| Year |
Citation |
Score |
| 2021 |
Laliotis GI, Kenney AD, Chavdoula E, Orlacchio A, Kaba A, La Ferlita A, Anastas V, Tsatsanis C, Beane JD, Sehgal L, Coppola V, Yount JS, Tsichlis PN. Phosphor-IWS1-dependent U2AF2 splicing regulates trafficking of CAR-E-positive intronless gene mRNAs and sensitivity to viral infection. Communications Biology. 4: 1179. PMID 34635782 DOI: 10.1038/s42003-021-02668-z |
0.32 |
|
| 2021 |
Laliotis GI, Chavdoula E, Paraskevopoulou MD, Kaba A, La Ferlita A, Singh S, Anastas V, Nair KA, Orlacchio A, Taraslia V, Vlachos I, Capece M, Hatzigeorgiou A, Palmieri D, Tsatsanis C, ... ... Tsichlis PN, et al. AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing. Nature Communications. 12: 4624. PMID 34330897 DOI: 10.1038/s41467-021-24795-1 |
0.327 |
|
| 2020 |
Polytarchou C, Hatziapostolou M, Yau TO, Christodoulou N, Hinds PW, Kottakis F, Sanidas I, Tsichlis PN. Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47. Proceedings of the National Academy of Sciences of the United States of America. PMID 33139577 DOI: 10.1073/pnas.2017830117 |
0.31 |
|
| 2020 |
Deiktakis EE, Abrams M, Tsapara A, Stournaras C, Tsatsanis C, Tsichlis PN, Kampranis SC. Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells. The Protein Journal. PMID 32270414 DOI: 10.1007/S10930-020-09895-Z |
0.324 |
|
| 2018 |
Orlacchio A, Stark AE, Foray C, Amari F, Sheetz T, Reese E, Tessari A, La Perle K, Palmieri D, Tsichlis PN, Coppola V. Genetic ablation of interacting with Spt6 (Iws1) causes early embryonic lethality. Plos One. 13: e0201030. PMID 30208029 DOI: 10.1371/Journal.Pone.0201030 |
0.318 |
|
| 2018 |
Zacharopoulou N, Tsapara A, Kallergi G, Schmid E, Alkahtani S, Alarifi S, Tsichlis PN, Kampranis SC, Stournaras C. The Epigenetic Factor KDM2B Regulates EMT and Small GTPases in Colon Tumor Cells. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 47: 368-377. PMID 29772566 DOI: 10.1159/000489917 |
0.365 |
|
| 2018 |
Zacharopoulou N, Tsapara A, Kallergi G, Schmid E, Tsichlis PN, Kampranis SC, Stournaras C. The epigenetic factor KDM2B regulates cell adhesion, small rho GTPases, actin cytoskeleton and migration in prostate cancer cells. Biochimica Et Biophysica Acta. 1865: 587-597. PMID 29408056 DOI: 10.1016/J.Bbamcr.2018.01.009 |
0.394 |
|
| 2018 |
Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli M, Sánchez-Rivera F, Park Y, Liang X, Eng G, Taylor MS, Azimi R, ... ... Tsichlis PN, et al. Abstract B38: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis Cancer Research. 78. DOI: 10.1158/1538-7445.Mousemodels17-B38 |
0.304 |
|
| 2018 |
McRee SK, Pietruska JR, Tsichlis PN, Hinds PW. Abstract 1112: AKT2 loss impairs BRAF mutant melanoma metastasis Cancer Research. 78: 1112-1112. DOI: 10.1158/1538-7445.Am2018-1112 |
0.371 |
|
| 2017 |
Peterson JN, Lin B, Shin J, Phelan PJ, Tsichlis P, Schwob JE, Bullock PA. THE REPLICATION OF JCV DNA IN THE G144 OLIGODENDROCYTE CELL LINE IS DEPENDENT UPON AKT. Journal of Virology. PMID 28768870 DOI: 10.1128/Jvi.00735-17 |
0.358 |
|
| 2017 |
Paraskevopoulou MD, Tsichlis PN. A perspective on AKT 25-plus years after its discovery. Science Signaling. 10. PMID 28676491 DOI: 10.1126/Scisignal.Aan8791 |
0.356 |
|
| 2017 |
McNiel EA, Tsichlis PN. Analyses of publicly available genomics resources define FGF-2-expressing bladder carcinomas as EMT-prone, proliferative tumors with low mutation rates and high expression of CTLA-4, PD-1 and PD-L1. Signal Transduction and Targeted Therapy. 2. PMID 28515962 DOI: 10.1038/Sigtrans.2016.45 |
0.344 |
|
| 2017 |
Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera F, Park YK, Liang X, Eng G, Taylor MS, Azimi R, ... ... Tsichlis PN, et al. In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nature Biotechnology. PMID 28459449 DOI: 10.1038/Nbt.3836 |
0.306 |
|
| 2016 |
Voulgarelis M, Tsichlis PN. Proline hydroxylation linked to Akt activation. Science (New York, N.Y.). 353: 870-1. PMID 27563086 DOI: 10.1126/Science.Aah6254 |
0.332 |
|
| 2016 |
Vyrla D, Nikolaidis G, Oakley F, Perugorria MJ, Tsichlis PN, Mann DA, Eliopoulos AG. TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury. Journal of Immunology (Baltimore, Md. : 1950). PMID 27053764 DOI: 10.4049/Jimmunol.1501609 |
0.37 |
|
| 2015 |
Richardson ET, Shukla S, Sweet DR, Wearsch PA, Tsichlis PN, Boom WH, Harding CV. Toll-like receptor 2-dependent extracellular signal-regulated kinase signaling in Mycobacterium tuberculosis-infected macrophages drives anti-inflammatory responses and inhibits Th1 polarization of responding T cells. Infection and Immunity. 83: 2242-54. PMID 25776754 DOI: 10.1128/Iai.00135-15 |
0.343 |
|
| 2015 |
Kanellis DC, Bursac S, Tsichlis PN, Volarevic S, Eliopoulos AG. Physical and functional interaction of the TPL2 kinase with nucleophosmin Oncogene. 34: 2516-2526. PMID 24998852 DOI: 10.1038/Onc.2014.183 |
0.402 |
|
| 2015 |
