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John J. Mekalanos - Publications

Affiliations: 
Microbiology and Immunobiology Harvard University, Cambridge, MA, United States 
Area:
biochemical and genetic analysis of bacterial virulence factors
Website:
http://mbib.med.harvard.edu/faculty/mekalanos.html
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272 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Pons S, Frapy E, Sereme Y, Gaultier C, Lebreton F, Kropec A, Danilchanka O, Schlemmer L, Schrimpf C, Allain M, Angoulvant F, Lecuyer H, Bonacorsi S, Aschard H, Sokol H, ... ... Mekalanos JJ, et al. A high-throughput sequencing approach identifies immunotherapeutic targets for bacterial meningitis in neonates. Ebiomedicine. 88: 104439. PMID 36709579 DOI: 10.1016/j.ebiom.2023.104439  0.757
2022 Rivera-Chávez F, Meader BT, Akosman S, Koprivica V, Mekalanos JJ. A Potent Inhibitor of the Cystic Fibrosis Transmembrane Conductance Regulator Blocks Disease and Morbidity Due to Toxigenic . Toxins. 14. PMID 35324722 DOI: 10.3390/toxins14030225  0.753
2021 Manera K, Caro F, Li H, Pei TT, Hersch SJ, Mekalanos JJ, Dong TG. Sensing of intracellular Hcp levels controls T6SS expression in . Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34161288 DOI: 10.1073/pnas.2104813118  0.334
2020 Caro F, Caro JA, Place NM, Mekalanos JJ. Transcriptional Silencing by TsrA in the Evolution of Pathogenic Vibrio cholerae Biotypes. Mbio. 11. PMID 33234688 DOI: 10.1128/mBio.02901-20  0.388
2020 Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ. CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell. PMID 32544385 DOI: 10.1016/J.Cell.2020.05.019  0.345
2020 Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ, Kranzusch PJ, Jain M, Pogliano J, Corbett KD. Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Molecular Cell. PMID 31932164 DOI: 10.1016/J.Molcel.2019.12.010  0.376
2019 Liang X, Kamal F, Pei TT, Xu P, Mekalanos JJ, Dong TG. An onboard checking mechanism ensures effector delivery of the type VI secretion system in . Proceedings of the National Academy of Sciences of the United States of America. PMID 31659021 DOI: 10.1073/Pnas.1914202116  0.382
2019 Pincus NB, Bachta KER, Ozer EA, Allen JP, Pura ON, Qi C, Rhodes NJ, Marty FM, Pandit A, Mekalanos JJ, Oliver A, Hauser AR. Long-term Persistence of an Extensively Drug Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 31583403 DOI: 10.1093/Cid/Ciz973  0.304
2019 Caro F, Place NM, Mekalanos JJ. Analysis of lipoprotein transport depletion in using CRISPRi. Proceedings of the National Academy of Sciences of the United States of America. PMID 31371515 DOI: 10.1073/Pnas.1906158116  0.412
2019 Rivera-Chávez F, Mekalanos JJ. Cholera toxin promotes pathogen acquisition of host-derived nutrients. Nature. 572: 244-248. PMID 31367037 DOI: 10.1038/S41586-019-1453-3  0.793
2019 Ji X, Zou J, Peng H, Stolle AS, Xie R, Zhang H, Peng B, Mekalanos JJ, Zheng J. Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 31004054 DOI: 10.1073/Pnas.1822026116  0.353
2019 Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ. Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature. PMID 30787435 DOI: 10.1038/S41586-019-0953-5  0.754
2019 Pincus NB, Bachta KER, Ozer EA, Allen JP, Pura ON, Marty FM, Pandit A, Mekalanos JJ, Hauser AR. 2453. Prolonged Local Epidemic of an XDR P. aeruginosa Subclade of High-Risk Clonal Complex 298 Open Forum Infectious Diseases. 6: S848-S848. DOI: 10.1093/Ofid/Ofz360.2131  0.353
2018 Toska J, Ho BT, Mekalanos JJ. Exopolysaccharide protects from exogenous attacks by the type 6 secretion system. Proceedings of the National Academy of Sciences of the United States of America. PMID 30021850 DOI: 10.1073/Pnas.1808469115  0.619
2018 Kamareddine L, Robins WP, Berkey CD, Mekalanos JJ, Watnick PI. The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism. Cell Metabolism. PMID 29937377 DOI: 10.1016/J.Cmet.2018.05.026  0.353
2018 Zheng S, Sham LT, Rubino FA, Brock KP, Robins WP, Mekalanos JJ, Marks DS, Bernhardt TG, Kruse AC. Structure and mutagenic analysis of the lipid II flippase MurJ from . Proceedings of the National Academy of Sciences of the United States of America. PMID 29891673 DOI: 10.1073/Pnas.1802192115  0.339
2018 LaPorte JP, Spinard EJ, Gomez-Chiarri M, Rowley DC, Mekalanos JJ, Nelson DR. Draft Genome Sequence of Bowmanella denitrificans JL63, a Bacterium Isolated from Whiteleg Shrimp (Litopenaeus vannamei) That Can Inhibit the Growth of Vibrio parahaemolyticus. Genome Announcements. 6. PMID 29622614 DOI: 10.1128/Genomea.00215-18  0.378
2018 Fu Y, Ho BT, Mekalanos JJ. Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments. Cell Host & Microbe. PMID 29398650 DOI: 10.1016/J.Chom.2017.12.006  0.621
2018 Zhao W, Caro F, Robins W, Mekalanos JJ. Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence. Science (New York, N.Y.). 359: 210-213. PMID 29326272 DOI: 10.1126/Science.Aap8775  0.438
2017 Ho BT, Fu Y, Dong TG, Mekalanos JJ. Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 28808000 DOI: 10.1073/Pnas.1711219114  0.623
2017 Kongrueng J, Mitraparp-Arthorn P, Bangpanwimon K, Robins W, Vuddhakul V, Mekalanos J. Isolation of Bdellovibrio and like organisms and potential to reduce acute hepatopancreatic necrosis disease caused by Vibrio parahaemolyticus. Diseases of Aquatic Organisms. 124: 223-232. PMID 28492178 DOI: 10.3354/Dao03120  0.376
2016 Hoque MM, Naser IB, Bari SM, Zhu J, Mekalanos JJ, Faruque SM. Quorum Regulated Resistance of Vibrio cholerae against Environmental Bacteriophages. Scientific Reports. 6: 37956. PMID 27892495 DOI: 10.1038/Srep37956  0.495
2016 Meeske AJ, Riley EP, Robins WP, Uehara T, Mekalanos JJ, Kahne D, Walker S, Kruse AC, Bernhardt TG, Rudner DZ. SEDS proteins are a widespread family of bacterial cell wall polymerases. Nature. PMID 27525505 DOI: 10.1038/Nature19331  0.348
2016 Del Tordello E, Danilchanka O, McCluskey AJ, Mekalanos JJ. Type VI secretion system sheaths as nanoparticles for antigen display. Proceedings of the National Academy of Sciences of the United States of America. PMID 26929342 DOI: 10.1073/Pnas.1524290113  0.75
2015 Skurnik D, Clermont O, Guillard T, Launay A, Danilchanka O, Pons S, Diancourt L, Lebreton F, Kadlec K, Roux D, Jiang D, Dion S, Achard H, Denamur M, Cywes-Bentley C, ... ... Mekalanos J, et al. Emergence of Antimicrobial Resistant Escherichia coli of Animal Origin Spreading in Humans. Molecular Biology and Evolution. PMID 26613786 DOI: 10.1093/Molbev/Msv280  0.779
2015 Roux D, Danilchanka O, Guillard T, Cattoir V, Aschard H, Fu Y, Angoulvant F, Messika J, Ricard JD, Mekalanos JJ, Lory S, Pier GB, Skurnik D. Fitness cost of antibiotic susceptibility during bacterial infection. Science Translational Medicine. 7: 297ra114. PMID 26203082 DOI: 10.1126/Scitranslmed.Aab1621  0.777
2015 Altindis E, Dong T, Catalano C, Mekalanos J. Secretome analysis of Vibrio cholerae type VI secretion system reveals a new effector-immunity pair. Mbio. 6: e00075. PMID 25759499 DOI: 10.1128/Mbio.00075-15  0.458
2015 Thanawastien A, Cartee RT, Griffin TJ, Killeen KP, Mekalanos JJ. Conjugate-like immunogens produced as protein capsular matrix vaccines. Proceedings of the National Academy of Sciences of the United States of America. 112: E1143-51. PMID 25699685 DOI: 10.1073/Pnas.1425005112  0.302
2015 Dong TG, Dong S, Catalano C, Moore R, Liang X, Mekalanos JJ. Generation of reactive oxygen species by lethal attacks from competing microbes. Proceedings of the National Academy of Sciences of the United States of America. 112: 2181-6. PMID 25646446 DOI: 10.1073/Pnas.1425007112  0.32
2014 Hang S, Purdy AE, Robins WP, Wang Z, Mandal M, Chang S, Mekalanos JJ, Watnick PI. The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. Cell Host & Microbe. 16: 592-604. PMID 25525791 DOI: 10.1016/J.Chom.2014.10.006  0.363
2014 Suzuki M, Danilchanka O, Mekalanos JJ. Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases. Cell Host & Microbe. 16: 581-91. PMID 25450857 DOI: 10.1016/J.Chom.2014.09.015  0.756
2014 Kamruzzaman M, Robins WP, Bari SM, Nahar S, Mekalanos JJ, Faruque SM. RS1 satellite phage promotes diversity of toxigenic Vibrio cholerae by driving CTX prophage loss and elimination of lysogenic immunity. Infection and Immunity. 82: 3636-43. PMID 24935981 DOI: 10.1128/Iai.01699-14  0.453
2014 Vercruysse M, Köhrer C, Davies BW, Arnold MF, Mekalanos JJ, RajBhandary UL, Walker GC. The highly conserved bacterial RNase YbeY is essential in vibrio cholerae, playing a critical role in virulence, stress regulation, and RNA processing. Plos Pathogens. 10: e1004175. PMID 24901994 DOI: 10.1371/Journal.Ppat.1004175  0.42
