| Year |
Citation |
Score |
| 2024 |
Ghadirian N, Morgan RD, Horton NC. DNA Sequence Control of Enzyme Filamentation and Activation of the SgrAI Endonuclease. Biochemistry. PMID 38207281 DOI: 10.1021/acs.biochem.3c00313 |
0.521 |
|
| 2022 |
Lyumkis D, Horton NC. The role of filamentation in activation and DNA sequence specificity of the sequence-specific endonuclease SgrAI. Biochemical Society Transactions. 50: 1703-1714. PMID 36398769 DOI: 10.1042/BST20220547 |
0.57 |
|
| 2022 |
Sanchez JL, Ghadirian N, Horton NC. High-Resolution Structure of the Nuclease Domain of the Human Parvovirus B19 Main Replication Protein NS1. Journal of Virology. e0216421. PMID 35435730 DOI: 10.1128/jvi.02164-21 |
0.508 |
|
| 2022 |
Shan Z, Ghadirian N, Lyumkis D, Horton NC. Pretransition state and apo structures of the filament-forming enzyme SgrAI elucidate mechanisms of activation and substrate specificity. The Journal of Biological Chemistry. 298: 101760. PMID 35202658 DOI: 10.1016/j.jbc.2022.101760 |
0.613 |
|
| 2019 |
Park CK, Horton NC. Structures, functions, and mechanisms of filament forming enzymes: a renaissance of enzyme filamentation. Biophysical Reviews. PMID 31734826 DOI: 10.1007/S12551-019-00602-6 |
0.336 |
|
| 2019 |
Polley S, Lyumkis D, Horton NC. Mechanism of Filamentation-Induced Allosteric Activation of the SgrAI Endonuclease. Structure (London, England : 1993). PMID 31447289 DOI: 10.1016/J.Str.2019.08.001 |
0.638 |
|
| 2018 |
Xu P, Ganaie SS, Wang X, Wang Z, Kleiboeker S, Horton NC, Heier RF, Meyers MJ, Tavis JE, Qiu J. Endonuclease Activity Inhibition of the NS1 Protein of Parvovirus B19 as a Novel Target for Antiviral Drug Development. Antimicrobial Agents and Chemotherapy. PMID 30530599 DOI: 10.1128/Aac.01879-18 |
0.523 |
|
| 2018 |
Barahona C, Basantes LE, Tompkins KJ, Heitman DM, Chukwu BI, Sanchez J, Sanchez JL, Ghadirian N, Park CK, Horton NC. The Need for Speed: Run-On Oligomer Filament Formation Provides Maximum Speed with Maximum Sequestration of Activity. Journal of Virology. PMID 30518649 DOI: 10.1128/Jvi.01647-18 |
0.503 |
|
| 2018 |
Park CK, Sanchez JL, Barahona C, Basantes LE, Sanchez J, Hernandez C, Horton NC. The run-on oligomer filament enzyme mechanism of SgrAI. Part 1: Assembly kinetics of the run-on oligomer filament. The Journal of Biological Chemistry. PMID 30068553 DOI: 10.1074/Jbc.Ra118.003680 |
0.582 |
|
| 2018 |
Park CK, Sanchez JL, Barahona C, Basantes LE, Sanchez J, Hernandez C, Horton NC. The run-on oligomer filament enzyme mechanism of SgrAI. Part 2: Kinetic modeling of the full DNA cleavage pathway. The Journal of Biological Chemistry. PMID 30054273 DOI: 10.1074/Jbc.Ra118.003682 |
0.597 |
|
| 2016 |
Sanchez JL, Romero Z, Quinones A, Torgeson KR, Horton NC. DNA Binding and Cleavage by Human Parvovirus B19 NS1 Nuclease Domain. Biochemistry. PMID 27809499 DOI: 10.1021/Acs.Biochem.6B00534 |
0.53 |
|
| 2015 |
Shah S, Sanchez J, Stewart A, Piperakis MM, Cosstick R, Nichols C, Park CK, Ma X, Wysocki V, Bitinaite J, Horton NC. Probing the run-on oligomer of activated SgrAI bound to DNA. Plos One. 10: e0124783. PMID 25880668 DOI: 10.1371/Journal.Pone.0124783 |
0.713 |
|
| 2015 |
Shah S, Dunten P, Stiteler A, Park CK, Horton NC. Structure and specificity of FEN-1 from Methanopyrus kandleri. Proteins. 83: 188-94. PMID 25354467 DOI: 10.1002/Prot.24704 |
0.628 |
|
| 2013 |
Lyumkis D, Talley H, Stewart A, Shah S, Park CK, Tama F, Potter CS, Carragher B, Horton NC. Allosteric regulation of DNA cleavage and sequence-specificity through run-on oligomerization. Structure (London, England : 1993). 21: 1848-58. PMID 24055317 DOI: 10.1016/J.Str.2013.08.012 |
0.723 |
|
| 2013 |
Ma X, Shah S, Zhou M, Park CK, Wysocki VH, Horton NC. Structural analysis of activated SgrAI-DNA oligomers using ion mobility mass spectrometry. Biochemistry. 52: 4373-81. PMID 23742104 DOI: 10.1021/Bi3013214 |
