| Year |
Citation |
Score |
| 2023 |
Levites Y, Dammer EB, Ran Y, Tsering W, Duong D, Abreha M, Gadhavi J, Lolo K, Trejo-Lopez J, Phillips JL, Iturbe A, Erqiuzi A, Moore BD, Ryu D, Natu A, ... ... Borchelt DR, et al. Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease. Biorxiv : the Preprint Server For Biology. PMID 38076912 DOI: 10.1101/2023.11.29.568318 |
0.369 |
|
| 2023 |
Ayers JI, Xu G, Lu Q, Dillon K, Fromholt S, Borchelt DR. Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice. Viruses. 15. PMID 37766226 DOI: 10.3390/v15091819 |
0.63 |
|
| 2023 |
Williams T, Bathe T, Vo Q, Sacilotto P, McFarland K, Ruiz AJ, Hery GP, Sullivan P, Borchelt DR, Prokop S, Chakrabarty P. Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy. Acta Neuropathologica Communications. 11: 99. PMID 37337279 DOI: 10.1186/s40478-023-01581-2 |
0.378 |
|
| 2022 |
Xu G, Fromholt S, Borchelt DR. Modeling the Competition between Misfolded Aβ Conformers That Produce Distinct Types of Amyloid Pathology in Alzheimer's Disease. Biomolecules. 12. PMID 35883442 DOI: 10.3390/biom12070886 |
0.652 |
|
| 2022 |
Xia Y, Prokop S, Bell BM, Gorion KM, Croft CL, Nasif L, Xu G, Riffe CJ, Manaois AN, Strang KH, Quintin SS, Paterno G, Tansey MG, Borchelt DR, Golde TE, et al. Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice. Communications Biology. 5: 446. PMID 35550593 DOI: 10.1038/s42003-022-03373-1 |
0.667 |
|
| 2022 |
Moore BD, Levites Y, Xu G, Hampton H, Adamo MF, Croft CL, Futch HS, Moran C, Fromholt S, Janus C, Prokop S, Dickson D, Lewis J, Giasson BI, Golde TE, ... Borchelt DR, et al. Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts. Free Neuropathology. 3. PMID 35494163 DOI: 10.17879/freeneuropathology-2022-3766 |
0.675 |
|
| 2022 |
Williams T, Ruiz AJ, Ruiz AM, Vo Q, Tsering W, Xu G, McFarland K, Giasson BI, Sullivan P, Borchelt DR, Chakrabarty P. Impact of APOE genotype on prion-type propagation of tauopathy. Acta Neuropathologica Communications. 10: 57. PMID 35440098 DOI: 10.1186/s40478-022-01359-y |
0.664 |
|
| 2022 |
Xu G, Ulm BS, Howard J, Fromholt SE, Lu Q, Lee BB, Walker A, Borchelt DR, Lewis J. TAPPing into the potential of inducible tau/APP transgenic mice. Neuropathology and Applied Neurobiology. PMID 35067965 DOI: 10.1111/nan.12791 |
0.678 |
|
| 2021 |
Lloyd GM, Dhillon JS, Gorion KM, Riffe C, Fromholt SE, Xia Y, Giasson BI, Borchelt DR. Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model. Molecular Neurodegeneration. 16: 63. PMID 34503546 DOI: 10.1186/s13024-021-00486-9 |
0.329 |
|
| 2021 |
Ayers JI, Xu G, Dillon K, Lu Q, Chen Z, Beckman J, Moreno-Romero AK, Zamora DL, Galaleldeen A, Borchelt DR. Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence. Acta Neuropathologica Communications. 9: 92. PMID 34016165 DOI: 10.1186/s40478-021-01191-w |
0.646 |
|
| 2021 |
Cockey SG, McFarland KN, Koller EJ, Brooks MMT, Gonzalez De La Cruz E, Cruz PE, Ceballos-Diaz C, Rosario AM, Levites YR, Borchelt DR, Golde TE, Giasson BI, Chakrabarty P. Il-10 signaling reduces survival in mouse models of synucleinopathy. Npj Parkinson's Disease. 7: 30. PMID 33741985 DOI: 10.1038/s41531-021-00169-8 |
0.798 |
|
| 2021 |
Ulm BS, Borchelt DR, Moore BD. Remodeling Alzheimer-amyloidosis models by seeding. Molecular Neurodegeneration. 16: 8. PMID 33588898 DOI: 10.1186/s13024-021-00429-4 |
0.355 |
|
| 2021 |
Xia Y, Chen Z, Xu G, Borchelt DR, Ayers JI, Giasson BI. Novel SOD1 monoclonal antibodies against the electrostatic loop preferentially detect misfolded SOD1 aggregates. Neuroscience Letters. 742: 135553. PMID 33346076 DOI: 10.1016/j.neulet.2020.135553 |
0.609 |
|
| 2020 |
Ayers JI, Borchelt DR. Phenotypic diversity in ALS and the role of poly-conformational protein misfolding. Acta Neuropathologica. PMID 32930869 DOI: 10.1007/S00401-020-02222-X |
0.39 |
|
| 2020 |
Zhou Y, Borchelt D, Bauson JC, Fazio S, Miles JR, Tavori H, Notterpek L. Subcellular diversion of cholesterol by gain- and loss-of-function mutations in PMP22. Glia. PMID 32511821 DOI: 10.1002/Glia.23840 |
0.329 |
|
| 2020 |
Xu G, Fromholt SE, Chakrabarty P, Zhu F, Liu X, Pace MC, Koh J, Golde TE, Levites Y, Lewis J, Borchelt DR. Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis. Acta Neuropathologica Communications. 8: 43. PMID 32252825 DOI: 10.1186/S40478-020-00911-Y |
0.706 |
|
| 2020 |
Williams T, Borchelt DR, Chakrabarty P. Therapeutic approaches targeting Apolipoprotein E function in Alzheimer's disease. Molecular Neurodegeneration. 15: 8. PMID 32005122 DOI: 10.1186/S13024-020-0358-9 |
0.353 |
|
| 2020 |
Crown A, McAlary L, Fagerli E, Brown H, Yerbury JJ, Galaleldeen A, Cashman NR, Borchelt DR, Ayers JI. Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection. Plos One. 15: e0227655. PMID 31999698 DOI: 10.1371/Journal.Pone.0227655 |
0.442 |
|
| 2020 |
Koller EJ, Gonzalez De La Cruz E, Weinrich M, Williams T, Cruz PE, Ryu D, Golde TE, Sullivan PM, Lewis J, Borchelt DR, Chakrabarty P. Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy. Molecular Neurobiology. PMID 31903524 DOI: 10.1007/S12035-019-01859-4 |
0.83 |
|
| 2019 |
Dhillon JS, Trejo-Lopez JA, Riffe C, Levites Y, Sacino AN, Borchelt DR, Yachnis AY, Giasson BI. Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils. Acta Neuropathologica Communications. 7: 80. PMID 31109378 DOI: 10.1186/S40478-019-0733-3 |
0.454 |
|
| 2019 |
Zhou Y, Miles JR, Tavori H, Lin M, Khoshbouei H, Borchelt D, Bazick H, Landreth GE, Lee S, Fazio S, Notterpek L. PMP22 regulates cholesterol trafficking and ABCA1-mediated cholesterol efflux. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31061090 DOI: 10.1523/Jneurosci.2942-18.2019 |
0.32 |
|
| 2019 |
Gallego-Iradi MC, Strunk H, Crown AM, Davila R, Brown H, Rodriguez-Lebron E, Borchelt DR. N-terminal sequences in matrin 3 mediate phase separation into droplet-like structures that recruit TDP43 variants lacking RNA binding elements. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 31019288 DOI: 10.1038/S41374-019-0260-7 |
0.333 |
|
| 2019 |
Crown AM, Roberts BL, Crosby K, Brown H, Ayers JI, Hart PJ, Borchelt DR. Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis. G3 (Bethesda, Md.). PMID 30622123 DOI: 10.1534/G3.118.200787 |
0.371 |
|
| 2018 |
Osking Z, Ayers JI, Hildebrandt R, Skruber K, Brown H, Ryu D, Eukovich AR, Golde TE, Borchelt DR, Read TA, Vitriol EA. ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons. Iscience. 11: 294-304. PMID 30639851 DOI: 10.1016/J.Isci.2018.12.026 |
0.353 |
|
| 2018 |
Moloney C, Rayaprolu S, Howard J, Fromholt S, Brown H, Collins M, Cabrera M, Duffy C, Siemienski Z, Miller D, Borchelt DR, Lewis J. Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3. Acta Neuropathologica Communications. 6: 137. PMID 30563574 DOI: 10.1186/S40478-018-0631-0 |
0.426 |
|
| 2018 |
De Rossi P, Andrew RJ, Musial TF, Buggia-Prevot V, Xu G, Ponnusamy M, Ly H, Krause SV, Rice RC, de l'Estoile V, Valin T, Salem S, Despa F, Borchelt DR, Bindokas VP, et al. Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models. Brain Pathology (Zurich, Switzerland). PMID 30506549 DOI: 10.1111/Bpa.12687 |
0.696 |
|
| 2018 |
Crosby K, Crown AM, Roberts BL, Brown H, Ayers JI, Borchelt DR. Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models. Plos One. 13: e0206751. PMID 30399166 DOI: 10.1371/Journal.Pone.0206751 |
0.351 |
|
| 2018 |
Pace MC, Xu G, Fromholt S, Howard J, Crosby K, Giasson BI, Lewis J, Borchelt DR. Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease. Acta Neuropathologica. PMID 30140941 DOI: 10.1007/S00401-018-1895-Y |
0.708 |
|
| 2018 |
Pace MC, Xu G, Fromholt S, Howard J, Giasson BI, Lewis J, Borchelt DR. Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology. Molecular Neurodegeneration. 13: 23. PMID 29776378 DOI: 10.1186/S13024-018-0253-9 |
0.677 |
|
| 2018 |
Borchelt DR. Targeting the accomplice to thwart the culprit: a new target for the prevention of amyloid deposition. The Journal of Clinical Investigation. PMID 29600962 DOI: 10.1172/Jci120414 |
