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Vinay K. Pathak - Publications

Affiliations: 
West Virginia University, Morgantown, WV, United States 
Area:
Molecular Biology, Genetics, Microbiology Biology
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131 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Delviks-Frankenberry KA, Ojha CR, Hermann KJ, Hu WS, Torbett BE, Pathak VK. Potent dual block to HIV-1 infection using lentiviral vectors expressing fusion inhibitor peptide mC46- and Vif-resistant APOBEC3G. Molecular Therapy. Nucleic Acids. 33: 794-809. PMID 37662965 DOI: 10.1016/j.omtn.2023.08.007  0.343
2023 Nikolaitchik OA, Islam S, Kitzrow JP, Duchon A, Cheng Z, Liu Y, Rawson JMO, Shao W, Nikolaitchik M, Kearney MF, Maldarelli F, Musier-Forsyth K, Pathak VK, Hu WS. HIV-1 usurps transcription start site heterogeneity of host RNA polymerase II to maximize replication fitness. Proceedings of the National Academy of Sciences of the United States of America. 120: e2305103120. PMID 37252967 DOI: 10.1073/pnas.2305103120  0.393
2022 Rawson JMO, Nikolaitchik OA, Yoo JA, Somoulay X, Brown MA, Mbuntcha Bogni FS, Pathak VK, Soheilian F, Slack RL, Sarafianos SG, Hu WS. Adaptation of HIV-1/HIV-2 Chimeras with Defects in Genome Packaging and Viral Replication. Mbio. e0222022. PMID 36036631 DOI: 10.1128/mbio.02220-22  0.432
2022 Rawson JMO, Nikolaitchik OA, Shakya S, Keele BF, Pathak VK, Hu WS. Transcription Start Site Heterogeneity and Preferential Packaging of Specific Full-Length RNA Species Are Conserved Features of Primate Lentiviruses. Microbiology Spectrum. e0105322. PMID 35736240 DOI: 10.1128/spectrum.01053-22  0.396
2022 Burdick RC, Deleage C, Duchon A, Estes JD, Hu WS, Pathak VK. Intranuclear Positions of HIV-1 Proviruses Are Dynamic and Do Not Correlate with Transcriptional Activity. Mbio. e0325621. PMID 35012348 DOI: 10.1128/mbio.03256-21  0.344
2021 Nikolaitchik OA, Liu S, Kitzrow JP, Liu Y, Rawson JMO, Shakya S, Cheng Z, Pathak VK, Hu WS, Musier-Forsyth K. Selective packaging of HIV-1 RNA genome is guided by the stability of 5' untranslated region polyA stem. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34873042 DOI: 10.1073/pnas.2114494118  0.31
2021 Duchon A, Santos S, Chen J, Brown M, Nikolaitchik OA, Tai S, Chao JA, Freed EO, Pathak VK, Hu WS. Plasma Membrane Anchoring and Gag:Gag Multimerization on Viral RNA Are Critical Properties of HIV-1 Gag Required To Mediate Efficient Genome Packaging. Mbio. e0325421. PMID 34872357 DOI: 10.1128/mbio.03254-21  0.344
2020 Umunnakwe CN, Duchon A, Nikolaitchik OA, Abdul Rahman S, Liu Y, Chen J, Tai S, Pathak VK, Hu WS. Specific Guanosines in the HIV-2 Leader RNA Are Essential for Efficient Viral GenomePackaging. Journal of Molecular Biology. PMID 33221337 DOI: 10.1016/j.jmb.2020.11.017  0.435
2020 Chen J, Umunnakwe C, Sun DQ, Nikolaitchik OA, Pathak VK, Berkhout B, Das AT, Hu WS. Impact of Nuclear Export Pathway on Cytoplasmic HIV-1 RNA Transport Mechanism and Distribution. Mbio. 11. PMID 33172997 DOI: 10.1128/mBio.01578-20  0.343
2020 Maiti A, Myint W, Delviks-Frankenberry KA, Hou S, Kanai T, Balachandran V, Sierra Rodriguez C, Tripathi R, Kurt Yilmaz N, Pathak VK, Schiffer CA, Matsuo H. Crystal structure of a soluble APOBEC3G variant suggests ssDNA to bind in a channel that extends between the two domains. Journal of Molecular Biology. PMID 33098858 DOI: 10.1016/j.jmb.2020.10.020  0.301
2020 Nikolaitchik OA, Somoulay X, Rawson JMO, Yoo JA, Pathak VK, Hu WS. Unpaired Guanosines in the 5' Untranslated Region of HIV-1 RNA Act Synergistically to Mediate Genome Packaging. Journal of Virology. PMID 32796062 DOI: 10.1128/Jvi.00439-20  0.482
2020 Liu D, Ndongwe TP, Puray-Chavez M, Casey MC, Izumi T, Pathak VK, Tedbury PR, Sarafianos SG. Effect of P-body component Mov10 on HCV virus production and infectivity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32496609 DOI: 10.1096/Fj.201800641R  0.311
2020 Delviks-Frankenberry KA, Desimmie BA, Pathak VK. Structural Insights into APOBEC3-Mediated Lentiviral Restriction. Viruses. 12. PMID 32471198 DOI: 10.3390/V12060587  0.38
2020 Chen J, Liu Y, Wu B, Nikolaitchik OA, Mohan PR, Chen J, Pathak VK, Hu WS. Visualizing the translation and packaging of HIV-1 full-length RNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 32132202 DOI: 10.1073/Pnas.1917590117  0.472
