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Paul Greengard, Ph.D. - Publications

Affiliations: 
Yale University School of Medicine, New Haven, CT 
 1957-1967 Geigy Research Labratories 
 1969-1983 Yale University, New Haven, CT 
 1983- Molecular and Cellular Neuroscience Rockefeller University, New York, NY, United States 
Area:
neurological and psychiatric disorders, neuro- and psychoactive drugs
Website:
http://www.nobelprize.org/nobel_prizes/medicine/laureates/2000/greengard-bio.html
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Year Citation  Score
2023 Montalban E, Giralt A, Taing L, Nakamura Y, Pelosi A, Brown M, de Pins B, Valjent E, Martin M, Nairn AC, Greengard P, Flajolet M, Hervé D, Gambardella N, Roussarie JP, et al. Operant training for highly palatable food alters translating mRNA in nucleus accumbens D2 neurons and reveals a modulatory role of Neurochondrin. Biological Psychiatry. PMID 37579933 DOI: 10.1016/j.biopsych.2023.08.006  0.582
2023 Montalban E, Giralt A, Taing L, Nakamura Y, Pelosi A, Brown M, de Pins B, Valjent E, Martin M, Nairn AC, Greengard P, Flajolet M, Herv D, Gambardella N, Roussarie JP, et al. Operant training for highly palatable food alters translating mRNA in nucleus accumbens D2 neurons and reveals a modulatory role of . Biorxiv : the Preprint Server For Biology. PMID 36945487 DOI: 10.1101/2023.03.07.531496  0.584
2022 Marion-Poll L, Roussarie JP, Taing L, Dard-Dascot C, Servant N, Jaszczyszyn Y, Jordi E, Mulugeta E, Hervé D, Bourc'his D, Greengard P, Thermes C, Girault JA. DNA methylation and hydroxymethylation characterize the identity of D1 and D2 striatal projection neurons. Communications Biology. 5: 1321. PMID 36456703 DOI: 10.1038/s42003-022-04269-w  0.455
2022 Jin C, Wang J, Wang Y, Jia B, Guo X, Yang G, Xu P, Greengard P, Zhou R, Shi Y. Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation. Proceedings of the National Academy of Sciences of the United States of America. 119: e2122292119. PMID 35298330 DOI: 10.1073/pnas.2122292119  0.304
2022 Montalban E, Giralt A, Taing L, Schut EHS, Supiot LF, Castell L, Nakamura Y, de Pins B, Pelosi A, Goutebroze L, Tuduri P, Wang W, Neiburga KD, Vestito L, Castel J, ... ... Greengard P, et al. Translational profiling of mouse dopaminoceptive neurons reveals region-specific gene expression, exon usage, and striatal prostaglandin E2 modulatory effects. Molecular Psychiatry. PMID 35177825 DOI: 10.1038/s41380-022-01439-4  0.635
2021 Seo JS, Mantas I, Svenningsson P, Greengard P. Ependymal cells-CSF flow regulates stress-induced depression. Molecular Psychiatry. PMID 34234280 DOI: 10.1038/s41380-021-01202-1  0.401
2021 Xu P, Chang JC, Zhou X, Wang W, Bamkole M, Wong E, Bettayeb K, Jiang LL, Huang T, Luo W, Xu H, Nairn AC, Flajolet M, Ip NY, Li YM, ... Greengard P, et al. GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. The Journal of Experimental Medicine. 218. PMID 34156424 DOI: 10.1084/jem.20202446  0.792
2021 Umschweif G, Medrihan L, Guillén-Samander A, Wang W, Sagi Y, Greengard P. Identification of Neurensin-2 as a novel modulator of emotional behavior. Molecular Psychiatry. PMID 33742167 DOI: 10.1038/s41380-021-01058-5  0.806
2021 Umschweif G, Medrihan L, McCabe KA, Sagi Y, Greengard P. Activation of the p11/SMARCA3/Neurensin-2 pathway in parvalbumin interneurons mediates the response to chronic antidepressants. Molecular Psychiatry. PMID 33723417 DOI: 10.1038/s41380-021-01059-4  0.801
2021 Ledo JH, Zhang R, Mesin L, Mourão-Sá D, Azevedo EP, Silva HM, Troyanskaya OG, Bustos V, Greengard P. Correction: Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development. Plos One. 16: e0247680. PMID 33606833 DOI: 10.1371/journal.pone.0247680  0.773
2021 Karayol R, Medrihan L, Warner-Schmidt JL, Fait BW, Rao MN, Holzner EB, Greengard P, Heintz N, Schmidt EF. Serotonin receptor 4 in the hippocampus modulates mood and anxiety. Molecular Psychiatry. PMID 33441982 DOI: 10.1038/s41380-020-00994-y  0.805
2020 Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, ... ... Greengard P, et al. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease. Nature. PMID 32879487 DOI: 10.1038/S41586-020-2681-2  0.308
2020 Ledo JH, Zhang R, Mesin L, Mourão-Sá D, Azevedo EP, Troyanskaya OG, Bustos V, Greengard P. Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development. Plos One. 15: e0237773. PMID 32822378 DOI: 10.1371/Journal.Pone.0237773  0.792
2020 Ledo JH, Liebmann T, Zhang R, Chang JC, Azevedo EP, Wong E, Silva HM, Troyanskaya OG, Bustos V, Greengard P. Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia. Molecular Psychiatry. PMID 32792660 DOI: 10.1038/S41380-020-0856-8  0.799
2020 Luo W, Ip FCF, Fu G, Cheung K, Tian Y, Hu Y, Sinha A, Cheng EYL, Wu X, Bustos V, Greengard P, Li YM, Sinha SC, Ip NY. A pentacyclic triterpene from targets γ-secretase. Acs Chemical Neuroscience. PMID 32786303 DOI: 10.1021/Acschemneuro.0C00389  0.716
2020 Roussarie JP, Yao V, Rodriguez-Rodriguez P, Oughtred R, Rust J, Plautz Z, Kasturia S, Albornoz C, Wang W, Schmidt EF, Dannenfelser R, Tadych A, Brichta L, Barnea-Cramer A, Heintz N, ... ... Greengard P, et al. Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis. Neuron. PMID 32603655 DOI: 10.1016/J.Neuron.2020.06.010  0.373
2020 Chottekalapanda RU, Kalik S, Gresack J, Ayala A, Gao M, Wang W, Meller S, Aly A, Schaefer A, Greengard P. AP-1 controls the p11-dependent antidepressant response. Molecular Psychiatry. PMID 32439846 DOI: 10.1038/S41380-020-0767-8  0.394
2020 Medrihan L, Umschweif G, Sinha A, Reed S, Lee J, Gindinova K, Sinha SC, Greengard P, Sagi Y. Reduced Kv3.1 Activity in Dentate Gyrus Parvalbumin Cells Induces Vulnerability to Depression. Biological Psychiatry. PMID 32331822 DOI: 10.1016/J.Biopsych.2020.02.1179  0.791
2020 Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ. Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. Nature Neuroscience. PMID 31911656 DOI: 10.1038/S41593-019-0583-0  0.488
2019 Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ. Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. Nature Neuroscience. PMID 31844313 DOI: 10.1038/S41593-019-0556-3  0.497
2019 Pulina MV, Hopkins M, Haroutunian V, Greengard P, Bustos V. C99 selectively accumulates in vulnerable neurons in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31677937 DOI: 10.1016/J.Jalz.2019.09.002  0.701
2019 Seo JS, Wei J, Qin L, Kim Y, Yan Z, Greengard P. Correction: Cellular and molecular basis for stress-induced depression. Molecular Psychiatry. PMID 31641216 DOI: 10.1038/S41380-019-0544-8  0.6
2019 Riessland M, Kolisnyk B, Kim TW, Cheng J, Ni J, Pearson JA, Park EJ, Dam K, Acehan D, Ramos-Espiritu LS, Wang W, Zhang J, Shim JW, Ciceri G, Brichta L, ... ... Greengard P, et al. Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons. Cell Stem Cell. PMID 31543366 DOI: 10.1016/J.Stem.2019.08.013  0.807
2019 Wang ZJ, Zhong P, Ma K, Seo JS, Yang F, Hu Z, Zhang F, Lin L, Wang J, Liu T, Matas E, Greengard P, Yan Z. Correction: Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice. Molecular Psychiatry. PMID 31520066 DOI: 10.1038/s41380-019-0524-z  0.766
2019 Sargin D, Chottekalapanda RU, Perit KE, Yao V, Chu D, Sparks DW, Kalik S, Power SK, Troyanskaya OG, Schmidt EF, Greengard P, Lambe EK. Mapping the physiological and molecular markers of stress and SSRI antidepressant treatment in S100a10 corticostriatal neurons. Molecular Psychiatry. PMID 31431686 DOI: 10.1038/S41380-019-0473-6  0.656
2019 Jin J, Cheng J, Lee KW, Amreen B, McCabe K, Pitcher C, Liebmann T, Greengard P, Flajolet M. Cholinergic neurons of the medial septum are crucial for sensorimotor gating. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31028115 DOI: 10.1523/Jneurosci.0950-18.2019  0.804
2019 Azevedo EP, Pomeranz L, Cheng J, Schneeberger M, Vaughan R, Stern SA, Tan B, Doerig K, Greengard P, Friedman JM. A Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake. Neuron. PMID 30930044 DOI: 10.1016/J.Neuron.2019.03.011  0.711
2019 Wong E, Liao GP, Chang JC, Xu P, Li YM, Greengard P. GSAP modulates γ-secretase specificity by inducing conformational change in PS1. Proceedings of the National Academy of Sciences of the United States of America. PMID 30850537 DOI: 10.1073/pnas.1820160116  0.412
2019 Oh SJ, Cheng J, Jang JH, Arace J, Jeong M, Shin CH, Park J, Jin J, Greengard P, Oh YS. Hippocampal mossy cell involvement in behavioral and neurogenic responses to chronic antidepressant treatment. Molecular Psychiatry. PMID 30837688 DOI: 10.1016/J.Ibror.2019.07.725  0.797
2019 Sagi Y, Medrihan L, George K, Barney M, McCabe KA, Greengard P. Emergence of 5-HT5A signaling in parvalbumin neurons mediates delayed antidepressant action. Molecular Psychiatry. PMID 30804492 DOI: 10.1038/S41380-019-0379-3  0.819
2019 Jin J, Bhatti DL, Lee KW, Medrihan L, Cheng J, Wei J, Zhong P, Yan Z, Kooiker C, Song C, Ahn JH, Obermair GJ, Lee A, Gresack J, Greengard P, et al. Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior. Molecular Psychiatry. PMID 30760886 DOI: 10.1038/S41380-019-0371-Y  0.793
2019 Wang ZJ, Zhong P, Ma K, Seo JS, Yang F, Hu Z, Zhang F, Lin L, Wang J, Liu T, Matas E, Greengard P, Yan Z. Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice. Molecular Psychiatry. PMID 30659288 DOI: 10.1038/S41380-019-0351-2  0.783
2019 Cheng J, Umschweif G, Leung J, Sagi Y, Greengard P. HCN2 Channels in Cholinergic Interneurons of Nucleus Accumbens Shell Regulate Depressive Behaviors. Neuron. PMID 30638901 DOI: 10.1016/J.Neuron.2018.12.018  0.663
2018 Zhou M, Gresack J, Cheng J, Uryu K, Brichta L, Greengard P, Flajolet M. CK1δ over-expressing mice display ADHD-like behaviors, frontostriatal neuronal abnormalities and altered expressions of ADHD-candidate genes. Molecular Psychiatry. PMID 31363163 DOI: 10.1038/S41380-018-0233-Z  0.682
2018 Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Oh YS, Jang JH, Shin CH, Ohnishi YN, Hanada Y, Miyakawa T, Kim Y, Greengard P, Nishi A. Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine. Molecular Psychiatry. PMID 30531938 DOI: 10.1038/s41380-018-0316-x  0.673
2017 Riessland M, Kolisnyk B, Greengard P. Reactive Dopamine Leads to Triple Trouble in Nigral Neurons. Biochemistry. 56: 6409-6410. PMID 29188990 DOI: 10.1021/Acs.Biochem.7B01057  0.774
2017 Castello J, LeFrancois B, Flajolet M, Greengard P, Friedman E, Rebholz H. CK2 regulates 5-HT4 receptor signaling and modulates depressive-like behavior. Molecular Psychiatry. 23: 872-882. PMID 29158580 DOI: 10.1038/Mp.2017.240  0.301
2017 Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, ... ... Greengard P, et al. Building Bridges through Science. Neuron. 96: 730-735. PMID 29144972 DOI: 10.1016/J.Neuron.2017.09.028  0.574
2017 Nasca C, Bigio B, Zelli D, de Angelis P, Lau T, Okamoto M, Soya H, Ni J, Brichta L, Greengard P, Neve RL, Lee FS, McEwen BS. Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress. Neuron. 96: 402-413.e5. PMID 29024663 DOI: 10.1016/j.neuron.2017.09.020  0.49
2017 Pirhaji L, Milani P, Dalin S, Wassie BT, Dunn DE, Fenster RJ, Avila-Pacheco J, Greengard P, Clish CB, Heiman M, Lo DC, Fraenkel E. Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements. Nature Communications. 8: 623. PMID 28931805 DOI: 10.1038/S41467-017-00353-6  0.744
2017 Medrihan L, Sagi Y, Inde Z, Krupa O, Daniels C, Peyrache A, Greengard P. Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus. Neuron. PMID 28735749 DOI: 10.1016/J.Neuron.2017.06.044  0.805
2017 Musante V, Li L, Kanyo J, Lam TT, Colangelo CM, Cheng SK, Brody H, Greengard P, Le Novère N, Nairn AC. Reciprocal regulation of ARPP-16 by PKA and MAST-3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition. Elife. 6. PMID 28613156 DOI: 10.7554/Elife.24998  0.568
2017 Bustos V, Pulina MV, Kelahmetoglu Y, Sinha SC, Gorelick FS, Flajolet M, Greengard P. Bidirectional regulation of Aβ levels by Presenilin 1. Proceedings of the National Academy of Sciences of the United States of America. PMID 28533411 DOI: 10.1073/Pnas.1705235114  0.792
2017 Bustos V, Pulina MV, Bispo A, Lam A, Flajolet M, Gorelick FS, Greengard P. Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome-lysosome fusion. Proceedings of the National Academy of Sciences of the United States of America. PMID 28533369 DOI: 10.1073/Pnas.1705240114  0.739
2017 Seo JS, Zhong P, Liu A, Yan Z, Greengard P. Elevation of p11 in lateral habenula mediates depression-like behavior. Molecular Psychiatry. PMID 28507317 DOI: 10.1038/mp.2017.96  0.555
2017 Devor A, Andreassen OA, Wang Y, Mäki-Marttunen T, Smeland OB, Fan CC, Schork AJ, Holland D, Thompson WK, Witoelar A, Chen CH, Desikan RS, McEvoy LK, Djurovic S, Greengard P, et al. Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia. Molecular Psychiatry. PMID 28348379 DOI: 10.1038/Mp.2017.33  0.535
2017 Andrade EC, Musante V, Horiuchi A, Matsuzaki H, Brody AH, Wu T, Greengard P, Taylor JR, Nairn AC. ARPP-16 is a striatal-enriched inhibitor of protein phosphatase 2A regulated by microtubule-associated serine/threonine kinase 3 (Mast 3 kinase). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28167675 DOI: 10.1523/JNEUROSCI.4559-15.2017  0.828
2017 Green H, Zhang X, Tiklova K, Volakakis N, Brodin L, Berg L, Greengard P, Perlmann T, Svenningsson P. Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28137881 DOI: 10.1073/pnas.1621218114  0.468
2017 Netzer WJ, Bettayeb K, Sinha SC, Flajolet M, Greengard P, Bustos V. Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage. Proceedings of the National Academy of Sciences of the United States of America. PMID 28115709 DOI: 10.1073/Pnas.1620963114  0.719
2017 Ceglia I, Lee KW, Cahill ME, Graves SM, Dietz D, Surmeier DJ, Nestler EJ, Nairn AC, Greengard P, Kim Y. WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine. Proceedings of the National Academy of Sciences of the United States of America. PMID 28115704 DOI: 10.1073/Pnas.1621185114  0.772
2017 Musante V, Li L, Kanyo J, Lam TT, Colangelo CM, Cheng SK, Brody AH, Greengard P, Novère NL, Nairn AC. Author response: Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition Elife. DOI: 10.7554/Elife.24998.035  0.528
2017 Girault J-, Greengard P, Nairn AC. Regulation of Striatal Signaling by Protein Phosphatases Handbook of Behavioral Neuroscience. 24: 583-607. DOI: 10.1016/B978-0-12-802206-1.00029-5  0.554
2016 Estep CM, Galtieri DJ, Zampese E, Goldberg JA, Brichta L, Greengard P, Surmeier DJ. Transient Activation of GABAB Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons. Plos One. 11: e0169044. PMID 28036359 DOI: 10.1371/Journal.Pone.0169044  0.573
2016 Nishi A, Matamales M, Musante V, Valjent E, Kuroiwa M, Kitahara Y, Rebholz H, Greengard P, Girault JA, Nairn AC. Glutamate counteracts dopamine/PKA signaling via dephosphorylation of DARPP-32 Ser97 and alteration of its cytonuclear distribution. The Journal of Biological Chemistry. PMID 27998980 DOI: 10.1074/jbc.M116.752402  0.676
2016 Milosevic A, Liebmann T, Knudsen M, Schintu N, Svenningsson P, Greengard P. Cell- and region-specific expression of depression-related protein p11 (S100a10) in the brain. The Journal of Comparative Neurology. PMID 27616678 DOI: 10.1002/cne.24113  0.51
2016 Seo JS, Wei J, Qin L, Kim Y, Yan Z, Greengard P. Cellular and molecular basis for stress-induced depression. Molecular Psychiatry. PMID 27457815 DOI: 10.1038/mp.2016.118  0.795