0.404 |
|
| 2018 |
Iradi MCG, Triplett JC, Thomas JD, Davila R, Crown AM, Brown H, Lewis J, Swanson MS, Xu G, Rodriguez-Lebron E, Borchelt DR. Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy. Scientific Reports. 8: 4049. PMID 29511296 DOI: 10.1038/S41598-018-21371-4 |
0.651 |
|
| 2017 |
Moloney C, Rayaprolu S, Howard J, Fromholt S, Brown H, Collins M, Cabrera M, Duffy C, Siemienski Z, Miller D, Swanson MS, Notterpek L, Borchelt DR, Lewis J. Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype. Acta Neuropathologica Communications. 5: 97. PMID 29237481 DOI: 10.1186/S40478-017-0502-0 |
0.426 |
|
| 2017 |
Moore BD, Martin J, de Mena L, Sanchez J, Cruz PE, Ceballos-Diaz C, Ladd TB, Ran Y, Levites Y, Kukar TL, Kurian JJ, McKenna R, Koo EH, Borchelt DR, Janus C, et al. Short Aβ peptides attenuate Aβ42 toxicity in vivo. The Journal of Experimental Medicine. PMID 29208777 DOI: 10.1084/Jem.20170600 |
0.415 |
|
| 2017 |
Ayers JI, Giasson BI, Borchelt DR. Prion-like Spreading in Tauopathies. Biological Psychiatry. PMID 28506438 DOI: 10.1016/J.Biopsych.2017.04.003 |
0.423 |
|
| 2017 |
Liu P, Reichl JH, Rao ER, McNellis BM, Huang ES, Hemmy LS, Forster CL, Kuskowski MA, Borchelt DR, Vassar R, Ashe KH, Zahs KR. Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice. Journal of Alzheimer's Disease : Jad. PMID 28059792 DOI: 10.3233/Jad-161027 |
0.503 |
|
| 2016 |
Moloney C, Rayaprolu S, Howard J, Fromholt S, Brown H, Collins M, Cabrera M, Duffy C, Siemienski Z, Miller D, Swanson MS, Notterpek L, Borchelt DR, Lewis J. Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype. Acta Neuropathologica Communications. 4: 122. PMID 27863507 DOI: 10.1186/S40478-016-0393-5 |
0.415 |
|
| 2016 |
Ayers JI, McMahon B, Gill S, Lelie HL, Fromholt S, Brown H, Valentine JS, Whitelegge JP, Borchelt DR. Relationship between mutant SOD1 maturation and inclusion formation in cell models. Journal of Neurochemistry. PMID 27727458 DOI: 10.1111/Jnc.13864 |
0.434 |
|
| 2016 |
Ayers JI, Diamond J, Sari A, Fromholt S, Galaleldeen A, Ostrow LW, Glass JD, Hart PJ, Borchelt DR. Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS. Acta Neuropathologica. PMID 27704280 DOI: 10.1007/S00401-016-1623-4 |
0.422 |
|
| 2016 |
Fromholt S, Reitano C, Brown H, Lewis J, Borchelt DR. Generation of a new transgenic mouse model for assessment of tau gene silencing therapies. Alzheimer's Research & Therapy. 8: 36. PMID 27593210 DOI: 10.1186/S13195-016-0202-1 |
0.381 |
|
| 2016 |
Melnikova T, Park D, Becker L, Lee D, Cho E, Sayyida N, Tian J, Bandeen-Roche K, Borchelt DR, Savonenko AV. Sex-related dimorphism in dentate gyrus atrophy and behavioral phenotypes in an inducible tTa:APPsi transgenic model of Alzheimer's disease. Neurobiology of Disease. PMID 27569580 DOI: 10.1016/J.Nbd.2016.08.009 |
0.379 |
|
| 2016 |
Liu Y, Pattamatta A, Zu T, Reid T, Bardhi O, Borchelt DR, Yachnis AT, Ranum LP. C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD. Neuron. PMID 27112499 DOI: 10.1016/J.Neuron.2016.04.005 |
0.416 |
|
| 2016 |
Xu G, Pattamatta A, Hildago R, Pace MC, Brown H, Borchelt DR. Vulnerability of newly synthesized proteins to proteostasis stress. Journal of Cell Science. 129: 1892-901. PMID 27026526 DOI: 10.1242/Jcs.176479 |
0.62 |
|
| 2016 |
Rayaprolu S, D'Alton S, Crosby K, Moloney C, Howard J, Duffy C, Cabrera M, Siemienski Z, Hernandez AR, Gallego-Iradi C, Borchelt DR, Lewis J. Heterogeneity of Matrin 3 in the developing and aging murine central nervous system. The Journal of Comparative Neurology. PMID 26878116 DOI: 10.1002/Cne.23986 |
0.349 |
|
| 2015 |
Ayers JI, Fromholt SE, O'Neal VM, Diamond JH, Borchelt DR. Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways. Acta Neuropathologica. PMID 26650262 DOI: 10.1007/S00401-015-1514-0 |
0.445 |
|
| 2015 |
Bañez-Coronel M, Ayhan F, Tarabochia AD, Zu T, Perez BA, Tusi SK, Pletnikova O, Borchelt DR, Ross CA, Margolis RL, Yachnis AT, Troncoso JC, Ranum LP. RAN Translation in Huntington Disease. Neuron. 88: 667-77. PMID 26590344 DOI: 10.1016/J.Neuron.2015.10.038 |
0.411 |
|
| 2015 |
Xu G, Ran Y, Fromholt SE, Fu C, Yachnis AT, Golde TE, Borchelt DR. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathologica Communications. 3: 72. PMID 26566997 DOI: 10.1186/S40478-015-0252-9 |
0.73 |
|
| 2015 |
Sacino AN, Ayers JI, Brooks MM, Chakrabarty P, Hudson VJ, Howard JK, Golde TE, Giasson BI, Borchelt DR. Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology. Acta Neuropathologica. PMID 26541429 DOI: 10.1007/S00401-015-1505-1 |
0.42 |
|
| 2015 |
Gallego-Iradi MC, Clare AM, Brown HH, Janus C, Lewis J, Borchelt DR. Subcellular Localization of Matrin 3 Containing Mutations Associated with ALS and Distal Myopathy. Plos One. 10: e0142144. PMID 26528920 DOI: 10.1371/Journal.Pone.0142144 |
0.376 |
|
| 2015 |
Janus C, Flores AY, Xu G, Borchelt DR. Behavioral abnormalities in APPSwe/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains. Neurobiology of Aging. 36: 2519-32. PMID 26089165 DOI: 10.1016/J.Neurobiolaging.2015.05.010 |
0.641 |
|
| 2015 |
Xu G, Fromholt S, Ayers JI, Brown H, Siemienski Z, Crosby KW, Mayer CA, Janus C, Borchelt DR. Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation. Journal of Neurochemistry. 133: 452-64. PMID 25557022 DOI: 10.1111/Jnc.13022 |
0.702 |
|
| 2015 |
Xu G, Ayers JI, Roberts BL, Brown H, Fromholt S, Green C, Borchelt DR. Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice. Human Molecular Genetics. 24: 1019-35. PMID 25305079 DOI: 10.1093/Hmg/Ddu517 |
0.703 |
|
| 2015 |
Ayers JI, Fromholt S, Sinyavskaya O, Siemienski Z, Rosario AM, Li A, Crosby KW, Cruz PE, DiNunno NM, Janus C, Ceballos-Diaz C, Borchelt DR, Golde TE, Chakrabarty P, Levites Y. Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 53-62. PMID 25228069 DOI: 10.1038/Mt.2014.180 |
0.311 |
|
| 2015 |
Melnikova T, Park DM, Porter S, Christie N, Borchelt DR, Savonenko A. Co-expression of app and tau accelerates cognitive decline in a new triple transgenic model that allows for accounting for the effect of age as a risk factor for Alzheimer’s disease Alzheimers & Dementia. 11: 852-853. DOI: 10.1016/J.Jalz.2015.08.018 |
0.363 |
|
| 2015 |
Zahs KR, Liu P, Hemmy LS, Reichl JH, Rao E, Forster CL, Vassar RJ, Borchelt DR, Ashe KH. Quantitative comparison of dense-core amyloid plaque burdens in Alzheimer’s disease patients and amyloid precursor protein transgenic mice Alzheimers & Dementia. 11: 353. DOI: 10.1016/J.Jalz.2015.06.236 |
0.507 |
|
| 2014 |
Ayers JI, Fromholt S, Koch M, DeBosier A, McMahon B, Xu G, Borchelt DR. Experimental transmissibility of mutant SOD1 motor neuron disease. Acta Neuropathologica. 128: 791-803. PMID 25262000 DOI: 10.1007/S00401-014-1342-7 |
0.696 |
|
| 2014 |
Brown HH, Borchelt DR. Analysis of mutant SOD1 electrophoretic mobility by Blue Native gel electrophoresis; evidence for soluble multimeric assemblies. Plos One. 9: e104583. PMID 25121776 DOI: 10.1371/Journal.Pone.0104583 |
0.413 |
|
| 2014 |
Tebbenkamp AT, Xu G, Siemienski ZB, Janus C, Fromholt SE, Brown HH, Swing D, Tessarollo L, Borchelt DR. Experimental mutagenesis of huntingtin to map cleavage sites: different outcomes in cell and mouse models. Journal of Huntington's Disease. 3: 73-86. PMID 25062766 DOI: 10.3233/Jhd-130087 |
0.795 |
|
| 2014 |
Sacino AN, Brooks M, Thomas MA, McKinney AB, Lee S, Regenhardt RW, McGarvey NH, Ayers JI, Notterpek L, Borchelt DR, Golde TE, Giasson BI. Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 10732-7. PMID 25002524 DOI: 10.1073/Pnas.1321785111 |
0.417 |
|
| 2014 |
Bourassa MW, Brown HH, Borchelt DR, Vogt S, Miller LM. Metal-deficient aggregates and diminished copper found in cells expressing SOD1 mutations that cause ALS. Frontiers in Aging Neuroscience. 6: 110. PMID 24982630 DOI: 10.3389/Fnagi.2014.00110 |
0.369 |
|
| 2014 |
Ayers JI, Xu G, Pletnikova O, Troncoso JC, Hart PJ, Borchelt DR. Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases. Acta Neuropathologica Communications. 2: 55. PMID 24887207 DOI: 10.1186/2051-5960-2-55 |