2020 Burdick RC, Li C, Munshi M, Rawson JMO, Nagashima K, Hu WS, Pathak VK. HIV-1 uncoats in the nucleus near sites of integration. Proceedings of the National Academy of Sciences of the United States of America. PMID 32094182 DOI: 10.1073/Pnas.1920631117  0.485
2019 Hu Y, Desimmie BA, Nguyen HC, Ziegler SJ, Cheng TC, Chen J, Wang J, Wang H, Zhang K, Pathak VK, Xiong Y. Structural basis of antagonism of human APOBEC3F by HIV-1 Vif. Nature Structural & Molecular Biology. PMID 31792451 DOI: 10.1038/S41594-019-0343-6  0.447
2019 Delviks-Frankenberry KA, Ackerman D, Timberlake ND, Hamscher M, Nikolaitchik OA, Hu WS, Torbett BE, Pathak VK. Development of Lentiviral Vectors for HIV-1 Gene Therapy with Vif-Resistant APOBEC3G. Molecular Therapy. Nucleic Acids. 18: 1023-1038. PMID 31778955 DOI: 10.1016/J.Omtn.2019.10.024  0.455
2019 Fernandez MV, Delviks-Frankenberry KA, Scheiblin DA, Happel C, Pathak VK, Freed EO. Authentication analysis of MT-4 cells distributed by the NIH AIDS Reagent Program. Journal of Virology. PMID 31554688 DOI: 10.1128/Jvi.01390-19  0.411
2018 Rawson JMO, Nikolaitchik OA, Keele BF, Pathak VK, Hu WS. Recombination is required for efficient HIV-1 replication and the maintenance of viral genome integrity. Nucleic Acids Research. PMID 30307534 DOI: 10.1093/nar/gky910  0.426
2018 Maiti A, Myint W, Kanai T, Delviks-Frankenberry K, Sierra Rodriguez C, Pathak VK, Schiffer CA, Matsuo H. Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA. Nature Communications. 9: 2460. PMID 29941968 DOI: 10.1038/S41467-018-04872-8  0.452
2018 Ziegler SJ, Liu C, Landau M, Buzovetsky O, Desimmie BA, Zhao Q, Sasaki T, Burdick RC, Pathak VK, Anderson KS, Xiong Y. Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies. Plos One. 13: e0195048. PMID 29596531 DOI: 10.1371/Journal.Pone.0195048  0.397
2017 Liu Y, Chen J, Nikolaitchik OA, Desimmie BA, Busan S, Pathak VK, Weeks KM, Hu WS. The roles of five conserved lentiviral RNA structures in HIV-1 replication. Virology. 514: 1-8. PMID 29128752 DOI: 10.1016/J.Virol.2017.10.020  0.525
2017 Burdick RC, Delviks-Frankenberry KA, Chen J, Janaka SK, Sastri J, Hu WS, Pathak VK. Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes. Plos Pathogens. 13: e1006570. PMID 28827840 DOI: 10.1371/Journal.Ppat.1006570  0.417
2017 Liu Y, Nikolaitchik OA, Rahman SA, Chen J, Pathak VK, Hu WS. HIV-1 Sequence Necessary and Sufficient to Package Non-viral RNAs into HIV-1 Particles. Journal of Molecular Biology. PMID 28673553 DOI: 10.1016/J.Jmb.2017.06.018  0.467
2017 Dilley KA, Nikolaitchik OA, Galli A, Burdick RC, Levine L, Li K, Rein A, Pathak VK, Hu WS. Interactions Between HIV-1 Gag and Viral RNA Genome Enhance Virion Assembly. Journal of Virology. PMID 28539452 DOI: 10.1128/Jvi.02319-16  0.496
2017 Desimmie BA, Smith JL, Matsuo H, Hu WS, Pathak VK. Identification of a tripartite interaction between the N-terminus of HIV-1 Vif and CBFβ that is critical for Vif function. Retrovirology. 14: 19. PMID 28302150 DOI: 10.1186/S12977-017-0346-5  0.389
2016 Desimmie BA, Burdick RC, Izumi T, Doi H, Shao W, Alvord WG, Sato K, Koyanagi Y, Jones S, Wilson E, Hill S, Maldarelli F, Hu WS, Pathak VK. APOBEC3 proteins can copackage and comutate HIV-1 genomes. Nucleic Acids Research. PMID 27439715 DOI: 10.1093/Nar/Gkw653  0.424
2016 Delviks-Frankenberry KA, Nikolaitchik OA, Burdick RC, Gorelick RJ, Keele BF, Hu WS, Pathak VK. Minimal Contribution of APOBEC3-Induced G-to-A Hypermutation to HIV-1 Recombination and Genetic Variation. Plos Pathogens. 12: e1005646. PMID 27186986 DOI: 10.1371/Journal.Ppat.1005646  0.484
2015 Chen J, Rahman SA, Nikolaitchik OA, Grunwald D, Sardo L, Burdick RC, Plisov S, Liang E, Tai S, Pathak VK, Hu WS. HIV-1 RNA genome dimerizes on the plasma membrane in the presence of Gag protein. Proceedings of the National Academy of Sciences of the United States of America. PMID 26712001 DOI: 10.1073/Pnas.1518572113  0.464
2015 Sardo L, Hatch SC, Chen J, Nikolaitchik O, Burdick RC, Chen D, Westlake CJ, Lockett S, Pathak VK, Hu WS. Dynamics of HIV-1 RNA Near the Plasma Membrane during Virus Assembly. Journal of Virology. 89: 10832-40. PMID 26292321 DOI: 10.1128/Jvi.01146-15  0.437
2015 Nikolaitchik O, Keele B, Gorelick R, Alvord WG, Mazurov D, Pathak VK, Hu WS. High recombination potential of subtype A HIV-1. Virology. 484: 334-40. PMID 26164392 DOI: 10.1016/J.Virol.2015.06.025  0.453
