Trevor Owens - Publications

Affiliations: 
McGill University, Montreal, QC, Canada 
Area:
Immunology, Neuroscience Biology, Pathology

150 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Kronborg Hansen AK, Dubik M, Marczynska J, Ojha B, Nistal-Villán E, González Aseguinolaza G, Arengoth DS, Owens T, Khorooshi R. Targeting Signaling Pathway Downstream of RIG-I/MAVS in the CNS Stimulates Production of Endogenous Type I IFN and Suppresses EAE. International Journal of Molecular Sciences. 23. PMID 36232593 DOI: 10.3390/ijms231911292  0.316
2021 Dieu RS, Wais V, Sørensen MZ, Marczynska J, Dubik M, Kavan S, Thomassen M, Burton M, Kruse T, Khorooshi R, Owens T. Central Nervous System-Endogenous TLR7 and TLR9 Induce Different Immune Responses and Effects on Experimental Autoimmune Encephalomyelitis. Frontiers in Neuroscience. 15: 685645. PMID 34211367 DOI: 10.3389/fnins.2021.685645  0.405
2021 Dubik M, Marczynska J, Mørch MT, Webster G, Jensen KN, Wlodarczyk A, Khorooshi R, Owens T. Innate Signaling in the CNS Prevents Demyelination in a Focal EAE Model. Frontiers in Neuroscience. 15: 682451. PMID 34149350 DOI: 10.3389/fnins.2021.682451  0.381
2020 Wlodarczyk A, Khorooshi R, Marczynska J, Holtman IR, Burton M, Jensen KN, Blaabjerg M, Meyer M, Thomassen M, Eggen BJL, Asgari N, Owens T. Type I interferon-activated microglia are critical for neuromyelitis optica pathology. Glia. PMID 33241604 DOI: 10.1002/glia.23938  0.334
2020 Owens T, Benmamar-Badel A, Wlodarczyk A, Marczynska J, Mørch MT, Dubik M, Arengoth DS, Asgari N, Webster G, Khorooshi R. Protective roles for myeloid cells in neuroinflammation. Scandinavian Journal of Immunology. e12963. PMID 32851668 DOI: 10.1111/Sji.12963  0.471
2020 Martin NA, Hyrlov KH, Elkjaer ML, Thygesen EK, Wlodarczyk A, Elbaek KJ, Aboo C, Okarmus J, Benedikz E, Reynolds R, Hegedus Z, Stensballe A, Svenningsen ÅF, Owens T, Illes Z. Absence of miRNA-146a Differentially Alters Microglia Function and Proteome. Frontiers in Immunology. 11: 1110. PMID 32582192 DOI: 10.3389/Fimmu.2020.01110  0.324
2020 Khorooshi R, Marczynska J, Dieu RS, Wais V, Hansen CR, Kavan S, Thomassen M, Burton M, Kruse T, Webster GA, Owens T. Innate signaling within the central nervous system recruits protective neutrophils. Acta Neuropathologica Communications. 8: 2. PMID 31915070 DOI: 10.1186/S40478-019-0876-2  0.506
2019 Khorooshi R, Tofte-Hansen EU, Tygesen C, Montanana-Rosell R, Limburg HL, Marczynska J, Asgari N, Steckelings UM, Owens T. Angiotensin AT2 receptor-induced interleukin-10 attenuates neuromyelitis optica spectrum disorder-like pathology. Multiple Sclerosis (Houndmills, Basingstoke, England). 1352458519860327. PMID 31287367 DOI: 10.1177/1352458519860327  0.339
2018 Wlodarczyk A, Benmamar-Badel A, Cédile O, Jensen KN, Kramer I, Elsborg NB, Owens T. CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+ Microglia in EAE. Frontiers in Cellular Neuroscience. 12: 523. PMID 30687013 DOI: 10.3389/Fncel.2018.00523  0.436
2018 Mørch MT, Sørensen SF, Khorooshi R, Asgari N, Owens T. Selective localization of IgG from cerebrospinal fluid to brain parenchyma. Journal of Neuroinflammation. 15: 110. PMID 29665816 DOI: 10.1186/S12974-018-1159-8  0.331
2018 Martin NA, Molnar V, Szilagyi GT, Elkjaer ML, Nawrocki A, Okarmus J, Wlodarczyk A, Thygesen EK, Palkovits M, Gallyas F, Larsen MR, Lassmann H, Benedikz E, Owens T, Svenningsen AF, et al. Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice. Frontiers in Immunology. 9: 490. PMID 29593734 DOI: 10.3389/Fimmu.2018.00490  0.317
2017 Cédile O, Jørgensen LØ, Frank I, Wlodarczyk A, Owens T. The chemokine receptor CCR2 maintains plasmacytoid dendritic cell homeostasis. Immunology Letters. 192: 72-78. PMID 29106985 DOI: 10.1016/J.Imlet.2017.10.012  0.425
2017 Prajeeth CK, Kronisch J, Khorooshi R, Knier B, Toft-Hansen H, Gudi V, Floess S, Huehn J, Owens T, Korn T, Stangel M. Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties. Journal of Neuroinflammation. 14: 204. PMID 29037246 DOI: 10.1186/S12974-017-0978-3  0.406
2017 Wlodarczyk A, Holtman IR, Krueger M, Yogev N, Bruttger J, Khorooshi R, Benmamar-Badel A, de Boer-Bergsma JJ, Martin NA, Karram K, Kramer I, Boddeke EW, Waisman A, Eggen BJ, Owens T. A novel microglial subset plays a key role in myelinogenesis in developing brain. The Embo Journal. PMID 28963396 DOI: 10.15252/Embj.201696056  0.422
2017 Cédile O, Wlodarczyk A, Owens T. CCL2 recruits T cells into the brain in a CCR2-independent manner. Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. PMID 28836736 DOI: 10.1111/Apm.12740  0.502
2017 Berg CT, Khorooshi R, Asgari N, Owens T. Influence of type I IFN signaling on anti-MOG antibody-mediated demyelination. Journal of Neuroinflammation. 14: 127. PMID 28646890 DOI: 10.1186/S12974-017-0899-1  0.337
