| Year |
Citation |
Score |
| 2023 |
Wang C, Hucik B, Sarr O, Brown LH, Wells KRD, Brunt KR, Nakamura MT, Harasim-Symbor E, Chabowski A, Mutch DM. Delta-6 desaturase (Fads2) deficiency alters triacylglycerol / fatty acid cycling in murine white adipose tissue. Journal of Lipid Research. 100376. PMID 37085033 DOI: 10.1016/j.jlr.2023.100376 |
0.445 |
|
| 2023 |
Budd JM, Hucik B, Wang C, King A, Sarr O, Nakamura MT, Harasim-Symbor E, Chabowski A, Dyck DJ, Mutch DM. A reduction of skeletal muscle DHA content does not result in impaired whole-body glucose tolerance or skeletal muscle basal insulin signaling in healthy mice. American Journal of Physiology. Endocrinology and Metabolism. PMID 36696599 DOI: 10.1152/ajpendo.00308.2022 |
0.367 |
|
| 2020 |
Harauma A, Sueyasu T, Tokuda H, Yasuda H, Hoshi Y, Kaneda Y, Rogi T, Shibata H, Nakamura MT, Moriguchi T. Changes in behavior and fatty acid composition induced by long-term reduction in murine Δ6-desaturation activity. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 155: 102079. PMID 32145668 DOI: 10.1016/J.Plefa.2020.102079 |
0.479 |
|
| 2020 |
Caputo MP, Williams JN, Drnevich J, Radlowski EC, Larsen RJ, Sutton BP, Leyshon BJ, Hussain J, Nakamura MT, Kuchan MJ, Das T, Johnson RW. Hydrolyzed Fat Formula Increases Brain White Matter in Small for Gestational Age and Appropriate for Gestational Age Neonatal Piglets. Frontiers in Pediatrics. 8: 32. PMID 32117837 DOI: 10.3389/Fped.2020.00032 |
0.351 |
|
| 2020 |
Zapata FJ, Rebollo-Hernanz M, Novakofski JE, Nakamura MT, Gonzalez de Mejia E. Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-sucrose-diet-driven lipogenesis and body fat accumulation Journal of Functional Foods. 64: 103646. DOI: 10.1016/J.Jff.2019.103646 |
0.51 |
|
| 2019 |
Hucik B, Sarr O, Nakamura MT, Dyck DJ, Mutch DM. Reduced delta-6 desaturase activity partially protects against high-fat diet-induced impairment in whole-body glucose tolerance. The Journal of Nutritional Biochemistry. 67: 173-181. PMID 30928647 DOI: 10.1016/J.Jnutbio.2019.02.005 |
0.535 |
|
| 2018 |
Sarr O, Payne GW, Hucik B, Abdelmagid S, Nakamura MT, Ma DWL, Mutch DM. Dietary EPA and DHA prevent changes in white adipose tissue omega-3 PUFA and oxylipin content associated with a Fads2 deficiency. The Journal of Nutritional Biochemistry. 63: 140-149. PMID 30368227 DOI: 10.1016/J.Jnutbio.2018.09.017 |
0.491 |
|
| 2018 |
Burns JL, Nakamura MT, Ma DWL. Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 135: 1-4. PMID 30103919 DOI: 10.1016/J.Plefa.2018.05.004 |
0.405 |
|
| 2017 |
Harauma A, Hatanaka E, Yasuda H, Nakamura MT, Salem N, Moriguchi T. Effects of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid on brain development using artificial rearing of delta-6-desaturase knockout mice. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 127: 32-39. PMID 29156156 DOI: 10.1016/J.Plefa.2017.10.001 |
0.425 |
|
| 2017 |
Suitor K, Payne GW, Sarr O, Abdelmagid S, Nakamura MT, Ma DW, Mutch DM. Neither linoleic acid nor arachidonic acid promote white adipose tissue inflammation in Fads2-/- mice fed low fat diets. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 126: 84-91. PMID 29031400 DOI: 10.1016/J.Plefa.2017.09.008 |