0.711 |
|
| 2011 |
Little EJ, Dunten PW, Bitinaite J, Horton NC. New clues in the allosteric activation of DNA cleavage by SgrAI: structures of SgrAI bound to cleaved primary-site DNA and uncleaved secondary-site DNA. Acta Crystallographica. Section D, Biological Crystallography. 67: 67-74. PMID 21206063 DOI: 10.1107/S0907444910047785 |
0.641 |
|
| 2010 |
Park CK, Joshi HK, Agrawal A, Ghare MI, Little EJ, Dunten PW, Bitinaite J, Horton NC. Domain swapping in allosteric modulation of DNA specificity. Plos Biology. 8: e1000554. PMID 21151881 DOI: 10.1371/Journal.Pbio.1000554 |
0.638 |
|
| 2010 |
Park CK, Stiteler AP, Shah S, Ghare MI, Bitinaite J, Horton NC. Activation of DNA cleavage by oligomerization of DNA-bound SgrAI. Biochemistry. 49: 8818-30. PMID 20836535 DOI: 10.1021/Bi100557V |
0.719 |
|
| 2010 |
Horton NC, Park CK. Crystallization of zinc finger proteins bound to DNA. Methods in Molecular Biology (Clifton, N.J.). 649: 457-77. PMID 20680852 DOI: 10.1007/978-1-60761-753-2_28 |
0.505 |
|
| 2008 |
Little EJ, Babic AC, Horton NC. Early interrogation and recognition of DNA sequence by indirect readout. Structure (London, England : 1993). 16: 1828-37. PMID 19081059 DOI: 10.1016/J.Str.2008.09.009 |
0.567 |
|
| 2008 |
Babic AC, Little EJ, Manohar VM, Bitinaite J, Horton NC. DNA distortion and specificity in a sequence-specific endonuclease. Journal of Molecular Biology. 383: 186-204. PMID 18762194 DOI: 10.1016/J.Jmb.2008.08.032 |
0.619 |
|
| 2008 |
Dunten PW, Little EJ, Gregory MT, Manohar VM, Dalton M, Hough D, Bitinaite J, Horton NC. The structure of SgrAI bound to DNA; recognition of an 8 base pair target. Nucleic Acids Research. 36: 5405-16. PMID 18701646 DOI: 10.1093/Nar/Gkn510 |
0.658 |
|
| 2006 |
Segal DJ, Crotty JW, Bhakta MS, Barbas CF, Horton NC. Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA. Journal of Molecular Biology. 363: 405-21. PMID 16963084 DOI: 10.1016/J.Jmb.2006.08.016 |
0.549 |
|
| 2006 |
Joshi HK, Etzkorn C, Chatwell L, Bitinaite J, Horton NC. Alteration of sequence specificity of the type II restriction endonuclease HincII through an indirect readout mechanism. The Journal of Biological Chemistry. 281: 23852-69. PMID 16675462 DOI: 10.1074/Jbc.M512339200 |
0.613 |
|
| 2005 |
Crotty JW, Etzkorn C, Barbas CF, Segal DJ, Horton NC. Crystallization and preliminary X-ray crystallographic analysis of Aart, a designed six-finger zinc-finger peptide, bound to DNA. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 573-6. PMID 16511099 DOI: 10.1107/S1744309105014363 |
0.466 |
|
| 2005 |
Little EJ, Horton NC. DNA-induced conformational changes in type II restriction endonucleases: the structure of unliganded HincII. Journal of Molecular Biology. 351: 76-88. PMID 15993893 DOI: 10.1016/J.Jmb.2005.05.063 |
0.608 |
|
| 2004 |
Etzkorn C, Horton NC. Ca2+ binding in the active site of HincII: implications for the catalytic mechanism. Biochemistry. 43: 13256-70. PMID 15491133 DOI: 10.1021/Bi0490082 |
0.506 |
|
| 2004 |
Etzkorn C, Horton NC. Mechanistic insights from the structures of HincII bound to cognate DNA cleaved from addition of Mg2+ and Mn2+. Journal of Molecular Biology. 343: 833-49. PMID 15476804 DOI: 10.1016/J.Jmb.2004.08.082 |
0.545 |
|
| 2004 |
Horton NC, Perona JJ. DNA cleavage by EcoRV endonuclease: two metal ions in three metal ion binding sites. Biochemistry. 43: 6841-57. PMID 15170321 DOI: 10.1021/Bi0499056 |
0.491 |
|
| 2002 |
Horton NC, Otey C, Lusetti S, Sam MD, Kohn J, Martin AM, Ananthnarayan V, Perona JJ. Electrostatic contributions to site specific DNA cleavage by EcoRV endonuclease. Biochemistry. 41: 10754-63. PMID 12196013 DOI: 10.1021/Bi020305L |
0.563 |
|
| 2002 |
Horton NC, Dorner LF, Perona JJ. Sequence selectivity and degeneracy of a restriction endonuclease mediated by DNA intercalation. Nature Structural Biology. 9: 42-7. PMID 11742344 DOI: 10.1038/Nsb741 |
