM, Pedro K, Strand A, Witt O, Leary SE, Li X, Wechsler-Reya RJ, Olson JM, et al. Abstract 1935: Molecular characterization of orthotopic patient-derived xenograft models of pediatric brain tumors Cancer Research. 77: 1935-1935. DOI: 10.1158/1538-7445.Am2017-1935 |
0.403 |
|
| 2017 |
Bolin S, Savov V, Borgenvik A, Garancher A, Rosén G, Rahmanto AS, Hutter S, Rusert J, Fotaki G, Hill R, Dubuc A, Remke M, Čančer M, Ramaswamy V, Clifford S, ... ... Wechsler-Reya R, et al. TMOD-31. RARE SOX9+ CELLS BEHIND MYC-DRIVEN MEDULLOBLASTOMA RECURRENCE Neuro-Oncology. 19: vi260-vi261. DOI: 10.1093/Neuonc/Nox168.1068 |
0.388 |
|
| 2017 |
Brabetz S, Schmidt C, Groebner SN, Mack N, Seker-Cin H, Jones DT, Chavez L, Milde T, Witt O, Leary SE, Li X, Wechsler-Reya RJ, Olson JM, Pfister SM, Kool M. TMOD-05. MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS AND THEIR USE IN PRECLINICAL EXPERIMENTS Neuro-Oncology. 19: iv49-iv49. DOI: 10.1093/Neuonc/Nox083.204 |
0.4 |
|
| 2017 |
Ecker J, Oehme I, Selt F, Kool M, Chavez L, Hohloch J, Valinciute G, van Tilburg CM, Schnölzer M, Warnken U, Wechsler-Reya R, Pfister SM, Witt O, Milde T. MEDU-20. TARGETING OF MYC BY HDAC INHIBITION IN MYC AMPLIFIED GROUP 3 MEDULLOBLASTOMA Neuro-Oncology. 19: iv41-iv42. DOI: 10.1093/Neuonc/Nox083.170 |
0.303 |
|
| 2016 |
Mollaoglu G, Guthrie MR, Böhm S, Brägelmann J, Can I, Ballieu PM, Marx A, George J, Heinen C, Chalishazar MD, Cheng H, Ireland AS, Denning KE, Mukhopadhyay A, Vahrenkamp JM, ... ... Wechsler-Reya RJ, et al. MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition. Cancer Cell. PMID 28089889 DOI: 10.1016/J.Ccell.2016.12.005 |
0.748 |
|
| 2016 |
Pace JR, DeBerardinis AM, Sail V, Tacheva-Grigorova SK, Chan KA, Tran R, Raccuia DS, Wechsler-Reya RJ, Hadden MK. Repurposing the Clinically Efficacious Anti-Fungal Agent Itraconazole as an Anti-Cancer Chemotherapeutic. Journal of Medicinal Chemistry. PMID 27014922 DOI: 10.1021/Acs.Jmedchem.5B01718 |
0.31 |
|
| 2016 |
Li L, Grausam KB, Wang J, Lun MP, Ohli J, Lidov HG, Calicchio ML, Zeng E, Salisbury JL, Wechsler-Reya RJ, Lehtinen MK, Schüller U, Zhao H. Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. Nature Cell Biology. PMID 26999738 DOI: 10.1038/Ncb3327 |
0.448 |
|
| 2016 |
Pei Y, Liu KW, Wang J, Garancher A, Tao R, Esparza LA, Maier DL, Udaka YT, Murad N, Morrissy S, Seker-Cin H, Brabetz S, Qi L, Kogiso M, Schubert S, ... ... Wechsler-Reya RJ, et al. HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma. Cancer Cell. 29: 311-323. PMID 26977882 DOI: 10.1016/J.Ccell.2016.02.011 |
0.805 |
|
| 2016 |
Morrissy AS, Garzia L, Shih DJ, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli FM, Ramaswamy V, Lindsay PE, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, ... ... Wechsler-Reya RJ, et al. Divergent clonal selection dominates medulloblastoma at recurrence. Nature. PMID 26760213 DOI: 10.1038/Nature16478 |
0.667 |
|
| 2016 |