Foltopoulou P, Pfau R, Betancur-Boissel M, AbdelMageed M, Tsichlis PN, McNiel EA. Abstract 3635: Histone demethylase NDY1/KDM2B as a driver of survival and proliferation of normal and neoplastic mast cells Cancer Research. 75: 3635-3635. DOI: 10.1158/1538-7445.Am2015-3635 |
0.404 |
|
| 2014 |
Kottakis F, Foltopoulou P, Sanidas I, Keller P, Wronski A, Dake BT, Ezell SA, Shen Z, Naber SP, Hinds PW, McNiel E, Kuperwasser C, Tsichlis PN. NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells. Cancer Research. 74: 3935-46. PMID 24853546 DOI: 10.1158/0008-5472.Can-13-2733 |
0.757 |
|
| 2014 |
Sourvinos G, Morou A, Sanidas I, Codruta I, Ezell SA, Doxaki C, Kampranis SC, Kottakis F, Tsichlis PN. The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection. Plos Pathogens. 10: e1004136. PMID 24830456 DOI: 10.1371/Journal.Ppat.1004136 |
0.758 |
|
| 2014 |
Sriskantharajah S, Gückel E, Tsakiri N, Kierdorf K, Brender C, Ben-Addi A, Veldhoen M, Tsichlis PN, Stockinger B, O'Garra A, Prinz M, Kollias G, Ley SC. Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase. Journal of Immunology (Baltimore, Md. : 1950). 192: 3518-29. PMID 24639351 DOI: 10.4049/Jimmunol.1300172 |
0.374 |
|
| 2014 |
Roper J, Sinnamon MJ, Coffee EM, Belmont P, Keung L, Georgeon-Richard L, Wang WV, Faber AC, Yun J, Yilmaz ÖH, Bronson RT, Martin ES, Tsichlis PN, Hung KE. Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. Cancer Letters. 347: 204-11. PMID 24576621 DOI: 10.1016/J.Canlet.2014.02.018 |
0.354 |
|
| 2014 |
Schmidt JW, Wehde BL, Sakamoto K, Triplett AA, Anderson SM, Tsichlis PN, Leone G, Wagner KU. Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Molecular and Cellular Biology. 34: 1363-77. PMID 24469394 DOI: 10.1128/Mcb.01220-13 |
0.451 |
|
| 2014 |
Sanidas I, Polytarchou C, Hatziapostolou M, Ezell SA, Kottakis F, Hu L, Guo A, Xie J, Comb MJ, Iliopoulos D, Tsichlis PN. Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer. Molecular Cell. 53: 577-90. PMID 24462114 DOI: 10.1016/J.Molcel.2013.12.018 |
0.771 |
|
| 2014 |
Corum DG, Tsichlis PN, Muise-Helmericks RC. AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 395-407. PMID 24081905 DOI: 10.1096/Fj.13-235382 |
0.343 |
|
| 2014 |
Sourvinos G, Morou A, Sanidas I, Codruta I, Ezell SA, Doxaki C, Kampranis SC, Kottakis F, Tsichlis PN. NDY1/KDM2B, EZH2 and JARID2 are selectively required for the infection of human foreskin fibroblasts with HCMV whereas the H3K27me3 demethylase JMJD3 inhibits viral infection. Plos Pathogens. DOI: 10.1371/Journal.Ppat.1004136.G001 |
0.736 |
|
| 2014 |
Sanidas I, Polytarchou C, Hatziapostolou M, Ezell SA, Kottakis F, Hu L, Guo A, Xie J, Comb MJ, Iliopoulos D, Tsichlis PN. Abstract 4777: A phosphoproteomics analysis reveals Akt isoform-specific signals that link RNA splicing to non-small cell lung cancer Cancer Research. 74: 4777-4777. DOI: 10.1158/1538-7445.Am2014-4777 |
0.787 |
|
| 2014 |
Foltopoulou P, Betancur-Boissel M, Boissel L, AbdelMageed MA, Tsichlis PN, McNiel EA. Abstract 2046: EZH2 inhibition targets a stem cell population in a canine urothelial carcinoma model Cancer Research. 74: 2046-2046. DOI: 10.1158/1538-7445.Am2014-2046 |
0.356 |
|
| 2013 |
Kyrmizi I, Ioannou M, Hatziapostolou M, Tsichlis PN, Boumpas DT, Tassiulas I. Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice. Journal of Leukocyte Biology. 94: 751-7. PMID 23898046 DOI: 10.1189/Jlb.0113039 |
0.354 |
|
| 2013 |
McNab FW, Ewbank J, Rajsbaum R, Stavropoulos E, Martirosyan A, Redford PS, Wu X, Graham CM, Saraiva M, Tsichlis P, Chaussabel D, Ley SC, O'Garra A. TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production. Journal of Immunology (Baltimore, Md. : 1950). 191: 1732-43. PMID 23842752 DOI: 10.4049/Jimmunol.1300146 |
0.321 |
|
| 2013 |
Luo C, Sheng J, Hu MG, Haluska FG, Cui R, Xu Z, Tsichlis PN, Hu GF, Hinds PW. Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC. Cancer Research. 73: 4337-48. PMID 23650282 DOI: 10.1158/0008-5472.Can-12-4454 |
0.316 |
|
| 2013 |
Gkirtzimanaki K, Gkouskou KK, Oleksiewicz U, Nikolaidis G, Vyrla D, Liontos M, Pelekanou V, Kanellis DC, Evangelou K, Stathopoulos EN, Field JK, Tsichlis PN, Gorgoulis V, Liloglou T, Eliopoulos AG. TPL2 kinase is a suppressor of lung carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: E1470-9. PMID 23533274 DOI: 10.1073/Pnas.1215938110 |
0.377 |
|
| 2013 |
Foltopoulou P, Betancur-Boissel M, Tsichlis PN, McNiel EA. Abstract B52: Targeting epigenetic dysregulation in a canine model of bladder cancer Cancer Research. 73. DOI: 10.1158/1538-7445.Cec13-B52 |
0.388 |
|
| 2012 |
Ezell SA, Tsichlis PN. Akt1, EMSY, BRCA2 and type I IFN signaling: a novel arm of the IFN response. Transcription. 3: 305-9. PMID 23117821 DOI: 10.4161/trns.21904 |
0.757 |
|
| 2012 |
Arranz A, Doxaki C, Vergadi E, Martinez de la Torre Y, Vaporidi K, Lagoudaki ED, Ieronymaki E, Androulidaki A, Venihaki M, Margioris AN, Stathopoulos EN, Tsichlis PN, Tsatsanis C. Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proceedings of the National Academy of Sciences of the United States of America. 109: 9517-22. PMID 22647600 DOI: 10.1073/Pnas.1119038109 |