0.599 |
|
| 2001 |
Horton NC, Perona JJ. Making the most of metal ions Nature Structural Biology. 8: 290-293. PMID 11276242 DOI: 10.1038/86149 |
0.51 |
|
| 2001 |
Sam MD, Horton NC, Nissan TA, Perona JJ. Catalytic efficiency and sequence selectivity of a restriction endonuclease modulated by a distal manganese ion binding site. Journal of Molecular Biology. 306: 851-61. PMID 11243793 DOI: 10.1006/Jmbi.2000.4434 |
0.604 |
|
| 2000 |
Horton NC, Perona JJ. Crystallographic snapshots along a protein-induced DNA-bending pathway Proceedings of the National Academy of Sciences of the United States of America. 97: 5729-5734. PMID 10801972 DOI: 10.1073/Pnas.090370797 |
0.602 |
|
| 2000 |
Horton NC, Connolly BA, Perona JJ. Inhibition of EcoRV endonuclease by deoxyribo-3'-S-phosphorothiolates: A high-resolution X-ray crystallographic study Journal of the American Chemical Society. 122: 3314-3324. DOI: 10.1021/Ja993719J |
0.497 |
|
| 1999 |
Horton NC, Dorner LF, Schildkraut I, Perona JJ. Crystallization and preliminary diffraction analysis of the HincII restriction endonuclease-DNA complex Acta Crystallographica Section D: Biological Crystallography. 55: 1943-1945. PMID 10531503 DOI: 10.1107/S0907444999010574 |
0.437 |
|
| 1999 |
Martin AM, Horton NC, Lusetti S, Reich NO, Perona JJ. Divalent metal dependence of site-specific DNA binding by EcoRV endonuclease. Biochemistry. 38: 8430-9. PMID 10387089 DOI: 10.1021/Bi9905359 |
0.478 |
|
| 1998 |
Horton NC, Newberry KJ, Perona JJ. Metal ion-mediated substrate-assisted catalysis in type II restriction endonucleases. Proceedings of the National Academy of Sciences of the United States of America. 95: 13489-94. PMID 9811827 DOI: 10.1073/Pnas.95.23.13489 |
0.406 |
|
| 1998 |
Horton NC, Perona JJ. Recognition of flanking DNA sequences by EcoRV endonuclease involves alternative patterns of water-mediated contacts Journal of Biological Chemistry. 273: 21721-21729. PMID 9705308 DOI: 10.1074/Jbc.273.34.21721 |
0.537 |
|
| 1998 |
Baldwin ET, Sarver RW, Bryant GL, Curry KA, Fairbanks MB, Finzel BC, Garlick RL, Heinrikson RL, Horton NC, Kelley LL, Mildner AM, Moon JB, Mott JE, Mutchler VT, Tomich CS, et al. Cation binding to the integrin CD11b I domain and activation model assessment. Structure (London, England : 1993). 6: 923-35. PMID 9687375 DOI: 10.1016/S0969-2126(98)00093-8 |
0.318 |
|
| 1998 |
Horton NC, Perona JJ. Role of protein-induced bending in the specificity of DNA recognition: Crystal structure of EcoRV endonuclease complexed with d(AAAGAT) + d(ATCTT) Journal of Molecular Biology. 277: 779-787. PMID 9545372 DOI: 10.1006/Jmbi.1998.1655 |
0.602 |
|
| 1997 |
Horton N, Lewis M, Lu P. Escherichia coli lac repressor-lac operator interaction and the influence of allosteric effectors Journal of Molecular Biology. 265: 1-7. PMID 8995519 DOI: 10.1006/Jmbi.1996.0706 |
0.444 |
|
| 1996 |
Horton NC, Finzel BC. The structure of an RNA/DNA hybrid: a substrate of the ribonuclease activity of HIV-1 reverse transcriptase. Journal of Molecular Biology. 264: 521-33. PMID 8969302 DOI: 10.1006/Jmbi.1996.0658 |
0.45 |
|
| 1996 |
Lewis M, Chang G, Horton NC, Kercher MA, Pace HC, Schumacher MA, Brennan RG, Lu P. Crystal structure of the lactose operon represser and its complexes with DNA and inducer Science. 271: 1247-1254. PMID 8638105 DOI: 10.1126/Science.271.5253.1247 |
0.596 |
|
| 1996 |
Kercher MA, Chang G, Horton NC, Lu P, Miller JH, Pace HC, Lewis M. Structure of the lactose operon repressor and its complexes with DNA and inducer Acta Crystallographica Section a Foundations of Crystallography. 52: C156-C156. DOI: 10.1107/S0108767396093002 |
0.548 |
|
| 1996 |
Kercher MA, Chang G, Horton NC, Lu P, Miller JH, Pace HC, Lewis M. Structure and genetics of the lactose operon repressor Faseb Journal. 10. |
0.479 |
|
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