| Year |
Citation |
Score |
| 2022 |
Pepi MJ, Chacko S, Marqus GM, Singh V, Wang Z, Planck K, Cullinane RT, Meka PN, Gollapalli DR, Ioerger TR, Rhee KY, Cuny GD, Boshoff HIM, Hedstrom L. A d-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of . Acs Infectious Diseases. PMID 35015509 DOI: 10.1021/acsinfecdis.1c00461 |
0.321 |
|
| 2020 |
Lee S, Ku A, Rao Vippila M, Wang Y, Zhang M, Wang X, Hedstrom L, Cuny GD. Mycophenolic anilides as broad specificity inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors. Bioorganic & Medicinal Chemistry Letters. 127543. PMID 32931912 DOI: 10.1016/J.Bmcl.2020.127543 |
0.407 |
|
| 2020 |
Rosenberg MM, Yao T, Patton GC, Redfield AG, Roberts MF, Hedstrom L. Enzyme-substrate-cofactor dynamical networks revealed by high resolution field cycling relaxometry. Biochemistry. PMID 32479091 DOI: 10.1021/Acs.Biochem.0C00212 |
0.392 |
|
| 2020 |
Gupta M, Close DM, Cooper CJ, Wang X, Chirania P, Ossyra JR, Giannone RJ, Engle NL, Tschaplinski TJ, Smith JC, Hedstrom L, Parks JM, Michener JK. Understanding the Structural and Dynamic Changes that Relieve Inhibition of Impdh upon Horizontal Transfer of a Pathway for Coumarate Catabolism in E. coli Biophysical Journal. 118: 504a. DOI: 10.1016/J.Bpj.2019.11.2781 |
0.309 |
|
| 2019 |
Freedman R, Yu R, Sarkis AW, Hedstrom L. A structural determinant of mycophenolic acid resistance in eukaryotic inosine 5'-monophosphate dehydrogenases. Protein Science : a Publication of the Protein Society. PMID 31675145 DOI: 10.1002/Pro.3766 |
0.382 |
|
| 2019 |
Pawlowic MC, Somepalli M, Sateriale A, Herbert GT, Gibson AR, Cuny GD, Hedstrom L, Striepen B. Genetic ablation of purine salvage in reveals nucleotide uptake from the host cell. Proceedings of the National Academy of Sciences of the United States of America. PMID 31570573 DOI: 10.1073/Pnas.1908239116 |
0.371 |
|
| 2019 |
Close DM, Cooper CJ, Wang X, Chirania P, Gupta M, Ossyra JR, Giannone RJ, Engle N, Tschaplinski TJ, Smith JC, Hedstrom L, Parks JM, Michener JK. Horizontal transfer of a pathway for coumarate catabolism unexpectedly inhibits purine nucleotide biosynthesis. Molecular Microbiology. PMID 31532038 DOI: 10.1111/Mmi.14393 |
0.356 |
|
| 2019 |
Yu R, Kim Y, Maltseva N, Braunstein P, Joachimiak A, Hedstrom L. Oxanosine monophosphate is a covalent inhibitor of inosine 5'-monophosphate dehydrogenase. Chemical Research in Toxicology. PMID 30746940 DOI: 10.1021/Acs.Chemrestox.8B00342 |
0.377 |
|
| 2018 |
Long MJC, Lawson AP, Baggio R, Qian Y, Rozhansky L, Fasci D, El Oualid F, Weerapana E, Hedstrom L. Diarylcarbonates are a new class of deubiquitinating enzyme inhibitor. Bioorganic & Medicinal Chemistry Letters. PMID 30528168 DOI: 10.1016/J.Bmcl.2018.11.055 |
0.34 |
|
| 2018 |
Kaushansky A, Hedstrom L, Goldman A, Singh J, Yang PL, Rathod PK, Cynamon M, Wodarz D, Mahadevan D, Tomaras A, Navia MA, Schiffer CA. A call to arms: Unifying the fight against resistance. Science Signaling. 11. PMID 30352947 DOI: 10.1126/Scisignal.Aav0442 |
0.547 |
|
| 2018 |
Chacko S, Boshoff HIM, Singh V, Ferraris DM, Gollapalli DR, Zhang M, Lawson AP, Pepi MJ, Joachimiak A, Rizzi M, Mizrahi V, Cuny GD, Hedstrom L. Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents. Journal of Medicinal Chemistry. PMID 29746130 DOI: 10.1021/Acs.Jmedchem.7B01839 |
0.319 |
|
| 2018 |
Reytor González ML, Alonso-Del-Rivero Antigua M, Hedstrom L, Kuzmič P, Pires JR. Sabellastarte magnifica Carboxypetidase Inhibitor: the first Kunitz inhibitor simultaneously interacting with carboxypeptidases and serine proteases. Biochimie. PMID 29730302 DOI: 10.1016/J.Biochi.2018.04.024 |
0.399 |
|
| 2018 |
