| Year |
Citation |
Score |
| 2023 |
Kaur H, Minchella P, Alvarez-Carbonell D, Purandare N, Nagampalli VK, Blankenberg D, Hulgan T, Gerschenson M, Karn J, Aras S, Kallianpur AR. Contemporary Antiretroviral Therapy Dysregulates Iron Transport and Augments Mitochondrial Dysfunction in HIV-Infected Human Microglia and Neural-Lineage Cells. International Journal of Molecular Sciences. 24. PMID 37569616 DOI: 10.3390/ijms241512242 |
0.378 |
|
| 2023 |
Sanders-Beer BE, Archin NM, Brumme ZL, Busch M, Deleage C, O'Doherty U, Hughes SH, Jerome K, Jones RB, Karn J, Kearney MF, Keele B, Kulpa D, Laird G, Li JZ, et al. Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary. Aids Research and Human Retroviruses. PMID 37126090 DOI: 10.1089/AID.2022.0188 |
0.514 |
|
| 2023 |
Rheinberger M, Costa AL, Kampmann M, Glavas D, Shytaj IL, Sreeram S, Penzo C, Tibroni N, Garcia-Mesa Y, Leskov K, Fackler OT, Vlahovicek K, Karn J, Lucic B, Herrmann C, et al. Genomic profiling of HIV-1 integration in microglia cells links viral integration to the topologically associated domains. Cell Reports. 42: 112110. PMID 36790927 DOI: 10.1016/j.celrep.2023.112110 |
0.587 |
|
| 2022 |
Mbonye U, Kizito F, Karn J. New insights into transcription elongation control of HIV-1 latency and rebound. Trends in Immunology. PMID 36503686 DOI: 10.1016/j.it.2022.11.003 |
0.616 |
|
| 2022 |
Wietgrefe SW, Duan L, Anderson J, Marqués G, Sanders M, Cummins NW, Badley AD, Dobrowolski C, Karn J, Pagliuzza A, Chomont N, Sannier G, Dubé M, Kaufmann DE, Zuck P, et al. Detecting Sources of Immune Activation and Viral Rebound in HIV Infection. Journal of Virology. e0088522. PMID 35856674 DOI: 10.1128/jvi.00885-22 |
0.531 |
|
| 2022 |
Sreeram S, Ye F, Garcia-Mesa Y, Nguyen K, El Sayed A, Leskov K, Karn J. The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder. Trends in Immunology. PMID 35840529 DOI: 10.1016/j.it.2022.06.003 |
0.584 |
|
| 2022 |
Ye F, Alvarez-Carbonell D, Nguyen K, Leskov K, Garcia-Mesa Y, Sreeram S, Valadkhan S, Karn J. Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells. Plos Pathogens. 18: e1010110. PMID 35797416 DOI: 10.1371/journal.ppat.1010110 |
0.627 |
|
| 2022 |
Scully EP, Aga E, Tsibris A, Archin N, Starr K, Ma Q, Morse GD, Squires KE, Howell BJ, Wu G, Hosey L, Sieg S, Ehui L, Giguel F, Coxen K, ... ... Karn J, et al. Impact of Tamoxifen on Vorinostat-Induced HIV Expression in Women on Antiretroviral Therapy (ACTG A5366:The MOXIE trial). Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 35176755 DOI: 10.1093/cid/ciac136 |
0.445 |
|
| 2022 |
Miller JS, Davis ZB, Helgeson E, Reilly C, Thorkelson A, Anderson J, Lima NS, Jorstad S, Hart GT, Lee JH, Safrit JT, Wong H, Cooley S, Gharu L, Chung H, ... ... Karn J, et al. Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial. Nature Medicine. PMID 35102335 DOI: 10.1038/s41591-021-01651-9 |
0.467 |
|
| 2022 |
Joussef-Piña S, Nankya I, Nalukwago S, Baseke J, Rwambuya S, Winner D, Kyeyune F, Chervenak K, Thiel B, Asaad R, Dobrowolski C, Luttge B, Lawley B, Kityo CM, Boom WH, ... Karn J, et al. Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda. Retrovirology. 19: 1. PMID 35033105 DOI: 10.1186/s12977-022-00587-3 |
0.533 |
|
| 2022 |
Shukla M, Kizito F, Mbonye U, Nguyen K, Dobrowolski C, Karn J. A Reliable Primary Cell Model for HIV Latency: The QUECEL (Quiescent Effector Cell Latency) Method. Methods in Molecular Biology (Clifton, N.J.). 2407: 57-68. PMID 34985657 DOI: 10.1007/978-1-0716-1871-4_5 |
