| Year |
Citation |
Score |
| 2023 |
Levring J, Terry DS, Kilic Z, Fitzgerald G, Blanchard S, Chen J. CFTR function, pathology and pharmacology at single-molecule resolution. Nature. PMID 36949202 DOI: 10.1038/s41586-023-05854-7 |
0.327 |
|
| 2023 |
Pietz HL, Abbas A, Johnson ZL, Oldham ML, Suga H, Chen J. A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation. Proceedings of the National Academy of Sciences of the United States of America. 120: e2220012120. PMID 36893260 DOI: 10.1073/pnas.2220012120 |
0.817 |
|
| 2022 |
Zhao H, Lee J, Chen J. The hemolysin A secretion system is a multi-engine pump containing three ABC transporters. Cell. 185: 3329-3340.e13. PMID 36055198 DOI: 10.1016/j.cell.2022.07.017 |
0.387 |
|
| 2022 |
Kieuvongngam V, Chen J. Structures of the peptidase-containing ABC transporter PCAT1 under equilibrium and nonequilibrium conditions. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35074919 DOI: 10.1073/pnas.2120534119 |
0.502 |
|
| 2021 |
Liu F, Lee J, Chen J. Molecular structures of the eukaryotic retinal importer ABCA4. Elife. 10. PMID 33605212 DOI: 10.7554/eLife.63524 |
0.386 |
|
| 2020 |
Wang L, Johnson ZL, Wasserman MR, Levring J, Chen J, Liu S. Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses. Elife. 9. PMID 32458799 DOI: 10.7554/Elife.56451 |
0.795 |
|
| 2020 |
Kieuvongngam V, Olinares PDB, Palillo A, Oldham ML, Chait BT, Chen J. Structural basis of substrate recognition by a polypeptide processing and secretion transporter. Elife. 9. PMID 31934861 DOI: 10.7554/Elife.51492 |
0.793 |
|
| 2020 |
Wang L, Johnson ZL, Wasserman MR, Levring J, Chen J, Liu S. Author response: Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses Elife. DOI: 10.7554/Elife.56451.Sa2 |
0.4 |
|
| 2020 |
Wang L, Johnson ZL, Wasserman MR, Levring J, Chen J, Liu S. Conformational Dynamics of Multidrug Resistance Protein 1 During Active Transport Biophysical Journal. 118: 528a. DOI: 10.1016/J.Bpj.2019.11.2900 |
0.722 |
|
| 2019 |
Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J. Structural identification of a hotspot on CFTR for potentiation. Science (New York, N.Y.). 364: 1184-1188. PMID 31221859 DOI: 10.2210/Pdb6O1V/Pdb |
0.318 |
|
| 2019 |
Kieuvongngam V, Olinares PDB, Palillo A, Oldham ML, Chait BT, Chen J. Author response: Structural basis of substrate recognition by a polypeptide processing and secretion transporter Elife. DOI: 10.7554/Elife.51492.Sa2 |
0.737 |
|
| 2018 |
Zhang Z, Liu F, Chen J. Molecular structure of the ATP-bound, phosphorylated human CFTR. Proceedings of the National Academy of Sciences of the United States of America. PMID 30459277 DOI: 10.1073/Pnas.1815287115 |
0.416 |
|
| 2018 |
Kim Y, Chen J. Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation. Science (New York, N.Y.). PMID 29371429 DOI: 10.1126/Science.Aar7389 |
0.515 |
|
| 2017 |
Johnson ZL, Chen J. ATP Binding Enables Substrate Release from Multidrug Resistance Protein 1. Cell. PMID 29290467 DOI: 10.1016/J.Cell.2017.12.005 |
0.764 |
|
| 2017 |
Lee KPK, Chen J, MacKinnon R. Molecular structure of human KATP in complex with ATP and ADP. Elife. 6. PMID 29286281 DOI: 10.7554/Elife.32481 |
0.448 |
|
| 2017 |
Zhang Z, Liu F, Chen J. Conformational Changes of CFTR upon Phosphorylation and ATP Binding. Cell. 170: 483-491.e8. PMID 28735752 DOI: 10.1016/J.Cell.2017.06.041 |
