| Year |
Citation |
Score |
| 2023 |
Vuksanovic N, Melkonian TR, Serrano DA, Schwabacher AW, Silvaggi NR. Structural and Biochemical Characterization of MppQ, an L-Enduracididine Biosynthetic Enzyme from . Biochemistry. 62: 3105-3115. PMID 37890134 DOI: 10.1021/acs.biochem.3c00428 |
0.744 |
|
| 2023 |
Melkonian TR, Vuksanovic N, Silvaggi NR. Probing mechanistic questions in the PLP- and O-dependent l-Arg oxidases. Methods in Enzymology. 685: 493-529. PMID 37245913 DOI: 10.1016/bs.mie.2023.03.010 |
0.733 |
|
| 2022 |
Johnston N, Samuels TL, Goetz CJ, Arnold LA, Smith BC, Seabloom D, Wuertz B, Ondrey F, Wiedmann TS, Vuksanovic N, Silvaggi NR, MacKinnon AC, Miller J, Bock J, Blumin JH. Oral and Inhaled Fosamprenavir Reverses Pepsin-Induced Damaged in a Laryngopharyngeal Reflux Mouse Model. The Laryngoscope. PMID 35678265 DOI: 10.1002/lary.30242 |
0.701 |
|
| 2021 |
Turner LD, Nielsen AL, Lin L, Campedelli AJ, Silvaggi NR, Chen JS, Wakefield AE, Allen KN, Janda KD. Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease. Acs Medicinal Chemistry Letters. 12: 1318-1324. PMID 34413962 DOI: 10.1021/acsmedchemlett.1c00325 |
0.574 |
|
| 2020 |
Virdi RS, Bavisotto RV, Hopper NC, Vuksanovic N, Melkonian TR, Silvaggi NR, Frick DN. Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3. Slas Discovery : Advancing Life Sciences R & D. 2472555220960428. PMID 32981460 DOI: 10.1177/2472555220960428 |
0.715 |
|
| 2020 |
Vuksanovic N, Zhu X, Serrano DA, Siitonen V, Metsä-Ketelä M, Melançon CE, Silvaggi NR. Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis. Acta Crystallographica. Section F, Structural Biology Communications. 76: 372-383. PMID 32744249 DOI: 10.1107/S2053230X20009814 |
0.734 |
|
| 2020 |
Frick DN, Virdi RS, Vuksanovic N, Dahal N, Silvaggi NR. Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3. Biochemistry. PMID 32578982 DOI: 10.1021/Acs.Biochem.0C00309 |
0.727 |
|
| 2019 |
Han L, Vuksanovic N, Oehm SA, Fenske TG, Schwabacher AW, Silvaggi NR. Correction to " MppP is a PLP-Dependent Oxidase, Not an Oxygenase". Biochemistry. PMID 31790219 DOI: 10.1021/Acs.Biochem.9B00994 |
0.705 |
|
| 2019 |
Mydy L, Hoppe RW, Hagemann TM, Schwabacher AW, Silvaggi N. Mechanistic Studies of the Streptomyces bingchenggensis Aldolase-Dehydratase: Implications for Substrate and Reaction Specificity in the Acetoacetate Decarboxylase-Like Superfamily. Biochemistry. PMID 31524380 DOI: 10.1021/Acs.Biochem.9B00652 |
0.393 |
|
| 2019 |
Roman JV, Melkonian TR, Silvaggi N, Moran GR. Transient State Analysis of Human Isocitrate Dehydrogenase I: Accounting for the Interconversion of Active and Non-Active Conformational States. Biochemistry. PMID 31478653 DOI: 10.1021/Acs.Biochem.9B00518 |
0.384 |
|
| 2018 |
Han L, Vuksanovic N, Oehm SA, Fenske TG, Schwabacher AW, Silvaggi N. Streptomyces wadayamensis MppP is a PLP-dependent oxidase, not an oxygenase. Biochemistry. PMID 29473729 DOI: 10.1021/Acs.Biochem.8B00130 |
0.75 |
|
| 2017 |
Mydy LS, Mashhadi Z, Knight TW, Fenske T, Hagemann T, Hoppe RW, Han L, Miller TR, Schwabacher AW, Silvaggi NR. Swit_4259, an acetoacetate decarboxylase-like enzyme from Sphingomonas wittichii RW1. Acta Crystallographica. Section F, Structural Biology Communications. 73: 672-681. PMID 29199988 DOI: 10.1107/S2053230X17015862 |
