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Arun K. Ghosh - Publications

Affiliations: 
Purdue University, West Lafayette, IN, United States 
Area:
HIV-1 protease inhibitors
Website:
http://www.chem.purdue.edu/ghosh/
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Year Citation  Score
2024 Ghosh AK, Yadav M, Iddum S, Ghazi S, Lendy EK, Jayashankar U, Beechboard SN, Takamatsu Y, Hattori SI, Aamano M, Higashi-Kuwata N, Mitsuya H, Mesecar AD. Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors. European Journal of Medicinal Chemistry. 267: 116132. PMID 38335815 DOI: 10.1016/j.ejmech.2024.116132  0.316
2023 Ghosh AK, Yadav M. Synthesis of optically active SARS-CoV-2 Mpro inhibitor drug nirmatrelvir (Paxlovid): an approved treatment of COVID-19. Organic & Biomolecular Chemistry. 21: 5768-5774. PMID 37293830 DOI: 10.1039/d3ob00653k  0.339
2023 Ghosh AK, Harper M, Robinson WL. Total Synthesis of Neuroprotective Agents, (+)-Lycibarbarine A and (-)-Lycibarbarine B. The Journal of Organic Chemistry. PMID 37267592 DOI: 10.1021/acs.joc.3c00749  0.309
2023 Ghosh AK, Mishevich JL, Kovela S, Shaktah R, Ghosh AK, Johnson M, Wang YF, Wong-Sam A, Agniswamy J, Amano M, Takamatsu Y, Hattori SI, Weber IT, Mitsuya H. Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation. European Journal of Medicinal Chemistry. 255: 115385. PMID 37150084 DOI: 10.1016/j.ejmech.2023.115385  0.436
2023 Ghosh AK, Shahabi D, Kipfmiller M, Ghosh AK, Johnson M, Wang YF, Agniswamy J, Amano M, Weber IT, Mitsuya H. Evaluation of Darunavir-derived HIV-1 protease inhibitors incorporating P2' amide-derivatives: Synthesis, biological evaluation and structural studies. Bioorganic & Medicinal Chemistry Letters. 129168. PMID 36738797 DOI: 10.1016/j.bmcl.2023.129168  0.4
2022 Ghosh AK, Yuan H. Total Syntheses of the Proposed Structure of Iriomoteolide-1a, -1b and Synthesis of Three Derivatives for Structural Studies. Marine Drugs. 20. PMID 36286411 DOI: 10.3390/md20100587  0.408
2022 Ghosh AK, Weber IT, Mitsuya H. Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance. Chemical Communications (Cambridge, England). PMID 36200462 DOI: 10.1039/d2cc04541a  0.344
2022 Ghosh AK, Kovela S, Sharma A, Shahabi D, Ghosh AK, Hopkins DR, Yadav M, Johnson ME, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H. Design, Synthesis and X-ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-furofuran derivatives as P2 ligands. Chemmedchem. PMID 35170223 DOI: 10.1002/cmdc.202200058  0.842
2022 Amano M, Yedidi RS, Salcedo-Gómez PM, Hayashi H, Hasegawa K, Martyr CD, Ghosh AK, Mitsuya H. Fluorine-Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier (BBB) Penetration Property of Novel Central Nervous System (CNS)-targeting HIV-1 Protease Inhibitors . Antimicrobial Agents and Chemotherapy. AAC0171521. PMID 34978889 DOI: 10.1128/AAC.01715-21  0.342
2021 Ghosh AK, Shahabi D, Yadav M, Kovela S, Anson BJ, Lendy EK, Bonham C, Sirohi D, Brito-Sierra CA, Hattori SI, Kuhn R, Mitsuya H, Mesecar AD. Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors. Molecules (Basel, Switzerland). 26. PMID 34641337 DOI: 10.3390/molecules26195782  0.803