0.347 |
|
| 2012 |
Serebrennikova OB, Tsatsanis C, Mao C, Gounaris E, Ren W, Siracusa LD, Eliopoulos AG, Khazaie K, Tsichlis PN. Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation. Proceedings of the National Academy of Sciences of the United States of America. 109: E1082-91. PMID 22451924 DOI: 10.1073/Pnas.1115098109 |
0.324 |
|
| 2012 |
Ezell SA, Polytarchou C, Hatziapostolou M, Guo A, Sanidas I, Bihani T, Comb MJ, Sourvinos G, Tsichlis PN. The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY. Proceedings of the National Academy of Sciences of the United States of America. 109: E613-21. PMID 22315412 DOI: 10.1073/Pnas.1115029109 |
0.794 |
|
| 2011 |
Hatziapostolou M, Koukos G, Polytarchou C, Kottakis F, Serebrennikova O, Kuliopulos A, Tsichlis PN. Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration. Science Signaling. 4: ra55. PMID 21868363 DOI: 10.1126/Scisignal.2002006 |
0.399 |
|
| 2011 |
Kottakis F, Polytarchou C, Foltopoulou P, Sanidas I, Kampranis SC, Tsichlis PN. FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway. Molecular Cell. 43: 285-98. PMID 21777817 DOI: 10.1016/J.Molcel.2011.06.020 |
0.307 |
|
| 2011 |
Polytarchou C, Iliopoulos D, Hatziapostolou M, Kottakis F, Maroulakou I, Struhl K, Tsichlis PN. Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation. Cancer Research. 71: 4720-31. PMID 21555366 DOI: 10.1158/0008-5472.Can-11-0365 |
0.346 |
|
| 2011 |
Kottakis F, Polytarchou C, Kampranis S, Tsichlis PN. Abstract 108: FGF-2 regulates cell proliferation, migration and angiogenesis through a novel NDY1/KDM2B-miR101-EZH2 pathway Cancer Research. 71: 108-108. DOI: 10.1158/1538-7445.Am2011-108 |
0.327 |
|
| 2010 |
Iliopoulos D, Lindahl-Allen M, Polytarchou C, Hirsch HA, Tsichlis PN, Struhl K. Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Molecular Cell. 39: 761-72. PMID 20832727 DOI: 10.1016/J.Molcel.2010.08.013 |
0.301 |
|
| 2010 |
Stankovic S, Gugasyan R, Kyparissoudis K, Grumont R, Banerjee A, Tsichlis P, Gerondakis S, Godfrey DI. Distinct roles in NKT cell maturation and function for the different transcription factors in the classical NF-κB pathway. Immunology and Cell Biology. 89: 294-303. PMID 20697425 DOI: 10.1038/Icb.2010.93 |
0.346 |
|
| 2010 |
Hirsch HA, Iliopoulos D, Joshi A, Zhang Y, Jaeger SA, Bulyk M, Tsichlis PN, Shirley Liu X, Struhl K. A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell. 17: 348-61. PMID 20385360 DOI: 10.1016/J.Ccr.2010.01.022 |
0.33 |
|
| 2010 |
Watford WT, Wang CC, Tsatsanis C, Mielke LA, Eliopoulos AG, Daskalakis C, Charles N, Odom S, Rivera J, O'Shea J, Tsichlis PN. Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice. Journal of Immunology (Baltimore, Md. : 1950). 184: 105-13. PMID 19955521 DOI: 10.4049/Jimmunol.0803730 |
0.335 |
|
| 2009 |
Mielke LA, Elkins KL, Wei L, Starr R, Tsichlis PN, O'Shea JJ, Watford WT. Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production. Journal of Immunology (Baltimore, Md. : 1950). 183: 7984-93. PMID 19933865 DOI: 10.4049/Jimmunol.0901336 |
0.344 |
|
| 2009 |
Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou IG, Struhl K, Tsichlis PN. MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Science Signaling. 2: ra62. PMID 19825827 DOI: 10.1126/Scisignal.2000356 |
0.382 |
|
| 2009 |
Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Research. 69: 7507-11. PMID 19752085 DOI: 10.1158/0008-5472.Can-09-2994 |
0.304 |
|
| 2009 |
Androulidaki A, Iliopoulos D, Arranz A, Doxaki C, Schworer S, Zacharioudaki V, Margioris AN, Tsichlis PN, Tsatsanis C. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity. 31: 220-31. PMID 19699171 DOI: 10.1016/J.Immuni.2009.06.024 |
0.306 |
|
| 2009 |
Kaiser F, Cook D, Papoutsopoulou S, Rajsbaum R, Wu X, Yang HT, Grant S, Ricciardi-Castagnoli P, Tsichlis PN, Ley SC, O'Garra A. TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells. The Journal of Experimental Medicine. 206: 1863-71. PMID 19667062 DOI: 10.1084/Jem.20091059 |
0.319 |
|
| 2009 |
Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN. Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus. Proceedings of the National Academy of Sciences of the United States of America. 106: 2641-6. PMID 19202064 DOI: 10.1073/Pnas.0813139106 |
0.345 |
|
| 2009 |
Hu MG, Deshpande A, Enos M, Mao D, Hinds EA, Hu GF, Chang R, Guo Z, Dose M, Mao C, Tsichlis PN, Gounari F, Hinds PW. A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis. Cancer Research. 69: 810-8. PMID 19155308 DOI: 10.1158/0008-5472.Can-08-2473 |
0.421 |
|
| 2008 |
Watford WT, Hissong BD, Durant LR, Yamane H, Muul LM, Kanno Y, Tato CM, Ramos HL, Berger AE, Mielke L, Pesu M, Solomon B, Frucht DM, Paul WE, Sher A, ... ... Tsichlis PN, et al. Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii. The Journal of Experimental Medicine. 205: 2803-12. PMID 19001140 DOI: 10.1084/Jem.20081461 |