0.458 |
|
| 2017 |
Harauma A, Yasuda H, Hatanaka E, Nakamura MT, Salem N, Moriguchi T. The essentiality of arachidonic acid in addition to docosahexaenoic acid for brain growth and function. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 116: 9-18. PMID 28088293 DOI: 10.1016/J.Plefa.2016.11.002 |
0.411 |
|
| 2016 |
Su H, Zhou D, Pan YX, Wang X, Nakamura MT. Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio. Journal of Lipid Research. 57: 1995-2004. PMID 27613800 DOI: 10.1194/Jlr.M064956 |
0.435 |
|
| 2016 |
Hatanaka E, Harauma A, Yasuda H, Watanabe J, Nakamura MT, Salem N, Moriguchi T. Essentiality of arachidonic acid intake in murine early development. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 108: 51-7. PMID 27154365 DOI: 10.1016/J.Plefa.2016.03.007 |
0.416 |
|
| 2016 |
Monk JM, Liddle DM, Cohen DJ, Tsang DH, Hillyer LM, Abdelmagid SA, Nakamura MT, Power KA, Ma DW, Robinson LE. The delta 6 desaturase knock out mouse reveals that immunomodulatory effects of essential n-6 and n-3 polyunsaturated fatty acids are both independent of and dependent upon conversion. The Journal of Nutritional Biochemistry. 32: 29-38. PMID 27142734 DOI: 10.1016/J.Jnutbio.2016.01.004 |
0.393 |
|
| 2014 |
Nakamura MT, Yudell BE, Loor JJ. Regulation of energy metabolism by long-chain fatty acids. Progress in Lipid Research. 53: 124-44. PMID 24362249 DOI: 10.1016/J.Plipres.2013.12.001 |
0.651 |
|
| 2013 |
Monteiro J, Askarian F, Nakamura MT, Moghadasian MH, Ma DW. Oils rich in α-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse. Canadian Journal of Physiology and Pharmacology. 91: 469-79. PMID 23746194 DOI: 10.1139/Cjpp-2012-0308 |
0.448 |
|
| 2012 |
Monteiro J, Li FJ, Maclennan M, Rabalski A, Moghadasian MH, Nakamura MT, Ma DW. Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. Lipids in Health and Disease. 11: 60. PMID 22642787 DOI: 10.1186/1476-511X-11-60 |
0.446 |
|
| 2011 |
Roqueta-Rivera M, Abbott TL, Sivaguru M, Hess RA, Nakamura MT. Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice. Biology of Reproduction. 85: 721-32. PMID 21653892 DOI: 10.1095/Biolreprod.110.089524 |
0.382 |
|
| 2010 |
Cho BH, Park JR, Nakamura MT, Odintsov BM, Wallig MA, Chung BH. Synthetic dimyristoylphosphatidylcholine liposomes assimilating into high-density lipoprotein promote regression of atherosclerotic lesions in cholesterol-fed rabbits. Experimental Biology and Medicine (Maywood, N.J.). 235: 1194-203. PMID 20876082 DOI: 10.1258/Ebm.2010.009320 |
0.307 |
|
| 2010 |
Rosenblat M, Volkova N, Roqueta-Rivera M, Nakamura MT, Aviram M. Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Delta6-desaturase knockout (6-DS KO) mice: beneficial effects of arachidonic acid. Atherosclerosis. 210: 414-21. PMID 20042190 DOI: 10.1016/J.Atherosclerosis.2009.11.044 |
0.403 |
|
| 2010 |
Roqueta-Rivera M, Stroud CK, Haschek WM, Akare SJ, Segre M, Brush RS, Agbaga MP, Anderson RE, Hess RA, Nakamura MT. Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice. Journal of Lipid Research. 51: 360-7. PMID 19690334 DOI: 10.1194/Jlr.M001180 |
0.459 |