2014 Altindis E, Fu Y, Mekalanos JJ. Proteomic analysis of Vibrio cholerae outer membrane vesicles. Proceedings of the National Academy of Sciences of the United States of America. 111: E1548-56. PMID 24706774 DOI: 10.1073/Pnas.1403683111  0.41
2014 Yingkajorn M, Sermwitayawong N, Palittapongarnpimp P, Nishibuchi M, Robins WP, Mekalanos JJ, Vuddhakul V. Vibrio parahaemolyticus and its specific bacteriophages as an indicator in cockles (Anadara granosa) for the risk of V. parahaemolyticus infection in Southern Thailand. Microbial Ecology. 67: 849-56. PMID 24682339 DOI: 10.1007/S00248-014-0382-9  0.334
2014 Robins WP, Mekalanos JJ. Genomic science in understanding cholera outbreaks and evolution of Vibrio cholerae as a human pathogen. Current Topics in Microbiology and Immunology. 379: 211-29. PMID 24590676 DOI: 10.1007/82_2014_366  0.377
2014 Ho BT, Dong TG, Mekalanos JJ. A view to a kill: the bacterial type VI secretion system. Cell Host & Microbe. 15: 9-21. PMID 24332978 DOI: 10.1016/J.Chom.2013.11.008  0.614
2014 Shneider M, Buth S, Ho B, Basler M, Mekalanos J, Leiman P. Central spike proteins of contractile ejection systems Acta Crystallographica Section a Foundations and Advances. 70: C579-C579. DOI: 10.1107/S2053273314094200  0.556
2013 Fu Y, Waldor MK, Mekalanos JJ. Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. Cell Host & Microbe. 14: 652-63. PMID 24331463 DOI: 10.1016/J.Chom.2013.11.001  0.501
2013 Skurnik D, Roux D, Cattoir V, Danilchanka O, Lu X, Yoder-Himes DR, Han K, Guillard T, Jiang D, Gaultier C, Guerin F, Aschard H, Leclercq R, Mekalanos JJ, Lory S, et al. Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing. Proceedings of the National Academy of Sciences of the United States of America. 110: 20747-52. PMID 24248354 DOI: 10.1073/Pnas.1221552110  0.779
2013 Ho BT, Basler M, Mekalanos JJ. Type 6 secretion system-mediated immunity to type 4 secretion system-mediated gene transfer. Science (New York, N.Y.). 342: 250-3. PMID 24115441 DOI: 10.1126/Science.1243745  0.626
2013 Danilchanka O, Mekalanos JJ. Cyclic dinucleotides and the innate immune response. Cell. 154: 962-70. PMID 23993090 DOI: 10.1016/J.Cell.2013.08.014  0.748
2013 Shneider MM, Buth SA, Ho BT, Basler M, Mekalanos JJ, Leiman PG. PAAR-repeat proteins sharpen and diversify the type VI secretion system spike. Nature. 500: 350-3. PMID 23925114 DOI: 10.1038/Nature12453  0.587
2013 Bari SM, Roky MK, Mohiuddin M, Kamruzzaman M, Mekalanos JJ, Faruque SM. Quorum-sensing autoinducers resuscitate dormant Vibrio cholerae in environmental water samples. Proceedings of the National Academy of Sciences of the United States of America. 110: 9926-31. PMID 23716683 DOI: 10.1073/Pnas.1307697110  0.403
2013 Basler M, Ho BT, Mekalanos JJ. Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions. Cell. 152: 884-94. PMID 23415234 DOI: 10.1016/J.Cell.2013.01.042  0.592
2013 Robins WP, Faruque SM, Mekalanos JJ. Coupling mutagenesis and parallel deep sequencing to probe essential residues in a genome or gene. Proceedings of the National Academy of Sciences of the United States of America. 110: E848-57. PMID 23401533 DOI: 10.1073/Pnas.1222538110  0.342
2013 Dong TG, Ho BT, Yoder-Himes DR, Mekalanos JJ. Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae. Proceedings of the National Academy of Sciences of the United States of America. 110: 2623-8. PMID 23362380 DOI: 10.1073/Pnas.1222783110  0.631
2012 Faruque SM, Mekalanos JJ. Phage-bacterial interactions in the evolution of toxigenic Vibrio cholerae. Virulence. 3: 556-65. PMID 23076327 DOI: 10.4161/Viru.22351  0.476
2012 Mekalanos JJ, Robins W, Ussery DW, Davis BM, Schadt E, Waldor MK. Non-O1 Vibrio cholerae unlinked to cholera in Haiti. Proceedings of the National Academy of Sciences of the United States of America. 109: E3206; author reply . PMID 23035253 DOI: 10.1073/Pnas.1212443109  0.351
2012 Seed KD, Faruque SM, Mekalanos JJ, Calderwood SB, Qadri F, Camilli A. Phase variable O antigen biosynthetic genes control expression of the major protective antigen and bacteriophage receptor in Vibrio cholerae O1. Plos Pathogens. 8: e1002917. PMID 23028317 DOI: 10.1371/Journal.Ppat.1002917  0.337
2012 Bogard RW, Davies BW, Mekalanos JJ. MetR-regulated Vibrio cholerae metabolism is required for virulence. Mbio. 3. PMID 23015737 DOI: 10.1128/Mbio.00236-12  0.412
2012 Dong TG, Mekalanos JJ. Characterization of the RpoN regulon reveals differential regulation of T6SS and new flagellar operons in Vibrio cholerae O37 strain V52. Nucleic Acids Research. 40: 7766-75. PMID 22723378 DOI: 10.1093/Nar/Gks567  0.44
2012 Davies BW, Bogard RW, Young TS, Mekalanos JJ. Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence. Cell. 149: 358-70. PMID 22500802 DOI: 10.1016/J.Cell.2012.01.053  0.434
2012 Rattanama P, Thompson JR, Kongkerd N, Srinitiwarawong K, Vuddhakul V, Mekalanos JJ. Sigma E regulators control hemolytic activity and virulence in a shrimp pathogenic Vibrio harveyi. Plos One. 7: e32523. PMID 22384269 DOI: 10.1371/Journal.Pone.0032523  0.499
2012 Basler M, Pilhofer M, Henderson GP, Jensen GJ, Mekalanos JJ. Type VI secretion requires a dynamic contractile phage tail-like structure. Nature. 483: 182-6. PMID 22367545 DOI: 10.1038/Nature10846  0.332
2012 Rattanama P, Thompson JR, Kongkerd N, Srinitiwarawong K, Vuddhakul V, Mekalanos JJ. Correction: Sigma E Regulators Control Hemolytic Activity and Virulence in a Shrimp Pathogenic Vibrio harveyi Plos One. 7. DOI: 10.1371/Annotation/De7188A8-1565-41Fa-Bc0C-418Ea1Bf8F44  0.342
2012 Basler M, Mekalanos JJ. Type 6 secretion dynamics within and between bacterial cells Science. 337: 815. DOI: 10.1126/Science.1222901  0.361
2011 Zheng J, Ho B, Mekalanos JJ. Genetic analysis of anti-amoebae and anti-bacterial activities of the type VI secretion system in Vibrio cholerae. Plos One. 6: e23876. PMID 21909372 DOI: 10.1371/Journal.Pone.0023876  0.694
2011 Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB. Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient. Frontiers in Microbiology. 2: 162. PMID 21863142 DOI: 10.3389/Fmicb.2011.00162  0.376
2011 Mandlik A, Livny J, Robins WP, Ritchie JM, Mekalanos JJ, Waldor MK. RNA-Seq-based monitoring of infection-linked changes in Vibrio cholerae gene expression. Cell Host & Microbe. 10: 165-74. PMID 21843873 DOI: 10.1016/J.Chom.2011.07.007  0.391
2011 Davies BW, Bogard RW, Mekalanos JJ. Mapping the regulon of Vibrio cholerae ferric uptake regulator expands its known network of gene regulation. Proceedings of the National Academy of Sciences of the United States of America. 108: 12467-72. PMID 21750152 DOI: 10.1073/Pnas.1107894108  0.367
2011 Shin OS, Tam VC, Suzuki M, Ritchie JM, Bronson RT, Waldor MK, Mekalanos JJ. Type III secretion is essential for the rapidly fatal diarrheal disease caused by non-O1, non-O139 Vibrio cholerae. Mbio. 2: e00106-11. PMID 21673189 DOI: 10.1128/Mbio.00106-11  0.687
2011 Davies BW, Bogard RW, Dupes NM, Gerstenfeld TA, Simmons LA, Mekalanos JJ. DNA damage and reactive nitrogen species are barriers to Vibrio cholerae colonization of the infant mouse intestine. Plos Pathogens. 7: e1001295. PMID 21379340 DOI: 10.1371/Journal.Ppat.1001295  0.342
2011 Chin CS, Sorenson J, Harris JB, Robins WP, Charles RC, Jean-Charles RR, Bullard J, Webster DR, Kasarskis A, Peluso P, Paxinos EE, Yamaichi Y, Calderwood SB, Mekalanos JJ, Schadt EE, et al. The origin of the Haitian cholera outbreak strain. The New England Journal of Medicine. 364: 33-42. PMID 21142692 DOI: 10.1056/Nejmoa1012928  0.317
2011 Cameron DE, Mekalanos JJ. Live attenuated cholera vaccines: Flagella and reactogenicity Birkhauser Advances in Infectious Diseases. 261-281. DOI: 10.1007/978-3-0346-0277-8_11  0.485
2010 Tam VC, Suzuki M, Coughlin M, Saslowsky D, Biswas K, Lencer WI, Faruque SM, Mekalanos JJ. Functional analysis of VopF activity required for colonization in Vibrio cholerae. Mbio. 1. PMID 21151774 DOI: 10.1128/Mbio.00289-10  0.716
2010 Zheng J, Shin OS, Cameron DE, Mekalanos JJ. Quorum sensing and a global regulator TsrA control expression of type VI secretion and virulence in Vibrio cholerae. Proceedings of the National Academy of Sciences of the United States of America. 107: 21128-33. PMID 21084635 DOI: 10.1073/Pnas.1014998107  0.644
2010 Hassan F, Kamruzzaman M, Mekalanos JJ, Faruque SM. Satellite phage TLCφ enables toxigenic conversion by CTX phage through dif site alteration. Nature. 467: 982-5. PMID 20944629 DOI: 10.1038/Nature09469  0.397
