Leonid Kruglyak, Ph.D. - Publications

Affiliations: 
Genomics and Evolutionary Biology Princeton University, Princeton, NJ 
Website:
http://www.princeton.edu/genomics/kruglyak/

151 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Gou L, Bloom JS, Kruglyak L. The Genetic Basis of Mutation Rate Variation in Yeast. Genetics. PMID 30504363 DOI: 10.1534/genetics.118.301609  0.6
2018 Albert FW, Bloom JS, Siegel J, Day L, Kruglyak L. Genetics of -regulatory variation in gene expression. Elife. 7. PMID 30014850 DOI: 10.7554/eLife.35471  0.6
2018 Sadhu MJ, Bloom JS, Day L, Siegel JJ, Kosuri S, Kruglyak L. Highly parallel genome variant engineering with CRISPR-Cas9. Nature Genetics. 50: 510-514. PMID 29632376 DOI: 10.1038/s41588-018-0087-y  0.6
2017 Jerison ER, Kryazhimskiy S, Mitchell JK, Bloom JS, Kruglyak L, Desai MM. Genetic variation in adaptability and pleiotropy in budding yeast. Elife. 6. PMID 28826486 DOI: 10.7554/eLife.27167  0.6
2017 Lee D, Yang H, Kim J, Brady S, Zdraljevic S, Zamanian M, Kim H, Paik YK, Kruglyak L, Andersen EC, Lee J. The genetic basis of natural variation in a phoretic behavior. Nature Communications. 8: 273. PMID 28819099 DOI: 10.1038/s41467-017-00386-x  0.48
2017 Forsberg SK, Bloom JS, Sadhu MJ, Kruglyak L, Carlborg Ö. Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast. Nature Genetics. PMID 28250458 DOI: 10.1038/ng.3800  0.6
2016 Cook DC, Zdraljevic S, Tanny RE, Seo B, Riccardi DD, Noble LM, Rockman MV, Alkema MJ, Braendle C, Kammenga JE, Wang J, Kruglyak L, Félix MA, Lee J, Andersen EC. The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length. Genetics. PMID 27449056 DOI: 10.1534/genetics.116.191148  0.48
2016 Sadhu MJ, Bloom JS, Day L, Kruglyak L. CRISPR-directed mitotic recombination enables genetic mapping without crosses. Science (New York, N.Y.). 352: 1113-6. PMID 27230379 DOI: 10.1126/science.aaf5124  0.6
2015 Bloom JS, Kotenko I, Sadhu MJ, Treusch S, Albert FW, Kruglyak L. Genetic interactions contribute less than additive effects to quantitative trait variation in yeast. Nature Communications. 6: 8712. PMID 26537231 DOI: 10.1038/ncomms9712  0.6
2015 Ghosh R, Bloom JS, Mohammadi A, Schumer ME, Andolfatto P, Ryu W, Kruglyak L. Genetics of Intra-Species Variation in Avoidance Behavior Induced by a Thermal Stimulus in Caenorhabditis elegans. Genetics. PMID 26092720 DOI: 10.1534/genetics.115.178491  0.6
2015 Thompson OA, Snoek LB, Nijveen H, Sterken MG, Volkers RJ, Brenchley R, Van't Hof A, Bevers RP, Cossins AR, Yanai I, Hajnal A, Schmid T, Perkins JD, Spencer D, Kruglyak L, et al. Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis elegans Hawaiian Strain CB4856. Genetics. 200: 975-89. PMID 25995208 DOI: 10.1534/genetics.115.175950  0.6
2015 Thomas CG, Wang W, Jovelin R, Ghosh R, Lomasko T, Trinh Q, Kruglyak L, Stein LD, Cutter AD. Full-genome evolutionary histories of selfing, splitting, and selection in Caenorhabditis. Genome Research. 25: 667-78. PMID 25783854 DOI: 10.1101/gr.187237.114  0.48
2015 Andersen EC, Shimko TC, Crissman JR, Ghosh R, Bloom JS, Seidel HS, Gerke JP, Kruglyak L. A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains. G3 (Bethesda, Md.). 5: 911-20. PMID 25770127 DOI: 10.1534/g3.115.017178  0.6
2015 Albert FW, Kruglyak L. The role of regulatory variation in complex traits and disease. Nature Reviews. Genetics. 16: 197-212. PMID 25707927 DOI: 10.1038/nrg3891  0.6
2015 Balla KM, Andersen EC, Kruglyak L, Troemel ER. A wild C. elegans strain has enhanced epithelial immunity to a natural microsporidian parasite. Plos Pathogens. 11: e1004583. PMID 25680197 DOI: 10.1371/journal.ppat.1004583  0.6
2015 Treusch S, Albert FW, Bloom JS, Kotenko IE, Kruglyak L. Genetic mapping of MAPK-mediated complex traits Across S. cerevisiae. Plos Genetics. 11: e1004913. PMID 25569670 DOI: 10.1371/journal.pgen.1004913  0.6
2014 Wang X, Kruglyak L. Genetic basis of haloperidol resistance in Saccharomyces cerevisiae is complex and dose dependent. Plos Genetics. 10: e1004894. PMID 25521586 DOI: 10.1371/journal.pgen.1004894  0.6