Rosenberg MM, Redfield AG, Roberts M, Hedstrom L. Dynamic characteristics of GMP reductase complexes revealed by high resolutionP field cycling NMR relaxometry. Biochemistry. PMID 29547266 DOI: 10.1021/Acs.Biochem.8B00142 |
0.363 |
|
| 2017 |
Lawson AP, Bak DW, Shannon DA, Long MJC, Vijaykumar T, Yu R, Oualid FE, Weerapana E, Hedstrom L. Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry. Oncotarget. 8: 51296-51316. PMID 28881649 DOI: 10.18632/Oncotarget.17261 |
0.31 |
|
| 2017 |
Krishnan B, Hedstrom L, Hebert DN, Gierasch LM, Gershenson A. Expression and Purification of Active Recombinant Human Alpha-1 Antitrypsin (AAT) from Escherichia coli. Methods in Molecular Biology (Clifton, N.J.). 1639: 195-209. PMID 28752459 DOI: 10.1007/978-1-4939-7163-3_19 |
0.312 |
|
| 2017 |
Gorla SK, Zhang Y, Rabideau MM, Qin A, Chacko S, House AL, Johnson CR, Mandapati K, Bernstein HM, McKenney ES, Boshoff H, Zhang M, Glomski IJ, Goldberg JB, Cuny GD, ... ... Hedstrom L, et al. Benzoxazoles, phthalazinones, and arylurea-based compounds with IMPDH-independent antibacterial activity against Francisella tularensis. Antimicrobial Agents and Chemotherapy. PMID 28739786 DOI: 10.1128/Aac.00939-17 |
0.327 |
|
| 2017 |
Zhang S, Burns-Huang KE, Janssen GV, Li H, Ovaa H, Hedstrom L, Darwin KH. Mycobacterium tuberculosis Proteasome Accessory Factor A (PafA) Can Transfer Prokaryotic Ubiquitin-Like Protein (Pup) between Substrates. Mbio. 8. PMID 28223451 DOI: 10.1128/Mbio.00122-17 |
0.333 |
|
| 2016 |
Rosenberg MM, Redfield AG, Roberts MF, Hedstrom L. Substrate and Cofactor Dynamics on Guanosine Monophosphate Reductase Probed by High Resolution Field Cycling 31P NMR Relaxometry. The Journal of Biological Chemistry. PMID 27613871 DOI: 10.1074/Jbc.M116.739516 |
0.343 |
|
| 2016 |
Wei Y, Kuzmic P, Yu R, Modi G, Hedstrom L. Inhibition of IMPDH from Bacillus anthracis: Mechanism revealed by pre-steady state kinetics. Biochemistry. PMID 27541177 DOI: 10.1021/Acs.Biochem.6B00265 |
0.411 |
|
| 2016 |
Coffey RT, Shi Y, Long MJ, Marr MT, Hedstrom L. Ubiquilin Mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling. The Journal of Biological Chemistry. PMID 26740621 DOI: 10.1074/Jbc.M115.691584 |
0.305 |
|
| 2015 |
Lawson AP, Long MJ, Coffey RT, Qian Y, Weerapana E, El Oualid F, Hedstrom L. Naturally occurring isothiocyanates exert anticancer effects by inhibiting deubiquitinating enzymes. Cancer Research. PMID 26542215 DOI: 10.1158/0008-5472.Can-15-1544 |
0.379 |
|
| 2015 |
Makowska-Grzyska M, Kim Y, Gorla SK, Wei Y, Mandapati K, Zhang M, Maltseva N, Modi G, Boshoff HI, Gu M, Aldrich C, Cuny GD, Hedstrom L, Joachimiak A. Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds. Plos One. 10: e0138976. PMID 26440283 DOI: 10.1371/Journal.Pone.0138976 |
0.348 |
|
| 2015 |
Kim Y, Makowska-Grzyska M, Gorla SK, Gollapalli DR, Cuny GD, Joachimiak A, Hedstrom L. Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity. Acta Crystallographica. Section F, Structural Biology Communications. 71: 531-8. PMID 25945705 DOI: 10.1107/S2053230X15000187 |
0.349 |
|
| 2015 |
Makowska-Grzyska M, Kim Y, Maltseva N, Osipiuk J, Gu M, Zhang M, Mandapati K, Gollapalli DR, Gorla SK, Hedstrom L, Joachimiak A. A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity. The Journal of Biological Chemistry. 290: 5893-911. PMID 25572472 DOI: 10.1074/Jbc.M114.619767 |
0.415 |
|
| 2014 |
Mandapati K, Gorla SK, House AL, McKenney ES, Zhang M, Rao SN, Gollapalli DR, Mann BJ, Goldberg JB, Cuny GD, Glomski IJ, Hedstrom L. Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents. Acs Medicinal Chemistry Letters. 5: 846-50. PMID 25147601 DOI: 10.1021/Ml500203P |
0.319 |
|
| 2014 |
Wang J, Han X, Wong CC, Cheng H, Aslanian A, Xu T, Leavis P, Roder H, Hedstrom L, Yates JR, Kashina A. Arginyltransferase ATE1 catalyzes midchain arginylation of proteins at side chain carboxylates in vivo. Chemistry & Biology. 21: 331-7. PMID 24529990 DOI: 10.1016/J.Chembiol.2013.12.017 |