2016 Shen W, Plotkin JL, Francardo V, Ko WK, Xie Z, Li Q, Fieblinger T, Wess J, Neubig RR, Lindsley CW, Conn PJ, Greengard P, Bezard E, Cenci MA, Surmeier DJ. M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia. Neuron. 90: 1139. PMID 27253449 DOI: 10.1016/J.Neuron.2016.05.017  0.511
2016 Li Z, Kelly L, Heiman M, Greengard P, Friedman JM. Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake. Cell Metabolism. 23: 945. PMID 27166950 DOI: 10.1016/j.cmet.2016.04.014  0.334
2016 Bettayeb K, Hooli BV, Parrado AR, Randolph L, Varotsis D, Aryal S, Gresack J, Tanzi RE, Greengard P, Flajolet M. Relevance of the COPI complex for Alzheimer's disease progression in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114526 DOI: 10.1073/Pnas.1604176113  0.308
2016 Bettayeb K, Chang JC, Luo W, Aryal S, Varotsis D, Randolph L, Netzer WJ, Greengard P, Flajolet M. δ-COP modulates Aβ peptide formation via retrograde trafficking of APP. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114525 DOI: 10.1073/Pnas.1604156113  0.32
2016 Marongiu R, Arango-Lievano M, Francardo V, Morgenstern P, Zhang X, Cenci MA, Svenningsson P, Greengard P, Kaplitt MG. Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 26787858 DOI: 10.1073/Pnas.1524387113  0.791
2016 Schintu N, Zhang X, Alvarsson A, Marongiu R, Kaplitt MG, Greengard P, Svenningsson P. p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism. Proceedings of the National Academy of Sciences of the United States of America. PMID 26787846 DOI: 10.1073/Pnas.1524303113  0.798
2016 Virk MS, Sagi Y, Medrihan L, Leung J, Kaplitt MG, Greengard P. Opposing roles for serotonin in cholinergic neurons of the ventral and dorsal striatum. Proceedings of the National Academy of Sciences of the United States of America. PMID 26733685 DOI: 10.1073/Pnas.1524183113  0.797
2016 Green H, Brodin L, Greengard P, Berg L, Svenningsson P. Abstract # 1792 Peripheral inflammatory mediators and p11 levels in peripheral blood mononuclear cells from patients with Parkinson’s disease Brain, Behavior, and Immunity. 57: e24-e25. DOI: 10.1016/j.bbi.2016.07.083  0.438
2015 Li Z, Kelly L, Heiman M, Greengard P, Friedman JM. Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake. Cell Metabolism. 22: 1059-67. PMID 26655697 DOI: 10.1016/J.Cmet.2015.10.012  0.512
2015 Engmann O, Giralt A, Gervasi N, Marion-Poll L, Gasmi L, Filhol O, Picciotto MR, Gilligan D, Greengard P, Nairn AC, Hervé D, Girault JA. DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons. Nature Communications. 6: 10099. PMID 26639316 DOI: 10.1038/ncomms10099  0.829
2015 Shen W, Plotkin JL, Francardo V, Ko WK, Xie Z, Li Q, Fieblinger T, Wess J, Neubig RR, Lindsley CW, Conn PJ, Greengard P, Bezard E, Cenci MA, Surmeier DJ. M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia. Neuron. 88: 762-773. PMID 26590347 DOI: 10.1016/J.Neuron.2015.10.039  0.568
2015 Lee KW, Westin L, Kim J, Chang JC, Oh YS, Amreen B, Gresack J, Flajolet M, Kim D, Aperia A, Kim Y, Greengard P. Alteration by p11 of mGluR5 localization regulates depression-like behaviors. Molecular Psychiatry. PMID 26370144 DOI: 10.1038/Mp.2015.132  0.699
2015 Ceglia I, Reitz C, Gresack J, Ahn JH, Bustos V, Bleck M, Zhang X, Martin G, Simon SM, Nairn AC, Greengard P, Kim Y. APP intracellular domain-WAVE1 pathway reduces amyloid-β production. Nature Medicine. PMID 26280122 DOI: 10.1038/Nm.3924  0.747
2015 Brichta L, Shin W, Jackson-Lewis V, Blesa J, Yap EL, Walker Z, Zhang J, Roussarie JP, Alvarez MJ, Califano A, Przedborski S, Greengard P. Identification of neurodegenerative factors using translatome-regulatory network analysis. Nature Neuroscience. PMID 26214373 DOI: 10.1038/Nn.4070  0.599
2015 Wang H, Warner-Schmidt J, Varela S, Enikolopov G, Greengard P, Flajolet M. Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice. Proceedings of the National Academy of Sciences of the United States of America. 112: 9745-50. PMID 26195764 DOI: 10.1073/Pnas.1510291112  0.72
2015 Plattner F, Hayashi K, Hernández A, Benavides DR, Tassin TC, Tan C, Day J, Fina MW, Yuen EY, Yan Z, Goldberg MS, Nairn AC, Greengard P, Nestler EJ, Taussig R, et al. The role of ventral striatal cAMP signaling in stress-induced behaviors. Nature Neuroscience. 18: 1094-100. PMID 26192746 DOI: 10.1038/Nn.4066  0.82
2015 Lazenka MF, Tomarchio A, Lichtman AH, Greengard P, Flajolet M, Selley DE, Sim-Selley LJ. Role of dopamine type 1 receptors and DARPP-32 in Δ9-THC-mediated induction of ΔFosB in the mouse forebrain. The Journal of Pharmacology and Experimental Therapeutics. PMID 26099530 DOI: 10.1124/Jpet.115.224428  0.395
2015 Sagi Y, Heiman M, Peterson JD, Musatov S, Scarduzio M, Logan SM, Kaplitt MG, Surmeier DJ, Heintz N, Greengard P. Erratum: Nitric oxide regulates synaptic transmission between spiny projection neurons (Proc Natl Acad Sci USA (2014) 111 49 (17636-17641) DOI: 10.1073/pnas.1420162111) Proceedings of the National Academy of Sciences of the United States of America. 112. PMID 25787251 DOI: 10.1073/Pnas.1504794112  0.585
2015 Uematsu K, Heiman M, Zelenina M, Padovan J, Chait BT, Aperia A, Nishi A, Greengard P. Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function. Journal of Neurochemistry. 132: 677-86. PMID 25639954 DOI: 10.1111/Jnc.13038  0.415
2015 Wang H, Warner-Schmidt J, Varela S, Enikolopov G, Greengard P, Flajolet M. Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice Proceedings of the National Academy of Sciences of the United States of America. 112: 9745-9750. DOI: 10.1073/pnas.1510291112  0.666
2014 Brichta L, Greengard P. Molecular determinants of selective dopaminergic vulnerability in Parkinson's disease: an update. Frontiers in Neuroanatomy. 8: 152. PMID 25565977 DOI: 10.3389/fnana.2014.00152  0.329
2014 Sagi Y, Heiman M, Peterson JD, Musatov S, Scarduzio M, Logan SM, Kaplitt MG, Surmeier DJ, Heintz N, Greengard P. Nitric oxide regulates synaptic transmission between spiny projection neurons. Proceedings of the National Academy of Sciences of the United States of America. 111: 17636-41. PMID 25413364 DOI: 10.1073/Pnas.1420162111  0.69
2014 Fieblinger T, Graves SM, Sebel LE, Alcacer C, Plotkin JL, Gertler TS, Chan CS, Heiman M, Greengard P, Cenci MA, Surmeier DJ. Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia. Nature Communications. 5: 5316. PMID 25360704 DOI: 10.1038/Ncomms6316  0.532
2014 Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, ... Greengard P, et al. Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease. Plos Biology. 12: e1001923. PMID 25093460 DOI: 10.1371/Journal.Pbio.1001923  0.676
2014 Plotkin JL, Day M, Peterson JD, Xie Z, Kress GJ, Rafalovich I, Kondapalli J, Gertler TS, Flajolet M, Greengard P, Stavarache M, Kaplitt MG, Rosinski J, Chan CS, Surmeier DJ. Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease. Neuron. 83: 178-88. PMID 24991961 DOI: 10.1016/J.Neuron.2014.05.032  0.707
2014 Meyer DA, Torres-Altoro MI, Tan Z, Tozzi A, Di Filippo M, DiNapoli V, Plattner F, Kansy JW, Benkovic SA, Huber JD, Miller DB, Greengard P, Calabresi P, Rosen CL, Bibb JA. Ischemic stroke injury is mediated by aberrant Cdk5. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8259-67. PMID 24920629 DOI: 10.1523/Jneurosci.4368-13.2014  0.61
2014 Heiman M, Kulicke R, Fenster RJ, Greengard P, Heintz N. Cell type-specific mRNA purification by translating ribosome affinity purification (TRAP). Nature Protocols. 9: 1282-91. PMID 24810037 DOI: 10.1038/Nprot.2014.085  0.751
2014 Arango-Lievano M, Schwarz JT, Vernov M, Wilkinson MB, Bradbury K, Feliz A, Marongiu R, Gelfand Y, Warner-Schmidt J, Nestler EJ, Greengard P, Russo SJ, Kaplitt MG. Cell-type specific expression of p11 controls cocaine reward. Biological Psychiatry. 76: 794-801. PMID 24725970 DOI: 10.1016/J.Biopsych.2014.02.012  0.782
2014 Svenningsson P, Berg L, Matthews D, Ionescu DF, Richards EM, Niciu MJ, Malinger A, Toups M, Manji H, Trivedi MH, Zarate CA, Greengard P. Preliminary evidence that early reduction in p11 levels in natural killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram. Molecular Psychiatry. 19: 962-4. PMID 24614495 DOI: 10.1038/Mp.2014.13  0.445
2014 Heiman M, Heilbut A, Francardo V, Kulicke R, Fenster RJ, Kolaczyk ED, Mesirov JP, Surmeier DJ, Cenci MA, Greengard P. Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia. Proceedings of the National Academy of Sciences of the United States of America. 111: 4578-83. PMID 24599591 DOI: 10.1073/Pnas.1401819111  0.801
2013 Tan CL, Plotkin JL, Venø MT, von Schimmelmann M, Feinberg P, Mann S, Handler A, Kjems J, Surmeier DJ, O'Carroll D, Greengard P, Schaefer A. MicroRNA-128 governs neuronal excitability and motor behavior in mice. Science (New York, N.Y.). 342: 1254-8. PMID 24311694 DOI: 10.1126/Science.1244193  0.653
2013 Borroto-Escuela DO, Flajolet M, Agnati LF, Greengard P, Fuxe K. Bioluminescence resonance energy transfer methods to study G protein-coupled receptor-receptor tyrosine kinase heteroreceptor complexes. Methods in Cell Biology. 117: 141-64. PMID 24143976 DOI: 10.1016/B978-0-12-408143-7.00008-6  0.313
2013 Tian Y, Chang JC, Fan EY, Flajolet M, Greengard P. Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy. Proceedings of the National Academy of Sciences of the United States of America. 110: 17071-6. PMID 24067654 DOI: 10.1073/pnas.1315110110  0.333
2013 Svenningsson P, Kim Y, Warner-Schmidt J, Oh YS, Greengard P. p11 and its role in depression and therapeutic responses to antidepressants. Nature Reviews. Neuroscience. 14: 673-80. PMID 24002251 DOI: 10.1038/Nrn3564  0.781
2013 Jordi E, Heiman M, Marion-Poll L, Guermonprez P, Cheng SK, Nairn AC, Greengard P, Girault JA. Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons. Proceedings of the National Academy of Sciences of the United States of America. 110: 9511-6. PMID 23690581 DOI: 10.1073/pnas.1307116110  0.597
2013 Oh YS, Gao P, Lee KW, Ceglia I, Seo JS, Zhang X, Ahn JH, Chait BT, Patel DJ, Kim Y, Greengard P. SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action. Cell. 152: 831-43. PMID 23415230 DOI: 10.1016/J.Cell.2013.01.014  0.665
2013 Rebholz H, Zhou M, Nairn AC, Greengard P, Flajolet M. Selective knockout of the casein kinase 2 in d1 medium spiny neurons controls dopaminergic function. Biological Psychiatry. 74: 113-21. PMID 23290496 DOI: 10.1016/j.biopsych.2012.11.013  0.541
2013 Eriksson TM, Alvarsson A, Stan TL, Zhang X, Hascup KN, Hascup ER, Kehr J, Gerhardt GA, Warner-Schmidt J, Arango-Lievano M, Kaplitt MG, Ogren SO, Greengard P, Svenningsson P. Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Molecular Psychiatry. 18: 1096-105. PMID 23032875 DOI: 10.1038/Mp.2012.130  0.78
2012 Liebmann T, Kruusmägi M, Sourial-Bassillious N, Bondar A, Svenningsson P, Flajolet M, Greengard P, Scott L, Brismar H, Aperia A. A noncanonical postsynaptic transport route for a GPCR belonging to the serotonin receptor family. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 17998-8008. PMID 23238716 DOI: 10.1523/JNEUROSCI.1804-12.2012  0.508
2012 Bettayeb K, Oumata N, Zhang Y, Luo W, Bustos V, Galons H, Greengard P, Meijer L, Flajolet M. Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 5115-23. PMID 22972917 DOI: 10.1096/Fj.12-212985  0.712
2012 Chan CS, Peterson JD, Gertler TS, Glajch KE, Quintana RE, Cui Q, Sebel LE, Plotkin JL, Shen W, Heiman M, Heintz N, Greengard P, Surmeier DJ. Strain-specific regulation of striatal phenotype in Drd2-eGFP BAC transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9124-32. PMID 22764222 DOI: 10.1523/Jneurosci.0229-12.2012  0.52
2012 Santini E, Feyder M, Gangarossa G, Bateup HS, Greengard P, Fisone G. Dopamine- and cAMP-regulated phosphoprotein of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin complex 1 (mTORC1) signaling in experimental parkinsonism. The Journal of Biological Chemistry. 287: 27806-12. PMID 22753408 DOI: 10.1074/Jbc.M112.388413  0.74
2012 Warner-Schmidt JL, Schmidt EF, Marshall JJ, Rubin AJ, Arango-Lievano M, Kaplitt MG, Ibañez-Tallon I, Heintz N, Greengard P. Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior. Proceedings of the National Academy of Sciences of the United States of America. 109: 11360-5. PMID 22733786 DOI: 10.1073/Pnas.1209293109  0.806
2012 Schmidt EF, Warner-Schmidt JL, Otopalik BG, Pickett SB, Greengard P, Heintz N. Identification of the cortical neurons that mediate antidepressant responses. Cell. 149: 1152-63. PMID 22632977 DOI: 10.1016/J.Cell.2012.03.038  0.723
2012 Davis MM, Olausson P, Greengard P, Taylor JR, Nairn AC. Regulator of calmodulin signaling knockout mice display anxiety-like behavior and motivational deficits. The European Journal of Neuroscience. 35: 300-8. PMID 22250817 DOI: 10.1111/j.1460-9568.2011.07956.x  0.704
2012 Kuroiwa M, Snyder GL, Shuto T, Fukuda A, Yanagawa Y, Benavides DR, Nairn AC, Bibb JA, Greengard P, Nishi A. Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex. Psychopharmacology. 219: 1065-79. PMID 21833500 DOI: 10.1007/S00213-011-2436-8  0.789
2011 Ahn JH, Kim Y, Kim HS, Greengard P, Nairn AC. Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56δ heterotrimeric form of protein phosphatase 2A. Plos One. 6: e26292. PMID 22046270 DOI: 10.1371/journal.pone.0026292  0.576
2011 Walaas SI, Hemmings HC, Greengard P, Nairn AC. Beyond the dopamine receptor: regulation and roles of serine/threonine protein phosphatases. Frontiers in Neuroanatomy. 5: 50. PMID 21904525 DOI: 10.3389/fnana.2011.00050  0.775
2011 Zhang Y, Kurup P, Xu J, Anderson GM, Greengard P, Nairn AC, Lombroso PJ. Reduced levels of the tyrosine phosphatase STEP block β amyloid-mediated GluA1/GluA2 receptor internalization. Journal of Neurochemistry. 119: 664-72. PMID 21883219 DOI: 10.1111/j.1471-4159.2011.07450.x  0.666
2011 Warner-Schmidt JL, Vanover KE, Chen EY, Marshall JJ, Greengard P. Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans. Proceedings of the National Academy of Sciences of the United States of America. 108: 9262-7. PMID 21518864 DOI: 10.1073/Pnas.1104836108  0.728
2011 Tian Y, Bustos V, Flajolet M, Greengard P. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 1934-42. PMID 21368103 DOI: 10.1096/Fj.10-175158  0.69
2011 Egeland M, Warner-Schmidt J, Greengard P, Svenningsson P. Co-expression of serotonin 5-HT(1B) and 5-HT(4) receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum. Neuropharmacology. 61: 442-50. PMID 21300076 DOI: 10.1016/j.neuropharm.2011.01.046  0.726
2011 Christoffel DJ, Golden SA, Dumitriu D, Robison AJ, Janssen WG, Ahn HF, Krishnan V, Reyes CM, Han MH, Ables JL, Eisch AJ, Dietz DM, Ferguson D, Neve RL, Greengard P, et al. IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 314-21. PMID 21209217 DOI: 10.1523/Jneurosci.4763-10.2011  0.794
2011 Warner-Schmidt JL, Vanover KE, Chen EY, Marshall JJ, Greengard P. Antidepressant effects of SSRIs are attenuated by anti-inflammatory drugs in mice and humans F1000research. 2. DOI: 10.7490/F1000Research.1460.1  0.405
2011 Egeland M, Warner-Schmidt J, Greengard P, Svenningsson P. P.2.b.019 Ablated neurogenic response to fluoxetine in female p11 knockout mice European Neuropsychopharmacology. 21: S378. DOI: 10.1016/S0924-977X(11)70607-1  0.725
2010 Wang H, Nong Y, Bazan F, Greengard P, Flajolet M. Norbin: A promising central nervous system regulator. Communicative & Integrative Biology. 3: 487-90. PMID 21331221 DOI: 10.4161/cib.3.6.12844  0.372