2015 Chikaev AN, Bakulina AY, Burdick RC, Karpenko LI, Pathak VK, Ilyichev AA. Selection of peptide mimics of HIV-1 epitope recognized by neutralizing antibody VRC01. Plos One. 10: e0120847. PMID 25785734 DOI: 10.1371/Journal.Pone.0120847  0.326
2014 Chen J, Grunwald D, Sardo L, Galli A, Plisov S, Nikolaitchik OA, Chen D, Lockett S, Larson DR, Pathak VK, Hu WS. Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein. Proceedings of the National Academy of Sciences of the United States of America. 111: E5205-13. PMID 25404326 DOI: 10.1073/Pnas.1413169111  0.446
2014 Sato K, Takeuchi JS, Misawa N, Izumi T, Kobayashi T, Kimura Y, Iwami S, Takaori-Kondo A, Hu WS, Aihara K, Ito M, An DS, Pathak VK, Koyanagi Y. APOBEC3D and APOBEC3F potently promote HIV-1 diversification and evolution in humanized mouse model. Plos Pathogens. 10: e1004453. PMID 25330146 DOI: 10.1371/Journal.Ppat.1004453  0.514
2014 Smith JL, Izumi T, Borbet TC, Hagedorn AN, Pathak VK. HIV-1 and HIV-2 Vif interact with human APOBEC3 proteins using completely different determinants. Journal of Virology. 88: 9893-908. PMID 24942576 DOI: 10.1128/Jvi.01318-14  0.441
2014 Desimmie BA, Delviks-Frankenberrry KA, Burdick RC, Qi D, Izumi T, Pathak VK. Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all. Journal of Molecular Biology. 426: 1220-45. PMID 24189052 DOI: 10.1016/J.Jmb.2013.10.033  0.499
2013 Burdick RC, Hu WS, Pathak VK. Nuclear import of APOBEC3F-labeled HIV-1 preintegration complexes. Proceedings of the National Academy of Sciences of the United States of America. 110: E4780-9. PMID 24248339 DOI: 10.1073/Pnas.1315996110  0.463
2013 Hatch SC, Sardo L, Chen J, Burdick R, Gorelick R, Fivash MJ, Pathak VK, Hu WS. Gag-dependent enrichment of HIV-1 RNA near the uropod membrane of polarized T cells. Journal of Virology. 87: 11912-5. PMID 23966405 DOI: 10.1128/Jvi.01680-13  0.453
2013 Delviks-Frankenberry K, Paprotka T, Cingöz O, Wildt S, Hu WS, Coffin JM, Pathak VK. Generation of multiple replication-competent retroviruses through recombination between PreXMRV-1 and PreXMRV-2. Journal of Virology. 87: 11525-37. PMID 23966380 DOI: 10.1128/Jvi.01787-13  0.467
2013 Izumi T, Burdick R, Shigemi M, Plisov S, Hu WS, Pathak VK. Mov10 and APOBEC3G localization to processing bodies is not required for virion incorporation and antiviral activity. Journal of Virology. 87: 11047-62. PMID 23926332 DOI: 10.1128/Jvi.02070-13  0.386
2013 Nikolaitchik OA, Dilley KA, Fu W, Gorelick RJ, Tai SH, Soheilian F, Ptak RG, Nagashima K, Pathak VK, Hu WS. Dimeric RNA recognition regulates HIV-1 genome packaging. Plos Pathogens. 9: e1003249. PMID 23555259 DOI: 10.1371/Journal.Ppat.1003249  0.441
2013 Murgai M, Thomas J, Cherepanova O, Delviks-Frankenberry K, Deeble P, Pathak VK, Rekosh D, Owens G. Xenotropic MLV envelope proteins induce tumor cells to secrete factors that promote the formation of immature blood vessels. Retrovirology. 10: 34. PMID 23537062 DOI: 10.1186/1742-4690-10-34  0.335
2013 Chaipan C, Smith JL, Hu WS, Pathak VK. APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophages. Journal of Virology. 87: 444-53. PMID 23097438 DOI: 10.1128/Jvi.00676-12  0.419
2013 Delviks-Frankenberry KA, Lengruber RB, Santos AF, Silveira JM, Soares MA, Kearney MF, Maldarelli F, Pathak VK. Connection subdomain mutations in HIV-1 subtype-C treatment-experienced patients enhance NRTI and NNRTI drug resistance. Virology. 435: 433-41. PMID 23068886 DOI: 10.1016/J.Virol.2012.09.021  0.396
2012 Delviks-Frankenberry K, Cingöz O, Coffin JM, Pathak VK. Recombinant origin, contamination, and de-discovery of XMRV. Current Opinion in Virology. 2: 499-507. PMID 22818188 DOI: 10.1016/J.Coviro.2012.06.009  0.365
2012 Del Prete GQ, Kearney MF, Spindler J, Wiegand A, Chertova E, Roser JD, Estes JD, Hao XP, Trubey CM, Lara A, Lee K, Chaipan C, Bess JW, Nagashima K, Keele BF, ... ... Pathak VK, et al. Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques. Journal of Virology. 86: 3152-66. PMID 22238316 DOI: 10.1128/Jvi.06886-11  0.434
2012 Cingöz O, Paprotka T, Delviks-Frankenberry KA, Wildt S, Hu WS, Pathak VK, Coffin JM. Characterization, mapping, and distribution of the two XMRV parental proviruses. Journal of Virology. 86: 328-38. PMID 22031947 DOI: 10.1186/1742-4690-8-S2-P10  0.303
2012 Ndongwe TP, Adedeji AO, Michailidis E, Ong YT, Hachiya A, Marchand B, Ryan EM, Rai DK, Kirby KA, Whatley AS, Burke DH, Johnson M, Ding S, Zheng YM, Liu SL, ... ... Pathak VK, et al. Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase. Nucleic Acids Research. 40: 345-59. PMID 21908397 DOI: 10.1093/Nar/Gkr694  0.52