0.636 |
|
| 2014 |
Felsenstein KM, Candelario KM, Steindler DA, Borchelt DR. Regenerative medicine in Alzheimer's disease. Translational Research : the Journal of Laboratory and Clinical Medicine. 163: 432-8. PMID 24286919 DOI: 10.1016/J.Trsl.2013.11.001 |
0.334 |
|
| 2014 |
Ayers J, Lelie H, Workman A, Prudencio M, Brown H, Fromholt S, Valentine J, Whitelegge J, Borchelt D. Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease. Journal of Neurochemistry. 128: 305-14. PMID 24032979 DOI: 10.1111/Jnc.12451 |
0.697 |
|
| 2013 |
Qualls DA, Crosby K, Brown H, Borchelt DR. An analysis of interactions between fluorescently-tagged mutant and wild-type SOD1 in intracellular inclusions. Plos One. 8: e83981. PMID 24391857 DOI: 10.1371/Journal.Pone.0083981 |
0.465 |
|
| 2013 |
Qualls DA, Prudencio M, Roberts BL, Crosby K, Brown H, Borchelt DR. Features of wild-type human SOD1 limit interactions with misfolded aggregates of mouse G86R Sod1. Molecular Neurodegeneration. 8: 46. PMID 24341866 DOI: 10.1186/1750-1326-8-46 |
0.715 |
|
| 2013 |
Chakrabarty P, Rosario A, Cruz P, Siemienski Z, Ceballos-Diaz C, Crosby K, Jansen K, Borchelt DR, Kim JY, Jankowsky JL, Golde TE, Levites Y. Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain. Plos One. 8: e67680. PMID 23825679 DOI: 10.1371/Journal.Pone.0067680 |
0.662 |
|
| 2013 |
Chan PK, Chattopadhyay M, Sharma S, Souda P, Gralla EB, Borchelt DR, Whitelegge JP, Valentine JS. Structural similarity of wild-type and ALS-mutant superoxide dismutase-1 fibrils using limited proteolysis and atomic force microscopy. Proceedings of the National Academy of Sciences of the United States of America. 110: 10934-9. PMID 23781106 DOI: 10.1073/Pnas.1309613110 |
0.397 |
|
| 2013 |
Rutherford NJ, Lewis J, Clippinger AK, Thomas MA, Adamson J, Cruz PE, Cannon A, Xu G, Golde TE, Shaw G, Borchelt DR, Giasson BI. Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions. Brain Research. 1524: 62-73. PMID 23774650 DOI: 10.1016/J.Brainres.2013.06.006 |
0.7 |
|
| 2013 |
Price AR, Xu G, Siemienski ZB, Smithson LA, Borchelt DR, Golde TE, Felsenstein KM. Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (New York, N.Y.). 340: 924-d. PMID 23704553 DOI: 10.1126/science.1234089 |
0.637 |
|
| 2013 |
Clippinger AK, D'Alton S, Lin WL, Gendron TF, Howard J, Borchelt DR, Cannon A, Carlomagno Y, Chakrabarty P, Cook C, Golde TE, Levites Y, Ranum L, Schultheis PJ, Xu G, et al. Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy. Acta Neuropathologica. 126: 39-50. PMID 23666556 DOI: 10.1007/S00401-013-1123-8 |
0.754 |
|
| 2013 |
Kim J, Chakrabarty P, Hanna A, March A, Dickson DW, Borchelt DR, Golde T, Janus C. Normal cognition in transgenic BRI2-Aβ mice. Molecular Neurodegeneration. 8: 15. PMID 23663320 DOI: 10.1186/1750-1326-8-15 |
0.478 |
|
| 2013 |
Golde TE, Borchelt DR, Giasson BI, Lewis J. Thinking laterally about neurodegenerative proteinopathies. The Journal of Clinical Investigation. 123: 1847-55. PMID 23635781 DOI: 10.1172/Jci66029 |
0.36 |
|
| 2013 |
Xu G, Stevens SM, Moore BD, McClung S, Borchelt DR. Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis. Human Molecular Genetics. 22: 2765-74. PMID 23512986 DOI: 10.1093/Hmg/Ddt121 |
0.724 |
|
| 2013 |
Melnikova T, Fromholt S, Kim H, Lee D, Xu G, Price A, Moore BD, Golde TE, Felsenstein KM, Savonenko A, Borchelt DR. Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 3765-79. PMID 23447589 DOI: 10.1523/Jneurosci.4251-12.2013 |
0.679 |
|
| 2013 |
Golde TE, Felsenstein K, Chakrabarty P, Li A, Moore B, In JJ, Cruz P, Price A, Borchelt D, Janus C, Cebballos-Diaz C, Rosario A. Harnessing endogenous pathways and metabolites to treat or prevent neurodegenerative disease Molecular Neurodegeneration. 8. DOI: 10.1186/1750-1326-8-S1-O36 |
0.374 |
|
| 2012 |
Tebbenkamp AT, Crosby KW, Siemienski ZB, Brown HH, Golde TE, Borchelt DR. Analysis of proteolytic processes and enzymatic activities in the generation of huntingtin n-terminal fragments in an HEK293 cell model. Plos One. 7: e50750. PMID 23236391 DOI: 10.1371/Journal.Pone.0050750 |
0.797 |
|
| 2012 |
Xu G, Stevens SM, Kobeissy F, Kobiessy F, Brown H, McClung S, Gold MS, Borchelt DR. Identification of proteins sensitive to thermal stress in human neuroblastoma and glioma cell lines. Plos One. 7: e49021. PMID 23145051 DOI: 10.1371/Journal.Pone.0049021 |
0.599 |
|
| 2012 |
Roberts BL, Patel K, Brown HH, Borchelt DR. Role of disulfide cross-linking of mutant SOD1 in the formation of inclusion-body-like structures. Plos One. 7: e47838. PMID 23118898 DOI: 10.1371/Journal.Pone.0047838 |
0.375 |
|
| 2012 |
Shi Y, Mowery RA, Ashley J, Hentz M, Ramirez AJ, Bilgicer B, Slunt-Brown H, Borchelt DR, Shaw BF. Abnormal SDS-PAGE migration of cytosolic proteins can identify domains and mechanisms that control surfactant binding. Protein Science : a Publication of the Protein Society. 21: 1197-209. PMID 22692797 DOI: 10.1002/Pro.2107 |
0.312 |
|
| 2012 |
Xu G, Green CC, Fromholt SE, Borchelt DR. Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice. Alzheimer's Research & Therapy. 4: 12. PMID 22537779 DOI: 10.1186/Alzrt110 |
0.685 |
|
| 2012 |
Njie eG, Kantorovich S, Astary GW, Green C, Zheng T, Semple-Rowland SL, Steindler DA, Sarntinoranont M, Streit WJ, Borchelt DR. A preclinical assessment of neural stem cells as delivery vehicles for anti-amyloid therapeutics. Plos One. 7: e34097. PMID 22496779 DOI: 10.1371/Journal.Pone.0034097 |
0.797 |
|
| 2012 |
Prudencio M, Lelie H, Brown HH, Whitelegge JP, Valentine JS, Borchelt DR. A novel variant of human superoxide dismutase 1 harboring amyotrophic lateral sclerosis-associated and experimental mutations in metal-binding residues and free cysteines lacks toxicity in vivo. Journal of Neurochemistry. 121: 475-85. PMID 22332887 DOI: 10.1111/J.1471-4159.2012.07690.X |
0.662 |
|
| 2012 |
Njie EG, Boelen E, Stassen FR, Steinbusch HW, Borchelt DR, Streit WJ. Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function. Neurobiology of Aging. 33: 195.e1-12. PMID 20580465 DOI: 10.1016/J.Neurobiolaging.2010.05.008 |
0.791 |
|
| 2011 |
Prudencio M, Borchelt DR. Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states. Molecular Neurodegeneration. 6: 77. PMID 22094223 DOI: 10.1186/1750-1326-6-77 |
0.666 |
|
| 2011 |
Tebbenkamp AT, Green C, Xu G, Denovan-Wright EM, Rising AC, Fromholt SE, Brown HH, Swing D, Mandel RJ, Tessarollo L, Borchelt DR. Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative. Human Molecular Genetics. 20: 2770-82. PMID 21515588 DOI: 10.1093/Hmg/Ddr176 |
0.819 |
|
| 2011 |
Chen KA, Cruz PE, Lanuto DJ, Flotte TR, Borchelt DR, Srivastava A, Zhang J, Steindler DA, Zheng T. Cellular fusion for gene delivery to SCA1 affected Purkinje neurons. Molecular and Cellular Neurosciences. 47: 61-70. PMID 21420496 DOI: 10.1016/J.Mcn.2011.03.003 |
0.329 |
|
| 2011 |
Tebbenkamp AT, Swing D, Tessarollo L, Borchelt DR. Premature death and neurologic abnormalities in transgenic mice expressing a mutant huntingtin exon-2 fragment. Human Molecular Genetics. 20: 1633-42. PMID 21307087 DOI: 10.1093/Hmg/Ddr040 |
0.827 |
|
| 2011 |
Lelie HL, Liba A, Bourassa MW, Chattopadhyay M, Chan PK, Gralla EB, Miller LM, Borchelt DR, Valentine JS, Whitelegge JP. Copper and zinc metallation status of copper-zinc superoxide dismutase from amyotrophic lateral sclerosis transgenic mice. The Journal of Biological Chemistry. 286: 2795-806. PMID 21068388 DOI: 10.1074/Jbc.M110.186999 |
0.371 |
|
| 2011 |
Liu Y, Lee MK, James MM, Price DL, Borchelt DR, Troncoso JC, Oh ES. Passive (amyloid-β) immunotherapy attenuates monoaminergic axonal degeneration in the AβPPswe/PS1dE9 mice. Journal of Alzheimer's Disease : Jad. 23: 271-9. PMID 20966549 DOI: 10.3233/Jad-2010-101602 |
0.541 |
|
| 2011 |
Xu G, Stevens S, Kobeissy F, Gold M, Borchelt D. P3-144: Alzheimer's amyloidosis induces global changes in protein homeostasis in the brains of transgenic mice Alzheimer's & Dementia. 7: S562-S562. DOI: 10.1016/J.Jalz.2011.05.1584 |