0.402 |
|
| 2021 |
Nguyen K, Dobrowolski C, Shukla M, Cho WK, Luttge B, Karn J. Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation. Plos Pathogens. 17: e1010014. PMID 34673825 DOI: 10.1371/journal.ppat.1010014 |
0.582 |
|
| 2021 |
Gianella S, Rawlings SA, Nakazawa M, Chaillon A, Strain M, Layman L, Caballero G, Scully E, Scott B, Pacis C, Weber KM, Landay A, Anderson C, Karn J. Sex differences in HIV Persistence and Reservoir Size during Aging. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 34612493 DOI: 10.1093/cid/ciab873 |
0.501 |
|
| 2021 |
Mbonye U, Leskov K, Shukla M, Valadkhan S, Karn J. Biogenesis of P-TEFb in CD4+ T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways. Plos Pathogens. 17: e1009581. PMID 34529720 DOI: 10.1371/journal.ppat.1009581 |
0.513 |
|
| 2021 |
McMahon DK, Zheng L, Cyktor JC, Aga E, Macatangay BJ, Godfrey C, Para M, Mitsuyasu RT, Hesselgesser J, Dragavon J, Dobrowolski C, Karn J, Acosta EP, Gandhi RT, Mellors JW. A Phase 1/2 Randomized, Placebo-Controlled Trial of Romidespin in Persons With HIV-1 on Suppressive Antiretroviral Therapy. The Journal of Infectious Diseases. 224: 648-656. PMID 34398236 DOI: 10.1093/infdis/jiaa777 |
0.541 |
|
| 2021 |
Shytaj IL, Procopio FA, Tarek M, Carlon-Andres I, Tang HY, Goldman AR, Munshi M, Kumar Pal V, Forcato M, Sreeram S, Leskov K, Ye F, Lucic B, Cruz N, Ndhlovu LC, ... ... Karn J, et al. Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress. Embo Molecular Medicine. e13901. PMID 34289240 DOI: 10.15252/emmm.202013901 |
0.439 |
|
| 2020 |
McMahon DK, Zheng L, Cyktor JC, Aga E, Macatangay BJ, Godfrey C, Para M, Mitsuyasu RT, Hesselgesser J, Dragavon J, Dobrowolski C, Karn J, Acosta EP, Gandhi RT, Mellors JW, et al. A phase I/II randomized, placebo-controlled trial of romidepsin in persons with HIV-1 on suppressive antiretroviral therapy to assess safety and activation of HIV-1 expression (A5315). The Journal of Infectious Diseases. PMID 33349862 DOI: 10.1093/infdis/jiaa777 |
0.552 |
|
| 2019 |
Alvarez-Carbonell D, Ye F, Ramanath N, Garcia-Mesa Y, Knapp PE, Hauser KF, Karn J. Cross-talk between microglia and neurons regulates HIV latency. Plos Pathogens. 15: e1008249. PMID 31887215 DOI: 10.1371/Journal.Ppat.1008249 |
0.614 |
|
| 2019 |
Dobrowolski C, Valadkhan S, Graham AC, Shukla M, Ciuffi A, Telenti A, Karn J. Entry of Polarized Effector Cells into Quiescence Forces HIV Latency. Mbio. 10. PMID 30914509 DOI: 10.1128/Mbio.00337-19 |
0.621 |
|
| 2019 |
Karn J, Dobrowolski C, Valadkhan S, Wille P, Hoh R, Ghandi M, Deeks S, Scully E. Hormonal control of HIV-1 latency by estrogen imparts gender-specific restrictions on the latent reservoir Journal of Virus Eradication. 5: 9. DOI: 10.1016/S2055-6640(20)31036-0 |
0.56 |
|
| 2019 |
Dobrowolski C, Karn J, Scully E, Weber KM, Landay AL. Women undergoing reproductive aging show increased reservoir sizes associated with removal of hormonal control of HIV-1 latency by oestrogen Journal of Virus Eradication. 5: 23. DOI: 10.1016/S2055-6640(20)30131-X |
0.472 |
|
| 2019 |
Kizito F, Karn J, Mbonye U, Dobrowolski C, Valadkhan S. Visualisation of HIV reactivation from latency in primary resting memory T-cells Journal of Virus Eradication. 5: 14. DOI: 10.1016/S2055-6640(20)30107-2 |
0.535 |
|
| 2018 |