|
| 2009 |
Koo HY, Miyashita M, Cho BH, Nakamura MT. Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus. Biochemical and Biophysical Research Communications. 390: 285-9. PMID 19799862 DOI: 10.1016/J.Bbrc.2009.09.109 |
0.48 |
|
| 2009 |
Stroud CK, Nara TY, Roqueta-Rivera M, Radlowski EC, Lawrence P, Zhang Y, Cho BH, Segre M, Hess RA, Brenna JT, Haschek WM, Nakamura MT. Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration. Journal of Lipid Research. 50: 1870-80. PMID 19351970 DOI: 10.1194/Jlr.M900039-Jlr200 |
0.429 |
|
| 2008 |
Koo HY, Wallig MA, Chung BH, Nara TY, Cho BH, Nakamura MT. Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver. Biochimica Et Biophysica Acta. 1782: 341-8. PMID 18346472 DOI: 10.1016/J.Bbadis.2008.02.007 |
0.539 |
|
| 2007 |
Stroud CK, Nara TY, Haschek WM, Cho BS, Nakamura MT. Delta‐6 desaturase knockout mouse illustrates previously undocumented pathology The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A701 |
0.414 |
|
| 2007 |
Liu A, Nakamura MT, Yudell BE, Erdman JW. Short term consumption of lycopene and phytofluene decreases PPAR{alpha} and PPAR{gamma} expression in selected rat tissues The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A48-C |
0.322 |
|
| 2006 |
Campbell JK, Stroud CK, Nakamura MT, Lila MA, Erdman JW. Serum testosterone is reduced following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats. The Journal of Nutrition. 136: 2813-9. PMID 17056806 DOI: 10.1093/Jn/136.11.2813 |
0.327 |
|
| 2006 |
Adamson AW, Suchankova G, Rufo C, Nakamura MT, Teran-Garcia M, Clarke SD, Gettys TW. Hepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase. The Biochemical Journal. 399: 285-95. PMID 16800817 DOI: 10.1042/Bj20060659 |
0.422 |
|
| 2006 |
Baum JI, Layman DK, Freund GG, Rahn KA, Nakamura MT, Yudell BE. A reduced carbohydrate, increased protein diet stabilizes glycemic control and minimizes adipose tissue glucose disposal in rats. The Journal of Nutrition. 136: 1855-61. PMID 16772449 DOI: 10.1093/Jn/136.7.1855 |
0.65 |
|
| 2006 |
Zaripheh S, Nara TY, Nakamura MT, Erdman JW. Dietary lycopene downregulates carotenoid 15,15'-monooxygenase and PPAR-gamma in selected rat tissues. The Journal of Nutrition. 136: 932-8. PMID 16549453 DOI: 10.1093/Jn/136.4.932 |
0.436 |
|
| 2005 |
Li Y, Nara TY, Nakamura MT. Peroxisome proliferator-activated receptor alpha is required for feedback regulation of highly unsaturated fatty acid synthesis. Journal of Lipid Research. 46: 2432-40. PMID 16106047 DOI: 10.1194/Jlr.M500237-Jlr200 |
0.465 |
|
| 2005 |
Cheon Y, Nara TY, Band MR, Beever JE, Wallig MA, Nakamura MT. Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPARalpha in nonproliferating species. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 288: R1525-35. PMID 15650118 DOI: 10.1152/Ajpregu.00751.2004 |
0.663 |
|
| 2004 |
Nakamura MT, Cheon Y, Li Y, Nara TY. Mechanisms of regulation of gene expression by fatty acids. Lipids. 39: 1077-83. PMID 15726822 DOI: 10.1007/S11745-004-1333-0 |
0.676 |
|
| 2004 |
Nakamura MT, Nara TY. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annual Review of Nutrition. 24: 345-76. PMID 15189125 DOI: 10.1146/Annurev.Nutr.24.121803.063211 |