Rusert JM, Garancher A, Udaka YT, Brabetz S, Esparza LA, Seker-Cin H, Qi L, Kogiso M, Schubert S, Milde T, Cho Y, Li X, Olson JM, Crawford JR, Levy ML, ... ... Wechsler-Reya RJ, et al. Abstract B37: Chemi-genomic analysis of patient-derived xenografts to identify personalized therapies for medulloblastoma Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-B37 |
0.412 |
|
| 2016 |
Brabetz S, Seker-Cin H, Gröbner SN, Mack NL, Hovestadt V, Jones DTW, Milde T, Wise MT, Rusert JM, Pedro K, Bloom K, Li X, Wechsler-Reya RJ, Olson JM, Pfister SM, et al. Abstract A07: Molecular characterization of patient-derived xenograft models of pediatric brain tumors Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-A07 |
0.476 |
|
| 2016 |
Parisian A, Koga T, Wechsler-Reya R, Furnari F. PDTB-03. ROLE OF SMARCB1 IN PEDIATRIC RHABDOID TUMORS Neuro-Oncology. 18: vi150-vi150. DOI: 10.1093/Neuonc/Now212.623 |
0.416 |
|
| 2016 |
Brabetz S, Groebner SN, Seker-Cin H, Mack NL, Hovestadt V, Jones DTW, Selt F, Milde T, Wise MT, Rusert JM, Pedro K, Bloom K, Witt O, Leary SE, Li X, ... Wechsler-Reya RJ, et al. PCM-16MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS Neuro-Oncology. 18: iii142.3-iii142. DOI: 10.1093/Neuonc/Now080.16 |
0.465 |
|
| 2016 |
Ecker J, Oehme I, Selt F, Kool M, Schnölzer M, Warnken U, Brabetz S, Wechsler-Reya R, Kulozik A, Pfister S, Witt O, Milde T. Targeting the interaction of HDAC2 and MYC in Group 3 medulloblastoma Klinische Padiatrie. 228. DOI: 10.1055/S-0036-1593553 |
0.394 |
|
| 2016 |
Gutova M, Tsaturyan L, Barish ME, Aboody KS, Wechsler-Reya R. 443. Neural Stem Cell-Mediated Enzyme/Prodrug Therapy for Medulloblastoma Molecular Therapy. 24. DOI: 10.1016/S1525-0016(16)33252-X |
0.504 |
|
| 2015 |
Langenau DM, Sweet-Cordero A, Wechsler-Reya RJ, Dyer MA. Preclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer. Cancer Research. PMID 26627009 DOI: 10.1158/0008-5472.Can-15-1308 |
0.366 |
|
| 2015 |
Pham CD, Flores C, Yang C, Pinheiro EM, Yearley JH, Sayour E, Pei Y, Moore C, McLendon RE, Huang J, Sampson JH, Wechsler-Reya RJ, Mitchell DA. Differential immune microenvironments and response to immune checkpoint blockade amongst molecular subtypes of murine medulloblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26405194 DOI: 10.1158/1078-0432.Ccr-15-0713 |
0.768 |
|
| 2015 |
Staal JA, Lau LS, Zhang H, Ingram WJ, Hallahan AR, Northcott PA, Pfister SM, Wechsler-Reya RJ, Rusert JM, Taylor MD, Cho YJ, Packer RJ, Brown KJ, Rood BR. Proteomic profiling of high risk medulloblastoma reveals functional biology. Oncotarget. 6: 14584-95. PMID 25970789 DOI: 10.18632/Oncotarget.3927 |
0.442 |
|
| 2015 |
Brun SN, Markant SL, Esparza LA, Garcia G, Terry D, Huang JM, Pavlyukov MS, Li XN, Grant GA, Crawford JR, Levy ML, Conway EM, Smith LH, Nakano I, Berezov A, ... ... Wechsler-Reya RJ, et al. Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. Oncogene. 34: 3770-9. PMID 25241898 DOI: 10.1038/Onc.2014.304 |
0.514 |
|
| 2015 |
Wu X, Dubuc A, Weiss WA, Wechsler-Reya RJ, Taylor MD. Abstract A46: Transcriptome analysis on tumor and its normal cerebellar counterpart from mouse models reveals molecular mechanisms underlying evolution of SHH and Group3 medulloblastoma Brain. 75. DOI: 10.1158/1538-7445.Brain15-A46 |
