| Year |
Citation |
Score |
| 2021 |
Lin M, Roth RA, Kozel BA, Mecham RP, Halabi CM. Loss of Angiotensin II Type 2 Receptor Improves Blood Pressure in Elastin Insufficiency. Frontiers in Cardiovascular Medicine. 8: 782138. PMID 34790711 DOI: 10.3389/fcvm.2021.782138 |
0.597 |
|
| 2021 |
Troia A, Knutsen RH, Halabi CM, Malide D, Yu ZX, Wardlaw-Pickett A, Kronquist EK, Tsang KM, Kovacs A, Mecham RP, Kozel BA. Inhibition of NOX1 Mitigates Blood Pressure Increases in Elastin Insufficiency. Function (Oxford, England). 2: zqab015. PMID 34223172 DOI: 10.1093/function/zqab015 |
0.614 |
|
| 2020 |
Sajeesh S, Broekelman T, Mecham RP, Ramamurthi A. Stem Cell Derived Extracellular Vesicles for Vascular Elastic Matrix Regenerative Repair. Acta Biomaterialia. PMID 32645438 DOI: 10.1016/J.Actbio.2020.07.002 |
0.333 |
|
| 2020 |
Parrish PCR, Liu D, Knutsen RH, Billington CJ, Mecham RP, Fu YP, Kozel BA. Whole exome sequencing in patients with Williams-Beuren syndrome followed by disease modeling in mice points to four novel pathways that may modify stenosis risk. Human Molecular Genetics. PMID 32412588 DOI: 10.1093/Hmg/Ddaa093 |
0.64 |
|
| 2020 |
Broekelmann TJ, Bodmer NK, Mecham RP. Identification of the growth factor binding sequence in the extracellular matrix protein MAGP-1. The Journal of Biological Chemistry. PMID 31988245 DOI: 10.1074/Jbc.Ra119.010540 |
0.376 |
|
| 2020 |
Dahal S, Swaminathan G, Carney S, Broekelmann T, Mecham R, Ramamurthi A. Pro-elastogenic Effects of Mesenchymal Stem Cell Derived Smooth Muscle Cells in a 3D Collagenous Milieu. Acta Biomaterialia. PMID 31982591 DOI: 10.1016/J.Actbio.2020.01.030 |
0.342 |
|
| 2019 |
Kozel BA, Mecham RP. Elastic Fiber Ultrastructure and Assembly. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 31669522 DOI: 10.1016/J.Matbio.2019.10.002 |
0.657 |
|
| 2019 |
Lin CJ, Staiculescu MC, Hawes JZ, Cocciolone AJ, Hunkins BM, Roth RA, Lin CY, Mecham R, Wagenseil JE. Heterogeneous Cellular Contributions to Elastic Laminae Formation in Arterial Wall Development. Circulation Research. PMID 31590613 DOI: 10.1161/Circresaha.119.315348 |
0.334 |
|
| 2019 |
Li P, Halabi CM, Stewart R, Butler A, Brown B, Xia X, Santi C, England S, Ferreira J, Mecham RP, Salkoff L. Sodium-activated potassium channels moderate excitability in vascular smooth muscle. The Journal of Physiology. PMID 31444905 DOI: 10.1113/Jp278279 |
0.305 |
|
| 2019 |
Kim J, Cocciolone AJ, Staiculescu MC, Mecham RP, Wagenseil JE. Captopril treatment during development alleviates mechanically induced aortic remodeling in newborn elastin knockout mice. Biomechanics and Modeling in Mechanobiology. PMID 31270728 DOI: 10.1007/S10237-019-01198-2 |
0.311 |
|
| 2019 |
Lee VS, Halabi CM, Broekelmann TJ, Trackman PC, Stitziel NO, Mecham RP. Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress. Jci Insight. 5. PMID 31211696 DOI: 10.1172/Jci.Insight.127748 |
0.332 |
|
| 2018 |
Huang LH, Zinselmeyer BH, Chang CH, Saunders BT, Elvington A, Baba O, Broekelmann TJ, Qi L, Rueve JS, Swartz MA, Kim BS, Mecham RP, Wiig H, Thomas MJ, Sorci-Thomas MG, et al. Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis. Cell Metabolism. PMID 30415924 DOI: 10.1016/J.Cmet.2018.10.006 |
0.304 |
|
| 2018 |
Villain G, Lelievre E, Broekelmann T, Gayet O, Havet C, Werkmeister E, Mecham R, Dusetti N, Soncin F, Mattot V. MAGP-1 and Fibronectin control EGFL7 functions by driving its deposition into distinct endothelial extracellular matrix locations. The Febs Journal. PMID 30338930 DOI: 10.1111/Febs.14680 |
0.352 |
|
| 2018 |
Huang Y, McClenaghan C, Harter TM, Hinman K, Halabi CM, Matkovich SJ, Zhang H, Brown GS, Mecham RP, England SK, Kovacs A, Remedi MS, Nichols CG. Cardiovascular consequences of KATP overactivity in Cantu syndrome. Jci Insight. 3. PMID 30089727 DOI: 10.1172/Jci.Insight.121153 |
0.308 |
|
| 2018 |
Mecham RP, Ramirez F. Extracellular Determinants of Arterial Morphogenesis, Growth, and Homeostasis. Current Topics in Developmental Biology. 130: 193-216. PMID 29853177 DOI: 10.1016/Bs.Ctdb.2018.02.001 |
0.341 |
|
| 2018 |
Luo Y, Li N, Chen H, Fernandez GE, Warburton D, Moats R, Mecham RP, Krenitsky D, Pryhuber GS, Shi W. Spatial and temporal changes in extracellular elastin and laminin distribution during lung alveolar development. Scientific Reports. 8: 8334. PMID 29844468 DOI: 10.1038/S41598-018-26673-1 |
0.342 |
|
| 2018 |
Craft CS, Broekelmann TJ, Mecham RP. Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 29524629 DOI: 10.1016/J.Matbio.2018.03.006 |
0.363 |
|
| 2018 |
Mecham RP. Elastin in lung development and disease pathogenesis. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 29331337 DOI: 10.1016/J.Matbio.2018.01.005 |
0.387 |
|
| 2018 |
Halabi CM, Mecham RP. Elastin purification and solubilization. Methods in Cell Biology. 143: 207-222. PMID 29310779 DOI: 10.1016/Bs.Mcb.2017.08.012 |
0.342 |
|
| 2018 |
Stoilov I, Starcher BC, Mecham RP, Broekelmann TJ. Measurement of elastin, collagen, and total protein levels in tissues. Methods in Cell Biology. 143: 133-146. PMID 29310774 DOI: 10.1016/Bs.Mcb.2017.08.008 |
0.324 |
|
| 2017 |
Dahal S, Broekelmann T, Mecham R, Ramamurthi A. Maintaining elastogenicity of mesenchymal stem cell derived smooth muscle cells in 2D culture. Tissue Engineering. Part A. PMID 29264957 DOI: 10.1089/Ten.Tea.2017.0237 |
0.351 |
|
| 2017 |
Li R, Herriges JC, Chen L, Mecham RP, Sun X. FGF receptors control alveolar elastogenesis. Development (Cambridge, England). PMID 29122839 DOI: 10.1242/Dev.149443 |
0.324 |
|
| 2017 |
Eekhoff JD, Fang F, Kahan LG, Espinosa MG, Cocciolone AJ, Wagenseil JE, Mecham RP, Lake SP. Functionally Distinct Tendons from Elastin Haploinsufficient Mice Exhibit Mild Stiffening and Tendon-Specific Structural Alteration. Journal of Biomechanical Engineering. PMID 28916838 DOI: 10.1115/1.4037932 |
0.363 |
|
| 2017 |
Camardo A, Seshadri D, Broekelmann T, Mecham R, Ramamurthi A. Multifunctional, JNK-inhibiting nanotherapeutics for augmented elastic matrix regenerative repair in aortic aneurysms. Drug Delivery and Translational Research. PMID 28875468 DOI: 10.1007/S13346-017-0419-Y |
0.33 |
|
| 2017 |
Kim J, Staiculescu MC, Cocciolone AJ, Yanagisawa H, Mecham RP, Wagenseil JE. Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta. Journal of Biomechanics. PMID 28778385 DOI: 10.1016/J.Jbiomech.2017.07.011 |
0.359 |
|
| 2017 |
Staiculescu MC, Kim J, Mecham RP, Wagenseil J. Mechanical behavior and matrisome gene expression in aneurysm-prone thoracic aorta of newborn lysyl oxidase knockout mice. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00712.2016. PMID 28550176 DOI: 10.1152/Ajpheart.00712.2016 |
0.361 |
|
| 2017 |
Halabi CM, Broekelmann TJ, Lin M, Lee VS, Chu ML, Mecham RP. Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries. Science Advances. 3: e1602532. PMID 28508064 DOI: 10.1126/Sciadv.1602532 |