0.725 |
|
| 2010 |
Tebbenkamp AT, Borchelt DR. Analysis of chaperone mRNA expression in the adult mouse brain by meta analysis of the Allen Brain Atlas. Plos One. 5: e13675. PMID 21060842 DOI: 10.1371/Journal.Pone.0013675 |
0.799 |
|
| 2010 |
Prudencio M, Durazo A, Whitelegge JP, Borchelt DR. An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1. Human Molecular Genetics. 19: 4774-89. PMID 20871097 DOI: 10.1093/Hmg/Ddq408 |
0.711 |
|
| 2010 |
Karch CM, Borchelt DR. Aggregation modulating elements in mutant human superoxide dismutase 1. Archives of Biochemistry and Biophysics. 503: 175-82. PMID 20682279 DOI: 10.1016/J.Abb.2010.07.027 |
0.646 |
|
| 2010 |
Klevytska AM, Tebbenkamp AT, Savonenko AV, Borchelt DR. Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease. Journal of Neuropathology and Experimental Neurology. 69: 396-404. PMID 20448484 DOI: 10.1097/Nen.0B013E3181D6C436 |
0.814 |
|
| 2010 |
Smith WW, Liu Z, Liang Y, Masuda N, Swing DA, Jenkins NA, Copeland NG, Troncoso JC, Pletnikov M, Dawson TM, Martin LJ, Moran TH, Lee MK, Borchelt DR, Ross CA. Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model. Human Molecular Genetics. 19: 2087-98. PMID 20185556 DOI: 10.1093/Hmg/Ddq086 |
0.374 |
|
| 2010 |
Karch CM, Borchelt DR. An examination of alpha B-crystallin as a modifier of SOD1 aggregate pathology and toxicity in models of familial amyotrophic lateral sclerosis. Journal of Neurochemistry. 113: 1092-100. PMID 20067574 DOI: 10.1111/J.1471-4159.2010.06572.X |
0.657 |
|
| 2010 |
Winkler DD, Prudencio M, Karch C, Borchelt DR, Hart PJ. Copper-Zinc Superoxide Dismutase, Its Copper Chaperone, and Familial Amyotrophic Lateral Sclerosis Protein Misfolding Diseases: Current and Emerging Principles and Therapies. 381-401. DOI: 10.1002/9780470572702.ch17 |
0.669 |
|
| 2009 |
Tebbenkamp AT, Borchelt DR. Protein aggregate characterization in models of neurodegenerative disease. Methods in Molecular Biology (Clifton, N.J.). 566: 85-91. PMID 20058166 DOI: 10.1007/978-1-59745-562-6_6 |
0.834 |
|
| 2009 |
Seetharaman SV, Prudencio M, Karch C, Holloway SP, Borchelt DR, Hart PJ. Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis. Experimental Biology and Medicine (Maywood, N.J.). 234: 1140-54. PMID 19596823 DOI: 10.3181/0903-Mr-104 |
0.768 |
|
| 2009 |
Prudencio M, Hart PJ, Borchelt DR, Andersen PM. Variation in aggregation propensities among ALS-associated variants of SOD1: correlation to human disease. Human Molecular Genetics. 18: 3217-26. PMID 19483195 DOI: 10.1093/Hmg/Ddp260 |
0.667 |
|
| 2009 |
Karch CM, Prudencio M, Winkler DD, Hart PJ, Borchelt DR. Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS. Proceedings of the National Academy of Sciences of the United States of America. 106: 7774-9. PMID 19416874 DOI: 10.1073/Pnas.0902505106 |
0.781 |
|
| 2009 |
Winkler DD, Schuermann JP, Cao X, Holloway SP, Borchelt DR, Carroll MC, Proescher JB, Culotta VC, Hart PJ. Structural and biophysical properties of the pathogenic SOD1 variant H46R/H48Q. Biochemistry. 48: 3436-47. PMID 19227972 DOI: 10.1021/Bi8021735 |
0.435 |
|
| 2009 |
Prudencio M, Durazo A, Whitelegge JP, Borchelt DR. Modulation of mutant superoxide dismutase 1 aggregation by co-expression of wild-type enzyme. Journal of Neurochemistry. 108: 1009-18. PMID 19077113 DOI: 10.1111/J.1471-4159.2008.05839.X |
0.718 |
|
| 2009 |
Oh ES, Savonenko AV, King JF, Fangmark Tucker SM, Rudow GL, Xu G, Borchelt DR, Troncoso JC. Amyloid precursor protein increases cortical neuron size in transgenic mice. Neurobiology of Aging. 30: 1238-44. PMID 18304698 DOI: 10.1016/J.Neurobiolaging.2007.12.024 |
0.708 |
|
| 2009 |
Tomiyama T, Matsuyama S, Iso H, Takuma H, Umeda T, Ohnishi K, Teraoka R, Ishibashi K, Nishitsuji K, Ito K, Borchelt DR, Lambert MP, Klein WL, Mori H. A transgenic mouse model of amyloid β oligomers: Pathological effects of the E693Δ mutation in amyloid precursor protein in vivo Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.05.367 |
0.449 |
|
| 2008 |
Liu Y, Yoo MJ, Savonenko A, Stirling W, Price DL, Borchelt DR, Mamounas L, Lyons WE, Blue ME, Lee MK. Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13805-14. PMID 19091971 DOI: 10.1523/Jneurosci.4218-08.2008 |
0.594 |
|
| 2008 |
Xu G, Karch C, Li N, Lin N, Fromholt D, Gonzales V, Borchelt DR. Receptor-associated protein (RAP) plays a central role in modulating Abeta deposition in APP/PS1 transgenic mice. Plos One. 3: e3159. PMID 18776935 DOI: 10.1371/Journal.Pone.0003159 |
0.749 |
|
| 2008 |
Muller FL, Liu Y, Jernigan A, Borchelt D, Richardson A, Van Remmen H. MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models Muscle and Nerve. 38: 1173-1183. PMID 18720509 DOI: 10.1002/Mus.21049 |
0.419 |
|
| 2008 |
Chang Y, Kong Q, Shan X, Tian G, Ilieva H, Cleveland DW, Rothstein JD, Borchelt DR, Wong PC, Lin CL. Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. Plos One. 3: e2849. PMID 18682740 DOI: 10.1371/Journal.Pone.0002849 |
0.357 |
|
| 2008 |
Karch CM, Borchelt DR. A limited role for disulfide cross-linking in the aggregation of mutant SOD1 linked to familial amyotrophic lateral sclerosis. The Journal of Biological Chemistry. 283: 13528-37. PMID 18316367 DOI: 10.1074/Jbc.M800564200 |
0.647 |
|
| 2008 |
Shaw BF, Lelie HL, Durazo A, Nersissian AM, Xu G, Chan PK, Gralla EB, Tiwari A, Hayward LJ, Borchelt DR, Valentine JS, Whitelegge JP. Detergent-insoluble aggregates associated with amyotrophic lateral sclerosis in transgenic mice contain primarily full-length, unmodified superoxide dismutase-1. The Journal of Biological Chemistry. 283: 8340-50. PMID 18192269 DOI: 10.1074/Jbc.M707751200 |
0.678 |
|
| 2008 |
Tucker SM, Borchelt DR, Troncoso JC. Limited clearance of pre-existing amyloid plaques after intracerebral injection of Abeta antibodies in two mouse models of Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 67: 30-40. PMID 18091561 DOI: 10.1097/Nen.0B013E31815F38D2 |
0.683 |
|
| 2008 |
Wang J, Martin E, Gonzales V, Borchelt DR, Lee MK. Differential regulation of small heat shock proteins in transgenic mouse models of neurodegenerative diseases. Neurobiology of Aging. 29: 586-97. PMID 17316906 DOI: 10.1016/J.Neurobiolaging.2006.11.009 |
0.559 |
|
| 2008 |
Borchelt DR, Savonenko AV. Chapter 5.5 Transgenic mouse models of Alzheimer's disease and episodic-like memory Handbook of Behavioral Neuroscience. 18: 553-573. DOI: 10.1016/S1569-7339(08)00230-0 |
0.338 |
|
| 2007 |
Ratovitski T, Nakamura M, D'Ambola J, Chighladze E, Liang Y, Wang W, Graham R, Hayden MR, Borchelt DR, Hirschhorn RR, Ross CA. N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease. Cell Cycle (Georgetown, Tex.). 6: 2970-81. PMID 18156806 DOI: 10.4161/Cc.6.23.4992 |
0.373 |
|
| 2007 |
Verret L, Jankowsky JL, Xu GM, Borchelt DR, Rampon C. Alzheimer's-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6771-80. PMID 17581964 DOI: 10.1523/Jneurosci.5564-06.2007 |
0.799 |
|
| 2007 |
Jankowsky JL, Younkin LH, Gonzales V, Fadale DJ, Slunt HH, Lester HA, Younkin SG, Borchelt DR. Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice. The Journal of Biological Chemistry. 282: 22707-20. PMID 17556372 DOI: 10.1074/Jbc.M611050200 |
0.72 |
|
| 2007 |
Schilling G, Klevytska A, Tebbenkamp AT, Juenemann K, Cooper J, Gonzales V, Slunt H, Poirer M, Ross CA, Borchelt DR. Characterization of huntingtin pathologic fragments in human Huntington disease, transgenic mice, and cell models. Journal of Neuropathology and Experimental Neurology. 66: 313-20. PMID 17413322 DOI: 10.1097/Nen.0B013E318040B2C8 |
0.809 |
|
| 2007 |
Wang J, Caruano-Yzermans A, Rodriguez A, Scheurmann JP, Slunt HH, Cao X, Gitlin J, Hart PJ, Borchelt DR. Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability. The Journal of Biological Chemistry. 282: 345-52. PMID 17092942 DOI: 10.1074/Jbc.M604503200 |
0.493 |
|
| 2007 |
