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George M. Church - Publications

Affiliations: 
Genetics Harvard Medical School, Boston, MA, United States 
Area:
Computational Genetics
Website:
http://www.fas.harvard.edu/~biophys/George_Church.htm
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452 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Labade AS, Chiang ZD, Comenho C, Reginato PL, Payne AC, Earl AS, Shrestha R, Duarte FM, Habibi E, Zhang R, Church GM, Boyden ES, Chen F, Buenrostro JD. Expansion genome sequencing links nuclear abnormalities to hotspots of aberrant euchromatin repression. Biorxiv : the Preprint Server For Biology. PMID 39386718 DOI: 10.1101/2024.09.24.614614  0.32
2024 Liu W, Li Y, Patrinos GP, Xu S, Thong MK, Chen Z, Crawley FP, Li L, Ekmekci PE, Drmanac R, Cheong W, Benamouzig R, Nguyen Q, Volchkov P, Reichardt JKV, ... ... Church G, et al. The 1% gift to humanity: The Human Genome Project II. Cell Research. PMID 39261573 DOI: 10.1038/s41422-024-01026-y  0.303
2024 Kuru E, Rittichier J, de Puig H, Flores A, Rout S, Han I, Reese AE, Bartlett TM, De Moliner F, Bernier SG, Galpin JD, Marchand J, Bedell W, Robinson-McCarthy L, Ahern CA, ... ... Church GM, et al. Rapid discovery and evolution of nanosensors containing fluorogenic amino acids. Nature Communications. 15: 7531. PMID 39237489 DOI: 10.1038/s41467-024-50956-z  0.799
2024 Appleton E, Mehdipour N, Daifuku T, Briers D, Haghighi I, Moret M, Chao G, Wannier T, Chiappino-Pepe A, Huang J, Belta C, Church GM. Algorithms for Autonomous Formation of Multicellular Shapes from Single Cells. Acs Synthetic Biology. PMID 39194023 DOI: 10.1021/acssynbio.4c00037  0.784
2024 Wang Y, Liu X, Zeng Y, Saka SK, Xie W, Goldaracena I, Kohman RE, Yin P, Church GM. Multiplexed in situ protein imaging using DNA-barcoded antibodies with extended hybridization chain reactions. Nucleic Acids Research. PMID 38966983 DOI: 10.1093/nar/gkae592  0.736
2024 Nyerges A, Chiappino-Pepe A, Budnik B, Baas-Thomas M, Flynn R, Yan S, Ostrov N, Liu M, Wang M, Zheng Q, Hu F, Chen K, Rudolph A, Chen D, Ahn J, ... ... Church GM, et al. Synthetic genomes unveil the effects of synonymous recoding. Biorxiv : the Preprint Server For Biology. PMID 38915524 DOI: 10.1101/2024.06.16.599206  0.824
2024 Callisto A, Strutz J, Leeper K, Kalhor R, Church G, Tyo KEJ, Bhan N. Post-translation digital data encoding into the genomes of mammalian cell populations. Biorxiv : the Preprint Server For Biology. PMID 38765976 DOI: 10.1101/2024.05.12.591851  0.76
2024 Ulicevic J, Shao Z, Jasnovidova O, Bressin A, Gajos M, Ng AH, Annaldasula S, Meierhofer D, Church GM, Busskamp V, Mayer A. Uncovering the dynamics and consequences of RNA isoform changes during neuronal differentiation. Molecular Systems Biology. PMID 38755290 DOI: 10.1038/s44320-024-00039-4  0.646
2024 Zheng Z, Xu L, Dou H, Zhou Y, Feng X, He X, Tian Z, Song L, Gao Y, Mo G, Hu J, Zhao H, Wei H, Church GM, Yang L. Testing multiplexed anti-ASFV CRISPR-Cas9 in reducing African swine fever virus. Microbiology Spectrum. e0216423. PMID 38563791 DOI: 10.1128/spectrum.02164-23  0.436
2024 Smidler AL, Marrogi E, Kauffman J, Paton DG, Westervelt KA, Church GM, Esvelt KM, Shaw WR, Catteruccia F. CRISPR-mediated germline mutagenesis for genetic sterilization of Anopheles gambiae males. Scientific Reports. 14: 4057. PMID 38374393 DOI: 10.1038/s41598-024-54498-8  0.618
2024 Stein J, Ericsson M, Nofal M, Magni L, Aufmkolk S, McMillan RB, Breimann L, Herlihy CP, Lee SD, Willemin A, Wohlmann J, Arguedas-Jimenez L, Yin P, Pombo A, Church GM, et al. Cryosectioning-enabled super-resolution microscopy for studying nuclear architecture at the single protein level. Biorxiv : the Preprint Server For Biology. PMID 38370628 DOI: 10.1101/2024.02.05.576943  0.392
2024 Sengupta A, Bandyopadhyay A, Sarkar D, Hendry JI, Schubert MG, Liu D, Church GM, Maranas CD, Pakrasi HB. Genome streamlining to improve performance of a fast-growing cyanobacterium UTEX 2973. Mbio. e0353023. PMID 38358263 DOI: 10.1128/mbio.03530-23  0.306
2024 Baker D, Church G. Protein design meets biosecurity. Science (New York, N.Y.). 383: 349. PMID 38271530 DOI: 10.1126/science.ado1671  0.326
2023 Islam M, Yang Y, Simmons AJ, Shah VM, Pavan MK, Xu Y, Tasneem N, Chen Z, Trinh LT, Molina P, Ramirez-Solano MA, Sadien I, Dou J, Chen K, Magnuson MA, ... ... Church GM, et al. Temporal recording of mammalian development and precancer. Biorxiv : the Preprint Server For Biology. PMID 38187699 DOI: 10.1101/2023.12.18.572260  0.73
2023 Rudolph A, Nyerges A, Chiappino-Pepe A, Landon M, Baas-Thomas M, Church G. Strategies to identify and edit improvements in synthetic genome segments episomally. Nucleic Acids Research. PMID 37615546 DOI: 10.1093/nar/gkad692  0.79
2023 Chao G, Zukin S, Fortuna PRJ, Boettner B, Church GM. Progress and limitations in engineering cellular adhesion for research and therapeutics. Trends in Cell Biology. PMID 37580241 DOI: 10.1016/j.tcb.2023.07.007  0.751
2023 Smidler AL, Paton DG, Church GM, Esvelt KM, Shaw WR, Catteruccia F. CRISPR-mediated germline mutagenesis for genetic sterilization of males. Biorxiv : the Preprint Server For Biology. PMID 37398131 DOI: 10.1101/2023.06.13.544841  0.619
2023 Pierson Smela MD, Kramme CC, Fortuna PRJ, Adams JL, Su AR, Dong E, Kobayashi M, Brixi G, Kavirayuni VS, Tysinger E, Kohman RE, Shioda T, Chatterjee P, Church GM. Correction: Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression. Elife. 12. PMID 36947114 DOI: 10.7554/eLife.87987  0.679
2023 Nyerges A, Vinke S, Flynn R, Owen SV, Rand EA, Budnik B, Keen E, Narasimhan K, Marchand JA, Baas-Thomas M, Liu M, Chen K, Chiappino-Pepe A, Hu F, Baym M, ... Church GM, et al. A swapped genetic code prevents viral infections and gene transfer. Nature. PMID 36922599 DOI: 10.1038/s41586-023-05824-z  0.796
2023 Pierson Smela MD, Kramme CC, Fortuna PRJ, Adams JL, Su R, Dong E, Kobayashi M, Brixi G, Kavirayuni VS, Tysinger E, Kohman RE, Shioda T, Chatterjee P, Church GM. Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression. Elife. 12. PMID 36803359 DOI: 10.7554/eLife.83291  0.685
2023 Jo C, Zhang J, Tam JM, Church GM, Khalil AS, Segrè D, Tang TC. Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability. Materials Today. Bio. 19: 100560. PMID 36756210 DOI: 10.1016/j.mtbio.2023.100560  0.575
2022 Hyun I, Scharf-Deering JC, Sullivan S, Aach JD, Arlotta P, Baum ML, Church GM, Goldenberg A, Greely HT, Khoshakhlagh P, Kohman RE, Lopes M, Lowenthal C, Lu A, Ng AHM, et al. How collaboration between bioethicists and neuroscientists can advance research. Nature Neuroscience. PMID 36258039 DOI: 10.1038/s41593-022-01187-2  0.653
2022 Chao G, Wannier TM, Gutierrez C, Borders NC, Appleton E, Chadha A, Lebar T, Church GM. helixCAM: A platform for programmable cellular assembly in bacteria and human cells. Cell. 185: 3551-3567.e39. PMID 36055250 DOI: 10.1016/j.cell.2022.08.012  0.748
2022 Chen Y, Hysolli E, Chen A, Casper S, Liu S, Yang K, Liu C, Church G. Multiplex base editing to convert TAG into TAA codons in the human genome. Nature Communications. 13: 4482. PMID 35918324 DOI: 10.1038/s41467-022-31927-8  0.317
2022 Bhattarai-Kline S, Lear SK, Fishman CB, Lopez SC, Lockshin ER, Schubert MG, Nivala J, Church GM, Shipman SL. Recording gene expression order in DNA by CRISPR addition of retron barcodes. Nature. 608: 217-225. PMID 35896746 DOI: 10.1038/s41586-022-04994-6  0.815
2022 Baas-Thomas MS, Oehm SB, Ostrov N, Church GM. Characterization of ColE1 Production for Robust Plate Dual-Selection in . Acs Synthetic Biology. PMID 35666547 DOI: 10.1021/acssynbio.2c00061  0.772
2022 Kobayashi M, Kobayashi M, Odajima J, Shioda K, Hwang YS, Sasaki K, Chatterjee P, Kramme C, Kohman RE, Church GM, Loehr AR, Weiss RS, Jüppner H, Gell JJ, Lau CC, et al. Expanding homogeneous culture of human primordial germ cell-like cells maintaining germline features without serum or feeder layers. Stem Cell Reports. PMID 35148847 DOI: 10.1016/j.stemcr.2022.01.012  0.68
2021 Wannier TM, Ciaccia PN, Ellington AD, Filsinger GT, Isaacs FJ, Javanmardi K, Jones MA, Kunjapur AM, Nyerges A, Pal C, Schubert MG, Church GM. Recombineering and MAGE. Nature Reviews. Methods Primers. 1. PMID 35540496 DOI: 10.1038/s43586-020-00006-x  0.687
2021 Kramme C, Plesa AM, Wang HH, Wolf B, Smela MP, Guo X, Kohman RE, Chatterjee P, Church GM. An integrated pipeline for mammalian genetic screening. Cell Reports Methods. 1: 100082. PMID 35474898 DOI: 10.1016/j.crmeth.2021.100082  0.725
2021 Kramme C, Plesa AM, Wang HH, Wolf B, Smela MP, Guo X, Kohman RE, Chatterjee P, Church GM. MegaGate: A toxin-less gateway molecular cloning tool. Star Protocols. 2: 100907. PMID 34746865 DOI: 10.1016/j.xpro.2021.100907  0.694
2021 Liu S, Striebel J, Pasquini G, Ng AHM, Khoshakhlagh P, Church GM, Busskamp V. Neuronal Cell-type Engineering by Transcriptional Activation. Frontiers in Genome Editing. 3: 715697. PMID 34713262 DOI: 10.3389/fgeed.2021.715697  0.634
2021 Bhan N, Callisto A, Strutz J, Glaser J, Kalhor R, Boyden ES, Church G, Kording K, Tyo KEJ. Recording Temporal Signals with Minutes Resolution Using Enzymatic DNA Synthesis. Journal of the American Chemical Society. 143: 16630-16640. PMID 34591459 DOI: 10.1021/jacs.1c07331  0.727
2021 Robinson-McCarthy LR, Mijalis AJ, Filsinger GT, de Puig H, Donghia NM, Schaus TE, Rasmussen RA, Ferreira R, Lunshof JE, Chao G, Ter-Ovanesyan D, Dodd O, Kuru E, Sesay AM, Rainbow J, ... ... Church GM, et al. Laboratory-Generated DNA Can Cause Anomalous Pathogen Diagnostic Test Results. Microbiology Spectrum. e0031321. PMID 34523989 DOI: 10.1128/Spectrum.00313-21  0.774
2021 Bosley K, Casebourn C, Chan P, Chen J, Chen M, Church G, Cumbers J, de Wouters T, Dewey-Hagborg H, Duportet X, Ene-Obong A, Elizondo A, Farrar J, Gates B, Gatto F, et al. Publisher Correction: Voices of biotech leaders. Nature Biotechnology. PMID 34290438 DOI: 10.1038/s41587-021-01000-8  0.325
2021 Abong AE, Bosley K, Casebourn C, Chan P, Chen J, Chen M, Church G, Cumbers J, de Wouters T, Dewey-Hagborg H, Duportet X, Elizondo A, Farrar J, Gates B, Gatto F, et al. Voices of biotech leaders. Nature Biotechnology. 39: 654-660. PMID 34113035 DOI: 10.1038/s41587-021-00941-4  0.318
2021 Yang L, Church G, Zhao HY, Huang L, Gao Y, Wei HJ, Yang G. Porcine germline genome engineering. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34050015 DOI: 10.1073/pnas.2004836117  0.457
2021 Chao G, Travis C, Church G. Measurement of Large Serine Integrase Enzymatic Characteristics in HEK293 Cells Reveals Variability and Influence on Downstream Reporter Expression. The Febs Journal. PMID 34043859 DOI: 10.1111/febs.16037  0.763
2021 Schubert MG, Goodman DB, Wannier TM, Kaur D, Farzadfard F, Lu TK, Shipman SL, Church GM. High-throughput functional variant screens via in vivo production of single-stranded DNA. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33906944 DOI: 10.1073/pnas.2018181118  0.825
2021 Biswas S, Khimulya G, Alley EC, Esvelt KM, Church GM. Low-N protein engineering with data-efficient deep learning. Nature Methods. 18: 389-396. PMID 33828272 DOI: 10.1038/s41592-021-01100-y  0.656
2021 Liu S, Punthambaker S, Iyer EPR, Ferrante T, Goodwin D, Fürth D, Pawlowski AC, Jindal K, Tam JM, Mifflin L, Alon S, Sinha A, Wassie AT, Chen F, Cheng A, ... ... Church GM, et al. Barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel in situ analyses. Nucleic Acids Research. PMID 33693773 DOI: 10.1093/nar/gkab120  0.802
2021 Leeper K, Kalhor K, Vernet A, Graveline A, Church GM, Mali P, Kalhor R. Lineage barcoding in mice with homing CRISPR. Nature Protocols. PMID 33692551 DOI: 10.1038/s41596-020-00485-y  0.799
2021 Alon S, Goodwin DR, Sinha A, Wassie AT, Chen F, Daugharthy ER, Bando Y, Kajita A, Xue AG, Marrett K, Prior R, Cui Y, Payne AC, Yao CC, Suk HJ, ... ... Church GM, et al. Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems. Science (New York, N.Y.). 371. PMID 33509999 DOI: 10.1126/science.aax2656  0.796
2021 Filsinger GT, Wannier TM, Pedersen FB, Lutz ID, Zhang J, Stork DA, Debnath A, Gozzi K, Kuchwara H, Volf V, Wang S, Rios X, Gregg CJ, Lajoie MJ, Shipman SL, ... ... Church GM, et al. Characterizing the portability of phage-encoded homologous recombination proteins. Nature Chemical Biology. PMID 33462496 DOI: 10.1038/s41589-020-00710-5  0.817
2021 Robinson-McCarthy LR, Mijalis AJ, Filsinger GT, de Puig H, Donghia NM, Schaus TE, Rasmussen RA, Ferreira R, Lunshof JE, Chao G, Ter-Ovanesyan D, Dodd O, Kuru E, Sesay AM, Rainbow J, ... ... Church GM, et al. Anomalous COVID-19 tests hinder researchers. Science (New York, N.Y.). 371: 244-245. PMID 33446547 DOI: 10.1126/science.abf8873  0.753
2020 DeLisi C, Patrinos A, MacCracken M, Drell D, Annas G, Arkin A, Church G, Cook-Deegan R, Jacoby H, Lidstrom M, Melillo J, Milo R, Paustian K, Reilly J, Roberts RJ, et al. The Role of Synthetic Biology in Atmospheric Greenhouse Gas Reduction: Prospects and Challenges. Biodesign Research. 2020: 1016207. PMID 37849905 DOI: 10.34133/2020/1016207  0.659
2020 Payne AC, Chiang ZD, Reginato PL, Mangiameli SM, Murray EM, Yao CC, Markoulaki S, Earl AS, Labade AS, Jaenisch R, Church GM, Boyden ES, Buenrostro JD, Chen F. In situ genome sequencing resolves DNA sequence and structure in intact biological samples. Science (New York, N.Y.). PMID 33384301 DOI: 10.1126/science.aay3446  0.317
2020 Palla M, Punthambaker S, Stranges B, Vigneault F, Nivala J, Wiegand D, Ayer A, Craig T, Gremyachinskiy D, Franklin H, Sun S, Pollard J, Trans A, Arnold C, Schwab C, ... ... Church GM, et al. Multiplex Single-Molecule Kinetics of Nanopore-Coupled Polymerases. Acs Nano. PMID 33370106 DOI: 10.1021/acsnano.0c05226  0.735
2020 Estep PW, Church GM. Transparency is key to ethical vaccine research. Science (New York, N.Y.). 370: 1422-1423. PMID 33335056 DOI: 10.1126/science.abf4851  0.719