0.381 |
|
| 2017 |
Munjal C, Jegga AG, Opoka AM, Stoilov I, Norris RA, Thomas CJ, Smith JM, Mecham RP, Bressan GM, Hinton RB. Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model. Physiological Reports. 5. PMID 28270590 DOI: 10.14814/Phy2.13152 |
0.316 |
|
| 2017 |
Jiao Y, Li G, Korneva A, Caulk AW, Qin L, Bersi MR, Li Q, Li W, Mecham RP, Humphrey JD, Tellides G. Deficient Circumferential Growth Is the Primary Determinant of Aortic Obstruction Attributable to Partial Elastin Deficiency. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 28254817 DOI: 10.1161/Atvbaha.117.309079 |
0.309 |
|
| 2016 |
Swaminathan G, Stoilov I, Broekelmann T, Mecham R, Ramamurthi A. Phenotype-Based Selection of Bone Marrow Mesenchymal Stem Cell-Derived Smooth Muscle Cells for Elastic Matrix Regenerative Repair in Abdominal Aortic Aneurysms. Journal of Tissue Engineering and Regenerative Medicine. PMID 27860330 DOI: 10.1002/Term.2349 |
0.329 |
|
| 2016 |
Ferruzzi J, Bersi MR, Mecham RP, Ramirez F, Yanagisawa H, Tellides G, Humphrey JD. Loss of Elastic Fiber Integrity Compromises Common Carotid Artery Function: Implications for Vascular Aging. Artery Research. 14: 41-52. PMID 27570569 DOI: 10.1016/J.Artres.2016.04.001 |
0.345 |
|
| 2016 |
Lee VS, Halabi CM, Hoffman EP, Carmichael N, Leshchiner I, Lian CG, Bierhals AJ, Vuzman D, Mecham RP, Frank NY, Stitziel NO. Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans. Proceedings of the National Academy of Sciences of the United States of America. PMID 27432961 DOI: 10.1073/Pnas.1601442113 |
0.312 |
|
| 2016 |
Balestrini JL, Gard AL, Gerhold KA, Wilcox EC, Liu A, Schwan J, Le AV, Baevova P, Dimitrievska S, Zhao L, Sundaram S, Sun H, Rittié L, Dyal R, Broekelmann TJ, ... Mecham RP, et al. Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine. Biomaterials. 102: 220-230. PMID 27344365 DOI: 10.1016/J.Biomaterials.2016.06.025 |
0.322 |
|
| 2016 |
Walji TA, Turecamo SE, DeMarsilis AJ, Sakai LY, Mecham RP, Craft CS. Characterization of metabolic health in mouse models of fibrillin-1 perturbation. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 26902431 DOI: 10.1016/J.Matbio.2016.02.006 |
0.31 |
|
| 2015 |
Halabi CM, Broekelmann TJ, Knutsen RH, Ye L, Mecham RP, Kozel BA. Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness. American Journal of Physiology. Heart and Circulatory Physiology. 309: H1008-16. PMID 26232234 DOI: 10.1152/Ajpheart.00288.2015 |
0.629 |
|
| 2015 |
Igoucheva O, Alexeev V, Halabi CM, Adams SM, Stoilov I, Sasaki T, Arita M, Donahue A, Mecham RP, Birk DE, Chu ML. Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities. The Journal of Biological Chemistry. 290: 21443-59. PMID 26178373 DOI: 10.1074/Jbc.M115.640425 |
0.4 |
|
| 2015 |
Mecham RP, Gibson MA. The microfibril-associated glycoproteins (MAGPs) and the microfibrillar niche. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 25963142 DOI: 10.1016/J.Matbio.2015.05.003 |
0.432 |
|
| 2015 |
Hubmacher D, Wang LW, Mecham RP, Reinhardt DP, Apte SS. Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia. Disease Models & Mechanisms. 8: 487-99. PMID 25762570 DOI: 10.1242/Dmm.017046 |
0.396 |
|
| 2015 |
Le VP, Cheng JK, Kim J, Staiculescu MC, Ficker SW, Sheth SC, Bhayani SA, Mecham RP, Yanagisawa H, Wagenseil JE. Mechanical factors direct mouse aortic remodelling during early maturation. Journal of the Royal Society, Interface / the Royal Society. 12: 20141350. PMID 25652465 DOI: 10.1098/Rsif.2014.1350 |
0.348 |
|
| 2014 |
DeMarsilis AJ, Walji TA, Maedeker JA, Stoka KV, Kozel BA, Mecham RP, Wagenseil JE, Craft CS. Elastin Insufficiency Predisposes Mice to Impaired Glucose Metabolism. Journal of Molecular and Genetic Medicine : An International Journal of Biomedical Research. 8. PMID 26167199 DOI: 10.4172/1747-0862.1000129 |
0.638 |
|
| 2014 |
Swaminathan G, Gadepalli VS, Stoilov I, Mecham RP, Rao RR, Ramamurthi A. Pro-elastogenic effects of bone marrow mesenchymal stem cell-derived smooth muscle cells on cultured aneurysmal smooth muscle cells. Journal of Tissue Engineering and Regenerative Medicine. PMID 25376929 DOI: 10.1002/Term.1964 |
0.322 |
|
| 2014 |
Osei-Owusu P, Knutsen RH, Kozel BA, Dietrich HH, Blumer KJ, Mecham RP. Altered reactivity of resistance vasculature contributes to hypertension in elastin insufficiency. American Journal of Physiology. Heart and Circulatory Physiology. 306: H654-66. PMID 24414067 DOI: 10.1152/Ajpheart.00601.2013 |
0.632 |
|
| 2013 |
Beene LC, Wang LW, Hubmacher D, Keene DR, Reinhardt DP, Annis DS, Mosher DF, Mecham RP, Traboulsi EI, Apte SS. Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome. Investigative Ophthalmology & Visual Science. 54: 8337-44. PMID 24265020 DOI: 10.1167/Iovs.13-13121 |
0.34 |
|
| 2013 |
Li A, Knutsen RH, Zhang H, Osei-Owusu P, Moreno-Dominguez A, Harter TM, Uchida K, Remedi MS, Dietrich HH, Bernal-Mizrachi C, Blumer KJ, Mecham RP, Koster JC, Nichols CG. Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle. Journal of the American Heart Association. 2: e000365. PMID 23974906 DOI: 10.1161/Jaha.113.000365 |
0.317 |
|
| 2013 |
Combs MD, Knutsen RH, Broekelmann TJ, Toennies HM, Brett TJ, Miller CA, Kober DL, Craft CS, Atkinson JJ, Shipley JM, Trask BC, Mecham RP. Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo. The Journal of Biological Chemistry. 288: 28869-80. PMID 23963447 DOI: 10.1074/Jbc.M113.497727 |
0.371 |
|
| 2013 |
Cheng JK, Stoilov I, Mecham RP, Wagenseil JE. A fiber-based constitutive model predicts changes in amount and organization of matrix proteins with development and disease in the mouse aorta. Biomechanics and Modeling in Mechanobiology. 12: 497-510. PMID 22790326 DOI: 10.1007/S10237-012-0420-9 |
0.389 |
|
| 2012 |
Zou W, Deselm CJ, Broekelmann TJ, Mecham RP, Vande Pol S, Choi K, Teitelbaum SL. Paxillin contracts the osteoclast cytoskeleton. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 27: 2490-500. PMID 22807029 DOI: 10.1002/Jbmr.1706 |
0.316 |
|
| 2012 |
Sugitani H, Hirano E, Knutsen RH, Shifren A, Wagenseil JE, Ciliberto C, Kozel BA, Urban Z, Davis EC, Broekelmann TJ, Mecham RP. Alternative splicing and tissue-specific elastin misassembly act as biological modifiers of human elastin gene frameshift mutations associated with dominant cutis laxa. The Journal of Biological Chemistry. 287: 22055-67. PMID 22573328 DOI: 10.1074/Jbc.M111.327940 |
0.681 |
|
| 2012 |
Wagenseil JE, Mecham RP. Elastin in large artery stiffness and hypertension. Journal of Cardiovascular Translational Research. 5: 264-73. PMID 22290157 DOI: 10.1007/S12265-012-9349-8 |
0.351 |
|
| 2011 |
Kozel BA, Knutsen RH, Ye L, Ciliberto CH, Broekelmann TJ, Mecham RP. Genetic modifiers of cardiovascular phenotype caused by elastin haploinsufficiency act by extrinsic noncomplementation. The Journal of Biological Chemistry. 286: 44926-36. PMID 22049077 DOI: 10.1074/Jbc.M111.274779 |