2016 Wlodarczyk A, Holtman IR, Bruttger J, Yogev N, Boer-Bergsma JJd, Jensen KN, Martin NA, Karram K, Boddeke EWGM, Waisman A, Eggen BJL, Owens T. Protective roles for microglia inneuroinflammation Scandinavian Journal of Immunology. 83. DOI: 10.1111/Sji.12431  0.336
2015 Khorooshi R, Asgari N, Mørch MT, Berg CT, Owens T. Hypersensitivity Responses in the Central Nervous System. Frontiers in Immunology. 6: 517. PMID 26500654 DOI: 10.3389/Fimmu.2015.00517  0.483
2015 Cho HS, Shin HM, Haberstock-Debic H, Xing Y, Owens TD, Funk JO, Hill RJ, Bradshaw JM, Berg LJ. A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression. Journal of Immunology (Baltimore, Md. : 1950). PMID 26466958 DOI: 10.4049/Jimmunol.1501828  0.323
2015 Wlodarczyk A, Cédile O, Jensen KN, Jasson A, Mony JT, Khorooshi R, Owens T. Pathologic and Protective Roles for Microglial Subsets and Bone Marrow- and Blood-Derived Myeloid Cells in Central Nervous System Inflammation. Frontiers in Immunology. 6: 463. PMID 26441968 DOI: 10.3389/Fimmu.2015.00463  0.507
2015 Khorooshi R, Mørch MT, Holm TH, Berg CT, Dieu RT, Dræby D, Issazadeh-Navikas S, Weiss S, Lienenklaus S, Owens T. Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis. Acta Neuropathologica. 130: 107-18. PMID 25869642 DOI: 10.1007/S00401-015-1418-Z  0.419
2015 Owens T, Khorooshi RMH, Mørch M, Wlodarczyk A, Hermansen C, Steckelings UM. Microglial regulation of CNS inflammation Irish Journal of Medical Science. 184. PMID 25604015 DOI: 10.1007/S11845-014-1239-4  0.377
2015 Cédile O, Løbner M, Toft-Hansen H, Frank I, Wlodarczyk A, Irla M, Owens T. Thymic CCL2 influences induction of T-cell tolerance Journal of Autoimmunity. 55: 73-85. PMID 25129504 DOI: 10.1016/J.Jaut.2014.07.004  0.47
2014 Mony JT, Khorooshi R, Owens T. Chemokine receptor expression by inflammatory T cells in EAE. Frontiers in Cellular Neuroscience. 8: 187. PMID 25071447 DOI: 10.3389/Fncel.2014.00187  0.457
2014 Wlodarczyk A, Løbner M, Cédile O, Owens T. Comparison of microglia and infiltrating CD11c⁺ cells as antigen presenting cells for T cell proliferation and cytokine response. Journal of Neuroinflammation. 11: 57. PMID 24666681 DOI: 10.1186/1742-2094-11-57  0.464
2014 Biber K, Owens T, Boddeke E. What is microglia neurotoxicity (Not)? Glia. 62: 841-54. PMID 24590682 DOI: 10.1002/Glia.22654  0.381
2014 Owens T, Khorooshi R, Wlodarczyk A, Asgari N. Interferons in the central nervous system: a few instruments play many tunes. Glia. 62: 339-55. PMID 24588027 DOI: 10.1002/Glia.22608  0.385
2014 Mony JT, Khorooshi R, Owens T. MOG extracellular domain (p1-125) triggers elevated frequency of CXCR3+ CD4+ Th1 cells in the CNS of mice and induces greater incidence of severe EAE. Multiple Sclerosis (Houndmills, Basingstoke, England). 20: 1312-21. PMID 24552747 DOI: 10.1177/1352458514524086  0.461
2014 Cédile O, Løbner M, Toft-hansen H, Frank I, Wlodarczyk A, Irla M, Owens T. CCL2 chemokine in T cell tolerance and protection against experimental autoimmune encephalomyelitis Journal of Neuroimmunology. 275: 197. DOI: 10.1016/J.Jneuroim.2014.08.529  0.414
2014 Kandiyil PC, Kornisch J, Khorooshi R, Toft-hansen H, Löhr K, Owens T, Huehn J, Stangel M. Influence of effector molecules released by Th1 and Th17 cells on glial cells Journal of Neuroimmunology. 275: 144. DOI: 10.1016/J.Jneuroim.2014.08.385  0.334
2014 Khorooshi RMH, Holm T, Berg CT, Mørch M, Dieu RT, Dræby D, Weiss S, Lienenklaus S, Owens T. Induction of type I interferon in the central nervous system plays a protective role in EAE Journal of Neuroimmunology. 275: 86-87. DOI: 10.1016/J.Jneuroim.2014.08.231  0.367
2014 Berg CT, Khorooshi RMH, Asgari N, Owens T. Mechanisms underlying induction of antibody-mediated demyelination in muliple sclerosis Journal of Neuroimmunology. 275: 55-56. DOI: 10.1016/J.Jneuroim.2014.08.146  0.311
2013 Khorooshi R, Wlodarczyk A, Asgari N, Owens T. Neuromyelitis optica-like pathology is dependent on type I interferon response. Experimental Neurology. 247: 744-7. PMID 23434493 DOI: 10.1016/J.Expneurol.2013.02.005  0.423
2013 Khorooshi R, Owens T. Detection and cellular localization of phospho-STAT2 in the central nervous system by immunohistochemical staining. Methods in Molecular Biology (Clifton, N.J.). 967: 179-88. PMID 23296730 DOI: 10.1007/978-1-62703-242-1_13  0.336
2013 Asgari N, Khorooshi R, Lillevang ST, Owens T. Complement-dependent pathogenicity of brain-specific antibodies in cerebrospinal fluid. Journal of Neuroimmunology. 254: 76-82. PMID 23031833 DOI: 10.1016/J.Jneuroim.2012.09.010  0.33