0.388 |
|
| 2008 |
Polytarchou C, Pfau R, Hatziapostolou M, Tsichlis PN. The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress. Molecular and Cellular Biology. 28: 7451-64. PMID 18838535 DOI: 10.1128/Mcb.00688-08 |
0.357 |
|
| 2008 |
Maroulakou IG, Oemler W, Naber SP, Klebba I, Kuperwasser C, Tsichlis PN. Distinct roles of the three Akt isoforms in lactogenic differentiation and involution. Journal of Cellular Physiology. 217: 468-77. PMID 18561256 DOI: 10.1002/Jcp.21518 |
0.374 |
|
| 2008 |
Wright GL, Maroulakou IG, Eldridge J, Liby TL, Sridharan V, Tsichlis PN, Muise-Helmericks RC. VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3264-75. PMID 18524868 DOI: 10.1096/Fj.08-106468 |
0.309 |
|
| 2008 |
Hatziapostolou M, Polytarchou C, Panutsopulos D, Covic L, Tsichlis PN. Proteinase-activated receptor-1-triggered activation of tumor progression locus-2 promotes actin cytoskeleton reorganization and cell migration. Cancer Research. 68: 1851-61. PMID 18339866 DOI: 10.1158/0008-5472.Can-07-5793 |
0.42 |
|
| 2008 |
Tsatsanis C, Vaporidi K, Zacharioudaki V, Androulidaki A, Sykulev Y, Margioris AN, Tsichlis PN. Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 2987-92. PMID 18287049 DOI: 10.1073/Pnas.0708381104 |
0.364 |
|
| 2008 |
Pfau R, Tzatsos A, Kampranis SC, Serebrennikova OB, Bear SE, Tsichlis PN. Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. Proceedings of the National Academy of Sciences of the United States of America. 105: 1907-12. PMID 18250326 DOI: 10.1073/Pnas.0711865105 |
0.367 |
|
| 2007 |
Odat O, Matta S, Khalil H, Kampranis SC, Pfau R, Tsichlis PN, Makris AM. Old yellow enzymes, highly homologous FMN oxidoreductases with modulating roles in oxidative stress and programmed cell death in yeast. The Journal of Biological Chemistry. 282: 36010-23. PMID 17897954 DOI: 10.1074/Jbc.M704058200 |
0.312 |
|
| 2007 |
Robinson MJ, Beinke S, Kouroumalis A, Tsichlis PN, Ley SC. Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages. Molecular and Cellular Biology. 27: 7355-64. PMID 17709378 DOI: 10.1128/Mcb.00301-07 |
0.372 |
|
| 2007 |
Van Acker GJ, Perides G, Weiss ER, Das S, Tsichlis PN, Steer ML. Tumor progression locus-2 is a critical regulator of pancreatic and lung inflammation during acute pancreatitis. The Journal of Biological Chemistry. 282: 22140-9. PMID 17537724 DOI: 10.1074/Jbc.M702225200 |
0.312 |
|
| 2007 |
Black TM, Andrews CL, Kilili G, Ivan M, Tsichlis PN, Vouros P. Characterization of phosphorylation sites on Tpl2 using IMAC enrichment and a linear ion trap mass spectrometer. Journal of Proteome Research. 6: 2269-76. PMID 17472361 DOI: 10.1021/Pr0700293 |
0.35 |
|
| 2007 |
Tzatsos A, Tsichlis PN. Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794. The Journal of Biological Chemistry. 282: 18069-82. PMID 17459875 DOI: 10.1074/Jbc.M610101200 |
0.4 |
|
| 2007 |
Mao C, Tili EG, Dose M, Haks MC, Bear SE, Maroulakou I, Horie K, Gaitanaris GA, Fidanza V, Ludwig T, Wiest DL, Gounari F, Tsichlis PN. Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition. Journal of Immunology (Baltimore, Md. : 1950). 178: 5443-53. PMID 17442925 DOI: 10.4049/Jimmunol.178.9.5443 |
0.392 |
|
| 2007 |
Tsichlis PN, Hatziapostolou M, Hinds PW. Timing is everything: regulation of Cdk1 and aneuploidy. Developmental Cell. 12: 477-9. PMID 17419986 DOI: 10.1016/J.Devcel.2007.03.010 |
0.361 |
|
| 2007 |
Maroulakou IG, Oemler W, Naber SP, Tsichlis PN. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Research. 67: 167-77. PMID 17210696 DOI: 10.1158/0008-5472.Can-06-3782 |
0.412 |
|
| 2007 |
Pfau R, Tzatsos A, Bear SE, Polytarchou C, Kampranis S, Van Etten RA, Tsichlis PN. A Chromatin-Associated Histone H3 Dementhylase Promotes the Immortalization of MEFs and the Cycling of HSC-Like Cells in Culture. Blood. 110: 96-96. DOI: 10.1182/Blood.V110.11.96.96 |
0.385 |
|
| 2006 |
Tomczak MF, Gadjeva M, Wang YY, Brown K, Maroulakou I, Tsichlis PN, Erdman SE, Fox JG, Horwitz BH. Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus. Journal of Immunology (Baltimore, Md. : 1950). 176: 1244-51. PMID 16394015 DOI: 10.4049/Jimmunol.176.2.1244 |
0.304 |
|
| 2006 |
Shao Z, Bhattacharya K, Hsich E, Park L, Walters B, Germann U, Wang YM, Kyriakis J, Mohanlal R, Kuida K, Namchuk M, Salituro F, Yao YM, Hou WM, Chen X, ... ... Tsichlis PN, et al. c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo. Circulation Research. 98: 111-8. PMID 16306447 DOI: 10.1161/01.Res.0000197781.20524.B9 |
0.405 |
|
| 2006 |
Eliopoulos AG, Das S, Tsichlis PN. The tyrosine kinase Syk regulates TPL2 activation signals. The Journal of Biological Chemistry. 281: 1371-80. PMID 16291755 DOI: 10.1074/Jbc.M506790200 |
0.377 |
|
| 2005 |
Du K, Tsichlis PN. Regulation of the Akt kinase by interacting proteins. Oncogene. 24: 7401-9. PMID 16288287 DOI: 10.1038/Sj.Onc.1209099 |
0.39 |
|
| 2005 |
Testa JR, Tsichlis PN. AKT signaling in normal and malignant cells. Oncogene. 24: 7391-3. PMID 16288285 DOI: 10.1038/Sj.Onc.1209100 |