0.338 |
|
| 2013 |
Gorla SK, Kavitha M, Zhang M, Chin JE, Liu X, Striepen B, Makowska-Grzyska M, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. Journal of Medicinal Chemistry. 56: 4028-43. PMID 23668331 DOI: 10.1021/Jm400241J |
0.358 |
|
| 2013 |
Johnson CR, Gorla SK, Kavitha M, Zhang M, Liu X, Striepen B, Mead JR, Cuny GD, Hedstrom L. Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum. Bioorganic & Medicinal Chemistry Letters. 23: 1004-7. PMID 23324406 DOI: 10.1016/J.Bmcl.2012.12.037 |
0.342 |
|
| 2012 |
Gorla SK, Kavitha M, Zhang M, Liu X, Sharling L, Gollapalli DR, Striepen B, Hedstrom L, Cuny GD. Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. Journal of Medicinal Chemistry. 55: 7759-71. PMID 22950983 DOI: 10.1021/Jm3007917 |
0.332 |
|
| 2012 |
Makowska-Grzyska M, Kim Y, Wu R, Wilton R, Gollapalli DR, Wang XK, Zhang R, Jedrzejczak R, Mack JC, Maltseva N, Mulligan R, Binkowski TA, Gornicki P, Kuhn ML, Anderson WF, ... Hedstrom L, et al. Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes. Biochemistry. 51: 6148-63. PMID 22788966 DOI: 10.1021/Bi300511W |
0.433 |
|
| 2012 |
Long MJ, Gollapalli DR, Hedstrom L. Inhibitor mediated protein degradation. Chemistry & Biology. 19: 629-37. PMID 22633414 DOI: 10.1016/J.Chembiol.2012.04.008 |
0.361 |
|
| 2012 |
Hedstrom L. The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (β/α)(8) barrel enzymes. Critical Reviews in Biochemistry and Molecular Biology. 47: 250-63. PMID 22332716 DOI: 10.3109/10409238.2012.656843 |
0.4 |
|
| 2012 |
Kirubakaran S, Gorla SK, Sharling L, Zhang M, Liu X, Ray SS, Macpherson IS, Striepen B, Hedstrom L, Cuny GD. Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH. Bioorganic & Medicinal Chemistry Letters. 22: 1985-8. PMID 22310229 DOI: 10.1016/J.Bmcl.2012.01.029 |
0.331 |
|
| 2012 |
McGrew DA, Hedstrom L. Towards a pathological mechanism for IMPDH1-linked retinitis pigmentosa. Advances in Experimental Medicine and Biology. 723: 539-45. PMID 22183375 DOI: 10.1007/978-1-4614-0631-0_68 |
0.764 |
|
| 2012 |
Hansen BG, Sun XE, Genee HJ, Kaas CS, Nielsen JB, Mortensen UH, Frisvad JC, Hedstrom L. Adaptive evolution of drug targets in producer and non-producer organisms. The Biochemical Journal. 441: 219-26. PMID 21916847 DOI: 10.1042/Bj20111278 |
0.316 |
|
| 2011 |
Patton GC, Stenmark P, Gollapalli DR, Sevastik R, Kursula P, Flodin S, Schuler H, Swales CT, Eklund H, Himo F, Nordlund P, Hedstrom L. Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes. Nature Chemical Biology. 7: 950-8. PMID 22037469 DOI: 10.1038/Nchembio.693 |
0.407 |
|
| 2011 |
Sun XE, Hansen BG, Hedstrom L. Kinetically controlled drug resistance: how Penicillium brevicompactum survives mycophenolic acid. The Journal of Biological Chemistry. 286: 40595-600. PMID 21979957 DOI: 10.1074/Jbc.M111.305235 |
0.37 |
|
| 2011 |
Riera TV, Zheng L, Josephine HR, Min D, Yang W, Hedstrom L. Allosteric activation via kinetic control: potassium accelerates a conformational change in IMP dehydrogenase. Biochemistry. 50: 8508-18. PMID 21870820 DOI: 10.1021/Bi200785S |
0.729 |
|
| 2011 |
Hedstrom L, Liechti G, Goldberg JB, Gollapalli DR. The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors Current Medicinal Chemistry. 18: 1909-1918. PMID 21517780 DOI: 10.2174/092986711795590129 |
0.347 |
|
| 2011 |
Hoefler BC, Gollapalli DR, Hedstrom L. Specific biotinylation of IMP dehydrogenase. Bioorganic & Medicinal Chemistry Letters. 21: 1363-5. PMID 21295473 DOI: 10.1016/J.Bmcl.2011.01.042 |
0.769 |
|
| 2010 |