Tucker SM, Oh E, Borchelt D, Troncoso J. Biotinylated anti-Aβ antibody as a tool to diagnose pre-clinical stages of Alzheimer disease (AD) Journal of Neuropathology and Experimental Neurology. 66: 419-420. DOI: 10.1097/01.Jnen.0000268981.06535.85 |
0.631 |
|
| 2007 |
Tucker SM, Oh E, Borchelt D, Troncoso J. Biotinylated anti-A{beta} antibody as a tool to diagnose pre-clinical stages of Alzheimer's Disease (AD) The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A20-A |
0.623 |
|
| 2007 |
Oh E, Tucker S, Borchelt D, Troncoso J. P-053: Use of a biotinylated anti-Aβ antibody to diagnose preclinical Alzheimer's disease Alzheimer's & Dementia. 3: S114-S115. DOI: 10.1016/J.Jalz.2007.04.306 |
0.634 |
|
| 2006 |
Zamora E, Handisurya A, Shafti-Keramat S, Borchelt D, Rudow G, Conant K, Cox C, Troncoso JC, Kirnbauer R. Papillomavirus-like particles are an effective platform for amyloid-beta immunization in rabbits and transgenic mice. Journal of Immunology (Baltimore, Md. : 1950). 177: 2662-70. PMID 16888028 DOI: 10.4049/Jimmunol.177.4.2662 |
0.422 |
|
| 2006 |
Wang J, Xu G, Borchelt DR. Mapping superoxide dismutase 1 domains of non-native interaction: roles of intra- and intermolecular disulfide bonding in aggregation. Journal of Neurochemistry. 96: 1277-88. PMID 16441516 DOI: 10.1111/J.1471-4159.2005.03642.X |
0.704 |
|
| 2006 |
Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, Crippen D, Wood JD, Sawa A, Jenkins NA, Copeland NG, Borchelt DR, Ross CA, Ellerby LM. Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin. Neurobiology of Disease. 21: 381-91. PMID 16150600 DOI: 10.1016/J.Nbd.2005.07.014 |
0.506 |
|
| 2005 |
Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC. BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11693-709. PMID 16354928 DOI: 10.1523/Jneurosci.2766-05.2005 |
0.728 |
|
| 2005 |
Jankowsky JL, Slunt HH, Gonzales V, Savonenko AV, Wen JC, Jenkins NA, Copeland NG, Younkin LH, Lester HA, Younkin SG, Borchelt DR. Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. Plos Medicine. 2: e355. PMID 16279840 DOI: 10.1371/Journal.Pmed.0020355 |
0.744 |
|
| 2005 |
Jenkins BG, Andreassen OA, Dedeoglu A, Leavitt B, Hayden M, Borchelt D, Ross CA, Ferrante RJ, Beal MF. Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease. Journal of Neurochemistry. 95: 553-62. PMID 16135087 DOI: 10.1111/J.1471-4159.2005.03411.X |
0.438 |
|
| 2005 |
Wang J, Xu G, Slunt HH, Gonzales V, Coonfield M, Fromholt D, Copeland NG, Jenkins NA, Borchelt DR. Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA. Neurobiology of Disease. 20: 943-52. PMID 16046140 DOI: 10.1016/J.Nbd.2005.06.005 |
0.762 |
|
| 2005 |
Wang J, Xu G, Li H, Gonzales V, Fromholt D, Karch C, Copeland NG, Jenkins NA, Borchelt DR. Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: alphaB-crystallin modulates aggregation. Human Molecular Genetics. 14: 2335-47. PMID 16000321 DOI: 10.1093/Hmg/Ddi236 |
0.804 |
|
| 2005 |
Jankowsky JL, Melnikova T, Fadale DJ, Xu GM, Slunt HH, Gonzales V, Younkin LH, Younkin SG, Borchelt DR, Savonenko AV. Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5217-24. PMID 15917461 DOI: 10.1523/Jneurosci.5080-04.2005 |
0.802 |
|
| 2005 |
Savonenko A, Xu GM, Melnikova T, Morton JL, Gonzales V, Wong MP, Price DL, Tang F, Markowska AL, Borchelt DR. Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities. Neurobiology of Disease. 18: 602-17. PMID 15755686 DOI: 10.1016/J.Nbd.2004.10.022 |
0.776 |
|
| 2005 |
Price DL, Borchelt DR, Lee MK, Wong PC. Selected genetically engineered models relevant to human neurodegenerative disease Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics. 176-195. DOI: 10.1017/CBO9780511544873.016 |
0.373 |
|
| 2005 |
Jankowsky JL, Melnikova T, Fadale DJ, Xu GM, Slunt HH, Gonzales V, Younkin LH, Younkin SG, Borchelt DR, Savonenko AV. [O2-03-01]: Environmental enrichment mitigates cognitive deficits in APP/PS1 transgenic mice Alzheimer's & Dementia. 1: S99-S99. DOI: 10.1016/J.Jalz.2005.06.342 |
0.76 |
|
| 2005 |
Price DL, Borchelt DR, Wong PC. Alzheimer's Disease. Clinical Features, Neuropathological and Biochemical Abnormalities, Genetics, Models, and Experimental Therapeutics From Neuroscience to Neurology. 445-458. DOI: 10.1016/B978-012738903-5/50028-X |
0.42 |
|
| 2004 |
Jankowsky JL, Slunt HH, Gonzales V, Jenkins NA, Copeland NG, Borchelt DR. APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1. Neurobiology of Aging. 25: 885-92. PMID 15212842 DOI: 10.1016/J.Neurobiolaging.2003.09.008 |
0.764 |
|
| 2004 |
Schilling G, Savonenko AV, Klevytska A, Morton JL, Tucker SM, Poirier M, Gale A, Chan N, Gonzales V, Slunt HH, Coonfield ML, Jenkins NA, Copeland NG, Ross CA, Borchelt DR. Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice. Human Molecular Genetics. 13: 1599-610. PMID 15190011 DOI: 10.1093/Hmg/Ddh175 |
0.822 |
|
| 2004 |
Schilling G, Savonenko AV, Coonfield ML, Morton JL, Vorovich E, Gale A, Neslon C, Chan N, Eaton M, Fromholt D, Ross CA, Borchelt DR. Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice. Experimental Neurology. 187: 137-49. PMID 15081595 DOI: 10.1016/J.Expneurol.2004.01.003 |
0.406 |
|
| 2004 |
Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Human Molecular Genetics. 13: 159-70. PMID 14645205 DOI: 10.1093/Hmg/Ddh019 |
0.799 |
|
| 2004 |
Zamora ED, Conant K, Hillaire C, Handisurya A, Kirnbauer R, Rudow G, Borchelt D, Troncoso J. P4-343 Papilomarvirus0like particle Aβ vaccine induces specific antibody response, and prevents behavioral impairment in APP/PS1 transgenic mice Neurobiology of Aging. 25: S572-S573. DOI: 10.1016/S0197-4580(04)81901-8 |
0.351 |
|
| 2004 |
Liu L, Jankowsky J, Kordylewska A, Veselits M, Utset M, Borchelt D, Thinakaran G. P4-310 Role of presenilin1-β-catenin interaction in embryonic development Neurobiology of Aging. 25: S563. DOI: 10.1016/S0197-4580(04)81868-2 |
0.606 |
|
| 2004 |
Jankowsky JL, Wen J, Slunt HH, Gonzales V, Jenkins NA, Copeland NG, Borchelt DR. P2-038 Inhibition of beta-amyloid production and clearance of senile plaques in transgenic mice Neurobiology of Aging. 25: S234. DOI: 10.1016/S0197-4580(04)80785-1 |
0.701 |
|
| 2004 |
Cai H, Wen H, Laird FM, Chiang H, Xu G, Borchelt DR, Price DL, Wong PC. P1-222 Deletion of BACE1 prevents age-associated neuropathological abnormalities in mutant APP;PS1 mice Neurobiology of Aging. 25: S159. DOI: 10.1016/S0197-4580(04)80535-9 |
0.718 |
|
| 2004 |
Laird FM, Savonenko AV, Melnikova T, Cai H, Borchelt DR, Price DL, Wong PC. P1-179 Age-associated memory deficits occurring in Bace1-deficient mice or APP;PS1 mice are restored in APP;PS1 mice lacking BACE1: a role for APP and BACE1 in cognition Neurobiology of Aging. 25: S146. DOI: 10.1016/S0197-4580(04)80492-5 |
0.555 |
|
| 2004 |
Borchelt DR, Xu G, Wang J, Gonzales V. O4-02-01 Role of LRP and RAP in amyloid deposition Neurobiology of Aging. 25: S75. DOI: 10.1016/S0197-4580(04)80256-2 |
0.661 |
|
| 2004 |
Wong PC, Cai H, Laird FM, Savonenko AV, Melnikova T, Price DL, Borchelt DR, Xu G. S1-01-02 A role for APP and BACE1 in cognition Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80005-8 |
0.641 |
|
| 2003 |
Jankowsky JL, Xu G, Fromholt D, Gonzales V, Borchelt DR. Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 62: 1220-7. PMID 14692698 DOI: 10.1093/Jnen/62.12.1220 |
0.812 |
|
| 2003 |
Sheng JG, Bora SH, Xu G, Borchelt DR, Price DL, Koliatsos VE. Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice. Neurobiology of Disease. 14: 133-45. PMID 13678674 DOI: 10.1016/S0969-9961(03)00069-X |
0.747 |
|
| 2003 |
Wang J, Slunt H, Gonzales V, Fromholt D, Coonfield M, Copeland NG, Jenkins NA, Borchelt DR. Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature. Human Molecular Genetics. 12: 2753-64. PMID 12966034 DOI: 10.1093/Hmg/Ddg312 |
0.586 |
|
| 2003 |
Savonenko AV, Xu GM, Price DL, Borchelt DR, Markowska AL. Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APP SWE. Neurobiology of Disease. 12: 194-211. PMID 12742740 DOI: 10.1016/S0969-9961(02)00012-8 |