0.649 |
|
| 2011 |
Baldo G, Wu S, Howe RA, Ramamoothy M, Knutsen RH, Fang J, Mecham RP, Liu Y, Wu X, Atkinson JP, Ponder KP. Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation. Molecular Genetics and Metabolism. 104: 608-19. PMID 21944884 DOI: 10.1016/J.Ymgme.2011.08.018 |
0.316 |
|
| 2011 |
Hidalgo-Tamola J, Luttrell I, Jiang X, Li D, Mecham RP, Chitaley K. Characterization of erectile function in elastin haploinsufficicent mice. The Journal of Sexual Medicine. 8: 3075-85. PMID 21883953 DOI: 10.1111/J.1743-6109.2011.02454.X |
0.337 |
|
| 2011 |
Akhtar K, Broekelmann TJ, Song H, Turk J, Brett TJ, Mecham RP, Adair-Kirk TL. Oxidative modifications of the C-terminal domain of tropoelastin prevent cell binding. The Journal of Biological Chemistry. 286: 13574-82. PMID 21321118 DOI: 10.1074/Jbc.M110.192088 |
0.352 |
|
| 2011 |
Callewaert B, Renard M, Hucthagowder V, Albrecht B, Hausser I, Blair E, Dias C, Albino A, Wachi H, Sato F, Mecham RP, Loeys B, Coucke PJ, De Paepe A, Urban Z. New insights into the pathogenesis of autosomal-dominant cutis laxa with report of five ELN mutations. Human Mutation. 32: 445-55. PMID 21309044 DOI: 10.1002/Humu.21462 |
0.325 |
|
| 2011 |
Watts CR, Knutsen RH, Ciliberto C, Mecham RP. Evidence for heterozygous abnormalities of the elastin gene (ELN) affecting the quantity of vocal fold elastic fibers: a pilot study. Journal of Voice : Official Journal of the Voice Foundation. 25: e85-90. PMID 20926252 DOI: 10.1016/J.Jvoice.2010.04.006 |
0.319 |
|
| 2011 |
Yuan L, Holmes TC, Watts RE, Khosla C, Broekelmann TJ, Mecham R, Zheng H, Izaguirre EW, Rich KM. Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomas. Journal of Neuro-Oncology. 103: 207-19. PMID 20824305 DOI: 10.1007/S11060-010-0379-2 |
0.314 |
|
| 2010 |
Akhtar K, Broekelmann TJ, Miao M, Keeley FW, Starcher BC, Pierce RA, Mecham RP, Adair-Kirk TL. Oxidative and nitrosative modifications of tropoelastin prevent elastic fiber assembly in vitro. The Journal of Biological Chemistry. 285: 37396-404. PMID 20847053 DOI: 10.1074/Jbc.M110.126789 |
0.34 |
|
| 2010 |
Weinbaum JS, Tranquillo RT, Mecham RP. The matrix-binding domain of microfibril-associated glycoprotein-1 targets active connective tissue growth factor to a fibroblast-produced extracellular matrix. Macromolecular Bioscience. 10: 1338-44. PMID 20799254 DOI: 10.1002/Mabi.201000121 |
0.374 |
|
| 2010 |
Hu Q, Shifren A, Sens C, Choi J, Szabo Z, Starcher BC, Knutsen RH, Shipley JM, Davis EC, Mecham RP, Urban Z. Mechanisms of emphysema in autosomal dominant cutis laxa. Matrix Biology : Journal of the International Society For Matrix Biology. 29: 621-8. PMID 20600892 DOI: 10.1016/J.Matbio.2010.06.005 |
0.34 |
|
| 2010 |
Hinton RB, Adelman-Brown J, Witt S, Krishnamurthy VK, Osinska H, Sakthivel B, James JF, Li DY, Narmoneva DA, Mecham RP, Benson DW. Elastin haploinsufficiency results in progressive aortic valve malformation and latent valve disease in a mouse model. Circulation Research. 107: 549-57. PMID 20576933 DOI: 10.1161/Circresaha.110.221358 |
0.304 |
|
| 2010 |
Wagenseil JE, Ciliberto CH, Knutsen RH, Levy MA, Kovacs A, Mecham RP. The importance of elastin to aortic development in mice. American Journal of Physiology. Heart and Circulatory Physiology. 299: H257-64. PMID 20495146 DOI: 10.1152/Ajpheart.00194.2010 |
0.319 |
|
| 2009 |
Carta L, Wagenseil JE, Knutsen RH, Mariko B, Faury G, Davis EC, Starcher B, Mecham RP, Ramirez F. Discrete contributions of elastic fiber components to arterial development and mechanical compliance. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 2083-9. PMID 19850904 DOI: 10.1161/Atvbaha.109.193227 |
0.34 |
|
| 2009 |
Wagenseil JE, Mecham RP. Vascular extracellular matrix and arterial mechanics. Physiological Reviews. 89: 957-89. PMID 19584318 DOI: 10.1152/Physrev.00041.2008 |
0.359 |
|
| 2009 |
Wagenseil JE, Ciliberto CH, Knutsen RH, Levy MA, Kovacs A, Mecham RP. Reduced vessel elasticity alters cardiovascular structure and function in newborn mice. Circulation Research. 104: 1217-24. PMID 19372465 DOI: 10.1161/Circresaha.108.192054 |
0.333 |
|
| 2008 |
Cirulis JT, Bellingham CM, Davis EC, Hubmacher D, Reinhardt DP, Mecham RP, Keeley FW. Fibrillins, fibulins, and matrix-associated glycoprotein modulate the kinetics and morphology of in vitro self-assembly of a recombinant elastin-like polypeptide. Biochemistry. 47: 12601-13. PMID 18973305 DOI: 10.1021/Bi8005384 |
0.341 |
|
| 2008 |
Gansner JM, Madsen EC, Mecham RP, Gitlin JD. Essential role for fibrillin-2 in zebrafish notochord and vascular morphogenesis. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 2844-61. PMID 18816837 DOI: 10.1002/Dvdy.21705 |
0.341 |
|
| 2008 |
Shifren A, Durmowicz AG, Knutsen RH, Faury G, Mecham RP. Elastin insufficiency predisposes to elevated pulmonary circulatory pressures through changes in elastic artery structure. Journal of Applied Physiology (Bethesda, Md. : 1985). 105: 1610-9. PMID 18772328 DOI: 10.1152/Japplphysiol.90563.2008 |
0.317 |
|
| 2008 |
Lammers SR, Kao PH, Qi HJ, Hunter K, Lanning C, Albietz J, Hofmeister S, Mecham R, Stenmark KR, Shandas R. Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves. American Journal of Physiology. Heart and Circulatory Physiology. 295: H1451-9. PMID 18660454 DOI: 10.1152/Ajpheart.00127.2008 |
0.32 |
|
| 2008 |
Weinbaum JS, Broekelmann TJ, Pierce RA, Werneck CC, Segade F, Craft CS, Knutsen RH, Mecham RP. Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems. The Journal of Biological Chemistry. 283: 25533-43. PMID 18625713 DOI: 10.1074/Jbc.M709962200 |
0.306 |
|
| 2008 |
Broekelmann TJ, Ciliberto CH, Shifren A, Mecham RP. Modification and functional inactivation of the tropoelastin carboxy-terminal domain in cross-linked elastin. Matrix Biology : Journal of the International Society For Matrix Biology. 27: 631-9. PMID 18602002 DOI: 10.1016/J.Matbio.2008.06.001 |
0.389 |
|
| 2008 |
Larsson E, McLean SE, Mecham RP, Lindahl P, Nelander S. Do two mutually exclusive gene modules define the phenotypic diversity of mammalian smooth muscle? Molecular Genetics and Genomics : Mgg. 280: 127-37. PMID 18509681 DOI: 10.1007/S00438-008-0349-Y |
0.307 |
|
| 2008 |
Ma X, Tittiger M, Knutsen RH, Kovacs A, Schaller L, Mecham RP, Ponder KP. Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice. Molecular Genetics and Metabolism. 94: 298-304. PMID 18479957 DOI: 10.1016/J.Ymgme.2008.03.018 |
0.368 |
|
| 2008 |
Mecham RP. Methods in elastic tissue biology: elastin isolation and purification. Methods (San Diego, Calif.). 45: 32-41. PMID 18442703 DOI: 10.1016/J.Ymeth.2008.01.007 |
0.378 |
|
| 2008 |
Werneck CC, Vicente CP, Weinberg JS, Shifren A, Pierce RA, Broekelmann TJ, Tollefsen DM, Mecham RP. Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury. Blood. 111: 4137-44. PMID 18281502 DOI: 10.1182/Blood-2007-07-101733 |