2020 Long KC, Alphey L, Annas GJ, Bloss CS, Campbell KJ, Champer J, Chen CH, Choudhary A, Church GM, Collins JP, Cooper KL, Delborne JA, Edwards OR, Emerson CI, Esvelt K, et al. Core commitments for field trials of gene drive organisms. Science (New York, N.Y.). 370: 1417-1419. PMID 33335055 DOI: 10.1126/science.abd1908  0.602
2020 Lewis G, Jordan JL, Relman DA, Koblentz GD, Leung J, Dafoe A, Nelson C, Epstein GL, Katz R, Montague M, Alley EC, Filone CM, Luby S, Church GM, Millett P, et al. The biosecurity benefits of genetic engineering attribution. Nature Communications. 11: 6294. PMID 33293537 DOI: 10.1038/s41467-020-19149-2  0.643
2020 Alley EC, Turpin M, Liu AB, Kulp-McDowall T, Swett J, Edison R, Von Stetina SE, Church GM, Esvelt KM. A machine learning toolkit for genetic engineering attribution to facilitate biosecurity. Nature Communications. 11: 6293. PMID 33293535 DOI: 10.1038/s41467-020-19612-0  0.632
2020 Ng AHM, Khoshakhlagh P, Rojo Arias JE, Pasquini G, Wang K, Swiersy A, Shipman SL, Appleton E, Kiaee K, Kohman RE, Vernet A, Dysart M, Leeper K, Saylor W, Huang JY, ... ... Church GM, et al. A comprehensive library of human transcription factors for cell fate engineering. Nature Biotechnology. PMID 33257861 DOI: 10.1038/s41587-020-0742-6  0.787
2020 Angrist M, Barrangou R, Baylis F, Brokowski C, Burgio G, Caplan A, Chapman CR, Church GM, Cook-Deegan R, Cwik B, Doudna JA, Evans JH, Greely HT, Hercher L, Hurlbut JB, et al. Reactions to the National Academies/Royal Society Report on . The Crispr Journal. 3: 332-349. PMID 33095048 DOI: 10.1089/crispr.2020.29106.man  0.459
2020 Lee H, Wiegand DJ, Griswold K, Punthambaker S, Chun H, Kohman RE, Church GM. Photon-directed multiplexed enzymatic DNA synthesis for molecular digital data storage. Nature Communications. 11: 5246. PMID 33067441 DOI: 10.1038/s41467-020-18681-5  0.709
2020 Angenent-Mari NM, Garruss AS, Soenksen LR, Church G, Collins JJ. A deep learning approach to programmable RNA switches. Nature Communications. 11: 5057. PMID 33028812 DOI: 10.1038/s41467-020-18677-1  0.393
2020 Yue Y, Xu W, Kan Y, Zhao HY, Zhou Y, Song X, Wu J, Xiong J, Goswami D, Yang M, Lamriben L, Xu M, Zhang Q, Luo Y, Guo J, ... ... Church GM, et al. Extensive germline genome engineering in pigs. Nature Biomedical Engineering. PMID 32958897 DOI: 10.1038/S41551-020-00613-9  0.539
2020 Dryzek JS, Nicol D, Niemeyer S, Pemberton S, Curato N, Bächtiger A, Batterham P, Bedsted B, Burall S, Burgess M, Burgio G, Castelfranchi Y, Chneiweiss H, Church G, Crossley M, et al. Global citizen deliberation on genome editing. Science (New York, N.Y.). 369: 1435-1437. PMID 32943515 DOI: 10.1126/Science.Abb5931  0.371
2020 Marchand JA, Pierson Smela MD, Jordan THH, Narasimhan K, Church GM. TBDB: a database of structurally annotated T-box riboswitch:tRNA pairs. Nucleic Acids Research. PMID 32882008 DOI: 10.1093/Nar/Gkaa721  0.793
2020 MacKay MJ, Hooker AC, Afshinnekoo E, Salit M, Kelly J, Feldstein JV, Haft N, Schenkel D, Nambi S, Cai Y, Zhang F, Church G, Dai J, Wang CL, Levy S, et al. The COVID-19 XPRIZE and the need for scalable, fast, and widespread testing. Nature Biotechnology. PMID 32820257 DOI: 10.1038/S41587-020-0655-4  0.351
2020 Jeon S, Bhak Y, Choi Y, Jeon Y, Kim S, Jang J, Jang J, Blazyte A, Kim C, Kim Y, Shim J, Kim N, Kim YJ, Park SG, Kim J, ... ... Church G, et al. Korean Genome Project: 1094 Korean personal genomes with clinical information. Science Advances. 6: eaaz7835. PMID 32766443 DOI: 10.1126/Sciadv.Aaz7835  0.399
2020 Weber JA, Park SG, Luria V, Jeon S, Kim HM, Jeon Y, Bhak Y, Jun JH, Kim SW, Hong WH, Lee S, Cho YS, Karger A, Cain JW, Manica A, ... ... Church GM, et al. The whale shark genome reveals how genomic and physiological properties scale with body size. Proceedings of the National Academy of Sciences of the United States of America. PMID 32753383 DOI: 10.1073/Pnas.1922576117  0.406
2020 Nguyen HQ, Chattoraj S, Castillo D, Nguyen SC, Nir G, Lioutas A, Hershberg EA, Martins NMC, Reginato PL, Hannan M, Beliveau BJ, Church GM, Daugharthy ER, Marti-Renom MA, Wu CT. 3D mapping and accelerated super-resolution imaging of the human genome using in situ sequencing. Nature Methods. PMID 32719531 DOI: 10.1038/S41592-020-0890-0  0.384
2020 Zook JM, Hansen NF, Olson ND, Chapman L, Mullikin JC, Xiao C, Sherry S, Koren S, Phillippy AM, Boutros PC, Sahraeian SME, Huang V, Rouette A, Alexander N, Mason CE, ... ... Church G, et al. A robust benchmark for detection of germline large deletions and insertions. Nature Biotechnology. PMID 32541955 DOI: 10.1038/S41587-020-0538-8  0.418
2020 Wannier TM, Nyerges A, Kuchwara HM, Czikkely M, Balogh D, Filsinger GT, Borders NC, Gregg CJ, Lajoie MJ, Rios X, Pál C, Church GM. Improved bacterial recombineering by parallelized protein discovery. Proceedings of the National Academy of Sciences of the United States of America. PMID 32467157 DOI: 10.1073/Pnas.2001588117  0.762
2020 Turczyk BM, Busby M, Martin AL, Daugharthy ER, Myung D, Terry RC, Inverso SA, Kohman RE, Church GM. Spatial Sequencing: A Perspective. Journal of Biomolecular Techniques : Jbt. PMID 32382252 DOI: 10.7171/Jbt.20-3102-003  0.73
2020 Smith CJ, Castanon O, Said K, Volf V, Khoshakhlagh P, Hornick A, Ferreira R, Wu CT, Güell M, Garg S, Ng AHM, Myllykallio H, Church GM. Enabling large-scale genome editing at repetitive elements by reducing DNA nicking. Nucleic Acids Research. PMID 32315033 DOI: 10.1093/Nar/Gkaa239  0.417
2020 Stokes JM, Yang K, Swanson K, Jin W, Cubillos-Ruiz A, Donghia NM, MacNair CR, French S, Carfrae LA, Bloom-Ackermann Z, Tran VM, Chiappino-Pepe A, Badran AH, Andrews IW, Chory EJ, ... Church GM, et al. A Deep Learning Approach to Antibiotic Discovery. Cell. 181: 475-483. PMID 32302574 DOI: 10.1016/j.cell.2020.04.001  0.756
2020 Niu D, Ma X, Yuan T, Niu Y, Xu Y, Sun Z, Ping Y, Li W, Zhang J, Wang T, Church GM. Porcine genome engineering for xenotransplantation. Advanced Drug Delivery Reviews. PMID 32275950 DOI: 10.1016/J.Addr.2020.04.001  0.333
2020 Stokes JM, Yang K, Swanson K, Jin W, Cubillos-Ruiz A, Donghia NM, MacNair CR, French S, Carfrae LA, Bloom-Ackerman Z, Tran VM, Chiappino-Pepe A, Badran AH, Andrews IW, Chory EJ, ... Church GM, et al. A Deep Learning Approach to Antibiotic Discovery. Cell. 180: 688-702.e13. PMID 32084340 DOI: 10.1016/J.Cell.2020.01.021  0.772
2019 Garg S, Aach J, Li H, Durbin R, Church G. A haplotype-aware de novo assembly of related individuals using pedigree sequence graph. Bioinformatics (Oxford, England). PMID 31860070 DOI: 10.1093/Bioinformatics/Btz942  0.396
2019 Ogden PJ, Kelsic ED, Sinai S, Church GM. Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design. Science (New York, N.Y.). 366: 1139-1143. PMID 31780559 DOI: 10.1126/Science.Aaw2900  0.372
2019 Kalhor K, Church GM. Single-Cell CRISPR-Based Lineage Tracing in Mice. Biochemistry. PMID 31730337 DOI: 10.1021/Acs.Biochem.9B00688  0.768
2019 Minev D, Guerra R, Kishi JY, Smith C, Krieg E, Said K, Hornick A, Sasaki HM, Filsinger G, Beliveau BJ, Yin P, Church GM, Shih WM. Rapid in vitro production of single-stranded DNA. Nucleic Acids Research. PMID 31713635 DOI: 10.1093/Nar/Gkz998  0.672
2019 Alley EC, Khimulya G, Biswas S, AlQuraishi M, Church GM. Unified rational protein engineering with sequence-based deep representation learning. Nature Methods. PMID 31636460 DOI: 10.1038/S41592-019-0598-1  0.312
2019 Ostrov N, Beal J, Ellis T, Gordon DB, Karas BJ, Lee HH, Lenaghan SC, Schloss JA, Stracquadanio G, Trefzer A, Bader JS, Church GM, Coelho CM, Efcavitch JW, Güell M, et al. Technological challenges and milestones for writing genomes. Science (New York, N.Y.). 366: 310-312. PMID 31624201 DOI: 10.1126/Science.Aay0339  0.79
2019 Grishin D, Obbad K, Church GM. Data privacy in the age of personal genomics. Nature Biotechnology. 37: 1115-1117. PMID 31537915 DOI: 10.1038/S41587-019-0271-3  0.314
2019 Saka SK, Wang Y, Kishi JY, Zhu A, Zeng Y, Xie W, Kirli K, Yapp C, Cicconet M, Beliveau BJ, Lapan SW, Yin S, Lin M, Boyden ES, Kaeser PS, ... ... Church GM, et al. Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues. Nature Biotechnology. PMID 31427819 DOI: 10.1038/S41587-019-0207-Y  0.468
2019 Lee HH, Kalhor R, Goela N, Bolot J, Church GM. Terminator-free template-independent enzymatic DNA synthesis for digital information storage. Nature Communications. 10: 2383. PMID 31160595 DOI: 10.1038/S41467-019-10258-1  0.75
2019 Lee HH, Ostrov N, Wong BG, Gold MA, Khalil AS, Church GM. Functional genomics of the rapidly replicating bacterium Vibrio natriegens by CRISPRi. Nature Microbiology. PMID 30962569 DOI: 10.1038/S41564-019-0423-8  0.81
2019 Shendure J, Balasubramanian S, Church GM, Gilbert W, Rogers J, Schloss JA, Waterston RH. Publisher Correction: DNA sequencing at 40: past, present and future. Nature. PMID 30948799 DOI: 10.1038/S41586-019-1120-8  0.62
2019 Noble C, Min J, Olejarz J, Buchthal J, Chavez A, Smidler AL, DeBenedictis EA, Church GM, Nowak MA, Esvelt KM. Daisy-chain gene drives for the alteration of local populations. Proceedings of the National Academy of Sciences of the United States of America. PMID 30940750 DOI: 10.1073/Pnas.1716358116  0.791
2019 Wiegand DJ, Lee HH, Ostrov N, Church GM. Cell-free Protein Expression Using the Rapidly Growing Bacterium Vibrio natriegens. Journal of Visualized Experiments : Jove. PMID 30933074 DOI: 10.3791/59495  0.769
2019 Labun K, Guo X, Chavez A, Church G, Gagnon JA, Valen E. Accurate analysis of genuine CRISPR editing events with ampliCan. Genome Research. PMID 30850374 DOI: 10.1101/Gr.244293.118  0.396
2019 Zoltick ES, Linderman MD, McGinniss MA, Ramos E, Ball MP, Church GM, Leonard DGB, Pereira S, McGuire AL, Caskey CT, Sanderson SC, Schadt EE, Nielsen DE, Crawford SD, Green RC, et al. Predispositional genome sequencing in healthy adults: design, participant characteristics, and early outcomes of the PeopleSeq Consortium. Genome Medicine. 11: 10. PMID 30808425 DOI: 10.1186/S13073-019-0619-9  0.367
2019 Hoehe MR, Herwig R, Mao Q, Peters BA, Drmanac R, Church GM, Huebsch T. Significant abundance of cis configurations of coding variants in diploid human genomes. Nucleic Acids Research. PMID 30698752 DOI: 10.1093/Nar/Gkz031  0.377
2019 Caldwell BJ, Zakharova E, Filsinger GT, Wannier TM, Hempfling JP, Chun-Der L, Pei D, Church GM, Bell CE. Crystal structure of the Red beta C-terminal domain in complex with lambda Exonuclease reveals an unexpected homology with lambda Orf and an interaction with Escherichia coli single stranded DNA binding protein. Nucleic Acids Research. 47: 1950-1963. DOI: 10.2210/Pdb6M9K/Pdb  0.309
2019 Wan T, Niu D, Wu C, Xu F, Church G, Ping Y. Material solutions for delivery of CRISPR/Cas-based genome editing tools: Current status and future outlook Materials Today. 26: 40-66. DOI: 10.1016/J.Mattod.2018.12.003  0.381
2018 Møller HD, Lin L, Xiang X, Petersen TS, Huang J, Yang L, Kjeldsen E, Jensen UB, Zhang X, Liu X, Xu X, Wang J, Yang H, Church GM, Bolund L, et al. CRISPR-C: circularization of genes and chromosome by CRISPR in human cells. Nucleic Acids Research. 46: e131. PMID 30551175 DOI: 10.1093/Nar/Gky767  0.552
2018 Nageshwaran S, Chavez A, Cher Yeo N, Guo X, Lance-Byrne A, Tung A, Collins JJ, Church GM. CRISPR Guide RNA Cloning for Mammalian Systems. Journal of Visualized Experiments : Jove. PMID 30346403 DOI: 10.3791/57998  0.477
2018 Brunk E, Chang RL, Xia J, Hefzi H, Yurkovich JT, Kim D, Buckmiller E, Wang HH, Cho BK, Yang C, Palsson BO, Church GM, Lewis NE. Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow. Proceedings of the National Academy of Sciences of the United States of America. PMID 30301795 DOI: 10.1073/Pnas.1811971115  0.796
2018 Wiegand D, Lee HH, Ostrov N, Church GM. Establishing a cell-free Vibrio natriegens expression system. Acs Synthetic Biology. PMID 30160938 DOI: 10.1021/Acssynbio.8B00222  0.773
2018 Kalhor R, Kalhor K, Mejia L, Leeper K, Graveline A, Mali P, Church GM. Developmental barcoding of whole mouse via homing CRISPR. Science (New York, N.Y.). PMID 30093604 DOI: 10.1126/Science.Aat9804  0.785
2018 Juárez JF, Lecube-Azpeitia B, Brown SL, Johnston CD, Church GM. Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators. Nature Communications. 9: 3101. PMID 30082754 DOI: 10.1038/S41467-018-05525-6  0.317
2018 Yeo NC, Chavez A, Lance-Byrne A, Chan Y, Menn D, Milanova D, Kuo CC, Guo X, Sharma S, Tung A, Cecchi RJ, Tuttle M, Pradhan S, Lim ET, Davidsohn N, ... ... Church GM, et al. An enhanced CRISPR repressor for targeted mammalian gene regulation. Nature Methods. PMID 30013045 DOI: 10.1038/S41592-018-0048-5  0.638
2018 Musah S, Dimitrakakis N, Camacho DM, Church GM, Ingber DE. Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip. Nature Protocols. 13: 1662-1685. PMID 29995874 DOI: 10.1038/S41596-018-0007-8  0.743
2018 Clarke R, Heler R, MacDougall MS, Yeo NC, Chavez A, Regan M, Hanakahi L, Church GM, Marraffini LA, Merrill BJ. Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks. Molecular Cell. 71: 42-55.e8. PMID 29979968 DOI: 10.1016/J.Molcel.2018.06.005  0.424
2018 Noble C, Adlam B, Church GM, Esvelt KM, Nowak MA. Current CRISPR gene drive systems are likely to be highly invasive in wild populations. Elife. 7. PMID 29916367 DOI: 10.7554/Elife.33423  0.65
2018 Saha K, Hurlbut JB, Jasanoff S, Ahmed A, Appiah A, Bartholet E, Baylis F, Bennett G, Church G, Cohen IG, Daley G, Finneran K, Hurlbut W, Jaenisch R, Lwoff L, et al. Building Capacity for a Global Genome Editing Observatory: Institutional Design. Trends in Biotechnology. PMID 29891181 DOI: 10.1016/J.Tibtech.2018.04.008  0.353
2018 Hurlbut JB, Jasanoff S, Saha K, Ahmed A, Appiah A, Bartholet E, Baylis F, Bennett G, Church G, Cohen IG, Daley G, Finneran K, Hurlbut W, Jaenisch R, Lwoff L, et al. Building Capacity for a Global Genome Editing Observatory: Conceptual Challenges. Trends in Biotechnology. PMID 29871776 DOI: 10.1016/J.Tibtech.2018.04.009  0.352