2010 Alexander B, Warner-Schmidt J, Eriksson T, Tamminga C, Arango-Lievano M, Arango-Llievano M, Ghose S, Vernov M, Stavarache M, Stavarche M, Musatov S, Flajolet M, Svenningsson P, Greengard P, Kaplitt MG. Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. Science Translational Medicine. 2: 54ra76. PMID 20962330 DOI: 10.1126/Scitranslmed.3001079  0.792
2010 Paillé V, Picconi B, Bagetta V, Ghiglieri V, Sgobio C, Di Filippo M, Viscomi MT, Giampà C, Fusco FR, Gardoni F, Bernardi G, Greengard P, Di Luca M, Calabresi P. Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14182-93. PMID 20962239 DOI: 10.1523/Jneurosci.2149-10.2010  0.323
2010 Zhang Y, Kurup P, Xu J, Carty N, Fernandez SM, Nygaard HB, Pittenger C, Greengard P, Strittmatter SM, Nairn AC, Lombroso PJ. Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model. Proceedings of the National Academy of Sciences of the United States of America. 107: 19014-9. PMID 20956308 DOI: 10.1073/pnas.1013543107  0.621
2010 Bateup HS, Santini E, Shen W, Birnbaum S, Valjent E, Surmeier DJ, Fisone G, Nestler EJ, Greengard P. Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors. Proceedings of the National Academy of Sciences of the United States of America. 107: 14845-50. PMID 20682746 DOI: 10.1073/Pnas.1009874107  0.797
2010 Bendor J, Lizardi-Ortiz JE, Westphalen RI, Brandstetter M, Hemmings HC, Sulzer D, Flajolet M, Greengard P. AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. The Embo Journal. 29: 2813-26. PMID 20664521 DOI: 10.1038/emboj.2010.154  0.564
2010 Warner-Schmidt JL, Chen EY, Zhang X, Marshall JJ, Morozov A, Svenningsson P, Greengard P. A role for p11 in the antidepressant action of brain-derived neurotrophic factor. Biological Psychiatry. 68: 528-35. PMID 20591415 DOI: 10.1016/J.Biopsych.2010.04.029  0.775
2010 Netzer WJ, Powell C, Nong Y, Blundell J, Wong L, Duff K, Flajolet M, Greengard P. Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model. Plos One. 5: e10943. PMID 20532168 DOI: 10.1371/Journal.Pone.0010943  0.514
2010 Hemmings HC, Greengard P. Positively active: how local anesthetics work. Anesthesiology. 113: 250-2. PMID 20526177 DOI: 10.1097/ALN.0b013e3181e32e84  0.424
2010 Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, ... ... Greengard P, et al. Climate change and the integrity of science. Science (New York, N.Y.). 328: 689-90. PMID 20448167 DOI: 10.1126/Science.328.5979.689  0.627
2010 Kurup P, Zhang Y, Xu J, Venkitaramani DV, Haroutunian V, Greengard P, Nairn AC, Lombroso PJ. Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 5948-57. PMID 20427654 DOI: 10.1523/JNEUROSCI.0157-10.2010  0.799
2010 Ceglia I, Kim Y, Nairn AC, Greengard P. Signaling pathways controlling the phosphorylation state of WAVE1, a regulator of actin polymerization. Journal of Neurochemistry. 114: 182-90. PMID 20403076 DOI: 10.1111/j.1471-4159.2010.06743.x  0.527
2010 Hara M, Fukui R, Hieda E, Kuroiwa M, Bateup HS, Kano T, Greengard P, Nishi A. Role of adrenoceptors in the regulation of dopamine/DARPP-32 signaling in neostriatal neurons. Journal of Neurochemistry. 113: 1046-59. PMID 20236221 DOI: 10.1111/J.1471-4159.2010.06668.X  0.735
2010 Egeland M, Warner-Schmidt J, Greengard P, Svenningsson P. Neurogenic effects of fluoxetine are attenuated in p11 (S100A10) knockout mice. Biological Psychiatry. 67: 1048-56. PMID 20227680 DOI: 10.1016/j.biopsych.2010.01.024  0.736
2010 Glausier JR, Maddox M, Hemmings HC, Nairn AC, Greengard P, Muly EC. Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex. Neuroscience. 167: 428-38. PMID 20156529 DOI: 10.1016/j.neuroscience.2010.02.014  0.699
2010 Zhou M, Rebholz H, Brocia C, Warner-Schmidt JL, Fienberg AA, Nairn AC, Greengard P, Flajolet M. Forebrain overexpression of CK1delta leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD. Proceedings of the National Academy of Sciences of the United States of America. 107: 4401-6. PMID 20145109 DOI: 10.1073/pnas.0915173107  0.755
2010 Zhang Y, Chen K, Baron M, Teylan MA, Kim Y, Song Z, Greengard P, Wong ST. A neurocomputational method for fully automated 3D dendritic spine detection and segmentation of medium-sized spiny neurons. Neuroimage. 50: 1472-84. PMID 20100579 DOI: 10.1016/j.neuroimage.2010.01.048  0.337
2010 Maze I, Covington HE, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E, Neve RL, Haggarty SJ, Ren Y, Sampath SC, Hurd YL, Greengard P, Tarakhovsky A, et al. Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science (New York, N.Y.). 327: 213-6. PMID 20056891 DOI: 10.1126/Science.1179438  0.781
2010 Porton B, Rodriguiz RM, Phillips LE, Gilbert JW, Feng J, Greengard P, Kao HT, Wetsel WC. Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear. Genes, Brain, and Behavior. 9: 257-68. PMID 20050925 DOI: 10.1111/J.1601-183X.2009.00555.X  0.472
2010 Valjent E, Bertran-Gonzalez J, Aubier B, Greengard P, Hervé D, Girault JA. Mechanisms of locomotor sensitization to drugs of abuse in a two-injection protocol. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 401-15. PMID 19759531 DOI: 10.1038/npp.2009.143  0.544
2010 Alexander B, Warner-Schmidt J, Eriksson T, Tamminga C, Arango-Lievano M, Ghose S, Vernov M, Stavarache M, Musatov S, Flajolet M, Svenningsson P, Greengard P, Kaplitt MG. Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens (Science Translational Medicine (2010) 2, (62er4)) Science Translational Medicine. 2. DOI: 10.1126/Scitranslmed.3001996  0.772
2010 Alexander B, Warner-Schmidt J, Eriksson T, Tamminga C, Arango-Llievano M, Ghose S, Vernov M, Stavarche M, Musatov S, Flajolet M, Svenningsson P, Greengard P, Kaplitt MG. Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens (Science Translational Medicine (2010) 2, (55er3)) Science Translational Medicine. 2. DOI: 10.1126/scitranslmed.3001841  0.772
2010 Egeland M, Warner-Schmidt J, Greengard P, Svenningsson P. P.1.006 Neurogenic and chronic behavioural effects of fluoxetine are attenuated in p11 KO mice European Neuropsychopharmacology. 20: S6-S7. DOI: 10.1016/S0924-977X(10)70009-2  0.728
2009 Wang H, Westin L, Nong Y, Birnbaum S, Bendor J, Brismar H, Nestler E, Aperia A, Flajolet M, Greengard P. Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling. Science (New York, N.Y.). 326: 1554-7. PMID 20007903 DOI: 10.1126/science.1178496  0.51
2009 Schaefer A, Sampath SC, Intrator A, Min A, Gertler TS, Surmeier DJ, Tarakhovsky A, Greengard P. Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron. 64: 678-91. PMID 20005824 DOI: 10.1016/J.Neuron.2009.11.019  0.523
2009 Zhang YW, Liu S, Zhang X, Li WB, Chen Y, Huang X, Sun L, Luo W, Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen SN, Greengard P, Liao FF, et al. A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation. Neuron. 64: 328-40. PMID 19914182 DOI: 10.1016/J.Neuron.2009.08.036  0.54
2009 Rebholz H, Nishi A, Liebscher S, Nairn AC, Flajolet M, Greengard P. CK2 negatively regulates Galphas signaling. Proceedings of the National Academy of Sciences of the United States of America. 106: 14096-101. PMID 19666609 DOI: 10.1073/Pnas.0906857106  0.509
2009 Hansen C, Howlin J, Tengholm A, Dyachok O, Vogel WF, Nairn AC, Greengard P, Andersson T. Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner. The Journal of Biological Chemistry. 284: 27533-43. PMID 19651774 DOI: 10.1074/Jbc.M109.048884  0.439
2009 Santini E, Heiman M, Greengard P, Valjent E, Fisone G. Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia. Science Signaling. 2: ra36. PMID 19622833 DOI: 10.1126/Scisignal.2000308  0.322
2009 McAvoy T, Zhou MM, Greengard P, Nairn AC. Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphology. Proceedings of the National Academy of Sciences of the United States of America. 106: 3531-6. PMID 19218462 DOI: 10.1073/pnas.0813263106  0.607
2009 Endo S, Shutoh F, Dinh TL, Okamoto T, Ikeda T, Suzuki M, Kawahara S, Yanagihara D, Sato Y, Yamada K, Sakamoto T, Kirino Y, Hartell NA, Yamaguchi K, Itohara S, ... ... Greengard P, et al. Dual involvement of G-substrate in motor learning revealed by gene deletion. Proceedings of the National Academy of Sciences of the United States of America. 106: 3525-30. PMID 19218432 DOI: 10.1073/Pnas.0813341106  0.481
2009 Warner-Schmidt JL, Flajolet M, Maller A, Chen EY, Qi H, Svenningsson P, Greengard P. Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1937-46. PMID 19211900 DOI: 10.1523/JNEUROSCI.5343-08.2009  0.756
2009 Kim Y, Teylan MA, Baron M, Sands A, Nairn AC, Greengard P. Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. 106: 2915-20. PMID 19202072 DOI: 10.1073/pnas.0813179106  0.436
2009 Santini E, Alcacer C, Cacciatore S, Heiman M, Hervé D, Greengard P, Girault JA, Valjent E, Fisone G. L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice. Journal of Neurochemistry. 108: 621-33. PMID 19187092 DOI: 10.1111/J.1471-4159.2008.05831.X  0.58
2009 Bertran-Gonzalez J, Håkansson K, Borgkvist A, Irinopoulou T, Brami-Cherrier K, Usiello A, Greengard P, Hervé D, Girault JA, Valjent E, Fisone G. Histone H3 phosphorylation is under the opposite tonic control of dopamine D2 and adenosine A2A receptors in striatopallidal neurons. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1710-20. PMID 19158668 DOI: 10.1038/Npp.2008.228  0.589
2009 da Cruz e Silva OA, Rebelo S, Vieira SI, Gandy S, da Cruz e Silva EF, Greengard P. Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C. Journal of Neurochemistry. 108: 319-30. PMID 19012746 DOI: 10.1111/J.1471-4159.2008.05770.X  0.813
2009 Doyle JP, Dougherty JD, Heiman M, Schmidt EF, Stevens TR, Ma G, Bupp S, Shrestha P, Shah RD, Doughty ML, Gong S, Greengard P, Heintz N. Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types (DOI:10.1016/j.cell.2008.10.029) Cell. 139: 1022. DOI: 10.1016/j.cell.2009.11.011  0.657
2008 Meyer DA, Richer E, Benkovic SA, Hayashi K, Kansy JW, Hale CF, Moy LY, Kim Y, O'Callaghan JP, Tsai LH, Greengard P, Nairn AC, Cowan CW, Miller DB, Antich P, et al. Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology. Proceedings of the National Academy of Sciences of the United States of America. 105: 18561-6. PMID 19017804 DOI: 10.1073/Pnas.0806078105  0.708
2008 Lagace DC, Benavides DR, Kansy JW, Mapelli M, Greengard P, Bibb JA, Eisch AJ. Cdk5 is essential for adult hippocampal neurogenesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 18567-71. PMID 19017796 DOI: 10.1073/pnas.0810137105  0.803
2008 Doyle JP, Dougherty JD, Heiman M, Schmidt EF, Stevens TR, Ma G, Bupp S, Shrestha P, Shah RD, Doughty ML, Gong S, Greengard P, Heintz N. Application of a translational profiling approach for the comparative analysis of CNS cell types. Cell. 135: 749-62. PMID 19013282 DOI: 10.1016/J.Cell.2008.10.029  0.691
2008 Heiman M, Schaefer A, Gong S, Peterson JD, Day M, Ramsey KE, Suárez-Fariñas M, Schwarz C, Stephan DA, Surmeier DJ, Greengard P, Heintz N. A translational profiling approach for the molecular characterization of CNS cell types. Cell. 135: 738-48. PMID 19013281 DOI: 10.1016/J.Cell.2008.10.028  0.545
2008 Flajolet M, Wang Z, Futter M, Shen W, Nuangchamnong N, Bendor J, Wallach I, Nairn AC, Surmeier DJ, Greengard P. FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity. Nature Neuroscience. 11: 1402-9. PMID 18953346 DOI: 10.1038/Nn.2216  0.641
2008 Gitler D, Cheng Q, Greengard P, Augustine GJ. Synapsin IIa controls the reserve pool of glutamatergic synaptic vesicles. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10835-43. PMID 18945891 DOI: 10.1523/JNEUROSCI.0924-08.2008  0.328
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2008 Muly EC, Nairn AC, Greengard P, Rainnie DG. Subcellular distribution of the Rho-GEF Lfc in primate prefrontal cortex: effect of neuronal activation. The Journal of Comparative Neurology. 508: 927-39. PMID 18399541 DOI: 10.1002/cne.21703  0.533
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2008 Zhang X, Andren PE, Greengard P, Svenningsson P. Evidence for a role of the 5-HT1B receptor and its adaptor protein, p11, in L-DOPA treatment of an animal model of Parkinsonism. Proceedings of the National Academy of Sciences of the United States of America. 105: 2163-8. PMID 18256188 DOI: 10.1073/pnas.0711839105  0.524
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2008 Glausier J, Smith Y, Howell L, Greengard P, Muly EC. DIFFERENTIAL LOCALIZATION OF PROTEIN PHOSPHATASE-1 (PP1) ISOFORMS AT AXOSPINOUS SYNAPSES: RESPONSE TO HALOPERIDOL AND COCAINE TREATMENT Schizophrenia Research. 102: 63. DOI: 10.1016/S0920-9964(08)70197-X  0.308
2007 Svenningsson P, Bateup H, Qi H, Takamiya K, Huganir RL, Spedding M, Roth BL, McEwen BS, Greengard P. Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine. The European Journal of Neuroscience. 26: 3509-17. PMID 18088278 DOI: 10.1111/J.1460-9568.2007.05952.X  0.805
2007 Kitaoka S, Furuyashiki T, Nishi A, Shuto T, Koyasu S, Matsuoka T, Miyasaka M, Greengard P, Narumiya S. Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 12900-7. PMID 18032663 DOI: 10.1523/Jneurosci.3257-07.2007  0.337
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2007 Siksou L, Rostaing P, Lechaire JP, Boudier T, Ohtsuka T, Fejtová A, Kao HT, Greengard P, Gundelfinger ED, Triller A, Marty S. Three-dimensional architecture of presynaptic terminal cytomatrix. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6868-77. PMID 17596435 DOI: 10.1523/Jneurosci.1773-07.2007  0.311
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2007 Hawasli AH, Benavides DR, Nguyen C, Kansy JW, Hayashi K, Chambon P, Greengard P, Powell CM, Cooper DC, Bibb JA. Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nature Neuroscience. 10: 880-6. PMID 17529984 DOI: 10.1038/Nn1914  0.808
2007 Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, Moulick K, Aguirre J, Wu N, Greengard P, Chiosis G. Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proceedings of the National Academy of Sciences of the United States of America. 104: 9511-6. PMID 17517623 DOI: 10.1073/Pnas.0701055104  0.388
2007 Wang X, Zeng W, Kim MS, Allen PB, Greengard P, Muallem S. Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors. The Embo Journal. 26: 2768-76. PMID 17464283 DOI: 10.1038/Sj.Emboj.7601701  0.306
2007 Sahlin C, Lord A, Magnusson K, Englund H, Almeida CG, Greengard P, Nyberg F, Gouras GK, Lannfelt L, Nilsson LN. The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase. Journal of Neurochemistry. 101: 854-62. PMID 17448150 DOI: 10.1111/J.1471-4159.2006.04443.X  0.57
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2007 Svenningsson P, Greengard P. p11 (S100A10)--an inducible adaptor protein that modulates neuronal functions. Current Opinion in Pharmacology. 7: 27-32. PMID 17085073 DOI: 10.1016/j.coph.2006.10.001  0.514
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2006 Zhang Y, Svenningsson P, Picetti R, Schlussman SD, Nairn AC, Ho A, Greengard P, Kreek MJ. Cocaine self-administration in mice is inversely related to phosphorylation at Thr34 (protein kinase A site) and Ser130 (kinase CK1 site) of DARPP-32. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2645-51. PMID 16525043 DOI: 10.1523/Jneurosci.3923-05.2006  0.615
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2006 Zachariou V, Sgambato-Faure V, Sasaki T, Svenningsson P, Berton O, Fienberg AA, Nairn AC, Greengard P, Nestler EJ. Phosphorylation of DARPP-32 at Threonine-34 is required for cocaine action. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 555-62. PMID 16123776 DOI: 10.1038/Sj.Npp.1300832  0.786