Shortridge MD, Wille PT, Jones AN, Davidson A, Bogdanovic J, Arts E, Karn J, Robinson JA, Varani G. An ultra-high affinity ligand of HIV-1 TAR reveals the RNA structure recognized by P-TEFb. Nucleic Acids Research. PMID 30481318 DOI: 10.2210/Pdb6D2U/Pdb |
0.469 |
|
| 2018 |
Chen L, Feng Z, Yue H, Bazdar D, Mbonye U, Zender C, Harding CV, Bruggeman L, Karn J, Sieg SF, Wang B, Jin G. Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA. Nature Communications. 9: 4585. PMID 30389917 DOI: 10.1038/S41467-018-07006-2 |
0.643 |
|
| 2018 |
Scully EP, Gandhi M, Johnston R, Hoh R, Lockhart A, Dobrowolski C, Pagliuzza A, Milush JM, Baker CA, Girling V, Ellefson A, Gorelick R, Lifson J, Altfeld M, Alter G, ... ... Karn J, et al. Sex-Based Differences in HIV-1 Reservoir Activity and Residual Immune Activation. The Journal of Infectious Diseases. PMID 30371873 DOI: 10.1093/Infdis/Jiy617 |
0.624 |
|
| 2018 |
Das B, Dobrowolski C, Luttge B, Valadkhan S, Chomont N, Johnston R, Bacchetti P, Hoh R, Gandhi M, Deeks SG, Scully E, Karn J. Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir. Proceedings of the National Academy of Sciences of the United States of America. PMID 30061382 DOI: 10.1073/Pnas.1803468115 |
0.542 |
|
| 2018 |
Alvarez-Carbonell D, Ye F, Ramanath N, Dobrowolski C, Karn J. The Glucocorticoid Receptor Is a Critical Regulator of HIV Latency in Human Microglial Cells. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 29987742 DOI: 10.1007/S11481-018-9798-1 |
0.659 |
|
| 2018 |
Mbonye U, Wang B, Gokulrangan G, Shi W, Yang S, Karn J. Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation. The Journal of Biological Chemistry. PMID 29743242 DOI: 10.1074/Jbc.Ra117.001347 |
0.445 |
|
| 2018 |
Li Z, Mbonye U, Feng Z, Wang X, Gao X, Karn J, Zhou Q. The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency. Plos Pathogens. 14: e1007012. PMID 29684085 DOI: 10.1371/Journal.Ppat.1007012 |
0.665 |
|
| 2017 |
Llewellyn GN, Alvarez-Carbonell D, Chateau M, Karn J, Cannon PM. HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. Journal of Neurovirology. PMID 29256041 DOI: 10.1007/S13365-017-0604-2 |
0.623 |
|
| 2017 |
Mbonye U, Karn J. The Molecular Basis for Human Immunodeficiency Virus Latency. Annual Review of Virology. PMID 28715973 DOI: 10.1146/Annurev-Virology-101416-041646 |
0.609 |
|
| 2017 |
Nguyen K, Das B, Dobrowolski C, Karn J. Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency. Mbio. 8. PMID 28246360 DOI: 10.1128/Mbio.00133-17 |
0.657 |
|
| 2017 |
Alvarez-Carbonell D, Garcia-Mesa Y, Milne S, Das B, Dobrowolski C, Rojas R, Karn J. Toll-like receptor 3 activation selectively reverses HIV latency in microglial cells. Retrovirology. 14: 9. PMID 28166799 DOI: 10.1186/S12977-017-0335-8 |
0.596 |
|
| 2017 |
Checkley M, Luttge B, Dobrowolski C, Karn J. Mobilizing NK cells for an HIV Cure: NK cells can target and kill latently HIV-1-infected primary T cells following proviral reactivation Journal of Virus Eradication. 3: 51. DOI: 10.1016/S2055-6640(20)30672-5 |
0.594 |
|
| 2017 |
Luttge B, Dobrowolski C, Checkley MA, Karn J. Developing an in vitro model for HIV-1 latency in Tfh cells using tonsillar tissue Journal of Virus Eradication. 3: 4. DOI: 10.1016/S2055-6640(20)30580-X |
0.572 |
|
| 2016 |
Garcia-Mesa Y, Jay TR, Checkley MA, Luttge B, Dobrowolski C, Valadkhan S, Landreth GE, Karn J, Alvarez-Carbonell D. Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system. Journal of Neurovirology. PMID 27873219 DOI: 10.1007/S13365-016-0499-3 |