2014 Albert FW, Muzzey D, Weissman JS, Kruglyak L. Genetic influences on translation in yeast. Plos Genetics. 10: e1004692. PMID 25340754 DOI: 10.1371/journal.pgen.1004692  0.6
2014 Heyne HO, Lautenschläger S, Nelson R, Besnier F, Rotival M, Cagan A, Kozhemyakina R, Plyusnina IZ, Trut L, Carlborg Ö, Petretto E, Kruglyak L, Pääbo S, Schöneberg T, Albert FW. Genetic influences on brain gene expression in rats selected for tameness and aggression. Genetics. 198: 1277-90. PMID 25189874 DOI: 10.1534/genetics.114.168948  0.6
2014 Breunig JS, Hackett SR, Rabinowitz JD, Kruglyak L. Genetic basis of metabolome variation in yeast. Plos Genetics. 10: e1004142. PMID 24603560 DOI: 10.1371/journal.pgen.1004142  0.6
2014 Andersen EC, Bloom JS, Gerke JP, Kruglyak L. A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology. Plos Genetics. 10: e1004156. PMID 24586193 DOI: 10.1371/journal.pgen.1004156  0.6
2014 Albert FW, Treusch S, Shockley AH, Bloom JS, Kruglyak L. Genetics of single-cell protein abundance variation in large yeast populations. Nature. 506: 494-7. PMID 24402228 DOI: 10.1038/nature12904  0.6
2013 Reisser C, Dick C, Kruglyak L, Botstein D, Schacherer J, Hess D. Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case. G3 (Bethesda, Md.). PMID 23550140 DOI: 10.1534/g3.113.005884  0.6
2013 Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A. A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. Plos Genetics. 9: e1003329. PMID 23505383 DOI: 10.1371/journal.pgen.1003329  0.6
2013 Bloom JS, Ehrenreich IM, Loo WT, Lite TL, Kruglyak L. Finding the sources of missing heritability in a yeast cross. Nature. 494: 234-7. PMID 23376951 DOI: 10.1038/nature11867  0.6
2012 Bendesky A, Pitts J, Rockman MV, Chen WC, Tan MW, Kruglyak L, Bargmann CI. Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans. Plos Genetics. 8: e1003157. PMID 23284308 DOI: 10.1371/journal.pgen.1003157  0.6
2012 Ghosh R, Mohammadi A, Kruglyak L, Ryu WS. Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans. Bmc Biology. 10: 85. PMID 23114012 DOI: 10.1186/1741-7007-10-85  0.6
2012 Gaertner BE, Parmenter MD, Rockman MV, Kruglyak L, Phillips PC. More than the sum of its parts: a complex epistatic network underlies natural variation in thermal preference behavior in Caenorhabditis elegans. Genetics. 192: 1533-42. PMID 23086219 DOI: 10.1534/genetics.112.142877  0.6
2012 Khan Z, Bloom JS, Amini S, Singh M, Perlman DH, Caudy AA, Kruglyak L. Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS. Molecular Systems Biology. 8: 602. PMID 22893000 DOI: 10.1038/msb.2012.34  0.6
2012 Reaves ML, Sinha S, Rabinowitz JD, Kruglyak L, Redfield RJ. Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells. Science (New York, N.Y.). 337: 470-3. PMID 22773140 DOI: 10.1126/science.1219861  0.6
2012 Ehrenreich IM, Bloom J, Torabi N, Wang X, Jia Y, Kruglyak L. Genetic architecture of highly complex chemical resistance traits across four yeast strains. Plos Genetics. 8: e1002570. PMID 22438822 DOI: 10.1371/journal.pgen.1002570  0.6
2012 Torabi N, Kruglyak L. Genetic basis of hidden phenotypic variation revealed by increased translational readthrough in yeast. Plos Genetics. 8: e1002546. PMID 22396662 DOI: 10.1371/journal.pgen.1002546  0.6
2012 Ghosh R, Andersen EC, Shapiro JA, Gerke JP, Kruglyak L. Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans. Science (New York, N.Y.). 335: 574-8. PMID 22301316 DOI: 10.1126/science.1214318  0.6
2012 Andersen EC, Gerke JP, Shapiro JA, Crissman JR, Ghosh R, Bloom JS, Félix MA, Kruglyak L. Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity. Nature Genetics. 44: 285-90. PMID 22286215 DOI: 10.1038/ng.1050  0.6
2011 Khan Z, Amini S, Bloom JS, Ruse C, Caudy AA, Kruglyak L, Singh M, Perlman DH, Tavazoie S. Accurate proteome-wide protein quantification from high-resolution 15N mass spectra. Genome Biology. 12: R122. PMID 22182234 DOI: 10.1186/gb-2011-12-12-r122  0.6
2011 Foss EJ, Radulovic D, Shaffer SA, Goodlett DR, Kruglyak L, Bedalov A. Genetic variation shapes protein networks mainly through non-transcriptional mechanisms. Plos Biology. 9: e1001144. PMID 21909241 DOI: 10.1371/journal.pbio.1001144  0.6