0.5 |
|
| 2015 |
Liu K, Ramaswamy V, Taylor M, Wechsler-Reya R. PTPS-17LEPTOMENINGEAL METASTASIS IN MYC-DRIVEN MEDULLOBLASTOMA Neuro-Oncology. 17: v182.4-v183. DOI: 10.1093/Neuonc/Nov228.17 |
0.521 |
|
| 2015 |
Pham C, Flores C, Yang C, Sayour E, Pei Y, Moore C, McLendon R, Huang J, Sampson J, Wechsler-Reya R, Mitchell D. IMPS-25DIFFERENTIAL TUMOR MICROENVIRONMENTS AND RESPONSE TO IMMUNE CHECKPOINT BLOCKADE IN MOLECULAR SUBTYPES OF MURINE MEDULLOBLASTOMA Neuro-Oncology. 17: v118.3-v118. DOI: 10.1093/Neuonc/Nov217.24 |
0.468 |
|
| 2015 |
Liu K, Pei Y, Wechsler-Reya R. Mb-13Hdac And Pi3K Antagonists Cooperate To Inhibit Growth Of Myc-Driven Medulloblastoma Neuro-Oncology. 17. DOI: 10.1093/Neuonc/Nov061.89 |
0.502 |
|
| 2015 |
Pham C, Flores C, Pei Y, Wechsler-Reya R, Mitchell D. IM-14 * IMMUNOLOGIC TARGETING OF MEDULLOBLASTOMA SUBTYPES USING DEVELOPMENTALLY REGULATED ANTIGENS Neuro-Oncology. 17: iii17-iii18. DOI: 10.1093/Neuonc/Nov061.68 |
0.48 |
|
| 2015 |
Gutova M, Oganesyan D, Grigorova ST, Pei Y, Shahmanyan D, Li Z, Barish M, Aboody K, Wechsler-Reya R. SC-03 * NEURAL STEM CELL-MEDIATED ENZYME/PRODRUG THERAPY FOR MEDULLOBLASTOMA Neuro-Oncology. 17: iii36-iii36. DOI: 10.1093/Neuonc/Nov061.145 |
0.496 |
|
| 2015 |
Zhao H, Li L, Picotte K, Wang J, Wechsler-Reya R, Ohli J, Schuller U. PM-15 * NOTCH AND SHH SIGNALING PATHWAYS CONVERGE ON THE PRIMARY CILIUM TO PROMOTE CHOROID PLEXUS TUMOR INITIATION FROM EPITHELIAL PROGENITORS Neuro-Oncology. 17: iii34-iii34. DOI: 10.1093/Neuonc/Nov061.137 |
0.557 |
|
| 2015 |
Brabetz S, Seker-Cin H, Grobner SN, Hovestadt V, Jones DTW, Northcott PA, Milde T, Rusert JM, Pedro K, Bloom K, Li X, Wechsler-Reya RJ, Olson JM, Pfister SM, Kool M. PM-09 * ESTABLISHMENT AND MOLECULAR CHARACTERIZATION OF PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS Neuro-Oncology. 17: iii33-iii33. DOI: 10.1093/Neuonc/Nov061.131 |
0.469 |
|
| 2014 |
Becher OJ, Wechsler-Reya RJ. Cancer. For pediatric glioma, leave no histone unturned. Science (New York, N.Y.). 346: 1458-9. PMID 25525232 DOI: 10.1126/Science.Aaa3814 |
0.377 |
|
| 2014 |
Miller TE, Wang J, Sukhdeo K, Horbinski C, Tesar PJ, Wechsler-Reya RJ, Rich JN. Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development. Plos One. 9: e114433. PMID 25493560 DOI: 10.1371/Journal.Pone.0114433 |
0.461 |
|
| 2014 |
He X, Zhang L, Chen Y, Remke M, Shih D, Lu F, Wang H, Deng Y, Yu Y, Xia Y, Wu X, Ramaswamy V, Hu T, Wang F, Zhou W, ... ... Wechsler-Reya R, et al. The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. Nature Medicine. 20: 1035-42. PMID 25150496 DOI: 10.1038/Nm.3666 |
0.459 |
|
| 2014 |
Northcott PA, Lee C, Zichner T, Stütz AM, Erkek S, Kawauchi D, Shih DJ, Hovestadt V, Zapatka M, Sturm D, Jones DT, Kool M, Remke M, Cavalli FM, Zuyderduyn S, ... ... Wechsler-Reya RJ, et al. Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. Nature. 511: 428-34. PMID 25043047 DOI: 10.1038/Nature13379 |
0.335 |
|
| 2014 |