0.491 |
|
| 2017 |
Liu F, Zhang Z, Csanády L, Gadsby DC, Chen J. Molecular Structure of the Human CFTR Ion Channel. Cell. 169: 85-95.e8. PMID 28340353 DOI: 10.1016/J.Cell.2017.02.024 |
0.427 |
|
| 2017 |
Johnson ZL, Chen J. Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1. Cell. PMID 28238471 DOI: 10.1016/J.Cell.2017.01.041 |
0.774 |
|
| 2016 |
Oldham ML, Grigorieff N, Chen J. Structure of the transporter associated with antigen processing trapped by herpes simplex virus. Elife. 5. PMID 27935481 DOI: 10.7554/Elife.21829 |
0.756 |
|
| 2016 |
Zhang Z, Chen J. Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator. Cell. 167: 1586-1597.e9. PMID 27912062 DOI: 10.1016/J.Cell.2016.11.014 |
0.413 |
|
| 2016 |
Oldham ML, Hite RK, Steffen AM, Damko E, Li Z, Walz T, Chen J. A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter. Nature. PMID 26789246 DOI: 10.1038/Nature16506 |
0.744 |
|
| 2016 |
Oldham ML, Grigorieff N, Chen J. Author response: Structure of the transporter associated with antigen processing trapped by herpes simplex virus Elife. DOI: 10.7554/Elife.21829.013 |
0.716 |
|
| 2015 |
Lin DY, Huang S, Chen J. Crystal structures of a polypeptide processing and secretion transporter. Nature. 523: 425-30. PMID 26201595 DOI: 10.1038/Nature14623 |
0.556 |
|
| 2015 |
Lin DYW, Huang S, Chen J. Crystal structures of a polypeptide processing and secretion transporter Nature. 523: 425-430. DOI: 10.1038/nature14623 |
0.466 |
|
| 2013 |
Oldham ML, Chen S, Chen J. Structural basis for substrate specificity in the Escherichia coli maltose transport system. Proceedings of the National Academy of Sciences of the United States of America. 110: 18132-7. PMID 24145421 DOI: 10.1073/Pnas.1311407110 |
0.796 |
|
| 2013 |
Chen S, Oldham ML, Davidson AL, Chen J. Carbon catabolite repression of the maltose transporter revealed by X-ray crystallography. Nature. 499: 364-8. PMID 23770568 DOI: 10.1038/Nature12232 |
0.766 |
|
| 2013 |
Chen J. Molecular mechanism of the Escherichia coli maltose transporter. Current Opinion in Structural Biology. 23: 492-8. PMID 23628288 DOI: 10.1016/J.Sbi.2013.03.011 |
0.551 |
|
| 2012 |
Jin MS, Oldham ML, Zhang Q, Chen J. Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans. Nature. 490: 566-9. PMID 23000902 DOI: 10.1038/Nature11448 |
0.765 |
|
| 2011 |
Oldham ML, Chen J. Snapshots of the maltose transporter during ATP hydrolysis. Proceedings of the National Academy of Sciences of the United States of America. 108: 15152-6. PMID 21825153 DOI: 10.1073/Pnas.1108858108 |
0.781 |
|
| 2011 |
Oldham ML, Chen J. Crystal structure of the maltose transporter in a pretranslocation intermediate state. Science (New York, N.Y.). 332: 1202-5. PMID 21566157 DOI: 10.1126/Science.1200767 |
0.784 |
|
| 2011 |
Kim HC, Steffen AM, Oldham ML, Chen J, Huibregtse JM. Structure and function of a HECT domain ubiquitin-binding site. Embo Reports. 12: 334-41. PMID 21399621 DOI: 10.1038/Embor.2011.23 |
0.729 |
|
| 2011 |
Lin DY, Diao J, Zhou D, Chen J. Biochemical and structural studies of a HECT-like ubiquitin ligase from Escherichia coli O157:H7. The Journal of Biological Chemistry. 286: 441-9. PMID 20980253 DOI: 10.1074/Jbc.M110.167643 |
0.39 |
|
| 2010 |