2011 Delviks-Frankenberry KA, Chaipan C, Bagni R, Wyvill K, Yarchoan R, Pathak VK. Lack of Detection of Xenotropic Murine Leukemia Virus-Related Virus in HIV-1 Lymphoma Patients. Advances in Virology. 2011: 797820. PMID 22312354 DOI: 10.1155/2011/797820  0.432
2011 Kearney MF, Lee K, Bagni RK, Wiegand A, Spindler J, Maldarelli F, Pinto PA, Linehan WM, Vocke CD, Delviks-Frankenberry KA, Devere White RW, Del Prete GQ, Mellors JW, Lifson JD, Kewalramani VN, ... Pathak VK, et al. Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples. Advances in Virology. 2011: 272193. PMID 22312339 DOI: 10.1155/2011/272193  0.309
2011 Delviks-Frankenberry K, Galli A, Nikolaitchik O, Mens H, Pathak VK, Hu WS. Mechanisms and factors that influence high frequency retroviral recombination. Viruses. 3: 1650-80. PMID 21994801 DOI: 10.3390/V3091650  0.481
2011 Pak V, Heidecker G, Pathak VK, Derse D. The role of amino-terminal sequences in cellular localization and antiviral activity of APOBEC3B. Journal of Virology. 85: 8538-47. PMID 21715505 DOI: 10.1128/Jvi.02645-10  0.448
2011 Paprotka T, Delviks-Frankenberry KA, Cingöz O, Martinez A, Kung HJ, Tepper CG, Hu WS, Fivash MJ, Coffin JM, Pathak VK. Recombinant origin of the retrovirus XMRV. Science (New York, N.Y.). 333: 97-101. PMID 21628392 DOI: 10.1126/Science.1205292  0.322
2011 Ni N, Nikolaitchik OA, Dilley KA, Chen J, Galli A, Fu W, Prasad VV, Ptak RG, Pathak VK, Hu WS. Mechanisms of human immunodeficiency virus type 2 RNA packaging: efficient trans packaging and selection of RNA copackaging partners. Journal of Virology. 85: 7603-12. PMID 21613401 DOI: 10.1128/Jvi.00562-11  0.499
2011 Lengruber RB, Delviks-Frankenberry KA, Nikolenko GN, Baumann J, Santos AF, Pathak VK, Soares MA. Phenotypic characterization of drug resistance-associated mutations in HIV-1 RT connection and RNase H domains and their correlation with thymidine analogue mutations. The Journal of Antimicrobial Chemotherapy. 66: 702-8. PMID 21393163 DOI: 10.1093/Jac/Dkr005  0.408
2011 Chaipan C, Dilley KA, Paprotka T, Delviks-Frankenberry KA, Venkatachari NJ, Hu WS, Pathak VK. Severe restriction of xenotropic murine leukemia virus-related virus replication and spread in cultured human peripheral blood mononuclear cells. Journal of Virology. 85: 4888-97. PMID 21325415 DOI: 10.1128/Jvi.00046-11  0.413
2011 Nikolaitchik OA, Galli A, Moore MD, Pathak VK, Hu WS. Multiple barriers to recombination between divergent HIV-1 variants revealed by a dual-marker recombination assay. Journal of Molecular Biology. 407: 521-31. PMID 21295586 DOI: 10.1016/J.Jmb.2011.01.052  0.467
2010 Delviks-Frankenberry KA, Nikolenko GN, Pathak VK. The "Connection" Between HIV Drug Resistance and RNase H. Viruses. 2: 1476-1503. PMID 21088701 DOI: 10.3390/V2071476  0.41
2010 Smith JL, Pathak VK. Identification of specific determinants of human APOBEC3F, APOBEC3C, and APOBEC3DE and African green monkey APOBEC3F that interact with HIV-1 Vif. Journal of Virology. 84: 12599-608. PMID 20943965 DOI: 10.1128/Jvi.01437-10  0.487
2010 Burdick R, Smith JL, Chaipan C, Friew Y, Chen J, Venkatachari NJ, Delviks-Frankenberry KA, Hu WS, Pathak VK. P body-associated protein Mov10 inhibits HIV-1 replication at multiple stages. Journal of Virology. 84: 10241-53. PMID 20668078 DOI: 10.1128/Jvi.00585-10  0.496
2010 Galli A, Kearney M, Nikolaitchik OA, Yu S, Chin MP, Maldarelli F, Coffin JM, Pathak VK, Hu WS. Patterns of Human Immunodeficiency Virus type 1 recombination ex vivo provide evidence for coadaptation of distant sites, resulting in purifying selection for intersubtype recombinants during replication. Journal of Virology. 84: 7651-61. PMID 20504919 DOI: 10.1128/Jvi.00276-10  0.375
2010 Paprotka T, Venkatachari NJ, Chaipan C, Burdick R, Delviks-Frankenberry KA, Hu WS, Pathak VK. Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs. Journal of Virology. 84: 5719-29. PMID 20335265 DOI: 10.1128/Jvi.00134-10  0.424
2010 Nikolenko GN, Delviks-Frankenberry KA, Pathak VK. A novel molecular mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors. Journal of Virology. 84: 5238-49. PMID 20219933 DOI: 10.1128/Jvi.01545-09  0.385
2010 Mbisa JL, Bu W, Pathak VK. APOBEC3F and APOBEC3G inhibit HIV-1 DNA integration by different mechanisms. Journal of Virology. 84: 5250-9. PMID 20219927 DOI: 10.1128/Jvi.02358-09  0.481