0.357 |
|
| 2008 |
Mydel P, Shipley JM, Adair-Kirk TL, Kelley DG, Broekelmann TJ, Mecham RP, Senior RM. Neutrophil elastase cleaves laminin-332 (laminin-5) generating peptides that are chemotactic for neutrophils. The Journal of Biological Chemistry. 283: 9513-22. PMID 18178964 DOI: 10.1074/Jbc.M706239200 |
0.309 |
|
| 2008 |
Pezet M, Jacob MP, Escoubet B, Gheduzzi D, Tillet E, Perret P, Huber P, Quaglino D, Vranckx R, Li DY, Starcher B, Boyle WA, Mecham RP, Faury G. Elastin haploinsufficiency induces alternative aging processes in the aorta. Rejuvenation Research. 11: 97-112. PMID 18173368 DOI: 10.1089/Rej.2007.0587 |
0.363 |
|
| 2008 |
El-Bizri N, Wang L, Merklinger SL, Guignabert C, Desai T, Urashima T, Sheikh AY, Knutsen RH, Mecham RP, Mishina Y, Rabinovitch M. Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling. Circulation Research. 102: 380-8. PMID 18079409 DOI: 10.1161/Circresaha.107.161059 |
0.335 |
|
| 2008 |
Sicot FX, Tsuda T, Markova D, Klement JF, Arita M, Zhang RZ, Pan TC, Mecham RP, Birk DE, Chu ML. Fibulin-2 is dispensable for mouse development and elastic fiber formation. Molecular and Cellular Biology. 28: 1061-7. PMID 18070922 DOI: 10.1128/Mcb.01876-07 |
0.392 |
|
| 2008 |
McGowan SE, Holmes AJ, Mecham RP, Ritty TM. Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration. American Journal of Respiratory Cell and Molecular Biology. 38: 435-45. PMID 18006876 DOI: 10.1165/Rcmb.2007-0281Oc |
0.383 |
|
| 2007 |
Wagenseil JE, Mecham RP. New insights into elastic fiber assembly. Birth Defects Research. Part C, Embryo Today : Reviews. 81: 229-40. PMID 18228265 DOI: 10.1002/Bdrc.20111 |
0.389 |
|
| 2007 |
Segade F, Suganuma N, Mychaleckyj JC, Mecham RP. The intracellular form of human MAGP1 elicits a complex and specific transcriptional response. The International Journal of Biochemistry & Cell Biology. 39: 2303-13. PMID 17692555 DOI: 10.1016/J.Biocel.2007.06.017 |
0.336 |
|
| 2007 |
Hirano E, Knutsen RH, Sugitani H, Ciliberto CH, Mecham RP. Functional rescue of elastin insufficiency in mice by the human elastin gene: implications for mouse models of human disease. Circulation Research. 101: 523-31. PMID 17626896 DOI: 10.1161/Circresaha.107.153510 |
0.335 |
|
| 2007 |
Wagenseil JE, Knutsen RH, Li DY, Mecham RP. Elastin-insufficient mice show normal cardiovascular remodeling in 2K1C hypertension despite higher baseline pressure and unique cardiovascular architecture. American Journal of Physiology. Heart and Circulatory Physiology. 293: H574-82. PMID 17400710 DOI: 10.1152/Ajpheart.00205.2007 |
0.313 |
|
| 2007 |
Lemaire R, Bayle J, Mecham RP, Lafyatis R. Microfibril-associated MAGP-2 stimulates elastic fiber assembly. The Journal of Biological Chemistry. 282: 800-8. PMID 17099216 DOI: 10.1074/Jbc.M609692200 |
0.368 |
|
| 2007 |
Wachi H, Sato F, Nakazawa J, Nonaka R, Szabo Z, Urban Z, Yasunaga T, Maeda I, Okamoto K, Starcher BC, Li DY, Mecham RP, Seyama Y. Domains 16 and 17 of tropoelastin in elastic fibre formation. The Biochemical Journal. 402: 63-70. PMID 17037986 DOI: 10.1042/Bj20061145 |
0.378 |
|
| 2006 |
Hu Q, Loeys BL, Coucke PJ, De Paepe A, Mecham RP, Choi J, Davis EC, Urban Z. Fibulin-5 mutations: mechanisms of impaired elastic fiber formation in recessive cutis laxa. Human Molecular Genetics. 15: 3379-86. PMID 17035250 DOI: 10.1093/Hmg/Ddl414 |
0.377 |
|
| 2006 |
McLaughlin PJ, Chen Q, Horiguchi M, Starcher BC, Stanton JB, Broekelmann TJ, Marmorstein AD, McKay B, Mecham R, Nakamura T, Marmorstein LY. Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice. Molecular and Cellular Biology. 26: 1700-9. PMID 16478991 DOI: 10.1128/Mcb.26.5.1700-1709.2006 |
0.4 |
|
| 2006 |
Czirok A, Zach J, Kozel BA, Mecham RP, Davis EC, Rongish BJ. Elastic fiber macro-assembly is a hierarchical, cell motion-mediated process. Journal of Cellular Physiology. 207: 97-106. PMID 16331676 DOI: 10.1002/Jcp.20573 |
0.662 |
|
| 2006 |
Kozel BA, Rongish BJ, Czirok A, Zach J, Little CD, Davis EC, Knutsen RH, Wagenseil JE, Levy MA, Mecham RP. Elastic fiber formation: a dynamic view of extracellular matrix assembly using timer reporters. Journal of Cellular Physiology. 207: 87-96. PMID 16261592 DOI: 10.1002/Jcp.20546 |
0.665 |
|
| 2006 |
Ma X, Tittiger M, Knutson R, Mecham R, Schaller L, Ponder K. 866. Aortic Disease in Mucopolysaccharidodis I Mice Is Due to Increased Expression of Matrix Metalloproteinase 12 (MMP 12) Can Be Prevented with Neonatal Retroviral Vector-Mediated Gene Therapy Molecular Therapy. 13: S333-S334. DOI: 10.1016/J.Ymthe.2006.08.954 |
0.35 |
|
| 2005 |
Segade F, Mecham RP. Regulatory elements of microfibril-associated glycoprotein-1 gene expression in muscle cells. Biochimica Et Biophysica Acta. 1731: 215-24. PMID 16321658 DOI: 10.1016/J.Bbaexp.2005.10.007 |
0.329 |
|
| 2005 |
Thomassin L, Werneck CC, Broekelmann TJ, Gleyzal C, Hornstra IK, Mecham RP, Sommer P. The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers. The Journal of Biological Chemistry. 280: 42848-55. PMID 16251195 DOI: 10.1074/Jbc.M506832200 |
0.364 |
|
| 2005 |
Broekelmann TJ, Kozel BA, Ishibashi H, Werneck CC, Keeley FW, Zhang L, Mecham RP. Tropoelastin interacts with cell-surface glycosaminoglycans via its COOH-terminal domain. The Journal of Biological Chemistry. 280: 40939-47. PMID 16192266 DOI: 10.1074/Jbc.M507309200 |
0.663 |
|
| 2005 |
Merklinger SL, Wagner RA, Spiekerkoetter E, Hinek A, Knutsen RH, Kabir MG, Desai K, Hacker S, Wang L, Cann GM, Ambartsumian NS, Lukanidin E, Bernstein D, Husain M, Mecham RP, et al. Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension. Circulation Research. 97: 596-604. PMID 16109920 DOI: 10.1161/01.Res.0000182425.49768.8A |
0.324 |
|
| 2005 |
Kelleher CM, Silverman EK, Broekelmann T, Litonjua AA, Hernandez M, Sylvia JS, Stoler J, Reilly JJ, Chapman HA, Speizer FE, Weiss ST, Mecham RP, Raby BA. A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. American Journal of Respiratory Cell and Molecular Biology. 33: 355-62. PMID 16081882 DOI: 10.1165/Rcmb.2005-0206Oc |
0.345 |
|
| 2005 |
Wagenseil JE, Nerurkar NL, Knutsen RH, Okamoto RJ, Li DY, Mecham RP. Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries. American Journal of Physiology. Heart and Circulatory Physiology. 289: H1209-17. PMID 15863465 DOI: 10.1152/Ajpheart.00046.2005 |
0.311 |
|
| 2005 |
Spencer JA, Hacker SL, Davis EC, Mecham RP, Knutsen RH, Li DY, Gerard RD, Richardson JA, Olson EN, Yanagisawa H. Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration. Proceedings of the National Academy of Sciences of the United States of America. 102: 2946-51. PMID 15710889 DOI: 10.1073/Pnas.0500058102 |
0.359 |
|
| 2005 |
Hofmann CS, Wang X, Sullivan CP, Toselli P, Stone PJ, McLean SE, Mecham RP, Schreiber BM, Sonenshein GE. B-Myb represses elastin gene expression in aortic smooth muscle cells. The Journal of Biological Chemistry. 280: 7694-701. PMID 15615710 DOI: 10.1074/Jbc.M412501200 |