0.415 |
|
| 2005 |
Vaporidi K, Tsatsanis C, Georgopoulos D, Tsichlis PN. Effects of hypoxia and hypercapnia on surfactant protein expression proliferation and apoptosis in A549 alveolar epithelial cells. Life Sciences. 78: 284-93. PMID 16125734 DOI: 10.1016/J.Lfs.2005.04.070 |
0.308 |
|
| 2005 |
Cho J, Melnick M, Solidakis GP, Tsichlis PN. Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals. The Journal of Biological Chemistry. 280: 20442-8. PMID 15778223 DOI: 10.1074/Jbc.M413554200 |
0.416 |
|
| 2005 |
Cho J, Tsichlis PN. Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide. Proceedings of the National Academy of Sciences of the United States of America. 102: 2350-5. PMID 15699325 DOI: 10.1073/Pnas.0409856102 |
0.347 |
|
| 2004 |
Bieganowski P, Shilinski K, Tsichlis PN, Brenner C. Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance. The Journal of Biological Chemistry. 279: 44656-66. PMID 15319434 DOI: 10.1074/Jbc.M406151200 |
0.366 |
|
| 2004 |
Doan LL, Porter SD, Duan Z, Flubacher MM, Montoya D, Tsichlis PN, Horwitz M, Gilks CB, Grimes HL. Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells. Nucleic Acids Research. 32: 2508-19. PMID 15131254 DOI: 10.1093/Nar/Gkh570 |
0.395 |
|
| 2003 |
Eliopoulos AG, Wang CC, Dumitru CD, Tsichlis PN. Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40. The Embo Journal. 22: 3855-64. PMID 12881420 DOI: 10.1093/Emboj/Cdg386 |
0.327 |
|
| 2003 |
Hoyal CR, Gutierrez A, Young BM, Catz SD, Lin JH, Tsichlis PN, Babior BM. Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase. Proceedings of the National Academy of Sciences of the United States of America. 100: 5130-5. PMID 12704229 DOI: 10.1073/Pnas.1031526100 |
0.389 |
|
| 2003 |
Doan LL, Kitay MK, Yu Q, Singer A, Herblot S, Hoang T, Bear SE, Morse HC, Tsichlis PN, Grimes HL. Growth factor independence-1B expression leads to defects in T cell activation, IL-7 receptor alpha expression, and T cell lineage commitment. Journal of Immunology (Baltimore, Md. : 1950). 170: 2356-66. PMID 12594258 DOI: 10.4049/Jimmunol.170.5.2356 |
0.353 |
|
| 2002 |
Kontoyiannis D, Boulougouris G, Manoloukos M, Armaka M, Apostolaki M, Pizarro T, Kotlyarov A, Forster I, Flavell R, Gaestel M, Tsichlis P, Cominelli F, Kollias G. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. The Journal of Experimental Medicine. 196: 1563-74. PMID 12486099 DOI: 10.1084/Jem.20020281 |
0.355 |
|
| 2002 |
Condorelli G, Morisco C, Latronico MV, Claudio PP, Dent P, Tsichlis P, Condorelli G, Frati G, Drusco A, Croce CM, Napoli C. TNF-alpha signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF-alpha receptor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1732-7. PMID 12409315 DOI: 10.1096/Fj.02-0419Com |
0.347 |
|
| 2002 |
Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, Vinci F, Chiappetta G, Tsichlis P, Bellacosa A, Fusco A, Santoro M. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nature Medicine. 8: 1136-44. PMID 12244303 DOI: 10.1038/Nm762 |
0.431 |
|
| 2002 |
Eliopoulos AG, Dumitru CD, Wang CC, Cho J, Tsichlis PN. Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals. The Embo Journal. 21: 4831-40. PMID 12234923 DOI: 10.1093/Emboj/Cdf478 |
0.352 |
|
| 2002 |
Das S, Lin JH, Papamatheakis J, Sykulev Y, Tsichlis PN. Differential splicing generates Tvl-1/RFXANK isoforms with different functions. The Journal of Biological Chemistry. 277: 45172-80. PMID 12215433 DOI: 10.1074/Jbc.M204117200 |
0.334 |
|
| 2002 |
Basso AD, Solit DB, Chiosis G, Giri B, Tsichlis P, Rosen N. Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. The Journal of Biological Chemistry. 277: 39858-66. PMID 12176997 DOI: 10.1074/Jbc.M206322200 |
0.394 |
|
| 2002 |
Chan TO, Rodeck U, Chan AM, Kimmelman AC, Rittenhouse SE, Panayotou G, Tsichlis PN. Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit. Cancer Cell. 1: 181-91. PMID 12086876 DOI: 10.1016/S1535-6108(02)00033-8 |
0.36 |
|
| 2002 |
Zhu J, Guo L, Min B, Watson CJ, Hu-Li J, Young HA, Tsichlis PN, Paul WE. Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. Immunity. 16: 733-44. PMID 12049724 DOI: 10.1016/S1074-7613(02)00317-5 |
0.333 |
|
| 2002 |
Eliopoulos AG, Davies C, Blake SS, Murray P, Najafipour S, Tsichlis PN, Young LS. The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2. Journal of Virology. 76: 4567-79. PMID 11932422 DOI: 10.1128/Jvi.76.9.4567-4579.2002 |
0.415 |
|
| 2001 |
Chan TO, Tsichlis PN. PDK2: a complex tail in one Akt Science"S Stke [Electronic Resource] : Signal Transduction Knowledge Environment. 2001. PMID 11752635 DOI: 10.1126/Stke.2001.66.Pe1 |
0.365 |
|
| 2001 |
Malstrom S, Tili E, Kappes D, Ceci JD, Tsichlis PN. Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus Proceedings of the National Academy of Sciences of the United States of America. 98: 14967-14972. PMID 11752445 DOI: 10.1073/Pnas.231467698 |
0.353 |
|
| 2001 |