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2005 Uematsu K, Futter M, Hsieh-Wilson LC, Higashi H, Maeda H, Nairn AC, Greengard P, Nishi A. Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways. Journal of Neurochemistry. 95: 1642-52. PMID 16300646 DOI: 10.1111/J.1471-4159.2005.03491.X  0.746
2005 Almeida CG, Tampellini D, Takahashi RH, Greengard P, Lin MT, Snyder EM, Gouras GK. Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses. Neurobiology of Disease. 20: 187-98. PMID 16242627 DOI: 10.1016/J.Nbd.2005.02.008  0.727
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2005 Hamada M, Hendrick JP, Ryan GR, Kuroiwa M, Higashi H, Tanaka M, Nairn AC, Greengard P, Nishi A. Nicotine regulates DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of 32 kDa) phosphorylation at multiple sites in neostriatal neurons. The Journal of Pharmacology and Experimental Therapeutics. 315: 872-8. PMID 16040813 DOI: 10.1124/jpet.105.090852  0.494
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2005 Chergui K, Svenningsson P, Greengard P. Physiological role for casein kinase 1 in glutamatergic synaptic transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6601-9. PMID 16014721 DOI: 10.1523/JNEUROSCI.1082-05.2005  0.785
2005 Ryan XP, Alldritt J, Svenningsson P, Allen PB, Wu GY, Nairn AC, Greengard P. The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology. Neuron. 47: 85-100. PMID 15996550 DOI: 10.1016/j.neuron.2005.05.013  0.622
2005 Stenh C, Englund H, Lord A, Johansson AS, Almeida CG, Gellerfors P, Greengard P, Gouras GK, Lannfelt L, Nilsson LN. Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay. Annals of Neurology. 58: 147-50. PMID 15984012 DOI: 10.1002/Ana.20524  0.571
2005 Wang X, Zeng W, Soyombo AA, Tang W, Ross EM, Barnes AP, Milgram SL, Penninger JM, Allen PB, Greengard P, Muallem S. Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nature Cell Biology. 7: 405-11. PMID 15793568 DOI: 10.1038/Ncb1237  0.32
2005 Bordelon JR, Smith Y, Nairn AC, Colbran RJ, Greengard P, Muly EC. Differential localization of protein phosphatase-1alpha, beta and gamma1 isoforms in primate prefrontal cortex. Cerebral Cortex (New York, N.Y. : 1991). 15: 1928-37. PMID 15758197 DOI: 10.1093/cercor/bhi070  0.479
2005 Hilfiker S, Benfenati F, Doussau F, Nairn AC, Czernik AJ, Augustine GJ, Greengard P. Structural domains involved in the regulation of transmitter release by synapsins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2658-69. PMID 15758176 DOI: 10.1523/Jneurosci.4278-04.2005  0.57
2005 Futter M, Uematsu K, Bullock SA, Kim Y, Hemmings HC, Nishi A, Greengard P, Nairn AC. Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5). Proceedings of the National Academy of Sciences of the United States of America. 102: 3489-94. PMID 15728359 DOI: 10.1073/pnas.0409802102  0.66
2005 Takahashi S, Ohshima T, Cho A, Sreenath T, Iadarola MJ, Pant HC, Kim Y, Nairn AC, Brady RO, Greengard P, Kulkarni AB. Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. Proceedings of the National Academy of Sciences of the United States of America. 102: 1737-42. PMID 15665076 DOI: 10.1073/Pnas.0409456102  0.508
2005 Nishi A, Watanabe Y, Higashi H, Tanaka M, Nairn AC, Greengard P. Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. Proceedings of the National Academy of Sciences of the United States of America. 102: 1199-204. PMID 15657149 DOI: 10.1073/pnas.0409138102  0.504
2005 Valjent E, Pascoli V, Svenningsson P, Paul S, Enslen H, Corvol JC, Stipanovich A, Caboche J, Lombroso PJ, Nairn AC, Greengard P, Hervé D, Girault JA. Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Proceedings of the National Academy of Sciences of the United States of America. 102: 491-6. PMID 15608059 DOI: 10.1073/Pnas.0408305102  0.775
2004 Gitler D, Takagishi Y, Feng J, Ren Y, Rodriguiz RM, Wetsel WC, Greengard P, Augustine GJ. Different presynaptic roles of synapsins at excitatory and inhibitory synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 11368-80. PMID 15601943 DOI: 10.1523/Jneurosci.3795-04.2004  0.53
2004 Meijer L, Flajolet M, Greengard P. Pharmacological inhibitors of glycogen synthase kinase 3. Trends in Pharmacological Sciences. 25: 471-80. PMID 15559249 DOI: 10.1016/j.tips.2004.07.006  0.348
2004 Ouimet CC, Katona I, Allen P, Freund TF, Greengard P. Cellular and subcellular distribution of spinophilin, a PP1 regulatory protein that bundles F-actin in dendritic spines. The Journal of Comparative Neurology. 479: 374-88. PMID 15514983 DOI: 10.1002/Cne.20313  0.664
2004 Rakhilin SV, Olson PA, Nishi A, Starkova NN, Fienberg AA, Nairn AC, Surmeier DJ, Greengard P. A network of control mediated by regulator of calcium/calmodulin-dependent signaling. Science (New York, N.Y.). 306: 698-701. PMID 15499021 DOI: 10.1126/Science.1099961  0.688
2004 Nairn AC, Svenningsson P, Nishi A, Fisone G, Girault JA, Greengard P. The role of DARPP-32 in the actions of drugs of abuse. Neuropharmacology. 47: 14-23. PMID 15464122 DOI: 10.1016/J.Neuropharm.2004.05.010  0.738
2004 Lee SJ, Romeo RD, Svenningsson P, Campomanes CR, Allen PB, Greengard P, McEwen BS. Estradiol affects spinophilin protein differently in gonadectomized males and females. Neuroscience. 127: 983-8. PMID 15312910 DOI: 10.1016/j.neuroscience.2004.05.049  0.488
2004 Hamada M, Higashi H, Nairn AC, Greengard P, Nishi A. Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. Journal of Neurochemistry. 90: 1094-103. PMID 15312165 DOI: 10.1111/j.1471-4159.2004.02574.x  0.543
2004 Giovedì S, Darchen F, Valtorta F, Greengard P, Benfenati F. Synapsin is a novel Rab3 effector protein on small synaptic vesicles. II. Functional effects of the Rab3A-synapsin I interaction. The Journal of Biological Chemistry. 279: 43769-79. PMID 15265868 DOI: 10.1074/Jbc.M404168200  0.676
2004 Giovedì S, Vaccaro P, Valtorta F, Darchen F, Greengard P, Cesareni G, Benfenati F. Synapsin is a novel Rab3 effector protein on small synaptic vesicles. I. Identification and characterization of the synapsin I-Rab3 interactions in vitro and in intact nerve terminals. The Journal of Biological Chemistry. 279: 43760-8. PMID 15265865 DOI: 10.1074/Jbc.M403293200  0.677
2004 Wang H, Luo WJ, Zhang YW, Li YM, Thinakaran G, Greengard P, Xu H. Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components. The Journal of Biological Chemistry. 279: 40560-6. PMID 15247291 DOI: 10.1074/Jbc.M404345200  0.428
2004 Grossman SD, Futter M, Snyder GL, Allen PB, Nairn AC, Greengard P, Hsieh-Wilson LC. Spinophilin is phosphorylated by Ca2+/calmodulin-dependent protein kinase II resulting in regulation of its binding to F-actin. Journal of Neurochemistry. 90: 317-24. PMID 15228588 DOI: 10.1111/J.1471-4159.2004.02491.X  0.74
2004 Wang Q, Zhao J, Brady AE, Feng J, Allen PB, Lefkowitz RJ, Greengard P, Limbird LE. Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science (New York, N.Y.). 304: 1940-4. PMID 15218143 DOI: 10.1126/Science.1098274  0.595
2004 Girault JA, Greengard P. The neurobiology of dopamine signaling. Archives of Neurology. 61: 641-4. PMID 15148138 DOI: 10.1001/archneur.61.5.641  0.561
2004 Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P. Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. Proceedings of the National Academy of Sciences of the United States of America. 101: 7187-92. PMID 15107502 DOI: 10.1073/pnas.0401673101  0.478
2004 Knockaert M, Blondel M, Bach S, Leost M, Elbi C, Hager GL, Nagy SR, Han D, Denison M, Ffrench M, Ryan XP, Magiatis P, Polychronopoulos P, Greengard P, Skaltsounis L, et al. Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene. 23: 4400-12. PMID 15077192 DOI: 10.1038/Sj.Onc.1207535  0.381
2004 Gitler D, Xu Y, Kao HT, Lin D, Lim S, Feng J, Greengard P, Augustine GJ. Molecular determinants of synapsin targeting to presynaptic terminals. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3711-20. PMID 15071120 DOI: 10.1523/Jneurosci.5225-03.2004  0.506
2004 Chen G, Greengard P, Yan Z. Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. 101: 2596-600. PMID 14983054 DOI: 10.1073/Pnas.0308618100  0.586
2004 Lin TH, Huang YC, Chin ML, Chen YC, Jeng HH, Lin FM, Shiao MS, Horiuchi A, Greengard P, Nairn AC, Huang HB. 1H, 15N, and 13C resonance assignments of DARPP-32 (dopamine and cAMP-regulated phosphoprotein, Mr. 32,000)--a protein inhibitor of protein phosphatase-1. Journal of Biomolecular Nmr. 28: 413-4. PMID 14872138 DOI: 10.1023/B:JNMR.0000015358.20495.b8  0.517
2004 Chergui K, Svenningsson P, Greengard P. Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum. Proceedings of the National Academy of Sciences of the United States of America. 101: 2191-6. PMID 14769920 DOI: 10.1073/pnas.0308652100  0.8
2004 Polychronopoulos P, Magiatis P, Skaltsounis AL, Myrianthopoulos V, Mikros E, Tarricone A, Musacchio A, Roe SM, Pearl L, Leost M, Greengard P, Meijer L. Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. Journal of Medicinal Chemistry. 47: 935-46. PMID 14761195 DOI: 10.1021/jm031016d  0.339
2004 Svenningsson P, Nishi A, Fisone G, Girault JA, Nairn AC, Greengard P. DARPP-32: an integrator of neurotransmission. Annual Review of Pharmacology and Toxicology. 44: 269-96. PMID 14744247 DOI: 10.1146/Annurev.Pharmtox.44.101802.121415  0.743
2004 Muly EC, Smith Y, Allen P, Greengard P. Subcellular distribution of spinophilin immunolabeling in primate prefrontal cortex: localization to and within dendritic spines. The Journal of Comparative Neurology. 469: 185-97. PMID 14694533 DOI: 10.1002/cne.11001  0.396
2004 Svenningsson P, Tzavara E, Fienberg A, Nomikos G, Greengard P. P.1.10 Diverse psychotomimetics act through a common signaling pathway European Neuropsychopharmacology. 14: S9-S10. DOI: 10.1016/S0924-977X(04)90011-9  0.377
2004 Svenningsson P, Tzavara E, Carruthers R, Nomikos G, Greengard P. S.04.01 Diverse psychotomimetics act through a common signaling pathway European Neuropsychopharmacology. 14: S117-S118. DOI: 10.1016/S0924-977X(04)80012-9  0.445
2004 Stenh C, Englund H, Almeida C, Greengard P, Nilsson L, Gouras G, Lannfelt L. O4-02-04 The arctic APP mutation affects Aβ production and its site of cellular aggregation in Alzheimer's disease Neurobiology of Aging. 25: S76. DOI: 10.1016/S0197-4580(04)80259-8  0.504
2003 Fukui R, Svenningsson P, Matsuishi T, Higashi H, Nairn AC, Greengard P, Nishi A. Effect of methylphenidate on dopamine/DARPP signalling in adult, but not young, mice. Journal of Neurochemistry. 87: 1391-401. PMID 14713295 DOI: 10.1046/j.1471-4159.2003.02101.x  0.63
2003 Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, ... Greengard P, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chemistry & Biology. 10: 1255-66. PMID 14700633 DOI: 10.1016/j.chembiol.2003.11.010  0.331
2003 Watanabe T, da Cruz e Silva EF, Huang HB, Starkova N, Kwon YG, Horiuchi A, Greengard P, Nairn AC. Preparation and characterization of recombinant protein phosphatase 1. Methods in Enzymology. 366: 321-38. PMID 14674258 DOI: 10.1016/S0076-6879(03)66024-6  0.684
2003 Flajolet M, Rakhilin S, Wang H, Starkova N, Nuangchamnong N, Nairn AC, Greengard P. Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3. Proceedings of the National Academy of Sciences of the United States of America. 100: 16006-11. PMID 14663150 DOI: 10.1073/pnas.2136600100  0.484
2003 Svenningsson P, Tzavara ET, Carruthers R, Rachleff I, Wattler S, Nehls M, McKinzie DL, Fienberg AA, Nomikos GG, Greengard P. Diverse psychotomimetics act through a common signaling pathway. Science (New York, N.Y.). 302: 1412-5. PMID 14631045 DOI: 10.1126/science.1089681  0.569
2003 Snyder GL, Galdi S, Fienberg AA, Allen P, Nairn AC, Greengard P. Regulation of AMPA receptor dephosphorylation by glutamate receptor agonists. Neuropharmacology. 45: 703-13. PMID 14529709 DOI: 10.1016/S0028-3908(03)00319-8  0.528
2003 Netzer WJ, Dou F, Cai D, Veach D, Jean S, Li Y, Bornmann WG, Clarkson B, Xu H, Greengard P. Gleevec inhibits beta-amyloid production but not Notch cleavage. Proceedings of the National Academy of Sciences of the United States of America. 100: 12444-9. PMID 14523244 DOI: 10.1073/Pnas.1534745100  0.441
2003 Pozzi L, HÃ¥kansson K, Usiello A, Borgkvist A, Lindskog M, Greengard P, Fisone G. Opposite regulation by typical and atypical anti-psychotics of ERK1/2, CREB and Elk-1 phosphorylation in mouse dorsal striatum. Journal of Neurochemistry. 86: 451-9. PMID 12871586 DOI: 10.1046/J.1471-4159.2003.01851.X  0.734
2003 Nally RE, McNamara FN, Clifford JJ, Kinsella A, Tighe O, Croke DT, Fienberg AA, Greengard P, Waddington JL. Topographical Assessment of Ethological and Dopamine Receptor Agonist-Induced Behavioral Phenotype in Mutants with Congenic DARPP-32 'Knockout'. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 2055-63. PMID 12865890 DOI: 10.1038/sj.npp.1300259  0.342
2003 Sabo SL, Ikin AF, Buxbaum JD, Greengard P. The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5407-15. PMID 12843239 DOI: 10.1523/Jneurosci.23-13-05407.2003  0.793
2003 Bloom O, Evergren E, Tomilin N, Kjaerulff O, Löw P, Brodin L, Pieribone VA, Greengard P, Shupliakov O. Colocalization of synapsin and actin during synaptic vesicle recycling. The Journal of Cell Biology. 161: 737-47. PMID 12756235 DOI: 10.1083/jcb.200212140  0.753
2003 Chi P, Greengard P, Ryan TA. Synaptic vesicle mobilization is regulated by distinct synapsin I phosphorylation pathways at different frequencies. Neuron. 38: 69-78. PMID 12691665 DOI: 10.1016/S0896-6273(03)00151-X  0.73
2003 Picconi B, Centonze D, HÃ¥kansson K, Bernardi G, Greengard P, Fisone G, Cenci MA, Calabresi P. Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia. Nature Neuroscience. 6: 501-6. PMID 12665799 DOI: 10.1038/Nn1040  0.324
2003 Lindgren N, Usiello A, Goiny M, Haycock J, Erbs E, Greengard P, Hokfelt T, Borrelli E, Fisone G. Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites. Proceedings of the National Academy of Sciences of the United States of America. 100: 4305-9. PMID 12651945 DOI: 10.1073/Pnas.0730708100  0.521
2003 Kruse MS, Adachi S, Scott L, Holtbäck U, Greengard P, Aperia A, Brismar H. Recruitment of renal dopamine 1 receptors requires an intact microtubulin network. Pflã¼Gers Archiv : European Journal of Physiology. 445: 534-9. PMID 12634922 DOI: 10.1007/s00424-002-0899-5  0.33
2003 Kim YM, Watanabe T, Allen PB, Kim YM, Lee SJ, Greengard P, Nairn AC, Kwon YG. PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation. The Journal of Biological Chemistry. 278: 13819-28. PMID 12574161 DOI: 10.1074/jbc.M209621200  0.524
2003 Nishi A, Liu F, Matsuyama S, Hamada M, Higashi H, Nairn AC, Greengard P. Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling. Proceedings of the National Academy of Sciences of the United States of America. 100: 1322-7. PMID 12538871 DOI: 10.1073/pnas.0237126100  0.517
2003 Norrholm SD, Bibb JA, Nestler EJ, Ouimet CC, Taylor JR, Greengard P. Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5. Neuroscience. 116: 19-22. PMID 12535933 DOI: 10.1016/S0306-4522(02)00560-2  0.8
2003 Dou F, Netzer WJ, Tanemura K, Li F, Hartl FU, Takashima A, Gouras GK, Greengard P, Xu H. Chaperones increase association of tau protein with microtubules. Proceedings of the National Academy of Sciences of the United States of America. 100: 721-6. PMID 12522269 DOI: 10.1073/Pnas.242720499  0.649