2011 Kwan EX, Foss E, Kruglyak L, Bedalov A. Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. Plos Genetics. 7: e1002250. PMID 21901113 DOI: 10.1371/journal.pgen.1002250  0.6
2011 Torabi N, Kruglyak L. Variants in SUP45 and TRM10 underlie natural variation in translation termination efficiency in Saccharomyces cerevisiae. Plos Genetics. 7: e1002211. PMID 21829385 DOI: 10.1371/journal.pgen.1002211  0.6
2011 Seidel HS, Ailion M, Li J, van Oudenaarden A, Rockman MV, Kruglyak L. A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans. Plos Biology. 9: e1001115. PMID 21814493 DOI: 10.1371/journal.pbio.1001115  0.6
2011 Bendesky A, Tsunozaki M, Rockman MV, Kruglyak L, Bargmann CI. Catecholamine receptor polymorphisms affect decision-making in C. elegans. Nature. 472: 313-8. PMID 21412235 DOI: 10.1038/nature09821  0.6
2010 Rockman MV, Skrovanek SS, Kruglyak L. Selection at linked sites shapes heritable phenotypic variation in C. elegans. Science (New York, N.Y.). 330: 372-6. PMID 20947766 DOI: 10.1126/science.1194208  0.6
2010 Ehrenreich IM, Torabi N, Jia Y, Kent J, Martis S, Shapiro JA, Gresham D, Caudy AA, Kruglyak L. Dissection of genetically complex traits with extremely large pools of yeast segregants. Nature. 464: 1039-42. PMID 20393561 DOI: 10.1038/nature08923  0.6
2010 Gresham D, Curry B, Ward A, Gordon DB, Brizuela L, Kruglyak L, Botstein D. Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes. Proceedings of the National Academy of Sciences of the United States of America. 107: 1482-7. PMID 20080586 DOI: 10.1073/pnas.0913883107  0.6
2009 Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, et al. Finding the missing heritability of complex diseases. Nature. 461: 747-53. PMID 19812666 DOI: 10.1038/nature08494  0.6
2009 Ehrenreich IM, Gerke JP, Kruglyak L. Genetic dissection of complex traits in yeast: insights from studies of gene expression and other phenotypes in the BYxRM cross. Cold Spring Harbor Symposia On Quantitative Biology. 74: 145-53. PMID 19734204 DOI: 10.1101/sqb.2009.74.013  0.6
2009 Ruderfer DM, Roberts DC, Schreiber SL, Perlstein EO, Kruglyak L. Using expression and genotype to predict drug response in yeast. Plos One. 4: e6907. PMID 19730698 DOI: 10.1371/journal.pone.0006907  0.6
2009 Khan Z, Bloom JS, Garcia BA, Singh M, Kruglyak L. Protein quantification across hundreds of experimental conditions. Proceedings of the National Academy of Sciences of the United States of America. 106: 15544-8. PMID 19717460 DOI: 10.1073/pnas.0904100106  0.6
2009 Dimitrov LN, Brem RB, Kruglyak L, Gottschling DE. Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains. Genetics. 183: 365-83. PMID 19581448 DOI: 10.1534/genetics.109.104497  0.6
2009 Kruglyak L, Storey JD. Cause and express. Nature Biotechnology. 27: 544-5. PMID 19513058 DOI: 10.1038/nbt0609-544  0.6
2009 Bloom JS, Khan Z, Kruglyak L, Singh M, Caudy AA. Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays. Bmc Genomics. 10: 221. PMID 19435513 DOI: 10.1186/1471-2164-10-221  0.6
2009 Khan Z, Bloom JS, Kruglyak L, Singh M. A practical algorithm for finding maximal exact matches in large sequence datasets using sparse suffix arrays. Bioinformatics (Oxford, England). 25: 1609-16. PMID 19389736 DOI: 10.1093/bioinformatics/btp275  0.6
2009 McGrath PT, Rockman MV, Zimmer M, Jang H, Macosko EZ, Kruglyak L, Bargmann CI. Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory behaviors. Neuron. 61: 692-9. PMID 19285466 DOI: 10.1016/j.neuron.2009.02.012  0.6
2009 Rockman MV, Kruglyak L. Recombinational landscape and population genomics of Caenorhabditis elegans. Plos Genetics. 5: e1000419. PMID 19283065 DOI: 10.1371/journal.pgen.1000419  0.6
2009 Schacherer J, Shapiro JA, Ruderfer DM, Kruglyak L. Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae. Nature. 458: 342-5. PMID 19212320 DOI: 10.1038/nature07670  0.6
2009 Reddy KC, Andersen EC, Kruglyak L, Kim DH. A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans. Science (New York, N.Y.). 323: 382-4. PMID 19150845 DOI: 10.1126/science.1166527  0.48
2008 Capra EJ, Skrovanek SM, Kruglyak L. Comparative developmental expression profiling of two C. elegans isolates. Plos One. 3: e4055. PMID 19116648 DOI: 10.1371/journal.pone.0004055  0.48