Josephine HR, Ravichandran KR, Hedstrom L. The Cys319 loop modulates the transition between dehydrogenase and hydrolase conformations in inosine 5'-monophosphate dehydrogenase. Biochemistry. 49: 10674-81. PMID 21062060 DOI: 10.1021/Bi101590C |
0.447 |
|
| 2010 |
Gollapalli DR, Macpherson IS, Liechti G, Gorla SK, Goldberg JB, Hedstrom L. Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases. Chemistry & Biology. 17: 1084-91. PMID 21035731 DOI: 10.1016/J.Chembiol.2010.07.014 |
0.387 |
|
| 2010 |
Mansfield BE, Oltean HN, Oliver BG, Hoot SJ, Leyde SE, Hedstrom L, White TC. Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi. Plos Pathogens. 6: e1001126. PMID 20941354 DOI: 10.1371/Journal.Ppat.1001126 |
0.601 |
|
| 2010 |
Spellicy CJ, Xu D, Cobb G, Hedstrom L, Bowne SJ, Sullivan LS, Daiger SP. Investigating the mechanism of disease in the RP10 form of retinitis pigmentosa. Advances in Experimental Medicine and Biology. 664: 541-8. PMID 20238057 DOI: 10.1007/978-1-4419-1399-9_62 |
0.409 |
|
| 2010 |
Sun XE, Sharling L, Muthalagi M, Mudeppa DG, Pankiewicz KW, Felczak K, Rathod PK, Mead J, Striepen B, Hedstrom L. Prodrug activation by Cryptosporidium thymidine kinase. The Journal of Biological Chemistry. 285: 15916-22. PMID 20231284 DOI: 10.1074/Jbc.M110.101543 |
0.631 |
|
| 2010 |
Macpherson IS, Kirubakaran S, Gorla SK, Riera TV, D'Aquino JA, Zhang M, Cuny GD, Hedstrom L. The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity. Journal of the American Chemical Society. 132: 1230-1. PMID 20052976 DOI: 10.1021/Ja909947A |
0.724 |
|
| 2009 |
Maurya SK, Gollapalli DR, Kirubakaran S, Zhang M, Johnson CR, Benjamin NN, Hedstrom L, Cuny GD. Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. Journal of Medicinal Chemistry. 52: 4623-30. PMID 19624136 DOI: 10.1021/Jm900410U |
0.351 |
|
| 2009 |
Hedstrom L. IMP dehydrogenase: structure, mechanism, and inhibition. Chemical Reviews. 109: 2903-28. PMID 19480389 DOI: 10.1021/Cr900021W |
0.434 |
|
| 2008 |
Mortimer SE, Xu D, McGrew D, Hamaguchi N, Lim HC, Bowne SJ, Daiger SP, Hedstrom L. IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA. The Journal of Biological Chemistry. 283: 36354-60. PMID 18974094 DOI: 10.1074/Jbc.M806143200 |
0.752 |
|
| 2008 |
Min D, Josephine HR, Li H, Lakner C, MacPherson IS, Naylor GJ, Swofford D, Hedstrom L, Yang W. An enzymatic atavist revealed in dual pathways for water activation. Plos Biology. 6: e206. PMID 18752347 DOI: 10.1371/Journal.Pbio.0060206 |
0.394 |
|
| 2008 |
Riera TV, Wang W, Josephine HR, Hedstrom L. A kinetic alignment of orthologous inosine-5'-monophosphate dehydrogenases. Biochemistry. 47: 8689-96. PMID 18642884 DOI: 10.1021/Bi800674A |
0.762 |
|
| 2008 |
Hedstrom L. IMP dehydrogenase-linked retinitis pigmentosa. Nucleosides, Nucleotides & Nucleic Acids. 27: 839-49. PMID 18600550 DOI: 10.1080/15257770802146486 |
0.393 |
|
| 2008 |
Xu D, Cobb G, Spellicy CJ, Bowne SJ, Daiger SP, Hedstrom L. Retinal isoforms of inosine 5'-monophosphate dehydrogenase type 1 are poor nucleic acid binding proteins. Archives of Biochemistry and Biophysics. 472: 100-4. PMID 18295591 DOI: 10.1016/J.Abb.2008.02.012 |
0.503 |
|
| 2008 |
Umejiego NN, Gollapalli D, Sharling L, Volftsun A, Lu J, Benjamin NN, Stroupe AH, Riera TV, Striepen B, Hedstrom L. Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosis. Chemistry & Biology. 15: 70-7. PMID 18215774 DOI: 10.1016/J.Chembiol.2007.12.010 |
0.72 |
|
| 2008 |
Umejiego NN, Gollapalli D, Sharling L, Volftsun A, Lu J, Benjamin NN, Stroupe AH, Riera TV, Striepen B, Hedstrom L. Targeting a Prokaryotic Protein in a Eukaryotic Pathogen: Identification of Lead Compounds against Cryptosporidiosis (DOI:10.1016/j.chembiol.2007.12.010) Chemistry and Biology. 15: 200. DOI: 10.1016/j.chembiol.2008.02.007 |
0.659 |
|
| 2007 |