2013 Maiorino C, Khorooshi R, Ruffini F, Løbner M, Bergami A, Garzetti L, Martino G, Owens T, Furlan R. Lentiviral-mediated administration of IL-25 in the CNS induces alternative activation of microglia Gene Therapy. 20: 487-496. PMID 22855093 DOI: 10.1038/Gt.2012.58  0.432
2012 Schellenberg AE, Buist R, Del Bigio MR, Toft-Hansen H, Khorooshi R, Owens T, Peeling J. Blood-brain barrier disruption in CCL2 transgenic mice during pertussis toxin-induced brain inflammation. Fluids and Barriers of the Cns. 9: 10. PMID 22546091 DOI: 10.1186/2045-8118-9-10  0.414
2012 Reinert LS, Harder L, Holm CK, Iversen MB, Horan KA, Dagnæs-Hansen F, Ulhøi BP, Holm TH, Mogensen TH, Owens T, Nyengaard JR, Thomsen AR, Paludan SR. TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice. The Journal of Clinical Investigation. 122: 1368-76. PMID 22426207 DOI: 10.1172/Jci60893  0.4
2012 Holm TH, Draeby D, Owens T. Microglia are required for astroglial Toll-like receptor 4 response and for optimal TLR2 and TLR3 response. Glia. 60: 630-8. PMID 22271465 DOI: 10.1002/Glia.22296  0.353
2011 Salem M, Mony JT, Løbner M, Khorooshi R, Owens T. Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice. Journal of Neuroinflammation. 8: 181. PMID 22196084 DOI: 10.1186/1742-2094-8-181  0.388
2011 Hvilsted Nielsen H, Toft-Hansen H, Lambertsen KL, Owens T, Finsen B. Stimulation of adult oligodendrogenesis by myelin-specific T cells. The American Journal of Pathology. 179: 2028-41. PMID 21872562 DOI: 10.1016/J.Ajpath.2011.06.006  0.424
2011 Finsen B, Owens T. Innate immune responses in central nervous system inflammation. Febs Letters. 585: 3806-12. PMID 21624366 DOI: 10.1016/J.Febslet.2011.05.030  0.481
2011 Toft-Hansen H, Füchtbauer L, Owens T. Inhibition of reactive astrocytosis in established experimental autoimmune encephalomyelitis favors infiltration by myeloid cells over T cells and enhances severity of disease. Glia. 59: 166-76. PMID 21046558 DOI: 10.1002/Glia.21088  0.509
2011 Asgari N, Owens T, Frøkiær J, Stenager E, Lillevang ST, Kyvik KO. Neuromyelitis optica (NMO)--an autoimmune disease of the central nervous system (CNS). Acta Neurologica Scandinavica. 123: 369-384. PMID 20880299 DOI: 10.1111/J.1600-0404.2010.01416.X  0.401
2011 Füchtbauer L, Groth-Rasmussen M, Holm TH, Løbner M, Toft-Hansen H, Khorooshi R, Owens T. Angiotensin II Type 1 receptor (AT1) signaling in astrocytes regulates synaptic degeneration-induced leukocyte entry to the central nervous system. Brain, Behavior, and Immunity. 25: 897-904. PMID 20868737 DOI: 10.1016/J.Bbi.2010.09.015  0.429
2010 Millward JM, Løbner M, Wheeler RD, Owens T. Inflammation in the central nervous system and Th17 responses are inhibited by IFN-gamma-Induced IL-18 binding protein. Journal of Immunology (Baltimore, Md. : 1950). 185: 2458-66. PMID 20644165 DOI: 10.4049/Jimmunol.0902153  0.381
2010 Khorooshi R, Owens T. Injury-induced type I IFN signaling regulates inflammatory responses in the central nervous system. Journal of Immunology (Baltimore, Md. : 1950). 185: 1258-64. PMID 20562259 DOI: 10.4049/Jimmunol.0901753  0.401
2010 Millward JM, Holst PJ, Høgh-Petersen M, Thomsen AR, Christensen JP, Owens T. The murine gammaherpesvirus-68 chemokine-binding protein M3 inhibits experimental autoimmune encephalomyelitis. Journal of Neuroimmunology. 224: 45-50. PMID 20537410 DOI: 10.1016/J.Jneuroim.2010.05.005  0.402
2010 Füchtbauer L, Toft-Hansen H, Khorooshi R, Owens T. Expression of astrocytic type 2 angiotensin receptor in central nervous system inflammation correlates with blood-brain barrier breakdown. Journal of Molecular Neuroscience : Mn. 42: 89-98. PMID 20414743 DOI: 10.1007/S12031-010-9371-8  0.392
2010 Hollmann A, Aloyz R, Baker K, Dirnhofer S, Owens T, Sladek R, Tzankov A. Vav-1 expression correlates with NFκB activation and CD40-mediated cell death in diffuse large B-cell lymphoma cell lines. Hematological Oncology. 28: 142-50. PMID 20155735 DOI: 10.1002/Hon.935  0.339
2009 Owens T. Toll-like receptors in neurodegeneration. Current Topics in Microbiology and Immunology. 336: 105-20. PMID 19688330 DOI: 10.1007/978-3-642-00549-7_6  0.327
2009 Nielsen HH, Ladeby R, Fenger C, Toft-Hansen H, Babcock AA, Owens T, Finsen B. Enhanced microglial clearance of myelin debris in T cell-infiltrated central nervous system. Journal of Neuropathology and Experimental Neurology. 68: 845-56. PMID 19606068 DOI: 10.1097/Nen.0B013E3181Ae0236  0.449
2009 Miron VE, Zehntner SP, Kuhlmann T, Ludwin SK, Owens T, Kennedy TE, Bedell BJ, Antel JP. Statin therapy inhibits remyelination in the central nervous system. The American Journal of Pathology. 174: 1880-90. PMID 19349355 DOI: 10.2353/Ajpath.2009.080947  0.38