2018 Guo X, Chavez A, Tung A, Chan Y, Kaas C, Yin Y, Cecchi R, Garnier SL, Kelsic ED, Schubert M, DiCarlo JE, Collins JJ, Church GM. High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR-Cas9 in yeast. Nature Biotechnology. PMID 29786095 DOI: 10.1038/Nbt.4147  0.833
2018 Frumkin I, Lajoie MJ, Gregg CJ, Hornung G, Church GM, Pilpel Y. Codon usage of highly expressed genes affects proteome-wide translation efficiency. Proceedings of the National Academy of Sciences of the United States of America. PMID 29735666 DOI: 10.1073/Pnas.1719375115  0.73
2018 de Paz AM, Cybulski TR, Marblestone AH, Zamft BM, Church GM, Boyden ES, Kording KP, Tyo KEJ. High-resolution mapping of DNA polymerase fidelity using nucleotide imbalances and next-generation sequencing. Nucleic Acids Research. PMID 29718339 DOI: 10.1093/Nar/Gky296  0.737
2018 Farahany NA, Greely HT, Hyman S, Koch C, Grady C, Pașca SP, Sestan N, Arlotta P, Bernat JL, Ting J, Lunshof JE, Iyer EPR, Hyun I, Capestany BH, Church GM, et al. The ethics of experimenting with human brain tissue. Nature. 556: 429-432. PMID 29691509 DOI: 10.1038/D41586-018-04813-X  0.753
2018 Bester AC, Lee JD, Chavez A, Lee YR, Nachmani D, Vora S, Victor J, Sauvageau M, Monteleone E, Rinn JL, Provero P, Church GM, Clohessy JG, Pandolfi PP. An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance. Cell. 173: 649-664.e20. PMID 29677511 DOI: 10.1016/J.Cell.2018.03.052  0.435
2018 Chan Y, Chan YK, Goodman DB, Guo X, Chavez A, Lim ET, Church GM. Enabling multiplexed testing of pooled donor cells through whole-genome sequencing. Genome Medicine. 10: 31. PMID 29673390 DOI: 10.1186/S13073-018-0541-6  0.688
2018 Chavez A, Pruitt BW, Tuttle M, Shapiro RS, Cecchi RJ, Winston J, Turczyk BM, Tung M, Collins JJ, Church GM. Precise Cas9 targeting enables genomic mutation prevention. Proceedings of the National Academy of Sciences of the United States of America. PMID 29555762 DOI: 10.1073/Pnas.1718148115  0.481
2018 Wannier TM, Kunjapur AM, Rice DP, McDonald MJ, Desai MM, Church GM. Adaptive evolution of genomically recoded. Proceedings of the National Academy of Sciences of the United States of America. PMID 29440500 DOI: 10.1073/Pnas.1715530115  0.401
2018 Nivala J, Shipman SL, Church GM. Spontaneous CRISPR loci generation in vivo by non-canonical spacer integration. Nature Microbiology. PMID 29379209 DOI: 10.1038/S41564-017-0097-Z  0.808
2018 Kohman RE, Kunjapur AM, Hysolli E, Wang Y, Church GM. From Designing the Molecules of Life to Designing Life: Future Applications Derived from Advances in DNA Technologies. Angewandte Chemie (International Ed. in English). PMID 29316123 DOI: 10.1002/Anie.201707976  0.759
2018 Kunjapur AM, Stork DA, Kuru E, Vargas-Rodriguez O, Landon M, Söll D, Church GM. Engineering posttranslational proofreading to discriminate nonstandard amino acids. Proceedings of the National Academy of Sciences of the United States of America. PMID 29301968 DOI: 10.1073/Pnas.1715137115  0.304
2018 Noble C, Adlam B, Church GM, Esvelt KM, Nowak MA. Author response: Current CRISPR gene drive systems are likely to be highly invasive in wild populations Elife. DOI: 10.7554/Elife.33423.021  0.64
2018 Grishin D, Obbad K, Estep P, Quinn K, Zaranek SW, Zaranek AW, Vandewege W, Clegg T, César N, Cifric M, Church G. Accelerating Genomic Data Generation and Facilitating Genomic Data Access Using Decentralization, Privacy-Preserving Technologies and Equitable Compensation Blockchain in Healthcare Today. 1: 1-23. DOI: 10.30953/BHTY.V1.34  0.767
2018 Kohman RE, Kunjapur AM, Hysolli E, Wang Y, Church GM. Vom Design der Moleküle des Lebens zum Design von Leben: Zukünftige Anwendungen von DNA-Technologien Angewandte Chemie. 130: 4395-4411. DOI: 10.1002/Ange.201707976  0.701
2017 Thompson DB, Aboulhouda S, Hysolli E, Smith CJ, Wang S, Castanon O, Church GM. The future of multiplexed eukaryotic genome engineering. Acs Chemical Biology. PMID 29241002 DOI: 10.1021/Acschembio.7B00842  0.421
2017 Chen X, Sun YC, Church GM, Lee JH, Zador AM. Efficient in situ barcode sequencing using padlock probe-based BaristaSeq. Nucleic Acids Research. PMID 29190363 DOI: 10.1093/Nar/Gkx1206  0.429
2017 Güell M, Niu D, Kan Y, George H, Wang T, Lee IH, Wang G, Church G, Yang L. PERV inactivation is necessary to guarantee absence of pig-to-patient PERVs transmission in xenotransplantation. Xenotransplantation. PMID 29171094 DOI: 10.1111/Xen.12366  0.407
2017 Shapiro RS, Chavez A, Porter CBM, Hamblin M, Kaas CS, DiCarlo JE, Zeng G, Xu X, Revtovich AV, Kirienko NV, Wang Y, Church GM, Collins JJ. A CRISPR-Cas9-based gene drive platform for genetic interaction analysis in Candida albicans. Nature Microbiology. PMID 29062088 DOI: 10.1038/S41564-017-0043-0  0.789
2017 Musah S, Mammoto A, Ferrante TC, Jeanty SSF, Hirano-Kobayashi M, Mammoto T, Roberts K, Chung S, Novak R, Ingram M, Fatanat-Didar T, Koshy S, Weaver JC, Church GM, Ingber DE. Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip. Nature Biomedical Engineering. 1. PMID 29038743 DOI: 10.1038/S41551-017-0069  0.742
2017 Shendure J, Balasubramanian S, Church GM, Gilbert W, Rogers J, Schloss JA, Waterston RH. DNA sequencing at 40: past, present and future. Nature. PMID 29019985 DOI: 10.1038/Nature24286  0.675
2017 Yang L, Briggs AW, Chew WL, Mali P, Guell M, Aach J, Goodman DB, Cox D, Kan Y, Lesha E, Soundararajan V, Zhang F, Church G. Corrigendum: Engineering and optimising deaminase fusions for genome editing. Nature Communications. 8: 16169. PMID 28991237 DOI: 10.1038/Ncomms16169  0.799
2017 Cho YS, Kim H, Kim HM, Jho S, Jun J, Lee YJ, Chae KS, Kim CG, Kim S, Eriksson A, Edwards JS, Lee S, Kim BC, Manica A, Oh TK, ... Church GM, et al. Corrigendum: An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes. Nature Communications. 8: 16168. PMID 28991236 DOI: 10.1038/Ncomms16168  0.363
2017 Fang L, Guell M, Church GM, Pfeifer BA. Heterologous Erythromycin Production across Strain and Plasmid Construction. Biotechnology Progress. PMID 28960932 DOI: 10.1002/Btpr.2567  0.326
2017 Wang Y, Woehrstein JB, Donoghue N, Dai M, Avendano MS, Schackmann RCJ, Zoeller J, Wang SSH, Tillberg PW, Park D, Lapan SW, Boyden ES, Brugge JS, Kaeser PS, Church G, et al. Rapid sequential in situ multiplexing with DNA-Exchange-Imaging in Neuronal Cells and Tissues. Nano Letters. PMID 28933153 DOI: 10.1021/Acs.Nanolett.7B02716  0.595
2017 Lubock NB, Zhang D, Sidore AM, Church GM, Kosuri S. A systematic comparison of error correction enzymes by next-generation sequencing. Nucleic Acids Research. 45: 9206-9217. PMID 28911123 DOI: 10.1093/Nar/Gkx691  0.789
2017 Chari R, Church GM. Beyond editing to writing large genomes. Nature Reviews. Genetics. PMID 28852223 DOI: 10.1038/Nrg.2017.59  0.425
2017 Niu D, Wei HJ, Lin L, George H, Wang T, Lee IH, Zhao HY, Wang Y, Kan Y, Shrock E, Lesha E, Wang G, Luo Y, Qing Y, Jiao D, ... ... Church GM, et al. Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9. Science (New York, N.Y.). PMID 28798043 DOI: 10.1126/Science.Aan4187  0.466
2017 Shipman SL, Nivala J, Macklis JD, Church GM. CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria. Nature. PMID 28700573 DOI: 10.1038/Nature23017  0.812
2017 Goodman DB, Kuznetsov G, Lajoie MJ, Ahern BW, Napolitano MG, Chen KY, Chen C, Church GM. Millstone: software for multiplex microbial genome analysis and engineering. Genome Biology. 18: 101. PMID 28545559 DOI: 10.1186/S13059-017-1223-1  0.822
2017 Kuznetsov G, Goodman DB, Filsinger GT, Landon M, Rohland N, Aach J, Lajoie MJ, Church GM. Optimizing complex phenotypes through model-guided multiplex genome engineering. Genome Biology. 18: 100. PMID 28545477 DOI: 10.1186/S13059-017-1217-Z  0.823
2017 Cai B, Li B, Kiga N, Thusberg J, Bergquist T, Chen YC, Niknafs N, Carter H, Tokheim C, Beleva-Guthrie V, Douville C, Bhattacharya R, Grace Yeo HT, Fan J, Sengupta S, ... ... Church G, et al. Matching phenotypes to whole genomes: Lessons learned from four iterations of the personal genome project community challenges. Human Mutation. PMID 28544481 DOI: 10.1002/Humu.23265  0.75
2017 Aach J, Lunshof J, Iyer E, Church GM. Correction: Addressing the ethical issues raised by synthetic human entities with embryo-like features. Elife. 6. PMID 28494857 DOI: 10.7554/Elife.27642  0.754
2017 Aach J, Lunshof J, Iyer E, Church GM. Addressing the ethical issues raised by synthetic human entities with embryo-like features. Elife. 6. PMID 28494856 DOI: 10.7554/Elife.20674  0.76
2017 Cybulski TR, Boyden ES, Church GM, Tyo KEJ, Kording KP. Nucleotide-time alignment for molecular recorders. Plos Computational Biology. 13: e1005483. PMID 28459860 DOI: 10.1371/Journal.Pcbi.1005483  0.314
2017 Noble C, Olejarz J, Esvelt KM, Church GM, Nowak MA. Evolutionary dynamics of CRISPR gene drives. Science Advances. 3: e1601964. PMID 28435878 DOI: 10.1126/Sciadv.1601964  0.696
2017 Chan Y, Tung M, Garruss AS, Zaranek SW, Chan YK, Lunshof JE, Zaranek AW, Ball MP, Chou MF, Lim ET, Church GM. An unbiased index to quantify participant's phenotypic contribution to an open-access cohort. Scientific Reports. 7: 46148. PMID 28387241 DOI: 10.1038/Srep46148  0.738
2017 Rock JM, Hopkins FF, Chavez A, Diallo M, Chase MR, Gerrick ER, Pritchard JR, Church GM, Rubin EJ, Sassetti CM, Schnappinger D, Fortune SM. Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform. Nature Microbiology. 2: 16274. PMID 28165460 DOI: 10.1038/Nmicrobiol.2016.274  0.359
2017 Chari R, Yeo NC, Chavez A, Church GM. sgRNA Scorer 2.0: A Species-Independent Model To Predict CRISPR/Cas9 Activity. Acs Synthetic Biology. PMID 28146356 DOI: 10.1021/Acssynbio.6B00343  0.303
2017 Wang G, Yang L, Grishin D, Rios X, Ye LY, Hu Y, Li K, Zhang D, Church GM, Pu WT. Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies. Nature Protocols. 12: 88-103. PMID 27929521 DOI: 10.1038/Nprot.2016.152  0.587
2017 Kalhor R, Mali P, Church GM. Rapidly evolving homing CRISPR barcodes. Nature Methods. 14: 195-200. PMID 27918539 DOI: 10.1038/Nmeth.4108  0.815
2016 Cho YS, Kim H, Kim HM, Jho S, Jun J, Lee YJ, Chae KS, Kim CG, Kim S, Eriksson A, Edwards JS, Lee S, Kim BC, Manica A, Oh TK, ... Church GM, et al. An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes. Nature Communications. 7: 13637. PMID 27882922 DOI: 10.1038/Ncomms13637  0.396
2016 Yang L, Briggs AW, Chew WL, Mali P, Guell M, Aach J, Goodman DB, Cox D, Kan Y, Lesha E, Soundararajan V, Zhang F, Church G. Engineering and optimising deaminase fusions for genome editing. Nature Communications. 7: 13330. PMID 27804970 DOI: 10.1038/Ncomms13330  0.829
2016 Soares AE, Novak BJ, Haile J, Heupink TH, Fjeldså J, Gilbert MT, Poinar H, Church GM, Shapiro B. Complete mitochondrial genomes of living and extinct pigeons revise the timing of the columbiform radiation. Bmc Evolutionary Biology. 16: 230. PMID 27782796 DOI: 10.1186/S12862-016-0800-3  0.365
2016 Stranges PB, Palla M, Kalachikov S, Nivala J, Dorwart M, Trans A, Kumar S, Porel M, Chien M, Tao C, Morozova I, Li Z, Shi S, Aberra A, Arnold C, ... ... Church GM, et al. Design and characterization of a nanopore-coupled polymerase for single-molecule DNA sequencing by synthesis on an electrode array. Proceedings of the National Academy of Sciences of the United States of America. 113: E6749-E6756. PMID 27729524 DOI: 10.1073/Pnas.1608271113  0.747
2016 Mao Q, Ciotlos S, Zhang RY, Ball MP, Chin R, Carnevali P, Barua N, Nguyen S, Agarwal MR, Clegg T, Connelly A, Vandewege W, Zaranek AW, Estep PW, Church GM, et al. The whole genome sequences and experimentally phased haplotypes of over 100 personal genomes. Gigascience. 5: 42. PMID 27724973 DOI: 10.1186/S13742-016-0148-Z  0.815
2016 Napolitano MG, Landon M, Gregg CJ, Lajoie MJ, Govindarajan L, Mosberg JA, Kuznetsov G, Goodman DB, Vargas-Rodriguez O, Isaacs FJ, Söll D, Church GM. Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 113: E5588-97. PMID 27601680 DOI: 10.1073/Pnas.1605856113  0.814
2016 Chew WL, Tabebordbar M, Cheng JK, Mali P, Wu EY, Ng AH, Zhu K, Wagers AJ, Church GM. A multifunctional AAV-CRISPR-Cas9 and its host response. Nature Methods. 13: 868-74. PMID 27595405 DOI: 10.1038/Nmeth.3993  0.661
2016 Vasiliou SK, Diamandis EP, Church GM, Greely HT, Baylis F, Thompson C, Schmitt-Ulms G. CRISPR-Cas9 System: Opportunities and Concerns. Clinical Chemistry. 62: 1304-11. PMID 27551006 DOI: 10.1373/Clinchem.2016.263186  0.455
2016 Ostrov N, Landon M, Guell M, Kuznetsov G, Teramoto J, Cervantes N, Zhou M, Singh K, Napolitano MG, Moosburner M, Shrock E, Pruitt BW, Conway N, Goodman DB, Gardner CL, ... ... Church GM, et al. Design, synthesis, and testing toward a 57-codon genome. Science (New York, N.Y.). 353: 819-22. PMID 27540174 DOI: 10.1126/Science.Aaf3639  0.818
2016 Chen F, Wassie AT, Cote AJ, Sinha A, Alon S, Asano S, Daugharthy ER, Chang JB, Marblestone A, Church GM, Raj A, Boyden ES. Nanoscale imaging of RNA with expansion microscopy. Nature Methods. 13: 679-84. PMID 27376770 DOI: 10.1038/Nmeth.3899  0.702
2016 Shipman SL, Nivala J, Macklis JD, Church GM. Molecular recordings by directed CRISPR spacer acquisition. Science (New York, N.Y.). 353: aaf1175. PMID 27284167 DOI: 10.1126/Science.Aaf1175  0.811
2016 Zook JM, Catoe D, McDaniel J, Vang L, Spies N, Sidow A, Weng Z, Liu Y, Mason CE, Alexander N, Henaff E, McIntyre AB, Chandramohan D, Chen F, Jaeger E, ... ... Church GM, et al. Extensive sequencing of seven human genomes to characterize benchmark reference materials. Scientific Data. 3: 160025. PMID 27271295 DOI: 10.1038/Sdata.2016.25  0.82
2016 Boeke JD, Church G, Hessel A, Kelley NJ, Arkin A, Cai Y, Carlson R, Chakravarti A, Cornish VW, Holt L, Isaacs FJ, Kuiken T, Lajoie M, Lessor T, Lunshof J, et al. The Genome Project-Write. Science (New York, N.Y.). PMID 27256881 DOI: 10.1126/Science.Aaf6850  0.803
2016 Vora S, Tuttle M, Cheng J, Church G. Next stop for the CRISPR revolution: RNA guided epigenetic regulators. The Febs Journal. PMID 27248712 DOI: 10.1111/Febs.13768  0.383