0.611 |
|
| 2016 |
Garrido C, Spivak AM, Soriano-Sarabia N, Checkley MA, Barker E, Karn J, Planelles V, Margolis DM. HIV Latency-Reversing Agents Have Diverse Effects on Natural Killer Cell Function. Frontiers in Immunology. 7: 356. PMID 27708642 DOI: 10.3389/Fimmu.2016.00356 |
0.558 |
|
| 2016 |
Kaminski R, Chen Y, Salkind J, Bella R, Young WB, Ferrante P, Karn J, Malcolm T, Hu W, Khalili K. Negative Feedback Regulation of HIV-1 by Gene Editing Strategy. Scientific Reports. 6: 31527. PMID 27528385 DOI: 10.1038/srep31527 |
0.565 |
|
| 2016 |
Kaminski R, Chen Y, Fischer T, Tedaldi E, Napoli A, Zhang Y, Karn J, Hu W, Khalili K. Corrigendum: Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing. Scientific Reports. 6: 28213. PMID 27389633 DOI: 10.1038/Srep28213 |
0.519 |
|
| 2016 |
Li Q, Karim AF, Ding X, Das B, Dobrowolski C, Gibson RM, Quiñones-Mateu ME, Karn J, Rojas RE. Novel high throughput pooled shRNA screening identifies NQO1 as a potential drug target for host directed therapy for tuberculosis. Scientific Reports. 6: 27566. PMID 27297123 DOI: 10.1038/Srep27566 |
0.301 |
|
| 2016 |
Saxena D, Spino M, Tricta F, Connelly J, Cracchiolo BM, Hanauske AR, D'Alliessi Gandolfi D, Mathews MB, Karn J, Holland B, Park MH, Pe'ery T, Palumbo PE, Hanauske-Abel HM. Drug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory Trial. Plos One. 11: e0154842. PMID 27191165 DOI: 10.1371/Journal.Pone.0154842 |
0.607 |
|
| 2016 |
Ye F, Karn J. Viruses, Mark Thy Message Well. Cell Host & Microbe. 19: 568-70. PMID 27173921 DOI: 10.1016/J.Chom.2016.04.018 |
0.399 |
|
| 2016 |
Kaminski R, Chen Y, Fischer T, Tedaldi E, Napoli A, Zhang Y, Karn J, Hu W, Khalili K. Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing. Scientific Reports. 6: 22555. PMID 26939770 DOI: 10.1016/S2055-6640(20)31337-6 |
0.629 |
|
| 2016 |
Karn J, Das B, Dobrowolski C, Garcia-Mesa Y, Alvarez-Carbonell D, Milne S, Scully E, Deeks S, Gandhi M, Johnston R. A-104 Distinct mechanisms of hormonal control of HIV latency in T-cells and microglial cells Journal of Acquired Immune Deficiency Syndromes. 71: 35. DOI: 10.1097/01.Qai.0000479642.18043.A9 |
0.567 |
|
| 2015 |
Sahu G, Farley K, El-Hage N, Aiamkitsumrit B, Fassnacht R, Kashanchi F, Ochem A, Simon GL, Karn J, Hauser KF, Tyagi M. Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR. Virology. 483: 185-202. PMID 25980739 DOI: 10.1016/J.Virol.2015.03.036 |
0.607 |
|
| 2015 |
Mbonye UR, Wang B, Gokulrangan G, Chance MR, Karn J. Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression. Proteomics. 15: 2078-86. PMID 25900325 DOI: 10.1002/Pmic.201500038 |
0.496 |
|
| 2015 |
Das B, Dobrowolski C, Shahir AM, Feng Z, Yu X, Sha J, Bissada NF, Weinberg A, Karn J, Ye F. Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications. Virology. 474: 65-81. PMID 25463605 DOI: 10.1016/J.Virol.2014.10.033 |
0.591 |
|
| 2015 |
Karn J, Das B, Dobrowolski C, Scully E, Deeks SG, Gandhi M, Johnston RE. Estrogen potently blocks HIV re-emergence from latency and points to gender-specific differences in HIV reservoirs and novel cure strategies Journal of Virus Eradication. 1: 20-21. DOI: 10.1016/S2055-6640(20)31350-9 |
0.626 |
|
| 2015 |
Sahu G, Farley K, El-Hage N, Aiamkitsumrit B, Fassnacht R, Kashanchi F, Ochem A, Simon GL, Karn J, Hauser KF, Tyagi M. Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR Virology. 483: 185-202. DOI: 10.1016/j.virol.2015.03.036 |