0.447 |
|
| 2003 |
Tang C, Cho HP, Nakamura MT, Clarke SD. Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element. Journal of Lipid Research. 44: 686-95. PMID 12562861 DOI: 10.1194/Jlr.M200195-Jlr200 |
0.377 |
|
| 2003 |
Nakamura MT, Nara TY. Essential fatty acid synthesis and its regulation in mammals. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 68: 145-50. PMID 12538078 DOI: 10.1016/S0952-3278(02)00264-8 |
0.45 |
|
| 2003 |
Nakamura MT, Nara TY. Gene regulation of mammalian desaturases. Biochemical Society Transactions. 30: 1076-9. PMID 12440976 DOI: 10.1042/Bst0301076 |
0.504 |
|
| 2002 |
Song He W, Nara TY, Nakamura MT. Delayed induction of delta-6 and delta-5 desaturases by a peroxisome proliferator. Biochemical and Biophysical Research Communications. 299: 832-8. PMID 12470654 DOI: 10.1016/S0006-291X(02)02743-2 |
0.483 |
|
| 2002 |
Nara TY, He WS, Tang C, Clarke SD, Nakamura MT. The E-box like sterol regulatory element mediates the suppression of human Delta-6 desaturase gene by highly unsaturated fatty acids. Biochemical and Biophysical Research Communications. 296: 111-7. PMID 12147235 DOI: 10.1016/S0006-291X(02)00851-3 |
0.414 |
|
| 2002 |
Teran-Garcia M, Rufo C, Nakamura MT, Osborne TF, Clarke SD. NF-Y involvement in the polyunsaturated fat inhibition of fatty acid synthase gene transcription. Biochemical and Biophysical Research Communications. 290: 1295-9. PMID 11812004 DOI: 10.1006/Bbrc.2002.6341 |
0.451 |
|
| 2001 |
Rufo C, Teran-Garcia M, Nakamura MT, Koo SH, Towle HC, Clarke SD. Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription. The Journal of Biological Chemistry. 276: 21969-75. PMID 11279238 DOI: 10.1074/Jbc.M100461200 |
0.508 |
|
| 2001 |
Xu J, Teran-Garcia M, Park JH, Nakamura MT, Clarke SD. Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay. The Journal of Biological Chemistry. 276: 9800-7. PMID 11124951 DOI: 10.1074/Jbc.M008973200 |
0.39 |
|
| 2000 |
Nakamura MT, Cho HP, Clarke SD. Regulation of hepatic Δ-6 desaturase expression and its role in the polyunsaturated fatty acid inhibition of fatty acid synthase gene expression in mice Journal of Nutrition. 130: 1561-1565. PMID 10827210 DOI: 10.1093/Jn/130.6.1561 |
0.507 |
|
| 2000 |
Nakamura MT. The Return of ω3 Fatty Acids into the Food Supply I. Land-Based Animal Food Products and Their Health Effects The American Journal of Clinical Nutrition. 71: 1215-1216. DOI: 10.1093/Ajcn/71.5.1215 |
0.309 |
|
| 1999 |
Cho HP, Nakamura M, Clarke SD. Cloning, expression, and fatty acid regulation of the human Δ-5 desaturase Journal of Biological Chemistry. 274: 37335-37339. PMID 10601301 DOI: 10.1074/Jbc.274.52.37335 |
0.44 |
|
| 1999 |
Baillie RA, Takada R, Nakamura M, Clarke SD. Coordinate induction of peroxisomal acyl-CoA oxidase and UCP-3 by dietary fish oil: A mechanism for decreased body fat deposition Prostaglandins Leukotrienes and Essential Fatty Acids. 60: 351-356. PMID 10471120 DOI: 10.1016/S0952-3278(99)80011-8 |
0.443 |
|
| 1999 |
Xu J, Nakamura MT, Cho HP, Clarke SD. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats Journal of Biological Chemistry. 274: 23577-23583. PMID 10438539 DOI: 10.1074/Jbc.274.33.23577 |