2008 Owens T, Bechmann I, Engelhardt B. Perivascular spaces and the two steps to neuroinflammation. Journal of Neuropathology and Experimental Neurology. 67: 1113-21. PMID 19018243 DOI: 10.1097/Nen.0B013E31818F9Ca8  0.408
2008 Khorooshi R, Babcock AA, Owens T. NF-kappaB-driven STAT2 and CCL2 expression in astrocytes in response to brain injury. Journal of Immunology (Baltimore, Md. : 1950). 181: 7284-91. PMID 18981150 DOI: 10.4049/Jimmunol.181.10.7284  0.386
2008 Babcock AA, Toft-Hansen H, Owens T. Signaling through MyD88 regulates leukocyte recruitment after brain injury. Journal of Immunology (Baltimore, Md. : 1950). 181: 6481-90. PMID 18941239 DOI: 10.4049/Jimmunol.181.9.6481  0.431
2008 Fux M, van Rooijen N, Owens T. Macrophage-independent T cell infiltration to the site of injury-induced brain inflammation. Journal of Neuroimmunology. 203: 64-72. PMID 18653241 DOI: 10.1016/J.Jneuroim.2008.06.025  0.488
2008 Baron R, Nemirovsky A, Harpaz I, Cohen H, Owens T, Monsonego A. IFN-gamma enhances neurogenesis in wild-type mice and in a mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 2843-52. PMID 18390924 DOI: 10.1096/Fj.08-105866  0.423
2007 Zehntner SP, Bourbonnière L, Moore CS, Morris SJ, Methot D, St Jean M, Lacasse E, Hebb AL, Robertson GS, Durkin J, Gillard JW, Owens T. X-linked inhibitor of apoptosis regulates T cell effector function. Journal of Immunology (Baltimore, Md. : 1950). 179: 7553-60. PMID 18025200 DOI: 10.4049/Jimmunol.179.11.7553  0.452
2007 Weiss HA, Millward JM, Owens T. CD8+ T cells in inflammatory demyelinating disease. Journal of Neuroimmunology. 191: 79-85. PMID 17920696 DOI: 10.1016/J.Jneuroim.2007.09.011  0.432
2007 Toft-Hansen H, Babcock AA, Millward JM, Owens T. Downregulation of membrane type-matrix metalloproteinases in the inflamed or injured central nervous system. Journal of Neuroinflammation. 4: 24. PMID 17883829 DOI: 10.1186/1742-2094-4-24  0.31
2007 Larsen PH, Holm TH, Owens T. Toll-like receptors in brain development and homeostasis. Science's Stke : Signal Transduction Knowledge Environment. 2007: pe47. PMID 17785714 DOI: 10.1126/Stke.4022007Pe47  0.365
2007 Millward JM, Caruso M, Campbell IL, Gauldie J, Owens T. IFN-gamma-induced chemokines synergize with pertussis toxin to promote T cell entry to the central nervous system. Journal of Immunology (Baltimore, Md. : 1950). 178: 8175-82. PMID 17548656 DOI: 10.4049/Jimmunol.178.12.8175  0.482
2007 Remington LT, Babcock AA, Zehntner SP, Owens T. Microglial recruitment, activation, and proliferation in response to primary demyelination. The American Journal of Pathology. 170: 1713-24. PMID 17456776 DOI: 10.2353/Ajpath.2007.060783  0.476
2007 Kuhlmann T, Remington L, Maruschak B, Owens T, Brück W. Nogo-A is a reliable oligodendroglial marker in adult human and mouse CNS and in demyelinated lesions. Journal of Neuropathology and Experimental Neurology. 66: 238-46. PMID 17356385 DOI: 10.1097/01.Jnen.0000248559.83573.71  0.359
2007 Lambertsen KL, Clausen BH, Fenger C, Wulf H, Owens T, Dagnaes-Hansen F, Meldgaard M, Finsen B. Microglia and macrophages express tumor necrosis factor receptor p75 following middle cerebral artery occlusion in mice. Neuroscience. 144: 934-949. PMID 17161916 DOI: 10.1016/J.Neuroscience.2006.10.046  0.362
2006 Babcock AA, Wirenfeldt M, Holm T, Nielsen HH, Dissing-Olesen L, Toft-Hansen H, Millward JM, Landmann R, Rivest S, Finsen B, Owens T. Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12826-37. PMID 17151286 DOI: 10.1523/Jneurosci.4937-05.2006  0.43
2006 Toft-Hansen H, Buist R, Sun XJ, Schellenberg A, Peeling J, Owens T. Metalloproteinases control brain inflammation induced by pertussis toxin in mice overexpressing the chemokine CCL2 in the central nervous system. Journal of Immunology (Baltimore, Md. : 1950). 177: 7242-9. PMID 17082642 DOI: 10.4049/Jimmunol.177.10.7242  0.423
2006 Brisebois M, Zehntner SP, Estrada J, Owens T, Fournier S. A pathogenic role for CD8+ T cells in a spontaneous model of demyelinating disease. Journal of Immunology (Baltimore, Md. : 1950). 177: 2403-11. PMID 16888002 DOI: 10.4049/Jimmunol.177.4.2403  0.47
2006 Kuhlmann T, Remington L, Cognet I, Bourbonniere L, Zehntner S, Guilhot F, Herman A, Guay-Giroux A, Antel JP, Owens T, Gauchat JF. Continued administration of ciliary neurotrophic factor protects mice from inflammatory pathology in experimental autoimmune encephalomyelitis. The American Journal of Pathology. 169: 584-98. PMID 16877358 DOI: 10.2353/Ajpath.2006.051086  0.448
2006 Wheeler RD, Zehntner SP, Kelly LM, Bourbonnière L, Owens T. Elevated interferon gamma expression in the central nervous system of tumour necrosis factor receptor 1-deficient mice with experimental autoimmune encephalomyelitis. Immunology. 118: 527-38. PMID 16780563 DOI: 10.1111/J.1365-2567.2006.02395.X  0.482