2021 Agniswamy J, Kneller DW, Ghosh AK, Weber IT. Novel HIV PR inhibitors with C4-substituted bis-THF and bis-fluoro-benzyl target the two active site mutations of highly drug resistant mutant PR. Biochemical and Biophysical Research Communications. 566: 30-35. PMID 34111669 DOI: 10.1016/j.bbrc.2021.05.094  0.334
2021 Ghosh AK, Yadav M. Highly Diastereoselective Intramolecular Asymmetric Oxidopyrylium-olefin [5 + 2] Cycloaddition and Synthesis of 8-Oxabicyclo[3.2.1]oct-3-enone Containing Ring Systems. The Journal of Organic Chemistry. PMID 34015224 DOI: 10.1021/acs.joc.1c00600  0.316
2021 Ghosh AK, Hsu CS. Enantioselective Total Synthesis of (+)-EBC-23, a Potent Anticancer Agent from the Australian Rainforest. The Journal of Organic Chemistry. PMID 33872504 DOI: 10.1021/acs.joc.1c00172  0.304
2021 Ghosh AK, Allu SR, Reddy GC, Lopez AG, Mendez P, Jurica MS. Design and synthesis of herboxidiene derivatives that potently inhibit splicing. Organic & Biomolecular Chemistry. PMID 33480941 DOI: 10.1039/d0ob02532a  0.327
2020 Ghosh AK, Markad SB, Robinson WL. The Chiron Approach to (3,3,6)-Hexahydrofuro[2,3-]furan-3-ol, a Key Subunit of HIV-1 Protease Inhibitor Drug, Darunavir. The Journal of Organic Chemistry. PMID 33267583 DOI: 10.1021/acs.joc.0c02396  0.409
2020 Ghosh AK, Grillo A, Raghavaiah J, Kovela S, Johnson ME, Kneller DW, Wang YF, Hattori SI, Higashi-Kuwata N, Weber IT, Mitsuya H. Design, Synthesis, and X-ray Studies of Potent HIV-1 Protease Inhibitors with P2-Carboxamide Functionalities. Acs Medicinal Chemistry Letters. 11: 1965-1972. PMID 33062180 DOI: 10.1021/Acsmedchemlett.9B00670  0.847
2020 Hattori SI, Higshi-Kuwata N, Raghavaiah J, Das D, Bulut H, Davis DA, Takamatsu Y, Matsuda K, Takamune N, Kishimoto N, Okamura T, Misumi S, Yarchoan R, Maeda K, Ghosh AK, et al. GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection. Mbio. 11. PMID 32820005 DOI: 10.1128/Mbio.01833-20  0.341
2020 Ghosh AK, Belcher MR. Lewis Acid-Catalyzed Vinyl Acetal Rearrangement of 4,5-Dihydro-1,3-dioxepines: Stereoselective Synthesis of and 2,3-Disubstituted Tetrahydrofurans. The Journal of Organic Chemistry. PMID 32806103 DOI: 10.1021/Acs.Joc.0C00390  0.81
2020 Bulut H, Hattori SI, Aoki-Ogata H, Hayashi H, Das D, Aoki M, Davis DA, Rao KV, Nyalapatla PR, Ghosh AK, Mitsuya H. Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity. Scientific Reports. 10: 10664. PMID 32606378 DOI: 10.1038/S41598-020-65993-Z  0.464
2020 Ghosh AK, Born JR, Veitschegger AM, Jurica MS. Copper-Catalyzed Stille Cross-Coupling Reaction and Application in the Synthesis of the Spliceostatin Core Structure. The Journal of Organic Chemistry. PMID 32515594 DOI: 10.1021/Acs.Joc.0C00976  0.405
2020 Ghosh AK, Kovela S, Osswald HL, Amano M, Aoki M, Agniswamy J, Wang YF, Weber IT, Mitsuya H. Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies. Journal of Medicinal Chemistry. PMID 32348139 DOI: 10.1021/Acs.Jmedchem.0C00202  0.84
2019 Aoki M, Chang SB, Das D, Martyr C, Delino NS, Takamatsu Y, Ghosh AK, Mitsuya H. A novel HIV-1 protease inhibitor, GRL-044, has potent activity against various HIV-1s with an extremely high genetic barrier to the emergence of HIV-1 drug resistance. Global Health & Medicine. 1: 36-48. PMID 33330753 DOI: 10.35772/ghm.2019.01003  0.338