0.317 |
|
| 2004 |
Kelleher CM, McLean SE, Mecham RP. Vascular extracellular matrix and aortic development. Current Topics in Developmental Biology. 62: 153-88. PMID 15522742 DOI: 10.1016/S0070-2153(04)62006-0 |
0.371 |
|
| 2004 |
Wachi H, Sugitani H, Murata H, Nakazawa J, Mecham RP, Seyama Y. Tropoelastin inhibits vascular calcification via 67-kDa elastin binding protein in cultured bovine aortic smooth muscle cells. Journal of Atherosclerosis and Thrombosis. 11: 159-66. PMID 15256767 DOI: 10.5551/Jat.11.159 |
0.359 |
|
| 2004 |
Kozel BA, Ciliberto CH, Mecham RP. Deposition of tropoelastin into the extracellular matrix requires a competent elastic fiber scaffold but not live cells. Matrix Biology : Journal of the International Society For Matrix Biology. 23: 23-34. PMID 15172035 DOI: 10.1016/J.Matbio.2004.02.004 |
0.676 |
|
| 2004 |
Zweers MC, van Vlijmen-Willems IM, van Kuppevelt TH, Mecham RP, Steijlen PM, Bristow J, Schalkwijk J. Deficiency of tenascin-X causes abnormalities in dermal elastic fiber morphology. The Journal of Investigative Dermatology. 122: 885-91. PMID 15102077 DOI: 10.1111/J.0022-202X.2004.22401.X |
0.342 |
|
| 2004 |
Werneck CC, Trask BC, Broekelmann TJ, Trask TM, Ritty TM, Segade F, Mecham RP. Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2. The Journal of Biological Chemistry. 279: 23045-51. PMID 15044481 DOI: 10.1074/Jbc.M402656200 |
0.766 |
|
| 2004 |
Fu X, Kao JL, Bergt C, Kassim SY, Huq NP, d'Avignon A, Parks WC, Mecham RP, Heinecke JW. Oxidative cross-linking of tryptophan to glycine restrains matrix metalloproteinase activity: specific structural motifs control protein oxidation. The Journal of Biological Chemistry. 279: 6209-12. PMID 14670964 DOI: 10.1074/Jbc.C300506200 |
0.323 |
|
| 2003 |
Faury G, Pezet M, Knutsen RH, Boyle WA, Heximer SP, McLean SE, Minkes RK, Blumer KJ, Kovacs A, Kelly DP, Li DY, Starcher B, Mecham RP. Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency. The Journal of Clinical Investigation. 112: 1419-28. PMID 14597767 DOI: 10.1172/Jci19028 |
0.345 |
|
| 2003 |
Ritty TM, Broekelmann TJ, Werneck CC, Mecham RP. Fibrillin-1 and -2 contain heparin-binding sites important for matrix deposition and that support cell attachment. The Biochemical Journal. 375: 425-32. PMID 12837131 DOI: 10.1042/Bj20030649 |
0.397 |
|
| 2003 |
Buján J, Gimeno MJ, Jiménez JA, Kielty CM, Mecham RP, Bellón JM. Expression of elastic components in healthy and varicose veins. World Journal of Surgery. 27: 901-5. PMID 12784143 DOI: 10.1007/S00268-003-6897-8 |
0.324 |
|
| 2003 |
Kozel BA, Wachi H, Davis EC, Mecham RP. Domains in tropoelastin that mediate elastin deposition in vitro and in vivo. The Journal of Biological Chemistry. 278: 18491-8. PMID 12626514 DOI: 10.1074/Jbc.M212715200 |
0.685 |
|
| 2003 |
Sugitani H, Wachi H, Murata H, Sato F, Mecham RP, Seyama Y. Characterization of an in vitro model of calcification in retinal pigmented epithelial cells. Journal of Atherosclerosis and Thrombosis. 10: 48-56. PMID 12621165 DOI: 10.5551/Jat.10.48 |
0.353 |
|
| 2003 |
Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. The Journal of Clinical Investigation. 111: 445-52. PMID 12588882 DOI: 10.1172/Jci15598 |
0.316 |
|
| 2003 |
Hornstra IK, Birge S, Starcher B, Bailey AJ, Mecham RP, Shapiro SD. Lysyl oxidase is required for vascular and diaphragmatic development in mice. The Journal of Biological Chemistry. 278: 14387-93. PMID 12473682 DOI: 10.1074/Jbc.M210144200 |
0.369 |
|
| 2002 |
Sugitani H, Wachi H, Mecham RP, Seyama Y. Accelerated calcification represses the expression of elastic fiber components and lysyl oxidase in cultured bovine aortic smooth muscle cells. Journal of Atherosclerosis and Thrombosis. 9: 292-8. PMID 12560590 DOI: 10.5551/Jat.9.292 |
0.339 |
|
| 2002 |
Davis EC, Roth RA, Heuser JE, Mecham RP. Ultrastructural properties of ciliary zonule microfibrils. Journal of Structural Biology. 139: 65-75. PMID 12406689 DOI: 10.1016/S1047-8477(02)00559-2 |
0.306 |
|
| 2002 |
Hill CH, Mecham R, Starcher B. Fibrillin-2 defects impair elastic fiber assembly in a homocysteinemic chick model. The Journal of Nutrition. 132: 2143-50. PMID 12163653 DOI: 10.1093/Jn/132.8.2143 |
0.332 |
|
| 2002 |
Segade F, Trask BC, Broekelmann TJ, Pierce RA, Mecham RP. Identification of a matrix-binding domain in MAGP1 and MAGP2 and intracellular localization of alternative splice forms. The Journal of Biological Chemistry. 277: 11050-7. PMID 11796718 DOI: 10.1074/Jbc.M110347200 |
0.433 |
|
| 2002 |
Fukui N, McAlinden A, Zhu Y, Crouch E, Broekelmann TJ, Mecham RP, Sandell LJ. Processing of type II procollagen amino propeptide by matrix metalloproteinases. The Journal of Biological Chemistry. 277: 2193-201. PMID 11705992 DOI: 10.1074/Jbc.M105485200 |
0.346 |
|
| 2002 |
Downer R, Roche F, Park PW, Mecham RP, Foster TJ. The elastin-binding protein of Staphylococcus aureus (EbpS) is expressed at the cell surface as an integral membrane protein and not as a cell wall-associated protein. The Journal of Biological Chemistry. 277: 243-50. PMID 11684686 DOI: 10.1074/Jbc.M107621200 |
0.357 |
|
| 2001 |
Mecham RP. Overview of extracellular matrix. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 10.1. PMID 18228295 DOI: 10.1002/0471143030.Cb1001S00 |
0.322 |
|
| 2001 |
Trask BC, Broekelmann T, Ritty TM, Trask TM, Tisdale C, Mecham RP. Posttranslational modifications of microfibril associated glycoprotein-1 (MAGP-1). Biochemistry. 40: 4372-80. PMID 11284693 DOI: 10.1021/Bi002738Z |
0.76 |
|
| 2000 |
Segade F, Broekelmann TJ, Pierce RA, Mecham RP. Revised genomic structure of the human MAGP1 gene and identification of alternate transcripts in human and mouse tissues Matrix Biology. 19: 671-682. PMID 11102756 DOI: 10.1016/S0945-053X(00)00115-3 |
0.334 |
|
| 2000 |
Dietz HC, Mecham RP. Mouse models of genetic diseases resulting from mutations in elastic fiber proteins Matrix Biology. 19: 481-488. PMID 11068202 DOI: 10.1016/S0945-053X(00)00101-3 |
0.394 |
|
| 2000 |
Shipley JM, Mecham RP, Maus E, Bonadio J, Rosenbloom J, McCarthy RT, Baumann ML, Frankfater C, Segade F, Shapiro SD. Developmental expression of latent transforming growth factor beta binding protein 2 and its requirement early in mouse development. Molecular and Cellular Biology. 20: 4879-87. PMID 10848613 DOI: 10.1128/Mcb.20.13.4879-4887.2000 |
0.356 |
|
| 2000 |
Trask TM, Trask BC, Ritty TM, Abrams WR, Rosenbloom J, Mecham RP. Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly. The Journal of Biological Chemistry. 275: 24400-6. PMID 10825173 DOI: 10.1074/Jbc.M003665200 |
0.768 |
|
| 2000 |
Trask BC, Trask TM, Broekelmann T, Mecham RP. The microfibrillar proteins MAGP-1 and fibrillin-1 form a ternary complex with the chondroitin sulfate proteoglycan decorin. Molecular Biology of the Cell. 11: 1499-507. PMID 10793130 DOI: 10.1091/Mbc.11.5.1499 |