2010 Zahid MS, Waise TM, Kamruzzaman M, Ghosh AN, Nair GB, Mekalanos JJ, Faruque SM. The cyclic AMP (cAMP)-cAMP receptor protein signaling system mediates resistance of Vibrio cholerae O1 strains to multiple environmental bacteriophages. Applied and Environmental Microbiology. 76: 4233-40. PMID 20472740 DOI: 10.1128/Aem.00008-10  0.456
2010 Rui H, Ritchie JM, Bronson RT, Mekalanos JJ, Zhang Y, Waldor MK. Reactogenicity of live-attenuated Vibrio cholerae vaccines is dependent on flagellins. Proceedings of the National Academy of Sciences of the United States of America. 107: 4359-64. PMID 20160087 DOI: 10.1073/Pnas.0915164107  0.443
2010 Ma AT, Mekalanos JJ. In vivo actin cross-linking induced by Vibrio cholerae type VI secretion system is associated with intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America. 107: 4365-70. PMID 20150509 DOI: 10.1073/Pnas.0915156107  0.445
2010 Kamruzzaman M, Udden SM, Cameron DE, Calderwood SB, Nair GB, Mekalanos JJ, Faruque SM. Quorum-regulated biofilms enhance the development of conditionally viable, environmental Vibrio cholerae. Proceedings of the National Academy of Sciences of the United States of America. 107: 1588-93. PMID 20080633 DOI: 10.1073/Pnas.0913404107  0.624
2009 Thanawastien A, Montor WR, Labaer J, Mekalanos JJ, Yoon SS. Vibrio cholerae proteome-wide screen for immunostimulatory proteins identifies phosphatidylserine decarboxylase as a novel Toll-like receptor 4 agonist. Plos Pathogens. 5: e1000556. PMID 19696891 DOI: 10.1371/Journal.Ppat.1000556  0.349
2009 Ma AT, McAuley S, Pukatzki S, Mekalanos JJ. Translocation of a Vibrio cholerae type VI secretion effector requires bacterial endocytosis by host cells. Cell Host & Microbe. 5: 234-43. PMID 19286133 DOI: 10.1016/J.Chom.2009.02.005  0.72
2009 Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ. Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin. Proceedings of the National Academy of Sciences of the United States of America. 106: 4154-9. PMID 19251641 DOI: 10.1073/Pnas.0813360106  0.703
2008 Zahid MS, Udden SM, Faruque AS, Calderwood SB, Mekalanos JJ, Faruque SM. Effect of phage on the infectivity of Vibrio cholerae and emergence of genetic variants. Infection and Immunity. 76: 5266-73. PMID 18794293 DOI: 10.1128/Iai.00578-08  0.433
2008 Udden SM, Zahid MS, Biswas K, Ahmad QS, Cravioto A, Nair GB, Mekalanos JJ, Faruque SM. Acquisition of classical CTX prophage from Vibrio cholerae O141 by El Tor strains aided by lytic phages and chitin-induced competence. Proceedings of the National Academy of Sciences of the United States of America. 105: 11951-6. PMID 18689675 DOI: 10.1073/Pnas.0805560105  0.399
2008 Rhie GE, Jung HM, Kim BS, Mekalanos JJ. Construction of a Vibrio cholerae prototype vaccine strain O395-N1-E1 which accumulates cell-associated cholera toxin B subunit. Vaccine. 26: 5443-8. PMID 18582519 DOI: 10.1016/J.Vaccine.2008.05.088  0.349
2008 Cameron DE, Urbach JM, Mekalanos JJ. A defined transposon mutant library and its use in identifying motility genes in Vibrio cholerae. Proceedings of the National Academy of Sciences of the United States of America. 105: 8736-41. PMID 18574146 DOI: 10.1073/pnas.0803281105  0.599
2008 Rahman MH, Biswas K, Hossain MA, Sack RB, Mekalanos JJ, Faruque SM. Distribution of genes for virulence and ecological fitness among diverse Vibrio cholerae population in a cholera endemic area: tracking the evolution of pathogenic strains. Dna and Cell Biology. 27: 347-55. PMID 18462070 DOI: 10.1089/Dna.2008.0737  0.426
2008 Rolfs A, Montor WR, Yoon SS, Hu Y, Bhullar B, Kelley F, McCarron S, Jepson DA, Shen B, Taycher E, Mohr SE, Zuo D, Williamson J, Mekalanos J, Labaer J. Production and sequence validation of a complete full length ORF collection for the pathogenic bacterium Vibrio cholerae. Proceedings of the National Academy of Sciences of the United States of America. 105: 4364-9. PMID 18337508 DOI: 10.1073/Pnas.0712049105  0.403
2008 Yoon SS, Mekalanos JJ. Decreased potency of the Vibrio cholerae sheathed flagellum to trigger host innate immunity. Infection and Immunity. 76: 1282-8. PMID 18174340 DOI: 10.1128/Iai.00736-07  0.407
2008 Rhie GE, Jung HM, Park J, Kim BS, Mekalanos JJ. Construction of cholera toxin B subunit-producing Vibrio cholerae strains using the Mariner-FRT transposon delivery system. Fems Immunology and Medical Microbiology. 52: 23-8. PMID 18070076 DOI: 10.1111/J.1574-695X.2007.00346.X  0.413
2007 Tam VC, Serruto D, Dziejman M, Brieher W, Mekalanos JJ. A type III secretion system in Vibrio cholerae translocates a formin/spire hybrid-like actin nucleator to promote intestinal colonization. Cell Host & Microbe. 1: 95-107. PMID 18005688 DOI: 10.1016/J.Chom.2007.03.005  0.709
2007 Shakhnovich EA, Sturtevant D, Mekalanos JJ. Molecular mechanisms of virstatin resistance by non-O1/non-O139 strains of Vibrio cholerae. Molecular Microbiology. 66: 1331-41. PMID 17986190 DOI: 10.1111/J.1365-2958.2007.05984.X  0.8
2007 Pukatzki S, Ma AT, Revel AT, Sturtevant D, Mekalanos JJ. Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin. Proceedings of the National Academy of Sciences of the United States of America. 104: 15508-13. PMID 17873062 DOI: 10.1073/Pnas.0706532104  0.719
2007 Mougous JD, Gifford CA, Ramsdell TL, Mekalanos JJ. Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa. Nature Cell Biology. 9: 797-803. PMID 17558395 DOI: 10.1038/Ncb1605  0.345
2007 Raskin DM, Judson N, Mekalanos JJ. Regulation of the stringent response is the essential function of the conserved bacterial G protein CgtA in Vibrio cholerae. Proceedings of the National Academy of Sciences of the United States of America. 104: 4636-41. PMID 17360576 DOI: 10.1073/Pnas.0611650104  0.799
2007 Faruque SM, Tam VC, Chowdhury N, Diraphat P, Dziejman M, Heidelberg JF, Clemens JD, Mekalanos JJ, Nair GB. Genomic analysis of the Mozambique strain of Vibrio cholerae O1 reveals the origin of El Tor strains carrying classical CTX prophage. Proceedings of the National Academy of Sciences of the United States of America. 104: 5151-6. PMID 17360342 DOI: 10.1073/Pnas.0700365104  0.692
2007 Smith MG, Gianoulis TA, Pukatzki S, Mekalanos JJ, Ornston LN, Gerstein M, Snyder M. New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis. Genes & Development. 21: 601-14. PMID 17344419 DOI: 10.1101/gad.1510307  0.711
2007 Shakhnovich EA, Hung DT, Pierson E, Lee K, Mekalanos JJ. Virstatin inhibits dimerization of the transcriptional activator ToxT Proceedings of the National Academy of Sciences of the United States of America. 104: 2372-2377. PMID 17283330 DOI: 10.1073/Pnas.0611643104  0.811
2006 Yoon SS, Mekalanos JJ. 2,3-butanediol synthesis and the emergence of the Vibrio cholerae El Tor biotype. Infection and Immunity. 74: 6547-56. PMID 17015461 DOI: 10.1128/Iai.00695-06  0.398
2006 Bina JE, Provenzano D, Wang C, Bina XR, Mekalanos JJ. Characterization of the Vibrio cholerae vexAB and vexCD efflux systems. Archives of Microbiology. 186: 171-81. PMID 16804679 DOI: 10.1007/S00203-006-0133-5  0.807
2006 Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordoñez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ. A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science (New York, N.Y.). 312: 1526-30. PMID 16763151 DOI: 10.1126/Science.1128393  0.398
2006 Faruque SM, Biswas K, Udden SM, Ahmad QS, Sack DA, Nair GB, Mekalanos JJ. Transmissibility of cholera: in vivo-formed biofilms and their relationship to infectivity and persistence in the environment. Proceedings of the National Academy of Sciences of the United States of America. 103: 6350-5. PMID 16601099 DOI: 10.1073/Pnas.0601277103  0.411
2006 Jensen MA, Faruque SM, Mekalanos JJ, Levin BR. Modeling the role of bacteriophage in the control of cholera outbreaks. Proceedings of the National Academy of Sciences of the United States of America. 103: 4652-7. PMID 16537404 DOI: 10.1073/Pnas.0600166103  0.382
2006 Faruque SM, Islam MJ, Ahmad QS, Biswas K, Faruque AS, Nair GB, Sack RB, Sack DA, Mekalanos JJ. An improved technique for isolation of environmental Vibrio cholerae with epidemic potential: monitoring the emergence of a multiple-antibiotic-resistant epidemic strain in Bangladesh. The Journal of Infectious Diseases. 193: 1029-36. PMID 16518766 DOI: 10.1086/500953  0.422
2006 Raskin DM, Seshadri R, Pukatzki SU, Mekalanos JJ. Bacterial genomics and pathogen evolution. Cell. 124: 703-14. PMID 16497582 DOI: 10.1016/J.Cell.2006.02.002  0.704
2006 Pukatzki S, Ma AT, Sturtevant D, Krastins B, Sarracino D, Nelson WC, Heidelberg JF, Mekalanos JJ. Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proceedings of the National Academy of Sciences of the United States of America. 103: 1528-33. PMID 16432199 DOI: 10.1073/Pnas.0510322103  0.766