2016 Chavez A, Tuttle M, Pruitt BW, Ewen-Campen B, Chari R, Ter-Ovanesyan D, Haque SJ, Cecchi RJ, Kowal EJ, Buchthal J, Housden BE, Perrimon N, Collins JJ, Church G. Comparison of Cas9 activators in multiple species. Nature Methods. PMID 27214048 DOI: 10.1038/Nmeth.3871  0.45
2016 Braff JL, Yaung SJ, Esvelt KM, Church GM. Characterization of Cas9-Guide RNA Orthologs. Cold Spring Harbor Protocols. 2016: pdb.top086793. PMID 27140923 DOI: 10.1101/Pdb.Top086793  0.671
2016 Braff JL, Yaung SJ, Esvelt KM, Church GM. Characterizing Cas9 Protospacer-Adjacent Motifs with High-Throughput Sequencing of Library Depletion Experiments. Cold Spring Harbor Protocols. 2016: pdb.prot090183. PMID 27140916 DOI: 10.1101/Pdb.Prot090183  0.693
2016 Fuller CW, Kumar S, Porel M, Chien M, Bibillo A, Stranges PB, Dorwart M, Tao C, Li Z, Guo W, Shi S, Korenblum D, Trans A, Aguirre A, Liu E, ... ... Church GM, et al. Real-time single-molecule electronic DNA sequencing by synthesis using polymer-tagged nucleotides on a nanopore array. Proceedings of the National Academy of Sciences of the United States of America. 113: 5233-8. PMID 27091962 DOI: 10.1073/Pnas.1601782113  0.358
2016 Zheng Y, Lajoie MJ, Italia JS, Chin MA, Church GM, Chatterjee A. Performance of optimized noncanonical amino acid mutagenesis systems in the absence of release factor 1. Molecular Biosystems. 12: 1746-9. PMID 27027374 DOI: 10.1039/C6Mb00070C  0.703
2016 Rogers JK, Taylor ND, Church GM. Biosensor-based engineering of biosynthetic pathways. Current Opinion in Biotechnology. 42: 84-91. PMID 26998575 DOI: 10.1016/J.Copbio.2016.03.005  0.315
2016 Rogers JK, Church GM. Multiplexed Engineering in Biology. Trends in Biotechnology. 34: 198-206. PMID 26897356 DOI: 10.1016/J.Tibtech.2015.12.004  0.313
2016 Krueger AS, Munck C, Dantas G, Church GM, Galagan J, Lehár J, Sommer MO. Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis. Plos One. 11: e0147651. PMID 26821252 DOI: 10.1371/Journal.Pone.0147651  0.658
2016 Tabebordbar M, Zhu K, Cheng JK, Chew WL, Widrick JJ, Yan WX, Maesner C, Wu EY, Xiao R, Ran FA, Cong L, Zhang F, Vandenberghe LH, Church GM, Wagers AJ. In vivo gene editing in dystrophic mouse muscle and muscle stem cells. Science (New York, N.Y.). 351: 407-11. PMID 26721686 DOI: 10.1126/Science.Aad5177  0.683
2016 Biteen JS, Blainey PC, Cardon ZG, Chun M, Church GM, Dorrestein PC, Fraser SE, Gilbert JA, Jansson JK, Knight R, Miller JF, Ozcan A, Prather KA, Quake SR, Ruby EG, et al. Tools for the Microbiome: Nano and Beyond. Acs Nano. 10: 6-37. PMID 26695070 DOI: 10.1021/Acsnano.5B07826  0.303
2016 Taylor ND, Garruss AS, Moretti R, Chan S, Arbing MA, Cascio D, Rogers JK, Isaacs FJ, Kosuri S, Baker D, Fields S, Church GM, Raman S. Engineering an allosteric transcription factor to respond to new ligands. Nature Methods. 13: 177-83. PMID 26689263 DOI: 10.1038/Nmeth.3696  0.797
2016 Carr CE, Mojarro A, Tani J, Bhattaru SA, Zuber MT, Doebler R, Brown M, Herrington K, Talbot R, Fuller CW, Finney M, Church G, Ruvkun G. Advancing the search for extra-terrestrial genomes Ieee Aerospace Conference Proceedings. 2016. DOI: 10.1109/AERO.2016.7500859  0.515
2015 Church GM. Precision Chemistry for Precision Medicine. Acs Central Science. 1: 11-3. PMID 27162939 DOI: 10.1021/Acscentsci.5B00088  0.318
2015 Byrne SM, Church GM. Crispr-mediated Gene Targeting of Human Induced Pluripotent Stem Cells. Current Protocols in Stem Cell Biology. 35: 5A.8.1-22. PMID 26949444 DOI: 10.1002/9780470151808.Sc05A08S35  0.386
2015 Feng J, Jester BW, Tinberg CE, Mandell DJ, Antunes MS, Chari R, Morey KJ, Rios X, Medford JI, Church GM, Fields S, Baker D. A general strategy to construct small molecule biosensors in eukaryotes. Elife. 4. PMID 26714111 DOI: 10.7554/Elife.10606  0.42
2015 DiCarlo JE, Chavez A, Dietz SL, Esvelt KM, Church GM. Safeguarding CRISPR-Cas9 gene drives in yeast. Nature Biotechnology. 33: 1250-1255. PMID 26571100 DOI: 10.1038/Nbt.3412  0.819
2015 Yang L, Güell M, Niu D, George H, Lesha E, Grishin D, Aach J, Shrock E, Xu W, Poci J, Cortazio R, Wilkinson RA, Fishman JA, Church G. Genome-wide inactivation of porcine endogenous retroviruses (PERVs). Science (New York, N.Y.). PMID 26456528 DOI: 10.1126/Science.Aad1191  0.522
2015 Mandell DJ, Lajoie MJ, Mee MT, Takeuchi R, Kuznetsov G, Norville JE, Gregg CJ, Stoddard BL, Church GM. Corrigendum: Biocontainment of genetically modified organisms by synthetic protein design. Nature. 527: 264. PMID 26416745 DOI: 10.1038/Nature15536  0.686
2015 Lajoie MJ, Söll D, Church GM. Overcoming challenges in engineering the genetic code. Journal of Molecular Biology. PMID 26348789 DOI: 10.1016/J.Jmb.2015.09.003  0.71
2015 Kiani S, Chavez A, Tuttle M, Hall RN, Chari R, Ter-Ovanesyan D, Qian J, Pruitt BW, Beal J, Vora S, Buchthal J, Kowal EJ, Ebrahimkhani MR, Collins JJ, Weiss R, ... Church G, et al. Cas9 gRNA engineering for genome editing, activation and repression. Nature Methods. 12: 1051-4. PMID 26344044 DOI: 10.1038/Nmeth.3580  0.523
2015 Hinson JT, Chopra A, Nafissi N, Polacheck WJ, Benson CC, Swist S, Gorham J, Yang L, Schafer S, Sheng CC, Haghighi A, Homsy J, Hubner N, Church G, Cook SA, et al. HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. Science (New York, N.Y.). 349: 982-6. PMID 26315439 DOI: 10.1126/Science.Aaa5458  0.487
2015 Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, ... ... Church G, et al. Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes. Cell Metabolism. 22: 239-52. PMID 26244933 DOI: 10.1016/J.Cmet.2015.07.015  0.652
2015 Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, et al. BIOSAFETY. Safeguarding gene drive experiments in the laboratory. Science (New York, N.Y.). 349: 927-9. PMID 26229113 DOI: 10.1126/Science.Aac7932  0.644
2015 Chari R, Mali P, Moosburner M, Church GM. Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach. Nature Methods. 12: 823-6. PMID 26167643 DOI: 10.1038/Nmeth.3473  0.68
2015 Rogers JK, Guzman CD, Taylor ND, Raman S, Anderson K, Church GM. Synthetic biosensors for precise gene control and real-time monitoring of metabolites. Nucleic Acids Research. 43: 7648-60. PMID 26152303 DOI: 10.1093/Nar/Gkv616  0.56
2015 Yaung SJ, Deng L, Li N, Braff JL, Church GM, Bry L, Wang HH, Gerber GK. Improving microbial fitness in the mammalian gut by in vivo temporal functional metagenomics. Molecular Systems Biology. 11: 788. PMID 26148351 DOI: 10.15252/Msb.20145866  0.615
2015 Petit E, Coppi MV, Hayes JC, Tolonen AC, Warnick T, Latouf WG, Amisano D, Biddle A, Mukherjee S, Ivanova N, Lykidis A, Land M, Hauser L, Kyrpides N, Henrissat B, ... ... Church GM, et al. Genome and Transcriptome of Clostridium phytofermentans, Catalyst for the Direct Conversion of Plant Feedstocks to Fuels. Plos One. 10: e0118285. PMID 26035711 DOI: 10.1371/Journal.Pone.0118285  0.332
2015 Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, et al. Biotechnology. A prudent path forward for genomic engineering and germline gene modification. Science (New York, N.Y.). 348: 36-8. PMID 25791083 DOI: 10.1126/Science.Aab1028  0.415
2015 Yaung SJ, Deng L, Li N, Braff JL, Church GM, Bry L, Wang HH, Gerber GK. Improving microbial fitness in the mammalian gut by in vivo temporal functional metagenomics. Molecular Systems Biology. 11: 788. PMID 25762151 DOI: 10.15252/msb.20145866  0.567
2015 Chavez A, Scheiman J, Vora S, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, ... ... Church GM, et al. Highly efficient Cas9-mediated transcriptional programming. Nature Methods. 12: 326-8. PMID 25730490 DOI: 10.1038/Nmeth.3312  0.471
2015 Lee JH, Daugharthy ER, Scheiman J, Kalhor R, Ferrante TC, Terry R, Turczyk BM, Yang JL, Lee HS, Aach J, Zhang K, Church GM. Fluorescent in situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues. Nature Protocols. 10: 442-58. PMID 25675209 DOI: 10.1038/Nprot.2014.191  0.781
2015 Mandell DJ, Lajoie MJ, Mee MT, Takeuchi R, Kuznetsov G, Norville JE, Gregg CJ, Stoddard BL, Church GM. Biocontainment of genetically modified organisms by synthetic protein design. Nature. 518: 55-60. PMID 25607366 DOI: 10.1038/Nature14121  0.713
2015 Keane M, Semeiks J, Webb AE, Li YI, Quesada V, Craig T, Madsen LB, van Dam S, Brawand D, Marques PI, Michalak P, Kang L, Bhak J, Yim HS, Grishin NV, ... ... Church GM, et al. Insights into the evolution of longevity from the bowhead whale genome. Cell Reports. 10: 112-22. PMID 25565328 DOI: 10.1016/J.Celrep.2014.12.008  0.376
2015 Yaung SJ, Esvelt KM, Church GM. Complete Genome Sequences of T4-Like Bacteriophages RB3, RB5, RB6, RB7, RB9, RB10, RB27, RB33, RB55, RB59, and RB68. Genome Announcements. 3. PMID 25555735 DOI: 10.1128/Genomea.01122-14  0.674
2015 Drmanac R, Peters BA, Church GM, Reid CA, Xu X. Accurate whole genome sequencing as the ultimate genetic test. Clinical Chemistry. 61: 305-6. PMID 25479756 DOI: 10.1373/Clinchem.2014.224907  0.434
2015 Byrne SM, Ortiz L, Mali P, Aach J, Church GM. Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells. Nucleic Acids Research. 43: e21. PMID 25414332 DOI: 10.1093/Nar/Gku1246  0.655
2015 Bonde MT, Kosuri S, Genee HJ, Sarup-Lytzen K, Church GM, Sommer MO, Wang HH. Direct mutagenesis of thousands of genomic targets using microarray-derived oligonucleotides. Acs Synthetic Biology. 4: 17-22. PMID 24856730 DOI: 10.1021/Sb5001565  0.825
2015 Feng J, Jester BW, Tinberg CE, Mandell DJ, Antunes MS, Chari R, Morey KJ, Rios X, Medford JI, Church GM, Fields S, Baker D. Author response: A general strategy to construct small molecule biosensors in eukaryotes Elife. DOI: 10.7554/Elife.10606.018  0.356
2015 Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, ... ... Church G, et al. Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes Cell Metabolism. 22: 239-252. DOI: 10.1016/j.cmet.2015.07.015  0.603
2014 Cybulski TR, Glaser JI, Marblestone AH, Zamft BM, Boyden ES, Church GM, Kording KP. Spatial information in large-scale neural recordings. Frontiers in Computational Neuroscience. 8: 172. PMID 25653613 DOI: 10.3389/Fncom.2014.00172  0.69
2014 Raman S, Rogers JK, Taylor ND, Church GM. Evolution-guided optimization of biosynthetic pathways. Proceedings of the National Academy of Sciences of the United States of America. 111: 17803-8. PMID 25453111 DOI: 10.1073/Pnas.1409523111  0.606
2014 Yang L, Grishin D, Wang G, Aach J, Zhang CZ, Chari R, Homsy J, Cai X, Zhao Y, Fan JB, Seidman C, Seidman J, Pu W, Church G. Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells. Nature Communications. 5: 5507. PMID 25425480 DOI: 10.1038/Ncomms6507  0.588
2014 Hoehe MR, Church GM, Lehrach H, Kroslak T, Palczewski S, Nowick K, Schulz S, Suk EK, Huebsch T. Multiple haplotype-resolved genomes reveal population patterns of gene and protein diplotypes. Nature Communications. 5: 5569. PMID 25424553 DOI: 10.1038/Ncomms6569  0.439
2014 Busskamp V, Lewis NE, Guye P, Ng AH, Shipman SL, Byrne SM, Sanjana NE, Murn J, Li Y, Li S, Stadler M, Weiss R, Church GM. Rapid neurogenesis through transcriptional activation in human stem cells. Molecular Systems Biology. 10: 760. PMID 25403753 DOI: 10.15252/Msb.20145508  0.774
2014 Byrne SM, Mali P, Church GM. Genome editing in human stem cells. Methods in Enzymology. 546: 119-38. PMID 25398338 DOI: 10.1016/B978-0-12-801185-0.00006-4  0.665
2014 Raman S, Taylor N, Genuth N, Fields S, Church GM. Engineering allostery. Trends in Genetics : Tig. 30: 521-8. PMID 25306102 DOI: 10.1016/j.tig.2014.09.004  0.542
2014 Gu L, Li C, Aach J, Hill DE, Vidal M, Church GM. Multiplex single-molecule interaction profiling of DNA-barcoded proteins. Nature. 515: 554-7. PMID 25252978 DOI: 10.1038/Nature13761  0.343
2014 Keane M, Craig T, Alföldi J, Berlin AM, Johnson J, Seluanov A, Gorbunova V, Di Palma F, Lindblad-Toh K, Church GM, de Magalhães JP. The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations. Bioinformatics (Oxford, England). 30: 3558-60. PMID 25172923 DOI: 10.1093/Bioinformatics/Btu579  0.347
2014 Esvelt KM, Smidler AL, Catteruccia F, Church GM. Concerning RNA-guided gene drives for the alteration of wild populations. Elife. 3. PMID 25035423 DOI: 10.7554/Elife.03401  0.684
2014 Oye KA, Esvelt K, Appleton E, Catteruccia F, Church G, Kuiken T, Lightfoot SB, McNamara J, Smidler A, Collins JP. Biotechnology. Regulating gene drives. Science (New York, N.Y.). 345: 626-8. PMID 25035410 DOI: 10.1126/Science.1254287  0.679
2014 Güell M, Yang L, Church GM. Genome editing assessment using CRISPR Genome Analyzer (CRISPR-GA). Bioinformatics (Oxford, England). 30: 2968-70. PMID 24990609 DOI: 10.1093/Bioinformatics/Btu427  0.586
2014 Yang L, Yang JL, Byrne S, Pan J, Church GM. CRISPR/Cas9-Directed Genome Editing of Cultured Cells. Current Protocols in Molecular Biology. 107: 31.1.1-17. PMID 24984853 DOI: 10.1002/0471142727.Mb3101S107  0.581
2014 Yaung SJ, Esvelt KM, Church GM. CRISPR/Cas9-mediated phage resistance is not impeded by the DNA modifications of phage T4. Plos One. 9: e98811. PMID 24886988 DOI: 10.1371/Journal.Pone.0098811  0.669
2014 Chatterjee A, Lajoie MJ, Xiao H, Church GM, Schultz PG. A bacterial strain with a unique quadruplet codon specifying non-native amino acids. Chembiochem : a European Journal of Chemical Biology. 15: 1782-6. PMID 24867343 DOI: 10.1002/Cbic.201402104  0.702
2014 Montague TG, Cruz JM, Gagnon JA, Church GM, Valen E. CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing. Nucleic Acids Research. 42: W401-7. PMID 24861617 DOI: 10.1093/Nar/Gku410  0.436
2014 Yaung SJ, Church GM, Wang HH. Recent progress in engineering human-associated microbiomes. Methods in Molecular Biology (Clifton, N.J.). 1151: 3-25. PMID 24838875 DOI: 10.1007/978-1-4939-0554-6_1  0.531
2014 Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, ... ... Church GM, et al. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nature Medicine. 20: 616-23. PMID 24813252 DOI: 10.1038/Nm.3545  0.633
2014 Kosuri S, Church GM. Large-scale de novo DNA synthesis: technologies and applications. Nature Methods. 11: 499-507. PMID 24781323 DOI: 10.1038/Nmeth.2918  0.704