0.752 |
|
| 2003 |
Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. APP processing and synaptic function. Neuron. 37: 925-37. PMID 12670422 DOI: 10.1016/S0896-6273(03)00124-7 |
0.388 |
|
| 2003 |
Schilling G, Borchelt DR. Identifying new therapeutics for Huntington's disease Clinical Neuroscience Research. 3: 179-186. DOI: 10.1016/S1566-2772(03)00060-4 |
0.353 |
|
| 2002 |
Kratz JE, Stearns D, Huso DL, Slunt HH, Price DL, Borchelt DR, Eberhart CG. Expression of stabilized beta-catenin in differentiated neurons of transgenic mice does not result in tumor formation. Bmc Cancer. 2: 33. PMID 12460454 DOI: 10.1186/1471-2407-2-33 |
0.539 |
|
| 2002 |
Estus S, Borchelt D, Kindy MS, Vassar R. Abeta deposition is essential to AD neuropathology. Journal of Alzheimer's Disease : Jad. 4: 133-8. PMID 12226531 DOI: 10.3233/Jad-2002-4302 |
0.347 |
|
| 2002 |
Xu G, Gonzales V, Borchelt DR. Abeta deposition does not cause the aggregation of endogenous tau in transgenic mice. Alzheimer Disease and Associated Disorders. 16: 196-201. PMID 12218652 DOI: 10.1097/00002093-200207000-00011 |
0.713 |
|
| 2002 |
Xu G, Gonzales V, Borchelt DR. Rapid detection of protein aggregates in the brains of Alzheimer patients and transgenic mouse models of amyloidosis. Alzheimer Disease and Associated Disorders. 16: 191-5. PMID 12218651 DOI: 10.1097/00002093-200207000-00010 |
0.684 |
|
| 2002 |
Jankowsky JL, Savonenko A, Schilling G, Wang J, Xu G, Borchelt DR. Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development. Current Neurology and Neuroscience Reports. 2: 457-64. PMID 12169227 DOI: 10.1007/S11910-002-0073-7 |
0.798 |
|
| 2002 |
Luthi-Carter R, Strand AD, Hanson SA, Kooperberg C, Schilling G, La Spada AR, Merry DE, Young AB, Ross CA, Borchelt DR, Olson JM. Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects. Human Molecular Genetics. 11: 1927-37. PMID 12165555 DOI: 10.1093/Hmg/11.17.1927 |
0.424 |
|
| 2002 |
Wang J, Xu G, Gonzales V, Coonfield M, Fromholt D, Copeland NG, Jenkins NA, Borchelt DR. Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site. Neurobiology of Disease. 10: 128-38. PMID 12127151 DOI: 10.1006/Nbdi.2002.0498 |
0.738 |
|
| 2002 |
Wong PC, Cai H, Borchelt DR, Price DL. Genetically engineered mouse models of neurodegenerative diseases. Nature Neuroscience. 5: 633-9. PMID 12085093 DOI: 10.1038/Nn0702-633 |
0.531 |
|
| 2002 |
Xiang Z, Ho L, Valdellon J, Borchelt D, Kelley K, Spielman L, Aisen PS, Pasinetti GM. Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology. Neurobiology of Aging. 23: 327-34. PMID 11959394 DOI: 10.1016/S0197-4580(01)00282-2 |
0.474 |
|
| 2002 |
Wheeler VC, Gutekunst CA, Vrbanac V, Lebel LA, Schilling G, Hersch S, Friedlander RM, Gusella JF, Vonsattel JP, Borchelt DR, MacDonald ME. Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice. Human Molecular Genetics. 11: 633-40. PMID 11912178 DOI: 10.1093/Hmg/11.6.633 |
0.491 |
|
| 2002 |
Wang J, Xu G, Borchelt DR. High molecular weight complexes of mutant superoxide dismutase 1: age-dependent and tissue-specific accumulation. Neurobiology of Disease. 9: 139-48. PMID 11895367 DOI: 10.1006/Nbdi.2001.0471 |
0.725 |
|
| 2002 |
Borchelt DR, Lee MK, Gonzales V, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Price DL, Sisodia SS. Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice. Neurobiology of Aging. 23: 171-7. PMID 11804700 DOI: 10.1016/S0197-4580(01)00280-9 |
0.604 |
|
| 2002 |
Price D, Cai H, Savonenko A, Borchelt D, Wong P. The value of transgenic and gene targeted models for experimental therapeutics of Alzheimer's disease European Neuropsychopharmacology. 12: 131. DOI: 10.1016/S0924-977X(02)80072-4 |
0.442 |
|
| 2001 |
Wong PC, Cai H, Borchelt DR, Price DL. Genetically engineered models relevant to neurodegenerative disorders: their value for understanding disease mechanisms and designing/testing experimental therapeutics. Journal of Molecular Neuroscience : Mn. 17: 233-57. PMID 11816796 DOI: 10.1385/Jmn:17:2:233 |
0.509 |
|
| 2001 |
Vehmas AK, Borchelt DR, Price DL, McCarthy D, Wills-Karp M, Peper MJ, Rudow G, Luyinbazi J, Siew LT, Troncoso JC. beta-Amyloid peptide vaccination results in marked changes in serum and brain Abeta levels in APPswe/PS1DeltaE9 mice, as detected by SELDI-TOF-based ProteinChip technology. Dna and Cell Biology. 20: 713-21. PMID 11788049 DOI: 10.1089/10445490152717578 |
0.572 |
|
| 2001 |
Schilling G, Coonfield ML, Ross CA, Borchelt DR. Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model. Neuroscience Letters. 315: 149-53. PMID 11716985 DOI: 10.1016/S0304-3940(01)02326-6 |
0.351 |
|
| 2001 |
Lesuisse C, Xu G, Anderson J, Wong M, Jankowsky J, Holtz G, Gonzalez V, Wong PC, Price DL, Tang F, Wagner S, Borchelt DR. Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice. Human Molecular Genetics. 10: 2525-37. PMID 11709540 DOI: 10.1093/Hmg/10.22.2525 |
0.818 |
|
| 2001 |
Andreassen OA, Ferrante RJ, Huang HM, Dedeoglu A, Park L, Ferrante KL, Kwon J, Borchelt DR, Ross CA, Gibson GE, Beal MF. Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease. Annals of Neurology. 50: 112-7. PMID 11456300 DOI: 10.1002/Ana.1085 |
0.41 |
|
| 2001 |
Andreassen OA, Dedeoglu A, Ferrante RJ, Jenkins BG, Ferrante KL, Thomas M, Friedlich A, Browne SE, Schilling G, Borchelt DR, Hersch SM, Ross CA, Beal MF. Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiology of Disease. 8: 479-91. PMID 11447996 DOI: 10.1006/Nbdi.2001.0406 |
0.381 |
|
| 2001 |
Schilling G, Jinnah HA, Gonzales V, Coonfield ML, Kim Y, Wood JD, Price DL, Li XJ, Jenkins N, Copeland N, Moran T, Ross CA, Borchelt DR. Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA. Neurobiology of Disease. 8: 405-18. PMID 11442350 DOI: 10.1006/Nbdi.2001.0385 |
0.621 |
|
| 2001 |
Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Borchelt DR. Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomolecular Engineering. 17: 157-65. PMID 11337275 DOI: 10.1016/S1389-0344(01)00067-3 |
0.682 |
|
| 2001 |
Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nature Neuroscience. 4: 233-4. PMID 11224536 DOI: 10.1038/85064 |
0.558 |
|
| 2000 |
Price DL, Wong PC, Markowska AL, Lee MK, Thinakaren G, Cleveland DW, Sisodia SS, Borchelt DR. The value of transgenic models for the study of neurodegenerative diseases. Annals of the New York Academy of Sciences. 920: 179-91. PMID 11193148 DOI: 10.1111/J.1749-6632.2000.Tb06920.X |
0.569 |
|
| 2000 |
Takahashi M, Doré S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim SH, Thinakaran G, Sisodia SS, Snyder SH. Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease. Neuron. 28: 461-73. PMID 11144356 DOI: 10.1016/S0896-6273(00)00125-2 |
0.509 |
|
| 2000 |
Luthi-Carter R, Strand A, Peters NL, Solano SM, Hollingsworth ZR, Menon AS, Frey AS, Spektor BS, Penney EB, Schilling G, Ross CA, Borchelt DR, Tapscott SJ, Young AB, Cha JH, et al. Decreased expression of striatal signaling genes in a mouse model of Huntington's disease. Human Molecular Genetics. 9: 1259-71. PMID 10814708 DOI: 10.1093/Hmg/9.9.1259 |
0.381 |
|
| 2000 |
Zaman SH, Parent A, Laskey A, Lee MK, Borchelt DR, Sisodia SS, Malinow R. Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine. Neurobiology of Disease. 7: 54-63. PMID 10671322 DOI: 10.1006/Nbdi.1999.0271 |
0.435 |
|
| 2000 |
Borchelt DR, Lesuisse C, Gonzales V, Anderson J, Lee MK, Price DL, Wong PC, Wagner S. APP and PS-1 transgenic mice Neurobiology of Aging. 21: 76. DOI: 10.1016/S0197-4580(00)82566-X |
0.567 |
|
| 2000 |
Jankowsky JL, Slunt HH, Borchelt DR. Tetracycline-controlled expression of presenilin-1 in transgenic mice Neurobiology of Aging. 21: 154. DOI: 10.1016/S0197-4580(00)82029-1 |
0.694 |
|
| 1999 |
Schilling G, Wood JD, Duan K, Slunt HH, Gonzales V, Yamada M, Cooper JK, Margolis RL, Jenkins NA, Copeland NG, Takahashi H, Tsuji S, Price DL, Borchelt DR, Ross CA. Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA. Neuron. 24: 275-86. PMID 10677044 DOI: 10.1016/S0896-6273(00)80839-9 |