2006 Rietsch A, Mekalanos JJ. Metabolic regulation of type III secretion gene expression in Pseudomonas aeruginosa. Molecular Microbiology. 59: 807-20. PMID 16420353 DOI: 10.1111/J.1365-2958.2005.04990.X  0.397
2006 Hung DT, Zhu J, Sturtevant D, Mekalanos JJ. Bile acids stimulate biofilm formation in Vibrio cholerae. Molecular Microbiology. 59: 193-201. PMID 16359328 DOI: 10.1111/J.1365-2958.2005.04846.X  0.643
2005 Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ. Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science (New York, N.Y.). 310: 670-4. PMID 16223984 DOI: 10.1126/Science.1116739  0.808
2005 Larocque RC, Harris JB, Dziejman M, Li X, Khan AI, Faruque AS, Faruque SM, Nair GB, Ryan ET, Qadri F, Mekalanos JJ, Calderwood SB. Transcriptional profiling of Vibrio cholerae recovered directly from patient specimens during early and late stages of human infection. Infection and Immunity. 73: 4488-93. PMID 16040959 DOI: 10.1128/Iai.73.8.4488-4493.2005  0.42
2005 Faruque SM, Bin Naser I, Fujihara K, Diraphat P, Chowdhury N, Kamruzzaman M, Qadri F, Yamasaki S, Ghosh AN, Mekalanos JJ. Genomic sequence and receptor for the Vibrio cholerae phage KSF-1phi: evolutionary divergence among filamentous vibriophages mediating lateral gene transfer. Journal of Bacteriology. 187: 4095-103. PMID 15937172 DOI: 10.1128/Jb.187.12.4095-4103.2005  0.421
2005 Rietsch A, Vallet-Gely I, Dove SL, Mekalanos JJ. ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America. 102: 8006-11. PMID 15911752 DOI: 10.1073/Pnas.0503005102  0.368
2005 Aulinger BA, Roehrl MH, Mekalanos JJ, Collier RJ, Wang JY. Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines. Infection and Immunity. 73: 3408-14. PMID 15908368 DOI: 10.1128/Iai.73.6.3408-3414.2005  0.481
2005 Faruque SM, Islam MJ, Ahmad QS, Faruque AS, Sack DA, Nair GB, Mekalanos JJ. Self-limiting nature of seasonal cholera epidemics: Role of host-mediated amplification of phage. Proceedings of the National Academy of Sciences of the United States of America. 102: 6119-24. PMID 15829587 DOI: 10.1073/Pnas.0502069102  0.403
2005 Altman S, Bassler BL, Beckwith J, Belfort M, Berg HC, Bloom B, Brenchley JE, Campbell A, Collier RJ, Connell N, Cozzarelli NR, Craig NL, Darst S, Ebright RH, Elledge SJ, ... ... Mekalanos JJ, et al. An open letter to Elias Zerhouni. Science (New York, N.Y.). 307: 1409-10. PMID 15746409 DOI: 10.1126/Science.307.5714.1409C  0.737
2005 Vance RE, Rietsch A, Mekalanos JJ. Role of the type III secreted exoenzymes S, T, and Y in systemic spread of Pseudomonas aeruginosa PAO1 in vivo. Infection and Immunity. 73: 1706-13. PMID 15731071 DOI: 10.1128/Iai.73.3.1706-1713.2005  0.625
2005 Dziejman M, Serruto D, Tam VC, Sturtevant D, Diraphat P, Faruque SM, Rahman MH, Heidelberg JF, Decker J, Li L, Montgomery KT, Grills G, Kucherlapati R, Mekalanos JJ. Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system. Proceedings of the National Academy of Sciences of the United States of America. 102: 3465-70. PMID 15728357 DOI: 10.1073/Pnas.0409918102  0.674
2005 Hung DT, Mekalanos JJ. Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner. Proceedings of the National Academy of Sciences of the United States of America. 102: 3028-33. PMID 15699331 DOI: 10.1073/Pnas.0409559102  0.64
2005 Faruque SM, Naser IB, Islam MJ, Faruque AS, Ghosh AN, Nair GB, Sack DA, Mekalanos JJ. Seasonal epidemics of cholera inversely correlate with the prevalence of environmental cholera phages. Proceedings of the National Academy of Sciences of the United States of America. 102: 1702-7. PMID 15653771 DOI: 10.1073/Pnas.0408992102  0.395
2004 Faruque SM, Nair GB, Mekalanos JJ. Genetics of stress adaptation and virulence in toxigenic Vibrio cholerae. Dna and Cell Biology. 23: 723-41. PMID 15585131 DOI: 10.1089/Dna.2004.23.723  0.455
2004 Rietsch A, Wolfgang MC, Mekalanos JJ. Effect of metabolic imbalance on expression of type III secretion genes in Pseudomonas aeruginosa. Infection and Immunity. 72: 1383-90. PMID 14977942 DOI: 10.1128/Iai.72.3.1383-1390.2004  0.39
2004 Jönsson K, Guo BP, Monstein HJ, Mekalanos JJ, Kronvall G. Molecular cloning and characterization of two Helicobacter pylori genes coding for plasminogen-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 101: 1852-7. PMID 14769936 DOI: 10.1073/Pnas.0307329101  0.365
2004 Vance RE, Hong S, Gronert K, Serhan CN, Mekalanos JJ. The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase. Proceedings of the National Academy of Sciences of the United States of America. 101: 2135-9. PMID 14766977 DOI: 10.1073/Pnas.0307308101  0.62
2004 Faruque SM, Chowdhury N, Kamruzzaman M, Dziejman M, Rahman MH, Sack DA, Nair GB, Mekalanos JJ. Genetic diversity and virulence potential of environmental Vibrio cholerae population in a cholera-endemic area. Proceedings of the National Academy of Sciences of the United States of America. 101: 2123-8. PMID 14766976 DOI: 10.1073/Pnas.0308485100  0.428
2003 Faruque SM, Mekalanos JJ. Pathogenicity islands and phages in Vibrio cholerae evolution. Trends in Microbiology. 11: 505-10. PMID 14607067 DOI: 10.1016/J.Tim.2003.09.003  0.461
2003 Zhu J, Mekalanos JJ. Quorum sensing-dependent biofilms enhance colonization in Vibrio cholerae. Developmental Cell. 5: 647-56. PMID 14536065 DOI: 10.1016/S1534-5807(03)00295-8  0.419
2003 Rhie GE, Roehrl MH, Mourez M, Collier RJ, Mekalanos JJ, Wang JY. A dually active anthrax vaccine that confers protection against both bacilli and toxins. Proceedings of the National Academy of Sciences of the United States of America. 100: 10925-30. PMID 12960361 DOI: 10.1073/Pnas.1834478100  0.489
2003 Faruque SM, Zhu J, Asadulghani, Kamruzzaman M, Mekalanos JJ. Examination of diverse toxin-coregulated pilus-positive Vibrio cholerae strains fails to demonstrate evidence for Vibrio pathogenicity island phage. Infection and Immunity. 71: 2993-9. PMID 12761075 DOI: 10.1128/Iai.71.6.2993-2999.2003  0.438
2003 Vance RE, Zhu J, Mekalanos JJ. A constitutively active variant of the quorum-sensing regulator LuxO affects protease production and biofilm formation in Vibrio cholerae. Infection and Immunity. 71: 2571-6. PMID 12704130 DOI: 10.1128/Iai.71.5.2571-2576.2003  0.654
2003 Bina J, Zhu J, Dziejman M, Faruque S, Calderwood S, Mekalanos J. ToxR regulon of Vibrio cholerae and its expression in vibrios shed by cholera patients. Proceedings of the National Academy of Sciences of the United States of America. 100: 2801-6. PMID 12601157 DOI: 10.1073/Pnas.2628026100  0.748
2003 Xu Q, Dziejman M, Mekalanos JJ. Determination of the transcriptome of Vibrio cholerae during intraintestinal growth and midexponential phase in vitro. Proceedings of the National Academy of Sciences of the United States of America. 100: 1286-91. PMID 12552086 DOI: 10.1073/Pnas.0337479100  0.413
2003 Faruque SM, Kamruzzaman M, Asadulghani, Sack DA, Mekalanos JJ, Nair GB. CTXphi-independent production of the RS1 satellite phage by Vibrio cholerae. Proceedings of the National Academy of Sciences of the United States of America. 100: 1280-5. PMID 12529504 DOI: 10.1073/Pnas.0237385100  0.411
2002 Guo BP, Mekalanos JJ. Rapid genetic analysis of Helicobacter pylori gastric mucosal colonization in suckling mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 8354-9. PMID 12060779 DOI: 10.1073/Pnas.122244899  0.393
2002 Fullner KJ, Boucher JC, Hanes MA, Haines GK, Meehan BM, Walchle C, Sansonetti PJ, Mekalanos JJ. The contribution of accessory toxins of Vibrio cholerae O1 El Tor to the proinflammatory response in a murine pulmonary cholera model. The Journal of Experimental Medicine. 195: 1455-62. PMID 12045243 DOI: 10.1084/Jem.20020318  0.418
2002 Buddelmeijer N, Judson N, Boyd D, Mekalanos JJ, Beckwith J. YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site. Proceedings of the National Academy of Sciences of the United States of America. 99: 6316-21. PMID 11972052 DOI: 10.1073/Pnas.092128499  0.791
2002 Pukatzki S, Kessin RH, Mekalanos JJ. The human pathogen Pseudomonas aeruginosa utilizes conserved virulence pathways to infect the social amoeba Dictyostelium discoideum. Proceedings of the National Academy of Sciences of the United States of America. 99: 3159-64. PMID 11867744 DOI: 10.1073/Pnas.052704399  0.816
2002 Zhu J, Miller MB, Vance RE, Dziejman M, Bassler BL, Mekalanos JJ. Quorum-sensing regulators control virulence gene expression in Vibrio cholerae. Proceedings of the National Academy of Sciences of the United States of America. 99: 3129-34. PMID 11854465 DOI: 10.1073/Pnas.052694299  0.679
2002 Dziejman M, Balon E, Boyd D, Fraser CM, Heidelberg JF, Mekalanos JJ. Comparative genomic analysis of Vibrio cholerae: genes that correlate with cholera endemic and pandemic disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 1556-61. PMID 11818571 DOI: 10.1073/Pnas.042667999  0.429