2014 Mee MT, Collins JJ, Church GM, Wang HH. Syntrophic exchange in synthetic microbial communities. Proceedings of the National Academy of Sciences of the United States of America. 111: E2149-56. PMID 24778240 DOI: 10.1073/Pnas.1405641111  0.599
2014 Ball MP, Bobe JR, Chou MF, Clegg T, Estep PW, Lunshof JE, Vandewege W, Zaranek A, Church GM. Harvard Personal Genome Project: lessons from participatory public research. Genome Medicine. 6: 10. PMID 24713084 DOI: 10.1186/Gm527  0.799
2014 Laserson U, Vigneault F, Gadala-Maria D, Yaari G, Uduman M, Vander Heiden JA, Kelton W, Taek Jung S, Liu Y, Laserson J, Chari R, Lee JH, Bachelet I, Hickey B, Lieberman-Aiden E, ... ... Church GM, et al. High-resolution antibody dynamics of vaccine-induced immune responses. Proceedings of the National Academy of Sciences of the United States of America. 111: 4928-33. PMID 24639495 DOI: 10.1073/Pnas.1323862111  0.718
2014 Lee JH, Daugharthy ER, Scheiman J, Kalhor R, Yang JL, Ferrante TC, Terry R, Jeanty SS, Li C, Amamoto R, Peters DT, Turczyk BM, Marblestone AH, Inverso SA, Bernard A, ... ... Church GM, et al. Highly multiplexed subcellular RNA sequencing in situ. Science (New York, N.Y.). 343: 1360-3. PMID 24578530 DOI: 10.1126/Science.1250212  0.81
2014 Yang L, Mali P, Kim-Kiselak C, Church G. CRISPR-Cas-mediated targeted genome editing in human cells. Methods in Molecular Biology (Clifton, N.J.). 1114: 245-67. PMID 24557908 DOI: 10.1007/978-1-62703-761-7_16  0.748
2014 Bröcker MJ, Ho JM, Church GM, Söll D, O'Donoghue P. Recoding the genetic code with selenocysteine. Angewandte Chemie (International Ed. in English). 53: 319-23. PMID 24511637 DOI: 10.1002/Anie.201308584  0.327
2014 Gregg CJ, Lajoie MJ, Napolitano MG, Mosberg JA, Goodman DB, Aach J, Isaacs FJ, Church GM. Rational optimization of tolC as a powerful dual selectable marker for genome engineering. Nucleic Acids Research. 42: 4779-90. PMID 24452804 DOI: 10.1093/Nar/Gkt1374  0.791
2014 Uduman M, Shlomchik MJ, Vigneault F, Church GM, Kleinstein SH. Integrating B cell lineage information into statistical tests for detecting selection in Ig sequences. Journal of Immunology (Baltimore, Md. : 1950). 192: 867-74. PMID 24376267 DOI: 10.4049/Jimmunol.1301551  0.341
2014 Robasky K, Lewis NE, Church GM. The role of replicates for error mitigation in next-generation sequencing. Nature Reviews. Genetics. 15: 56-62. PMID 24322726 DOI: 10.1038/Nrg3655  0.556
2014 Ling J, Daoud R, Lajoie MJ, Church GM, Söll D, Lang BF. Natural reassignment of CUU and CUA sense codons to alanine in Ashbya mitochondria. Nucleic Acids Research. 42: 499-508. PMID 24049072 DOI: 10.1093/Nar/Gkt842  0.705
2014 Umbarger MA, Kennedy CJ, Saunders P, Breton B, Chennagiri N, Emhoff J, Greger V, Hallam S, Maganzini D, Micale C, Nizzari MM, Towne CF, Church GM, Porreca GJ. Next-generation carrier screening. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 16: 132-40. PMID 23765052 DOI: 10.1038/Gim.2013.83  0.782
2014 Esvelt KM, Smidler AL, Catteruccia F, Church GM. Author response: Concerning RNA-guided gene drives for the alteration of wild populations Elife. DOI: 10.7554/Elife.03401.019  0.648
2014 Drukier AK, Cantor C, Chonofsky M, Church GM, Fagaly RL, Freese K, Lopez A, Sano T, Savage C, Wong WP. New class of biological detectors for WIMPs International Journal of Modern Physics A. 29. DOI: 10.1142/S0217751X14430076  0.463
2013 Sok D, Laserson U, Laserson J, Liu Y, Vigneault F, Julien JP, Briney B, Ramos A, Saye KF, Le K, Mahan A, Wang S, Kardar M, Yaari G, Walker LM, ... ... Church GM, et al. The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies. Plos Pathogens. 9: e1003754. PMID 24278016 DOI: 10.1371/Journal.Ppat.1003754  0.69
2013 Marblestone AH, Zamft BM, Maguire YG, Shapiro MG, Cybulski TR, Glaser JI, Amodei D, Stranges PB, Kalhor R, Dalrymple DA, Seo D, Alon E, Maharbiz MM, Carmena JM, Rabaey JM, ... ... Church GM, et al. Physical principles for scalable neural recording. Frontiers in Computational Neuroscience. 7: 137. PMID 24187539 DOI: 10.3389/Fncom.2013.00137  0.771
2013 Li JB, Church GM. Deciphering the functions and regulation of brain-enriched A-to-I RNA editing. Nature Neuroscience. 16: 1518-22. PMID 24165678 DOI: 10.1038/Nn.3539  0.403
2013 DiCarlo JE, Conley AJ, Penttilä M, Jäntti J, Wang HH, Church GM. Yeast oligo-mediated genome engineering (YOGE). Acs Synthetic Biology. 2: 741-9. PMID 24160921 DOI: 10.1021/Sb400117C  0.822
2013 Lajoie MJ, Kosuri S, Mosberg JA, Gregg CJ, Zhang D, Church GM. Probing the limits of genetic recoding in essential genes. Science (New York, N.Y.). 342: 361-3. PMID 24136967 DOI: 10.1126/Science.1241460  0.82
2013 Lajoie MJ, Rovner AJ, Goodman DB, Aerni HR, Haimovich AD, Kuznetsov G, Mercer JA, Wang HH, Carr PA, Mosberg JA, Rohland N, Schultz PG, Jacobson JM, Rinehart J, Church GM, et al. Genomically recoded organisms expand biological functions. Science (New York, N.Y.). 342: 357-60. PMID 24136966 DOI: 10.1126/Science.1241459  0.803
2013 Church G. Improving genome understanding. Nature. 502: 143. PMID 24108012 DOI: 10.1038/502143A  0.371
2013 Mali P, Esvelt KM, Church GM. Cas9 as a versatile tool for engineering biology. Nature Methods. 10: 957-63. PMID 24076990 DOI: 10.1038/Nmeth.2649  0.779
2013 Esvelt KM, Mali P, Braff JL, Moosburner M, Yaung SJ, Church GM. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nature Methods. 10: 1116-21. PMID 24076762 DOI: 10.1038/nmeth.2681  0.768
2013 Goodman DB, Church GM, Kosuri S. Causes and effects of N-terminal codon bias in bacterial genes. Science (New York, N.Y.). 342: 475-9. PMID 24072823 DOI: 10.1126/Science.1241934  0.784
2013 Eroshenko N, Church GM. Mutants of Cre recombinase with improved accuracy. Nature Communications. 4: 2509. PMID 24056590 DOI: 10.1038/Ncomms3509  0.418
2013 Lo C, Liu R, Lee J, Robasky K, Byrne S, Lucchesi C, Aach J, Church G, Bafna V, Zhang K. On the design of clone-based haplotyping. Genome Biology. 14: R100. PMID 24028704 DOI: 10.1186/Gb-2013-14-9-R100  0.501
2013 Tzur YB, Friedland AE, Nadarajan S, Church GM, Calarco JA, Colaiácovo MP. Heritable custom genomic modifications in Caenorhabditis elegans via a CRISPR-Cas9 system. Genetics. 195: 1181-5. PMID 23979579 DOI: 10.1534/Genetics.113.156075  0.413
2013 Payne AC, Andregg M, Kemmish K, Hamalainen M, Bowell C, Bleloch A, Klejwa N, Lehrach W, Schatz K, Stark H, Marblestone A, Church G, Own CS, Andregg W. Molecular threading: mechanical extraction, stretching and placement of DNA molecules from a liquid-air interface. Plos One. 8: e69058. PMID 23935923 DOI: 10.1371/Journal.Pone.0069058  0.707
2013 Li JF, Norville JE, Aach J, McCormack M, Zhang D, Bush J, Church GM, Sheen J. Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nature Biotechnology. 31: 688-91. PMID 23929339 DOI: 10.1038/Nbt.2654  0.371
2013 Kosuri S, Goodman DB, Cambray G, Mutalik VK, Gao Y, Arkin AP, Endy D, Church GM. Composability of regulatory sequences controlling transcription and translation in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 110: 14024-9. PMID 23924614 DOI: 10.1073/Pnas.1301301110  0.802
2013 Yang L, Guell M, Byrne S, Yang JL, De Los Angeles A, Mali P, Aach J, Kim-Kiselak C, Briggs AW, Rios X, Huang PY, Daley G, Church G. Optimization of scarless human stem cell genome editing. Nucleic Acids Research. 41: 9049-61. PMID 23907390 DOI: 10.1093/Nar/Gkt555  0.733
2013 Mali P, Aach J, Stranges PB, Esvelt KM, Moosburner M, Kosuri S, Yang L, Church GM. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nature Biotechnology. 31: 833-8. PMID 23907171 DOI: 10.1038/Nbt.2675  0.813
2013 Konermann S, Brigham MD, Trevino AE, Hsu PD, Heidenreich M, Cong L, Platt RJ, Scott DA, Church GM, Zhang F. Optical control of mammalian endogenous transcription and epigenetic states. Nature. 500: 472-6. PMID 23877069 DOI: 10.1038/Nature12466  0.814
2013 Glaser JI, Zamft BM, Marblestone AH, Moffitt JR, Tyo K, Boyden ES, Church G, Kording KP. Statistical analysis of molecular signal recording. Plos Computational Biology. 9: e1003145. PMID 23874187 DOI: 10.1371/Journal.Pcbi.1003145  0.707
2013 Friedland AE, Tzur YB, Esvelt KM, Colaiácovo MP, Church GM, Calarco JA. Heritable genome editing in C. elegans via a CRISPR-Cas9 system. Nature Methods. 10: 741-3. PMID 23817069 DOI: 10.1038/Nmeth.2532  0.707
2013 Jewett MC, Fritz BR, Timmerman LE, Church GM. In vitro integration of ribosomal RNA synthesis, ribosome assembly, and translation. Molecular Systems Biology. 9: 678. PMID 23799452 DOI: 10.1038/Msb.2013.31  0.324
2013 Alivisatos AP, Andrews AM, Boyden ES, Chun M, Church GM, Deisseroth K, Donoghue JP, Fraser SE, Lippincott-Schwartz J, Looger LL, Masmanidis S, McEuen PL, Nurmikko AV, Park H, Peterka DS, et al. Nanotools for neuroscience and brain activity mapping. Acs Nano. 7: 1850-66. PMID 23514423 DOI: 10.1021/Nn4012847  0.467
2013 Zhu J, Larman HB, Gao G, Somwar R, Zhang Z, Laserson U, Ciccia A, Pavlova N, Church G, Zhang W, Kesari S, Elledge SJ. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). Nature Biotechnology. 31: 331-4. PMID 23503679 DOI: 10.1038/Nbt.2539  0.714
2013 Mali P, Aach J, Lee JH, Levner D, Nip L, Church GM. Barcoding cells using cell-surface programmable DNA-binding domains. Nature Methods. 10: 403-6. PMID 23503053 DOI: 10.1038/Nmeth.2407  0.645
2013 Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC, et al. PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. Journal of Autoimmunity. 43: 1-9. PMID 23497938 DOI: 10.1016/J.Jaut.2013.01.013  0.695
2013 Alivisatos AP, Chun M, Church GM, Deisseroth K, Donoghue JP, Greenspan RJ, McEuen PL, Roukes ML, Sejnowski TJ, Weiss PS, Yuste R. Neuroscience. The brain activity map. Science (New York, N.Y.). 339: 1284-5. PMID 23470729 DOI: 10.1126/Science.1236939  0.437
2013 DiCarlo JE, Norville JE, Mali P, Rios X, Aach J, Church GM. Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems. Nucleic Acids Research. 41: 4336-43. PMID 23460208 DOI: 10.1093/Nar/Gkt135  0.822
2013 Church GM. Reading and writing omes. Molecular Systems Biology. 9: 642. PMID 23340848 DOI: 10.1038/Msb.2012.75  0.392
2013 Plank M, Hu G, Silva AS, Wood SH, Hesketh EE, Janssens G, Macedo A, de Magalhães JP, Church GM. An analysis and validation pipeline for large-scale RNAi-based screens. Scientific Reports. 3: 1076. PMID 23326633 DOI: 10.1038/Srep01076  0.312
2013 Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, Norville JE, Church GM. RNA-guided human genome engineering via Cas9. Science (New York, N.Y.). 339: 823-6. PMID 23287722 DOI: 10.1126/Science.1232033  0.812
2013 Sok D, Laserson U, Laserson J, Liu Y, Vigneault F, Julien J, Briney B, Ramos A, Saye KF, Le K, Mahan A, Wang S, Kardar M, Yaari G, Walker LM, ... ... Church GM, et al. Correction: The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies Plos Pathogens. 9. DOI: 10.1371/annotation/f1f8c791-61e9-45c6-a455-92c6dadf9f06  0.638
2013 Wang HH, Mee MT, Church GM. Applications of Engineered Synthetic Ecosystems Synthetic Biology. 317-325. DOI: 10.1016/B978-0-12-394430-6.00017-0  0.428
2012 Eroshenko N, Kosuri S, Marblestone AH, Conway N, Church GM. Gene Assembly from Chip-Synthesized Oligonucleotides. Current Protocols in Chemical Biology. 2012. PMID 25077042 DOI: 10.1002/9780470559277.Ch110190  0.8
2012 Lin C, Jungmann R, Leifer AM, Li C, Levner D, Church GM, Shih WM, Yin P. Submicrometre geometrically encoded fluorescent barcodes self-assembled from DNA. Nature Chemistry. 4: 832-9. PMID 23000997 DOI: 10.1038/Nchem.1451  0.65
2012 Mosberg JA, Gregg CJ, Lajoie MJ, Wang HH, Church GM. Improving lambda red genome engineering in Escherichia coli via rational removal of endogenous nucleases. Plos One. 7: e44638. PMID 22957093 DOI: 10.1371/Journal.Pone.0044638  0.811
2012 Juhas M, Eberl L, Church GM. Essential genes as antimicrobial targets and cornerstones of synthetic biology. Trends in Biotechnology. 30: 601-7. PMID 22951051 DOI: 10.1016/J.Tibtech.2012.08.002  0.331
2012 Zamft BM, Marblestone AH, Kording K, Schmidt D, Martin-Alarcon D, Tyo K, Boyden ES, Church G. Measuring cation dependent DNA polymerase fidelity landscapes by deep sequencing. Plos One. 7: e43876. PMID 22928047 DOI: 10.1371/Journal.Pone.0043876  0.727
2012 Lajoie MJ, Gregg CJ, Mosberg JA, Washington GC, Church GM. Manipulating replisome dynamics to enhance lambda Red-mediated multiplex genome engineering. Nucleic Acids Research. 40: e170. PMID 22904085 DOI: 10.1093/Nar/Gks751  0.817
2012 Church GM, Gao Y, Kosuri S. Next-generation digital information storage in DNA. Science (New York, N.Y.). 337: 1628. PMID 22903519 DOI: 10.1126/Science.1226355  0.696
2012 Ball MP, Thakuria JV, Zaranek AW, Clegg T, Rosenbaum AM, Wu X, Angrist M, Bhak J, Bobe J, Callow MJ, Cano C, Chou MF, Chung WK, Douglas SM, Estep PW, ... ... Church GM, et al. A public resource facilitating clinical use of genomes. Proceedings of the National Academy of Sciences of the United States of America. 109: 11920-7. PMID 22797899 DOI: 10.1073/Pnas.1201904109  0.805
2012 Peters BA, Kermani BG, Sparks AB, Alferov O, Hong P, Alexeev A, Jiang Y, Dahl F, Tang YT, Haas J, Robasky K, Zaranek AW, Lee JH, Ball MP, Peterson JE, ... ... Church GM, et al. Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells. Nature. 487: 190-5. PMID 22785314 DOI: 10.1038/Nature11236  0.813
2012 Briggs AW, Rios X, Chari R, Yang L, Zhang F, Mali P, Church GM. Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers. Nucleic Acids Research. 40: e117. PMID 22740649 DOI: 10.1093/Nar/Gks624  0.741
2012 Wang HH, Huang PY, Xu G, Haas W, Marblestone A, Li J, Gygi SP, Forster AC, Jewett MC, Church GM. Multiplexed in vivo His-tagging of enzyme pathways for in vitro single-pot multienzyme catalysis. Acs Synthetic Biology. 1: 43-52. PMID 22737598 DOI: 10.1021/Sb3000029  0.781
2012 Carr PA, Wang HH, Sterling B, Isaacs FJ, Lajoie MJ, Xu G, Church GM, Jacobson JM. Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection. Nucleic Acids Research. 40: e132. PMID 22638574 DOI: 10.1093/Nar/Gks455  0.819