Tang Y, Gholamin S, Schubert S, Willardson MI, Lee A, Bandopadhayay P, Bergthold G, Masoud S, Nguyen B, Vue N, Balansay B, Yu F, Oh S, Woo P, Chen S, ... ... Wechsler-Reya R, et al. Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nature Medicine. 20: 732-40. PMID 24973920 DOI: 10.1038/Nm.3613 |
0.67 |
|
| 2014 |
Hovestadt V, Jones DT, Picelli S, Wang W, Kool M, Northcott PA, Sultan M, Stachurski K, Ryzhova M, Warnatz HJ, Ralser M, Brun S, Bunt J, Jäger N, Kleinheinz K, ... ... Wechsler-Reya RJ, et al. Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature. 510: 537-41. PMID 24847876 DOI: 10.1038/Nature13268 |
0.339 |
|
| 2014 |
Kool M, Jones DT, Jäger N, Northcott PA, Pugh TJ, Hovestadt V, Piro RM, Esparza LA, Markant SL, Remke M, Milde T, Bourdeaut F, Ryzhova M, Sturm D, Pfaff E, ... ... Wechsler-Reya RJ, et al. Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer Cell. 25: 393-405. PMID 24651015 DOI: 10.1016/J.Ccr.2014.02.004 |
0.347 |
|
| 2014 |
Green MJ, Myat AM, Emmenegger BA, Wechsler-Reya RJ, Wilson LJ, Wingate RJ. Independently specified Atoh1 domains define novel developmental compartments in rhombomere 1. Development (Cambridge, England). 141: 389-98. PMID 24381197 DOI: 10.1242/Dev.099119 |
0.357 |
|
| 2014 |
Bandopadhayay P, Bergthold G, Nguyen B, Schubert S, Gholamin S, Tang Y, Bolin S, Schumacher SE, Zeid R, Masoud S, Yu F, Vue N, Gibson WJ, Paolella BR, Mitra SS, ... ... Wechsler-Reya R, et al. BET bromodomain inhibition of MYC-amplified medulloblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 912-25. PMID 24297863 DOI: 10.1158/1078-0432.Ccr-13-2281 |
0.422 |
|
| 2014 |
Wang J, Wechsler-Reya RJ. The role of stem cells and progenitors in the genesis of medulloblastoma. Experimental Neurology. 260: 69-73. PMID 23178582 DOI: 10.1016/J.Expneurol.2012.11.014 |
0.547 |
|
| 2014 |
Tang Y, Schubert S, Qi J, Nguyen B, Masoud S, Vue N, Balansay B, Yu F, Atwood SX, Whitson RJ, Ponnuswami A, Chen S, Gholamin S, Pamelyn WJ, Monje-Diesseroth M, ... ... Wechsler-Reya R, et al. Abstract B6: Epigenetic regulation of Hedgehog pathway transcriptional output by BET bromodomain proteins Cancer Research. 74. DOI: 10.1158/1538-7445.Pedcan-B6 |
0.645 |
|
| 2014 |
Lee C, Northcott PA, Zichner T, Lichter P, Korbel JO, Pfister SM, Wechsler-Reya RJ. Abstract LB-203: Structural variants shuffle chromatin to activate GFI1 family oncogenes in medulloblastoma Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-203 |
0.378 |
|
| 2014 |
Lee C, Northcott PA, Zichner T, Lichter P, Korbel JO, Pfister SM, Wechsler-Reya RJ. PM-09 * REGULATION OF MEDULLOBLASTOMA FORMATION BY Gfi1 AND Gfi1B Neuro-Oncology. 16: v170-v171. DOI: 10.1093/Neuonc/Nou268.9 |
0.49 |
|
| 2014 |
Wang J, Eberhart C, Ellison D, Vandenberg S, Wechsler-Reya R. PM-22 * GENETICALLY ENGINEERED MOUSE MODELS OF CHOROID PLEXUS TUMORS Neuro-Oncology. 16: v173-v173. DOI: 10.1093/Neuonc/Nou268.22 |
0.556 |
|
| 2014 |
Pham C, Flores C, Pei Y, Wechsler-Reya R, Mitchell D. IT-25 * DEVELOPMENTALLY REGULATED ANTIGENS FOR IMMUNOLOGIC TARGETING OF MEDULLOBLASTOMA SUBTYPES Neuro-Oncology. 16: v115-v115. DOI: 10.1093/Neuonc/Nou258.23 |
0.476 |
|
| 2014 |