2002 Akerley BJ, Rubin EJ, Novick VL, Amaya K, Judson N, Mekalanos JJ. A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae. Proceedings of the National Academy of Sciences of the United States of America. 99: 966-71. PMID 11805338 DOI: 10.1073/Pnas.012602299  0.795
2002 Faruque SM, Asadulghani, Kamruzzaman M, Nandi RK, Ghosh AN, Nair GB, Mekalanos JJ, Sack DA. RS1 element of Vibrio cholerae can propagate horizontally as a filamentous phage exploiting the morphogenesis genes of CTXphi. Infection and Immunity. 70: 163-70. PMID 11748178 DOI: 10.1128/Iai.70.1.163-170.2002  0.395
2002 Dalsgaard A, Serichantalergs O, Forslund A, Lin W, Mekalanos J, Mintz E, Shimada T, Wells JG. Clinical and environmental isolates of Vibrio cholerae serogroup O141 carry the CTX phage and the genes encoding the toxin-coregulated pili. Journal of Clinical Microbiology. 39: 4086-92. PMID 11682534 DOI: 10.1128/Jcm.39.11.4086-4092.2001  0.377
2001 Fullner KJ, Lencer WI, Mekalanos JJ. Vibrio cholerae-induced cellular responses of polarized T84 intestinal epithelial cells are dependent on production of cholera toxin and the RTX toxin Infection and Immunity. 69: 6310-6317. PMID 11553575 DOI: 10.1128/Iai.69.10.6310-6317.2001  0.371
2001 Faruque SM, Rahman MM, Hasan AK, Nair GB, Mekalanos JJ, Sack DA. Diminished diarrheal response to Vibrio cholerae strains carrying the replicative form of the CTX(Phi) genome instead of CTX(Phi) lysogens in adult rabbits. Infection and Immunity. 69: 6084-90. PMID 11553546 DOI: 10.1128/Iai.69.10.6084-6090.2001  0.4
2001 Bina JE, Mekalanos JJ. Vibrio cholerae tolC is required for bile resistance and colonization Infection and Immunity. 69: 4681-4685. PMID 11402016 DOI: 10.1128/Iai.69.7.4681-4685.2001  0.74
2001 Guo BP, Mekalanos JJ. Helicobacter pylori mutagenesis by mariner in vitro transposition Fems Immunology and Medical Microbiology. 30: 87-93. PMID 11267839 DOI: 10.1111/J.1574-695X.2001.Tb01554.X  0.389
2001 Cassell GH, Mekalanos J. Development of antimicrobial agents in the era of new and reemerging infectious diseases and increasing antibiotic resistance. Jama. 285: 601-5. PMID 11176866 DOI: 10.1001/Jama.285.5.601  0.313
2000 Judson N, Mekalanos JJ. Transposon-based approaches to identify essential bacterial genes Trends in Microbiology. 8: 521-526. PMID 11121763 DOI: 10.1016/S0966-842X(00)01865-5  0.799
2000 Mel SF, Fullner KJ, Wimer-Mackin S, Lencer WI, Mekalanos JJ. Association of protease activity in Vibrio cholerae vaccine strains with decreases in transcellular epithelial resistance of polarized T84 intestinal epithelial cells. Infection and Immunity. 68: 6487-92. PMID 11035765 DOI: 10.1128/Iai.68.11.6487-6492.2000  0.371
2000 Chiang SL, Mekalanos JJ. Construction of a Vibrio cholerae vaccine candidate using transposon delivery and FLP recombinase-mediated excision Infection and Immunity. 68: 6391-6397. PMID 11035750 DOI: 10.1128/Iai.68.11.6391-6397.2000  0.387
2000 Fullner KJ, Mekalanos JJ. In vivo covalent cross-linking of cellular actin by the Vibrio cholerae RTX toxin Embo Journal. 19: 5315-5323. PMID 11032799 DOI: 10.1093/Emboj/19.20.5315  0.371
2000 Wong SM, Mekalanos JJ. Genetic footprinting with mariner-based transposition in Pseudomonas aeruginosa Proceedings of the National Academy of Sciences of the United States of America. 97: 10191-10196. PMID 10963681 DOI: 10.1073/Pnas.97.18.10191  0.401
2000 Heidelberg JF, Eisen JA, Nelson WC, Clayton RA, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Umayam L, Gill SR, Nelson KE, Read TD, Tettelin H, Richardson D, ... ... Mekalanos JJ, et al. DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature. 406: 477-83. PMID 10952301 DOI: 10.1038/35020000  0.389
2000 Judson N, Mekalanos JJ. TnaRaOut, a transposon-based approach to identify and characterize essential bacterial genes Nature Biotechnology. 18: 740-745. PMID 10888841 DOI: 10.1038/77305  0.812
2000 Blum JH, Dove SL, Hochschild A, Mekalanos JJ. Isolation of peptide aptamers that inhibit intracellular processes Proceedings of the National Academy of Sciences of the United States of America. 97: 2241-2246. PMID 10688899 DOI: 10.1073/Pnas.040573397  0.339
2000 Jain V, Mekalanos JJ. Use of lambda phage S and R gene products in an inducible lysis system for Vibrio cholerae- and Salmonella enterica serovar typhimurium-based DNA vaccine delivery systems Infection and Immunity. 68: 986-989. PMID 10639478 DOI: 10.1128/Iai.68.2.986-989.2000  0.367
1999 Chiang SL, Mekalanos JJ, Holden DW. In vivo genetic analysis of bacterial virulence Annual Review of Microbiology. 53: 129-154. PMID 10547688 DOI: 10.1146/Annurev.Micro.53.1.129  0.44
1999 Faruque SM, Rahman MM, Asadulghani, Islam KMN, Mekalanos JJ. Lysogenic conversion of environmental Vibrio mimicus strains by CTXΦ Infection and Immunity. 67: 5723-5729. PMID 10531221 DOI: 10.1128/Iai.67.11.5723-5729.1999  0.421
1999 Lampe DJ, Akerley BJ, Rubin EJ, Mekalanos JJ, Robertson HM. Hyperactive transposase mutants of the Himar1 mariner transposon. Proceedings of the National Academy of Sciences of the United States of America. 96: 11428-33. PMID 10500193 DOI: 10.1073/Pnas.96.20.11428  0.48
1999 Häse CC, Mekalanos JJ. Effects of changes in membrane sodium flux on virulence gene expression in Vibrio cholerae Proceedings of the National Academy of Sciences of the United States of America. 96: 3183-3187. PMID 10077658 DOI: 10.1073/Pnas.96.6.3183  0.426
1999 Fullner KJ, Mekalanos JJ. Genetic characterization of a new type IV-A pilus gene cluster found in both classical and El Tor biotypes of Vibrio cholerae Infection and Immunity. 67: 1393-1404. PMID 10024587 DOI: 10.1128/Iai.67.3.1393-1404.1999  0.43
1999 Rubin EJ, Akerley BJ, Novik VN, Lampe DJ, Husson RN, Mekalanos JJ. In vivo transposition of mariner-based elements in enteric bacteria and mycobacteria. Proceedings of the National Academy of Sciences of the United States of America. 96: 1645-50. PMID 9990078 DOI: 10.1073/Pnas.96.4.1645  0.534
1999 Dziejman M, Kolmar H, Fritz HJ, Mekalanos JJ. ToxR co-operative interactions are not modulated by environmental conditions or periplasmic domain conformation Molecular Microbiology. 31: 305-317. PMID 9987131 DOI: 10.1046/J.1365-2958.1999.01173.X  0.397
1999 Lin W, Fullner KJ, Clayton R, Sexton JA, Rogers MB, Calia KE, Calderwood SB, Fraser C, Mekalanos JJ. Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage. Proceedings of the National Academy of Sciences of the United States of America. 96: 1071-6. PMID 9927695 DOI: 10.1073/Pnas.96.3.1071  0.404
1999 Chiang SL, Mekalanos JJ. rfb Mutations in Vibrio cholerae do not affect surface production of toxin-coregulated pili but still inhibit intestinal colonization Infection and Immunity. 67: 976-980. PMID 9916119 DOI: 10.1128/Iai.67.2.976-980.1999  0.366
1998 Faruque SM, Albert MJ, Mekalanos JJ. Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae Microbiology and Molecular Biology Reviews. 62: 1301-1314. PMID 9841673 DOI: 10.1128/Mmbr.62.4.1301-1314.1998  0.415
1998 Faruque SM, Asadulghani, Saha MN, Alim AR, Albert MJ, Islam KM, Mekalanos JJ. Analysis of clinical and environmental strains of nontoxigenic Vibrio cholerae for susceptibility to CTXPhi: molecular basis for origination of new strains with epidemic potential. Infection and Immunity. 66: 5819-25. PMID 9826360 DOI: 10.1128/Iai.66.12.5819-5825.1998  0.442
1998 Meno Y, Waldor MK, Mekalanos JJ, Amako K. Morphological and physical characterization of the capsular layer of Vibrio cholerae O139 Archives of Microbiology. 170: 339-344. PMID 9818353 DOI: 10.1007/S002030050651  0.348
1998 Klose KE, Novik V, Mekalanos JJ. Identification of multiple σ54-dependent transcriptional activators in vibrio cholerae Journal of Bacteriology. 180: 5256-5259. PMID 9748465 DOI: 10.1128/Jb.180.19.5256-5259.1998  0.485
1998 Rubin EJ, Lin W, Mekalanos JJ, Waldor MK. Replication and integration of a Vibrio cholerae cryptic plasmid linked to the CTX prophage Molecular Microbiology. 28: 1247-1254. PMID 9680213 DOI: 10.1046/J.1365-2958.1998.00889.X  0.537
1998 Faruque SM, Asadulghani, Alim AR, Albert MJ, Islam KM, Mekalanos JJ. Induction of the lysogenic phage encoding cholera toxin in naturally occurring strains of toxigenic Vibrio cholerae O1 and O139. Infection and Immunity. 66: 3752-7. PMID 9673258 DOI: 10.1128/Iai.66.8.3752-3757.1998  0.41
1998 Akerley BJ, Rubin EJ, Camilli A, Lampe DJ, Robertson HM, Mekalanos JJ. Systematic identification of essential genes by in vitro mariner mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 95: 8927-32. PMID 9671781 DOI: 10.1073/Pnas.95.15.8927  0.548