2009 Smith JL, Bu W, Burdick RC, Pathak VK. Multiple ways of targeting APOBEC3-virion infectivity factor interactions for anti-HIV-1 drug development. Trends in Pharmacological Sciences. 30: 638-46. PMID 19837465 DOI: 10.1016/J.Tips.2009.09.006  0.397
2009 Chen J, Nikolaitchik O, Singh J, Wright A, Bencsics CE, Coffin JM, Ni N, Lockett S, Pathak VK, Hu WS. High efficiency of HIV-1 genomic RNA packaging and heterozygote formation revealed by single virion analysis. Proceedings of the National Academy of Sciences of the United States of America. 106: 13535-40. PMID 19628694 DOI: 10.1073/Pnas.0906822106  0.455
2009 Delviks-Frankenberry KA, Nikolenko GN, Maldarelli F, Hase S, Takebe Y, Pathak VK. Subtype-specific differences in the human immunodeficiency virus type 1 reverse transcriptase connection subdomain of CRF01_AE are associated with higher levels of resistance to 3'-azido-3'-deoxythymidine. Journal of Virology. 83: 8502-13. PMID 19553318 DOI: 10.1128/Jvi.00859-09  0.442
2009 Friew YN, Boyko V, Hu WS, Pathak VK. Intracellular interactions between APOBEC3G, RNA, and HIV-1 Gag: APOBEC3G multimerization is dependent on its association with RNA. Retrovirology. 6: 56. PMID 19497112 DOI: 10.1186/1742-4690-6-56  0.444
2009 Jern P, Russell RA, Pathak VK, Coffin JM. Likely role of APOBEC3G-mediated G-to-A mutations in HIV-1 evolution and drug resistance. Plos Pathogens. 5: e1000367. PMID 19343218 DOI: 10.1371/Journal.Ppat.1000367  0.451
2009 Russell RA, Moore MD, Hu WS, Pathak VK. APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA. Retrovirology. 6: 16. PMID 19216784 DOI: 10.1186/1742-4690-6-16  0.52
2009 Perkovic M, Schmidt S, Marino D, Russell RA, Stauch B, Hofmann H, Kopietz F, Kloke BP, Zielonka J, Ströver H, Hermle J, Lindemann D, Pathak VK, Schneider G, Löchelt M, et al. Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet. The Journal of Biological Chemistry. 284: 5819-26. PMID 19074429 DOI: 10.1074/Jbc.M808853200  0.379
2009 Russell RA, Smith J, Barr R, Bhattacharyya D, Pathak VK. Distinct domains within APOBEC3G and APOBEC3F interact with separate regions of human immunodeficiency virus type 1 Vif. Journal of Virology. 83: 1992-2003. PMID 19036809 DOI: 10.1128/Jvi.01621-08  0.395
2009 Mbisa JL, Delviks-Frankenberry KA, Thomas JA, Gorelick RJ, Pathak VK. Real-time PCR analysis of HIV-1 replication post-entry events. Methods in Molecular Biology (Clifton, N.J.). 485: 55-72. PMID 19020818 DOI: 10.1007/978-1-59745-170-3_5  0.507
2008 Delviks-Frankenberry KA, Nikolenko GN, Boyer PL, Hughes SH, Coffin JM, Jere A, Pathak VK. HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision. Proceedings of the National Academy of Sciences of the United States of America. 105: 10943-8. PMID 18667707 DOI: 10.1073/Pnas.0804660105  0.474
2008 Moore MD, Fu W, Soheilian F, Nagashima K, Ptak RG, Pathak VK, Hu WS. Suboptimal inhibition of protease activity in human immunodeficiency virus type 1: effects on virion morphogenesis and RNA maturation. Virology. 379: 152-60. PMID 18657842 DOI: 10.1016/J.Virol.2008.06.030  0.482
2008 Chen J, Pathak VK, Peng W, Hu WS. Capsid proteins from human immunodeficiency virus type 1 and simian immunodeficiency virus SIVmac can coassemble into mature cores of infectious viruses. Journal of Virology. 82: 8253-61. PMID 18579598 DOI: 10.1128/Jvi.02663-07  0.44
2008 Nikolaitchik OA, Gorelick RJ, Leavitt MG, Pathak VK, Hu WS. Functional complementation of nucleocapsid and late domain PTAP mutants of human immunodeficiency virus type 1 during replication. Virology. 375: 539-49. PMID 18353416 DOI: 10.1016/J.Virol.2008.02.026  0.526
2008 Santos AF, Lengruber RB, Soares EA, Jere A, Sprinz E, Martinez AM, Silveira J, Sion FS, Pathak VK, Soares MA. Conservation patterns of HIV-1 RT connection and RNase H domains: identification of new mutations in NRTI-treated patients. Plos One. 3: e1781. PMID 18335052 DOI: 10.1371/Journal.Pone.0001781  0.411
2007 Russell RA, Pathak VK. Identification of two distinct human immunodeficiency virus type 1 Vif determinants critical for interactions with human APOBEC3G and APOBEC3F. Journal of Virology. 81: 8201-10. PMID 17522216 DOI: 10.1128/Jvi.00395-07  0.439
2007 Brehm JH, Koontz D, Meteer JD, Pathak V, Sluis-Cremer N, Mellors JW. Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine. Journal of Virology. 81: 7852-9. PMID 17507476 DOI: 10.1128/Jvi.02203-06  0.436