0.483 |
|
| 1999 |
Rufo C, Gasperikova D, Clarke SD, Teran-Garcia M, Nakamura MT. Identification of a novel enhancer sequence in the distal promoter of the rat fatty acid synthase gene Biochemical and Biophysical Research Communications. 261: 400-405. PMID 10425197 DOI: 10.1006/Bbrc.1999.1034 |
0.443 |
|
| 1999 |
Cho HP, Nakamura MT, Clarke SD. Cloning, expression, and nutritional regulation of the mammalian Δ-6 desaturase Journal of Biological Chemistry. 274: 471-477. PMID 9867867 DOI: 10.1074/Jbc.274.1.471 |
0.408 |
|
| 1997 |
Clarke SD, Baillie R, Jump DB, Nakamura MT. Fatty acid regulation of gene expression. Its role in fuel partitioning and insulin resistance Annals of the New York Academy of Sciences. 827: 178-187. PMID 9329753 DOI: 10.1111/J.1749-6632.1997.Tb51833.X |
0.499 |
|
| 1996 |
Nakamura MT, Phinney SD, Tang AB, Oberbauer AM, German JB, Murray JD. Increased hepatic delta 6-desaturase activity with growth hormone expression in the MG101 transgenic mouse. Lipids. 31: 139-43. PMID 8835400 DOI: 10.1007/Bf02522612 |
0.668 |
|
| 1996 |
German J, Xu R, Walzem R, Kinsella JE, Knuckles B, Nakamura M, Yokoyama WH. Effect of dietary fats and barley fiber on total cholesterol and lipoprotein cholesterol distribution in plasma of hamsters Nutrition Research. 16: 1239-1249. DOI: 10.1016/0271-5317(96)00127-3 |
0.348 |
|
| 1994 |
Nakamura MT, Tang AB, Villanueva J, Halsted CH, Phinney SD. Selective reduction of delta 6 and delta 5 desaturase activities but not delta 9 desaturase in micropigs chronically fed ethanol. The Journal of Clinical Investigation. 93: 450-4. PMID 8282819 DOI: 10.1172/Jci116981 |
0.641 |
|
| 1994 |
Villanueva J, Chandler CJ, Shimasaki N, Tang AB, Nakamura M, Phinney SD, Halsted CH. Effects of ethanol feeding on liver, kidney and jejunal membranes of micropigs. Hepatology (Baltimore, Md.). 19: 1229-40. PMID 8175146 DOI: 10.1002/Hep.1840190522 |
0.618 |
|
| 1993 |
Thurmond DC, Tang AB, Nakamura MT, Stern JS, Phinney SD. Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats Obesity Research.. 1: 118-125. PMID 16353349 DOI: 10.1002/J.1550-8528.1993.Tb00600.X |
0.635 |
|
| 1993 |
Phinney SD, Tang AB, Thurmond DC, Nakamura MT, Stern JS. Abnormal polyunsaturated lipid metabolism in the obese Zucker rat, with partial metabolic correction by γ-linolenic acid administration Metabolism. 42: 1127-1140. PMID 8412765 DOI: 10.1016/0026-0495(93)90270-X |
0.639 |
|
| 1993 |
Nakamura MT, Tang AB, Villanueva J, Halsted CH, Phinney SD. The body composition and lipid metabolic effects of long-term ethanol feeding during a high omega 6 polyunsaturated fatty acid diet in micropigs. Metabolism: Clinical and Experimental. 42: 1340-50. PMID 8412749 DOI: 10.1016/0026-0495(93)90136-C |
0.679 |
|
| 1992 |
Nakamura MT, Tang AB, Villanueva J, Halsted CH, Phinney SD. Reduced tissue arachidonic acid concentration with chronic ethanol feeding in miniature pigs. The American Journal of Clinical Nutrition. 56: 467-74. PMID 1503056 DOI: 10.1093/Ajcn/56.3.467 |
0.672 |
|
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