1998 Klose KE, Mekalanos JJ. Distinct roles of an alternative sigma factor during both free-swimming and colonizing phases of the Vibrio cholerae pathogenic cycle Molecular Microbiology. 28: 501-520. PMID 9632254 DOI: 10.1046/J.1365-2958.1998.00809.X  0.788
1998 De Tejada GM, Cotter PA, Heininger U, Camilli A, Akerley BJ, Mekalanos JJ, Miller JF. Neither the Bvg- phase nor the vrg6 locus of Bordetella pertussis is required for respiratory infection in mice Infection and Immunity. 66: 2762-2768. PMID 9596745 DOI: 10.1128/Iai.66.6.2762-2768.1998  0.369
1998 Lee SH, Angelichio MJ, Mekalanos JJ, Camilli A. Nucleotide sequence and spatiotemporal expression of the Vibrio cholerae vieSAB genes during infection Journal of Bacteriology. 180: 2298-2305. PMID 9573178 DOI: 10.1128/Jb.180.9.2298-2305.1998  0.422
1998 Chiang SL, Mekalanos JJ. Use of signature-tagged transposon mutagenesis to identify Vibrio cholerae genes critical for colonization Molecular Microbiology. 27: 797-805. PMID 9515705 DOI: 10.1046/J.1365-2958.1998.00726.X  0.447
1998 Klose KE, Mekalanos JJ. Differential regulation of multiple flagellins in Vibrio cholerae Journal of Bacteriology. 180: 303-316. PMID 9440520 DOI: 10.1128/Jb.180.2.303-316.1998  0.785
1998 Häse CC, Mekalanos JJ. TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae Proceedings of the National Academy of Sciences of the United States of America. 95: 730-734. PMID 9435261 DOI: 10.1073/Pnas.95.2.730  0.49
1998 Acheson DWK, Reidl J, Zhang X, Keusch GT, Mekalanos JJ, Waldor MK. In Vivo Transduction with Shiga Toxin 1-Encoding Phage Infection and Immunity. 66: 4496-4498. DOI: 10.1128/Iai.66.9.4496-4498.1998  0.414
1998 Rubin EJ, Mekalanos JJ, Waldor MK. Mobile genetic elements and the evolution of new epidemic strains of Vibrio cholerae Biomedical Research Reports. 1: 147-161. DOI: 10.1016/S1874-5326(07)80028-7  0.549
1997 Mekalanos JJ, Rubin EJ, Waldor MK. Cholera: Molecular basis for emergence and pathogenesis Fems Immunology and Medical Microbiology. 18: 241-248. PMID 9348159 DOI: 10.1111/J.1574-695X.1997.Tb01052.X  0.427
1997 Waldor MK, Rubin EJ, Pearson GDN, Kimsey H, Mekalanos JJ. Regulation, replication, and integration functions of the Vibrio cholerae CTXφ are encoded by region RS2 Molecular Microbiology. 24: 917-926. PMID 9220000 DOI: 10.1046/J.1365-2958.1997.3911758.X  0.474
1997 Klose KE, Mekalanos JJ. Simultaneous prevention of glutamine synthesis and high-affinity transport attenuates Salmonella typhimurium virulence Infection and Immunity. 65: 587-596. PMID 9009317 DOI: 10.1128/Iai.65.2.587-596.1997  0.772
1996 Mel SF, Mekalanos JJ. Modulation of horizontal gene transfer in pathogenic bacteria by in vivo signals. Cell. 87: 795-8. PMID 8945506 DOI: 10.1016/S0092-8674(00)81986-8  0.448
1996 Slauch JM, Lee AA, Mahan MJ, Mekalanos JJ. Molecular characterization of the oafA locus responsible for acetylation of Salmonella typhimurium O-antigen: OafA is a member of a family of integral membrane trans-acylases Journal of Bacteriology. 178: 5904-5909. PMID 8830685 DOI: 10.1128/Jb.178.20.5904-5909.1996  0.665
1996 Waldor MK, Tschäpe H, Mekalanos JJ. A new type of conjugative transposon encodes resistance to sulfamethoxazole, trimethoprim, and streptomycin in Vibrio cholerae O139 Journal of Bacteriology. 178: 4157-4165. PMID 8763944 DOI: 10.1128/Jb.178.14.4157-4165.1996  0.379
1996 Gardel CL, Mekalanos JJ. Alterations in Vibrio cholerae motility phenotypes correlate with changes in virulence factor expression Infection and Immunity. 64: 2246-2255. PMID 8675334 DOI: 10.1128/Iai.64.6.2246-2255.1996  0.43
1996 Waldor MK, Mekalanos JJ. Lysogenic conversion by a filamentous phage encoding cholera toxin Science. 272: 1910-1913. PMID 8658163 DOI: 10.1126/Science.272.5270.1910  0.444
1996 Reidl J, Mekalanos JJ. Lipoprotein e(P4) is essential for hemin uptake by Haemophilus influenzae Journal of Experimental Medicine. 183: 621-629. PMID 8627173 DOI: 10.1084/Jem.183.2.621  0.395
1996 Ottemann KM, Mekalanos JJ. The ToxR protein of Vibrio cholerae forms homodimers and heterodimers Journal of Bacteriology. 178: 156-162. PMID 8550410 DOI: 10.1128/Jb.178.1.156-162.1996  0.661
1995 Reidl J, Mekalanos JJ. Characterization of Vibrio cholerae bacteriophage K139 and use of a novel mini-transposon to identify a phage-encoded virulence factor Molecular Microbiology. 18: 685-701. PMID 8817491 DOI: 10.1111/J.1365-2958.1995.Mmi_18040685.X  0.394
1995 Camilli A, Mekalanos JJ. Use of recombinase gene fusions to identify Vibrio cholerae genes induced during infection Molecular Microbiology. 18: 671-683. PMID 8817490 DOI: 10.1111/J.1365-2958.1995.Mmi_18040671.X  0.462
1995 Chiang SL, Taylor RK, Koomey M, Mekalanos JJ. Single amino acid substitutions in the N-terminus of Vibrio cholerae TcpA affect: Colonization, autoagglutination, and serum resistance Molecular Microbiology. 17: 1133-1142. PMID 8594332 DOI: 10.1111/J.1365-2958.1995.Mmi_17061133.X  0.4
1995 Mahan MJ, Tobias JW, Slauch JM, Hanna PC, Collier RJ, Mekalanos JJ. Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host. Proceedings of the National Academy of Sciences of the United States of America. 92: 669-73. PMID 7846034 DOI: 10.1073/Pnas.92.3.669  0.755
1995 Ottemann KM, Mekalanos JJ. Analysis of Vibrio cholerae ToxR function by construction of novel fusion proteins Molecular Microbiology. 15: 719-731. PMID 7783643 DOI: 10.1111/J.1365-2958.1995.Tb02380.X  0.665
1995 Killeen KP, Beattie DT, Spriggs DR, Waldor MK, Mekalanos JJ, Coster TS, Kenner JR, Trofa A, Sadoff JC, Taylor DN. Safety, immunogenicity, and efficacy of live attenuated Vibrio cholerae 0139 vaccine prototype The Lancet. 345: 949-952. PMID 7715293 DOI: 10.1016/S0140-6736(95)90698-3  0.33
1995 Slauch JM, Mahan MJ, Michetti P, Neutra MR, Mekalanos JJ. Acetylation (O-factor 5) affects the structural and immunological properties of Salmonella typhimurium lipopolysaccharide O antigen Infection and Immunity. 63: 437-441. PMID 7529745 DOI: 10.1128/Iai.63.2.437-441.1995  0.631
1995 Butterton JR, Beattie DT, Gardel CL, Carroll PA, Hyman T, Killeen KP, Mekalanos JJ, Calderwood SB. Heterologous antigen expression in Vibrio cholerae vector strains. Infection and Immunity. 63: 2689-2696. DOI: 10.1128/Iai.63.7.2689-2696.1995  0.438
1994 Mekalanos JJ. Live attenuated vaccine vectors International Journal of Technology Assessment in Health Care. 10: 131-142. PMID 8157445 DOI: 10.1017/S0266462300014057  0.306
1994 Camilli A, Beattie DT, Mekalanos JJ. Use of genetic recombination as a reporter of gene expression Proceedings of the National Academy of Sciences of the United States of America. 91: 2634-2638. PMID 8146167 DOI: 10.1073/Pnas.91.7.2634  0.41
1994 Slauch JM, Mahan MJ, Mekalanos JJ. In vivo expression technology for selection of bacterial genes specifically induced in host tissues Methods in Enzymology. 235: 481-492. PMID 8057920 DOI: 10.1016/0076-6879(94)35164-3  0.703
1994 Waldor MK, Mekalanos JJ. Emergence of a new cholera pandemic: Molecular analysis of virulence determinants in vibrio cholerae 0139 and development of a live vaccine prototype Journal of Infectious Diseases. 170: 278-283. PMID 8035010 DOI: 10.1093/Infdis/170.2.278  0.422
1994 Slauch JM, Mahan MJ, Mekalanos JJ. Measurement of transcriptional activity in pathogenic bacteria recovered directly from infected host tissue Biotechniques. 16: 641-642+644. PMID 8024783  0.665
1994 Dziejman M, Mekalanos JJ. Analysis of membrane protein interaction: ToxR can dimerize the amino terminus of phage lambda repressor Molecular Microbiology. 13: 485-494. PMID 7997165 DOI: 10.1111/J.1365-2958.1994.Tb00443.X  0.351
1994 Taylor DN, Killeen KP, Hack DC, Kenner JR, Coster TS, Beattie DT, Ezzell J, Hyman T, Trofa A, Sjogren MH, Friedlander A, Mekalanos JJ, Sadoff JC. Development of a live, oral, attenuated vaccine against El Tor cholera Journal of Infectious Diseases. 170: 1518-1523. PMID 7995992 DOI: 10.1093/Infdis/170.6.1518  0.361
1994 Waldor MK, Colwell R, Mekalanos JJ. The Vibrio cholerae O139 serogroup antigen includes an O-antigen capsule and lipopolysaccharide virulence determinants Proceedings of the National Academy of Sciences of the United States of America. 91: 11388-11392. PMID 7972070 DOI: 10.1073/Pnas.91.24.11388  0.309
1994 Michetti P, Porta N, Mahan MJ, Slauch JM, Mekalanos JJ, Blum A, Kraehenbuhl JP, Neutra MR. Monoclonal immunoglobulin a prevents adherence and invasion of polarized epithelial cell monolayers by Salmonella typhimurium Gastroenterology. 107: 915-923. PMID 7926481 DOI: 10.1016/0016-5085(94)90214-3  0.665