0.389 |
|
| 2017 |
Jacobson AR, Adler M, Silvaggi NR, Allen KN, Smith GM, Fredenburg RA, Stein RL, Park JB, Feng X, Shoemaker CB, Deshpande SS, Goodnough MC, Malizio CJ, Johnson EA, Pellett S, et al. Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A. Toxicon : Official Journal of the International Society On Toxinology. PMID 28698055 DOI: 10.1016/J.Toxicon.2017.06.016 |
0.568 |
|
| 2016 |
Beaupre BA, Roman JV, Hoag MR, Meneely KM, Silvaggi NR, Lamb AL, Moran GR. Ligand binding phenomena that pertain to the metabolic function of renalase. Archives of Biochemistry and Biophysics. PMID 27769837 DOI: 10.1016/J.Abb.2016.10.011 |
0.378 |
|
| 2015 |
Han L, Schwabacher AW, Moran GR, Silvaggi NR. Streptomyces wadayamensis MppP is a PLP-Dependent L-Arginine α-deaminase, γ-Hydroxylase in the Enduracididine Biosynthetic Pathway. Biochemistry. PMID 26551990 DOI: 10.1021/Acs.Biochem.5B01016 |
0.452 |
|
| 2015 |
Mueller LS, Hoppe RW, Ochsenwald JM, Berndt RT, Severin GB, Schwabacher AW, Silvaggi NR. Sbi00515, a Protein of Unknown Function from Streptomyces bingchenggensis, Highlights the Functional Versatility of the Acetoacetate Decarboxylase Scaffold. Biochemistry. 54: 3978-88. PMID 26039798 DOI: 10.1021/Acs.Biochem.5B00483 |
0.423 |
|
| 2015 |
Hoag MR, Roman J, Beaupre BA, Silvaggi NR, Moran GR. Bacterial Renalase: Structure and Kinetics of an Enzyme with 2- and 6-Dihydro-β-NAD(P) Oxidase Activity from Pseudomonas phaseolicola. Biochemistry. 54: 3791-802. PMID 26016690 DOI: 10.1021/Acs.Biochem.5B00451 |
0.387 |
|
| 2014 |
Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle DD, Arnold LA. Anticancer activity of VDR-coregulator inhibitor PS121912. Cancer Chemotherapy and Pharmacology. 74: 787-98. PMID 25107568 DOI: 10.1007/S00280-014-2549-Y |
0.308 |
|
| 2013 |
Burroughs AM, Hoppe RW, Goebel NC, Sayyed BH, Voegtline TJ, Schwabacher AW, Zabriskie TM, Silvaggi NR. Structural and functional characterization of MppR, an enduracididine biosynthetic enzyme from streptomyces hygroscopicus: Functional diversity in the acetoacetate decarboxylase-like superfamily Biochemistry. 52: 4492-4506. PMID 23758195 DOI: 10.1021/Bi400397K |
0.431 |
|
| 2013 |
Šilhár P, Silvaggi NR, Pellett S, Čapková K, Johnson EA, Allen KN, Janda KD. Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies. Bioorganic & Medicinal Chemistry. 21: 1344-8. PMID 23340139 DOI: 10.1016/J.Bmc.2012.12.001 |
0.591 |
|
| 2011 |
Toteva MM, Silvaggi NR, Allen KN, Richard JP. Binding energy and catalysis by d -xylose isomerase: Kinetic, product, and X-ray Crystallographic analysis of enzyme-catalyzed isomerization of (R)-glyceraldehyde Biochemistry. 50: 10170-10181. PMID 21995300 DOI: 10.1021/Bi201378C |
0.552 |
|
| 2010 |
Stowe GN, Silhár P, Hixon MS, Silvaggi NR, Allen KN, Moe ST, Jacobson AR, Barbieri JT, Janda KD. Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease. Organic Letters. 12: 756-9. PMID 20092262 DOI: 10.1021/Ol902820Z |
0.582 |
|
| 2008 |