Northcott P, Lee C, Zichner T, Lichter P, Korbel J, Wechsler-Reya R, Pfister S. Ge-23Enhancer Hijacking Activates Gfi1 Family Oncogenes In Medulloblastoma. Neuro-Oncology. 16. DOI: 10.1093/Neuonc/Nou256.22 |
0.331 |
|
| 2014 |
Cho Y, Tang Y, Schubert S, Willardson M, Bandopadhayay P, Bergthold G, Nguyen B, Masoud S, Vue N, Balansay B, Gholamin S, Cheshier SH, Atwood SX, Whitson RJ, Lee A, ... ... Wechsler-Reya R, et al. EPIGENETIC TARGETING OF HEDGEHOG PATHWAY TRANSCRIPTIONAL OUTPUT Neuro-Oncology. 16: iii25-iii25. DOI: 10.1093/Neuonc/Nou208.9 |
0.695 |
|
| 2014 |
Wechsler-Reya RJ, Pei Y, Liu K, Wang J, Esparza LA, Maier DL, Li X, Cho Y. HIGH-THROUGHPUT DRUG SCREENING IDENTIFIES HDAC INHIBITORS AS CANDIDATE THERAPEUTICS FOR MYC-DRIVEN MEDULLOBLASTOMA Neuro-Oncology. 16: iii29-iii29. DOI: 10.1093/Neuonc/Nou208.22 |
0.428 |
|
| 2013 |
Remke M, Ramaswamy V, Peacock J, Shih DJ, Koelsche C, Northcott PA, Hill N, Cavalli FM, Kool M, Wang X, Mack SC, Barszczyk M, Morrissy AS, Wu X, Agnihotri S, ... ... Wechsler-Reya RJ, et al. TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma. Acta Neuropathologica. 126: 917-29. PMID 24174164 DOI: 10.1007/S00401-013-1198-2 |
0.342 |
|
| 2013 |
Li P, Du F, Yuelling LW, Lin T, Muradimova RE, Tricarico R, Wang J, Enikolopov G, Bellacosa A, Wechsler-Reya RJ, Yang ZJ. A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity. Nature Neuroscience. 16: 1737-44. PMID 24141309 DOI: 10.1038/Nn.3553 |
0.737 |
|
| 2013 |
Markant SL, Esparza LA, Sun J, Barton KL, McCoig LM, Grant GA, Crawford JR, Levy ML, Northcott PA, Shih D, Remke M, Taylor MD, Wechsler-Reya RJ. Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases. Cancer Research. 73: 6310-22. PMID 24067506 DOI: 10.1158/0008-5472.Can-12-4258 |
0.512 |
|
| 2013 |
Emmenegger BA, Hwang EI, Moore C, Markant SL, Brun SN, Dutton JW, Read TA, Fogarty MP, Singh AR, Durden DL, Yang C, McKeehan WL, Wechsler-Reya RJ. Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma. Oncogene. 32: 4181-8. PMID 23045271 DOI: 10.1038/Onc.2012.440 |
0.499 |
|
| 2012 |
Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T, Stütz AM, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, ... ... Wechsler-Reya RJ, et al. Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature. 488: 49-56. PMID 22832581 DOI: 10.1038/Nature11327 |
0.354 |
|
| 2012 |
Pei Y, Brun SN, Markant SL, Lento W, Gibson P, Taketo MM, Giovannini M, Gilbertson RJ, Wechsler-Reya RJ. WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum. Development (Cambridge, England). 139: 1724-33. PMID 22461560 DOI: 10.1242/Dev.050104 |
0.792 |
|
| 2012 |
Pei Y, Moore CE, Wang J, Tewari AK, Eroshkin A, Cho YJ, Witt H, Korshunov A, Read TA, Sun JL, Schmitt EM, Miller CR, Buckley AF, McLendon RE, Westbrook TF, ... ... Wechsler-Reya RJ, et al. An animal model of MYC-driven medulloblastoma. Cancer Cell. 21: 155-67. PMID 22340590 DOI: 10.1016/J.Ccr.2011.12.021 |
0.821 |
|
| 2012 |
Lau J, Schmidt C, Markant SL, Taylor MD, Wechsler-Reya RJ, Weiss WA. Matching mice to malignancy: molecular subgroups and models of medulloblastoma. Child's Nervous System : Chns : Official Journal of the International Society For Pediatric Neurosurgery. 28: 521-32. PMID 22315164 DOI: 10.1007/S00381-012-1704-1 |