1994 Waldor MK, Mekalanos JJ. ToxR regulates virulence gene expression in non-O1 strains of Vibrio cholerae that cause epidemic cholera Infection and Immunity. 62: 72-78. PMID 7903285 DOI: 10.1128/Iai.62.1.72-78.1994  0.364
1994 Mekalanos JJ. Live bacterial vaccines: environmental aspects Current Opinion in Biotechnology. 5: 312-319. PMID 7765009 DOI: 10.1016/0958-1669(94)90035-3  0.341
1993 Lin Z, Kumagai K, Baba K, Mekalanos JJ, Nishibuchi M. Vibrio parahaemolyticus has a homolog of the Vibrio cholerae toxRS operon that mediates environmentally induced regulation of the thermostable direct hemolysin gene Journal of Bacteriology. 175: 3844-3855. PMID 8509337 DOI: 10.1128/Jb.175.12.3844-3855.1993  0.452
1993 Pearson GDN, Woods A, Chiang SL, Mekalanos JJ. CTX genetic element encodes a site-specific recombination system and an intestinal colonization factor Proceedings of the National Academy of Sciences of the United States of America. 90: 3750-3754. PMID 8475125 DOI: 10.1073/Pnas.90.8.3750  0.404
1993 Mahan MJ, Slauch JM, Mekalanos JJ. Selection of bacterial virulence genes that are specifically induced in host tissues Science. 259: 686-688. PMID 8430319 DOI: 10.1126/Science.8430319  0.704
1993 Beattie DT, Mahan MJ, Mekalanos JJ. Repressor binding to a regulatory site in the DNA coding sequence is sufficient to confer transcriptional regulation of the vir-repressed genes (vrg genes) in Bordetella pertussis Journal of Bacteriology. 175: 519-527. PMID 8419298 DOI: 10.1128/Jb.175.2.519-527.1993  0.379
1993 Mahan MJ, Slauch JM, Mekalanos JJ. Bacteriophage P22 transduction of integrated plasmids: Single-step cloning of Salmonella typhimurium gene fusions Journal of Bacteriology. 175: 7086-7091. PMID 8226650 DOI: 10.1128/Jb.175.21.7086-7091.1993  0.642
1993 Mahan MJ, Slauch JM, Hanna PC, Camilli A, Tobias JW, Waldor MK, Mekalanos JJ. Selection for bacterial genes that are specifically induced in host tissues: The hunt for virulence factors Infectious Agents and Disease. 2: 263-268. PMID 8173806  0.67
1992 Miller JF, Johnson SA, Black WJ, Beattie DT, Mekalanos JJ, Falkow S. Constitutive sensory transduction mutations in the Bordetella pertussis bvgS gene. Journal of Bacteriology. 174: 970-9. PMID 1732230 DOI: 10.1128/Jb.174.3.970-979.1992  0.549
1992 Mekalanos JJ. Environmental signals controlling expression of virulence determinants in bacteria Journal of Bacteriology. 174: 1-7. PMID 1729202 DOI: 10.1128/Jb.174.1.1-7.1992  0.312
1992 Parsot C, Mekalanos JJ. Structural analysis of the acfA and acfD genes of Vibrio cholerae: Effects of DNA topology and transcriptional activators on expression Journal of Bacteriology. 174: 5211-5218. PMID 1644747 DOI: 10.1128/Jb.174.16.5211-5218.1992  0.411
1992 Killeen KP, Escuyer V, Mekalanos JJ, Collier RJ. Reversion of recombinant toxoids: mutations in diphtheria toxin that partially compensate for active-site deletions. Proceedings of the National Academy of Sciences of the United States of America. 89: 6207-9. PMID 1631110 DOI: 10.1073/Pnas.89.13.6207  0.477
1992 Ottemann KM, DiRita VJ, Mekalanos JJ. ToxR proteins with substitutions in residues conserved with OmpR fail to activate transcription from the cholera toxin promoter Journal of Bacteriology. 174: 6807-6814. PMID 1400230 DOI: 10.1128/Jb.174.21.6807-6814.1992  0.761
1992 Michetti P, Mahan MJ, Slauch JM, Mekalanos JJ, Neutra MR. Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium Infection and Immunity. 60: 1786-1792. PMID 1373399 DOI: 10.1128/Iai.60.5.1786-1792.1992  0.644
1991 DiRita VJ, Parsot C, Jander G, Mekalanos JJ. Regulatory cascade controls virulence in Vibrio cholerae Proceedings of the National Academy of Sciences of the United States of America. 88: 5403-5407. PMID 2052618 DOI: 10.1073/Pnas.88.12.5403  0.676
1991 Parsot C, Taxman E, Mekalanos JJ. ToxR regulates the production of lipoproteins and the expression of serum resistance in Vibrio cholerae Proceedings of the National Academy of Sciences of the United States of America. 88: 1641-1645. PMID 2000374 DOI: 10.1073/Pnas.88.5.1641  0.476
1991 Parsot C, Mekalanos JJ. Expression of the Vibrio cholerae gene encoding aldehyde dehydrogenase is under control of toxR, the cholera toxin transcriptional activator Journal of Bacteriology. 173: 2842-2851. PMID 1902210 DOI: 10.1128/Jb.173.9.2842-2851.1991  0.481
1991 DiRita VJ, Mekalanos JJ. Periplasmic interaction between two membrane regulatory proteins, ToxR and ToxS, results in signal transduction and transcriptional activation Cell. 64: 29-37. PMID 1898871 DOI: 10.1016/0092-8674(91)90206-E  0.631
1991 Neutra M, Weltzin R, Winner L, Mack J, Michetti P, Morrison L, Fields BN, Mekalanos JJ, Kraehenbuhl JP. Identification and use of protective monoclonal IgA antibodies against viral and bacterial pathogens. Advances in Experimental Medicine and Biology. 310: 179-82. PMID 1808995 DOI: 10.1007/978-1-4615-3838-7_22  0.347
1991 Beattie DT, Shahin R, Mekalanos JJ. A vir-repressed gene of Bordetella pertussis is required for virulence Infection and Immunity. 60: 571-577. PMID 1730491 DOI: 10.1128/Iai.60.2.571-577.1992  0.451
1991 Hall RH, Losonsky G, Silveira AP, Taylor RK, Mekalanos JJ, Witham ND, Levine MM. Immunogenicity of Vibrio cholerae O1 toxin-coregulated pili in experimental and clinical cholera. Infection and Immunity. 59: 2508-12. PMID 1711017 DOI: 10.1128/Iai.59.7.2508-2512.1991  0.678
1991 Winner L, Mack J, Weltzin R, Mekalanos JJ, Kraehenbuhl JP, Neutra MR. New model for analysis of mucosal immunity: Intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection Infection and Immunity. 59: 977-982. PMID 1705246 DOI: 10.1128/Iai.59.3.977-982.1991  0.318
1991 Finn TM, Shahin R, Mekalanos JJ. Characterization of vir-activated TnphoA gene fusions in Bordetella pertussis Infection and Immunity. 59: 3273-3279. PMID 1652562 DOI: 10.1128/Iai.59.9.3273-3279.1991  0.437
1990 Manoil C, Mekalanos JJ, Beckwith J. Alkaline phosphatase fusions: Sensors of subcellular location Journal of Bacteriology. 172: 515-518. PMID 2404939 DOI: 10.1128/Jb.172.2.515-518.1990  0.339
1990 Lee CK, Roberts AL, Finn TM, Knapp S, Mekalanos JJ. A new assay for invasion of HeLa 229 cells by Bordetella pertussis: Effects of inhibitors, phenotypic modulation, and genetic alterations Infection and Immunity. 58: 2516-2522. PMID 2370104 DOI: 10.1128/Iai.58.8.2516-2522.1990  0.415
1990 Miller SI, Mekalanos JJ. Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within microphages Journal of Bacteriology. 172: 2485-2490. PMID 2185222 DOI: 10.1128/Jb.172.5.2485-2490.1990  0.438
1990 Beattie DT, Knapp S, Mekalanos JJ. Evidence that modulation requires sequences downstream of the promoters of two vir-repressed genes of Bordetella pertussis Journal of Bacteriology. 172: 6997-7004. PMID 2174866 DOI: 10.1128/Jb.172.12.6997-7004.1990  0.403
1990 Miller SI, Pulkkinen WS, Selsted ME, Mekalanos JJ. Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium Infection and Immunity. 58: 3706-3710. PMID 2172166 DOI: 10.1128/Iai.58.11.3706-3710.1990  0.407
1990 Soltis MT, Mekalanos JJ, Betley MJ. Identification of a bacteriophage containing a silent staphylococcal variant enterotoxin gene (sezA+) Infection and Immunity. 58: 1614-1619. PMID 2140340 DOI: 10.1128/Iai.58.6.1614-1619.1990  0.363
1990 Parsot C, Mekalanos JJ. Expression of ToxR, the transcriptional activator of the virulence factors in Vibrio cholerae, is modulated by the heat shock response Proceedings of the National Academy of Sciences of the United States of America. 87: 9898-9902. PMID 2124707 DOI: 10.1073/Pnas.87.24.9898  0.411
1990 Pearson GDN, DiRita VJ, Goldberg MB, Boyko SA, Calderwood SB, Mekalanos JJ. New attenuated derivatives of Vibrio cholerae Research in Microbiology. 141: 893-899. PMID 2101479 DOI: 10.1016/0923-2508(90)90127-C  0.553
1990 Sun D, Mekalanos JJ, Taylor RK. Antibodies directed against the toxin-coregulated pilus isolated from vibrio cholerae provide protection in the infant mouse experimental cholera model Journal of Infectious Diseases. 161: 1231-1236. PMID 1971653 DOI: 10.1093/Infdis/161.6.1231  0.402
1989 Miller SI, Mekalanos JJ. Strategies for the development of vaccines for typhoid fever, shigellosis, and cholera Annals of the New York Academy of Sciences. 569: 145-154. PMID 2698084 DOI: 10.1111/J.1749-6632.1989.Tb27365.X  0.344
1989 DiRita VJ, Mekalanos JJ. Genetic regulation of bacterial virulence Annual Review of Genetics. 23: 455-482. PMID 2694940 DOI: 10.1146/Annurev.Ge.23.120189.002323  0.59
1989 Miller VL, DiRita VJ, Mekalanos JJ. Identification of toxS, a regulatory gene whose product enhances ToxR-mediated activation of the cholera toxin promoter Journal of Bacteriology. 171: 1288-1293. PMID 2646275 DOI: 10.1128/Jb.171.3.1288-1293.1989  0.682