2012 Rios X, Briggs AW, Christodoulou D, Gorham JM, Seidman JG, Church GM. Stable gene targeting in human cells using single-strand oligonucleotides with modified bases. Plos One. 7: e36697. PMID 22615794 DOI: 10.1371/Journal.Pone.0036697  0.418
2012 Wang HH, Kim H, Cong L, Jeong J, Bang D, Church GM. Genome-scale promoter engineering by coselection MAGE. Nature Methods. 9: 591-3. PMID 22484848 DOI: 10.1038/Nmeth.1971  0.808
2012 Thakuria JV, Zaranek AW, Church GM, Berry GT. Back to the future: from genome to metabolome. Human Mutation. 33: 809-12. PMID 22431014 DOI: 10.1002/Humu.22073  0.789
2012 Gianoulis TA, Griffin MA, Spakowicz DJ, Dunican BF, Alpha CJ, Sboner A, Sismour AM, Kodira C, Egholm M, Church GM, Gerstein MB, Strobel SA. Genomic analysis of the hydrocarbon-producing, cellulolytic, endophytic fungus Ascocoryne sarcoides. Plos Genetics. 8: e1002558. PMID 22396667 DOI: 10.1371/Journal.Pgen.1002558  0.409
2012 Douglas SM, Bachelet I, Church GM. A logic-gated nanorobot for targeted transport of molecular payloads. Science (New York, N.Y.). 335: 831-4. PMID 22344439 DOI: 10.1126/Science.1214081  0.658
2011 Yu C, Li Y, Holmes A, Szafranski K, Faulkes CG, Coen CW, Buffenstein R, Platzer M, de Magalhães JP, Church GM. RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice. Plos One. 6: e26729. PMID 22073188 DOI: 10.1371/Journal.Pone.0026729  0.332
2011 Carmi S, Church GM, Levanon EY. Large-scale DNA editing of retrotransposons accelerates mammalian genome evolution. Nature Communications. 2: 519. PMID 22044998 DOI: 10.1038/Ncomms1525  0.436
2011 Umbarger MA, Toro E, Wright MA, Porreca GJ, Baù D, Hong SH, Fero MJ, Zhu LJ, Marti-Renom MA, McAdams HH, Shapiro L, Dekker J, Church GM. The three-dimensional architecture of a bacterial genome and its alteration by genetic perturbation. Molecular Cell. 44: 252-64. PMID 22017872 DOI: 10.1016/j.molcel.2011.09.010  0.813
2011 Church GM. New technologies for integrating genomic, environmental and trait data. Journal of Clinical Sleep Medicine : Jcsm : Official Publication of the American Academy of Sleep Medicine. 7: S43-4. PMID 22003332 DOI: 10.5664/Jcsm.1362  0.399
2011 Shendure JA, Porreca GJ, Church GM, Gardner AF, Hendrickson CL, Kieleczawa J, Slatko BE. Overview of DNA sequencing strategies. Current Protocols in Molecular Biology. Unit7.1. PMID 21987056 DOI: 10.1002/0471142727.Mb0701S96  0.807
2011 Dewey FE, Chen R, Cordero SP, Ormond KE, Caleshu C, Karczewski KJ, Whirl-Carrillo M, Wheeler MT, Dudley JT, Byrnes JK, Cornejo OE, Knowles JW, Woon M, Sangkuhl K, Gong L, ... ... Church GM, et al. Phased whole-genome genetic risk in a family quartet using a major allele reference sequence. Plos Genetics. 7: e1002280. PMID 21935354 DOI: 10.1371/Journal.Pgen.1002280  0.812
2011 Isaacs FJ, Carr PA, Wang HH, Lajoie MJ, Sterling B, Kraal L, Tolonen AC, Gianoulis TA, Goodman DB, Reppas NB, Emig CJ, Bang D, Hwang SJ, Jewett MC, Jacobson JM, ... Church GM, et al. Precise manipulation of chromosomes in vivo enables genome-wide codon replacement. Science (New York, N.Y.). 333: 348-53. PMID 21764749 DOI: 10.1126/Science.1205822  0.818
2011 Wang HH, Xu G, Vonner AJ, Church G. Modified bases enable high-efficiency oligonucleotide-mediated allelic replacement via mismatch repair evasion. Nucleic Acids Research. 39: 7336-47. PMID 21609953 DOI: 10.1093/Nar/Gkr183  0.582
2011 Larman HB, Zhao Z, Laserson U, Li MZ, Ciccia A, Gakidis MA, Church GM, Kesari S, Leproust EM, Solimini NL, Elledge SJ. Autoantigen discovery with a synthetic human peptidome. Nature Biotechnology. 29: 535-41. PMID 21602805 DOI: 10.1038/Nbt.1856  0.727
2011 Wang HH, Church GM. Multiplexed genome engineering and genotyping methods applications for synthetic biology and metabolic engineering. Methods in Enzymology. 498: 409-26. PMID 21601688 DOI: 10.1016/B978-0-12-385120-8.00018-8  0.61
2011 Zhang F, Cong L, Lodato S, Kosuri S, Church GM, Arlotta P. Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nature Biotechnology. 29: 149-53. PMID 21248753 DOI: 10.1038/Nbt.1775  0.818
2011 Church G. Thoughts on the Manchester Manifesto Prometheus (United Kingdom). 29: 343-344. DOI: 10.1080/08109028.2011.631273  0.394
2011 Nelson FK, Snyder M, Gardner AF, Hendrickson CL, Shendure JA, Porreca GJ, Church GM, Ausubel FM, Ju J, Kieleczawa J, Slatko BE. Introduction and historical overview of DNA sequencing Current Protocols in Molecular Biology. DOI: 10.1002/0471142727.mb0700s96  0.8
2010 Sommer MO, Church GM, Dantas G. The human microbiome harbors a diverse reservoir of antibiotic resistance genes. Virulence. 1: 299-303. PMID 21178459 DOI: 10.4161/Viru.1.4.12010  0.655
2010 Matzas M, Stähler PF, Kefer N, Siebelt N, Boisguérin V, Leonard JT, Keller A, Stähler CF, Häberle P, Gharizadeh B, Babrzadeh F, Church GM. High-fidelity gene synthesis by retrieval of sequence-verified DNA identified using high-throughput pyrosequencing. Nature Biotechnology. 28: 1291-4. PMID 21113166 DOI: 10.1038/Nbt.1710  0.377
2010 Kosuri S, Eroshenko N, Leproust EM, Super M, Way J, Li JB, Church GM. Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips. Nature Biotechnology. 28: 1295-9. PMID 21113165 DOI: 10.1038/Nbt.1716  0.735
2010 Mosberg JA, Lajoie MJ, Church GM. Lambda red recombineering in Escherichia coli occurs through a fully single-stranded intermediate. Genetics. 186: 791-9. PMID 20813883 DOI: 10.1534/Genetics.110.120782  0.801
2010 Loh YH, Hartung O, Li H, Guo C, Sahalie JM, Manos PD, Urbach A, Heffner GC, Grskovic M, Vigneault F, Lensch MW, Park IH, Agarwal S, Church GM, Collins JJ, et al. Reprogramming of T cells from human peripheral blood. Cell Stem Cell. 7: 15-9. PMID 20621044 DOI: 10.1016/J.Stem.2010.06.004  0.397
2010 Zaranek AW, Levanon EY, Zecharia T, Clegg T, Church GM. A survey of genomic traces reveals a common sequencing error, RNA editing, and DNA editing. Plos Genetics. 6: e1000954. PMID 20531933 DOI: 10.1371/Journal.Pgen.1000954  0.795
2010 Bedau M, Church G, Rasmussen S, Caplan A, Benner S, Fussenegger M, Collins J, Deamer D. Life after the synthetic cell. Nature. 465: 422-4. PMID 20495545 DOI: 10.1038/465422A  0.532
2010 Ashley EA, Butte AJ, Wheeler MT, Chen R, Klein TE, Dewey FE, Dudley JT, Ormond KE, Pavlovic A, Morgan AA, Pushkarev D, Neff NF, Hudgins L, Gong L, Hodges LM, ... ... Church GM, et al. Clinical assessment incorporating a personal genome. Lancet (London, England). 375: 1525-35. PMID 20435227 DOI: 10.1016/S0140-6736(10)60452-7  0.8
2010 Sommer MO, Church GM, Dantas G. A functional metagenomic approach for expanding the synthetic biology toolbox for biomass conversion. Molecular Systems Biology. 6: 360. PMID 20393580 DOI: 10.1038/Msb.2010.16  0.69
2010 Drmanac R, Sparks AB, Callow MJ, Halpern AL, Burns NL, Kermani BG, Carnevali P, Nazarenko I, Nilsen GB, Yeung G, Dahl F, Fernandez A, Staker B, Pant KP, Baccash J, ... ... Church GM, et al. Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays. Science (New York, N.Y.). 327: 78-81. PMID 19892942 DOI: 10.1126/Science.1181498  0.825
2010 Sullivan GJ, Hay DC, Park IH, Fletcher J, Hannoun Z, Payne CM, Dalgetty D, Black JR, Ross JA, Samuel K, Wang G, Daley GQ, Lee JH, Church GM, Forbes SJ, et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology (Baltimore, Md.). 51: 329-35. PMID 19877180 DOI: 10.1002/Hep.23335  0.357
2010 Church G. Reading and writing genomes Genome Biology. 11: I2. DOI: 10.1186/Gb-2010-11-S1-I2  0.439
2009 Lee JH, Park IH, Gao Y, Li JB, Li Z, Daley GQ, Zhang K, Church GM. A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells. Plos Genetics. 5: e1000718. PMID 19911041 DOI: 10.1371/Journal.Pgen.1000718  0.576
2009 Fuller CW, Middendorf LR, Benner SA, Church GM, Harris T, Huang X, Jovanovich SB, Nelson JR, Schloss JA, Schwartz DC, Vezenov DV. The challenges of sequencing by synthesis. Nature Biotechnology. 27: 1013-23. PMID 19898456 DOI: 10.1038/Nbt.1585  0.405
2009 Church G, Heeney C, Hawkins N, De Vries J, Boddington P, Kaye J, Bobrow M, Weir B. Public access to genome-wide data: Five views on balancing research with privacy and protection Plos Genetics. 5. PMID 19798440 DOI: 10.1371/Journal.Pgen.1000665  0.331
2009 Tolonen AC, Chilaka AC, Church GM. Targeted gene inactivation in Clostridium phytofermentans shows that cellulose degradation requires the family 9 hydrolase Cphy3367. Molecular Microbiology. 74: 1300-13. PMID 19775243 DOI: 10.1111/J.1365-2958.2009.06890.X  0.322
2009 Barak M, Levanon EY, Eisenberg E, Paz N, Rechavi G, Church GM, Mehr R. Evidence for large diversity in the human transcriptome created by Alu RNA editing. Nucleic Acids Research. 37: 6905-15. PMID 19740767 DOI: 10.1093/Nar/Gkp729  0.418
2009 Sommer MO, Dantas G, Church GM. Functional characterization of the antibiotic resistance reservoir in the human microflora. Science (New York, N.Y.). 325: 1128-31. PMID 19713526 DOI: 10.1126/Science.1176950  0.65
2009 Wang HH, Isaacs FJ, Carr PA, Sun ZZ, Xu G, Forest CR, Church GM. Programming cells by multiplex genome engineering and accelerated evolution. Nature. 460: 894-8. PMID 19633652 DOI: 10.1038/Nature08187  0.777
2009 Zhang K, Li JB, Gao Y, Egli D, Xie B, Deng J, Li Z, Lee JH, Aach J, Leproust EM, Eggan K, Church GM. Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human. Nature Methods. 6: 613-8. PMID 19620972 DOI: 10.1038/Nmeth.1357  0.643
2009 Khoury MJ, McBride CM, Schully SD, Ioannidis JP, Feero WG, Janssens AC, Gwinn M, Simons-Morton DG, Bernhardt JM, Cargill M, Chanock SJ, Church GM, Coates RJ, Collins FS, Croyle RT, et al. The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 11: 559-67. PMID 19617843 DOI: 10.1097/Gim.0B013E3181B13A6C  0.338
2009 Kim JI, Ju YS, Park H, Kim S, Lee S, Yi JH, Mudge J, Miller NA, Hong D, Bell CJ, Kim HS, Chung IS, Lee WC, Lee JS, Seo SH, ... ... Church GM, et al. A highly annotated whole-genome sequence of a Korean individual. Nature. 460: 1011-5. PMID 19587683 DOI: 10.1038/Nature08211  0.806
2009 Douglas SM, Marblestone AH, Teerapittayanon S, Vazquez A, Church GM, Shih WM. Rapid prototyping of 3D DNA-origami shapes with caDNAno. Nucleic Acids Research. 37: 5001-6. PMID 19531737 DOI: 10.1093/Nar/Gkp436  0.79
2009 Li JB, Gao Y, Aach J, Zhang K, Kryukov GV, Xie B, Ahlford A, Yoon JK, Rosenbaum AM, Zaranek AW, LeProust E, Sunyaev SR, Church GM. Multiplex padlock targeted sequencing reveals human hypermutable CpG variations. Genome Research. 19: 1606-15. PMID 19525355 DOI: 10.1101/Gr.092213.109  0.806
2009 Li JB, Levanon EY, Yoon JK, Aach J, Xie B, Leproust E, Zhang K, Gao Y, Church GM. Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing. Science (New York, N.Y.). 324: 1210-3. PMID 19478186 DOI: 10.1126/Science.1170995  0.518
2009 Friedland AE, Lu TK, Wang X, Shi D, Church G, Collins JJ. Synthetic gene networks that count. Science (New York, N.Y.). 324: 1199-202. PMID 19478183 DOI: 10.1126/Science.1172005  0.442
2009 Ball MP, Li JB, Gao Y, Lee JH, LeProust EM, Park IH, Xie B, Daley GQ, Church GM. Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nature Biotechnology. 27: 361-8. PMID 19329998 DOI: 10.1038/Nbt.1533  0.505
2009 de Magalhães JP, Budovsky A, Lehmann G, Costa J, Li Y, Fraifeld V, Church GM. The Human Ageing Genomic Resources: online databases and tools for biogerontologists. Aging Cell. 8: 65-72. PMID 18986374 DOI: 10.1111/J.1474-9726.2008.00442.X  0.33
2009 Schwartz D, Chou MF, Church GM. Predicting protein post-translational modifications using meta-analysis of proteome scale data sets. Molecular & Cellular Proteomics : McP. 8: 365-79. PMID 18974045 DOI: 10.1074/Mcp.M800332-Mcp200  0.327
2009 Ball MP, Billy Li J, Gao Y, Lee J, LeProust EM, Park I, Xie B, Daley GQ, Church GM. Erratum: Corrigendum: Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells Nature Biotechnology. 27: 485-485. DOI: 10.1038/Nbt0509-485B  0.361
2009 Douglas SM, Dietz H, Liedl T, Högberg B, Graf F, Marblestone AH, Teerapittayanon S, Vazquez A, Church GM, Shih WM. Design and self-assembly of DNA into nanoscale 3D shapes Siggraph 2009: Talks, Siggraph '09.  0.77
2008 Zaranek AW, Clegg T, Vandewege W, Church GM. Free Factories: Unified Infrastructure for Data Intensive Web Services. Proceedings of the Usenix ... Annual Technical Conference. Usenix Technical Conference. 2008: 391-404. PMID 20514356  0.712
2008 Isenbarger TA, Carr CE, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G. The most conserved genome segments for life detection on Earth and other planets. Origins of Life and Evolution of the Biosphere : the Journal of the International Society For the Study of the Origin of Life. 38: 517-33. PMID 18853276 DOI: 10.1007/S11084-008-9148-Z  0.694
2008 Snitkin ES, Dudley AM, Janse DM, Wong K, Church GM, Segrè D. Model-driven analysis of experimentally determined growth phenotypes for 465 yeast gene deletion mutants under 16 different conditions. Genome Biology. 9: R140. PMID 18808699 DOI: 10.1186/Gb-2008-9-9-R140  0.803
2008 Lunshof JE, Chadwick R, Church GM. Hippocrates revisited? Old ideals and new realities. Genomic Medicine. 2: 1-3. PMID 18716915 DOI: 10.1007/S11568-008-9020-2  0.303
2008 Dantas G, Sommer MO, Oluwasegun RD, Church GM. Bacteria subsisting on antibiotics. Science (New York, N.Y.). 320: 100-3. PMID 18388292 DOI: 10.1126/Science.1155157  0.633
2008 Lunshof JE, Chadwick R, Vorhaus DB, Church GM. From genetic privacy to open consent. Nature Reviews. Genetics. 9: 406-11. PMID 18379574 DOI: 10.1038/Nrg2360  0.38
2008 Shendure JA, Porreca GJ, Church GM. Overview of DNA sequencing strategies. Current Protocols in Molecular Biology. Unit 7.1. PMID 18231983 DOI: 10.1002/0471142727.mb0701s81  0.807
2008 Bang D, Church GM. Gene synthesis by circular assembly amplification. Nature Methods. 5: 37-9. PMID 18037891 DOI: 10.1038/Nmeth1136  0.592
2008 Church GM, Porreca GJ, Terry RC, Lares M. High-speed imaging for DNA sequencing Biophotonics International. 15: 34-36.  0.773