2007 Delviks-Frankenberry KA, Nikolenko GN, Barr R, Pathak VK. Mutations in human immunodeficiency virus type 1 RNase H primer grip enhance 3'-azido-3'-deoxythymidine resistance. Journal of Virology. 81: 6837-45. PMID 17428874 DOI: 10.1128/Jvi.02820-06  0.428
2007 Mbisa JL, Barr R, Thomas JA, Vandegraaff N, Dorweiler IJ, Svarovskaia ES, Brown WL, Mansky LM, Gorelick RJ, Harris RS, Engelman A, Pathak VK. Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration. Journal of Virology. 81: 7099-110. PMID 17428871 DOI: 10.1128/Jvi.00272-07  0.494
2007 Thomas DC, Voronin YA, Nikolenko GN, Chen J, Hu WS, Pathak VK. Determination of the ex vivo rates of human immunodeficiency virus type 1 reverse transcription by using novel strand-specific amplification analysis. Journal of Virology. 81: 4798-807. PMID 17314159 DOI: 10.1128/Jvi.02471-06  0.772
2007 Nikolenko GN, Delviks-Frankenberry KA, Palmer S, Maldarelli F, Fivash MJ, Coffin JM, Pathak VK. Mutations in the connection domain of HIV-1 reverse transcriptase increase 3'-azido-3'-deoxythymidine resistance. Proceedings of the National Academy of Sciences of the United States of America. 104: 317-22. PMID 17179211 DOI: 10.1073/Pnas.0609642104  0.428
2007 Xu H, Chertova E, Chen J, Ott DE, Roser JD, Hu WS, Pathak VK. Stoichiometry of the antiviral protein APOBEC3G in HIV-1 virions. Virology. 360: 247-56. PMID 17126871 DOI: 10.1016/J.Virol.2006.10.036  0.451
2006 Boyko V, Leavitt M, Gorelick R, Fu W, Nikolaitchik O, Pathak VK, Nagashima K, Hu WS. Coassembly and complementation of Gag proteins from HIV-1 and HIV-2, two distinct human pathogens. Molecular Cell. 23: 281-7. PMID 16857594 DOI: 10.1016/J.Molcel.2006.05.028  0.442
2006 Voronin YA, Sidorov IA, Pathak VK. A probability model predicting initiation efficiency of retroviral vectors with two primer-binding sites. Journal of Theoretical Biology. 242: 347-55. PMID 16631208 DOI: 10.1016/J.Jtbi.2006.03.003  0.729
2006 Krajewski K, Zhang Y, Parrish D, Deschamps J, Roller PP, Pathak VK. New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene scaffold: synthesis, resolution, and inhibitory activity. Bioorganic & Medicinal Chemistry Letters. 16: 3034-8. PMID 16527484 DOI: 10.1016/J.Bmcl.2006.02.049  0.378
2006 Fu W, Dang Q, Nagashima K, Freed EO, Pathak VK, Hu WS. Effects of Gag mutation and processing on retroviral dimeric RNA maturation. Journal of Virology. 80: 1242-9. PMID 16415001 DOI: 10.1128/Jvi.80.3.1242-1249.2006  0.496
2005 Chen J, Dang Q, Unutmaz D, Pathak VK, Maldarelli F, Powell D, Hu WS. Mechanisms of nonrandom human immunodeficiency virus type 1 infection and double infection: preference in virus entry is important but is not the sole factor. Journal of Virology. 79: 4140-9. PMID 15767415 DOI: 10.1128/Jvi.79.7.4140-4149.2005  0.445
2005 Nikolenko GN, Palmer S, Maldarelli F, Mellors JW, Coffin JM, Pathak VK. Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excision. Proceedings of the National Academy of Sciences of the United States of America. 102: 2093-8. PMID 15684061 DOI: 10.1073/Pnas.0409823102  0.515
2005 Williams KL, Zhang Y, Shkriabai N, Karki RG, Nicklaus MC, Kotrikadze N, Hess S, Le Grice SF, Craigie R, Pathak VK, Kvaratskhelia M. Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor. The Journal of Biological Chemistry. 280: 7949-55. PMID 15615720 DOI: 10.1074/Jbc.M413579200  0.412
2005 Mbisa JL, Nikolenko GN, Pathak VK. Mutations in the RNase H primer grip domain of murine leukemia virus reverse transcriptase decrease efficiency and accuracy of plus-strand DNA transfer. Journal of Virology. 79: 419-27. PMID 15596835 DOI: 10.1128/Jvi.79.1.419-427.2005  0.508
2004 Nikolenko GN, Svarovskaia ES, Delviks KA, Pathak VK. Antiretroviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase increase template-switching frequency. Journal of Virology. 78: 8761-70. PMID 15280484 DOI: 10.1128/Jvi.78.16.8761-8770.2004  0.531
2004 Svarovskaia ES, Xu H, Mbisa JL, Barr R, Gorelick RJ, Ono A, Freed EO, Hu WS, Pathak VK. Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs. The Journal of Biological Chemistry. 279: 35822-8. PMID 15210704 DOI: 10.1074/Jbc.M405761200  0.532
2004 Voronin YA, Pathak VK. Frequent dual initiation in human immunodeficiency virus-based vectors containing two primer-binding sites: a quantitative in vivo assay for function of initiation complexes. Journal of Virology. 78: 5402-13. PMID 15113919 DOI: 10.1128/Jvi.78.10.5402-5413.2004  0.777