2006 Hollmann CA, Owens T, Nalbantoglu J, Hudson TJ, Sladek R. Constitutive activation of extracellular signal-regulated kinase predisposes diffuse large B-cell lymphoma cell lines to CD40-mediated cell death. Cancer Research. 66: 3550-7. PMID 16585179 DOI: 10.1158/0008-5472.Can-05-2498  0.312
2006 Monsonego A, Imitola J, Petrovic S, Zota V, Nemirovsky A, Baron R, Fisher Y, Owens T, Weiner HL. Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 103: 5048-53. PMID 16549802 DOI: 10.1073/Pnas.0506209103  0.404
2005 Wirenfeldt M, Babcock AA, Ladeby R, Lambertsen KL, Dagnaes-Hansen F, Leslie RG, Owens T, Finsen B. Reactive microgliosis engages distinct responses by microglial subpopulations after minor central nervous system injury. Journal of Neuroscience Research. 82: 507-14. PMID 16237722 DOI: 10.1002/Jnr.20659  0.401
2005 Owens T, Babcock AA, Millward JM, Toft-Hansen H. Cytokine and chemokine inter-regulation in the inflamed or injured CNS. Brain Research. Brain Research Reviews. 48: 178-84. PMID 15850656 DOI: 10.1016/J.Brainresrev.2004.12.007  0.463
2005 Zehntner SP, Brickman C, Bourbonnière L, Remington L, Caruso M, Owens T. Neutrophils that infiltrate the central nervous system regulate T cell responses. Journal of Immunology (Baltimore, Md. : 1950). 174: 5124-31. PMID 15814744 DOI: 10.4049/Jimmunol.174.8.5124  0.508
2005 Ladeby R, Wirenfeldt M, Dalmau I, Gregersen R, García-Ovejero D, Babcock A, Owens T, Finsen B. Proliferating resident microglia express the stem cell antigen CD34 in response to acute neural injury. Glia. 50: 121-31. PMID 15657941 DOI: 10.1002/Glia.20159  0.367
2005 Owens T. Toll-like receptors on astrocytes: patterning for immunity. Journal of Neuroimmunology. 159: 1-2. PMID 15652397 DOI: 10.1016/J.Jneuroim.2004.10.015  0.318
2004 Toft-Hansen H, Nuttall RK, Edwards DR, Owens T. Key metalloproteinases are expressed by specific cell types in experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 173: 5209-18. PMID 15470066 DOI: 10.4049/Jimmunol.173.8.5209  0.368
2004 Lambertsen KL, Gregersen R, Meldgaard M, Clausen BH, Heibøl EK, Ladeby R, Knudsen J, Frandsen A, Owens T, Finsen B. A role for interferon-gamma in focal cerebral ischemia in mice. Journal of Neuropathology and Experimental Neurology. 63: 942-55. PMID 15453093 DOI: 10.1093/Jnen/63.9.942  0.442
2004 Antel J, Owens T. Multiple sclerosis and immune regulatory cells. Brain : a Journal of Neurology. 127: 1915-6. PMID 15321939 DOI: 10.1093/Brain/Awh272  0.476
2004 Zehntner SP, Bourbonniere L, Hassan-Zahraee M, Tran E, Owens T. Bone marrow-derived versus parenchymal sources of inducible nitric oxide synthase in experimental autoimmune encephalomyelitis. Journal of Neuroimmunology. 150: 70-9. PMID 15081250 DOI: 10.1016/J.Jneuroim.2004.01.020  0.741
2004 Drøjdahl N, Fenger C, Nielsen HH, Owens T, Finsen B. Dynamics of oligodendrocyte responses to anterograde axonal (Wallerian) and terminal degeneration in normal and TNF-transgenic mice. Journal of Neuroscience Research. 75: 203-17. PMID 14705141 DOI: 10.1002/Jnr.10860  0.383
2003 Babcock AA, Kuziel WA, Rivest S, Owens T. Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7922-30. PMID 12944523 DOI: 10.1523/Jneurosci.23-21-07922.2003  0.464
2003 Zehntner SP, Brisebois M, Tran E, Owens T, Fournier S. Constitutive expression of a costimulatory ligand on antigen-presenting cells in the nervous system drives demyelinating disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1910-2. PMID 12923072 DOI: 10.1096/Fj.03-0199Fje  0.77
2003 Owens T. The enigma of multiple sclerosis: inflammation and neurodegeneration cause heterogeneous dysfunction and damage. Current Opinion in Neurology. 16: 259-65. PMID 12858060 DOI: 10.1097/01.Wco.0000073925.19076.F2  0.379
2003 Babcock A, Owens T. Chemokines in experimental autoimmune encephalomyelitis and multiple sclerosis. Advances in Experimental Medicine and Biology. 520: 120-32. PMID 12613576 DOI: 10.1007/978-1-4615-0171-8_8  0.37
2002 Finsen B, Antel J, Owens T. TNFalpha: kill or cure for demyelinating disease? Molecular Psychiatry. 7: 820-821. PMID 12232770 DOI: 10.1038/Sj.Mp.4001120  0.312
2002 Owens T. Identification of new therapeutic targets for prevention of CNS inflammation. Expert Opinion On Therapeutic Targets. 6: 203-15. PMID 12223081 DOI: 10.1517/14728222.6.2.203  0.497
2002 Owens T, Babcock A. Immune response induction in the central nervous system. Frontiers in Bioscience : a Journal and Virtual Library. 7: d427-38. PMID 11815294 DOI: 10.2741/Owens  0.398