2008 Forest CR, Rosenbaum AM, Church GM. DNA sequencing by ligation on surfacebound beads in a microchannel environment 12th International Conference On Miniaturized Systems For Chemistry and Life Sciences - the Proceedings of Microtas 2008 Conference. 634-636.  0.742
2007 Kettler GC, Martiny AC, Huang K, Zucker J, Coleman ML, Rodrigue S, Chen F, Lapidus A, Ferriera S, Johnson J, Steglich C, Church GM, Richardson P, Chisholm SW. Patterns and implications of gene gain and loss in the evolution of Prochlorococcus. Plos Genetics. 3: e231. PMID 18159947 DOI: 10.1371/Journal.Pgen.0030231  0.406
2007 Porreca GJ, Zhang K, Li JB, Xie B, Austin D, Vassallo SL, LeProust EM, Peck BJ, Emig CJ, Dahl F, Gao Y, Church GM, Shendure J. Multiplex amplification of large sets of human exons. Nature Methods. 4: 931-6. PMID 17934468 DOI: 10.1038/Nmeth1110  0.816
2007 Lindell D, Jaffe JD, Coleman ML, Futschik ME, Axmann IM, Rector T, Kettler G, Sullivan MB, Steen R, Hess WR, Church GM, Chisholm SW. Genome-wide expression dynamics of a marine virus and host reveal features of co-evolution. Nature. 449: 83-6. PMID 17805294 DOI: 10.1038/Nature06130  0.63
2007 de Magalhães JP, Sedivy JM, Finch CE, Austad SN, Church GM. A proposal to sequence genomes of unique interest for research on aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 62: 583-4. PMID 17595413 DOI: 10.1093/Gerona/62.6.583  0.407
2007 Wright MA, Kharchenko P, Church GM, Segrè D. Chromosomal periodicity of evolutionarily conserved gene pairs. Proceedings of the National Academy of Sciences of the United States of America. 104: 10559-64. PMID 17563360 DOI: 10.1073/Pnas.0610776104  0.753
2007 Bügl H, Danner JP, Molinari RJ, Mulligan JT, Park HO, Reichert B, Roth DA, Wagner R, Budowle B, Scripp RM, Smith JA, Steele SJ, Church G, Endy D. DNA synthesis and biological security. Nature Biotechnology. 25: 627-9. PMID 17557094 DOI: 10.1038/Nbt0607-627  0.629
2007 Kim JB, Porreca GJ, Song L, Greenway SC, Gorham JM, Church GM, Seidman CE, Seidman JG. Polony multiplex analysis of gene expression (PMAGE) in mouse hypertrophic cardiomyopathy. Science (New York, N.Y.). 316: 1481-4. PMID 17556586 DOI: 10.1126/Science.1137325  0.788
2007 Forster AC, Church GM. Synthetic biology projects in vitro Genome Research. 17: 1-6. PMID 17151344 DOI: 10.1101/Gr.5776007  0.311
2006 Porreca GJ, Shendure J, Church GM. Polony DNA sequencing. Current Protocols in Molecular Biology. Unit 7.8. PMID 18265387 DOI: 10.1002/0471142727.Mb0708S76  0.823
2006 Yang A, Zhu Z, Kapranov P, McKeon F, Church GM, Gingeras TR, Struhl K. Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Molecular Cell. 24: 593-602. PMID 17188034 DOI: 10.1016/J.Molcel.2006.10.018  0.521
2006 Reppas NB, Wade JT, Church GM, Struhl K. The transition between transcriptional initiation and elongation in E. coli is highly variable and often rate limiting. Molecular Cell. 24: 747-57. PMID 17157257 DOI: 10.1016/J.Molcel.2006.10.030  0.797
2006 Derti A, Roth FP, Church GM, Wu CT. Mammalian ultraconserved elements are strongly depleted among segmental duplications and copy number variants. Nature Genetics. 38: 1216-20. PMID 16998490 DOI: 10.1038/Ng1888  0.588
2006 Lee SI, Pe'er D, Dudley AM, Church GM, Koller D. Identifying regulatory mechanisms using individual variation reveals key role for chromatin modification. Proceedings of the National Academy of Sciences of the United States of America. 103: 14062-7. PMID 16968785 DOI: 10.1073/Pnas.0601852103  0.77
2006 Forster AC, Church GM. Towards synthesis of a minimal cell Molecular Systems Biology [Electronic Resource].. 2: 45. PMID 16924266 DOI: 10.1038/Msb4100090  0.388
2006 Jaffe JD, Mani DR, Leptos KC, Church GM, Gillette MA, Carr SA. PEPPeR, a platform for experimental proteomic pattern recognition. Molecular & Cellular Proteomics : McP. 5: 1927-41. PMID 16857664 DOI: 10.1074/Mcp.M600222-Mcp200  0.778
2006 Kuo WP, Liu F, Trimarchi J, Punzo C, Lombardi M, Sarang J, Whipple ME, Maysuria M, Serikawa K, Lee SY, McCrann D, Kang J, Shearstone JR, Burke J, Park DJ, ... ... Church GM, et al. A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies. Nature Biotechnology. 24: 832-40. PMID 16823376 DOI: 10.1038/Nbt1217  0.351
2006 Zhang K, Martiny AC, Reppas NB, Barry KW, Malek J, Chisholm SW, Church GM. Sequencing genomes from single cells by polymerase cloning. Nature Biotechnology. 24: 680-6. PMID 16732271 DOI: 10.1038/Nbt1214  0.825
2006 Turner DJ, Shendure J, Porreca G, Church G, Green P, Tyler-Smith C, Hurles ME. Assaying chromosomal inversions by single-molecule haplotyping. Nature Methods. 3: 439-45. PMID 16721377 DOI: 10.1038/Nmeth881  0.539
2006 Baker D, Church G, Collins J, Endy D, Jacobson J, Keasling J, Modrich P, Smolke C, Weiss R. Engineering life: Building a FAB for biology Scientific American. 294: 44-51. PMID 16711359 DOI: 10.1038/Scientificamerican0606-44  0.688
2006 Kharchenko P, Chen L, Freund Y, Vitkup D, Church GM. Identifying metabolic enzymes with multiple types of association evidence. Bmc Bioinformatics. 7: 177. PMID 16571130 DOI: 10.1186/1471-2105-7-177  0.619
2006 Zhang K, Zhu J, Shendure J, Porreca GJ, Aach JD, Mitra RD, Church GM. Long-range polony haplotyping of individual human chromosome molecules. Nature Genetics. 38: 382-7. PMID 16493423 DOI: 10.1038/Ng1741  0.795
2006 Estrada B, Choe SE, Gisselbrecht SS, Michaud S, Raj L, Busser BW, Halfon MS, Church GM, Michelson AM. An integrated strategy for analyzing the unique developmental programs of different myoblast subtypes. Plos Genetics. 2: e16. PMID 16482229 DOI: 10.1371/Journal.Pgen.0020016  0.373
2006 Leptos KC, Sarracino DA, Jaffe JD, Krastins B, Church GM. MapQuant: open-source software for large-scale protein quantification. Proteomics. 6: 1770-82. PMID 16470651 DOI: 10.1002/Pmic.200500201  0.775
2006 Church GM. Genomes for all Scientific American.. 294: 46-54. PMID 16468433 DOI: 10.1038/Scientificamerican0106-46  0.372
2006 Church G, Shendure J, Porreca G. Sequencing thoroughbreds. Nature Biotechnology. 24: 139. PMID 16465149 DOI: 10.1038/Nbt0206-139B  0.504
2006 Nardi V, Raz T, Chao X, Wu CJ, Stone R, Galinsky I, Wadleigh M, Deininger MW, Church G, Zhu J, Daley GQ. Monitoring Imatinib Resistance with a “Polony” Assay: Towards Tailored Therapy of Chronic Myelogenous Leukemia (CML). Blood. 108: 837-837. DOI: 10.1182/Blood.V108.11.837.837  0.43
2005 Church GM. From systems biology to synthetic biology. Molecular Systems Biology. 1: 2005.0032. PMID 16729067 DOI: 10.1038/Msb4100007  0.303
2005 Church GM. The personal genome project. Molecular Systems Biology. 1: 2005.0030. PMID 16729065 DOI: 10.1038/Msb4100040  0.414
2005 Kharchenko P, Church GM, Vitkup D. Expression dynamics of a cellular metabolic network. Molecular Systems Biology. 1: 2005.0016. PMID 16729051 DOI: 10.1038/Msb4100023  0.571
2005 Dudley AM, Janse DM, Tanay A, Shamir R, Church GM. A global view of pleiotropy and phenotypically derived gene function in yeast. Molecular Systems Biology. 1: 2005.0001. PMID 16729036 DOI: 10.1038/Msb4100004  0.794
2005 Wade JT, Reppas NB, Church GM, Struhl K. Genomic analysis of LexA binding reveals the permissive nature of the Escherichia coli genome and identifies unconventional target sites. Genes & Development. 19: 2619-30. PMID 16264194 DOI: 10.1101/Gad.1355605  0.816
2005 Lindell D, Jaffe JD, Johnson ZI, Church GM, Chisholm SW. Photosynthesis genes in marine viruses yield proteins during host infection. Nature. 438: 86-9. PMID 16222247 DOI: 10.1038/Nature04111  0.586
2005 Petti AA, Church GM. A network of transcriptionally coordinated functional modules in Saccharomyces cerevisiae. Genome Research. 15: 1298-306. PMID 16109970 DOI: 10.1101/Gr.3847105  0.657
2005 Shendure J, Porreca GJ, Reppas NB, Lin X, McCutcheon JP, Rosenbaum AM, Wang MD, Zhang K, Mitra RD, Church GM. Accurate multiplex polony sequencing of an evolved bacterial genome. Science (New York, N.Y.). 309: 1728-32. PMID 16081699 DOI: 10.1126/Science.1117389  0.807
2005 Zhu Z, Shendure J, Church GM. Discovering functional transcription-factor combinations in the human cell cycle. Genome Research. 15: 848-55. PMID 15930495 DOI: 10.1101/Gr.3394405  0.646
2005 Choe SE, Boutros M, Michelson AM, Church GM, Halfon MS. Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset. Genome Biology. 6: R16. PMID 15693945 DOI: 10.1186/Gb-2005-6-2-R16  0.31
2005 Tompa M, Li N, Bailey TL, Church GM, De Moor B, Eskin E, Favorov AV, Frith MC, Fu Y, Kent WJ, Makeev VJ, Mironov AA, Noble WS, Pavesi G, Pesole G, et al. Assessing computational tools for the discovery of transcription factor binding sites. Nature Biotechnology. 23: 137-44. PMID 15637633 DOI: 10.1038/Nbt1053  0.448
2005 Segrè D, Deluna A, Church GM, Kishony R. Modular epistasis in yeast metabolism. Nature Genetics. 37: 77-83. PMID 15592468 DOI: 10.1038/Ng1489  0.617
2004 Tian J, Gong H, Sheng N, Zhou X, Gulari E, Gao X, Church G. Accurate multiplex gene synthesis from programmable DNA microchips. Nature. 432: 1050-4. PMID 15616567 DOI: 10.1038/Nature03151  0.402
2004 Feingold EA, Good PJ, Guyer MS, Kamholz S, Liefer L, Wetterstrand K, Collins FS, Gingeras TR, Kampa D, Sekinger EA, Cheng J, Hirsch H, Ghosh S, Zhu Z, Patel S, ... ... Church G, et al. The ENCODE (ENCyclopedia of DNA Elements) Project Science. 306: 636-640. PMID 15499007 DOI: 10.1126/Science.1105136  0.721
2004 Grainger DC, Overton TW, Reppas N, Wade JT, Tamai E, Hobman JL, Constantinidou C, Struhl K, Church G, Busby SJW. Genomic studies with Escherichia coli MelR protein: Applications of chromatin immunoprecipitation and microarrays Journal of Bacteriology. 186: 6938-6943. PMID 15466047 DOI: 10.1128/Jb.186.20.6938-6943.2004  0.803
2004 Jaffe JD, Stange-Thomann N, Smith C, DeCaprio D, Fisher S, Butler J, Calvo S, Elkins T, FitzGerald MG, Hafez N, Kodira CD, Major J, Wang S, Wilkinson J, Nicol R, ... ... Church GM, et al. The complete genome and proteome of Mycoplasma mobile. Genome Research. 14: 1447-61. PMID 15289470 DOI: 10.1101/Gr.2674004  0.669
2004 Kharchenko P, Vitkup D, Church GM. Filling gaps in a metabolic network using expression information. Bioinformatics (Oxford, England). 20: i178-85. PMID 15262797 DOI: 10.1093/bioinformatics/bth930  0.529
2004 Grad YH, Roth FP, Halfon MS, Church GM. Prediction of similarly acting cis-regulatory modules by subsequence profiling and comparative genomics in Drosophila melanogaster and D.pseudoobscura. Bioinformatics (Oxford, England). 20: 2738-50. PMID 15145800 DOI: 10.1093/Bioinformatics/Bth320  0.713
2004 Shendure J, Mitra RD, Varma C, Church GM. Advanced sequencing technologies: methods and goals. Nature Reviews. Genetics. 5: 335-44. PMID 15143316 DOI: 10.1038/Nrg1325  0.491
2004 Mikkilineni V, Mitra RD, Merritt J, DiTonno JR, Church GM, Ogunnaike B, Edwards JS. Digital quantitative measurements of gene expression. Biotechnology and Bioengineering. 86: 117-24. PMID 15052631 DOI: 10.1002/Bit.20048  0.358
2004 Janse DM, Crosas B, Finley D, Church GM. Localization to the proteasome is sufficient for degradation. The Journal of Biological Chemistry. 279: 21415-20. PMID 15039430 DOI: 10.1074/Jbc.M402954200  0.771
2004 Bulyk ML, McGuire AM, Masuda N, Church GM. A motif co-occurrence approach for genome-wide prediction of transcription-factor-binding sites in Escherichia coli. Genome Research. 14: 201-8. PMID 14762058 DOI: 10.1101/Gr.1448004  0.778
2004 Jaffe JD, Berg HC, Church GM. Proteogenomic mapping as a complementary method to perform genome annotation. Proteomics. 4: 59-77. PMID 14730672 DOI: 10.1002/Pmic.200300511  0.648
2004 Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proceedings of the National Academy of Sciences of the United States of America. 101: 360-5. PMID 14691248 DOI: 10.1073/Pnas.2333854100  0.639
2004 Lelandais G, Le Crom S, Devaux F, Vialette S, Church GM, Jacq C, Marc P. yMGV: a cross-species expression data mining tool. Nucleic Acids Research. 32: D323-5. PMID 14681424 DOI: 10.1093/Nar/Gkh135  0.79
2004 Mitra RD, Shendure J, Olejnik J, Church GM. CorrigendumErratum to “Fluorescent in situ sequencing on polymerase colonies” [Anal. Biochem. 320 (2003) 55–65] Analytical Biochemistry. 328: 245. DOI: 10.1016/J.Ab.2004.03.002  0.508
2003 Segrè D, Zucker J, Katz J, Lin X, D'haeseleer P, Rindone WP, Kharchenko P, Nguyen DH, Wright MA, Church GM. From annotated genomes to metabolic flux models and kinetic parameter fitting. Omics : a Journal of Integrative Biology. 7: 301-16. PMID 14583118 DOI: 10.1089/153623103322452413  0.739
2003 Zhu J, Shendure J, Mitra RD, Church GM. Single molecule profiling of alternative pre-mRNA splicing. Science (New York, N.Y.). 301: 836-8. PMID 12907803 DOI: 10.1126/Science.1085792  0.504
2003 Mitra RD, Shendure J, Olejnik J, Edyta-Krzymanska-Olejnik, Church GM. Fluorescent in situ sequencing on polymerase colonies. Analytical Biochemistry. 320: 55-65. PMID 12895469 DOI: 10.1016/S0003-2697(03)00291-4  0.558
2003 Merritt J, DiTonno JR, Mitra RD, Church GM, Edwards JS. Parallel competition analysis of Saccharomyces cerevisiae strains differing by a single base using polymerase colonies. Nucleic Acids Research. 31: e84. PMID 12888536 DOI: 10.1093/Nar/Gng084  0.333
2003 King OD, Lee JC, Dudley AM, Janse DM, Church GM, Roth FP. Predicting phenotype from patterns of annotation. Bioinformatics (Oxford, England). 19: i183-9. PMID 12855456 DOI: 10.1093/Bioinformatics/Btg1024  0.768
2003 Selinger DW, Wright MA, Church GM. On the complete determination of biological systems. Trends in Biotechnology. 21: 251-4. PMID 12788544 DOI: 10.1016/S0167-7799(03)00113-6  0.771
2003 Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J. Computational and experimental identification of C. elegans microRNAs. Molecular Cell. 11: 1253-63. PMID 12769849 DOI: 10.1016/S1097-2765(03)00153-9  0.67
2003 Mitra RD, Butty VL, Shendure J, Williams BR, Housman DE, Church GM. Digital genotyping and haplotyping with polymerase colonies. Proceedings of the National Academy of Sciences of the United States of America. 100: 5926-31. PMID 12730373 DOI: 10.1073/Pnas.0936399100  0.504