2004 Xu H, Svarovskaia ES, Barr R, Zhang Y, Khan MA, Strebel K, Pathak VK. A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion. Proceedings of the National Academy of Sciences of the United States of America. 101: 5652-7. PMID 15054139 DOI: 10.1073/Pnas.0400830101  0.49
2004 Svarovskaia ES, Barr R, Zhang X, Pais GC, Marchand C, Pommier Y, Burke TR, Pathak VK. Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-long-terminal-repeat-circle junctions. Journal of Virology. 78: 3210-22. PMID 15016842 DOI: 10.1128/Jvi.78.7.3210-3222.2004  0.527
2004 Dang Q, Chen J, Unutmaz D, Coffin JM, Pathak VK, Powell D, KewalRamani VN, Maldarelli F, Hu WS. Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways. Proceedings of the National Academy of Sciences of the United States of America. 101: 632-7. PMID 14707263 DOI: 10.1073/Pnas.0307636100  0.388
2003 Voronin YA, Pathak VK. Frequent dual initiation of reverse transcription in murine leukemia virus-based vectors containing two primer-binding sites. Virology. 312: 281-94. PMID 12919734 DOI: 10.1016/S0042-6822(03)00300-3  0.76
2003 Zhang X, Pais GC, Svarovskaia ES, Marchand C, Johnson AA, Karki RG, Nicklaus MC, Pathak VK, Pommier Y, Burke TR. Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 1215-9. PMID 12643946 DOI: 10.1016/S0960-894X(03)00059-3  0.389
2003 Svarovskaia ES, Cheslock SR, Zhang WH, Hu WS, Pathak VK. Retroviral mutation rates and reverse transcriptase fidelity. Frontiers in Bioscience : a Journal and Virtual Library. 8: d117-34. PMID 12456349 DOI: 10.2741/957  0.603
2003 Hu WS, Rhodes T, Dang Q, Pathak V. Retroviral recombination: review of genetic analyses. Frontiers in Bioscience : a Journal and Virtual Library. 8: d143-55. PMID 12456341 DOI: 10.2741/940  0.496
2002 Zhang WH, Svarovskaia ES, Barr R, Pathak VK. Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine-thymine tracts. Proceedings of the National Academy of Sciences of the United States of America. 99: 10090-5. PMID 12119402 DOI: 10.1073/Pnas.152186199  0.646
2002 Pais GC, Zhang X, Marchand C, Neamati N, Cowansage K, Svarovskaia ES, Pathak VK, Tang Y, Nicklaus M, Pommier Y, Burke TR. Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors. Journal of Medicinal Chemistry. 45: 3184-94. PMID 12109903 DOI: 10.1021/Jm020037P  0.386
2002 Zhang WH, Hwang CK, Hu WS, Gorelick RJ, Pathak VK. Zinc finger domain of murine leukemia virus nucleocapsid protein enhances the rate of viral DNA synthesis in vivo. Journal of Virology. 76: 7473-84. PMID 12097560 DOI: 10.1128/Jvi.76.15.7473-7484.2002  0.731
2001 Hwang CK, Svarovskaia ES, Pathak VK. Dynamic copy choice: steady state between murine leukemia virus polymerase and polymerase-dependent RNase H activity determines frequency of in vivo template switching. Proceedings of the National Academy of Sciences of the United States of America. 98: 12209-14. PMID 11593039 DOI: 10.1073/Pnas.221289898  0.622
2000 Halvas EK, Svarovskaia ES, Pathak VK. Role of murine leukemia virus reverse transcriptase deoxyribonucleoside triphosphate-binding site in retroviral replication and in vivo fidelity. Journal of Virology. 74: 10349-58. PMID 11044079 DOI: 10.1128/Jvi.74.22.10349-10358.2000  0.744
2000 Cheslock SR, Anderson JA, Hwang CK, Pathak VK, Hu WS. Utilization of nonviral sequences for minus-strand DNA transfer and gene reconstitution during retroviral replication. Journal of Virology. 74: 9571-9. PMID 11000228 DOI: 10.1128/Jvi.74.20.9571-9579.2000  0.609
2000 Svarovskaia ES, Delviks KA, Hwang CK, Pathak VK. Structural determinants of murine leukemia virus reverse transcriptase that affect the frequency of template switching. Journal of Virology. 74: 7171-8. PMID 10888659 DOI: 10.1128/Jvi.74.15.7171-7178.2000  0.649
2000 Anderson JA, Pathak VK, Hu WS. Effect of the murine leukemia virus extended packaging signal on the rates and locations of retroviral recombination. Journal of Virology. 74: 6953-63. PMID 10888634 DOI: 10.1128/Jvi.74.15.6953-6963.2000  0.447
2000 Halvas EK, Svarovskaia ES, Freed EO, Pathak VK. Wild-type and YMDD mutant murine leukemia virus reverse transcriptases are resistant to 2',3'-dideoxy-3'-thiacytidine. Journal of Virology. 74: 6669-74. PMID 10864683 DOI: 10.1128/Jvi.74.14.6669-6674.2000  0.74
2000 Halvas EK, Svarovskaia ES, Pathak VK. Development of an in vivo assay to identify structural determinants in murine leukemia virus reverse transcriptase important for fidelity. Journal of Virology. 74: 312-9. PMID 10590119 DOI: 10.1128/Jvi.74.1.312-319.2000  0.738