0.601 |
|
| 1999 |
Ross CA, Wood JD, Schilling G, Peters MF, Nucifora FC, Cooper JK, Sharp AH, Margolis RL, Borchelt DR. Polyglutamine pathogenesis. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 354: 1005-11. PMID 10434299 DOI: 10.1098/rstb.1999.0452 |
0.352 |
|
| 1999 |
Ratovitski T, Corson LB, Strain J, Wong P, Cleveland DW, Culotta VC, Borchelt DR. Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds. Human Molecular Genetics. 8: 1451-60. PMID 10400992 DOI: 10.1093/Hmg/8.8.1451 |
0.327 |
|
| 1999 |
Iadecola C, Zhang F, Niwa K, Eckman C, Turner SK, Fischer E, Younkin S, Borchelt DR, Hsiao KK, Carlson GA. SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nature Neuroscience. 2: 157-61. PMID 10195200 DOI: 10.1038/5715 |
0.466 |
|
| 1999 |
Parent A, Linden DJ, Sisodia SS, Borchelt DR. Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1. Neurobiology of Disease. 6: 56-62. PMID 10078973 DOI: 10.1006/Nbdi.1998.0207 |
0.383 |
|
| 1999 |
Schilling G, Becher MW, Sharp AH, Jinnah HA, Duan K, Kotzuk JA, Slunt HH, Ratovitski T, Cooper JK, Jenkins NA, Copeland NG, Price DL, Ross CA, Borchelt DR. Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Human Molecular Genetics. 8: 397-407. PMID 9949199 DOI: 10.1093/Hmg/8.3.397 |
0.583 |
|
| 1999 |
Schilling G, Becher MW, Sharp AH, Jinnah HA, Duan K, Kotzuk JA, Slunt HH, Ratovitski T, Cooper JK, Jenkins NA, Copeland NG, Price DL, Ross CA, Borchelt DR. Corrigendum: Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin (Human Molecular Genetics (1999) 8 (397-407)) Human Molecular Genetics. 8: 943. |
0.519 |
|
| 1998 |
Wong PC, Borchelt DR, Lee MK, Pardo CA, Thinakaran G, Martin LJ, Sisodia SS, Price DL. Familial amyotrophic lateral sclerosis and Alzheimer's disease. Transgenic models. Advances in Experimental Medicine and Biology. 446: 145-59. PMID 10079842 DOI: 10.1007/978-1-4615-4869-0_9 |
0.576 |
|
| 1998 |
Price DL, Tanzi RE, Borchelt DR, Sisodia SS. Alzheimer's disease: genetic studies and transgenic models. Annual Review of Genetics. 32: 461-93. PMID 9928488 DOI: 10.1146/Annurev.Genet.32.1.461 |
0.583 |
|
| 1998 |
Pasinelli P, Borchelt DR, Houseweart MK, Cleveland DW, Brown RH. Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase. Proceedings of the National Academy of Sciences of the United States of America. 95: 15763-8. PMID 9861044 DOI: 10.1073/Pnas.95.26.15763 |
0.376 |
|
| 1998 |
Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron. 21: 1213-21. PMID 9856475 DOI: 10.1016/S0896-6273(00)80637-6 |
0.519 |
|
| 1998 |
Price DL, Sisodia SS, Borchelt DR. Genetic neurodegenerative diseases: the human illness and transgenic models. Science (New York, N.Y.). 282: 1079-83. PMID 9804539 DOI: 10.1126/Science.282.5391.1079 |
0.541 |
|
| 1998 |
Borchelt DR, Wong PC, Sisodia SS, Price DL. Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis. Brain Pathology (Zurich, Switzerland). 8: 735-57. PMID 9804381 DOI: 10.1111/J.1750-3639.1998.Tb00198.X |
0.592 |
|
| 1998 |
Borchelt DR, Wong PC, Becher MW, Pardo CA, Lee MK, Xu ZS, Thinakaran G, Jenkins NA, Copeland NG, Sisodia SS, Cleveland DW, Price DL, Hoffman PN. Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice. Neurobiology of Disease. 5: 27-35. PMID 9702785 DOI: 10.1006/Nbdi.1998.0178 |
0.523 |
|
| 1998 |
Price DL, Sisodia SS, Borchelt DR. Alzheimer disease--when and why? Nature Genetics. 19: 314-6. PMID 9697686 DOI: 10.1038/1196 |
0.517 |
|
| 1998 |
Thinakaran G, Regard JB, Bouton CM, Harris CL, Price DL, Borchelt DR, Sisodia SS. Stable association of presenilin derivatives and absence of presenilin interactions with APP. Neurobiology of Disease. 4: 438-53. PMID 9666482 DOI: 10.1006/Nbdi.1998.0171 |
0.556 |
|
| 1998 |
Borchelt DR. Metabolism of presenilin 1: influence of presenilin 1 on amyloid precursor protein processing. Neurobiology of Aging. 19: S15-8. PMID 9562461 DOI: 10.1016/S0197-4580(98)00026-8 |
0.529 |
|
| 1998 |
Davis JA, Naruse S, Chen H, Eckman C, Younkin S, Price DL, Borchelt DR, Sisodia SS, Wong PC. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos. Neuron. 20: 603-9. PMID 9539132 DOI: 10.1016/S0896-6273(00)80998-8 |
0.605 |
|
| 1998 |
Cooper JK, Schilling G, Peters MF, Herring WJ, Sharp AH, Kaminsky Z, Masone J, Khan FA, Delanoy M, Borchelt DR, Dawson VL, Dawson TM, Ross CA. Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture. Human Molecular Genetics. 7: 783-90. PMID 9536081 DOI: 10.1093/Hmg/7.5.783 |
0.41 |
|
| 1997 |
Price DL, Wong PC, Borchelt DR, Pardo CA, Thinakaran G, Doan AP, Lee MK, Martin LJ, Sisodia SS. Amyotrophic lateral sclerosis and Alzheimer disease. Lessons from model systems. Revue Neurologique. 153: 484-95. PMID 9683997 |
0.555 |
|
| 1997 |
Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron. 19: 939-45. PMID 9354339 DOI: 10.1016/S0896-6273(00)80974-5 |
0.633 |
|
| 1997 |
Thinakaran G, Harris CL, Ratovitski T, Davenport F, Slunt HH, Price DL, Borchelt DR, Sisodia SS. Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors. The Journal of Biological Chemistry. 272: 28415-22. PMID 9353300 DOI: 10.1074/Jbc.272.45.28415 |
0.564 |
|
| 1997 |
Ratovitski T, Slunt HH, Thinakaran G, Price DL, Sisodia SS, Borchelt DR. Endoproteolytic processing and stabilization of wild-type and mutant presenilin. The Journal of Biological Chemistry. 272: 24536-41. PMID 9305918 DOI: 10.1074/Jbc.272.39.24536 |
0.541 |
|
| 1997 |
Carlson GA, Borchelt DR, Dake A, Turner S, Danielson V, Coffin JD, Eckman C, Meiners J, Nilsen SP, Younkin SG, Hsiao KK. Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice. Human Molecular Genetics. 6: 1951-9. PMID 9302276 DOI: 10.1093/Hmg/6.11.1951 |
0.496 |
|
| 1997 |
Lee MK, Borchelt DR, Kim G, Thinakaran G, Slunt HH, Ratovitski T, Martin LJ, Kittur A, Gandy S, Levey AI, Jenkins N, Copeland N, Price DL, Sisodia SS. Hyperaccumulation of FAD-linked presenilin 1 variants in vivo. Nature Medicine. 3: 756-60. PMID 9212102 DOI: 10.1038/Nm0797-756 |
0.609 |
|
| 1997 |
Bruijn LI, Becher MW, Lee MK, Anderson KL, Jenkins NA, Copeland NG, Sisodia SS, Rothstein JD, Borchelt DR, Price DL, Cleveland DW. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron. 18: 327-38. PMID 9052802 DOI: 10.1016/S0896-6273(00)80272-X |
0.563 |
|
| 1996 |
Price DL, Borchelt DR, Wong PC, Pardo CA, Thinakaran G, Lee MK, Cleveland DW, Sisodia SS. Neurodegenerative diseases and model systems. Cold Spring Harbor Symposia On Quantitative Biology. 61: 725-38. PMID 9246498 DOI: 10.1101/Sqb.1996.061.01.072 |
0.471 |
|
| 1996 |
Borchelt DR, Davis J, Fischer M, Lee MK, Slunt HH, Ratovitsky T, Regard J, Copeland NG, Jenkins NA, Sisodia SS, Price DL. A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genetic Analysis : Biomolecular Engineering. 13: 159-63. PMID 9117892 DOI: 10.1016/S1050-3862(96)00167-2 |
0.582 |
|
| 1996 |
Price DL, Becher MW, Wong PC, Borchelt DR, Lee MK, Sisodia SS. Inherited neurodegenerative diseases and transgenic models. Brain Pathology (Zurich, Switzerland). 6: 467-80. PMID 8944317 DOI: 10.1111/J.1750-3639.1996.Tb00876.X |
0.557 |
|
| 1996 |
Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M, Selkoe DJ, Seeger M, Gandy SE, Price DL, Sisodia SS. Protein topology of presenilin 1. Neuron. 17: 1023-30. PMID 8938133 DOI: 10.1016/S0896-6273(00)80232-9 |
0.518 |
|
| 1996 |
Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 17: 1005-13. PMID 8938131 DOI: 10.1016/S0896-6273(00)80230-5 |
0.62 |
|
| 1996 |
Lee MK, Borchelt DR, Wong PC, Sisodia SS, Price DL. Transgenic models of neurodegenerative diseases. Current Opinion in Neurobiology. 6: 651-60. PMID 8937830 DOI: 10.1016/S0959-4388(96)80099-7 |
0.566 |
|
| 1996 |
Price DL, Koliatsos VE, Wong PC, Pardo CA, Borchelt DR, Lee MK, Cleveland DW, Griffin JW, Hoffman PN, Cork LC, Sisodia SS. Motor neuron disease and model systems: aetiologies, mechanisms and therapies. Ciba Foundation Symposium. 196: 3-13; discussion 13-. PMID 8866125 |
0.505 |
|
| 1996 |