2003 Endo S, Nairn AC, Greengard P, Ito M. Thr123 of rat G-substrate contributes to its action as a protein phosphatase inhibitor. Neuroscience Research. 45: 79-89. PMID 12507727 DOI: 10.1016/S0168-0102(02)00199-2  0.503
2003 Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu H. Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. The Journal of Biological Chemistry. 278: 3446-54. PMID 12435726 DOI: 10.1074/Jbc.M209065200  0.49
2003 Hsieh-Wilson LC, Benfenati F, Snyder GL, Allen PB, Nairn AC, Greengard P. Phosphorylation of spinophilin modulates its interaction with actin filaments. The Journal of Biological Chemistry. 278: 1186-94. PMID 12417592 DOI: 10.1074/Jbc.M205754200  0.763
2003 Svenningsson P, Tzavara E, Nomikos G, McEwen B, Greengard P. S.04.02 Biochemical modulation of AMPA receptor function by antidepressants European Neuropsychopharmacology. 13: S102-S103. DOI: 10.1016/S0924-977X(03)91610-5  0.466
2003 Norrholm S, Bibb J, Nestler E, Ouimet C, Taylor J, Greengard P. Corrigendum to “cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5” Neuroscience. 119: 619. DOI: 10.1016/S0306-4522(03)00155-6  0.807
2002 Flores-Hernández J, Cepeda C, Hernández-Echeagaray E, Calvert CR, Jokel ES, Fienberg AA, Greengard P, Levine MS. Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: role of D1 receptors and DARPP-32. Journal of Neurophysiology. 88: 3010-20. PMID 12466426 DOI: 10.1152/Jn.00361.2002  0.345
2002 Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, Beal MF, Xu H, Greengard P, Gouras GK. Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. The American Journal of Pathology. 161: 1869-79. PMID 12414533 DOI: 10.1016/S0002-9440(10)64463-X  0.665
2002 Pieribone VA, Porton B, Rendon B, Feng J, Greengard P, Kao HT. Expression of synapsin III in nerve terminals and neurogenic regions of the adult brain. The Journal of Comparative Neurology. 454: 105-14. PMID 12412137 DOI: 10.1002/Cne.10417  0.717
2002 Shupliakov O, Bloom O, Gustafsson JS, Kjaerulff O, Low P, Tomilin N, Pieribone VA, Greengard P, Brodin L. Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton. Proceedings of the National Academy of Sciences of the United States of America. 99: 14476-81. PMID 12381791 DOI: 10.1073/pnas.212381799  0.74
2002 Knockaert M, Greengard P, Meijer L. Pharmacological inhibitors of cyclin-dependent kinases. Trends in Pharmacological Sciences. 23: 417-25. PMID 12237154 DOI: 10.1016/S0165-6147(02)02071-0  0.322
2002 Grossman SD, Hsieh-Wilson LC, Allen PB, Nairn AC, Greengard P. The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines. Neuromolecular Medicine. 2: 61-9. PMID 12230305 DOI: 10.1385/Nmm:2:1:61  0.69
2002 Liu F, Virshup DM, Nairn AC, Greengard P. Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. The Journal of Biological Chemistry. 277: 45393-9. PMID 12223474 DOI: 10.1074/Jbc.M204499200  0.556
2002 Irwin N, Chao S, Goritchenko L, Horiuchi A, Greengard P, Nairn AC, Benowitz LI. Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19. Proceedings of the National Academy of Sciences of the United States of America. 99: 12427-31. PMID 12221279 DOI: 10.1073/Pnas.152457399  0.446
2002 Lindskog M, Svenningsson P, Pozzi L, Kim Y, Fienberg AA, Bibb JA, Fredholm BB, Nairn AC, Greengard P, Fisone G. Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature. 418: 774-8. PMID 12181566 DOI: 10.1038/Nature00817  0.806
2002 Menegon A, Verderio C, Leoni C, Benfenati F, Czernik AJ, Greengard P, Matteoli M, Valtorta F. Spatial and temporal regulation of Ca2+/calmodulin-dependent protein kinase II activity in developing neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7016-26. PMID 12177199 DOI: 10.1523/Jneurosci.22-16-07016.2002  0.709
2002 Albert KA, Hemmings HC, Adamo AI, Potkin SG, Akbarian S, Sandman CA, Cotman CW, Bunney WE, Greengard P. Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Archives of General Psychiatry. 59: 705-12. PMID 12150646 DOI: 10.1001/Archpsyc.59.8.705  0.511
2002 Alves SE, Hoskin E, Lee SJ, Brake WG, Ferguson D, Luine V, Allen PB, Greengard P, McEwen BS. Serotonin mediates CA1 spine density but is not crucial for ovarian steroid regulation of synaptic plasticity in the adult rat dorsal hippocampus. Synapse (New York, N.Y.). 45: 143-51. PMID 12112407 DOI: 10.1002/Syn.10093  0.489
2002 Gasparini L, Netzer WJ, Greengard P, Xu H. Does insulin dysfunction play a role in Alzheimer's disease? Trends in Pharmacological Sciences. 23: 288-93. PMID 12084635 DOI: 10.1016/S0165-6147(02)02037-0  0.469
2002 Nishi A, Bibb JA, Matsuyama S, Hamada M, Higashi H, Nairn AC, Greengard P. Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A. Journal of Neurochemistry. 81: 832-41. PMID 12065642 DOI: 10.1046/j.1471-4159.2002.00876.x  0.737
2002 Matsuyama S, Higashi H, Maeda H, Greengard P, Nishi A. Neurotensin regulates DARPP-32 thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors. Journal of Neurochemistry. 81: 325-34. PMID 12064480 DOI: 10.1046/j.1471-4159.2002.00822.x  0.408
2002 Feng J, Chi P, Blanpied TA, Xu Y, Magarinos AM, Ferreira A, Takahashi RH, Kao HT, McEwen BS, Ryan TA, Augustine GJ, Greengard P. Regulation of neurotransmitter release by synapsin III. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4372-80. PMID 12040043 DOI: 10.1523/Jneurosci.22-11-04372.2002  0.802
2002 Yan Z, Chi P, Bibb JA, Ryan TA, Greengard P. Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons. The Journal of Physiology. 540: 761-70. PMID 11986366 DOI: 10.1113/Jphysiol.2001.013376  0.789
2002 Kao HT, Song HJ, Porton B, Ming GL, Hoh J, Abraham M, Czernik AJ, Pieribone VA, Poo MM, Greengard P. A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth. Nature Neuroscience. 5: 431-7. PMID 11976703 DOI: 10.1038/nn840  0.732
2002 Zachariou V, Benoit-Marand M, Allen PB, Ingrassia P, Fienberg AA, Gonon F, Greengard P, Picciotto MR. Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or Inhibitor 1. Biological Psychiatry. 51: 612-20. PMID 11955461 DOI: 10.1016/S0006-3223(01)01318-X  0.746
2002 Yamagata Y, Jovanovic JN, Czernik AJ, Greengard P, Obata K. Bidirectional changes in synapsin I phosphorylation at MAP kinase-dependent sites by acute neuronal excitation in vivo. Journal of Neurochemistry. 80: 835-42. PMID 11948247 DOI: 10.1046/j.0022-3042.2001.00753.x  0.746
2002 Svenningsson P, Tzavara ET, Liu F, Fienberg AA, Nomikos GG, Greengard P. DARPP-32 mediates serotonergic neurotransmission in the forebrain. Proceedings of the National Academy of Sciences of the United States of America. 99: 3188-93. PMID 11880652 DOI: 10.1073/pnas.052712699  0.491
2002 Svenningsson P, Tzavara ET, Witkin JM, Fienberg AA, Nomikos GG, Greengard P. Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac). Proceedings of the National Academy of Sciences of the United States of America. 99: 3182-7. PMID 11880651 DOI: 10.1073/Pnas.052712799  0.532
2002 Greenfield JP, Leung LW, Cai D, Kaasik K, Gross RS, Rodriguez-Boulan E, Greengard P, Xu H. Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis. The Journal of Biological Chemistry. 277: 12128-36. PMID 11823458 DOI: 10.1074/Jbc.M110009200  0.433
2002 Reed TM, Repaske DR, Snyder GL, Greengard P, Vorhees CV. Phosphodiesterase 1B Knock-Out Mice Exhibit Exaggerated Locomotor Hyperactivity and DARPP-32 Phosphorylation in Response to Dopamine Agonists and Display Impaired Spatial Learning The Journal of Neuroscience. 22: 5188-5197. DOI: 10.1523/Jneurosci.22-12-05188.2002  0.331
2001 Greengard P. The neurobiology of dopamine signaling. Bioscience Reports. 21: 247-69. PMID 11892993 DOI: 10.1023/A:1013205230142  0.302
2001 Muly EC, Greengard P, Goldman-Rakic PS. Distribution of protein phosphatases-1 alpha and -1 gamma 1 and the D(1) dopamine receptor in primate prefrontal cortex: Evidence for discrete populations of spines. The Journal of Comparative Neurology. 440: 261-70. PMID 11745622 DOI: 10.1002/cne.1384  0.326
2001 Greengard P. The neurobiology of slow synaptic transmission. Science (New York, N.Y.). 294: 1024-30. PMID 11691979 DOI: 10.1126/science.294.5544.1024  0.34
2001 Chi P, Greengard P, Ryan TA. Synapsin dispersion and reclustering during synaptic activity. Nature Neuroscience. 4: 1187-93. PMID 11685225 DOI: 10.1038/Nn756  0.729
2001 Nairn AC, Greengard P. A novel cyclin provides a link between dopamine and RNA processing. Neuron. 32: 174-6. PMID 11683987 DOI: 10.1016/S0896-6273(01)00469-X  0.484
2001 Stafstrom-Davis CA, Ouimet CC, Feng J, Allen PB, Greengard P, Houpt TA. Impaired conditioned taste aversion learning in spinophilin knockout mice. Learning & Memory (Cold Spring Harbor, N.Y.). 8: 272-8. PMID 11584074 DOI: 10.1101/Lm.42101  0.651
2001 Liu F, Ma XH, Ule J, Bibb JA, Nishi A, DeMaggio AJ, Yan Z, Nairn AC, Greengard P. Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors. Proceedings of the National Academy of Sciences of the United States of America. 98: 11062-8. PMID 11572969 DOI: 10.1073/Pnas.191353898  0.798
2001 Yan R, Han P, Miao H, Greengard P, Xu H. The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate. The Journal of Biological Chemistry. 276: 36788-96. PMID 11466313 DOI: 10.1074/Jbc.M104350200  0.505
2001 Carr AN, Sutliff RL, Weber CS, Allen PB, Greengard P, de Lanerolle P, Kranias EG, Paul RJ. Is myosin phosphatase regulated in vivo by inhibitor-1? Evidence from inhibitor-1 knockout mice. The Journal of Physiology. 534: 357-66. PMID 11454956 DOI: 10.1111/J.1469-7793.2001.00357.X  0.38
2001 Calabresi P, Gubellini P, Picconi B, Centonze D, Pisani A, Bonsi P, Greengard P, Hipskind RA, Borrelli E, Bernardi G. Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogenous dopamine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5110-20. PMID 11438586 DOI: 10.1523/Jneurosci.21-14-05110.2001  0.412
2001 Sabo SL, Ikin AF, Buxbaum JD, Greengard P. The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement. The Journal of Cell Biology. 153: 1403-14. PMID 11425871 DOI: 10.1083/jcb.153.7.1403  0.786
2001 Huang HB, Chen YC, Horiuchi A, Tsai LH, Liu HT, Chyan CL, Hsieh MJ, Liu CK, Lin FM, Greengard P, Nairn AC, Shiao MS, Lin TH. Backbone 1H, 15N, and 13C resonance assignments of ARPP-19. Journal of Biomolecular Nmr. 19: 383-4. PMID 11370788 DOI: 10.1023/A:1011214512601  0.323
2001 Dulubova I, Horiuchi A, Snyder GL, Girault JA, Czernik AJ, Shao L, Ramabhadran R, Greengard P, Nairn AC. ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. Journal of Neurochemistry. 77: 229-38. PMID 11279279 DOI: 10.1046/j.1471-4159.2001.00191.x  0.692
2001 Bibb JA, Nishi A, O'Callaghan JP, Ule J, Lan M, Snyder GL, Horiuchi A, Saito T, Hisanaga S, Czernik AJ, Nairn AC, Greengard P. Phosphorylation of protein phosphatase inhibitor-1 by Cdk5. The Journal of Biological Chemistry. 276: 14490-7. PMID 11278334 DOI: 10.1074/jbc.M007197200  0.72
2001 Bibb JA, Chen J, Taylor JR, Svenningsson P, Nishi A, Snyder GL, Yan Z, Sagawa ZK, Ouimet CC, Nairn AC, Nestler EJ, Greengard P. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature. 410: 376-80. PMID 11268215 DOI: 10.1038/35066591  0.798
2001 Watanabe T, Huang HB, Horiuchi A, da Cruze Silva EF, Hsieh-Wilson L, Allen PB, Shenolikar S, Greengard P, Nairn AC. Protein phosphatase 1 regulation by inhibitors and targeting subunits. Proceedings of the National Academy of Sciences of the United States of America. 98: 3080-5. PMID 11248035 DOI: 10.1073/Pnas.051003898  0.69
2001 Brake WG, Alves SE, Dunlop JC, Lee SJ, Bulloch K, Allen PB, Greengard P, McEwen BS. Novel target sites for estrogen action in the dorsal hippocampus: an examination of synaptic proteins. Endocrinology. 142: 1284-9. PMID 11181546 DOI: 10.1210/Endo.142.3.8036  0.313
2001 Hilfiker S, Czernik AJ, Greengard P, Augustine GJ. Tonically active protein kinase A regulates neurotransmitter release at the squid giant synapse. The Journal of Physiology. 531: 141-6. PMID 11179398 DOI: 10.1111/j.1469-7793.2001.0141j.x  0.383
2001 Cheetham JJ, Hilfiker S, Benfenati F, Weber T, Greengard P, Czernik AJ. Identification of synapsin I peptides that insert into lipid membranes. The Biochemical Journal. 354: 57-66. PMID 11171079 DOI: 10.1042/0264-6021:3540057  0.659
2001 Lidow MS, Song ZM, Castner SA, Allen PB, Greengard P, Goldman-Rakic PS. Antipsychotic treatment induces alterations in dendrite- and spine-associated proteins in dopamine-rich areas of the primate cerebral cortex. Biological Psychiatry. 49: 1-12. PMID 11163774 DOI: 10.1016/S0006-3223(00)01058-1  0.32
2001 Leclerc S, Garnier M, Hoessel R, Marko D, Bibb JA, Snyder GL, Greengard P, Biernat J, Wu YZ, Mandelkow EM, Eisenbrand G, Meijer L. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? The Journal of Biological Chemistry. 276: 251-60. PMID 11013232 DOI: 10.1074/jbc.M002466200  0.641
2001 Jovanovic JN, Sihra TS, Nairn AC, Hemmings HC, Greengard P, Czernik AJ. Opposing Changes in Phosphorylation of Specific Sites in Synapsin I During Ca2+-Dependent Glutamate Release in Isolated Nerve Terminals The Journal of Neuroscience. 21: 7944-7953. DOI: 10.1523/Jneurosci.21-20-07944.2001  0.811
2001 Humeau Y, Doussau F, Vitiello F, Greengard P, Benfenati F, Poulain B. Synapsin Controls Both Reserve and Releasable Synaptic Vesicle Pools during Neuronal Activity and Short-Term Plasticity inAplysia The Journal of Neuroscience. 21: 4195-4206. DOI: 10.1523/Jneurosci.21-12-04195.2001  0.509
2001 Gasparini L, Gouras GK, Wang R, Gross RS, Beal MF, Greengard P, Xu H. Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling The Journal of Neuroscience. 21: 2561-2570. DOI: 10.1523/Jneurosci.21-08-02561.2001  0.661
2001 CHEETHAM JJ, HILFIKER S, BENFENATI F, WEBER T, GREENGARD P, CZERNIK AJ. Identification of synapsin I peptides that insert into lipid membranes Biochemical Journal. 354: 57-66. DOI: 10.1042/Bj3540057  0.675
2000 Calabresi P, Gubellini P, Centonze D, Picconi B, Bernardi G, Chergui K, Svenningsson P, Fienberg AA, Greengard P. Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 8443-51. PMID 11069952 DOI: 10.1523/Jneurosci.20-22-08443.2000  0.581
2000 Nishi A, Bibb JA, Snyder GL, Higashi H, Nairn AC, Greengard P. Amplification of dopaminergic signaling by a positive feedback loop. Proceedings of the National Academy of Sciences of the United States of America. 97: 12840-5. PMID 11050161 DOI: 10.1073/pnas.220410397  0.723
2000 Huang HB, Chen YC, Tsai LH, Wang H, Lin FM, Horiuchi A, Greengard P, Nairn AC, Shiao MS, Lin TH. Backbone 1H, 15N, and 13C resonance assignments of inhibitor-2 -- a protein inhibitor of protein phosphatase-1. Journal of Biomolecular Nmr. 17: 359-60. PMID 11014604 DOI: 10.1023/A:1008355428294  0.481
2000 Leost M, Schultz C, Link A, Wu YZ, Biernat J, Mandelkow EM, Bibb JA, Snyder GL, Greengard P, Zaharevitz DW, Gussio R, Senderowicz AM, Sausville EA, Kunick C, Meijer L. Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. European Journal of Biochemistry / Febs. 267: 5983-94. PMID 10998059 DOI: 10.1046/j.1432-1327.2000.01673.x  0.651
2000 Iijima K, Ando K, Takeda S, Satoh Y, Seki T, Itohara S, Greengard P, Kirino Y, Nairn AC, Suzuki T. Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5. Journal of Neurochemistry. 75: 1085-91. PMID 10936190 DOI: 10.1046/J.1471-4159.2000.0751085.X  0.641
2000 Feng J, Yan Z, Ferreira A, Tomizawa K, Liauw JA, Zhuo M, Allen PB, Ouimet CC, Greengard P. Spinophilin regulates the formation and function of dendritic spines. Proceedings of the National Academy of Sciences of the United States of America. 97: 9287-92. PMID 10922077 DOI: 10.1073/Pnas.97.16.9287  0.789
