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Christopher D. Bahl, MS, PhD - Publications

Affiliations: 
2005-2006 Molecular & Biomedical Sciences The University of Maine, Orono, ME, United States 
 2006-2012 Biochemistry Geisel School of Medicine at Dartmouth, Hanover, NH, United States 
 2012-2017 Biochemistry University of Washington, Seattle, Seattle, WA 
 2017- Protein Design Institute for Protein Innovation 
Area:
Biochemistry, Structural Biology, Protein Engineering, Microbiology
Website:
http://function-structure.org/

31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 He S, Taher NM, Hvorecny KL, Ragusa MJ, Bahl CD, Hickman AB, Dyda F, Madden DR. Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in . Biorxiv : the Preprint Server For Biology. PMID 38293063 DOI: 10.1101/2024.01.16.572601  0.594
2023 Fram B, Truebridge I, Su Y, Riesselman AJ, Ingraham JB, Passera A, Napier E, Thadani NN, Lim S, Roberts K, Kaur G, Stiffler M, Marks DS, Bahl CD, Khan AR, et al. Simultaneous enhancement of multiple functional properties using evolution-informed protein design. Biorxiv : the Preprint Server For Biology. PMID 37214973 DOI: 10.1101/2023.05.09.539914  0.76
2022 Colom MS, Vucinic J, Adolf-Bryfogle J, Bowman JW, Verel S, Moczygemba I, Schiex T, Simoncini D, Bahl CD. Deep Evolutionary Forecasting identifies highly-mutated SARS-CoV-2 variants via functional sequence-landscape enumeration. Research Square. PMID 36482980 DOI: 10.21203/rs.3.rs-2248327/v1  0.778
2022 Garrido JL, Medina MA, Bravo F, McGee S, Fuentes-Villalobos F, Calvo M, Pinos Y, Bowman JW, Bahl CD, Barria MI, Brachman RA, Alvarez RA. IgG targeting distinct seasonal coronavirus- conserved SARS-CoV-2 spike subdomains correlates with differential COVID-19 disease outcomes. Cell Reports. 110904. PMID 35617962 DOI: 10.1016/j.celrep.2022.110904  0.582
2021 Koehler Leman J, Lyskov S, Lewis SM, Adolf-Bryfogle J, Alford RF, Barlow K, Ben-Aharon Z, Farrell D, Fell J, Hansen WA, Harmalkar A, Jeliazkov J, Kuenze G, Krys JD, Ljubetič A, ... ... Bahl CD, et al. Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks. Nature Communications. 12: 6947. PMID 34845212 DOI: 10.1038/s41467-021-27222-7  0.643
2021 Taher NM, Hvorecny KL, Burke CM, Gilman MSA, Heussler GE, Adolf-Bryfogle J, Bahl CD, O'Toole GA, Madden DR. Biochemical and structural characterization of two cif-like epoxide hydrolases from . Current Research in Structural Biology. 3: 72-84. PMID 34235487 DOI: 10.1016/j.crstbi.2021.02.002  0.775
2021 Kennedy AL, Myers KC, Bowman J, Gibson CJ, Camarda ND, Furutani E, Muscato GM, Klein RH, Ballotti K, Liu S, Harris CE, Galvin A, Malsch M, Dale D, Gansner JM, ... ... Bahl C, et al. Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome. Nature Communications. 12: 1334. PMID 33637765 DOI: 10.1038/s41467-021-21588-4  0.585
2020 Adolf-Bryfogle J, Teets FD, Bahl CD. Toward complete rational control over protein structure and function through computational design. Current Opinion in Structural Biology. 66: 170-177. PMID 33276237 DOI: 10.1016/j.sbi.2020.10.015  0.76
2020 Gao M, Mackley IGP, Mesbahi-Vasey S, Bamonte HA, Struyvenberg SA, Landolt L, Pederson NJ, Williams LI, Bahl CD, Brooks L, Amacher JF. Structural Characterization and Computational Analysis of PDZ domains in Monosiga brevicollis. Protein Science : a Publication of the Protein Society. PMID 32914530 DOI: 10.1002/Pro.3947  0.737
2019 Ford AS, Weitzner BD, Bahl CD. Integration of the Rosetta Suite with the Python Software Stack via reproducible packaging and core programming interfaces for distributed simulation. Protein Science : a Publication of the Protein Society. PMID 31495995 DOI: 10.1002/Pro.3721  0.379
2018 Buchko GW, Pulavarti SVSRK, Ovchinnikov V, Shaw EA, Rettie SA, Myler PJ, Karplus M, Szyperski T, Baker D, Bahl CD. Cytosolic expression, solution structures, and molecular dynamics simulation of genetically encodable disulfide-rich de novo designed peptides. Protein Science : a Publication of the Protein Society. PMID 30152054 DOI: 10.1002/Pro.3453  0.465
2018 Lau YK, Baytshtok V, Howard TA, Fiala BM, Morgan JM, Carter LP, Baker D, Lima CD, Bahl CD. Discovery and engineering of enhanced SUMO protease enzymes. The Journal of Biological Chemistry. PMID 29976752 DOI: 10.1074/Jbc.Ra118.004146  0.492
2018 Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen WA, Rupert PB, Brusniak MY, Clarke M, Burke SE, De Van Der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, ... Bahl CD, et al. Screening, large-scale production and structure-based classification of cystine-dense peptides. Nature Structural & Molecular Biology. PMID 29483648 DOI: 10.1038/S41594-018-0033-9  0.337