0.415 |
|
| 2012 |
Read TA, Wechsler-Reya RJ. Spheres without influence: dissociating in vitro self-renewal from tumorigenic potential in glioma. Cancer Cell. 21: 1-3. PMID 22264781 DOI: 10.1016/J.Ccr.2011.12.011 |
0.436 |
|
| 2012 |
Sengupta R, Dubuc A, Ward S, Yang L, Northcott P, Woerner BM, Kroll K, Luo J, Taylor MD, Wechsler-Reya RJ, Rubin JB. CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma. Cancer Research. 72: 122-32. PMID 22052462 DOI: 10.1158/0008-5472.Can-11-1701 |
0.481 |
|
| 2012 |
Markant S, Esparza LA, Barton K, Sun J, Wechsler-Reya R. Abstract CN07-02: Targeting tumor-initiating cells in medulloblastoma Cancer Prevention Research. 5. DOI: 10.1158/1940-6207.Prev-12-Cn07-02 |
0.522 |
|
| 2012 |
Markant S, Esparza LA, Barton K, Sun J, Wechsler-Reya R. Abstract B46: Targeting tumor-propagating cells in medulloblastoma through inhibition of G2/M cell cycle regulators Clinical Cancer Research. 18. DOI: 10.1158/1078-0432.Mechres-B46 |
0.478 |
|
| 2011 |
Gibson P, Tong Y, Robinson G, Poppleton H, Thompson MC, Currle DS, Eden C, Hogg TL, Finkelstein D, Pounds S, Patay Z, Scoggins M, Pei Y, Ogg R, Lee Y, ... ... Wechsler-Reya R, et al. Abstract 3448: Subtypes of medulloblastoma have distinct developmental origins Cancer Research. 71: 3448-3448. DOI: 10.1158/1538-7445.Am2011-3448 |
0.529 |
|
| 2011 |
Markant SL, Barton K, Sun J, Wechsler-Reya R. Abstract 3443: Targeting G2/M cell cycle regulators in medulloblastoma tumor-propagating cells Cancer Research. 71: 3443-3443. DOI: 10.1158/1538-7445.Am2011-3443 |
0.481 |
|
| 2010 |
Pei Y, Wechsler-Reya RJ. A malignant oligarchy: progenitors govern the behavior of oligodendrogliomas. Cancer Cell. 18: 546-7. PMID 21156279 DOI: 10.1016/J.Ccr.2010.11.031 |
0.798 |
|
| 2010 |
Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, ... ... Wechsler-Reya R, et al. Subtypes of medulloblastoma have distinct developmental origins. Nature. 468: 1095-9. PMID 21150899 DOI: 10.1038/Nature09587 |
0.785 |
|
| 2010 |
Claus EB, Abdel-Wahab M, Burger PC, Engelhard HH, Ellison DW, Gaiano N, Gutmann DH, Heck DA, Holland EC, Jallo GI, Kruchko C, Kun LE, Maria BL, Rumboldt Z, Seminara D, ... ... Wechsler-Reya R, et al. Defining future directions in spinal cord tumor research: proceedings from the National Institutes of Health workshop. Journal of Neurosurgery. Spine. 12: 117-21. PMID 20121344 DOI: 10.3171/2009.7.Spine09137 |
0.324 |
|
| 2010 |
Yu T, Yaguchi Y, Echevarria D, Martinez S, Wechsler-Reya R, Basson MA. Sprouty genes function as negative regulators of the FGF signalling pathway during cerebellar development Developmental Biology. 344: 443-443. DOI: 10.1016/J.Ydbio.2010.05.125 |
0.314 |
|
| 2010 |
Yu T, Yaguchi Y, Echevarria D, Martinez S, Wechsler-Reya R, Basson MA. Sprouty genes function as negative regulators of the FGF signalling pathway during cerebellar development International Journal of Developmental Neuroscience. 28: 669-669. DOI: 10.1016/J.Ijdevneu.2010.07.082 |