2008 Coller HA, Kruglyak L. Genetics. It's the sequence, stupid! Science (New York, N.Y.). 322: 380-1. PMID 18927376 DOI: 10.1126/science.1165664  0.48
2008 Gresham D, Kruglyak L. Rise of the machines. Plos Genetics. 4: e1000134. PMID 18670625 DOI: 10.1371/journal.pgen.1000134  0.48
2008 Palopoli MF, Rockman MV, TinMaung A, Ramsay C, Curwen S, Aduna A, Laurita J, Kruglyak L. Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans. Nature. 454: 1019-22. PMID 18633349 DOI: 10.1038/nature07171  0.48
2008 Demogines A, Smith E, Kruglyak L, Alani E. Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast. Plos Genetics. 4: e1000123. PMID 18617998 DOI: 10.1371/journal.pgen.1000123  0.48
2008 Zhu J, Zhang B, Smith EN, Drees B, Brem RB, Kruglyak L, Bumgarner RE, Schadt EE. Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nature Genetics. 40: 854-61. PMID 18552845 DOI: 10.1038/ng.167  0.48
2008 Rockman MV, Kruglyak L. Breeding designs for recombinant inbred advanced intercross lines. Genetics. 179: 1069-78. PMID 18505881 DOI: 10.1534/genetics.107.083873  0.48
2008 Smith EN, Kruglyak L. Gene-environment interaction in yeast gene expression. Plos Biology. 6: e83. PMID 18416601 DOI: 10.1371/journal.pbio.0060083  0.48
2008 Kruglyak L. The road to genome-wide association studies. Nature Reviews. Genetics. 9: 314-8. PMID 18283274 DOI: 10.1038/nrg2316  0.48
2008 Seidel HS, Rockman MV, Kruglyak L. Widespread genetic incompatibility in C. elegans maintained by balancing selection. Science (New York, N.Y.). 319: 589-94. PMID 18187622 DOI: 10.1126/science.1151107  0.48
2007 Foss EJ, Radulovic D, Shaffer SA, Ruderfer DM, Bedalov A, Goodlett DR, Kruglyak L. Genetic basis of proteome variation in yeast. Nature Genetics. 39: 1369-75. PMID 17952072 DOI: 10.1038/ng.2007.22  0.48
2007 Kruglyak L, Stern DL. Evolution. An embarrassment of switches. Science (New York, N.Y.). 317: 758-9. PMID 17690280 DOI: 10.1126/science.1146921  0.48
2007 Schacherer J, Ruderfer DM, Gresham D, Dolinski K, Botstein D, Kruglyak L. Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains. Plos One. 2: e322. PMID 17389913 DOI: 10.1371/journal.pone.0000322  0.48
2007 Perlstein EO, Ruderfer DM, Roberts DC, Schreiber SL, Kruglyak L. Genetic basis of individual differences in the response to small-molecule drugs in yeast. Nature Genetics. 39: 496-502. PMID 17334364 DOI: 10.1038/ng1991  0.48
2006 Rockman MV, Kruglyak L. Genetics of global gene expression. Nature Reviews. Genetics. 7: 862-72. PMID 17047685 DOI: 10.1038/nrg1964  0.48
2006 Eberle MA, Rieder MJ, Kruglyak L, Nickerson DA. Allele frequency matching between SNPs reveals an excess of linkage disequilibrium in genic regions of the human genome. Plos Genetics. 2: e142. PMID 16965180 DOI: 10.1371/journal.pgen.0020142  0.48
2006 Ruderfer DM, Pratt SC, Seidel HS, Kruglyak L. Population genomic analysis of outcrossing and recombination in yeast. Nature Genetics. 38: 1077-81. PMID 16892060 DOI: 10.1038/ng1859  0.48
2006 Riehle MM, Markianos K, Niaré O, Xu J, Li J, Touré AM, Podiougou B, Oduol F, Diawara S, Diallo M, Coulibaly B, Ouatara A, Kruglyak L, Traoré SF, Vernick KD. Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. Science (New York, N.Y.). 312: 577-9. PMID 16645095 DOI: 10.1126/science.1124153  0.48
2006 Perlstein EO, Ruderfer DM, Ramachandran G, Haggarty SJ, Kruglyak L, Schreiber SL. Revealing complex traits with small molecules and naturally recombinant yeast strains. Chemistry & Biology. 13: 319-27. PMID 16638537 DOI: 10.1016/j.chembiol.2006.01.010  0.48
2006 Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A. Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. Plos Genetics. 2: e35. PMID 16552446 DOI: 10.1371/journal.pgen.0020035  0.48
2006 Gresham D, Ruderfer DM, Pratt SC, Schacherer J, Dunham MJ, Botstein D, Kruglyak L. Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray. Science (New York, N.Y.). 311: 1932-6. PMID 16527929 DOI: 10.1126/science.1123726  0.48
2006 Parker HG, Kruglyak L, Ostrander EA. Molecular genetics: DNA analysis of a putative dog clone. Nature. 440: E1-2. PMID 16525421 DOI: 10.1038/nature04685  0.48