Liu L, Mushero N, Hedstrom L, Gershenson A. Short-lived protease serpin complexes: partial disruption of the rat trypsin active site. Protein Science : a Publication of the Protein Society. 16: 2403-11. PMID 17962402 DOI: 10.1110/Ps.073111207 |
0.362 |
|
| 2007 |
Chen L, Gao G, Felczak K, Bonnac L, Patterson SE, Wilson D, Bennett EM, Jayaram HN, Hedstrom L, Pankiewicz KW. Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues. Journal of Medicinal Chemistry. 50: 5743-51. PMID 17958343 DOI: 10.1021/Jm070568J |
0.309 |
|
| 2007 |
Gladysheva IP, Sazonova IY, Houng A, Hedstrom L, Reed GL. Regulation of nonproteolytic active site formation in plasminogen. Biochemistry. 46: 8879-87. PMID 17616171 DOI: 10.1021/Bi602591G |
0.318 |
|
| 2006 |
Liu L, Mushero N, Hedstrom L, Gershenson A. Conformational distributions of protease-serpin complexes: a partially translocated complex. Biochemistry. 45: 10865-72. PMID 16953572 DOI: 10.1021/Bi0609568 |
0.349 |
|
| 2006 |
Hedstrom L, Gan L. IMP dehydrogenase: structural schizophrenia and an unusual base. Current Opinion in Chemical Biology. 10: 520-5. PMID 16919497 DOI: 10.1016/J.Cbpa.2006.08.005 |
0.382 |
|
| 2006 |
Rejman D, Olesiak M, Chen L, Patterson SE, Wilson D, Jayaram HN, Hedstrom L, Pankiewicz KW. Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase. Journal of Medicinal Chemistry. 49: 5018-22. PMID 16884314 DOI: 10.1021/Jm060479R |
0.321 |
|
| 2006 |
Bowne SJ, Sullivan LS, Mortimer SE, Hedstrom L, Zhu J, Spellicy CJ, Gire AI, Hughbanks-Wheaton D, Birch DG, Lewis RA, Heckenlively JR, Daiger SP. Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis. Investigative Ophthalmology & Visual Science. 47: 34-42. PMID 16384941 DOI: 10.1167/Iovs.05-0868 |
0.789 |
|
| 2005 |
Guillén Schlippe YV, Hedstrom L. Guanidine derivatives rescue the Arg418Ala mutation of Tritrichomonas foetus IMP dehydrogenase. Biochemistry. 44: 16695-700. PMID 16342959 DOI: 10.1021/Bi051603W |
0.796 |
|
| 2005 |
Guillén Schlippe YV, Hedstrom L. Is Arg418 the catalytic base required for the hydrolysis step of the IMP dehydrogenase reaction? Biochemistry. 44: 11700-7. PMID 16128570 DOI: 10.1021/Bi048342V |
0.8 |
|
| 2005 |
Mortimer SE, Hedstrom L. Autosomal dominant retinitis pigmentosa mutations in inosine 5'-monophosphate dehydrogenase type I disrupt nucleic acid binding. The Biochemical Journal. 390: 41-7. PMID 15882147 DOI: 10.1042/Bj20042051 |
0.79 |
|
| 2005 |
Köhler GA, Gong X, Bentink S, Theiss S, Pagani GM, Agabian N, Hedstrom L. The functional basis of mycophenolic acid resistance in Candida albicans IMP dehydrogenase. The Journal of Biological Chemistry. 280: 11295-302. PMID 15665003 DOI: 10.1074/Jbc.M409847200 |
0.459 |
|
| 2005 |
Guillén Schlippe YV, Hedstrom L. A twisted base? The role of arginine in enzyme-catalyzed proton abstractions. Archives of Biochemistry and Biophysics. 433: 266-78. PMID 15581582 DOI: 10.1016/J.Abb.2004.09.018 |
0.788 |
|
| 2004 |
Umejiego NN, Li C, Riera T, Hedstrom L, Striepen B. Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design. The Journal of Biological Chemistry. 279: 40320-7. PMID 15269207 DOI: 10.1074/Jbc.M407121200 |
0.755 |
|
| 2004 |
Zhang Y, Heinsen MH, Kostic M, Pagani GM, Riera TV, Perovic I, Hedstrom L, Snider BB, Pochapsky TC. Analogs of 1-phosphonooxy-2,2-dihydroxy-3-oxo-5-(methylthio)pentane, an acyclic intermediate in the methionine salvage pathway: a new preparation and characterization of activity with E1 enolase/phosphatase from Klebsiella oxytoca. Bioorganic & Medicinal Chemistry. 12: 3847-55. PMID 15210152 DOI: 10.1016/J.Bmc.2004.05.002 |
0.731 |
|
| 2004 |
Guillén Schlippe YV, Riera TV, Seyedsayamdost MR, Hedstrom L. Substitution of the conserved Arg-Tyr dyad selectively disrupts the hydrolysis phase of the IMP dehydrogenase reaction. Biochemistry. 43: 4511-21. PMID 15078097 DOI: 10.1021/Bi035823Q |