0.777 |
|
| 1999 |
Davis EC, Blattel SA, Mecham RP. Remodeling of elastic fiber components in scleroderma skin. Connective Tissue Research. 40: 113-21. PMID 10761636 DOI: 10.3109/03008209909029107 |
0.343 |
|
| 1999 |
Robb BW, Wachi H, Schaub T, Mecham RP, Davis EC. Characterization of an in vitro model of elastic fiber assembly. Molecular Biology of the Cell. 10: 3595-605. PMID 10564258 DOI: 10.1091/Mbc.10.11.3595 |
0.398 |
|
| 1999 |
Zhang M, Pierce RA, Wachi H, Mecham RP, Parks WC. An open reading frame element mediates posttranscriptional regulation of tropoelastin and responsiveness to transforming growth factor β1 Molecular and Cellular Biology. 19: 7314-7326. PMID 10523620 DOI: 10.1128/Mcb.19.11.7314 |
0.323 |
|
| 1999 |
Trask TM, Ritty TM, Broekelmann T, Tisdale C, Mecham RP. N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly. The Biochemical Journal. 340: 693-701. PMID 10359653 DOI: 10.1042/Bj3400693 |
0.761 |
|
| 1999 |
Ritty TM, Broekelmann T, Tisdalet C, Milewicz DM, Mecham RP. Processing of the fibrillin-1 carboxyl-terminal domain Journal of Biological Chemistry. 274: 8933-8940. PMID 10085138 DOI: 10.1074/Jbc.274.13.8933 |
0.347 |
|
| 1999 |
Park PW, Broekelmann TJ, Mecham BR, Mecham RP. Characterization of the elastin binding domain in the cell-surface 25- kDa elastin-binding protein of Staphylococcus aureus (EbpS) Journal of Biological Chemistry. 274: 2845-2850. PMID 9915819 DOI: 10.1074/Jbc.274.5.2845 |
0.364 |
|
| 1998 |
Li DY, Faury G, Taylor DG, Davis EC, Boyle WA, Mecham RP, Stenzel P, Boak B, Keating MT. Novel arterial pathology in mice and humans hemizygous for elastin. The Journal of Clinical Investigation. 102: 1783-7. PMID 9819363 DOI: 10.1172/Jci4487 |
0.339 |
|
| 1998 |
Davis EC, Mecham RP. Intracellular trafficking of tropoelastin. Matrix Biology : Journal of the International Society For Matrix Biology. 17: 245-54. PMID 9749941 DOI: 10.1016/S0945-053X(98)90078-6 |
0.326 |
|
| 1998 |
Hausladen JM, Davis EC, Pierce RA, Mecham RP. Formation of the pulmonary vasculature: elastic fiber proteins as markers of cellular differentiation and vascular development. Chest. 114: 6S. PMID 9676600 DOI: 10.1378/Chest.114.1_Supplement.6S |
0.348 |
|
| 1998 |
Li DY, Brooke B, Davis EC, Mecham RP, Sorensen LK, Boak BB, Eichwald E, Keating MT. Elastin is an essential determinant of arterial morphogenesis. Nature. 393: 276-80. PMID 9607766 DOI: 10.1038/30522 |
0.321 |
|
| 1998 |
Faury G, Gamier S, Weiss AS, Wallach J, Fülöp T, Jacob MP, Mecham RP, Robert L, Verdetti J. Action of tropoelastin and synthetic elastin sequences on vascular tone and on free Ca2+ level in human vascular endothelial cells Circulation Research. 82: 328-336. PMID 9486661 DOI: 10.1161/01.Res.82.3.328 |
0.336 |
|
| 1998 |
Davis EC, Broekelmann TJ, Ozawa Y, Mecham RP. Identification of tropoelastin as a ligand for the 65-kD FK506-binding protein, FKBP65, in the secretory pathway. The Journal of Cell Biology. 140: 295-303. PMID 9442105 DOI: 10.1083/Jcb.140.2.295 |
0.344 |
|
| 1997 |
Fang J, Li X, Smiley E, Francke U, Mecham RP, Bonadio J. Mouse latent TGF-beta binding protein-2: molecular cloning and developmental expression. Biochimica Et Biophysica Acta. 1354: 219-30. PMID 9427531 DOI: 10.1016/S0167-4781(97)00104-8 |
0.345 |
|
| 1997 |
Mecham RP, Broekelmann TJ, Fliszar CJ, Shapiro SD, Welgus HG, Senior RM. Elastin degradation by matrix metalloproteinases: Cleavage site specificity and mechanisms of elastolysis Journal of Biological Chemistry. 272: 18071-18076. PMID 9218437 DOI: 10.1074/Jbc.272.29.18071 |
0.31 |
|
| 1997 |
Stenmark KR, Mecham RP. Cellular and molecular mechanisms of pulmonary vascular remodeling Annual Review of Physiology. 59: 89-144. PMID 9074758 DOI: 10.1146/Annurev.Physiol.59.1.89 |
0.317 |
|
| 1996 |
Tanaka Y, Bernstein ML, Mecham RP, Patterson GA, Cooper JD, Botney MD. Site-specific responses to monocrotaline-induced vascular injury: evidence for two distinct mechanisms of remodeling. American Journal of Respiratory Cell and Molecular Biology. 15: 390-7. PMID 8810644 DOI: 10.1165/Ajrcmb.15.3.8810644 |
0.325 |
|
| 1996 |
Brown-Augsburger P, Broekelmann T, Rosenbloom J, Mecham RP. Functional domains on elastin and microfibril-associated glycoprotein involved in elastic fibre assembly Biochemical Journal. 318: 149-155. PMID 8761465 DOI: 10.1042/Bj3180149 |
0.365 |
|
| 1996 |
Bashir MM, Han MD, Abrams WR, Tucker T, Ma RI, Gibson M, Ritty T, Mecham R, Rosenbloom J. Analysis of the human gene encoding latent transforming growth factor-β-binding protein-2 International Journal of Biochemistry and Cell Biology. 28: 531-542. PMID 8697098 DOI: 10.1016/1357-2725(95)00167-0 |
0.319 |
|
| 1996 |
Park PW, Rosenbloom J, Abrams WR, Mecham RP. Molecular cloning and expression of the gene for elastin-binding protein (ebpS) in Staphylococcus aureus Journal of Biological Chemistry. 271: 15803-15809. PMID 8663124 DOI: 10.1074/Jbc.271.26.15803 |
0.4 |
|
| 1996 |
Davis EC, Mecham RP. Selective degradation of accumulated secretory proteins in the endoplasmic reticulum. A possible clearance pathway for abnormal tropoelastin Journal of Biological Chemistry. 271: 3787-3794. PMID 8631995 DOI: 10.1074/Jbc.271.7.3787 |
0.328 |
|
| 1996 |
Park PW, Biedermann K, Mecham L, Bissett DL, Mecham RP. Lysozyme binds to elastin and protects elastin from elastase-mediated degradation Journal of Investigative Dermatology. 106: 1075-1080. PMID 8618042 DOI: 10.1111/1523-1747.Ep12339292 |
0.379 |
|
| 1996 |
Sakamoto H, Broekelmann T, Cheresh DA, Ramirez F, Rosenbloom J, Mecham RP. Cell-type specific recognition of RGD- and non-RGD-containing cell binding domains in fibrillin-1 Journal of Biological Chemistry. 271: 4916-4922. PMID 8617764 DOI: 10.1074/Jbc.271.9.4916 |
0.411 |
|
| 1995 |
Rosenbloom J, Koo H, Howard PS, Mecham R, Macarak EJ. Elastic fibers and their role in bladder extracellular matrix Advances in Experimental Medicine and Biology. 385: 161-172. PMID 8571827 DOI: 10.1007/978-1-4899-1585-6_19 |
0.364 |
|
| 1995 |
Shapiro SD, Fliszar CJ, Broekelmann TJ, Mecham RP, Senior RM, Welgus HG. Activation of the 92-kDa gelatinase by stromelysin and 4- aminophenylmercuric acetate. Differential processing and stabilization of the carboxyl-terminal domain by tissue inhibitor of metalloproteinases (TIMP) Journal of Biological Chemistry. 270: 6351-6356. PMID 7890773 DOI: 10.1074/Jbc.270.11.6351 |
0.338 |
|
| 1995 |
Park PW, Senior RM, Griffin GL, Broekelmann TJ, Susan Mudd M, Mecham RP. Binding and degradation of elastin by the staphylolytic enzyme lysostaphin International Journal of Biochemistry and Cell Biology. 27: 139-146. PMID 7767782 DOI: 10.1016/1357-2725(94)00086-Q |
0.334 |
|
| 1995 |