Cleveland DW, Bruijn LI, Wong PC, Marszalek JR, Vechio JD, Lee MK, Xu XS, Borchelt DR, Sisodia SS, Price DL. Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease. Neurology. 47: S54-61; discussion S. PMID 8858052 DOI: 10.1212/Wnl.47.4_Suppl_2.54S |
0.566 |
|
| 1996 |
Borchelt DR, Sisodia SS. Loss of functional prion protein: a role in prion disorders? Chemistry & Biology. 3: 619-21. PMID 8807894 DOI: 10.1016/S1074-5521(96)90128-3 |
0.375 |
|
| 1996 |
Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE, Jenkins NA, Copeland NG, et al. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 17: 181-90. PMID 8755489 DOI: 10.1016/S0896-6273(00)80291-3 |
0.568 |
|
| 1996 |
Price D, Borchelt D, Lee M, Wong P, Martin L, Sisodia S. 631 Neurodegenerative Diseases and Model Systems Neurobiology of Aging. 17: S157. DOI: 10.1016/S0197-4580(96)80633-6 |
0.471 |
|
| 1996 |
Sisodia S, Thinakaran G, Teplow D, Siman R, Savage M, Greenberg B, Lamb B, Wang R, Price D, Borchelt D. 173 Cellular sites of APP processing and all production Neurobiology of Aging. 17: S44. DOI: 10.1016/S0197-4580(96)80175-8 |
0.421 |
|
| 1996 |
Borchelt D, Lee M, Thinakaran G, Wong PC, Slunt HHHH, Ratovitski T, Kim G, Jenkins NA, Copeland NG, Price D. 95 Synthesis and metabolism of presenilin 1 with mutations linked to familial Alzheimer's disease in transgenic mice Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80097-2 |
0.563 |
|
| 1996 |
Wong PC, Borchelt DR, Lee MK, Pardo CA, Sisodia SS, Cleveland DW, Koliatsos VE, Price DL. Transgenic and gene-targeting approaches to model disorders of motor neurons Seminars in Neuroscience. 8: 163-169. DOI: 10.1006/Smns.1996.0021 |
0.543 |
|
| 1995 |
Pardo CA, Xu Z, Borchelt DR, Price DL, Sisodia SS, Cleveland DW. Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. Proceedings of the National Academy of Sciences of the United States of America. 92: 954-8. PMID 7862672 DOI: 10.1073/Pnas.92.4.954 |
0.491 |
|
| 1995 |
Borchelt DR, Guarnieri M, Wong PC, Lee MK, Slunt HS, Xu ZS, Sisodia SS, Price DL, Cleveland DW. Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function. The Journal of Biological Chemistry. 270: 3234-8. PMID 7852409 DOI: 10.1074/Jbc.270.7.3234 |
0.515 |
|
| 1995 |
Sisodia SS, Martin LJ, Walker LC, Borchelt DR, Price DL. Cellular and molecular biology of Alzheimer's disease and animal models. Neuroimaging Clinics of North America. 5: 59-68. PMID 7743085 |
0.515 |
|
| 1995 |
Rabizadeh S, Gralla EB, Borchelt DR, Gwinn R, Valentine JS, Sisodia S, Wong P, Lee M, Hahn H, Bredesen DE. Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proceedings of the National Academy of Sciences of the United States of America. 92: 3024-8. PMID 7708768 DOI: 10.1073/Pnas.92.7.3024 |
0.345 |
|
| 1995 |
Wong PC, Pardo CA, Borchelt DR, Lee MK, Copeland NG, Jenkins NA, Sisodia SS, Cleveland DW, Price DL. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron. 14: 1105-16. PMID 7605627 DOI: 10.1016/0896-6273(95)90259-7 |
0.585 |
|
| 1995 |
Wong PC, Borchelt DR. Motor neuron disease caused by mutations in superoxide dismutase 1. Current Opinion in Neurology. 8: 294-301. PMID 7582045 DOI: 10.1097/00019052-199508000-00008 |
0.405 |
|
| 1995 |
Hsiao KK, Borchelt DR, Olson K, Johannsdottir R, Kitt C, Yunis W, Xu S, Eckman C, Younkin S, Price D. Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron. 15: 1203-18. PMID 7576662 DOI: 10.1016/0896-6273(95)90107-8 |
0.605 |
|
| 1994 |
Borchelt DR, Lee MK, Slunt HS, Guarnieri M, Xu ZS, Wong PC, Brown RH, Price DL, Sisodia SS, Cleveland DW. Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proceedings of the National Academy of Sciences of the United States of America. 91: 8292-6. PMID 8058797 DOI: 10.1073/Pnas.91.17.8292 |
0.503 |
|
| 1994 |
Borchelt DR, Koliatsos VE, Guarnieri M, Pardo CA, Sisodia SS, Price DL. Rapid anterograde axonal transport of the cellular prion glycoprotein in the peripheral and central nervous systems. The Journal of Biological Chemistry. 269: 14711-4. PMID 7514179 |
0.4 |
|
| 1993 |
Price DL, Borchelt DR, Sisodia SS. Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses. Proceedings of the National Academy of Sciences of the United States of America. 90: 6381-4. PMID 8101988 DOI: 10.1073/Pnas.90.14.6381 |
0.551 |
|
| 1993 |
Borchelt DR, Rogers M, Stahl N, Telling G, Prusiner SB. Release of the cellular prion protein from cultured cells after loss of its glycoinositol phospholipid anchor. Glycobiology. 3: 319-29. PMID 7691278 DOI: 10.1093/Glycob/3.4.319 |
0.743 |
|
| 1993 |
Price DL, Borchelt DR, Sisodia SS. Corrections: Alzheimer Disease and the Prion Disorders Amyloid β- Protein Amyloidoses Proceedings of the National Academy of Sciences of the United States of America. 90: 9233. DOI: 10.1073/Pnas.90.19.9233D |
0.527 |
|
| 1992 |
Price DL, Borchelt DR, Walker LC, Sisodia SS. Toxicity of synthetic A beta peptides and modeling of Alzheimer's disease. Neurobiology of Aging. 13: 623-5. PMID 1461354 DOI: 10.1016/0197-4580(92)90069-A |
0.499 |
|
| 1992 |
Taraboulos A, Raeber AJ, Borchelt DR, Serban D, Prusiner SB. Synthesis and trafficking of prion proteins in cultured cells. Molecular Biology of the Cell. 3: 851-63. PMID 1356522 DOI: 10.1091/Mbc.3.8.851 |
0.494 |
|
| 1992 |
Raeber AJ, Borchelt DR, Scott M, Prusiner SB. Attempts to convert the cellular prion protein into the scrapie isoform in cell-free systems. Journal of Virology. 66: 6155-63. PMID 1356161 DOI: 10.1128/Jvi.66.10.6155-6163.1992 |
0.514 |
|
| 1992 |
Borchelt DR, Taraboulos A, Prusiner SB. Evidence for synthesis of scrapie prion proteins in the endocytic pathway. The Journal of Biological Chemistry. 267: 16188-99. PMID 1353761 |
0.416 |
|
| 1990 |
Taraboulos A, Rogers M, Borchelt DR, McKinley MP, Scott M, Serban D, Prusiner SB. Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation. Proceedings of the National Academy of Sciences of the United States of America. 87: 8262-6. PMID 1978322 DOI: 10.1073/Pnas.87.21.8262 |
0.47 |
|
| 1990 |
Stahl N, Borchelt DR, Prusiner SB. Differential release of cellular and scrapie prion proteins from cellular membranes by phosphatidylinositol-specific phospholipase C. Biochemistry. 29: 5405-12. PMID 1974460 DOI: 10.1021/Bi00474A028 |
0.677 |
|
| 1990 |
Borchelt DR, Scott M, Taraboulos A, Stahl N, Prusiner SB. Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells. The Journal of Cell Biology. 110: 743-52. PMID 1968466 DOI: 10.1083/Jcb.110.3.743 |
0.49 |
|
| 1990 |
Borchelt DR, Scott M, Taraboulos A, Stahl N, Prusiner SB. Scrapie And Cellular Prion Proteins Differ In Their Kinetics Of Synthesis And Topology In Cultured Cells: 150 Journal of Neuropathology and Experimental Neurology. 49: 311. DOI: 10.1097/00005072-199005000-00156 |
0.457 |
|
| 1989 |
Borchelt DR, Perdue ML. Inhibition of avian retrovirus protein synthesis in the presence of host cellular mRNA. Archives of Virology. 107: 261-71. PMID 2554857 DOI: 10.1007/Bf01317922 |
0.544 |
|
| 1988 |
Butler DA, Scott MR, Bockman JM, Borchelt DR, Taraboulos A, Hsiao KK, Kingsbury DT, Prusiner SB. Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins. Journal of Virology. 62: 1558-64. PMID 3282080 DOI: 10.1128/Jvi.62.5.1558-1564.1988 |
0.512 |
|
| 1988 |
Borchelt D, Perdue ML. Identification of an initial site of interaction and possible helix destabilizing activity preceding initiation of protein synthesis from retrovirus RNA Virus Research. 10: 241-248. PMID 2842973 DOI: 10.1016/0168-1702(88)90019-6 |
0.542 |
|
| 1987 |
Stahl N, Borchelt DR, Hsiao K, Prusiner SB. Scrapie prion protein contains a phosphatidylinositol glycolipid. Cell. 51: 229-40. PMID 2444340 DOI: 10.1016/0092-8674(87)90150-4 |
0.671 |
|
| 1985 |
Borchelt D, Perdue ML. Influence of base-pairing in the leader region on in vitro translation of Rous sarcoma virus RNA Virus Research. 3: 141-151. PMID 2998116 DOI: 10.1016/0168-1702(85)90004-8 |
0.546 |
|
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