2001 Lambertsen KL, Gregersen R, Drøjdahl N, Owens T, Finsen B. A specific and sensitive method for visualization of tumor necrosis factor in the murine central nervous system. Brain Research Protocols. 7: 175-191. PMID 11356385 DOI: 10.1016/S1385-299X(01)00062-9  0.354
2001 Doyle IS, Hollmann CA, Crispe IN, Owens T. Specific blockade by CD54 and MHC II of CD40-mediated signaling for B cell proliferation and survival. Experimental Cell Research. 265: 312-318. PMID 11302697 DOI: 10.1006/Excr.2001.5183  0.339
2001 Owens T, Wekerle H, Antel J. Genetic models for CNS inflammation. Nature Medicine. 7: 161-6. PMID 11175845 DOI: 10.1038/84603  0.391
2001 Owens T, Tran EH, Hassan-Zahraee M, Babcock A, Krakowski ML, Fournier S, Jensen MB, Finsen B. The pathogenesis of encephalitis Neuroimmune Biology. 1: 387-397. DOI: 10.1016/S1567-7443(01)80035-1  0.8
2000 Hassan-Zahraee M, Tran EH, Bourbonnière L, Owens T. Elevated interferon-gamma in CNS inflammatory disease: a potential complication for bone marrow reconstitution in MS. Journal of Neuroimmunology. 108: 40-4. PMID 10900335 DOI: 10.1016/S0165-5728(99)00263-5  0.729
2000 Tran EH, Kuziel WA, Owens T. Induction of experimental autoimmune encephalomyelitis in C57BL/6 mice deficient in either the chemokine macrophage inflammatory protein-1alpha or its CCR5 receptor. European Journal of Immunology. 30: 1410-5. PMID 10820388 DOI: 10.1002/(Sici)1521-4141(200005)30:5<1410::Aid-Immu1410>3.0.Co;2-L  0.767
2000 Krakowski ML, Owens T. Naive T lymphocytes traffic to inflamed central nervous system, but require antigen recognition for activation European Journal of Immunology. 30: 1002-1009. PMID 10760787 DOI: 10.1002/(Sici)1521-4141(200004)30:4<1002::Aid-Immu1002>3.0.Co;2-2  0.448
2000 Tran EH, Prince EN, Owens T. IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines. Journal of Immunology (Baltimore, Md. : 1950). 164: 2759-68. PMID 10679118 DOI: 10.4049/Jimmunol.164.5.2759  0.769
2000 Hassan-Zahraee M, Ladiwala U, Lavoie PM, McCrea E, Sekaly RP, Owens T, Antel JP. Superantigen presenting capacity of human astrocytes Journal of Neuroimmunology. 102: 131-136. PMID 10636481 DOI: 10.1016/S0165-5728(99)00174-5  0.367
2000 Jensen MB, Hegelund IV, Lomholt ND, Finsen B, Owens T. IFNγ Enhances Microglial Reactions to Hippocampal Axonal Degeneration The Journal of Neuroscience. 20: 3612-3621. DOI: 10.1523/Jneurosci.20-10-03612.2000  0.417
1999 Antel JP, Owens T. Immune regulation and CNS autoimmune disease. Journal of Neuroimmunology. 100: 181-189. PMID 10695728 DOI: 10.1016/S0165-5728(99)00186-1  0.394
1999 Jensen MB, Hegelund IV, Poulsen FR, Owens T, Zimmer J, Finsen B. Microglial reactivity correlates to the density and the myelination of the anterogradely degenerating axons and terminals following perforant path denervation of the mouse fascia dentata. Neuroscience. 93: 507-18. PMID 10465434 DOI: 10.1016/S0306-4522(99)00139-6  0.309
1999 Glabinski AR, Krakowski M, Han Y, Owens T, Ransohoff RM. Chemokine expression in GKO mice (lacking interferon-gamma) with experimental autoimmune encephalomyelitis Journal of Neurovirology. 5: 95-101. PMID 10190695 DOI: 10.3109/13550289909029750  0.504
1998 Chagnon F, Lamarre A, Lachance C, Krakowski M, Owens T, Laliberté JF, Talbot PJ. Characterization of the expression and immunogenicity of the ns4b protein of human coronavirus 229E. Canadian Journal of Microbiology. 44: 1012-7. PMID 9933919 DOI: 10.1139/Cjm-44-10-1012  0.305
1998 Owens T, Tran E, Hassan-Zahraee M, Krakowski M. Immune cell entry to the CNS - A focus for immunoregulation of EAE Research in Immunology. 149. PMID 9923633 DOI: 10.1016/S0923-2494(99)80005-4  0.769
1998 Renno T, Taupin V, Bourbonnière L, Verge G, Tran E, De Simone R, Krakowski M, Rodriguez M, Peterson A, Owens T. Interferon-gamma in progression to chronic demyelination and neurological deficit following acute EAE. Molecular and Cellular Neurosciences. 12: 376-89. PMID 9888990 DOI: 10.1006/Mcne.1998.0725  0.501
1998 Tran EH, Hoekstra K, van Rooijen N, Dijkstra CD, Owens T. Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. Journal of Immunology (Baltimore, Md. : 1950). 161: 3767-75. PMID 9759903  0.787
1998 Becher B, Owens T, Antel JP, Barker PA. CD95-CD95L: Can the brain learn from the immune system? Trends in Neurosciences. 21: 114-117. PMID 9530918 DOI: 10.1016/S0166-2236(97)01180-6  0.418
1998 Vowinckel E, Reutens D, Becher B, Verge G, Evans A, Owens T, Antel JP. PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis. Journal of Neuroscience Research. 50: 345-53. PMID 9373043 DOI: 10.1002/(Sici)1097-4547(19971015)50:2<345::Aid-Jnr22>3.0.Co;2-5  0.426
1998 Lomholt ND, Jensen MB, Owens T, Finsen B. Role of TNF in oligodendrocyte development and response to anterograde axonal degeneration Journal of Neuroimmunology. 90: 30. DOI: 10.1016/S0165-5728(98)91355-8  0.312