Sun M, Wang G, Paciga JE, Feldman RI, Yuan ZQ, Ma XL, Shelley SA, Jove R, Tsichlis PN, Nicosia SV, Cheng JQ. AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. The American Journal of Pathology. 159: 431-7. PMID 11485901 DOI: 10.1016/S0002-9440(10)61714-2 |
0.427 |
|
| 2001 |
Mende I, Malstrom S, Tsichlis PN, Vogt PK, Aoki M. Oncogenic transformation induced by membrane-targeted Akt2 and Akt3 Oncogene. 20: 4419-4423. PMID 11466625 DOI: 10.1038/Sj.Onc.1204486 |
0.405 |
|
| 2001 |
Lee-Kwon W, Johns DC, Cha B, Cavet M, Park J, Tsichlis P, Donowitz M. Constitutively active phosphatidylinositol 3-kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3. The Journal of Biological Chemistry. 276: 31296-304. PMID 11375999 DOI: 10.1074/Jbc.M103900200 |
0.397 |
|
| 2001 |
Patriotis C, Russeva MG, Lin JH, Srinivasula SM, Markova DZ, Tsatsanis C, Makris A, Alnemri ES, Tsichlis PN. Tpl-2 induces apoptosis by promoting the assembly of protein complexes that contain caspase-9, the adapter protein Tvl-1, and procaspase-3 Journal of Cellular Physiology. 187: 176-187. PMID 11267997 DOI: 10.1002/Jcp.1066 |
0.348 |
|
| 2001 |
Kwon WL, Johns D, Cavet M, Park J, Tsichlis P, Inst K, Un TJ, Donowitz M. Constitutively active phosphatidlyinositol 3-kinase (Pl 3-K) and Akt are sufficient to stimulate NHE3: Insights in mechanisms of NHE3 stimulation Gastroenterology. 120: A696. DOI: 10.1016/S0016-5085(08)83466-X |
0.323 |
|
| 2000 |
De Vita G, Melillo RM, Carlomagno F, Visconti R, Castellone MD, Bellacosa A, Billaud M, Fusco A, Tsichlis PN, Santoro M. Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival. Cancer Research. 60: 3727-31. PMID 10919641 |
0.306 |
|
| 2000 |
Kampranis SC, Damianova R, Atallah M, Toby G, Kondi G, Tsichlis PN, Makris AM. A novel plant glutathione S-transferase/peroxidase suppresses Bax lethality in yeast Journal of Biological Chemistry. 275: 29207-29216. PMID 10859306 DOI: 10.1074/Jbc.M002359200 |
0.323 |
|
| 2000 |
Morisco C, Zebrowski D, Condorelli G, Tsichlis P, Vatner SF, Sadoshima J. The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes. The Journal of Biological Chemistry. 275: 14466-75. PMID 10799529 DOI: 10.1074/Jbc.275.19.14466 |
0.417 |
|
| 1999 |
Chan TO, Rittenhouse SE, Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation Annual Review of Biochemistry. 68: 965-1014. PMID 10872470 DOI: 10.1146/Annurev.Biochem.68.1.965 |
0.381 |
|
| 1999 |
Osada M, Tolkacheva T, Li W, Chan TO, Tsichlis PN, Saez R, Kimmelman AC, Chan AM. Differential roles of Akt, Rac, and Ral in R-Ras-mediated cellular transformation, adhesion, and survival. Molecular and Cellular Biology. 19: 6333-44. PMID 10454580 DOI: 10.1128/Mcb.19.9.6333 |
0.338 |
|
| 1999 |
Srinivasula SM, Ahmadt M, Lin JH, Poyet JL, Fernandes-Alnemri T, Tsichlis PN, Alnemri ES. CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-κB activation and apoptosis Journal of Biological Chemistry. 274: 17946-17954. PMID 10364242 DOI: 10.1074/Jbc.274.25.17946 |
0.344 |
|
| 1999 |
Lin JH, Makris A, McMahon C, Bear SE, Patriotis C, Prasad VR, Brent R, Golemis EA, Tsichlis PN. The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1 Journal of Biological Chemistry. 274: 14706-14715. PMID 10329666 DOI: 10.1074/Jbc.274.21.14706 |
0.406 |
|
| 1999 |
Grammatikakis N, Lin JH, Grammatikakis A, Tsichlis PN, Cochran BH. p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function. Molecular and Cellular Biology. 19: 1661-72. PMID 10022854 DOI: 10.1128/Mcb.19.3.1661 |
0.369 |
|
| 1999 |
Aoki M, Batista O, Bellacosa A, Tsichlis P, Vogt PK. The akt kinase: molecular determinants of oncogenicity. Proceedings of the National Academy of Sciences of the United States of America. 95: 14950-5. PMID 9843996 DOI: 10.1073/Pnas.95.25.14950 |
0.385 |
|
| 1998 |
Tsatsanis C, Patriotic C, Tsichlis PN. Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-κB Oncogene. 17: 2609-2618. PMID 9840924 DOI: 10.1038/Sj.Onc.1202460 |
0.382 |
|
| 1998 |
Muise-Helmericks RC, Grimes HL, Bellacosa A, Malstrom SE, Tsichlis PN, Rosen N. Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway. The Journal of Biological Chemistry. 273: 29864-72. PMID 9792703 DOI: 10.1074/Jbc.273.45.29864 |
0.39 |
|
| 1998 |
Bellacosa A, Chan TO, Ahmed NN, Datta K, Malstrom S, Stokoe D, McCormick F, Feng J, Tsichlis P. Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene. 17: 313-25. PMID 9690513 DOI: 10.1038/Sj.Onc.1201947 |
0.359 |
|
| 1998 |
Tong B, Grimes HL, Yang TY, Bear SE, Qin Z, Du K, El-Deiry WS, Tsichlis PN. The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation. Molecular and Cellular Biology. 18: 2462-73. PMID 9566867 DOI: 10.1128/Mcb.18.5.2462 |
0.354 |
|
| 1998 |
Eves EM, Xiong W, Bellacosa A, Kennedy SG, Tsichlis PN, Rosner MR, Hay N. Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line Molecular and Cellular Biology. 18: 2143-2152. PMID 9528786 DOI: 10.1128/Mcb.18.4.2143 |
0.422 |
|
| 1998 |