0.314 |
|
| 2009 |
Read TA, Fogarty MP, Markant SL, McLendon RE, Wei Z, Ellison DW, Febbo PG, Wechsler-Reya RJ. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell. 15: 135-47. PMID 19185848 DOI: 10.1016/J.Ccr.2008.12.016 |
0.444 |
|
| 2009 |
Kessler JD, Hasegawa H, Brun SN, Emmenegger BA, Yang ZJ, Dutton JW, Wang F, Wechsler-Reya RJ. N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. Genes & Development. 23: 157-70. PMID 19171780 DOI: 10.1101/Gad.1759909 |
0.779 |
|
| 2008 |
Emmenegger BA, Wechsler-Reya RJ. Stem cells and the origin and propagation of brain tumors. Journal of Child Neurology. 23: 1172-8. PMID 18952583 DOI: 10.1177/0883073808321062 |
0.503 |
|
| 2008 |
Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, Bourboulas M, Schüller U, Machold R, Fishell G, Rowitch DH, Wainwright BJ, Wechsler-Reya RJ. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell. 14: 135-45. PMID 18691548 DOI: 10.1016/J.Ccr.2008.07.003 |
0.771 |
|
| 2007 |
Johnson CE, Huang YY, Parrish AB, Smith MI, Vaughn AE, Zhang Q, Wright KM, Van Dyke T, Wechsler-Reya RJ, Kornbluth S, Deshmukh M. Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues. Proceedings of the National Academy of Sciences of the United States of America. 104: 20820-5. PMID 18093951 DOI: 10.1073/Pnas.0709101105 |
0.425 |
|
| 2007 |
Fogarty MP, Emmenegger BA, Grasfeder LL, Oliver TG, Wechsler-Reya RJ. Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 2973-8. PMID 17299056 DOI: 10.1073/Pnas.0605770104 |
0.754 |
|
| 2007 |
Yang ZJ, Wechsler-Reya RJ. Hit 'em where they live: targeting the cancer stem cell niche. Cancer Cell. 11: 3-5. PMID 17222787 DOI: 10.1016/J.Ccr.2006.12.007 |
0.756 |
|
| 2006 |
Meloni AR, Fralish GB, Kelly P, Salahpour A, Chen JK, Wechsler-Reya RJ, Lefkowitz RJ, Caron MG. Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Molecular and Cellular Biology. 26: 7550-60. PMID 16908539 DOI: 10.1128/Mcb.00546-06 |
0.323 |
|
| 2006 |
Read TA, Hegedus B, Wechsler-Reya R, Gutmann DH. The neurobiology of neurooncology. Annals of Neurology. 60: 3-11. PMID 16802285 DOI: 10.1002/Ana.20912 |
0.514 |
|
| 2005 |
Fogarty MP, Kessler JD, Wechsler-Reya RJ. Morphing into cancer: the role of developmental signaling pathways in brain tumor formation. Journal of Neurobiology. 64: 458-75. PMID 16041741 DOI: 10.1002/Neu.20166 |
0.413 |
|
| 2005 |
Lee A, Kessler JD, Read TA, Kaiser C, Corbeil D, Huttner WB, Johnson JE, Wechsler-Reya RJ. Isolation of neural stem cells from the postnatal cerebellum. Nature Neuroscience. 8: 723-9. PMID 15908947 DOI: 10.1038/Nn1473 |
0.429 |
|
| 2005 |
Oliver TG, Read TA, Kessler JD, Mehmeti A, Wells JF, Huynh TT, Lin SM, Wechsler-Reya RJ. Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma. Development (Cambridge, England). 132: 2425-39. PMID 15843415 DOI: 10.1242/Dev.01793 |
0.754 |
|
| 2004 |
Oliver TG, Wechsler-Reya RJ. Getting at the root and stem of brain tumors. Neuron. 42: 885-8. PMID 15207233 DOI: 10.1016/J.Neuron.2004.06.011 |
0.752 |
|
| 2003 |