2000 Onofri F, Giovedi S, Kao HT, Valtorta F, Bongiorno Borbone L, De Camilli P, Greengard P, Benfenati F. Specificity of the binding of synapsin I to Src homology 3 domains. The Journal of Biological Chemistry. 275: 29857-67. PMID 10899172 DOI: 10.1074/Jbc.M006018200  0.702
2000 Caporaso GL, Bibb JA, Snyder GL, Valle C, Rakhilin S, Fienberg AA, Hemmings HC, Nairn AC, Greengard P. Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia. Neuropharmacology. 39: 1637-44. PMID 10854908 DOI: 10.1016/S0028-3908(99)00230-0  0.796
2000 Svenningsson P, Fienberg AA, Allen PB, Moine CL, Lindskog M, Fisone G, Greengard P, Fredholm BB. Dopamine D(1) receptor-induced gene transcription is modulated by DARPP-32. Journal of Neurochemistry. 75: 248-57. PMID 10854268 DOI: 10.1046/J.1471-4159.2000.0750248.X  0.656
2000 Bibb JA, Yan Z, Svenningsson P, Snyder GL, Pieribone VA, Horiuchi A, Nairn AC, Messer A, Greengard P. Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice. Proceedings of the National Academy of Sciences of the United States of America. 97: 6809-14. PMID 10829080 DOI: 10.1073/Pnas.120166397  0.802
2000 Flores-Hernandez J, Hernandez S, Snyder GL, Yan Z, Fienberg AA, Moss SJ, Greengard P, Surmeier DJ. D(1) dopamine receptor activation reduces GABA(A) receptor currents in neostriatal neurons through a PKA/DARPP-32/PP1 signaling cascade. Journal of Neurophysiology. 83: 2996-3004. PMID 10805695 DOI: 10.1152/Jn.2000.83.5.2996  0.756
2000 Walaas SI, Hilfiker S, Li L, Chin LS, Greengard P. Decrease in phorbol ester-induced potentiation of noradrenaline release in synapsin I-deficient mice. Synapse (New York, N.Y.). 36: 114-9. PMID 10767058 DOI: 10.1002/(Sici)1098-2396(200005)36:2<114::Aid-Syn4>3.0.Co;2-Q  0.614
2000 Näslund J, Haroutunian V, Mohs R, Davis KL, Davies P, Greengard P, Buxbaum JD. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. Jama. 283: 1571-7. PMID 10735393 DOI: 10.1001/Jama.283.12.1571  0.54
2000 Jovanovic JN, Czernik AJ, Fienberg AA, Greengard P, Sihra TS. Synapsins as mediators of BDNF-enhanced neurotransmitter release. Nature Neuroscience. 3: 323-9. PMID 10725920 DOI: 10.1038/73888  0.808
2000 Aizman O, Brismar H, Uhlén P, Zettergren E, Levey AI, Forssberg H, Greengard P, Aperia A. Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons. Nature Neuroscience. 3: 226-30. PMID 10700253 DOI: 10.1038/72929  0.345
2000 Svenningsson P, Lindskog M, Ledent C, Parmentier M, Greengard P, Fredholm BB, Fisone G. Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D1, dopamine D2, and adenosine A2A receptors. Proceedings of the National Academy of Sciences of the United States of America. 97: 1856-60. PMID 10677546 DOI: 10.1073/Pnas.97.4.1856  0.662
2000 Mani SK, Fienberg AA, O'Callaghan JP, Snyder GL, Allen PB, Dash PK, Moore AN, Mitchell AJ, Bibb J, Greengard P, O'Malley BW. Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice. Science (New York, N.Y.). 287: 1053-6. PMID 10669419 DOI: 10.1126/Science.287.5455.1053  0.584
2000 Gouras GK, Xu H, Gross RS, Greenfield JP, Hai B, Wang R, Greengard P. Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides. Proceedings of the National Academy of Sciences of the United States of America. 97: 1202-5. PMID 10655508 DOI: 10.1073/Pnas.97.3.1202  0.629
2000 Gouras GK, Tsai J, Naslund J, Vincent B, Edgar M, Checler F, Greenfield JP, Haroutunian V, Buxbaum JD, Xu H, Greengard P, Relkin NR. Intraneuronal Abeta42 accumulation in human brain. The American Journal of Pathology. 156: 15-20. PMID 10623648 DOI: 10.1016/S0002-9440(10)64700-1  0.746
2000 Snyder GL, Allen PB, Fienberg AA, Valle CG, Huganir RL, Nairn AC, Greengard P. Regulation of Phosphorylation of the GluR1 AMPA Receptor in the Neostriatum by Dopamine and Psychostimulants In Vivo The Journal of Neuroscience. 20: 4480-4488. DOI: 10.1523/JNEUROSCI.20-12-04480.2000  0.674
2000 Allen PB, Hvalby Ø, Jensen V, Errington ML, Ramsay M, Chaudhry FA, Bliss TVP, Storm-Mathisen J, Morris RGM, Andersen P, Greengard P. Protein Phosphatase-1 Regulation in the Induction of Long-Term Potentiation: Heterogeneous Molecular Mechanisms The Journal of Neuroscience. 20: 3537-3543. DOI: 10.1523/JNEUROSCI.20-10-03537.2000  0.351
1999 Allen PB, Hsieh-Wilson L, Yan Z, Feng J, Ouimet CC, Greengard P. Control of protein phosphatase I in the dendrite. Biochemical Society Transactions. 27: 543-6. PMID 10917638 DOI: 10.1042/Bst0270543  0.804
1999 Bibb JA, Snyder GL, Nishi A, Yan Z, Meijer L, Fienberg AA, Tsai LH, Kwon YT, Girault JA, Czernik AJ, Huganir RL, Hemmings HC, Nairn AC, Greengard P. Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature. 402: 669-71. PMID 10604473 DOI: 10.1038/45251  0.827
1999 Kao HT, Porton B, Hilfiker S, Stefani G, Pieribone VA, DeSalle R, Greengard P. Molecular evolution of the synapsin gene family. The Journal of Experimental Zoology. 285: 360-77. PMID 10578110 DOI: 10.1002/(Sici)1097-010X(19991215)285:4<360::Aid-Jez4>3.0.Co;2-3  0.554
1999 Greenfield JP, Xu H, Greengard P, Gandy S, Seeger M. Generation of the amyloid-beta peptide N terminus in Saccharomyces cerevisiae expressing human Alzheimer's amyloid-beta precursor protein. The Journal of Biological Chemistry. 274: 33843-6. PMID 10567340 DOI: 10.1074/Jbc.274.48.33843  0.403
1999 McAvoy T, Allen PB, Obaishi H, Nakanishi H, Takai Y, Greengard P, Nairn AC, Hemmings HC. Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation. Biochemistry. 38: 12943-9. PMID 10504266 DOI: 10.1021/Bi991227D  0.677
1999 Nishi A, Fisone G, Snyder GL, Dulubova I, Aperia A, Nairn AC, Greengard P. Regulation of Na+, K+-ATPase isoforms in rat neostriatum by dopamine and protein kinase C. Journal of Neurochemistry. 73: 1492-501. PMID 10501194 DOI: 10.1046/J.1471-4159.1999.0731492.X  0.522
1999 Yan Z, Feng J, Fienberg AA, Greengard P. D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons. Proceedings of the National Academy of Sciences of the United States of America. 96: 11607-12. PMID 10500224 DOI: 10.1073/Pnas.96.20.11607  0.676
1999 Hilfiker S, Pieribone VA, Nordstedt C, Greengard P, Czernik AJ. Regulation of synaptotagmin I phosphorylation by multiple protein kinases. Journal of Neurochemistry. 73: 921-32. PMID 10461881 DOI: 10.1046/j.1471-4159.1999.0730921.x  0.672
1999 Greengard P, Allen PB, Nairn AC. Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade. Neuron. 23: 435-47. PMID 10433257 DOI: 10.1016/S0896-6273(00)80798-9  0.49
1999 Nishi A, Snyder GL, Fienberg AA, Fisone G, Aperia A, Nairn AC, Greengard P. Requirement for DARPP-32 in mediating effect of dopamine D2 receptor activation. The European Journal of Neuroscience. 11: 2589-92. PMID 10383649 DOI: 10.1046/J.1460-9568.1999.00724.X  0.505
1999 Cheng SX, Aizman O, Nairn AC, Greengard P, Aperia A. [Ca2+]i determines the effects of protein kinases A and C on activity of rat renal Na+,K+-ATPase. The Journal of Physiology. 518: 37-46. PMID 10373687 DOI: 10.1111/J.1469-7793.1999.0037R.X  0.477
1999 Lindskog M, Svenningsson P, Fredholm B, Greengard P, Fisone G. Mu- and delta-opioid receptor agonists inhibit DARPP-32 phosphorylation in distinct populations of striatal projection neurons. The European Journal of Neuroscience. 11: 2182-6. PMID 10336688 DOI: 10.1046/J.1460-9568.1999.00597.X  0.689
1999 Lindskog M, Svenningsson P, Fredholm BB, Greengard P, Fisone G. Activation of dopamine D2 receptors decreases DARPP-32 phosphorylation in striatonigral and striatopallidal projection neurons via different mechanisms. Neuroscience. 88: 1005-8. PMID 10336115 DOI: 10.1016/S0306-4522(98)00411-4  0.693
1999 Isohara T, Horiuchi A, Watanabe T, Ando K, Czernik AJ, Uno I, Greengard P, Nairn AC, Suzuki T. Phosphorylation of the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein at Ser655 by a novel protein kinase. Biochemical and Biophysical Research Communications. 258: 300-5. PMID 10329382 DOI: 10.1006/Bbrc.1999.0637  0.669
1999 Fienberg AA, Nordstedt C, Belting HG, Czernik AJ, Nairn AC, Gandy S, Greengard P, Ruddle FH. Phylogenetically conserved CK-II phosphorylation site of the murine homeodomain protein Hoxb-6. The Journal of Experimental Zoology. 285: 76-84. PMID 10327653 DOI: 10.1002/(SICI)1097-010X(19990415)285:1<76::AID-JEZ9>3.0.CO;2-K  0.548
1999 Nishi A, Snyder GL, Nairn AC, Greengard P. Role of calcineurin and protein phosphatase-2A in the regulation of DARPP-32 dephosphorylation in neostriatal neurons. Journal of Neurochemistry. 72: 2015-21. PMID 10217279 DOI: 10.1046/j.1471-4159.1999.0722015.x  0.55
1999 Hilfiker S, Pieribone VA, Czernik AJ, Kao HT, Augustine GJ, Greengard P. Synapsins as regulators of neurotransmitter release. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 354: 269-79. PMID 10212475 DOI: 10.1098/rstb.1999.0378  0.649
1999 Yan Z, Hsieh-Wilson L, Feng J, Tomizawa K, Allen PB, Fienberg AA, Nairn AC, Greengard P. Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin. Nature Neuroscience. 2: 13-7. PMID 10195174 DOI: 10.1038/4516  0.816
1999 Hsieh-Wilson LC, Allen PB, Watanabe T, Nairn AC, Greengard P. Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1. Biochemistry. 38: 4365-73. PMID 10194355 DOI: 10.1021/Bi982900M  0.7
1999 Hiroi N, Fienberg AA, Haile CN, Alburges M, Hanson GR, Greengard P, Nestler EJ. Neuronal and behavioural abnormalities in striatal function in DARPP-32-mutant mice. The European Journal of Neuroscience. 11: 1114-8. PMID 10103106 DOI: 10.1046/J.1460-9568.1999.00570.X  0.727
1999 Sabo SL, Lanier LM, Ikin AF, Khorkova O, Sahasrabudhe S, Greengard P, Buxbaum JD. Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein. The Journal of Biological Chemistry. 274: 7952-7. PMID 10075692 DOI: 10.1074/jbc.274.12.7952  0.781
1999 Huang HB, Horiuchi A, Watanabe T, Shih SR, Tsay HJ, Li HC, Greengard P, Nairn AC. Characterization of the inhibition of protein phosphatase-1 by DARPP-32 and inhibitor-2. The Journal of Biological Chemistry. 274: 7870-8. PMID 10075680 DOI: 10.1074/jbc.274.12.7870  0.429
1999 Endo S, Suzuki M, Sumi M, Nairn AC, Morita R, Yamakawa K, Greengard P, Ito M. Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells. Proceedings of the National Academy of Sciences of the United States of America. 96: 2467-72. PMID 10051666 DOI: 10.1073/pnas.96.5.2467  0.454
1999 Watanabe T, Sukegawa J, Sukegawa I, Tomita S, Iijima K, Oguchi S, Suzuki T, Nairn AC, Greengard P. A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer's amyloid precursor protein. Journal of Neurochemistry. 72: 549-56. PMID 9930726 DOI: 10.1046/J.1471-4159.1999.0720549.X  0.668
1999 Mayerhofer A, Hemmings HC, Snyder GL, Greengard P, Boddien S, Berg U, Brucker C. Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro. The Journal of Clinical Endocrinology and Metabolism. 84: 257-64. PMID 9920093 DOI: 10.1210/Jcem.84.1.5378  0.561
1999 Greenfield JP, Tsai J, Gouras GK, Hai B, Thinakaran G, Checler F, Sisodia SS, Greengard P, Xu H. Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. Proceedings of the National Academy of Sciences of the United States of America. 96: 742-7. PMID 9892704 DOI: 10.1073/Pnas.96.2.742  0.633
1999 Ando K, Oishi M, Takeda S, Iijima K, Isohara T, Nairn AC, Kirino Y, Greengard P, Suzuki T. Role of Phosphorylation of Alzheimer’s Amyloid Precursor Protein during Neuronal Differentiation The Journal of Neuroscience. 19: 4421-4427. DOI: 10.1523/Jneurosci.19-11-04421.1999  0.669
1999 Cheng SXJ, Aizman O, Nairn AC, Greengard P, Aperia A. [Ca2+](i) determines the effects of protein kinases A and C on activity of rat renal Na+,K+-ATPase Journal of Physiology. 518: 37-46. DOI: 10.1111/j.1469-7793.1999.0037r.x  0.403
1999 Allen PB, Hsieh-Wilson L, Yan Z, Feng J, Benfenati F, Ouimet CC, Greengard P. Control of protein phosphate 1 in the dendrite Biochemical Society Transactions. 27: A72-A72. DOI: 10.1042/Bst027A072A  0.788
1998 Hilfiker S, Schweizer FE, Kao HT, Czernik AJ, Greengard P, Augustine GJ. Two sites of action for synapsin domain E in regulating neurotransmitter release. Nature Neuroscience. 1: 29-35. PMID 10195105 DOI: 10.1038/229  0.31
1998 Gouras GK, Xu H, Jovanovic JN, Buxbaum JD, Wang R, Greengard P, Relkin NR, Gandy S. Generation and regulation of beta-amyloid peptide variants by neurons. Journal of Neurochemistry. 71: 1920-5. PMID 9798916 DOI: 10.1046/J.1471-4159.1998.71051920.X  0.795
1998 Ouimet CC, Langley-Gullion KC, Greengard P. Quantitative immunocytochemistry of DARPP-32-expressing neurons in the rat caudatoputamen. Brain Research. 808: 8-12. PMID 9795103 DOI: 10.1016/S0006-8993(98)00724-0  0.66
1998 Schiffmann SN, Desdouits F, Menu R, Greengard P, Vincent JD, Vanderhaeghen JJ, Girault JA. Modulation of the voltage-gated sodium current in rat striatal neurons by DARPP-32, an inhibitor of protein phosphatase. The European Journal of Neuroscience. 10: 1312-20. PMID 9749785 DOI: 10.1046/J.1460-9568.1998.00142.X  0.589
1998 Fienberg AA, Hiroi N, Mermelstein PG, Song W, Snyder GL, Nishi A, Cheramy A, O'Callaghan JP, Miller DB, Cole DG, Corbett R, Haile CN, Cooper DC, Onn SP, Grace AA, ... ... Greengard P, et al. DARPP-32: regulator of the efficacy of dopaminergic neurotransmission. Science (New York, N.Y.). 281: 838-42. PMID 9694658 DOI: 10.1126/Science.281.5378.838  0.812
1998 Greengard P, Nairn AC, Girault JA, Ouimet CC, Snyder GL, Fisone G, Allen PB, Fienberg A, Nishi A. The DARPP-32/protein phosphatase-1 cascade: a model for signal integration. Brain Research. Brain Research Reviews. 26: 274-84. PMID 9651542 DOI: 10.1016/S0165-0173(97)00057-X  0.739
1998 Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, Mazzarelli L, Fried G, Jovanovic JN, Seeger M, Relkin NR, Liao F, Checler F, Buxbaum JD, Chait BT, Thinakaran G, ... ... Greengard P, et al. Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nature Medicine. 4: 447-51. PMID 9546791 DOI: 10.1038/Nm0498-447  0.747
1998 Kao HT, Porton B, Czernik AJ, Feng J, Yiu G, Häring M, Benfenati F, Greengard P. A third member of the synapsin gene family. Proceedings of the National Academy of Sciences of the United States of America. 95: 4667-72. PMID 9539796 DOI: 10.1073/Pnas.95.8.4667  0.589
1998 Svenningsson P, Lindskog M, Rognoni F, Fredholm BB, Greengard P, Fisone G. Activation of adenosine A2A and dopamine D1 receptors stimulates cyclic AMP-dependent phosphorylation of DARPP-32 in distinct populations of striatal projection neurons. Neuroscience. 84: 223-8. PMID 9522376 DOI: 10.1016/S0306-4522(97)00510-1  0.709
1998 Allen PB, Kwon YG, Nairn AC, Greengard P. Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit. The Journal of Biological Chemistry. 273: 4089-95. PMID 9461602 DOI: 10.1074/jbc.273.7.4089  0.526
1998 Desdouits F, Siciliano JC, Nairn AC, Greengard P, Girault JA. Dephosphorylation of Ser-137 in DARPP-32 by protein phosphatases 2A and 2C: different roles in vitro and in striatonigral neurons. The Biochemical Journal. 330: 211-6. PMID 9461512 DOI: 10.1042/BJ3300211  0.691
1998 Desdouits-Magnen J, Desdouits F, Takeda S, Syu LJ, Saltiel AR, Buxbaum JD, Czernik AJ, Nairn AC, Greengard P. Regulation of secretion of Alzheimer amyloid precursor protein by the mitogen-activated protein kinase cascade. Journal of Neurochemistry. 70: 524-30. PMID 9453546 DOI: 10.1046/J.1471-4159.1998.70020524.X  0.708