2019 Ghosh AK, Grillo A, Kovela S, Brindisi M. Asymmetric Diels-Alder reaction of 3-(acyloxy) acryloyl oxazolidinones: optically active synthesis of a high-affinity ligand for potent HIV-1 protease inhibitors. Rsc Advances. 9: 41755-41763. PMID 32655859 DOI: 10.1039/C9Ra10178K  0.85
2019 Ghosh AK, Brindisi M. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. Journal of Medicinal Chemistry. PMID 31789518 DOI: 10.1021/Acs.Jmedchem.9B01541  0.318
2019 Yen YC, Kammeyer A, Jensen KC, Tirlangi J, Ghosh AK, Mesecar AD. Development of an efficient enzyme production and structure-based discovery platform for BACE1 inhibitors. Biochemistry. PMID 31549827 DOI: 10.1021/Acs.Biochem.9B00714  0.378
2019 Ghosh AK, Xia Z, Kovela S, Robinson WL, Johnson ME, Kneller DW, Wang YF, Aoki M, Takamatsu Y, Weber IT, Mitsuya H. Potent HIV-1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein-ligand X-ray Structural Studies. Chemmedchem. PMID 31549492 DOI: 10.1002/Cmdc.201900508  0.843
2019 Kneller DW, Agniswamy J, Ghosh AK, Weber IT. Potent antiviral HIV-1 protease inhibitor combats highly drug resistant mutant PR20. Biochemical and Biophysical Research Communications. PMID 31474336 DOI: 10.1016/J.Bbrc.2019.08.126  0.461
2019 Ghosh AK, Williams JN, Kovela S, Takayama J, Simpson HM, Walters DE, Hattori SI, Aoki M, Mitsuya H. Potent HIV-1 protease inhibitors incorporating squaramide-derived P2 ligands: Design, synthesis, and biological evaluation. Bioorganic & Medicinal Chemistry Letters. PMID 31416666 DOI: 10.1016/J.Bmcl.2019.08.006  0.839
2019 Ghosh AK, Robinson WL. A Photochemical Route to Optically Active Hexahydro-4-furopyranol, a High-Affinity P2 Ligand for HIV-1 Protease Inhibitors. The Journal of Organic Chemistry. PMID 31310117 DOI: 10.1021/Acs.Joc.9B01361  0.472
2019 Pawar S, Wang YF, Wong-Sam A, Agniswamy J, Ghosh AK, Harrison RW, Weber IT. Structural studies of antiviral inhibitor with HIV-1 protease bearing drug resistant substitutions of V32I, I47V and V82I. Biochemical and Biophysical Research Communications. PMID 31092330 DOI: 10.1016/J.Bbrc.2019.05.064  0.469
2019 Takamatsu Y, Aoki M, Bulut H, Das D, Amano M, Sheri VR, Kovari LC, Hayashi H, Delino NS, Ghosh AK, Mitsuya H. Novel protease inhibitors containing -5-modified -THF and aminobenzothiazole as P2 and P2' ligands that exert potent antiviral activity against highly multidrug-resistant HIV-1 with high genetic barrier against the emergence of drug resistance. Antimicrobial Agents and Chemotherapy. PMID 31085520 DOI: 10.1128/Aac.00372-19  0.452
2019 Amano M, Salcedo-Gómez PM, Yedidi RS, Zhao R, Hayashi H, Hasegawa K, Nakamura T, Martyr CD, Ghosh AK, Mitsuya H. Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications. Antimicrobial Agents and Chemotherapy. PMID 31061155 DOI: 10.1128/Aac.00466-19  0.434
2019 Ghosh AK, Lee DS. Enantioselective Total Synthesis of (+)-Monocerin, a Dihydroisocoumarin Derivative with Potent Antimalarial Properties. The Journal of Organic Chemistry. PMID 31033292 DOI: 10.1021/Acs.Joc.9B00414  0.458