Tsatsanis C, Patriotis C, Bear SE, Tsichlis PN. The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines Proceedings of the National Academy of Sciences of the United States of America. 95: 3827-3832. PMID 9520452 DOI: 10.1073/Pnas.95.7.3827 |
0.373 |
|
| 1997 |
Skorski T, Bellacosa A, Nieborowska-Skorska M, Majewski M, Martinez R, Choi JK, Trotta R, Wlodarski P, Perrotti D, Chan TO, Wasik MA, Tsichlis PN, Calabretta B. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway Embo Journal. 16: 6151-6161. PMID 9321394 DOI: 10.1093/Emboj/16.20.6151 |
0.416 |
|
| 1997 |
King WG, Mattaliano MD, Chan TO, Tsichlis PN, Brugge JS. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation. Molecular and Cellular Biology. 17: 4406-18. PMID 9234699 DOI: 10.1128/Mcb.17.8.4406 |
0.386 |
|
| 1997 |
Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A, Tsichlis PN, Cantley LC, Roberts TM, Vogt PK. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase Science. 276: 1848-1850. PMID 9188528 DOI: 10.1126/Science.276.5320.1848 |
0.374 |
|
| 1997 |
Kennedy SG, Wagner AJ, Conzen SD, Jordán J, Bellacosa A, Tsichlis PN, Hay N. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal Genes and Development. 11: 701-713. PMID 9087425 DOI: 10.1101/Gad.11.6.701 |
0.4 |
|
| 1997 |
Ceci JD, Patriotis CP, Tsatsanis C, Makris AM, Kovatch R, Swing DA, Jenkins NA, Tsichlis PN, Copeland NG. Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation Genes and Development. 11: 688-700. PMID 9087424 DOI: 10.1101/Gad.11.6.688 |
0.422 |
|
| 1996 |
Grimes HL, Gilks CB, Chan TO, Porter S, Tsichlis PN. The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death. Proceedings of the National Academy of Sciences of the United States of America. 93: 14569-73. PMID 8962093 DOI: 10.1073/Pnas.93.25.14569 |
0.38 |
|
| 1996 |
Datta K, Bellacosaf A, Chan TO, Tsichlis PN. Akt is a direct target of the phosphatidylinositol 3-kinase: Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells Journal of Biological Chemistry. 271: 30835-30839. PMID 8940066 DOI: 10.1074/Jbc.271.48.30835 |
0.385 |
|
| 1996 |
Grimes HL, Chan TO, Zweidler-McKay PA, Tong B, Tsichlis PN. The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal. Molecular and Cellular Biology. 16: 6263-72. PMID 8887656 DOI: 10.1128/Mcb.16.11.6263 |
0.362 |
|
| 1996 |
Zweidler-Mckay PA, Grimes HL, Flubacher MM, Tsichlis PN. Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor. Molecular and Cellular Biology. 16: 4024-34. PMID 8754800 DOI: 10.1128/Mcb.16.8.4024 |
0.339 |
|
| 1995 |
Gilks CB, Porter SD, Barker C, Tsichlis PN, Gout PW. Prolactin (PRL)-dependent expression of a zinc finger protein-encoding gene, Gfi-1, in Nb2 lymphoma cells: Constitutive expression in autonomous sublines Endocrinology. 136: 1805-1808. PMID 7895694 DOI: 10.1210/Endo.136.4.7895694 |
0.363 |
|
| 1995 |
Datta K, Franke TF, Chan TO, Makris A, Yang SI, Kaplan DR, Morrison DK, Golemis EA, Tsichlis PN. AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation Molecular and Cellular Biology. 15: 2304-2310. PMID 7891724 DOI: 10.1128/Mcb.15.4.2304 |
0.316 |
|
| 1995 |
Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell. 81: 727-36. PMID 7774014 DOI: 10.1016/0092-8674(95)90534-0 |
0.394 |
|
| 1994 |
Bellacosa A, Datta K, Bear SE, Patriotis C, Lazo PA, Copeland NG, Jenkins NA, Tsichlis PN. Effects of provirus integration in the Tpl-1/Ets-1 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas: Levels of expression, polyadenylation, transcriptional initiation, and differential splicing of the Ets-1 mRNA Journal of Virology. 68: 2320-2330. PMID 8139017 DOI: 10.1128/Jvi.68.4.2320-2330.1994 |
0.347 |
|
| 1994 |
Patriotis C, Tsichlis PN. The activated Mlvi-4 locus in moloney murine leukemia virus-induced rat T- cell lymphomas encodes an Env/Mlvi-4 fusion protein Journal of Virology. 68: 7927-7932. PMID 7966583 DOI: 10.1128/Jvi.68.12.7927-7932.1994 |
0.348 |
|
| 1994 |
Patriotis C, Makris A, Chernoff J, Tsichlis PN. Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase Proceedings of the National Academy of Sciences of the United States of America. 91: 9755-9759. PMID 7937886 DOI: 10.1073/Pnas.91.21.9755 |
0.389 |
|
| 1993 |
Makris A, Patriotis C, Bear SE, Tsichlis PN. Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: Activation by provirus insertion Journal of Virology. 67: 4283-4289. PMID 8510223 DOI: 10.1128/Jvi.67.7.4283-4289.1993 |
0.422 |
|
| 1993 |
Gilks CB, Bear SE, Grimes HL, Tsichlis PN. Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein. Molecular and Cellular Biology. 13: 1759-68. PMID 8441411 DOI: 10.1128/Mcb.13.3.1759 |
0.313 |
|
| 1993 |
Patriotis C, Makris A, Bear SE, Tsichlis PN. Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation Proceedings of the National Academy of Sciences of the United States of America. 90: 2251-2255. PMID 7681591 DOI: 10.1073/Pnas.90.6.2251 |
0.411 |
|
| 1992 |
Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN, Testa JR. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas Proceedings of the National Academy of Sciences of the United States of America. 89: 9267-9271. PMID 1409633 DOI: 10.1073/Pnas.89.19.9267 |