Orelle C, Alvarez FJ, Oldham ML, Orelle A, Wiley TE, Chen J, Davidson AL. Dynamics of alpha-helical subdomain rotation in the intact maltose ATP-binding cassette transporter. Proceedings of the National Academy of Sciences of the United States of America. 107: 20293-8. PMID 21059948 DOI: 10.1073/Pnas.1006544107 |
0.776 |
|
| 2009 |
Yu IM, Holdaway HA, Chipman PR, Kuhn RJ, Rossmann MG, Chen J. Association of the pr peptides with dengue virus at acidic pH blocks membrane fusion. Journal of Virology. 83: 12101-7. PMID 19759134 DOI: 10.1128/Jvi.01637-09 |
0.642 |
|
| 2009 |
Khare D, Oldham ML, Orelle C, Davidson AL, Chen J. Alternating access in maltose transporter mediated by rigid-body rotations. Molecular Cell. 33: 528-36. PMID 19250913 DOI: 10.1016/J.Molcel.2009.01.035 |
0.789 |
|
| 2008 |
Oldham ML, Davidson AL, Chen J. Structural insights into ABC transporter mechanism. Current Opinion in Structural Biology. 18: 726-33. PMID 18948194 DOI: 10.1016/J.Sbi.2008.09.007 |
0.789 |
|
| 2008 |
Davidson AL, Dassa E, Orelle C, Chen J. Structure, function, and evolution of bacterial ATP-binding cassette systems. Microbiology and Molecular Biology Reviews : Mmbr. 72: 317-64, table of con. PMID 18535149 DOI: 10.1128/Mmbr.00031-07 |
0.561 |
|
| 2008 |
Yu IM, Zhang W, Holdaway HA, Li L, Kostyuchenko VA, Chipman PR, Kuhn RJ, Rossmann MG, Chen J. Structure of the immature dengue virus at low pH primes proteolytic maturation. Science (New York, N.Y.). 319: 1834-7. PMID 18369148 DOI: 10.1126/Science.1153264 |
0.655 |
|
| 2008 |
Li L, Lok SM, Yu IM, Zhang Y, Kuhn RJ, Chen J, Rossmann MG. The flavivirus precursor membrane-envelope protein complex: structure and maturation. Science (New York, N.Y.). 319: 1830-4. PMID 18369147 DOI: 10.1126/Science.1153263 |
0.676 |
|
| 2008 |
Diao J, Zhang Y, Huibregtse JM, Zhou D, Chen J. Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase. Nature Structural & Molecular Biology. 15: 65-70. PMID 18066077 DOI: 10.1038/Nsmb1346 |
0.417 |
|
| 2007 |
Oldham ML, Khare D, Quiocho FA, Davidson AL, Chen J. Crystal structure of a catalytic intermediate of the maltose transporter. Nature. 450: 515-21. PMID 18033289 DOI: 10.1038/Nature06264 |
0.808 |
|
| 2006 |
Yu IM, Oldham ML, Zhang J, Chen J. Crystal structure of the severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein dimerization domain reveals evolutionary linkage between corona- and arteriviridae. The Journal of Biological Chemistry. 281: 17134-9. PMID 16627473 DOI: 10.1074/Jbc.M602107200 |
0.768 |
|
| 2005 |
Lu G, Westbrooks JM, Davidson AL, Chen J. ATP hydrolysis is required to reset the ATP-binding cassette dimer into the resting-state conformation. Proceedings of the National Academy of Sciences of the United States of America. 102: 17969-74. PMID 16326809 DOI: 10.1073/Pnas.0506039102 |
0.566 |
|
| 2005 |
Davidson AL, Chen J. Structural biology. Flipping lipids: is the third time the charm? Science (New York, N.Y.). 308: 963-5. PMID 15890866 DOI: 10.1126/Science.1113414 |
0.314 |
|
| 2005 |
Yu IM, Gustafson CL, Diao J, Burgner JW, Li Z, Zhang J, Chen J. Recombinant severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein forms a dimer through its C-terminal domain. The Journal of Biological Chemistry. 280: 23280-6. PMID 15849181 DOI: 10.1074/Jbc.M501015200 |