0.524 |
|
| 2014 |
Chen Y, Zhang L, Estarás C, Choi SH, Moreno L, Karn J, Moresco JJ, Yates JR, Jones KA. A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation. Genes & Development. 28: 2261-75. PMID 25319827 DOI: 10.1101/Gad.250449.114 |
0.636 |
|
| 2014 |
Hu W, Kaminski R, Yang F, Zhang Y, Cosentino L, Li F, Luo B, Alvarez-Carbonell D, Garcia-Mesa Y, Karn J, Mo X, Khalili K. RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. Proceedings of the National Academy of Sciences of the United States of America. 111: 11461-6. PMID 25049410 DOI: 10.1073/Pnas.1405186111 |
0.615 |
|
| 2014 |
Lucera MB, Tilton CA, Mao H, Dobrowolski C, Tabler CO, Haqqani AA, Karn J, Tilton JC. The histone deacetylase inhibitor vorinostat (SAHA) increases the susceptibility of uninfected CD4+ T cells to HIV by increasing the kinetics and efficiency of postentry viral events. Journal of Virology. 88: 10803-12. PMID 25008921 DOI: 10.1128/Jvi.00320-14 |
0.632 |
|
| 2014 |
Jadlowsky JK, Wong JY, Graham AC, Dobrowolski C, Devor RL, Adams MD, Fujinaga K, Karn J. Negative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat. Molecular and Cellular Biology. 34: 1911-28. PMID 24636995 DOI: 10.1128/Mcb.01013-13 |
0.722 |
|
| 2014 |
Mbonye U, Karn J. Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure. Virology. 454: 328-39. PMID 24565118 DOI: 10.1016/J.Virol.2014.02.008 |
0.603 |
|
| 2013 |
Mbonye UR, Gokulrangan G, Datt M, Dobrowolski C, Cooper M, Chance MR, Karn J. Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes. Plos Pathogens. 9: e1003338. PMID 23658523 DOI: 10.1371/Journal.Ppat.1003338 |
0.464 |
|
| 2013 |
Karn J. A new BET on the control of HIV latency. Cell Cycle (Georgetown, Tex.). 12: 545-6. PMID 23370386 DOI: 10.4161/Cc.23679 |
0.689 |
|
| 2012 |
Wires ES, Alvarez D, Dobrowolski C, Wang Y, Morales M, Karn J, Harvey BK. Methamphetamine activates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and induces human immunodeficiency virus (HIV) transcription in human microglial cells. Journal of Neurovirology. 18: 400-10. PMID 22618514 DOI: 10.1007/S13365-012-0103-4 |
0.668 |
|
| 2012 |
Karn J, Stoltzfus CM. Transcriptional and posttranscriptional regulation of HIV-1 gene expression. Cold Spring Harbor Perspectives in Medicine. 2: a006916. PMID 22355797 DOI: 10.1101/Cshperspect.A006916 |
0.612 |
|
| 2011 |
Mbonye U, Karn J. Control of HIV latency by epigenetic and non-epigenetic mechanisms. Current Hiv Research. 9: 554-67. PMID 22211660 DOI: 10.2174/157016211798998736 |
0.672 |
|
| 2011 |
Kim YK, Mbonye U, Hokello J, Karn J. T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway. Journal of Molecular Biology. 410: 896-916. PMID 21763495 DOI: 10.1016/J.Jmb.2011.03.054 |
0.642 |
|
| 2011 |
Summers MF, Karn J. Special issue: Structural and molecular biology of HIV. Journal of Molecular Biology. 410: 489-90. PMID 21762794 DOI: 10.1016/J.Jmb.2011.05.001 |
0.564 |
|
| 2011 |
Friedman J, Cho WK, Chu CK, Keedy KS, Archin NM, Margolis DM, Karn J. Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2. Journal of Virology. 85: 9078-89. PMID 21715480 DOI: 10.1128/Jvi.00836-11 |
0.644 |
|
| 2011 |
Lalonde MS, Lobritz MA, Ratcliff A, Chamanian M, Athanassiou Z, Tyagi M, Wong J, Robinson JA, Karn J, Varani G, Arts EJ. Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA. Plos Pathogens. 7: e1002038. PMID 21625572 DOI: 10.1371/Journal.Ppat.1002038 |