2005 Kruglyak L. Power tools for human genetics. Nature Genetics. 37: 1299-300. PMID 16314858 DOI: 10.1038/ng1205-1299  0.48
2005 Ronald J, Brem RB, Whittle J, Kruglyak L. Local regulatory variation in Saccharomyces cerevisiae. Plos Genetics. 1: e25. PMID 16121257 DOI: 10.1371/journal.pgen.0010025  0.48
2005 Brem RB, Storey JD, Whittle J, Kruglyak L. Genetic interactions between polymorphisms that affect gene expression in yeast. Nature. 436: 701-3. PMID 16079846 DOI: 10.1038/nature03865  0.48
2005 Storey JD, Akey JM, Kruglyak L. Multiple locus linkage analysis of genomewide expression in yeast. Plos Biology. 3: e267. PMID 16035920 DOI: 10.1371/journal.pbio.0030267  0.48
2005 Ronald J, Akey JM, Whittle J, Smith EN, Yvert G, Kruglyak L. Simultaneous genotyping, gene-expression measurement, and detection of allele-specific expression with oligonucleotide arrays. Genome Research. 15: 284-91. PMID 15687292 DOI: 10.1101/gr.2850605  0.48
2005 Brem RB, Kruglyak L. The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proceedings of the National Academy of Sciences of the United States of America. 102: 1572-7. PMID 15659551 DOI: 10.1073/pnas.0408709102  0.48
2005 Carlson CS, Reider MJ, Nickerson DA, Eberle MA, Kruglyak L. Comment on 'Discrepancies in dbSNP confirmations rates and allele frequency distributions from varying genotyping error rates and patterns'. Bioinformatics (Oxford, England). 21: 141-3. PMID 15333455 DOI: 10.1093/bioinformatics/bth492  0.48
2004 Sutter NB, Eberle MA, Parker HG, Pullar BJ, Kirkness EF, Kruglyak L, Ostrander EA. Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome Research. 14: 2388-96. PMID 15545498 DOI: 10.1101/gr.3147604  0.48
2004 Akey JM, Eberle MA, Rieder MJ, Carlson CS, Shriver MD, Nickerson DA, Kruglyak L. Population history and natural selection shape patterns of genetic variation in 132 genes. Plos Biology. 2: e286. PMID 15361935 DOI: 10.1371/journal.pbio.0020286  0.48
2004 Abecasis G, Cox N, Daly MJ, Kruglyak L, Laird N, Markianos K, Patterson N. No bias in linkage analysis. American Journal of Human Genetics. 75: 722-3; author reply . PMID 15338460 DOI: 10.1086/424757  0.48
2004 Mukhopadhyay I, Feingold E, Weeks DE, Visscher PM, Wray NR, Sieberts SK, Broman KW, Gudbjartsson DF, Abecasis G, Cox N, Daly MJ, Kruglyak L, Laird N, Markianos K, Patterson N, et al. No "bias" toward the null hypothesis in most conventional multipoint nonparametric linkage analyses [1] (multiple letters) American Journal of Human Genetics. 75: 716-727. PMID 15338457 DOI: 10.1086/424754  0.48
2004 Furman I, Rieder MJ, Da Ponte S, Carrington DP, Nickerson DA, Kruglyak L, Markianos K. Sequence-based linkage analysis. American Journal of Human Genetics. 75: 647-53. PMID 15329798 DOI: 10.1086/424888  0.48
2004 Carlson CS, Eberle MA, Kruglyak L, Nickerson DA. Mapping complex disease loci in whole-genome association studies. Nature. 429: 446-52. PMID 15164069 DOI: 10.1038/nature02623  0.48
2004 Parker HG, Kim LV, Sutter NB, Carlson S, Lorentzen TD, Malek TB, Johnson GS, DeFrance HB, Ostrander EA, Kruglyak L. Genetic structure of the purebred domestic dog. Science (New York, N.Y.). 304: 1160-4. PMID 15155949 DOI: 10.1126/science.1097406  0.48
2004 Crawford DC, Carlson CS, Rieder MJ, Carrington DP, Yi Q, Smith JD, Eberle MA, Kruglyak L, Nickerson DA. Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. American Journal of Human Genetics. 74: 610-22. PMID 15015130 DOI: 10.1086/382227  0.48
2004 Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. American Journal of Human Genetics. 74: 106-20. PMID 14681826 DOI: 10.1086/381000  0.48
2003 Yvert G, Brem RB, Whittle J, Akey JM, Foss E, Smith EN, Mackelprang R, Kruglyak L. Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nature Genetics. 35: 57-64. PMID 12897782 DOI: 10.1038/ng1222  0.48
2003 Matise TC, Sachidanandam R, Clark AG, Kruglyak L, Wijsman E, Kakol J, Buyske S, Chui B, Cohen P, de Toma C, Ehm M, Glanowski S, He C, Heil J, Markianos K, et al. A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. American Journal of Human Genetics. 73: 271-84. PMID 12844283 DOI: 10.1086/377137  0.48