1998 Snyder GL, Fienberg AA, Huganir RL, Greengard P. A Dopamine/D1 Receptor/Protein Kinase A/Dopamine- and cAMP-Regulated Phosphoprotein (Mr32 kDa)/Protein Phosphatase-1 Pathway Regulates Dephosphorylation of the NMDA Receptor The Journal of Neuroscience. 18: 10297-10303. DOI: 10.1523/JNEUROSCI.18-24-10297.1998  0.59
1998 Meredith JM, Moffatt CA, Auger AP, Snyder GL, Greengard P, Blaustein JD. Mating-Related Stimulation Induces Phosphorylation of Dopamine- and Cyclic AMP-Regulated Phosphoprotein-32 in Progestin Receptor-Containing Areas in the Female Rat Brain The Journal of Neuroscience. 18: 10189-10195. DOI: 10.1523/Jneurosci.18-23-10189.1998  0.368
1998 Fisone G, Snyder GL, Aperia A, Greengard P. Na+,K+-ATPase Phosphorylation in the Choroid Plexus: Synergistic Regulation by Serotonin/Protein Kinase C and Isoproterenol/cAMP-PK/PP-1 Pathways Molecular Medicine. 4: 258-265. DOI: 10.1007/Bf03401922  0.367
1998 Ferreira A, Chin L, Li L, Lanier LM, Kosik KS, Greengard P. Distinct Roles of Synapsin I and Synapsin II during Neuronal Development Molecular Medicine. 4: 22-28. DOI: 10.1007/Bf03401726  0.345
1997 Cheng XJ, Höög JO, Nairn AC, Greengard P, Aperia A. Regulation of rat Na-K-ATPase activity by PKC is modulated by state of phosphorylation of Ser-943 by PKA. American Journal of Physiology. Cell Physiology. 273: C1981-C1986. PMID 29585085 DOI: 10.1152/ajpcell.1997.273.6.C1981  0.453
1997 Nielander HB, Onofri F, Schaeffer E, Menegon A, Fesce R, Valtorta F, Greengard P, Benfenati F. Phosphorylation-dependent effects of synapsin IIa on actin polymerization and network formation. The European Journal of Neuroscience. 9: 2712-22. PMID 9517476 DOI: 10.1111/J.1460-9568.1997.Tb01700.X  0.667
1997 Vaccaro P, Dente L, Onofri F, Zucconi A, Martinelli S, Valtorta F, Greengard P, Cesareni G, Benfenati F. Anti-synapsin monoclonal antibodies: epitope mapping and inhibitory effects on phosphorylation and Grb2 binding. Brain Research. Molecular Brain Research. 52: 1-16. PMID 9450672 DOI: 10.1016/S0169-328X(97)00219-2  0.683
1997 Stefani G, Onofri F, Valtorta F, Vaccaro P, Greengard P, Benfenati F. Kinetic analysis of the phosphorylation-dependent interactions of synapsin I with rat brain synaptic vesicles. The Journal of Physiology. 504: 501-15. PMID 9401959 DOI: 10.1111/J.1469-7793.1997.501Bd.X  0.693
1997 Schnabel R, Metzger M, Jiang S, Hemmings HC, Greengard P, Braun K. Localization of dopamine D1 receptors and dopaminoceptive neurons in the chick forebrain. The Journal of Comparative Neurology. 388: 146-68. PMID 9364244 DOI: 10.1002/(SICI)1096-9861(19971110)388:1<146::AID-CNE10>3.0.CO;2-T  0.56
1997 Onofri F, Giovedì S, Vaccaro P, Czernik AJ, Valtorta F, De Camilli P, Greengard P, Benfenati F. Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 94: 12168-73. PMID 9342381 DOI: 10.1073/Pnas.94.22.12168  0.73
1997 Allen PB, Ouimet CC, Greengard P. Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. Proceedings of the National Academy of Sciences of the United States of America. 94: 9956-61. PMID 9275233 DOI: 10.1073/pnas.94.18.9956  0.655
1997 Belusa R, Wang ZM, Matsubara T, Sahlgren B, Dulubova I, Nairn AC, Ruoslahti E, Greengard P, Aperia A. Mutation of the protein kinase C phosphorylation site on rat alpha1 Na+,K+-ATPase alters regulation of intracellular Na+ and pH and influences cell shape and adhesiveness. The Journal of Biological Chemistry. 272: 20179-84. PMID 9242694 DOI: 10.1074/jbc.272.32.20179  0.479
1997 Langley KC, Bergson C, Greengard P, Ouimet CC. Co-localization of the D1 dopamine receptor in a subset of DARPP-32-containing neurons in rat caudate-putamen. Neuroscience. 78: 977-83. PMID 9174066 DOI: 10.1016/S0306-4522(96)00583-0  0.654
1997 Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, George-Hyslop PS, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proceedings of the National Academy of Sciences of the United States of America. 94: 5090-4. PMID 9144195 DOI: 10.1073/Pnas.94.10.5090  0.775
1997 Kwon YG, Lee SY, Choi Y, Greengard P, Nairn AC. Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase. Proceedings of the National Academy of Sciences of the United States of America. 94: 2168-73. PMID 9122166 DOI: 10.1073/Pnas.94.6.2168  0.479
1997 Suzuki T, Ando K, Isohara T, Oishi M, Lim GS, Satoh Y, Wasco W, Tanzi RE, Nairn AC, Greengard P, Gandy SE, Kirino Y. Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. Biochemistry. 36: 4643-9. PMID 9109675 DOI: 10.1021/Bi962618K  0.703
1997 Xu H, Sweeney D, Wang R, Thinakaran G, Lo AC, Sisodia SS, Greengard P, Gandy S. Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. Proceedings of the National Academy of Sciences of the United States of America. 94: 3748-52. PMID 9108049 DOI: 10.1073/Pnas.94.8.3748  0.394
1997 Kwon YG, Huang HB, Desdouits F, Girault JA, Greengard P, Nairn AC. Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 94: 3536-41. PMID 9108011 DOI: 10.1073/PNAS.94.8.3536  0.63
1997 Huang HB, Horiuchi A, Goldberg J, Greengard P, Nairn AC. Site-directed mutagenesis of amino acid residues of protein phosphatase 1 involved in catalysis and inhibitor binding. Proceedings of the National Academy of Sciences of the United States of America. 94: 3530-5. PMID 9108010 DOI: 10.1073/pnas.94.8.3530  0.405
1997 Nowicki S, Chen SL, Aizman O, Cheng XJ, Li D, Nowicki C, Nairn A, Greengard P, Aperia A. 20-Hydroxyeicosa-tetraenoic acid (20 HETE) activates protein kinase C. Role in regulation of rat renal Na+,K+-ATPase. The Journal of Clinical Investigation. 99: 1224-30. PMID 9077530 DOI: 10.1172/JCI119279  0.415
1997 Nishi A, Snyder GL, Greengard P. Bidirectional Regulation of DARPP-32 Phosphorylation by Dopamine The Journal of Neuroscience. 17: 8147-8155. DOI: 10.1523/JNEUROSCI.17-21-08147.1997  0.372
1997 Oishi M, Nairn AC, Czernik AJ, Lim GS, Isohara T, Gandy SE, Greengard P, Suzuki T. The Cytoplasmic Domain of Alzheimer’s Amyloid Precursor Protein Is Phosphorylated at Thr654, Ser655, and Thr668 in Adult Rat Brain and Cultured Cells Molecular Medicine. 3: 111-123. DOI: 10.1007/Bf03401803  0.735
1996 Ferreira A, Li L, Chin LS, Greengard P, Kosik KS. Postsynaptic element contributes to the delay in synaptogenesis in synapsin I-deficient neurons Molecular and Cellular Neurosciences. 8: 286-299. PMID 9026316 DOI: 10.1006/Mcne.1996.0064  0.327
1996 Kaplitt M, Gouras GK, Makimura H, Jovanovic J, Sweeney D, Greengard P, Relkin NR, Gandy S. Apolipoprotein E, A beta-amyloid, and the molecular pathology of Alzheimer's disease. Therapeutic implications. Annals of the New York Academy of Sciences. 802: 42-9. PMID 8993483 DOI: 10.1111/J.1749-6632.1996.Tb32597.X  0.772
1996 Ikin AF, Annaert WG, Takei K, De Camilli P, Jahn R, Greengard P, Buxbaum JD. Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway. The Journal of Biological Chemistry. 271: 31783-6. PMID 8943215 DOI: 10.1074/jbc.271.50.31783  0.726
1996 Lu B, Czernik AJ, Popov S, Wang T, Poo MM, Greengard P. Expression of synapsin I correlates with maturation of the neuromuscular synapse. Neuroscience. 74: 1087-97. PMID 8895877 DOI: 10.1016/0306-4522(96)00187-X  0.539
1996 Smith GD, Wolf DP, Trautman KC, da Cruz e Silva EF, Greengard P, Vijayaraghavan S. Primate sperm contain protein phosphatase 1, a biochemical mediator of motility. Biology of Reproduction. 54: 719-27. PMID 8835396 DOI: 10.1095/Biolreprod54.3.719  0.652
1996 Vijayaraghavan S, Stephens DT, Trautman K, Smith GD, Khatra B, da Cruz e Silva EF, Greengard P. Sperm motility development in the epididymis is associated with decreased glycogen synthase kinase-3 and protein phosphatase 1 activity. Biology of Reproduction. 54: 709-18. PMID 8835395 DOI: 10.1095/Biolreprod54.3.709  0.665
1996 Logvinenko NS, Dulubova I, Fedosova N, Larsson SH, Nairn AC, Esmann M, Greengard P, Aperia A. Phosphorylation by protein kinase C of serine-23 of the alpha-1 subunit of rat Na+,K(+)-ATPase affects its conformational equilibrium. Proceedings of the National Academy of Sciences of the United States of America. 93: 9132-7. PMID 8799166 DOI: 10.1073/PNAS.93.17.9132  0.458
1996 Desdouits F, Buxbaum JD, Desdouits-Magnen J, Nairn AC, Greengard P. Amyloid beta peptide formation in cell-free preparations. Regulation by protein kinase C, calmodulin, and calcineurin. The Journal of Biological Chemistry. 271: 24670-4. PMID 8798734 DOI: 10.1074/jbc.271.40.24670  0.691
1996 Ryan TA, Li L, Chin LS, Greengard P, Smith SJ. Synaptic vesicle recycling in synapsin I knock-out mice. The Journal of Cell Biology. 134: 1219-27. PMID 8794863 DOI: 10.1083/JCB.134.5.1219  0.704
1996 Xu H, Sweeney D, Greengard P, Gandy S. Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system. Proceedings of the National Academy of Sciences of the United States of America. 93: 4081-4. PMID 8633020 DOI: 10.1073/Pnas.93.9.4081  0.454
1996 Buxbaum JD, Greengard P. Regulation of APP processing by intra- and intercellular signals. Annals of the New York Academy of Sciences. 777: 327-31. PMID 8624108 DOI: 10.1111/j.1749-6632.1996.tb34441.x  0.583
1996 Jovanovic JN, Benfenati F, Siow YL, Sihra TS, Sanghera JS, Pelech SL, Greengard P, Czernik AJ. Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions. Proceedings of the National Academy of Sciences of the United States of America. 93: 3679-83. PMID 8622996 DOI: 10.1073/Pnas.93.8.3679  0.719
1996 Qian Y, Chao DS, Santillano DR, Cornwell TL, Nairn AC, Greengard P, Lincoln TM, Bredt DS. cGMP-Dependent Protein Kinase in Dorsal Root Ganglion: Relationship with Nitric Oxide Synthase and Nociceptive Neurons The Journal of Neuroscience. 16: 3130-3138. DOI: 10.1523/Jneurosci.16-10-03130.1996  0.527
1996 Watanabe T, Suzuki T, Sukegawa J, Sukegawa I, Nairn A, Greengard P. 387 Identification of a protein which interacts with the cytoplasmic domain of the Alzheimer amyloid protein Precursor Neurobiology of Aging. 17: S97. DOI: 10.1016/S0197-4580(96)80389-7  0.574
1996 Buxbaum J, Desdouits F, Desdouits-Magnen J, Ikin A, Luo Y, Sabo S, Sukegawa I, Takeda S, Watanabe T, Greengard P. 176 Non-protease approaches to modulating APP processing: is there therapeutic relevance? Neurobiology of Aging. 17: S45. DOI: 10.1016/S0197-4580(96)80178-3  0.765
1996 Gandy S, Xu H, Seeger M, Desdouits F, Sweeney D, Jaffe A, Toran-Allerand D, Frail D, Greengard P. 21 Regulated cleavage of amyloid-β precursor: Basic and clinical aspects Neurobiology of Aging. 17: S6. DOI: 10.1016/S0197-4580(96)80023-6  0.37
1996 Kao H, Stefani G, Han H, Pieribone V, Greengard P. Synapsin isoforms from primitive vertebrates: Evolutionary and functional significance Biological Psychiatry. 39: 594. DOI: 10.1016/0006-3223(96)84267-3  0.517
1996 Zhou Z, Smith JD, Greengard P, Gandy S. Alzheimer Amyloid-β Peptide Forms Denaturant-Resistant Complex with Type ε3 but Not Type ε4 Isoform of Native Apolipoprotein E Molecular Medicine. 2: 175-180. DOI: 10.1007/BF03401614  0.505
1995 Ceccaldi PE, Grohovaz F, Benfenati F, Chieregatti E, Greengard P, Valtorta F. Dephosphorylated synapsin I anchors synaptic vesicles to actin cytoskeleton: an analysis by videomicroscopy. The Journal of Cell Biology. 128: 905-12. PMID 7876313 DOI: 10.1083/Jcb.128.5.905  0.649
1995 Fisone G, Snyder GL, Fryckstedt J, Caplan MJ, Aperia A, Greengard P. Na+,K(+)-ATPase in the choroid plexus. Regulation by serotonin/protein kinase C pathway. The Journal of Biological Chemistry. 270: 2427-30. PMID 7852300 DOI: 10.1074/Jbc.270.6.2427  0.343
1995 Desdouits F, Cheetham JJ, Huang HB, Kwon YG, da Cruz e Silva EF, Denefle P, Ehrlich ME, Nairn AC, Greengard P, Girault JA. Mechanism of inhibition of protein phosphatase 1 by DARPP-32: studies with recombinant DARPP-32 and synthetic peptides. Biochemical and Biophysical Research Communications. 206: 652-8. PMID 7826384 DOI: 10.1006/bbrc.1995.1092  0.805
1995 Pieribone VA, Shupliakov O, Brodin L, Hilfiker-Rothenfluh S, Czernik AJ, Greengard P. Distinct pools of synaptic vesicles in neurotransmitter release. Nature. 375: 493-7. PMID 7777058 DOI: 10.1038/375493a0  0.588
1995 Fried G, Han HQ, Meister B, Hökfelt T, Greengard P. Laminin and neuropeptide Y are increased by synapsin transfection in cultured NG108-15 neuroblastoma/glioma hybrid cells. Journal of Neurochemistry. 64: 2674-80. PMID 7760047 DOI: 10.1046/j.1471-4159.1995.64062674.x  0.339
1995 Valtorta F, Iezzi N, Benfenati F, Lu B, Poo MM, Greengard P. Accelerated structural maturation induced by synapsin I at developing neuromuscular synapses of Xenopus laevis. The European Journal of Neuroscience. 7: 261-70. PMID 7757263 DOI: 10.1111/J.1460-9568.1995.Tb01062.X  0.773
1995 Ouimet CC, da Cruz e Silva EF, Greengard P. The alpha and gamma 1 isoforms of protein phosphatase 1 are highly and specifically concentrated in dendritic spines. Proceedings of the National Academy of Sciences of the United States of America. 92: 3396-400. PMID 7724573 DOI: 10.1073/PNAS.92.8.3396  0.759
1995 Desdouits F, Cohen D, Nairn AC, Greengard P, Girault JA. Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase I in vitro and in vivo. The Journal of Biological Chemistry. 270: 8772-8. PMID 7721783 DOI: 10.1074/jbc.270.15.8772  0.688
1995 Desdouits F, Siciliano JC, Greengard P, Girault JA. Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurin. Proceedings of the National Academy of Sciences of the United States of America. 92: 2682-5. PMID 7708705 DOI: 10.1073/PNAS.92.7.2682  0.557
1995 Yamagata Y, Obata K, Greengard P, Czernik AJ. Increase in synapsin I phosphorylation implicates a presynaptic component in septal kindling. Neuroscience. 64: 1-4. PMID 7708197 DOI: 10.1016/0306-4522(94)00492-N  0.35
1995 Goldberg J, Huang HB, Kwon YG, Greengard P, Nairn AC, Kuriyan J. Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature. 376: 745-53. PMID 7651533 DOI: 10.1038/376745A0  0.493
1995 Li L, Chin LS, Shupliakov O, Brodin L, Sihra TS, Hvalby O, Jensen V, Zheng D, McNamara JO, Greengard P. Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 92: 9235-9. PMID 7568108 DOI: 10.1073/pnas.92.20.9235  0.611
1995 Chin LS, Li L, Ferreira A, Kosik KS, Greengard P. Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice Proceedings of the National Academy of Sciences of the United States of America. 92: 9230-9234. PMID 7568107 DOI: 10.1073/Pnas.92.20.9230  0.361
1995 Ferreira A, Han HQ, Greengard P, Kosik KS. Suppression of synapsin II inhibits the formation and maintenance of synapses in hippocampal culture Proceedings of the National Academy of Sciences of the United States of America. 92: 9225-9229. PMID 7568106 DOI: 10.1073/Pnas.92.20.9225  0.34
1995 Nielander HB, Onofri F, Valtorta F, Schiavo G, Montecucco C, Greengard P, Benfenati F. Phosphorylation of VAMP/synaptobrevin in synaptic vesicles by endogenous protein kinases. Journal of Neurochemistry. 65: 1712-20. PMID 7561869 DOI: 10.1046/J.1471-4159.1995.65041712.X  0.708
1995 Xu H, Greengard P, Gandy S. Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein. The Journal of Biological Chemistry. 270: 23243-5. PMID 7559474 DOI: 10.1074/Jbc.270.40.23243  0.501
1995 Surmeier DJ, Bargas J, Hemmings HC, Nairn AC, Greengard P. Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons. Neuron. 14: 385-97. PMID 7531987 DOI: 10.1016/0896-6273(95)90294-5  0.753
1995 Li D, Aperia A, Celsi G, da Cruz e Silva EF, Greengard P, Meister B. Protein phosphatase-1 in the kidney: evidence for a role in the regulation of medullary Na(+)-K(+)-ATPase. The American Journal of Physiology. 269: F673-80. PMID 7503233 DOI: 10.1152/AJPRENAL.1995.269.5.F673  0.614