0.651 |
|
| 2011 |
Karn J. The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit. Current Opinion in Hiv and Aids. 6: 4-11. PMID 21242887 DOI: 10.1097/Coh.0B013E328340Ffbb |
0.661 |
|
| 2010 |
Tyagi M, Pearson RJ, Karn J. Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction. Journal of Virology. 84: 6425-37. PMID 20410271 DOI: 10.1128/Jvi.01519-09 |
0.494 |
|
| 2009 |
Davidson A, Leeper TC, Athanassiou Z, Patora-Komisarska K, Karn J, Robinson JA, Varani G. Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein. Proceedings of the National Academy of Sciences of the United States of America. 106: 11931-6. PMID 19584251 DOI: 10.1073/Pnas.0900629106 |
0.418 |
|
| 2008 |
Pearson R, Kim YK, Hokello J, Lassen K, Friedman J, Tyagi M, Karn J. Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latency. Journal of Virology. 82: 12291-303. PMID 18829756 DOI: 10.1128/Jvi.01383-08 |
0.62 |
|
| 2007 |
Tyagi M, Karn J. CBF-1 promotes transcriptional silencing during the establishment of HIV-1 latency. The Embo Journal. 26: 4985-95. PMID 18007589 DOI: 10.1038/Sj.Emboj.7601928 |
0.674 |
|
| 2006 |
Kim YK, Bourgeois CF, Pearson R, Tyagi M, West MJ, Wong J, Wu SY, Chiang CM, Karn J. Recruitment of TFIIH to the HIV LTR is a rate-limiting step in the emergence of HIV from latency. The Embo Journal. 25: 3596-604. PMID 16874302 DOI: 10.1038/Sj.Emboj.7601248 |
0.674 |
|
| 2002 |
Kim YK, Bourgeois CF, Isel C, Churcher MJ, Karn J. Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation. Molecular and Cellular Biology. 22: 4622-37. PMID 12052871 DOI: 10.1128/Mcb.22.13.4622-4637.2002 |
0.378 |
|
| 2002 |
Bourgeois CF, Kim YK, Churcher MJ, West MJ, Karn J. Spt5 cooperates with human immunodeficiency virus type 1 Tat by preventing premature RNA release at terminator sequences. Molecular and Cellular Biology. 22: 1079-93. PMID 11809800 DOI: 10.1128/MCB.22.4.1079-1093.2002 |
0.393 |
|
| 2001 |
West MJ, Lowe AD, Karn J. Activation of human immunodeficiency virus transcription in T cells revisited: NF-kappaB p65 stimulates transcriptional elongation. Journal of Virology. 75: 8524-37. PMID 11507198 DOI: 10.1128/JVI.75.18.8524-8537.2001 |
0.414 |
|
| 1999 |
Karn J. Tackling Tat Journal of Molecular Biology. 293: 235-254. PMID 10550206 DOI: 10.1006/jmbi.1999.3060 |
0.383 |
|
| 1999 |
Isel C, Karn J. Direct evidence that HIV-1 Tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation Journal of Molecular Biology. 290: 929-941. PMID 10438593 DOI: 10.1006/jmbi.1999.2933 |
0.424 |
|
| 1999 |
West MJ, Karn J. Stimulation of Tat-associated kinase-independent transcriptional elongation from the human immunodeficiency virus type-1 long terminal repeat by a cellular enhancer. The Embo Journal. 18: 1378-86. PMID 10064603 DOI: 10.1093/emboj/18.5.1378 |
0.447 |
|
| 1998 |
Karn J, Keen NJ, Churcher MJ, Aboul-ela F, Varani G, Hamy F, Felder ER, Heizmann G, Klimkait T. The HIV tat-TAR interaction, a novel target for drug discovery Pharmacochemistry Library. 29: 121-132. DOI: 10.1016/S0165-7208(98)80051-2 |
0.441 |
|
| 1997 |
Keen NJ, Churcher MJ, Karn J. Transfer of Tat and release of TAR RNA during the activation of the human immunodeficiency virus type-1 transcription elongation complex Embo Journal. 16: 5260-5272. PMID 9311986 DOI: 10.1093/emboj/16.17.5260 |
0.309 |
|
| 1997 |