2003 Carlson CS, Eberle MA, Rieder MJ, Smith JD, Kruglyak L, Nickerson DA. Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans. Nature Genetics. 33: 518-21. PMID 12652300 DOI: 10.1038/ng1128  0.48
2002 Niaré O, Markianos K, Volz J, Oduol F, Touré A, Bagayoko M, Sangaré D, Traoré SF, Wang R, Blass C, Dolo G, Bouaré M, Kafatos FC, Kruglyak L, Touré YT, et al. Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population. Science (New York, N.Y.). 298: 213-6. PMID 12364806 DOI: 10.1126/science.1073420  0.48
2002 Ardlie KG, Kruglyak L, Seielstad M. Patterns of linkage disequilibrium in the human genome. Nature Reviews. Genetics. 3: 299-309. PMID 11967554 DOI: 10.1038/nrg777  0.48
2002 Brem RB, Yvert G, Clinton R, Kruglyak L. Genetic dissection of transcriptional regulation in budding yeast. Science (New York, N.Y.). 296: 752-5. PMID 11923494 DOI: 10.1126/science.1069516  0.48
2002 Lindgren CM, Mahtani MM, Widén E, McCarthy MI, Daly MJ, Kirby A, Reeve MP, Kruglyak L, Parker A, Meyer J, Almgren P, Lehto M, Kanninen T, Tuomi T, Groop LC, et al. Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study. American Journal of Human Genetics. 70: 509-16. PMID 11791216 DOI: 10.1086/338629  0.48
2001 Markianos K, Carlson S, Gibbs M, Kruglyak L. A joint analysis of asthma affection status and IgE levels in multiple data sets collected for asthma. Genetic Epidemiology. 21: S148-53. PMID 11793658  0.48
2001 Ardlie K, Liu-Cordero SN, Eberle MA, Daly M, Barrett J, Winchester E, Lander ES, Kruglyak L. Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion. American Journal of Human Genetics. 69: 582-9. PMID 11473344 DOI: 10.1086/323251  0.48
2001 Subrahmanyan L, Eberle MA, Clark AG, Kruglyak L, Nickerson DA. Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus. American Journal of Human Genetics. 69: 381-95. PMID 11438886 DOI: 10.1086/321297  0.48
2001 Markianos K, Daly MJ, Kruglyak L. Efficient multipoint linkage analysis through reduction of inheritance space. American Journal of Human Genetics. 68: 963-77. PMID 11254453 DOI: 10.1086/319507  0.48
2001 Kruglyak L, Nickerson DA. Variation is the spice of life. Nature Genetics. 27: 234-6. PMID 11242096 DOI: 10.1038/85776  0.48
2000 Bailey-Wilson J, Baron J, Cawthon R, Christian JC, Corder EH, Franceschi C, Kestenbaum B, Kruglyak L, Lauderdale DS, Lubitz J, Martin GM, McClearn GE, McGue M, Miles T, Mineau G, et al. Genetic epidemiologic studies on age-specified traits American Journal of Epidemiology. 152: 1003-1008. PMID 11117608 DOI: 10.1093/aje/152.11.1003  0.48
2000 Sham PC, Zhao JH, Cherny SS, Hewitt JK. Variance-Components QTL linkage analysis of selected and non-normal samples: conditioning on trait values. Genetic Epidemiology. 19: S22-8. PMID 11055366 DOI: 10.1002/1098-2272(2000)19:1+<::AID-GEPI4>3.0.CO;2-S  0.48
2000 Altshuler D, Daly M, Kruglyak L. Guilt by association. Nature Genetics. 26: 135-7. PMID 11017062 DOI: 10.1038/79839  0.48
2000 Ostrander EA, Kruglyak L. Unleashing the canine genome. Genome Research. 10: 1271-4. PMID 10984444 DOI: 10.1101/gr.155900  0.48
2000 Yang Z, Wong GK, Eberle MA, Kibukawa M, Passey DA, Hughes WR, Kruglyak L, Yu J. Sampling SNPs. Nature Genetics. 26: 13-4. PMID 10973237 DOI: 10.1038/79113  0.48
2000 Nancarrow DJ, Levinson DF, Taylor JM, Hayward NK, Walters MK, Lennon DP, Nertney DA, Jones HL, Mahtani MM, Kirby A, Kruglyak L, Brown DM, Crowe RR, Andreasen NC, Black DW, et al. No support for linkage to the bipolar regions on chromosomes 4p, 18p, or 18q in 43 schizophrenia pedigrees. American Journal of Medical Genetics. 96: 224-7. PMID 10893501 DOI: 10.1002/(SICI)1096-8628(20000403)96:2<224::AID-AJMG19>3.0.CO;2-2  0.48
2000 Rasko JE, Battini JL, Kruglyak L, Cox DR, Miller AD. Precise gene localization by phenotypic assay of radiation hybrid cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 7388-92. PMID 10852967 DOI: 10.1073/pnas.130200097  0.48
2000 Pratt SC, Daly MJ, Kruglyak L. Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components. American Journal of Human Genetics. 66: 1153-7. PMID 10712227 DOI: 10.1086/302830  0.48