Gray AJ, Bishop JE, Reeves JT, Mecham RP, Laurent GJ. Partially degraded fibrin(ogen) stimulates fibroblast proliferation in vitro. American Journal of Respiratory Cell and Molecular Biology. 12: 684-90. PMID 7766431 DOI: 10.1165/Ajrcmb.12.6.7766431 |
0.352 |
|
| 1995 |
Yin W, Smiley E, Germiller J, Mecham RP, Florer JB, Wenstrup RJ, Bonadio J. Isolation of a novel latent transforming growth factor-β binding protein gene (LTBP-3) Journal of Biological Chemistry. 270: 10147-10160. PMID 7730318 DOI: 10.1074/Jbc.270.17.10147 |
0.313 |
|
| 1995 |
Brown-Augsburger P, Tisdale C, Broekelmann T, Sloan C, Mecham RP. Identification of an elastin cross-linking domain that joins three peptide chains. Possible role in nucleated assembly Journal of Biological Chemistry. 270: 17778-17783. PMID 7629078 DOI: 10.1074/Jbc.270.30.17778 |
0.344 |
|
| 1995 |
Thompson RW, Holmes DR, Mertens RA, Liao S, Botney MD, Mecham RP, Welgus HG, Parks WC. Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms: An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages Journal of Clinical Investigation. 96: 318-326. PMID 7615801 DOI: 10.1172/Jci118037 |
0.308 |
|
| 1995 |
Mariencheck MC, Davis EC, Zhang H, Ramirez F, Rosenbloom J, Gibson MA, Parks WC, Mecham RP. Fibrillin-1 and fibrillin-2 show temporal and tissue-specific regulation of expression in developing elastic tissues Connective Tissue Research. 31: 87-97. DOI: 10.3109/03008209509028396 |
0.319 |
|
| 1994 |
Bashir MM, Abrams WR, Rosenbloom J, Kucich U, Bacarra M, Han MD, Brown-Augsberger P, Mecham R. Microfibril-associated glycoprotein: Characterization of the bovine gene and of the recombinantly expressed protein Biochemistry. 33: 593-600. PMID 8286390 DOI: 10.1021/Bi00168A026 |
0.375 |
|
| 1994 |
Lee KA, Pierce RA, Davis EC, Mecham RP, Parks WC. Conversion to an elastogenic phenotype by fetal hyaline chondrocytes is accompanied by altered expression of elastin-related macromolecules Developmental Biology. 163: 241-252. PMID 8174780 DOI: 10.1006/Dbio.1994.1140 |
0.357 |
|
| 1994 |
Stenmark KR, Durmowicz AG, Roby JD, Mecham RP, Parks WC. Persistence of the fetal pattern of tropoelastin gene expression in severe neonatal bovine pulmonary hypertension. The Journal of Clinical Investigation. 93: 1234-42. PMID 8132763 DOI: 10.1172/Jci117077 |
0.301 |
|
| 1994 |
Zhang H, Apfelroth SD, Hu W, Davis EC, Sanguineti C, Bonadio J, Mecham RP, Ramirez F. Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices Journal of Cell Biology. 124: 855-863. PMID 8120105 DOI: 10.1083/Jcb.124.5.855 |
0.328 |
|
| 1994 |
Lee KA, Pierce RA, Mecham RP, Parks WC. Increased mesenchymal cell density accompanies induction of tropoelastin expression in developing elastic tissue Developmental Dynamics. 200: 53-67. PMID 8081014 DOI: 10.1002/Aja.1002000106 |
0.315 |
|
| 1994 |
Brown-Augsburger P, Broekelmann T, Mecham L, Mercer R, Gibson MA, Cleary EG, Abrams WR, Rosenbloom J, Mecham RP. Microfibril-associated glycoprotein binds to the carboxyl-terminal domain of tropoelastin and is a substrate for transglutaminase Journal of Biological Chemistry. 269: 28443-28449. PMID 7961786 |
0.327 |
|
| 1993 |
Liptay MJ, Parks WC, Mecham RP, Roby J, Kaiser LR, Cooper JD, Botney MD. Neointimal macrophages colocalize with extracellular matrix gene expression in human atherosclerotic pulmonary arteries Journal of Clinical Investigation. 91: 588-594. PMID 8432864 DOI: 10.1172/Jci116238 |
0.327 |
|
| 1993 |
Rosenbloom J, Abrams WR, Mecham R. Extracellular matrix 4: The elastic fiber The Faseb Journal. 7: 1208-1218. DOI: 10.1096/Fasebj.7.13.8405806 |
0.364 |
|
| 1992 |
Brown PL, Mecham L, Tisdale C, Mecham RP. The cysteine residues in the carboxy terminal domain of tropoelastin form an intrachain disulfide bond that stabilizes a loop structure and positively charged pocket Biochemical and Biophysical Research Communications. 186: 549-555. PMID 1632791 DOI: 10.1016/S0006-291X(05)80843-5 |
0.327 |
|
| 1992 |
Botney MD, Parks WC, Crouch EC, Stenmark K, Mecham RP. Transforming growth factor-β1 is decreased in remodeling hypertensive bovine pulmonary arteries Journal of Clinical Investigation. 89: 1629-1635. PMID 1569202 DOI: 10.1172/Jci115759 |
0.305 |
|
| 1992 |
Hall R, Hunt PD, Carrington M, Simmons D, Williamson S, Mecham RP, Tait A. Mimicry of elastin repetitive motifs by Theileria annulata sporozoite surface antigen Molecular and Biochemical Parasitology. 53: 105-112. PMID 1501630 DOI: 10.1016/0166-6851(92)90012-9 |
0.316 |
|
| 1992 |
Sudbeck BD, Jeffrey JJ, Welgus HG, Mecham RP, McCourt D, Parks WC. Purification and characterization of bovine interstitial collagenase and tissue inhibitor of metalloproteinases Archives of Biochemistry and Biophysics. 293: 370-376. PMID 1311165 DOI: 10.1016/0003-9861(92)90408-O |
0.336 |
|
| 1991 |
Grosso LE, Parks WC, Wu L, Mecham RP. Fibroblast adhesion to recombinant tropoelastin expressed as a Protein A-fusion protein Biochemical Journal. 273: 517-522. PMID 1996952 DOI: 10.1042/Bj2730517 |
0.362 |
|
| 1991 |
Mecham RP. Introduction: catalyzing matrix stability American Journal of Respiratory Cell and Molecular Biology. 5: 205. PMID 1910805 DOI: 10.1165/Ajrcmb/5.3.205 |
0.383 |
|
| 1991 |
Grosso LE, Park PW, Mecham RP. Characterization of a putative clone for the 67-kilodalton elastin/laminin receptor suggests that it encodes a cytoplasmic protein rather than a cell surface receptor. Biochemistry. 30: 3346-50. PMID 1849001 DOI: 10.1021/Bi00227A026 |
0.341 |
|
| 1991 |
Durmowicz AG, Badesch DB, Parks WC, Mecham RP, Stenmark KR. Hypoxia-induced inhibition of tropoelastin synthesis by neonatal calf pulmonary artery smooth muscle cells. American Journal of Respiratory Cell and Molecular Biology. 5: 464-9. PMID 1718337 DOI: 10.1165/Ajrcmb/5.5.464 |
0.336 |
|
| 1991 |
Hinek A, Mecham RP, Keeley F, Rabinovitch M. Impaired elastin fiber assembly related to reduced 67-kD elastin-binding protein in fetal lamb ductus arteriosus and in cultured aortic smooth muscle cells treated with chondroitin sulfate Journal of Clinical Investigation. 88: 2083-2094. PMID 1661296 DOI: 10.1172/Jci115538 |
0.362 |
|
| 1991 |
Mecham RP. Receptors for laminin on mammalian cells Faseb Journal. 5: 2538-2546. PMID 1651264 DOI: 10.1096/Fasebj.5.11.1651264 |
0.361 |
|
| 1990 |
Mecham RP, Heuser J. Three-dimensional organization of extracellular matrix in elastic cartilage as viewed by quick freeze, deep etch electron microscopy Connective Tissue Research. 24: 83-93. PMID 2354636 DOI: 10.3109/03008209009152425 |
0.368 |
|
| 1990 |
Indik Z, Abrams WR, Kucich U, Gibson CW, Mecham RP, Rosenbloom J. Production of recombinant human tropoelastin: Characterization and demonstration of immunologic and chemotactic activity Archives of Biochemistry and Biophysics. 280: 80-86. PMID 2191629 DOI: 10.1016/0003-9861(90)90521-Y |
0.348 |
|
| 1989 |