1998 Hegelund IV, Jensen MB, Agger R, Owens T, Finsen B. A role for TNFα in glial activation, myelin degradation and lesion-induced axonal sprouting Journal of Neuroimmunology. 90: 28. DOI: 10.1016/S0165-5728(98)91345-5  0.323
1998 Tran E, Hoekstra K, van Rooijen N, Dijkstra C, Owens T. Macrophages modulate immune invasion of the central nervous system Journal of Neuroimmunology. 90: 22. DOI: 10.1016/S0165-5728(98)91310-8  0.732
1997 Krakowski ML, Owens T. The central nervous system environment controls effector CD4+ T cell cytokine profile in experimental allergic encephalomyelitis European Journal of Immunology. 27: 2840-2847. PMID 9394808 DOI: 10.1002/Eji.1830271115  0.498
1997 Hardin-Pouzet H, Krakowski M, Bourbonnière L, Didier-Bazes M, Tran E, Owens T. Glutamate metabolism is down-regulated in astrocytes during experimental allergic encephalomyelitis Glia. 20: 79-85. PMID 9145307 DOI: 10.1002/(Sici)1098-1136(199705)20:1<79::Aid-Glia8>3.0.Co;2-0  0.738
1997 Taupin V, Renno T, Bourbonnière L, Peterson AC, Rodriguez M, Owens T. Increased severity of experimental autoimmune encephalomyelitis, chronic macrophage/microglial reactivity, and demyelination in transgenic mice producing tumor necrosis factor-alpha in the central nervous system. European Journal of Immunology. 27: 905-13. PMID 9130643 DOI: 10.1002/Eji.1830270416  0.454
1997 Tran EH, Hardin-Pouzet H, Verge G, Owens T. Astrocytes and microglia express inducible nitric oxide synthase in mice with experimental allergic encephalomyelitis. Journal of Neuroimmunology. 74: 121-9. PMID 9119964 DOI: 10.1016/S0165-5728(96)00215-9  0.765
1997 Holland J, Owens T. Signaling through Intercellular Adhesion Molecule 1 (ICAM-1) in a B Cell Lymphoma Line THE ACTIVATION OF Lyn TYROSINE KINASE AND THE MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY Journal of Biological Chemistry. 272: 9108-9112. PMID 9083038 DOI: 10.1074/Jbc.272.14.9108  0.324
1997 Rostworowski M, Balasingam V, Chabot S, Owens T, Yong VW. Astrogliosis in the Neonatal and Adult Murine Brain Post-Trauma: Elevation of Inflammatory Cytokines and the Lack of Requirement for Endogenous Interferon-γ The Journal of Neuroscience. 17: 3664-3674. DOI: 10.1523/Jneurosci.17-10-03664.1997  0.36
1996 Antel JP, Becher B, Owens T. Immunotherapy for multiple sclerosis: From theory to practice Nature Medicine. 2: 1074-1075. PMID 8837599 DOI: 10.1038/Nm1096-1074  0.301
1996 Owens T. T-cell costimulation: T cells themselves call the shots Current Biology. 6: 32-35. PMID 8805218 DOI: 10.1016/S0960-9822(02)00415-3  0.43
1996 Krakowski M, Owens T. Interferon-γ confers resistance to experimental allergic encephalomyelitis European Journal of Immunology. 26: 1641-1646. PMID 8766573 DOI: 10.1002/Eji.1830260735  0.446
1995 Poudrier J, Owens T. Th1 and Th2 help for B cells: differential capacity for induction of autonomous responsiveness to IL-2 International Immunology. 7: 1021-1027. PMID 7577796 DOI: 10.1093/Intimm/7.6.1021  0.337
1995 Owens T, Sriram S. The Immunology of Multiple Sclerosis and its Animal Model, Experimental Allergic Encephalomyelitis Neurologic Clinics. 13: 51-73. DOI: 10.1016/S0733-8619(18)30061-6  0.343
1994 Renno T, Lin J, Piccirillo C, Antel J, Owens T. Cytokine production by cells in cerebrospinal fluid during experimental allergic encephalomyelitis in SJL/J mice Journal of Neuroimmunology. 49: 1-7. PMID 8294548 DOI: 10.1016/0165-5728(94)90174-0  0.477
1994 Renno T, Zeine R, Girard JM, Gillani S, Dodelet V, Owens T. Selective enrichment of Th1 CD45RBlow CD4+ T cells in autoimmune infiltrates in experimental allergic encephalomyelitis. International Immunology. 6: 347-354. PMID 7910482 DOI: 10.1093/Intimm/6.3.347  0.437
1994 Owens T, Renno T, Taupin V, Krakowski M. Inflammatory cytokines in the brain: does the CNS shape immune responses? Immunology Today. 15: 566-71. PMID 7848517 DOI: 10.1016/0167-5699(94)90218-6  0.426
1994 Poudrier J, Owens T. Co-stimulation by anti-immunoglobulin is required for B cell activation by CD40Llow T cells. European Journal of Immunology. 24: 2993-2999. PMID 7805727 DOI: 10.1002/Eji.1830241211  0.402
1994 Poudrier J, Owens T. CD54/intercellular adhesion molecule 1 and major histocompatibility complex II signaling induces B cells to express interleukin 2 receptors and complements help provided through CD40 ligation. Journal of Experimental Medicine. 179: 1417-1427. PMID 7513009 DOI: 10.1084/Jem.179.5.1417  0.353
1994 Taupin V, Renno T, Cashman N, Owens T. TNF production by an oligodendrocyte cell line Journal of Neuroimmunology. 54: 201. DOI: 10.1016/0165-5728(94)90555-X  0.312