0.786 |
|
| 2004 |
Striepen B, Pruijssers AJ, Huang J, Li C, Gubbels MJ, Umejiego NN, Hedstrom L, Kissinger JC. Gene transfer in the evolution of parasite nucleotide biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 101: 3154-9. PMID 14973196 DOI: 10.1073/Pnas.0304686101 |
0.349 |
|
| 2004 |
McLean JE, Hamaguchi N, Belenky P, Mortimer SE, Stanton M, Hedstrom L. Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo. The Biochemical Journal. 379: 243-51. PMID 14766016 DOI: 10.1042/Bj20031585 |
0.789 |
|
| 2003 |
Hedstrom L, Gan L, Schlippe YG, Riera T, Seyedsayamdost M. IMP dehydrogenase: the dynamics of drug selectivity. Nucleic Acids Research. Supplement (2001). 97-8. PMID 14510398 DOI: 10.1093/nass/3.1.97 |
0.743 |
|
| 2003 |
Sivaraman S, Zwahlen J, Bell AF, Hedstrom L, Tonge PJ. Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs. Biochemistry. 42: 4406-13. PMID 12693936 DOI: 10.1021/Bi0300229 |
0.441 |
|
| 2003 |
Gan L, Seyedsayamdost MR, Shuto S, Matsuda A, Petsko GA, Hedstrom L. The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase. Biochemistry. 42: 857-63. PMID 12549902 DOI: 10.1021/Bi0271401 |
0.411 |
|
| 2002 |
Hedstrom L. An overview of serine proteases. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 21.10. PMID 18429229 DOI: 10.1002/0471140864.Ps2110S26 |
0.313 |
|
| 2002 |
Hedstrom L. Serine protease mechanism and specificity. Chemical Reviews. 102: 4501-24. PMID 12475199 DOI: 10.1021/Cr000033X |
0.314 |
|
| 2002 |
Gan L, Petsko GA, Hedstrom L. Crystal structure of a ternary complex of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: NAD+ orients the active site loop for catalysis. Biochemistry. 41: 13309-17. PMID 12403633 DOI: 10.1021/Bi0203785 |
0.437 |
|
| 2001 |
Huang X, Knoell CT, Frey G, Hazegh-Azam M, Tashjian AH, Hedstrom L, Abeles RH, Timasheff SN. Modulation of recombinant human prostate-specific antigen: activation by Hofmeister salts and inhibition by azapeptides. Appendix: thermodynamic interpretation of the activation by concentrated salts. Biochemistry. 40: 11734-41. PMID 11570874 DOI: 10.1021/Bi010364J |
0.75 |
|
| 2001 |
Pasternak A, White A, Jeffery CJ, Medina N, Cahoon M, Ringe D, Hedstrom L. The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity. Protein Science : a Publication of the Protein Society. 10: 1331-42. PMID 11420435 DOI: 10.1110/Ps.44101 |
0.439 |
|
| 2001 |
McLean JE, Neidhardt EA, Grossman TH, Hedstrom L. Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase. Biochemistry. 40: 2194-200. PMID 11329288 DOI: 10.1021/Bi001810Q |
0.626 |
|
| 2001 |
Sazonova IY, Houng AK, Chowdhry SA, Robinson BR, Hedstrom L, Reed GL. The mechanism of a bacterial plasminogen activator intermediate between streptokinase and staphylokinase. The Journal of Biological Chemistry. 276: 12609-13. PMID 11278483 DOI: 10.1074/Jbc.M009265200 |
0.328 |
|
| 2000 |
Hedstrom L, Frey PA. Robert H. Abeles (1926-2000). Nature. 407: 854. PMID 11057653 DOI: 10.1038/35038202 |
0.447 |
|
| 2000 |
Kerr KM, Digits JA, Kuperwasser N, Hedstrom L. Asp338 controls hydride transfer in Escherichia coli IMP dehydrogenase. Biochemistry. 39: 9804-10. PMID 10933797 DOI: 10.1021/Bi0005409 |
0.79 |
|
| 2000 |
Wang S, Reed GL, Hedstrom L. Zymogen activation in the streptokinase-plasminogen complex. Ile1 is required for the formation of a functional active site. European Journal of Biochemistry / Febs. 267: 3994-4001. PMID 10866798 DOI: 10.1046/J.1432-1327.2000.01434.X |
0.423 |
|
| 2000 |
Dai Y, Hedstrom L, Abeles RH. Inactivation of cysteine proteases by (acyloxy)methyl ketones using S'-P' interactions. Biochemistry. 39: 6498-502. PMID 10828965 DOI: 10.1021/Bi0002378 |
0.578 |
|
| 2000 |