1999 Delviks KA, Pathak VK. Development of murine leukemia virus-based self-activating vectors that efficiently delete the selectable drug resistance gene during reverse transcription Journal of Virology. 73: 8837-8842. PMID 10482640 DOI: 10.1128/Jvi.73.10.8837-8842.1999  0.342
1999 Delviks KA, Pathak VK. Effect of distance between homologous sequences and 3' homology on the frequency of retroviral reverse transcriptase template switching Journal of Virology. 73: 7923-7932. PMID 10482539 DOI: 10.1128/Jvi.73.10.7923-7932.1999  0.382
1998 Julias JG, Pathak VK. Deoxyribonucleoside triphosphate pool imbalances in vivo are associated with an increased retroviral mutation rate Journal of Virology. 72: 7941-7949. PMID 9733832 DOI: 10.1128/Jvi.72.10.7941-7949.1998  0.408
1998 Bowman RR, Hu WS, Pathak VK. Relative rates of retroviral reverse transcriptase template switching during RNA- and DNA-dependent DNA synthesis Journal of Virology. 72: 5198-5206. PMID 9573292 DOI: 10.1128/Jvi.72.6.5198-5206.1998  0.45
1997 Delviks KA, Hu WS, Pathak VK. Ψ- vectors: Murine leukemia virus-based self-inactivating and self- activating retroviral vectors Journal of Virology. 71: 6218-6224. PMID 9223521 DOI: 10.1128/Jvi.71.8.6218-6224.1997  0.4
1997 Hu WS, Bowman EH, Delviks KA, Pathak VK. Homologous recombination occurs in a distinct retroviral subpopulation and exhibits high negative interference Journal of Virology. 71: 6028-6036. PMID 9223494 DOI: 10.1128/Jvi.71.8.6028-6036.1997  0.431
1997 Julias JG, Kim T, Arnold G, Pathak VK. The antiretrovirus drug 3'-azido-3'-deoxythymidine increases the retrovirus mutation rate Journal of Virology. 71: 4254-4263. PMID 9151812 DOI: 10.1128/Jvi.71.6.4254-4263.1997  0.491
1997 Yin PD, Pathak VK, Rowan AE, Teufel RJ, Hu WS. Utilization of nonhomologous minus-strand DNA transfer to generate recombinant retroviruses Journal of Virology. 71: 2487-2494. PMID 9032388 DOI: 10.1128/Jvi.71.3.2487-2494.1997  0.441
1997 Pathak VK, Hu WS. ''Might as well jump!' template switching by retroviral reverse transcriptase, defective genome formation, and recombination Seminars in Virology. 8: 141-150. DOI: 10.1006/Smvy.1997.0114  0.405
1996 Kim T, Mudry RA, Rexrode CA, Pathak VK. Retroviral mutation rates and A-to-G hypermutations during different stages of retroviral replication Journal of Virology. 70: 7594-7602. PMID 8892879 DOI: 10.1128/Jvi.70.11.7594-7602.1996  0.468
1996 Bowman EH, Pathak VK, Hu WS. Efficient initiation and strand transfer of polypurine tract-primed plus-strand DNA prevent strand transfer of internally initiated plus-strand DNAs Journal of Virology. 70: 1687-1694. PMID 8627689 DOI: 10.1128/Jvi.70.3.1687-1694.1996  0.382
1995 Julias JG, Hash D, Pathak VK. E- vectors: Development of novel self-inactivating and self-activating retroviral vectors for safer gene therapy Journal of Virology. 69: 6839-6846. PMID 7474097 DOI: 10.1128/Jvi.69.11.6839-6846.1995  0.407
1993 Hu W, Pathak VK, Temin HM. 13 Role of Reverse Transcriptase in Retroviral Recombination Cold Spring Harbor Monograph Archive. 23: 251-274. DOI: 10.1101/087969382.23.251  0.377
1992 Pathak VK, Temin HM. 5-Azacytidine and RNA secondary structure increase the retrovirus mutation rate Journal of Virology. 66: 3093-3100. PMID 1373201 DOI: 10.1128/Jvi.66.5.3093-3100.1992  0.428
1990 Pathak VK, Temin HM. Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: Substitutions, frameshifts, and hypermutations Proceedings of the National Academy of Sciences of the United States of America. 87: 6019-6023. PMID 2201018 DOI: 10.1073/Pnas.87.16.6019  0.418
1990 Pathak VK, Temin HM. Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: Deletions and deletions with insertions Proceedings of the National Academy of Sciences of the United States of America. 87: 6024-6028. PMID 2166940 DOI: 10.1073/Pnas.87.16.6024  0.454
1988 Pathak VK, Schindler D, Hershey JW. Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases. Molecular and Cellular Biology. 8: 993-5. PMID 3352609 DOI: 10.1128/Mcb.8.2.993  0.322
1988 Pathak VK, Nielsen PJ, Trachsel H, Hershey JW. Structure of the beta subunit of translational initiation factor eIF-2. Cell. 54: 633-9. PMID 3044606 DOI: 10.1016/S0092-8674(88)80007-2  0.323
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