Wechsler-Reya RJ. Analysis of gene expression in the normal and malignant cerebellum. Recent Progress in Hormone Research. 58: 227-48. PMID 12795421 DOI: 10.1210/Rp.58.1.227 |
0.459 |
|
| 2003 |
Oliver TG, Grasfeder LL, Carroll AL, Kaiser C, Gillingham CL, Lin SM, Wickramasinghe R, Scott MP, Wechsler-Reya RJ. Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proceedings of the National Academy of Sciences of the United States of America. 100: 7331-6. PMID 12777630 DOI: 10.1073/Pnas.0832317100 |
0.752 |
|
| 2001 |
Wechsler-Reya RJ. Caught in the matrix: how vitronectin controls neuronal differentiation. Trends in Neurosciences. 24: 680-2. PMID 11718852 DOI: 10.1016/S0166-2236(00)02058-0 |
0.355 |
|
| 2001 |
Wechsler-Reya R, Scott MP. The developmental biology of brain tumors Annual Review of Neuroscience. 24: 385-428. PMID 11283316 DOI: 10.1146/Annurev.Neuro.24.1.385 |
0.655 |
|
| 2000 |
Zurawel RH, Allen C, Wechsler-Reya R, Scott MP, Raffel C. Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice Genes Chromosomes and Cancer. 28: 77-81. PMID 10738305 DOI: 10.1002/(Sici)1098-2264(200005)28:1<77::Aid-Gcc9>3.0.Co;2-Y |
0.625 |
|
| 2000 |
Ge K, Duhadaway J, Sakamuro D, Wechsler-Reya R, Reynolds C, Prendergast GC. Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity International Journal of Cancer. 85: 376-383. PMID 10652430 DOI: 10.1002/(Sici)1097-0215(20000201)85:3<376::Aid-Ijc14>3.0.Co;2-1 |
0.79 |
|
| 1999 |
Wechsler-Reya RJ, Scott MP. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron. 22: 103-14. PMID 10027293 DOI: 10.1016/S0896-6273(00)80682-0 |
0.586 |
|
| 1998 |
Wechsler-Reya RJ, Elliott KJ, Prendergast GC. A role for the putative tumor suppressor Bin1 in muscle cell differentiation. Molecular and Cellular Biology. 18: 566-75. PMID 9418903 DOI: 10.1128/Mcb.18.1.566 |
0.616 |
|
| 1997 |
Wechsler-Reya R, Sakamuro D, Zhang J, Duhadaway J, Prendergast GC. Structural analysis of the human BIN1 gene: Evidence for tissue-specific transcriptional regulation and alternate RNA splicing Journal of Biological Chemistry. 272: 31453-31458. PMID 9395479 DOI: 10.1074/Jbc.272.50.31453 |
0.754 |
|
| 1997 |
Wechsler-Reya R, Elliott K, Herlyn M, Prendergast GC. The putative tumor suppressor BIN1 is a short-lived nuclear phosphoprotein, the localization of which is altered in malignant cells. Cancer Research. 57: 3258-63. PMID 9242458 |
0.32 |
|
| 1996 |
Sakamuro D, Elliott KJ, Wechsler-Reya R, Prendergast GC. BIN1 is a novel MYC-interacting protein with features of a tumour suppressor Nature Genetics. 14: 69-77. PMID 8782822 DOI: 10.1038/Ng0996-69 |
0.765 |
|
| 1996 |
Negorev D, Riethman H, Wechsler-Reya R, Sakamuro D, Prendergast GC, Simon D. The Bin1 gene localizes to human chromosome 2q14 by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization Genomics. 33: 329-331. PMID 8725406 DOI: 10.1006/Geno.1996.0205 |
0.717 |
|
| 1996 |
Prendergast GC, Davide JP, Lebowitz PF, Wechsler-Reya R, Kohl NE. Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors Cancer Research. 56: 2626-2632. PMID 8653708 |
0.731 |
|
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