2000 Friddle C, Koskela R, Ranade K, Hebert J, Cargill M, Clark CD, McInnis M, Simpson S, McMahon F, Stine OC, Meyers D, Xu J, MacKinnon D, Swift-Scanlan T, Jamison K, ... ... Kruglyak L, et al. Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype. American Journal of Human Genetics. 66: 205-15. PMID 10631152 DOI: 10.1086/302697  0.48
1999 Kruglyak L. Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nature Genetics. 22: 139-44. PMID 10369254 DOI: 10.1038/9642  0.48
1999 Kruglyak L. Genetic isolates: separate but equal? Proceedings of the National Academy of Sciences of the United States of America. 96: 1170-2. PMID 9989995 DOI: 10.1073/pnas.96.4.1170  0.48
1998 Perls TT, Bubrick E, Wager CG, Vijg J, Kruglyak L. Siblings of centenarians live longer. Lancet (London, England). 351: 1560. PMID 10326548 DOI: 10.1016/S0140-6736(05)61126-9  0.48
1998 McCarthy MI, Kruglyak L, Lander ES. Sib-pair collection strategies for complex diseases. Genetic Epidemiology. 15: 317-40. PMID 9671984 DOI: 10.1002/(SICI)1098-2272(1998)15:4<317::AID-GEPI1>3.0.CO;2-#  0.48
1998 Levinson DF, Mahtani MM, Nancarrow DJ, Brown DM, Kruglyak L, Kirby A, Hayward NK, Crowe RR, Andreasen NC, Black DW, Silverman JM, Endicott J, Sharpe L, Mohs RC, Siever LJ, et al. Genome scan of schizophrenia. The American Journal of Psychiatry. 155: 741-50. PMID 9619145  0.48
1998 Altshuler D, Kruglyak L, Lander E. Genetic polymorphisms and disease. The New England Journal of Medicine. 338: 1626. PMID 9606122 DOI: 10.1056/NEJM199805283382214  0.48
1998 Wang DG, Fan JB, Siao CJ, Berno A, Young P, Sapolsky R, Ghandour G, Perkins N, Winchester E, Spencer J, Kruglyak L, Stein L, Hsie L, Topaloglou T, Hubbell E, et al. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science (New York, N.Y.). 280: 1077-82. PMID 9582121 DOI: 10.1126/science.280.5366.1077  0.6
1998 Kruglyak L, Lander ES. Faster multipoint linkage analysis using Fourier transforms. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 5: 1-7. PMID 9541867  0.48
1998 Kruglyak L, Daly MJ. Linkage thresholds for two-stage genome scans. American Journal of Human Genetics. 62: 994-7. PMID 9529350 DOI: 10.1086/301792  0.48
1998 Kruglyak L, McAllister L. Who needs genetic markers? Nature Genetics. 18: 200-2. PMID 9500532 DOI: 10.1038/ng0398-200  0.48
1997 Daly M, Kirby A, Kruglyak L. Do multiple data sets provide support for a bipolar illness susceptibility locus on chromosome 18? Genetic Epidemiology. 14: 599-604. PMID 9433549 DOI: 10.1002/(SICI)1098-2272(1997)14:6<599::AID-GEPI8>3.0.CO;2-V  0.48
1997 Slonim D, Kruglyak L, Stein L, Lander E. Building human genome maps with radiation hybrids. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 4: 487-504. PMID 9385541  0.48
1997 Kruglyak L. What is significant in whole-genome linkage disequilibrium studies? American Journal of Human Genetics. 61: 810-2. PMID 9382090 DOI: 10.1086/514893  0.48
1997 Laitinen T, Kauppi P, Ignatius J, Ruotsalainen T, Daly MJ, Kääriäinen H, Kruglyak L, Laitinen H, de la Chapelle A, Lander ES, Laitinen LA, Kere J. Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population. Human Molecular Genetics. 6: 2069-76. PMID 9328470 DOI: 10.1093/hmg/6.12.2069  0.48
1997 Kruglyak L. The use of a genetic map of biallelic markers in linkage studies. Nature Genetics. 17: 21-4. PMID 9288093 DOI: 10.1038/ng0997-21  0.48
1997 Kruglyak L. Nonparametric linkage tests are model free. American Journal of Human Genetics. 61: 254-5. PMID 9246012 DOI: 10.1016/S0002-9297(07)64305-5  0.48
1997 Hamilton BA, Smith DJ, Mueller KL, Kerrebrock AW, Bronson RT, van Berkel V, Daly MJ, Kruglyak L, Reeve MP, Nemhauser JL, Hawkins TL, Rubin EM, Lander ES. The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 18: 711-22. PMID 9182797 DOI: 10.1016/S0896-6273(00)80312-8  0.48
1997 Freedman R, Coon H, Myles-Worsley M, Orr-Urtreger A, Olincy A, Davis A, Polymeropoulos M, Holik J, Hopkins J, Hoff M, Rosenthal J, Waldo MC, Reimherr F, Wender P, Yaw J, ... ... Kruglyak L, et al. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proceedings of the National Academy of Sciences of the United States of America. 94: 587-92. PMID 9012828 DOI: 10.1073/pnas.94.2.587  0.48