0.378 |
|
| 1992 |
Barker CS, Bear SE, Keler T, Copeland NG, Gilbert DJ, Jenkins NA, Yeung RS, Tsichlis PN. Activation of the prolactin receptor gene by promoter insertion in a moloney murine leukemia virus-induced rat thymoma Journal of Virology. 66: 6763-6768. PMID 1404614 DOI: 10.1128/Jvi.66.11.6763-6768.1992 |
0.305 |
|
| 1991 |
Tsichlis PN, Bear SE. Infection by mink cell focus-forming viruses confers interleukin 2 (IL-2) independence to an IL-2-dependent rat T-cell lymphoma line Proceedings of the National Academy of Sciences of the United States of America. 88: 4611-4615. PMID 2052545 DOI: 10.1073/Pnas.88.11.4611 |
0.318 |
|
| 1991 |
Bellacosa A, Lazo PA, Bear SE, Tsichlis PN. The Rat Leukocyte Antigen MRC OX-44 Is a Member of a New Family of Cell Surface Proteins Which Appear to Be Involved in Growth Regulation Molecular and Cellular Biology. 11: 2864-2872. PMID 2017181 DOI: 10.1128/Mcb.11.5.2864 |
0.341 |
|
| 1991 |
Bellacosa A, Testa JR, Staal SP, Tsichlis PN. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region Science. 254: 274-277. PMID 1833819 DOI: 10.1126/Science.1833819 |
0.378 |
|
| 1991 |
Tsichlis PN, Lazo PA. Virus-host interactions and the pathogenesis of murine and human oncogenic retroviruses Current Topics in Microbiology and Immunology. 171: 96-171. PMID 1667631 DOI: 10.1007/978-3-642-76524-7_5 |
0.303 |
|
| 1990 |
Lazo PA, Klein-Szanto AJP, Tsichlis PN. T-cell lymphoma lines derived from rat thymomas induced by moloney murine leukemia virus: Phenotypic diversity and its implications Journal of Virology. 64: 3948-3959. PMID 2196385 DOI: 10.1128/Jvi.64.8.3948-3959.1990 |
0.353 |
|
| 1990 |
Tsichlis PN, Lee JS, Bear SE, Lazo PA, Patriotis C, Gustafson E, Shinton S, Jenkins NA, Copeland NG, Huebner K, Croce C, Levan G, Hanson C. Activation of multiple genes by provirus integration in the Mlvi-4 locus in T-cell lymphomas induced by moloney murine leukemia virus Journal of Virology. 64: 2236-2244. PMID 1691313 DOI: 10.1128/Jvi.64.5.2236-2244.1990 |
0.364 |
|
| 1990 |
Lazo PA, Lee JS, Tsichlis PN. Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas Proceedings of the National Academy of Sciences of the United States of America. 87: 170-173. PMID 1688653 DOI: 10.1073/Pnas.87.1.170 |
0.338 |
|
| 1989 |
Bellacosa A, Lazo PA, Bear SE, Shinton S, Tsichlis PN. Induction of multiple independent T-cell lymphomas in rats inoculated with Moloney murine leukemia virus Proceedings of the National Academy of Sciences of the United States of America. 86: 4269-4272. PMID 2786211 DOI: 10.1073/Pnas.86.11.4269 |
0.346 |
|
| 1989 |
Tsichlis PN, Shepherd BM, Bear SE. Activation of the Mlvi-1/mis-1/pvt-1 locus in Moloney murine leukemia virus-induced T-cell lymphomas Proceedings of the National Academy of Sciences of the United States of America. 86: 5487-5491. PMID 2748599 DOI: 10.1073/Pnas.86.14.5487 |
0.371 |
|
| 1989 |
Bear SE, Bellacosa A, Lazo PA, Jenkins NA, Copeland NG, Hanson C, Levan G, Tsichlis PN. Provirus insertion in Tpl-1, an Ets-1-related oncogene, is associated with tumor progression in Moloney murine leukemia virus-induced rat thymic lymphomas Proceedings of the National Academy of Sciences of the United States of America. 86: 7495-7499. PMID 2552446 DOI: 10.1073/Pnas.86.19.7495 |
0.326 |
|
| 1986 |
Wirschubsky Z, Tsichlis P, Klein G, Sumegi J. Rearrangement of c-myc, pim-1 and Mlvi-1 and trisomy of chromosome 15 in MCF- and Moloney-MuLV-induced murine T-cell leukemias. International Journal of Cancer. 38: 739-45. PMID 3021636 DOI: 10.1002/Ijc.2910380518 |
0.322 |
|
| 1985 |
Tsichlis PN, Strauss PG, Lohse MA. Concerted DNA rearrangements in Moloney murine leukemia virus-induced thymomas: A potential synergistic relationship in oncogenesis Journal of Virology. 56: 258-267. PMID 2993654 DOI: 10.1128/Jvi.56.1.258-267.1985 |
0.306 |
|
| 1983 |
Tsichlis PN, Strauss PG, Hu LF. A common region for proviral DNA integration in MoMuLV-induced rat thymic lymphomas Nature. 302: 445-449. PMID 6300684 DOI: 10.1038/302445A0 |
0.301 |
|
| 1981 |
Coffin JM, Tsichlis PN, Robinson HL. Genetics of leukemogenesis by avian leukosis viruses Hamatologie Und Bluttransfusion. 26: 432-438. PMID 6274756 DOI: 10.1007/978-3-642-67984-1_79 |
0.307 |
|
| 1980 |
Tsichlis PN, Coffin JM. Recombinants between endogenous and exogenous avian tumor viruses: Role of the C region and other portions of the genome in the control of replication and transformation Journal of Virology. 33: 238-249. PMID 6245229 DOI: 10.1128/Jvi.33.1.238-249.1980 |
0.304 |
|
| 1980 |
Tsichlis PN, Conklin KF, Coffin JM. Mutant and recombinant avian retroviruses with extended host range Proceedings of the National Academy of Sciences of the United States of America. 77: 536-540. PMID 6244565 DOI: 10.1073/Pnas.77.1.536 |
0.305 |
|
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