Hamy F, Felder ER, Heizmann G, Lazdins J, Aboul-ela F, Varani G, Karn J, Klimkait T. An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication. Proceedings of the National Academy of Sciences of the United States of America. 94: 3548-53. PMID 9108013 DOI: 10.1073/Pnas.94.8.3548 |
0.492 |
|
| 1996 |
Aboul-ela F, Karn J, Varani G. Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge Nucleic Acids Research. 24: 3974-3981. PMID 8918800 DOI: 10.1093/Nar/24.20.3974 |
0.31 |
|
| 1996 |
Mikaélian I, Krieg M, Gait MJ, Karn J. Interactions of INS (CRS) elements and the splicing machinery regulate the production of Rev-responsive mRNAs Journal of Molecular Biology. 257: 246-264. PMID 8609621 DOI: 10.1006/jmbi.1996.0160 |
0.311 |
|
| 1995 |
Rittner K, Churcher MJ, Gait MJ, Karn J. The Human Immunodeficiency Virus Long Terminal Repeat Includes a Specialised Initiator Element which is Required for Tat-responsive Transcription Journal of Molecular Biology. 248: 562-580. PMID 7752225 DOI: 10.1006/jmbi.1995.0243 |
0.507 |
|
| 1995 |
Aboul-ela F, Karn J, Varani G. The Structure of the Human Immunodeficiency Virus Type-1 TAR RNA Reveals Principles of RNA Recognition by Tat Protein Journal of Molecular Biology. 253: 313-332. PMID 7563092 DOI: 10.1006/Jmbi.1995.0555 |
0.332 |
|
| 1995 |
Gait MJ, Karn J. Progress in anti-HIV structure-based drug design Trends in Biotechnology. 13: 430-438. PMID 7546568 DOI: 10.1016/S0167-7799(00)88998-2 |
0.419 |
|
| 1994 |
Mann DA, Mikaélian I, Zemmel RW, Green SM, Lowe AD, Kimura T, Singh M, Butler PJG, Gait MJ, Karn J. A molecular rheostat: Co-operative rev binding to stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression Journal of Molecular Biology. 241: 193-207. PMID 8057359 DOI: 10.1006/JMBI.1994.1488 |
0.308 |
|
| 1993 |
Gait MJ, Karn J. RNA recognition by the human immuno-deficiency virus Tat and Rev proteins Trends in Biochemical Sciences. 18: 255-259. PMID 8212135 DOI: 10.1016/0968-0004(93)90176-N |
0.394 |
|
| 1993 |
Asseline U, Grasby J, Hamy F, Iwai S, Mann DA, Pritchard C, Karn J, Gait MJ. HIV gene regulatory proteins tat and rev and their interactions with synthetic RNA Nucleic Acids Symposium Series. 113-114. PMID 7504239 |
0.361 |
|
| 1992 |
Karn J, Graeble MA. New insights into the mechanism of HIV-1 trans-activation Trends in Genetics. 8: 365-368. PMID 1440870 DOI: 10.1016/0168-9525(92)90284-B |
0.526 |
|
| 1991 |
Karn J, Dingwall C, Finch JT, Heaphy S, Gait MJ. RNA binding by the tat and rev proteins of HIV-1 Biochimie. 73: 9-16. PMID 1903308 DOI: 10.1016/0300-9084(91)90068-C |
0.391 |
|
| 1991 |
Kimura T, Karn J. Murine retrovirus vector expressing env gene of human immunodeficiency virus type 1 (HIV-1) Virus. 41: 85-94. PMID 1810088 |
0.443 |
|
| 1990 |
Dingwall C, Ernberg I, Gait MJ, Green SM, Heaphy S, Karn J, Lowe AD, Singh M, Skinner MA. HIV-1 tat protein stimulates transcription by binding to a U-rich bulge in the stem of the TAR RNA structure Embo Journal. 9: 4145-4153. PMID 2249668 |
0.389 |
|
| 1989 |
Cann AJ, Karn J. Molecular biology of HIV: New insights into the virus life-cycle Aids. 3. PMID 2558687 |
0.444 |
|
| 1989 |
Dingwall C, Ernberg I, Gait MJ, Green SM, Heaphy S, Karn J, Lowe AD, Singh M, Skinner MA, Valerio R. Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro Proceedings of the National Academy of Sciences of the United States of America. 86: 6925-6929. PMID 2476805 DOI: 10.1073/pnas.86.18.6925 |
0.4 |
|
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