2018 Buchko G, Bahl C, Baker D. Chemical shifts for the de novo mini protein gHH_44 in the reduced state. Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr27420  0.387
2018 Pulavarti SVSRK, Shaw E, Bahl C, Garry B, Baker D, Szyperski T. Backbone 1H, 13C, and 15N Chemical Shift Assignments for gHEEE_02 in presence of 10 mM TCEP Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr27269  0.317
2017 Hvorecny KL, Dolben E, Moreau-Marquis S, Hampton TH, Shabaneh TB, Flitter BA, Bahl CD, Bomberger JM, Levy BD, Stanton BA, Hogan DA, Madden DR. An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00383.2017. PMID 28982736 DOI: 10.1152/Ajplung.00383.2017  0.6
2017 Chevalier A, Silva DA, Rocklin GJ, Hicks DR, Vergara R, Murapa P, Bernard SM, Zhang L, Lam KH, Yao G, Bahl CD, Miyashita SI, Goreshnik I, Fuller JT, Koday MT, et al. Massively parallel de novo protein design for targeted therapeutics. Nature. PMID 28953867 DOI: 10.1038/Nature23912  0.779
2017 Hvorecny KL, Bahl CD, Kitamura S, Lee KS, Hammock BD, Morisseau C, Madden DR. Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase. Structure (London, England : 1993). PMID 28392259 DOI: 10.1016/J.Str.2017.03.002  0.641
2017 Bahl CD, St Laurent JD, Karthikeyan RS, Priya JL, Prajna L, Zegans ME, Madden DR. The cif Virulence Factor Gene Is Present in Isolates From Patients With Pseudomonas aeruginosa Keratitis. Cornea. PMID 28079684 DOI: 10.1097/Ico.0000000000001132  0.57
2016 Flitter BA, Hvorecny KL, Ono E, Eddens T, Yang J, Kwak DH, Bahl CD, Hampton TH, Morisseau C, Hammock BD, Liu X, Lee JS, Kolls JK, Levy BD, Madden DR, et al. Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators. Proceedings of the National Academy of Sciences of the United States of America. PMID 27980032 DOI: 10.1073/Pnas.1610242114  0.601
2016 Bhardwaj G, Mulligan VK, Bahl CD, Gilmore JM, Harvey PJ, Cheneval O, Buchko GW, Pulavarti SV, Kaas Q, Eletsky A, Huang PS, Johnsen WA, Greisen PJ, Rocklin GJ, Song Y, et al. Accurate de novo design of hyperstable constrained peptides. Nature. PMID 27626386 DOI: 10.1038/Nature19791  0.753
2016 Rödström KE, Regenthal P, Bahl C, Ford A, Baker D, Lindkvist-Petersson K. Two common structural motifs for TCR recognition by staphylococcal enterotoxins. Scientific Reports. 6: 25796. PMID 27180909 DOI: 10.1038/Srep25796  0.432
2016 Bahl CD, Hvorecny KL, Morisseau C, Gerber SA, Madden DR. Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif. Biochemistry. 55: 788-97. PMID 26752215 DOI: 10.1021/Acs.Biochem.5B01229  0.624
2016 Szyperski T, Pulavarti S, Shaw E, Bahl C, Garry B, Baker D. Solution structure of the de novo mini protein gHEEE_02 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr30312  0.406
2015 Bahl CD, Hvorecny KL, Bomberger JM, Stanton BA, Hammock BD, Morisseau C, Madden DR. Inhibiting an epoxide hydrolase virulence factor from Pseudomonas aeruginosa protects CFTR. Angewandte Chemie (International Ed. in English). PMID 26136396 DOI: 10.1002/Anie.201503983  0.63
2014 Bahl CD, Hvorecny KL, Bridges AA, Ballok AE, Bomberger JM, Cady KC, O'Toole GA, Madden DR. Signature motifs identify an Acinetobacter Cif virulence factor with epoxide hydrolase activity. The Journal of Biological Chemistry. 289: 7460-9. PMID 24474692 DOI: 10.1074/Jbc.M113.518092  0.652
2013 Amacher JF, Cushing PR, Bahl CD, Beck T, Madden DR. Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop. The Journal of Biological Chemistry. 288: 5114-26. PMID 23243314 DOI: 10.1074/Jbc.M112.401588  0.739
2012 Ballok AE, Bahl CD, Dolben EL, Lindsay AK, St Laurent JD, Hogan DA, Madden DR, O'Toole GA. Epoxide-mediated CifR repression of cif gene expression utilizes two binding sites in Pseudomonas aeruginosa. Journal of Bacteriology. 194: 5315-24. PMID 22843844 DOI: 10.1128/Jb.00984-12  0.614
2012 Bahl CD, Madden DR. Pseudomonas aeruginosa Cif defines a distinct class of α/β epoxide hydrolases utilizing a His/Tyr ring-opening pair. Protein and Peptide Letters. 19: 186-93. PMID 21933119 DOI: 10.2174/092986612799080392  0.652
2010 Bahl CD, Morisseau C, Bomberger JM, Stanton BA, Hammock BD, O'Toole GA, Madden DR. Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. Journal of Bacteriology. 192: 1785-95. PMID 20118260 DOI: 10.1128/Jb.01348-09  0.654
2010 Bahl CD, MacEachran DP, O'Toole GA, Madden DR. Purification, crystallization and preliminary X-ray diffraction analysis of Cif, a virulence factor secreted by Pseudomonas aeruginosa. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 26-8. PMID 20057063 DOI: 10.1107/S1744309109047599  0.621
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