Chow M, Boyd CD, Iruela-Arispe ML, Wrenn DS, Mecham R, Helene Sage E. Characterization of elastin protein and mRNA from salmonid fish (Oncorhynchus kisutch) Comparative Biochemistry and Physiology -- Part B: Biochemistry And. 93: 835-845. PMID 2805642 DOI: 10.1016/0305-0491(89)90055-2 |
0.302 |
|
| 1989 |
Noguchi A, Reddy R, Kursar JD, Parks WC, Mecham RP. Smooth muscle isoactin and elastin in fetal bovine lung Experimental Lung Research. 15: 537-552. PMID 2767003 DOI: 10.3109/01902148909069617 |
0.323 |
|
| 1989 |
Senior RM, Hinek A, Griffin GL, Pipoly DJ, Crouch EC, Mecham RP. Neutrophils show chemotaxis to type IV collagen and its 7S domain and contain a 67 kD type IV collagen binding protein with lectin properties American Journal of Respiratory Cell and Molecular Biology. 1: 479-487. PMID 2561590 DOI: 10.1165/Ajrcmb/1.6.479 |
0.366 |
|
| 1989 |
Mecham RP, Hinek A, Entwistle R, Wrenn DS, Griffin GL, Senior RM. Elastin binds to a multifunctional 67-kilodalton peripheral membrane protein. Biochemistry. 28: 3716-22. PMID 2546580 DOI: 10.1021/Bi00435A014 |
0.353 |
|
| 1989 |
Crouch EC, Parks WC, Rosenbaum JL, Chang D, Whitehouse L, Wu LJ, Stenmark KR, Orton EC, Mecham RP. Regulation of collagen production by medial smooth muscle cells in hypoxic pulmonary hypertension. The American Review of Respiratory Disease. 140: 1045-51. PMID 2478055 DOI: 10.1164/Ajrccm/140.4.1045 |
0.345 |
|
| 1988 |
Parks WC, Whitehouse LA, Wu LC, Mecham RP. Terminal differentiation of nuchal ligament fibroblasts: Characterization of synthetic properties and responsiveness to external stimuli Developmental Biology. 129: 555-564. PMID 3417052 DOI: 10.1016/0012-1606(88)90400-9 |
0.3 |
|
| 1988 |
Grosso LE, Mecham RP. In vitro processing of tropoelastin: Investigation of a possible transport function associated with the carboxy-terminal domain Biochemical and Biophysical Research Communications. 153: 545-551. PMID 3382387 DOI: 10.1016/S0006-291X(88)81129-X |
0.328 |
|
| 1988 |
Stenmark KR, Orton EC, Reeves JT, Voelkel NF, Crouch EC, Parks WC, Mecham RP. Vascular remodeling in neonatal pulmonary hypertension: Role of the smooth muscle cell Chest. 93: 127S-133S. PMID 3342691 DOI: 10.1378/Chest.93.3_Supplement.127S |
0.349 |
|
| 1988 |
Mecham RP, Hinek A, Cleary EG, Kucich U, Lee SJ, Rosenbloom J. Development of immunoreagents to ciliary zonules that react with protein components of elastic fiber microfibrils and with elastin-producing cells Biochemical and Biophysical Research Communications. 151: 822-826. PMID 3279956 DOI: 10.1016/S0006-291X(88)80355-3 |
0.343 |
|
| 1988 |
Hinek A, Wrenn DS, Mecham RP, Barondes SH. The elastin receptor: a galactoside-binding protein. Science (New York, N.Y.). 239: 1539-41. PMID 2832941 DOI: 10.1126/Science.2832941 |
0.354 |
|
| 1987 |
Mecham RP. [12] Modulation of elastin synthesis: In vitro models Methods in Enzymology. 144: 232-246. PMID 3626873 DOI: 10.1016/0076-6879(87)44181-5 |
0.314 |
|
| 1987 |
Mecham RP, Whitehouse LA, Wrenn DS, Parks WC, Griffin GL, Senior RM, Crouch EC, Stenmark KR, Voelkel NF. Smooth muscle-mediated connective tissue remodeling in pulmonary hypertension Science. 237: 423-426. PMID 3603030 DOI: 10.1126/Science.3603030 |
0.326 |
|
| 1987 |
Sage H, Mecham R. Extracellular matrix-induced synthesis of a low molecular weight collagen by fetal calf ligament fibroblasts. Connective Tissue Research. 16: 41-56. PMID 2952447 DOI: 10.3109/03008208709001993 |
0.326 |
|
| 1987 |
Cox DL, Mecham RP, Koob TJ. Site-specific variation in amino acid composition of skate egg capsule (Raja erinacea Mitchell, 1825) Journal of Experimental Marine Biology and Ecology. 107: 71-74. DOI: 10.1016/0022-0981(87)90124-9 |
0.327 |
|
| 1986 |
Wrenn DS, Griffin GL, Senior RM, Mecham RP. Characterization of biologically active domains on elastin: Identification of a monoclonal antibody to a cell recognition site Biochemistry. 25: 5172-5176. PMID 2429696 DOI: 10.1021/Bi00366A028 |
0.306 |
|
| 1984 |
Mecham RP, Griffin GL, Madaras JG, Senior RM. Appearance of chemotactic responsiveness to elastin peptides by developing fetal bovine ligament fibroblasts parallels the onset of elastin production Journal of Cell Biology. 98: 1813-1816. PMID 6725401 DOI: 10.1083/Jcb.98.5.1813 |
0.329 |
|
| 1984 |
Mecham RP, Madaras JG, Senior RM. Extracellular matrix-specific induction of elastogenic differentiation and maintenance of phenotypic stability in bovine ligament fibroblasts Journal of Cell Biology. 98: 1804-1812. PMID 6725400 DOI: 10.1083/Jcb.98.5.1804 |
0.351 |
|
| 1983 |
Mecham RP, Madaras J, McDonald JA, Ryan U. Elastin production by cultured calf pulmonary artery endothelial cells Journal of Cellular Physiology. 116: 282-288. PMID 6350324 DOI: 10.1002/Jcp.1041160304 |
0.342 |
|
| 1983 |
Sage H, Mecham R, Johnson C, Bornstein P. Fetal calf ligament fibroblasts in culture secrete a low molecular weight collagen with a unique resistance to proteolytic degradation. The Journal of Cell Biology. 97: 1933-8. PMID 6315746 DOI: 10.1083/Jcb.97.6.1933 |
0.329 |
|
| 1982 |
Senior RM, Griffin GL, Mecham RP. Chemotactic responses of fibroblasts to tropoelastin and elastin-derived peptides Journal of Clinical Investigation. 70: 614-618. PMID 7107897 DOI: 10.1172/Jci110654 |
0.332 |
|
| 1982 |
Cox DL, Mecham RP, Sexton OJ. Lysine derived cross-links are present in a non-elastin, proline-rich protein fraction of Iguana iguana eggshell Comparative Biochemistry and Physiology -- Part B: Biochemistry And. 72: 619-623. PMID 6181935 DOI: 10.1016/0305-0491(82)90515-6 |
0.311 |
|
| 1982 |
Mecham RP, Lange G. Antigenicity of elastin: Characterization of major antigenic determinants on purified insoluble elastin Biochemistry. 21: 669-673. PMID 6176263 DOI: 10.1021/Bi00533A013 |
0.302 |
|
| 1981 |
Mecham RP. Effects of extracellular matrix upon elastogenesis Connective Tissue Research. 8: 241-244. PMID 6455252 DOI: 10.3109/03008208109152382 |
0.316 |
|
| 1981 |
Mecham RP, Lange G, Madaras J, Starcher B. Elastin synthesis by ligamentum nuchae fibroblasts: Effects of culture conditions and extracellular matrix on elastin production Journal of Cell Biology. 90: 332-338. PMID 6169729 DOI: 10.1083/Jcb.90.2.332 |
0.341 |
|
| 1981 |
Starcher BC, Mecham RP. Desmosine radioimmunoassay as a means of studying elastogenesis in cell culture Connective Tissue Research. 8: 255-258. PMID 6114811 DOI: 10.3109/03008208109152385 |
0.333 |
|
| 1979 |
Mecham RP, Foster JA. Characterization of insoluble elastin from copper-deficient pigs. Its usefulness in elastin sequence studies. Biochimica Et Biophysica Acta. 577: 147-58. PMID 427211 DOI: 10.1016/0005-2795(79)90017-5 |
0.314 |
|
| 1979 |
Quintarelli G, Starcher BC, Vocaturo A, Gianfilippo FD, Gotte L, Mecham RP. Fibrogenesis and biosynthesis of elastin in cartilage Connective Tissue Research. 7: 1-19. PMID 158482 DOI: 10.3109/03008207909152348 |
0.355 |
|
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