McMillan FM, Cahoon M, White A, Hedstrom L, Petsko GA, Ringe D. Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6. Biochemistry. 39: 4533-42. PMID 10758003 DOI: 10.1021/Bi992645L |
0.422 |
|
| 2000 |
Kerr KM, Cahoon M, Bosco DA, Hedstrom L. Monovalent cation activation in Escherichia coli inosine 5'-monophosphate dehydrogenase. Archives of Biochemistry and Biophysics. 375: 131-7. PMID 10683258 DOI: 10.1006/Abbi.1999.1644 |
0.389 |
|
| 2000 |
Digits JA, Hedstrom L. Drug selectivity is determined by coupling across the NAD+ site of IMP dehydrogenase. Biochemistry. 39: 1771-7. PMID 10677226 DOI: 10.1021/Bi992288E |
0.802 |
|
| 1999 |
Neidhardt EA, Punreddy SR, McLean JE, Hedstrom L, Grossman TH. Expression and characterization of E. coli-produced soluble, functional human dihydroorotate dehydrogenase: a potential target for immunosuppression. Journal of Molecular Microbiology and Biotechnology. 1: 183-8. PMID 10941801 |
0.591 |
|
| 1999 |
Digits JA, Hedstrom L. Species-specific inhibition of inosine 5'-monophosphate dehydrogenase by mycophenolic acid. Biochemistry. 38: 15388-97. PMID 10563825 DOI: 10.1021/Bi991558Q |
0.824 |
|
| 1999 |
Reed GL, Houng AK, Liu L, Parhami-Seren B, Matsueda LH, Wang S, Hedstrom L. A catalytic switch and the conversion of streptokinase to a fibrin-targeted plasminogen activator. Proceedings of the National Academy of Sciences of the United States of America. 96: 8879-83. PMID 10430864 DOI: 10.1073/Pnas.96.16.8879 |
0.381 |
|
| 1999 |
Hedstrom L. IMP dehydrogenase: Mechanism of action and inhibition Current Medicinal Chemistry. 6: 545-560. PMID 10390600 |
0.361 |
|
| 1999 |
Wang S, Reed GL, Hedstrom L. Deletion of Ile1 changes the mechanism of streptokinase: evidence for the molecular sexuality hypothesis. Biochemistry. 38: 5232-40. PMID 10213631 DOI: 10.1021/Bi981915H |
0.359 |
|
| 1999 |
Digits JA, Hedstrom L. Kinetic mechanism of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase. Biochemistry. 38: 2295-306. PMID 10029522 DOI: 10.1021/Bi982305K |
0.809 |
|
| 1998 |
Pasternak A, Liu X, Lin TY, Hedstrom L. Activating a zymogen without proteolytic processing: Mutation of Lys15 and Asn194 activates trypsinogen Biochemistry. 37: 16201-16210. PMID 9819212 DOI: 10.1021/Bi980951D |
0.435 |
|
| 1998 |
Hung SH, Hedstrom L. Converting trypsin to elastase: Substitution of the S1 site and adjacent loops reconstitutes esterase specificity but not amidase activity Protein Engineering. 11: 669-673. PMID 9749919 DOI: 10.1093/Protein/11.8.669 |
0.455 |
|
| 1998 |
Wang W, Hedstrom L. A potent 'fat base' nucleotide inhibitor of IMP dehydrogenase Biochemistry. 37: 11949-11952. PMID 9718319 DOI: 10.1021/Bi981132W |
0.425 |
|
| 1998 |
Kurth T, Grahn S, Thormann M, Ullmann D, Hofmann HJ, Jakubke HD, Hedstrom L. Engineering the S1' subsite of trypsin: Design of a protease which cleaves between dibasic residues Biochemistry. 37: 11434-11440. PMID 9708978 DOI: 10.1021/Bi980842Z |
0.347 |
|
| 1997 |
Kerr KM, Hedstrom L. The roles of conserved carboxylate residues in IMP dehydrogenase and identification of a transition state analog. Biochemistry. 36: 13365-73. PMID 9341229 DOI: 10.1021/Bi9714161 |
0.463 |
|
| 1997 |
Kurth T, Ullmann D, Jakubke HD, Hedstrom L. Converting trypsin to chymotrypsin: Structural determinants of S1' specificity Biochemistry. 36: 10098-10104. PMID 9254605 DOI: 10.1021/Bi970937L |
0.357 |
|
| 1997 |
Wang W, Hedstrom L. Kinetic mechanism of human inosine 5'-monophosphate dehydrogenase type II: Random addition of substrates and ordered release of products Biochemistry. 36: 8479-8483. PMID 9214292 DOI: 10.1021/Bi970226N |
0.414 |
|
| 1997 |