Silvaggi NR, Wilson D, Tzipori S, Allen KN. Catalytic features of the botulinum neurotoxin A light chain revealed by high resolution structure of an inhibitory peptide complex Biochemistry. 47: 5736-5745. PMID 18457419 DOI: 10.1021/Bi8001067 |
0.611 |
|
| 2007 |
Silvaggi NR, Boldt GE, Hixon MS, Kennedy JP, Tzipori S, Janda KD, Allen KN. Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility. Chemistry & Biology. 14: 533-42. PMID 17524984 DOI: 10.1016/J.Chembiol.2007.03.014 |
0.63 |
|
| 2007 |
Silvaggi NR, Martin LJ, Schwalbe H, Imperiali B, Allen KN. Double-lanthanide-binding tags for macromolecular crystallographic structure determination. Journal of the American Chemical Society. 129: 7114-20. PMID 17497863 DOI: 10.1021/Ja070481N |
0.585 |
|
| 2007 |
Martin LJ, Hähnke MJ, Nitz M, Wöhnert J, Silvaggi NR, Allen KN, Schwalbe H, Imperiali B. Double-lanthanide-binding tags: design, photophysical properties, and NMR applications. Journal of the American Chemical Society. 129: 7106-13. PMID 17497862 DOI: 10.1021/Ja070480V |
0.593 |
|
| 2006 |
Silvaggi NR, Zhang C, Lu Z, Dai J, Dunaway-Mariano D, Allen KN. The X-ray crystal structures of human α-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a Journal of Biological Chemistry. 281: 14918-14926. PMID 16540464 DOI: 10.1074/Jbc.M601505200 |
0.564 |
|
| 2005 |
Llinás A, Ahmed N, Cordaro M, Laws AP, Frère JM, Delmarcelle M, Silvaggi NR, Kelly JA, Page MI. Inactivation of bacterial DD-peptidase by beta-sultams. Biochemistry. 44: 7738-46. PMID 15909988 DOI: 10.1021/Bi050110O |
0.609 |
|
| 2005 |
Silvaggi NR, Josephine HR, Kuzin AP, Nagarajan R, Pratt RF, Kelly JA. Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin". Journal of Molecular Biology. 345: 521-33. PMID 15581896 DOI: 10.1016/J.Jmb.2004.10.076 |
0.604 |
|
| 2004 |
Silvaggi NR, Kaur K, Adediran SA, Pratt RF, Kelly JA. Toward better antibiotics: crystallographic studies of a novel class of DD-peptidase/beta-lactamase inhibitors. Biochemistry. 43: 7046-53. PMID 15170342 DOI: 10.1021/Bi049612C |
0.64 |
|
| 2003 |
Silvaggi NR, Anderson JW, Brinsmade SR, Pratt RF, Kelly JA. The crystal structure of phosphonate-inhibited D-Ala-D-Ala peptidase reveals an analogue of a tetrahedral transition state. Biochemistry. 42: 1199-208. PMID 12564922 DOI: 10.1021/Bi0268955 |
0.65 |
|
| 2002 |
McDonough MA, Anderson JW, Silvaggi NR, Pratt RF, Knox JR, Kelly JA. Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins. Journal of Molecular Biology. 322: 111-22. PMID 12215418 DOI: 10.1016/S0022-2836(02)00742-8 |
0.66 |
|
| 2002 |
Kelly JA, Brinsmade SR, Silvaggi NR. Trapping reaction intermediates: a transition state on the R61 DD-peptidase catalytic pathway Acta Crystallographica Section a Foundations of Crystallography. 58: c103-c103. DOI: 10.1107/S0108767302089146 |
0.498 |
|
| 2001 |
Lee W, McDonough MA, Kotra LP, Li ZH, Silvaggi NR, Takeda Y, Kelly JA, Mobashery S. A 1.2-Å snapshot of the final step of bacterial cell wall biosynthesis Proceedings of the National Academy of Sciences of the United States of America. 98: 1427-1431. PMID 11171967 DOI: 10.1073/Pnas.98.4.1427 |
0.632 |
|
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