2003 Masuda N, Church GM. Regulatory network of acid resistance genes in Escherichia coli. Molecular Microbiology. 48: 699-712. PMID 12694615 DOI: 10.1046/J.1365-2958.2003.03477.X  0.3
2003 Selinger DW, Saxena RM, Cheung KJ, Church GM, Rosenow C. Global RNA half-life analysis in Escherichia coli reveals positional patterns of transcript degradation. Genome Research. 13: 216-23. PMID 12566399 DOI: 10.1101/Gr.912603  0.785
2003 Cheung KJ, Badarinarayana V, Selinger DW, Janse D, Church GM. A microarray-based antibiotic screen identifies a regulatory role for supercoiling in the osmotic stress response of Escherichia coli. Genome Research. 13: 206-15. PMID 12566398 DOI: 10.1101/Gr.401003  0.783
2003 Anderson LM, Choe SE, Yukhananov RY, Hopfner RL, Church GM, Pratt RE, Dzau VJ. Identification of a novel set of genes regulated by a unique liver X receptor-alpha -mediated transcription mechanism. The Journal of Biological Chemistry. 278: 15252-60. PMID 12551904 DOI: 10.1074/Jbc.M208644200  0.325
2002 Lee ML, Bulyk ML, Whitmore GA, Church GM. A statistical model for investigating binding probabilities of DNA nucleotide sequences using microarrays. Biometrics. 58: 981-8. PMID 12495153 DOI: 10.1111/J.0006-341X.2002.00981.X  0.606
2002 Sudarsanam P, Pilpel Y, Church GM. Genome-wide co-occurrence of promoter elements reveals a cis-regulatory cassette of rRNA transcription motifs in Saccharomyces cerevisiae. Genome Research. 12: 1723-31. PMID 12421759 DOI: 10.1101/Gr.301202  0.413
2002 Segrè D, Vitkup D, Church GM. Analysis of optimality in natural and perturbed metabolic networks. Proceedings of the National Academy of Sciences of the United States of America. 99: 15112-7. PMID 12415116 DOI: 10.1073/Pnas.232349399  0.604
2002 Steffen M, Petti A, Aach J, D'haeseleer P, Church G. Automated modelling of signal transduction networks. Bmc Bioinformatics. 3: 34. PMID 12413400 DOI: 10.1186/1471-2105-3-34  0.638
2002 Shendure J, Church GM. Computational discovery of sense-antisense transcription in the human and mouse genomes. Genome Biology. 3: RESEARCH0044. PMID 12225583 DOI: 10.1186/Gb-2002-3-9-Research0044  0.574
2002 Schilling CH, Covert MW, Famili I, Church GM, Edwards JS, Palsson BO. Genome-scale metabolic model of Helicobacter pylori 26695. Journal of Bacteriology. 184: 4582-93. PMID 12142428 DOI: 10.1128/Jb.184.16.4582-4593.2002  0.524
2002 Halfon MS, Grad Y, Church GM, Michelson AM. Computation-based discovery of related transcriptional regulatory modules and motifs using an experimentally validated combinatorial model. Genome Research. 12: 1019-28. PMID 12097338 DOI: 10.1101/gr.228902  0.574
2002 Zhu Z, Pilpel Y, Church GM. Computational identification of transcription factor binding sites via a transcription-factor-centric clustering (TFCC) algorithm. Journal of Molecular Biology. 318: 71-81. PMID 12054769 DOI: 10.1016/S0022-2836(02)00026-8  0.474
2002 Dudley AM, Aach J, Steffen MA, Church GM. Measuring absolute expression with microarrays with a calibrated reference sample and an extended signal intensity range. Proceedings of the National Academy of Sciences of the United States of America. 99: 7554-9. PMID 12032321 DOI: 10.1073/Pnas.112683499  0.675
2002 Cohen BA, Pilpel Y, Mitra RD, Church GM. Discrimination between paralogs using microarray analysis: application to the Yap1p and Yap2p transcriptional networks. Molecular Biology of the Cell. 13: 1608-14. PMID 12006656 DOI: 10.1091/Mbc.01-10-0472  0.371
2002 Bulyk ML, Johnson PL, Church GM. Nucleotides of transcription factor binding sites exert interdependent effects on the binding affinities of transcription factors. Nucleic Acids Research. 30: 1255-61. PMID 11861919 DOI: 10.1093/Nar/30.5.1255  0.565
2002 Weber G, Shendure J, Tanenbaum DM, Church GM, Meyerson M. Identification of foreign gene sequences by transcript filtering against the human genome. Nature Genetics. 30: 141-2. PMID 11788827 DOI: 10.1038/Ng818  0.561
2001 Chen T, Jaffe JD, Church GM. Algorithms for identifying protein cross-links via tandem mass spectrometry. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 8: 571-83. PMID 11747613 DOI: 10.1089/106652701753307494  0.538
2001 Ge H, Liu Z, Church GM, Vidal M. Correlation between transcriptome and interactome mapping data from Saccharomyces cerevisiae. Nature Genetics. 29: 482-6. PMID 11694880 DOI: 10.1038/Ng776  0.404
2001 Badarinarayana V, Estep PW, Shendure J, Edwards J, Tavazoie S, Lam F, Church GM. Selection analyses of insertional mutants using subgenic-resolution arrays. Nature Biotechnology. 19: 1060-5. PMID 11689852 DOI: 10.1038/Nbt1101-1060  0.815
2001 Pilpel Y, Sudarsanam P, Church GM. Identifying regulatory networks by combinatorial analysis of promoter elements. Nature Genetics. 29: 153-9. PMID 11547334 DOI: 10.1038/Ng724  0.331
2001 Bulyk ML, Huang X, Choo Y, Church GM. Exploring the DNA-binding specificities of zinc fingers with DNA microarrays. Proceedings of the National Academy of Sciences of the United States of America. 98: 7158-63. PMID 11404456 DOI: 10.1073/Pnas.111163698  0.627
2001 Jamshidi N, Edwards JS, Fahland T, Church GM, Palsson BO. Dynamic simulation of the human red blood cell metabolic network. Bioinformatics (Oxford, England). 17: 286-7. PMID 11294796 DOI: 10.1093/Bioinformatics/17.3.286  0.412
2001 Aach J, Bulyk ML, Church GM, Comander J, Derti A, Shendure J. Computational comparison of two draft sequences of the human genome. Nature. 409: 856-9. PMID 11237010 DOI: 10.1038/35057055  0.708
2000 Selinger DW, Cheung KJ, Mei R, Johansson EM, Richmond CS, Blattner FR, Lockhart DJ, Church GM. RNA expression analysis using a 30 base pair resolution Escherichia coli genome array. Nature Biotechnology. 18: 1262-8. PMID 11101804 DOI: 10.1038/82367  0.8
2000 Hoehe MR, Köpke K, Wendel B, Rohde K, Flachmeier C, Kidd KK, Berrettini WH, Church GM. Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence. Human Molecular Genetics. 9: 2895-908. PMID 11092766 DOI: 10.1093/Hmg/9.19.2895  0.378
2000 Goldmark JP, Fazzio TG, Estep PW, Church GM, Tsukiyama T. The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p. Cell. 103: 423-33. PMID 11081629 DOI: 10.1016/S0092-8674(00)00134-3  0.762
2000 McGuire AM, Church GM. Predicting regulons and their cis-regulatory motifs by comparative genomics Nucleic Acids Research. 28: 4523-4530. PMID 11071941 DOI: 10.1093/Nar/28.22.4523  0.73
2000 Jelinsky SA, Estep P, Church GM, Samson LD. Regulatory networks revealed by transcriptional profiling of damaged Saccharomyces cerevisiae cells: Rpn4 links base excision repair with proteasomes. Molecular and Cellular Biology. 20: 8157-67. PMID 11027285 DOI: 10.1128/Mcb.20.21.8157-8167.2000  0.789
2000 Cohen BA, Mitra RD, Hughes JD, Church GM. A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression. Nature Genetics. 26: 183-6. PMID 11017073 DOI: 10.1038/79896  0.581
2000 McGuire AM, Hughes JD, Church GM. Conservation of DNA regulatory motifs and discovery of new motifs in microbial genomes. Genome Research. 10: 744-57. PMID 10854408 DOI: 10.1101/Gr.10.6.744  0.797
2000 Teichmann SA, Chothia C, Church GM, Park J. Fast assignment of protein structures to sequences using the intermediate sequence library PDB-ISL. Bioinformatics (Oxford, England). 16: 117-24. PMID 10842732 DOI: 10.1093/Bioinformatics/16.2.117  0.363
2000 Aach J, Rindone W, Church GM. Systematic management and analysis of yeast gene expression data. Genome Research. 10: 431-45. PMID 10779484 DOI: 10.1101/Gr.10.4.431  0.332
2000 Livesey FJ, Furukawa T, Steffen MA, Church GM, Cepko CL. Microarray analysis of the transcriptional network controlled by the photoreceptor homeobox gene Crx. Current Biology : Cb. 10: 301-10. PMID 10744971 DOI: 10.1016/S0960-9822(00)00379-1  0.323
2000 Hughes JD, Estep PW, Tavazoie S, Church GM. Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae. Journal of Molecular Biology. 296: 1205-14. PMID 10698627 DOI: 10.1006/Jmbi.2000.3519  0.814
1999 Mitra RD, Church GM. In situ localized amplification and contact replication of many individual DNA molecules Nucleic Acids Research. 27: e34. PMID 10572186 DOI: 10.1093/Nar/27.24.E34  0.325
1999 Tavazoie S, Hughes JD, Campbell MJ, Cho RJ, Church GM. Systematic determination of genetic network architecture. Nature Genetics. 22: 281-5. PMID 10391217 DOI: 10.1038/10343  0.736
1999 Bulyk ML, Gentalen E, Lockhart DJ, Church GM. Quantifying DNA-protein interactions by double-stranded DNA arrays. Nature Biotechnology. 17: 573-7. PMID 10385322 DOI: 10.1038/9878  0.62
1999 McGuire AM, De Wulf P, Church GM, Lin EC. A weight matrix for binding recognition by the redox-response regulator ArcA-P of Escherichia coli. Molecular Microbiology. 32: 219-21. PMID 10216875 DOI: 10.1046/J.1365-2958.1999.01347.X  0.656
1999 Steffen M, Mitra R, Huang X, Aach J, Church G. Surface attachment chemistry for in situ probe DNA amplification Nature Genetics. 23: 75-76. DOI: 10.1038/14408  0.314
1998 Robison K, McGuire AM, Church GM. A comprehensive library of DNA-binding site matrices for 55 proteins applied to the complete Escherichia coli K-12 genome. Journal of Molecular Biology. 284: 241-54. PMID 9813115 DOI: 10.1006/Jmbi.1998.2160  0.733
1998 Roth FP, Hughes JD, Estep PW, Church GM. Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation. Nature Biotechnology. 16: 939-45. PMID 9788350 DOI: 10.1038/Nbt1098-939  0.818
1998 Church GM. Databases for gene expression. Nature Biotechnology. 14: 828. PMID 9631002 DOI: 10.1038/Nbt0796-828A  0.32
1998 Tavazoie S, Church GM. Quantitative whole-genome analysis of DNA-protein interactions by in vivo methylase protection in E. coli. Nature Biotechnology. 16: 566-71. PMID 9624689 DOI: 10.1038/Nbt0698-566  0.656
1997 Link AJ, Phillips D, Church GM. Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization. Journal of Bacteriology. 179: 6228-37. PMID 9335267 DOI: 10.1128/Jb.179.20.6228-6237.1997  0.638
1997 Link AJ, Robison K, Church GM. Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12. Electrophoresis. 18: 1259-313. PMID 9298646 DOI: 10.1002/Elps.1150180807  0.635
1997 Xu L, Bian N, Wang Z, Abdel-Baky S, Pillai S, Magiera D, Murugaiah V, Giese RW, Wang P, O'Keeffe T, Abushamaa H, Kutney L, Church G, Carson S, Smith D, et al. Electrophore Mass Tag Dideoxy DNA Sequencing Analytical Chemistry. 69: 3595-3602. PMID 9286165 DOI: 10.1021/Ac970066L  0.322
1997 Smith DR, Richterich P, Rubenfield M, Rice PW, Butler C, Lee HM, Kirst S, Gundersen K, Abendschan K, Xu Q, Chung M, Deloughery C, Aldredge T, Maher J, Lundstrom R, ... ... Church GM, et al. Multiplex sequencing of 1.5 Mb of the Mycobacterium leprae genome. Genome Research. 7: 802-19. PMID 9267804 DOI: 10.1101/Gr.7.8.802  0.428
1996 Robison K, Gilbert W, Church GM. More haemophilus and Mycoplasma genes. Science (New York, N.Y.). 271: 1302b-3b. PMID 17820934 DOI: 10.1126/Science.271.5253.1302A  0.498
1996 Robison K, Gilbert W, Church GM. More Haemophilus and Mycoplasma genes. Science (New York, N.Y.). 271: 1302-3; author reply. PMID 8638118  0.433
1995 Richterich P, Lakey ND, Lee HM, Mao JI, Smith D, Church GM. Cytosine specific DNA sequencing with hydrogen peroxide. Nucleic Acids Research. 23: 4922-3. PMID 8532538 DOI: 10.1093/Nar/23.23.4922  0.317
1994 Robison K, Gilbert W, Church GM. Large scale bacterial gene discovery by similarity search. Nature Genetics. 7: 205-14. PMID 7920643 DOI: 10.1038/Ng0694-205  0.58
1993 Richterich P, Church GM. DNA sequencing with direct transfer electrophoresis and nonradioactive detection. Methods in Enzymology. 218: 187-222. PMID 8510533 DOI: 10.1016/0076-6879(93)18016-6  0.353
1993 Roth JR, Lawrence JG, Rubenfield M, Kieffer-Higgins S, Church GM. Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium Journal of Bacteriology. 175: 3303-3316. PMID 8501034 DOI: 10.1128/Jb.175.11.3303-3316.1993  0.344
1993 Wang MX, Church GM. A whole genome approach to in vivo DNA-protein interactions in E. coli. Nature. 360: 606-10. PMID 1334233 DOI: 10.1038/360606A0  0.442
1992 Sikorav JL, Church GM. Complementary recognition in condensed DNA: accelerated DNA renaturation. Journal of Molecular Biology. 222: 1085-108. PMID 1837060 DOI: 10.1016/0022-2836(91)90595-W  0.312
1988 Church GM, Kieffer-Higgins S. Multiplex DNA sequencing. Science (New York, N.Y.). 240: 185-8. PMID 3353714 DOI: 10.1126/Science.3353714  0.342
1985 Church GM, Ephrussi A, Gilbert W, Tonegawa S. Cell-type-specific contacts to immunoglobulin enhancers in nuclei. Nature. 313: 798-801. PMID 3919308 DOI: 10.1038/313798A0  0.585
1985 Ephrussi A, Church GM, Tonegawa S, Gilbert W. B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science (New York, N.Y.). 227: 134-40. PMID 3917574 DOI: 10.1126/Science.3917574  0.554
1985 Church GM, Gilbert W. The genomic sequencing technique. Progress in Clinical and Biological Research. 177: 17-21. PMID 2989835  0.508
1984 Church GM, Gilbert W. Genomic sequencing. Proceedings of the National Academy of Sciences of the United States of America. 81: 1991-5. PMID 6326095 DOI: 10.1073/Pnas.81.7.1991  0.604
1979 Church GM, Slonimski PP, Gilbert W. Pleiotropic mutations within two yeast mitochondrial cytochrome genes block mRNA processing. Cell. 18: 1209-15. PMID 229970 DOI: 10.1016/0092-8674(79)90233-2  0.514
1978 Sutcliffe JG, Church GM. The cleavage site of the restriction endonuclease Ava II. Nucleic Acids Research. 5: 2313-9. PMID 97636 DOI: 10.1093/Nar/5.7.2313  0.48
1977 Holbrook SR, Sussman JL, Warrant RW, Church GM, Kim SH. RNA-ligant interactions. (I) Magnesium binding sites in yeast tRNAPhe. Nucleic Acids Research. 4: 2811-20. PMID 333395 DOI: 10.1093/Nar/4.8.2811  0.497
1977 Church GM, Sussman JL, Kim SH. Secondary structural complementarity between DNA and proteins. Proceedings of the National Academy of Sciences of the United States of America. 74: 1458-62. PMID 266187 DOI: 10.1073/Pnas.74.4.1458  0.532
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