1989 Miller SI, Kukral AM, Mekalanos JJ. A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence Proceedings of the National Academy of Sciences of the United States of America. 86: 5054-5058. PMID 2544889 DOI: 10.1073/Pnas.86.13.5054  0.452
1989 Taylor RK, Manoil C, Mekalanos JJ. Broad-host-range vectors for delivery of TnphoA: Use in genetic analysis of secreted virulence determinants of Vibrio cholerae Journal of Bacteriology. 171: 1870-1878. PMID 2539354 DOI: 10.1128/Jb.171.4.1870-1878.1989  0.726
1989 Miller JF, Mekalanos JJ, Falkow S. Coordinate regulation and sensory transduction in the control of bacterial virulence. Science (New York, N.Y.). 243: 916-22. PMID 2537530 DOI: 10.1126/Science.2537530  0.579
1988 Hovde CJ, Calderwood SB, Mekalanos JJ, Collier RJ. Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin I. Proceedings of the National Academy of Sciences of the United States of America. 85: 2568-72. PMID 3357883 DOI: 10.1073/Pnas.85.8.2568  0.537
1988 Betley MJ, Mekalanos JJ. Nucleotide sequence of the type A staphylococcal enterotoxin gene Journal of Bacteriology. 170: 34-41. PMID 3335483 DOI: 10.1128/Jb.170.1.34-41.1988  0.371
1988 Mekalanos JJ. Production and purification of cholera toxin Methods in Enzymology. 165: 169-175. PMID 3231099 DOI: 10.1016/S0076-6879(88)65027-0  0.332
1988 Mekalanos JJ, Peterson KM, Finn T, Knapp S. The pathogenesis and immunology of Vibrio cholerae and Bordetella pertussis. Antonie Van Leeuwenhoek. 54: 379-87. PMID 2904796 DOI: 10.1007/Bf00461855  0.613
1988 Hall RH, Vial PA, Kaper JB, Mekalanos JJ, Levine MM. Morphological studies on fimbriae expressed by Vibrio cholerae 01 Microbial Pathogenesis. 4: 257-265. PMID 2904642 DOI: 10.1016/0882-4010(88)90086-1  0.375
1988 Knapp S, Mekalanos JJ. Two trans-acting regulatory genes (vir and mod) control antigenic modulation in Bordetella pertussis Journal of Bacteriology. 170: 5059-5066. PMID 2903140 DOI: 10.1128/Jb.170.11.5059-5066.1988  0.424
1988 Herrington DA, Hall RH, Losonsky G, Mekalanos JJ, Taylor RK, Levine MM. Toxin, toxin-coregulated pili, and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans. The Journal of Experimental Medicine. 168: 1487-92. PMID 2902187 DOI: 10.1084/Jem.168.4.1487  0.468
1988 Peterson KM, Mekalanos JJ. Characterization of the Vibrio cholerae ToxR regulon: identification of novel genes involved in intestinal colonization. Infection and Immunity. 56: 2822-9. PMID 2902009 DOI: 10.1128/Iai.56.11.2822-2829.1988  0.696
1988 Taylor R, Shaw C, Peterson K, Spears P, Mekalanos J. Safe, live Vibrio cholerae vaccines? Vaccine. 6: 151-154. PMID 2898843 DOI: 10.1016/S0264-410X(88)80019-7  0.67
1988 Miller VL, Mekalanos JJ. A novel suicide vector and its use in construction of insertion mutations: Osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR Journal of Bacteriology. 170: 2575-2583. PMID 2836362 DOI: 10.1128/Jb.170.6.2575-2583.1988  0.406
1988 Calderwood SB, Mekalanos JJ. Confirmation of the Fur operator site by insertion of a synthetic oligonucleotide into an operon fusion plasmid Journal of Bacteriology. 170: 1015-1017. PMID 2828307 DOI: 10.1128/Jb.170.2.1015-1017.1988  0.33
1988 Pierce NF, Cray WC, Kaper JB, Mekalanos JJ. Determinants of immunogenicity and mechanisms of protection by virulent and mutant Vibrio cholerae O1 in rabbits Infection and Immunity. 56: 142-148. PMID 2447017 DOI: 10.1128/Iai.56.1.142-148.1988  0.448
1987 Pierce NF, Kaper JB, Mekalanos JJ, Cray WC, Richardson K. Determinants of the immunogenicity of live virulent and mutant Vibrio cholerae O1 in rabbit intestine Infection and Immunity. 55: 477-481. PMID 3804447 DOI: 10.1128/Iai.55.2.477-481.1987  0.385
1987 Miller VL, Taylor RK, Mekalanos JJ. Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein Cell. 48: 271-279. PMID 3802195 DOI: 10.1016/0092-8674(87)90430-2  0.66
1987 Calderwood SB, Mekalanos JJ. Iron regulation of Shiga-like toxin expression of Escherichia coli is mediated by the fur locus Journal of Bacteriology. 169: 4759-4764. PMID 3308853 DOI: 10.1128/Jb.169.10.4759-4764.1987  0.386
1987 Calderwood SB, Auclair F, Donohue-Rolfe A, Keusch GT, Mekalanos JJ. Nucleotide sequence of the Shiga-like toxin genes of Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 84: 4364-4368. PMID 3299365 DOI: 10.1073/Pnas.84.13.4364  0.37
1987 Taylor RK, Miller VL, Furlong DB, Mekalanos JJ. Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin Proceedings of the National Academy of Sciences of the United States of America. 84: 2833-2837. PMID 2883655 DOI: 10.1073/Pnas.84.9.2833  0.72
1987 Chopra AK, Houston CW, Peterson JW, Prasad R, Mekalanos JJ. Cloning and expression of the Salmonella enterotoxin gene Journal of Bacteriology. 169: 5095-5100. PMID 2822664 DOI: 10.1128/Jb.169.11.5095-5100.1987  0.421
1987 Chopra AK, Houston CW, Peterson JW, Mekalanos JJ. Chromosomal DNA contains the gene coding for Salmonella enterotoxin Fems Microbiology Letters. 43: 345-349. DOI: 10.1111/J.1574-6968.1987.Tb02170.X  0.359
1986 Goldberg I, Mekalanos JJ. Effect of a recA mutation on cholera toxin gene amplification and deletion events Journal of Bacteriology. 165: 723-731. PMID 3949714 DOI: 10.1128/Jb.165.3.723-731.1986  0.438
1986 Goldberg I, Mekalanos JJ. Cloning of the Vibrio cholerae recA gene and construction of a Vibrio cholerae recA mutant Journal of Bacteriology. 165: 715-722. PMID 3005236 DOI: 10.1128/Jb.165.3.715-722.1986  0.441
1985 Pierce NF, Kaper JB, Mekalanos JJ, Cray WC. Role of cholera toxin in enteric colonization by Vibrio cholerae O1 in rabbits Infection and Immunity. 50: 813-816. PMID 4066032 DOI: 10.1128/Iai.50.3.813-816.1985  0.357
1985 Mekalanos JJ. Cholera toxin: genetic analysis, regulation, and role in pathogenesis Current Topics in Microbiology and Immunology. 118: 97-118. PMID 3902383 DOI: 10.1007/978-3-642-70586-1_6  0.407
1985 Betley MJ, Mekalanos JJ. Staphylococcal enterotoxin A is encoded by phage Science. 229: 185-187. PMID 3160112 DOI: 10.1126/Science.3160112  0.418
1985 Miller VL, Mekalanos JJ. Genetic analysis of the cholera toxin-positive regulatory gene toxR Journal of Bacteriology. 163: 580-585. PMID 2991197 DOI: 10.1128/Jb.163.2.580-585.1985  0.428
1984 Sporecke I, Castro D, Mekalanos JJ. Genetic mapping of Vibrio cholerae enterotoxin structural genes Journal of Bacteriology. 157: 253-261. PMID 6690422 DOI: 10.1128/Jb.157.1.253-261.1984  0.417
1984 Miller VL, Mekalanos JJ. Synthesis of cholera toxin is positively regulated at the transcriptional level by toxR Proceedings of the National Academy of Sciences of the United States of America. 81: 3471-3475. PMID 6374658 DOI: 10.1073/Pnas.81.11.3471  0.474
1983 Mekalanos JJ. Duplication and amplification of toxin genes in Vibrio cholerae Cell. 35: 253-263. PMID 6627396 DOI: 10.1016/0092-8674(83)90228-3  0.37
1982 Gregory D, Pearson N, Mekalanos JJ. Molecular cloning of Vibrio cholerae enterotoxin genes in Escherichia coli K-12 Proceedings of the National Academy of Sciences of the United States of America. 79: 2976-2980. PMID 7045877 DOI: 10.1073/Pnas.79.9.2976  0.449
1982 Mekalanos JJ, Moseley SL, Murphy JR, Falkow S. Isolation of enterotoxin structural gene deletion mutations in Vibrio cholerae induced by two mutagenic vibriophages Proceedings of the National Academy of Sciences of the United States of America. 79: 151-155. PMID 6948297 DOI: 10.1073/Pnas.79.1.151  0.608
1980 Mekalanos JJ, Murphy JR. Regulation of cholera toxin production in Vibrio cholerae: Genetic analysis of phenotypic instability in hypertoxinogenic mutants Journal of Bacteriology. 141: 570-576. PMID 7364714 DOI: 10.1128/Jb.141.2.570-576.1980  0.326
1979 Mekalanos JJ, Sublett RD, Romig WR. Genetic mapping of toxin regulatory mutations in Vibrio cholerae Journal of Bacteriology. 139: 859-865. PMID 479110 DOI: 10.1128/Jb.139.3.859-865.1979  0.399
1978 Mekalanos JJ, Collier RJ, Romig WR. Purification of cholera toxin and its subunits: new methods of preparation and the use of hypertoxinogenic mutants Infection and Immunity. 20: 552-558. PMID 669812 DOI: 10.1128/Iai.20.2.552-558.1978  0.469
1978 Mekalanos JJ, Collier RJ, Romig WR. Affinity filters, a new approach to the isolation of tox mutants of Vibrio cholerae Proceedings of the National Academy of Sciences of the United States of America. 75: 941-945. PMID 345281 DOI: 10.1073/Pnas.75.2.941  0.491
1977 Mekalanos JJ, Collier RJ, Romig WR. Simple method for purifying choleragenoid, the natural toxoid of Vibrio cholerae Infection and Immunity. 16: 789-795. PMID 892899 DOI: 10.1128/Iai.16.3.789-795.1977  0.482
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