1995 da Cruz e Silva E, Fox C, Ouimet C, Gustafson E, Watson S, Greengard P. Differential expression of protein phosphatase 1 isoforms in mammalian brain The Journal of Neuroscience. 15: 3375-3389. DOI: 10.1523/Jneurosci.15-05-03375.1995  0.666
1995 Alder J, Kanki H, Valtorta F, Greengard P, Poo M. Overexpression of synaptophysin enhances neurotransmitter secretion at Xenopus neuromuscular synapses The Journal of Neuroscience. 15: 511-519. DOI: 10.1523/JNEUROSCI.15-01-00511.1995  0.516
1995 Nielander HB, Onofri F, Valtorta F, Schiavo G, Montecucco C, Greengard P, Benfenati F. Phosphorylation of VAMP/synaptobrevin in synaptic vesicles Pharmacological Research. 31: 212. DOI: 10.1016/1043-6618(95)87108-X  0.637
1995 da Cruz e Silva EF, da Cruz e Silva OAB, Zaia CTBV, Greengard P. Inhibition of Protein Phosphatase 1 Stimulates Secretion of Alzheimer Amyloid Precursor Protein Molecular Medicine. 1: 535-541. DOI: 10.1007/BF03401590  0.387
1994 Buxbaum JD, Ruefli AA, Parker CA, Cypess AM, Greengard P. Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Proceedings of the National Academy of Sciences of the United States of America. 91: 4489-93. PMID 8183935 DOI: 10.1073/PNAS.91.10.4489  0.599
1994 Ferreira A, Kosik KS, Greengard P, Han HQ. Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons Science. 264: 977-979. PMID 8178158 DOI: 10.1126/Science.8178158  0.359
1994 Schaeffer E, Alder J, Greengard P, Poo MM. Synapsin IIa accelerates functional development of neuromuscular synapses. Proceedings of the National Academy of Sciences of the United States of America. 91: 3882-6. PMID 8171006 DOI: 10.1073/PNAS.91.9.3882  0.465
1994 Näslund J, Schierhorn A, Hellman U, Lannfelt L, Roses AD, Tjernberg LO, Silberring J, Gandy SE, Winblad B, Greengard P. Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging. Proceedings of the National Academy of Sciences of the United States of America. 91: 8378-82. PMID 8078890 DOI: 10.1073/Pnas.91.18.8378  0.443
1994 McPherson PS, Czernik AJ, Chilcote TJ, Onofri F, Benfenati F, Greengard P, Schlessinger J, De Camilli P. Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I. Proceedings of the National Academy of Sciences of the United States of America. 91: 6486-90. PMID 8022809 DOI: 10.1073/Pnas.91.14.6486  0.603
1994 Dohadwala M, da Cruz e Silva EF, Hall FL, Williams RT, Carbonaro-Hall DA, Nairn AC, Greengard P, Berndt N. Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases. Proceedings of the National Academy of Sciences of the United States of America. 91: 6408-12. PMID 8022797 DOI: 10.1073/Pnas.91.14.6408  0.716
1994 Snyder GL, Fisone G, Greengard P. Phosphorylation of DARPP-32 is regulated by GABA in rat striatum and substantia nigra Journal of Neurochemistry. 63: 1766-1771. PMID 7931332 DOI: 10.1046/J.1471-4159.1994.63051766.X  0.367
1994 Chilcote TJ, Siow YL, Schaeffer E, Greengard P, Thiel G. Synapsin IIa bundles actin filaments. Journal of Neurochemistry. 63: 1568-71. PMID 7931311 DOI: 10.1046/j.1471-4159.1994.63041568.x  0.301
1994 Greengard P, Benfenati F, Valtorta F. Synapsin I, an actin-binding protein regulating synaptic vesicle traffic in the nerve terminal. Advances in Second Messenger and Phosphoprotein Research. 29: 31-45. PMID 7848718 DOI: 10.1016/S1040-7952(06)80005-4  0.626
1994 Gandy S, Caporaso G, Buxbaum J, Frangione B, Greengard P. APP processing, A beta-amyloidogenesis, and the pathogenesis of Alzheimer's disease. Neurobiology of Aging. 15: 253-6. PMID 7838304 DOI: 10.1016/0197-4580(94)90125-2  0.518
1994 Gandy S, Greengard P. Processing of Alzheimer A beta-amyloid precursor protein: cell biology, regulation, and role in Alzheimer disease International Review of Neurobiology. 36: 29-50. PMID 7822119 DOI: 10.1016/S0074-7742(08)60302-5  0.534
1994 Simonian NA, Elvhage T, Czernik AJ, Greengard P, Hyman BT. Calcium/calmodulin-dependent protein kinase II immunostaining is preserved in Alzheimer's disease hippocampal neurons Brain Research. 657: 294-299. PMID 7820630 DOI: 10.1016/0006-8993(94)90979-2  0.41
1994 Gandy S, Greengard P. Regulated cleavage of the Alzheimer amyloid precursor protein: Molecular and cellular basis Biochimie. 76: 300-303. PMID 7819339 DOI: 10.1016/0300-9084(94)90162-7  0.545
1994 Ouimet CC, Baerwald KD, Gandy SE, Greengard P. Immunocytochemical localization of amyloid precursor protein in rat brain. The Journal of Comparative Neurology. 348: 244-60. PMID 7814690 DOI: 10.1002/cne.903480207  0.74
1994 Miles K, Audigier S, Greengard P, Huganir R. Autoregulation of phosphorylation of the nicotinic acetylcholine receptor The Journal of Neuroscience. 14: 3271-3279. DOI: 10.1523/JNEUROSCI.14-05-03271.1994  0.416
1994 Caporaso G, Takei K, Gandy S, Matteoli M, Mundigl O, Greengard P, De Camilli P. Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein The Journal of Neuroscience. 14: 3122-3138. DOI: 10.1523/JNEUROSCI.14-05-03122.1994  0.662
1994 Suzuki T, Oishi M, Marshak D, Czernik A, Nairn A, Greengard P. Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. The Embo Journal. 13: 1114-1122. DOI: 10.1002/J.1460-2075.1994.Tb06360.X  0.664
1993 Iverfeldt K, Walaas SI, Greengard P. Altered processing of Alzheimer amyloid precursor protein in response to neuronal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 90: 4146-50. PMID 8483927 DOI: 10.1073/PNAS.90.9.4146  0.631
1993 Tsou K, Girault JA, Greengard P. Dopamine D1 agonist SKF 38393 increases the state of phosphorylation of ARPP-21 in substantia nigra. Journal of Neurochemistry. 60: 1043-6. PMID 8436957 DOI: 10.1111/j.1471-4159.1993.tb03252.x  0.566
1993 Greengard P, Valtorta F, Czernik AJ, Benfenati F. Synaptic vesicle phosphoproteins and regulation of synaptic function. Science (New York, N.Y.). 259: 780-5. PMID 8430330 DOI: 10.1126/Science.8430330  0.645
1993 Buxbaum JD, Koo EH, Greengard P. Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. Proceedings of the National Academy of Sciences of the United States of America. 90: 9195-8. PMID 8415676 DOI: 10.1073/Pnas.90.19.9195  0.553
1993 Barbas H, Gustafson EL, Greengard P. Comparison of the immunocytochemical localization of DARPP-32 and I-1 in the amygdala and hippocampus of the rhesus monkey. The Journal of Comparative Neurology. 334: 1-18. PMID 8408754 DOI: 10.1002/cne.903340102  0.358
1993 Tsou K, Snyder GL, Greengard P. Nitric oxide/cGMP pathway stimulates phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, in the substantia nigra. Proceedings of the National Academy of Sciences of the United States of America. 90: 3462-5. PMID 8386374 DOI: 10.1073/PNAS.90.8.3462  0.425
1993 Rubenstein JL, Greengard P, Czernik AJ. Calcium-dependent serine phosphorylation of synaptophysin. Synapse (New York, N.Y.). 13: 161-72. PMID 8383357 DOI: 10.1002/syn.890130207  0.385
1993 Li L, Suzuki T, Mori N, Greengard P. Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene. Proceedings of the National Academy of Sciences of the United States of America. 90: 1460-4. PMID 8381968 DOI: 10.1073/Pnas.90.4.1460  0.518
1993 Ceccaldi PE, Benfenati F, Chieregatti E, Greengard P, Valtorta F. Rapid binding of synapsin I to F- and G-actin. A study using fluorescence resonance energy transfer. Febs Letters. 329: 301-5. PMID 8365471 DOI: 10.1016/0014-5793(93)80242-M  0.645
1993 da Cruz e Silva OA, Iverfeldt K, Oltersdorf T, Sinha S, Lieberburg I, Ramabhadran TV, Suzuki T, Sisodia SS, Gandy S, Greengard P. Regulated cleavage of Alzheimer beta-amyloid precursor protein in the absence of the cytoplasmic tail. Neuroscience. 57: 873-7. PMID 8309547 DOI: 10.1016/0306-4522(93)90031-A  0.703
1993 Benfenati F, Valtorta F, Rossi MC, Onofri F, Sihra T, Greengard P. Interactions of synapsin I with phospholipids: possible role in synaptic vesicle clustering and in the maintenance of bilayer structures. The Journal of Cell Biology. 123: 1845-55. PMID 8276902 DOI: 10.1083/Jcb.123.6.1845  0.75
1993 Buxbaum JD, Christensen JL, Ruefli AA, Greengard P, Loring JF. Expression of APP in brains of transgenic mice containing the entire human APP gene. Biochemical and Biophysical Research Communications. 197: 639-45. PMID 8267600 DOI: 10.1006/bbrc.1993.2527  0.596
1993 Knops J, Gandy S, Greengard P, Lieberburg I, Sinha S. Serine phosphorylation of the secreted extracellular domain of APP. Biochemical and Biophysical Research Communications. 197: 380-5. PMID 8267571 DOI: 10.1006/bbrc.1993.2490  0.365
1993 Snyder GL, Fisone G, Morino P, Gundersen V, Ottersen OP, Hökfelt T, Greengard P. Regulation by the neuropeptide cholecystokinin (CCK-8S) of protein phosphorylation in the neostriatum. Proceedings of the National Academy of Sciences of the United States of America. 90: 11277-81. PMID 8248241 DOI: 10.1073/Pnas.90.23.11277  0.309
1993 Gandy SE, Caporaso GL, Buxbaum JD, de Cruz Silva O, Iverfeldt K, Nordstedt C, Suzuki T, Czernik AJ, Nairn AC, Greengard P. Protein phosphorylation regulates relative utilization of processing pathways for Alzheimer beta/A4 amyloid precursor protein. Annals of the New York Academy of Sciences. 695: 117-21. PMID 8239268 DOI: 10.1111/j.1749-6632.1993.tb23038.x  0.775
1993 Walaas SI, Greengard P. ARPP-39, a membrane-associated substrate for cyclic AMP-dependent protein kinase present in neostriatal neurons. Journal of Molecular Neuroscience : Mn. 4: 73-88. PMID 8217521 DOI: 10.1007/BF02782120  0.657
1993 Lu B, Fu WM, Greengard P, Poo MM. Calcitonin gene-related peptide potentiates synaptic responses at developing neuromuscular junction. Nature. 363: 76-9. PMID 7683114 DOI: 10.1038/363076a0  0.693
1993 Benfenati F, Valtorta F, Neyroz P, Greengard P. Binding of synapsin i to synaptic vesicles: Clues from the study of its interactions with liposomes Journal of Liposome Research. 3: 599-609. DOI: 10.3109/08982109309150742  0.655
1992 Benfenati F, Valtorta F, Chieregatti E, Greengard P. Interaction of free and synaptic vesicle-bound synapsin I with F-actin. Neuron. 8: 377-86. PMID 1739463 DOI: 10.1016/0896-6273(92)90303-U  0.669
1992 Suzuki T, Nairn AC, Gandy SE, Greengard P. Phosphorylation of Alzheimer amyloid precursor protein by protein kinase C. Neuroscience. 48: 755-61. PMID 1630623 DOI: 10.1016/0306-4522(92)90264-3  0.72
1992 Gandy S, Greengard P. Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities Trends in Pharmacological Sciences. 13: 108-113. PMID 1574806 DOI: 10.1016/0165-6147(92)90039-9  0.541
1992 Siow YL, Chilcote TJ, Benfenati F, Greengard P, Thiel G. Synapsin IIa: expression in insect cells, purification, and characterization. Biochemistry. 31: 4268-75. PMID 1567872 DOI: 10.1021/Bi00132A017  0.519
1992 Caporaso GL, Gandy SE, Buxbaum JD, Ramabhadran TV, Greengard P. Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 89: 3055-9. PMID 1557413 DOI: 10.1073/PNAS.89.7.3055  0.682
1992 Caporaso GL, Gandy SE, Buxbaum JD, Greengard P. Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 89: 2252-6. PMID 1549591 DOI: 10.1073/PNAS.89.6.2252  0.681
1992 Torri Tarelli F, Bossi M, Fesce R, Greengard P, Valtorta F. Synapsin I partially dissociates from synaptic vesicles during exocytosis induced by electrical stimulation. Neuron. 9: 1143-53. PMID 1463610 DOI: 10.1016/0896-6273(92)90072-L  0.58
1992 Gandy SE, Buxbaum JD, Suzuki T, Ramabhadran TV, Caporaso GL, Nairn AC, Greengard P. The nature and metabolism of potentially amyloidogenic carboxyl-terminal fragments of the Alzheimer beta/A4-amyloid precursor protein: some technical notes. Neurobiology of Aging. 13: 601-3. PMID 1461349 DOI: 10.1016/0197-4580(92)90063-4  0.791
1992 Girault JA, Chamak B, Bertuzzi G, Tixier H, Wang JK, Pang DT, Greengard P. Protein phosphotyrosine in mouse brain: developmental changes and regulation by epidermal growth factor, type I insulin-like growth factor, and insulin. Journal of Neurochemistry. 58: 518-28. PMID 1370320 DOI: 10.1111/j.1471-4159.1992.tb09751.x  0.547
1992 Gandy SE, Caporaso GL, Ramabhadran TV, Suzuki T, Buxbaum JD, Nordstedt C, Iverfeldt K, Czernik AJ, Nairn AC, Greengard P. Characterization of alternative routes for processing of the Alzheimer beta/A4-amyloid precursor protein. Differential effects of phorbol esters and chloroquine. Annals of the New York Academy of Sciences. 674: 203-17. PMID 1363189 DOI: 10.1111/J.1749-6632.1992.Tb27489.X  0.763
1992 Buxbaum JD, Oishi M, Chen HI, Pinkas-Kramarski R, Jaffe EA, Gandy SE, Greengard P. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proceedings of the National Academy of Sciences of the United States of America. 89: 10075-8. PMID 1359534 DOI: 10.1073/PNAS.89.21.10075  0.69
1992 Alder J, Xie ZP, Valtorta F, Greengard P, Poo M. Antibodies to synaptophysin interfere with transmitter secretion at neuromuscular synapses. Neuron. 9: 759-68. PMID 1356373 DOI: 10.1016/0896-6273(92)90038-F  0.673
1992 Alder J, Lu B, Valtorta F, Greengard P, Poo MM. Calcium-dependent transmitter secretion reconstituted in Xenopus oocytes: requirement for synaptophysin. Science (New York, N.Y.). 257: 657-61. PMID 1353905 DOI: 10.1126/Science.1353905  0.721
1992 Hemmings HC, Girault JA, Nairn AC, Bertuzzi G, Greengard P. Distribution of protein phosphatase inhibitor-1 in brain and peripheral tissues of various species: comparison with DARPP-32. Journal of Neurochemistry. 59: 1053-61. PMID 1353788 DOI: 10.1111/j.1471-4159.1992.tb08347.x  0.692
1992 Nichols RA, Chilcote TJ, Czernik AJ, Greengard P. Synapsin I regulates glutamate release from rat brain synaptosomes. Journal of Neurochemistry. 58: 783-5. PMID 1345942 DOI: 10.1111/J.1471-4159.1992.Tb09788.X  0.599
1992 Gandy SE, Bhasin R, Ramabhadran TV, Koo EH, Price DL, Goldgaber D, Greengard P. Alzheimer beta/A4-amyloid precursor protein: evidence for putative amyloidogenic fragment. Journal of Neurochemistry. 58: 383-6. PMID 1345769 DOI: 10.1111/J.1471-4159.1992.Tb09322.X  0.531
1992 Benfenati F, Valtorta F, Rubenstein JL, Gorelick FS, Greengard P, Czernik AJ. Synaptic vesicle-associated Ca2+/calmodulin-dependent protein kinase II is a binding protein for synapsin I. Nature. 359: 417-20. PMID 1328883 DOI: 10.1038/359417A0  0.697
1992 Ouimet CC, LaMantia AS, Goldman-Rakic P, Rakic P, Greengard P. Immunocytochemical localization of DARPP-32, a dopamine and cyclic-AMP-regulated phosphoprotein, in the primate brain. The Journal of Comparative Neurology. 323: 209-18. PMID 1328330 DOI: 10.1002/Cne.903230206  0.672
1992 Lu B, Greengard P, Poo MM. Exogenous synapsin I promotes functional maturation of developing neuromuscular synapses. Neuron. 8: 521-9. PMID 1312849 DOI: 10.1016/0896-6273(92)90280-Q  0.686
1992 Snyder G, Girault J, Chen J, Czernik A, Kebabian J, Nathanson J, Greengard P. Phosphorylation of DARPP-32 and protein phosphatase inhibitor-1 in rat choroid plexus: regulation by factors other than dopamine The Journal of Neuroscience. 12: 3071-3083. DOI: 10.1523/JNEUROSCI.12-08-03071.1992  0.412
1992 Mandell J, Czernik A, De Camilli P, Greengard P, Townes-Anderson E. Differential expression of synapsins I and II among rat retinal synapses The Journal of Neuroscience. 12: 1736-1749. DOI: 10.1523/JNEUROSCI.12-05-01736.1992  0.384
1991 Bähler M, Klein RL, Wang JK, Benfenati F, Greengard P. A novel synaptic vesicle-associated phosphoprotein: SVAPP-120. Journal of Neurochemistry. 57: 423-30. PMID 2072093 DOI: 10.1111/J.1471-4159.1991.Tb03769.X  0.537
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