0.644 |
|
| 2005 |
Chang J, Chen J, Zhou D. Delineation and characterization of the actin nucleation and effector translocation activities of Salmonella SipC. Molecular Microbiology. 55: 1379-89. PMID 15720547 DOI: 10.1111/J.1365-2958.2004.04480.X |
0.306 |
|
| 2004 |
Davidson AL, Chen J. ATP-binding cassette transporters in bacteria. Annual Review of Biochemistry. 73: 241-68. PMID 15189142 DOI: 10.1146/Annurev.Biochem.73.011303.073626 |
0.514 |
|
| 2003 |
Chen J, Lu G, Lin J, Davidson AL, Quiocho FA. A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle. Molecular Cell. 12: 651-61. PMID 14527411 DOI: 10.1016/J.Molcel.2003.08.004 |
0.636 |
|
| 2003 |
Samanta S, Ayvaz T, Reyes M, Shuman HA, Chen J, Davidson AL. Disulfide cross-linking reveals a site of stable interaction between C-terminal regulatory domains of the two MalK subunits in the maltose transport complex. The Journal of Biological Chemistry. 278: 35265-71. PMID 12813052 DOI: 10.1074/Jbc.M301171200 |
0.505 |
|
| 2001 |
Mao Y, Chen J, Maynard JA, Zhang B, Quiocho FA. A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis. Cell. 104: 433-40. PMID 11239400 DOI: 10.1016/S0092-8674(01)00230-6 |
0.539 |
|
| 2001 |
Chen J, Sharma S, Quiocho FA, Davidson AL. Trapping the transition state of an ATP-binding cassette transporter: evidence for a concerted mechanism of maltose transport. Proceedings of the National Academy of Sciences of the United States of America. 98: 1525-30. PMID 11171984 DOI: 10.1073/Pnas.98.4.1525 |
0.647 |
|
| 2000 |
Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA. Evolution of shape complementarity and catalytic efficiency from a primordial antibody template. Science (New York, N.Y.). 286: 2345-8. PMID 10600746 DOI: 10.1126/Science.286.5448.2345 |
0.333 |
|
| 1999 |
Chen J, Skehel JJ, Wiley DC. N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA(2) subunit to form an N cap that terminates the triple-stranded coiled coil. Proceedings of the National Academy of Sciences of the United States of America. 96: 8967-72. PMID 10430879 DOI: 10.1073/Pnas.96.16.8967 |
0.594 |
|
| 1998 |
Chen J, Lee KH, Steinhauer DA, Stevens DJ, Skehel JJ, Wiley DC. Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation. Cell. 95: 409-17. PMID 9814710 DOI: 10.1016/S0092-8674(00)81771-7 |
0.593 |
|
| 1998 |
Chen J, Skehel JJ, Wiley DC. A polar octapeptide fused to the N-terminal fusion peptide solubilizes the influenza virus HA2 subunit ectodomain. Biochemistry. 37: 13643-9. PMID 9753451 DOI: 10.1021/Bi981098L |
0.596 |
|
| 1997 |
Hall JA, Ganesan AK, Chen J, Nikaido H. Two modes of ligand binding in maltose-binding protein of Escherichia coli: Functional significance in active transport Journal of Biological Chemistry. 272: 17615-17622. PMID 9211910 DOI: 10.1074/Jbc.272.28.17615 |
0.379 |
|
| 1995 |
Chen J, Wharton SA, Weissenhorn W, Calder LJ, Hughson FM, Skehel JJ, Wiley DC. A soluble domain of the membrane-anchoring chain of influenza virus hemagglutinin (HA2) folds in Escherichia coli into the low-pH-induced conformation. Proceedings of the National Academy of Sciences of the United States of America. 92: 12205-9. PMID 8618870 DOI: 10.1073/Pnas.92.26.12205 |
0.727 |
|
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