1996 Kruglyak L. Thresholds and sample sizes. Nature Genetics. 14: 132-3. PMID 8841180 DOI: 10.1038/ng1096-132  0.48
1996 Mahtani MM, Widén E, Lehto M, Thomas J, McCarthy M, Brayer J, Bryant B, Chan G, Daly M, Forsblom C, Kanninen T, Kirby A, Kruglyak L, Munnelly K, Parkkonen M, et al. Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nature Genetics. 14: 90-4. PMID 8782826 DOI: 10.1038/ng0996-90  0.48
1996 Gschwend M, Levran O, Kruglyak L, Ranade K, Verlander PC, Shen S, Faure S, Weissenbach J, Altay C, Lander ES, Auerbach AD, Botstein D. A locus for Fanconi anemia on 16q determined by homozygosity mapping. American Journal of Human Genetics. 59: 377-84. PMID 8755924  0.48
1996 Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. Parametric and nonparametric linkage analysis: a unified multipoint approach. American Journal of Human Genetics. 58: 1347-63. PMID 8651312  0.48
1996 Kruglyak L, Lander ES. Limits on fine mapping of complex traits. American Journal of Human Genetics. 58: 1092-3. PMID 8651271  0.48
1996 Levy EN, Shen Y, Kupelian A, Kruglyak L, Aksentijevich I, Pras E, Balow JE, Linzer B, Chen X, Shelton DA, Gumucio D, Pras M, Shohat M, Rotter JI, Fischel-Ghodsian N, et al. Linkage disequilibrium mapping places the gene causing familial Mediterranean fever close to D16S246. American Journal of Human Genetics. 58: 523-34. PMID 8644712  0.48
1996 Hamilton BA, Frankel WN, Kerrebrock AW, Hawkins TL, FitzHugh W, Kusumi K, Russell LB, Mueller KL, van Berkel V, Birren BW, Kruglyak L, Lander ES. Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature. 379: 736-9. PMID 8602221 DOI: 10.1038/379736a0  0.48
1996 Dietrich WF, Miller J, Steen R, Merchant MA, Damron-Boles D, Husain Z, Dredge R, Daly MJ, Ingalls KA, O'Connor TJ, Evans CA, DeAngelis MM, Levinson DM, Kruglyak L, Goodman N, et al. A comprehensive genetic map of the mouse genome Nature. 380: 149-152. PMID 8600386 DOI: 10.1038/380149a0  0.48
1996 Hamilton BA, Frankel WN, Kerrebrock AW, Hawkins TL, FitzHugh W, Kusumi K, Russell LB, Mueller KL, Van Berkel V, Birren BW, Kruglyak L, Lander ES. Correction: Disruption of the nuclear hormone receptor RORα in staggerer mice (Nature Journal (1996) 379 (736-739)) Nature. 381: 346.  0.48
1996 Dietrich WF, Miller J, Steen R, Merchant MA, Damron-Boles D, Husain Z, Dredge R, Daly MJ, Ingalls KA, O'Connor TJ, Evans CA, DeAngelis MM, Levinson DM, Kruglyak L, Goodman N, et al. Correction: A comprehensive genetic map of the mouse genome (Nature (1996) 380 (149-152)) Nature. 381: 172.  0.48
1995 Hudson TJ, Stein LD, Gerety SS, Ma J, Castle AB, Silva J, Slonim DK, Baptista R, Kruglyak L, Xu SH, Hu X, Colbert AM, Rosenberg C, Reeve-Daly MP, Rozen S, et al. An STS-based map of the human genome. Science (New York, N.Y.). 270: 1945-54. PMID 8533086  0.48
1995 Kruglyak L, Daly MJ, Lander ES. Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. American Journal of Human Genetics. 56: 519-27. PMID 7847388  0.48
1995 Kruglyak L, Lander ES. A nonparametric approach for mapping quantitative trait loci. Genetics. 139: 1421-8. PMID 7768449  0.48
1995 Kruglyak L, Lander ES. High-resolution genetic mapping of complex traits. American Journal of Human Genetics. 56: 1212-23. PMID 7726179  0.48
1995 Kruglyak L, Lander ES. Complete multipoint sib-pair analysis of qualitative and quantitative traits. American Journal of Human Genetics. 57: 439-54. PMID 7668271  0.48
1995 Hu S, Pattatucci AM, Patterson C, Li L, Fulker DW, Cherny SS, Kruglyak L, Hamer DH. Linkage between sexual orientation and chromosome Xq28 in males but not in females. Nature Genetics. 11: 248-56. PMID 7581447 DOI: 10.1038/ng1195-248  0.48
1995 Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genetics. 11: 241-7. PMID 7581446 DOI: 10.1038/ng1195-241  0.48
1993 Kruglyak L. Sexual orientation. Nature. 365: 702. PMID 8413649 DOI: 10.1038/365702c0  0.48
1987 Affleck I, Kruglyak L. Photon splitting in a plane-wave field. Physical Review Letters. 59: 1065-1068. PMID 10035131 DOI: 10.1103/PhysRevLett.59.1065  0.48
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