Farazi T, Leichman J, Harris T, Cahoon M, Hedstrom L. Isolation and characterization of mycophenolic acid-resistant mutants of inosine-5'-monophosphate dehydrogenase Journal of Biological Chemistry. 272: 961-965. PMID 8995388 DOI: 10.1074/Jbc.272.2.961 |
0.365 |
|
| 1996 |
Venekei I, Hedstrom L, Rutter WJ. A rapid and effective procedure for screening protease mutants. Protein Engineering. 9: 85-93. PMID 9053907 DOI: 10.1093/Protein/9.1.85 |
0.354 |
|
| 1996 |
Hedstrom L. Trypsin: A case study in the structural determinants of enzyme specificity Biological Chemistry. 377: 465-470. PMID 8922280 |
0.34 |
|
| 1996 |
Hedstrom L, Lin TY, Fast W. Hydrophobic interactions control zymogen activation in the trypsin family of serine proteases Biochemistry. 35: 4515-4523. PMID 8605201 DOI: 10.1021/Bi951928K |
0.419 |
|
| 1996 |
Wang W, Papov VV, Minakawa N, Matsuda A, Biemann K, Hedstrom L. Inactivation of inosine 5'-monophosphate dehydrogenase by the antiviral agent 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide 5'-monophosphate. Biochemistry. 35: 95-101. PMID 8555204 DOI: 10.1021/Bi951499Q |
0.458 |
|
| 1995 |
Perona JJ, Hedstrom L, Rutter WJ, Fletterick RJ. Structural origins of substrate discrimination in trypsin and chymotrypsin. Biochemistry. 34: 1489-99. PMID 7849008 DOI: 10.1021/Bi00005A004 |
0.412 |
|
| 1994 |
Perona JJ, Hedstrom L, Wagner RL, Rutter WJ, Craik CS, Fletterick RJ. Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser. Biochemistry. 33: 3252-9. PMID 8136360 DOI: 10.1021/Bi00177A016 |
0.438 |
|
| 1994 |
Hedstrom L, Farr-Jones S, Kettner CA, Rutter WJ. Converting trypsin to chymotrypsin: ground-state binding does not determine substrate specificity. Biochemistry. 33: 8764-9. PMID 8038166 DOI: 10.1021/Bi00195A018 |
0.347 |
|
| 1994 |
Hedstrom L, Perona JJ, Rutter WJ. Converting trypsin to chymotrypsin: residue 172 is a substrate specificity determinant. Biochemistry. 33: 8757-63. PMID 8038165 DOI: 10.1021/Bi00195A017 |
0.434 |
|
| 1994 |
Hedstrom L. Engineering for redesign Current Opinion in Structural Biology. 4: 608-611. DOI: 10.1016/S0959-440X(94)90225-9 |
0.373 |
|
| 1993 |
Schellenberger V, Turck CW, Hedstrom L, Rutter WJ. Mapping the S' subsites of serine proteases using acyl transfer to mixtures of peptide nucleophiles. Biochemistry. 32: 4349-53. PMID 8476865 DOI: 10.1021/Bi00067A026 |
0.363 |
|
| 1991 |
Hedstrom L, Graf L, Stewart CB, Rutter WJ, Phillips MA. Modulation of enzyme specificity by site-directed mutagenesis. Methods in Enzymology. 202: 671-87. PMID 1784193 DOI: 10.1016/0076-6879(91)02031-4 |
0.444 |
|
| 1990 |
Hedstrom L, Wang CC. Mycophenolic acid and thiazole adenine dinucleotide inhibition of tritrichomonas foetus inosine 5′-monophosphate dehydrogenase: Implications on enzyme mechanism Biochemistry. 29: 849-854. PMID 1971185 |
0.371 |
|
| 1988 |
Hedstrom L, Abeles R. 3-Deoxy-D-manno-octulosonate-8-phosphate synthase catalyzes the C-O bond cleavage of phosphoenolpyruvate Biochemical and Biophysical Research Communications. 157: 816-820. PMID 2904815 DOI: 10.1016/S0006-291X(88)80322-X |
0.578 |
|
| 1987 |
Verham R, Meek TD, Hedstrom L, Wang CC. Purification, characterization, and kinetic analysis of inosine 5′-monophosphate dehydrogenase of Tritrichomonas foetus Molecular and Biochemical Parasitology. 24: 1-12. PMID 2886911 DOI: 10.1016/0166-6851(87)90110-1 |
0.399 |
|
| 1984 |
Hedstrom L, Moorman AR, Dobbs J, Abeles RH. Suicide inactivation of chymotrypsin by benzoxazinones. Biochemistry. 23: 1753-9. PMID 6562904 DOI: 10.1021/Bi00303A026 |
0.606 |
|
| 1983 |
Anton DL, Hedstrom L, Fish SM, Abeles RH. Mechanism of enolpyruvyl shikimate-3-phosphate synthase exchange of phosphoenolpyruvate with solvent protons Biochemistry. 22: 5903-5908. DOI: 10.1021/Bi00294A033 |
0.559 |
|
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