1994 Renno T, Taupin V, Krakowski M, Sékaly R, Antel J, Owens T. Endothelial inflammation and EAE-like symptoms in mice transgenic for interferon-gamma (IFN-γ) in CNS Journal of Neuroimmunology. 54: 188. DOI: 10.1016/0165-5728(94)90478-2  0.379
1993 Zeine R, Heath D, Owens T. Enhanced response to antigen within lymph nodes of SJL/J mice that were protected against experimental allergic encephalomyelitis by T cell vaccination. Journal of Neuroimmunology. 44: 85-94. PMID 8496341 DOI: 10.1016/0165-5728(93)90271-Y  0.402
1993 Zeine R, Owens T. Loss rather than downregulation of CD4+ T cells as a mechanism for remission from experimental allergic encephalomyelitis Journal of Neuroimmunology. 44: 193-198. PMID 8099362 DOI: 10.1016/0165-5728(93)90042-W  0.432
1993 Renno T, Zeine R, Girard M, Owens T. CD4+ T cells and cytokines in murine EAE Journal of Neuroimmunology. 43: 210-211. DOI: 10.1016/0165-5728(93)90122-F  0.395
1992 Zeine R, Owens T. Direct demonstration of the infiltration of murine central nervous system by Pgp-1/CD44high CD45RBlow CD4+ T cells that induce experimental allergic encephalomyelitis Journal of Neuroimmunology. 40: 57-69. PMID 1381382 DOI: 10.1016/0165-5728(92)90213-5  0.407
1991 Owens T. Requirement for noncognate interaction with T cells for the activation of B cell immunoglobulin secretion by IL-2. Cellular Immunology. 133: 352-366. PMID 1826636 DOI: 10.1016/0008-8749(91)90110-W  0.379
1991 Owens T. A Role For Adhesion Molecules In Contact-Dependent T Help For B Cells European Journal of Immunology. 21: 979-983. PMID 1673435 DOI: 10.1002/Eji.1830210418  0.419
1989 Williamson DJ, Owens T, Pearse M. Detection of colony-stimulating factor messenger RNA in single T cells by in situ hybridization. Journal of Cellular Physiology. 139: 245-52. PMID 2785523 DOI: 10.1002/Jcp.1041390205  0.355
1989 Owens T, Zeine R. The cell biology of T-dependent B cell activation. Biochemistry and Cell Biology. 67: 481-489. PMID 2679797 DOI: 10.1139/O89-078  0.392
1988 Riedel C, Owens T, Nossal GJV. A significant proportion of normal resting B cells are induced to secrete immunoglobulin through contact with anti-receptor antibody-activated helper T cells in clonal cultures. European Journal of Immunology. 18: 403-408. PMID 2965647 DOI: 10.1002/Eji.1830180313  0.375
1988 Owens T. A noncognate interaction with anti-receptor antibody-activated helper T cells induces small resting murine B cells to proliferate and to secrete antibody European Journal of Immunology. 18: 395-401. PMID 2965646 DOI: 10.1002/Eji.1830180312  0.352
1988 Kelso A, Owens T. The role of CD4 in antigen-independent activation of isolated single T lymphocytes☆ Cellular Immunology. 116: 99-111. PMID 2901916 DOI: 10.1016/0008-8749(88)90213-4  0.37
1987 Owens T, Groth BFDS, Miller JFAP. Coaggregation of the T-cell receptor with CD4 and other T-cell surface molecules enhances T-cell activation. Proceedings of the National Academy of Sciences of the United States of America. 84: 9209-9213. PMID 3501123 DOI: 10.1073/Pnas.84.24.9209  0.381
1985 Crispe IN, Owens T. Veto in vivo Immunology Today. 6: 40-41. PMID 25291389 DOI: 10.1016/0167-5699(85)90043-X  0.418
1985 Crispe IN, Owens T. Suppression induction in vivo by a T helper clone European Journal of Immunology. 15: 407-409. PMID 3157584 DOI: 10.1002/Eji.1830150419  0.417
1984 Owens T, Czitrom AA, Gascoigne NR, Crispe IN, Ratcliffe MJ, Lai PK, Mitchison NA. The presentation of cell surface alloantigens to T cells. Immunobiology. 168: 189-201. PMID 6241598 DOI: 10.1016/S0171-2985(84)80110-2  0.334
1984 Owens T. In vivo and in vitro requirements for T-cell activation: Concordance and contrasts Cellular Immunology. 89: 232-234. PMID 6237737 DOI: 10.1016/0008-8749(84)90213-2  0.347
1984 Lai PK, Owens T. Helper T cell lines to major and to minor histocompatibility antigens are equally effective in the regulation of B cell responses in vivo. Cellular Immunology. 85: 406-416. PMID 6143622 DOI: 10.1016/0008-8749(84)90254-5  0.362
1982 Owens T, Kaplan JG. T-dependent B-cell activation is signalled by an early increase in potassium influx. Immunobiology. 162: 277-287. PMID 6982221 DOI: 10.1016/S0171-2985(11)80007-0  0.391
1980 Owens T, Kaplan JG. Cell interactions in concanavalin A activated cation flux and DNA synthesis of mouse lymphocytes Biochemistry and Cell Biology. 58: 1314-1317. PMID 6971141 DOI: 10.1139/O80-178  0.376
1980 Owens T, Kaplan JG. Increased cationic fluxes in stimulated lymphocytes of the mouse: response of enriched B- and T-cell subpopulations to B- and T-cell mitogens. Biochemistry and Cell Biology. 58: 831-839. PMID 6970062 DOI: 10.1139/O80-116  0.336
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