2019 Hattori SI, Hayashi H, Bulut H, Rao KV, Nyalapatla PR, Hasegawa K, Aoki M, Ghosh AK, Mitsuya H. Halogen bond interactions of novel HIV-1 protease inhibitors (PI)(GRL-001-15 and GRL-003-15) with the flap of protease are critical for their potent activity against wild-type and multi-PI-resistant HIV-1 variants. Antimicrobial Agents and Chemotherapy. PMID 30962341 DOI: 10.1128/Aac.02635-18  0.447
2019 Ghosh AK, Born JR, Kassekert LA. Enantioselective Total Syntheses of (+)-Fendleridine and (+)-Acetylaspidoalbidine. The Journal of Organic Chemistry. PMID 30939004 DOI: 10.1021/Acs.Joc.9B00145  0.418
2019 Nakata H, Maeda K, Das D, Chang SB, Matsuda K, Rao KV, Harada S, Yoshimura K, Ghosh AK, Mitsuya H. Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s. Scientific Reports. 9: 4828. PMID 30886166 DOI: 10.1038/S41598-019-41080-W  0.476
2019 Ghosh AK, Brindisi M, Yen YC, Lendy EK, Kovela S, Cárdenas EL, Reddy BS, Rao KV, Downs D, Huang X, Tang J, Mesecar AD. Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies. Chemmedchem. PMID 30637955 DOI: 10.1002/Cmdc.201800725  0.809
2019 Ghosh AK, Hussain KA, Fidanze S. Asymmetric Aldol Route to Hydroxyethylamine Isostere: Stereoselective Synthesis of the Core Unit of Saquinavir. The Journal of Organic Chemistry. 62: 6080-6082. PMID 30504991 DOI: 10.1021/Jo9706943  0.381
2019 Ghosh AK, Li J, Perali RS. A Stereoselective Anti-Aldol Route to (3,3a,6a)-Hexahydrofuro[2,3-] furan-3-ol: A Key Ligand for a New Generation of HIV Protease Inhibitors. Synthesis. 2006: 3015-3018. PMID 30443083 DOI: 10.1055/S-2006-942547  0.431
2019 He M, Ghosh AK, Zajc B. Julia Olefination as a General Route to Phenyl (alpha-Fluoro)vinyl Sulfones. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 2008: 999-1004. PMID 19888442 DOI: 10.1055/S-2008-1072513  0.351
2019 Ghosh AK, Takayama J. Enantioselective Synthesis of Cyclopentyltetrahydrofuran (Cp-THF), an Important High-Affinity P2-Ligand for HIV-1 Protease Inhibitors. Tetrahedron Letters. 49: 3409-3412. PMID 18548130 DOI: 10.1016/J.Tetlet.2008.03.116  0.528
2019 Ghosh AK, Wang Y. Total Synthesis of (+)-Polyoxin J. The Journal of Organic Chemistry. 64: 2789-2795. PMID 11674347 DOI: 10.1021/Jo9822378  0.401
2019 Ghosh AK, Fidanze S. Transition-State Mimetics for HIV Protease Inhibitors: Stereocontrolled Synthesis of Hydroxyethylene and Hydroxyethylamine Isosteres by Ester-Derived Titanium Enolate Syn and Anti-Aldol Reactions. The Journal of Organic Chemistry. 63: 6146-6152. PMID 11672244 DOI: 10.1021/Jo980159I  0.501
2019 Ghosh AK, Liu W. A Convergent, Enantioselective Total Synthesis of Streptogramin Antibiotic (-)-Madumycin II. The Journal of Organic Chemistry. 62: 7908-7909. PMID 11671887 DOI: 10.1021/Jo971616I  0.318
2019 Ghosh AK, Liu W. Total Synthesis of (+)-Sinefungin. The Journal of Organic Chemistry. 62: 2299. PMID 11671549 DOI: 10.1021/Jo964030P  0.366
2019 Ghosh AK, Grillo A, Kovela S, Brindisi M. Asymmetric Diels–Alder reaction of 3-(acyloxy)acryloyl oxazolidinones: optically active synthesis of a high-affinity ligand for potent HIV-1 protease inhibitors Rsc Advances. 9: 41755-41763. DOI: 10.1039/c9ra10178k  0.421
2019 Ghosh AK, Brindisi M, Yen Y, Lendy EK, Kovela S, Cárdenas EL, Reddy BS, Rao KV, Downs D, Huang X, Tang J, Mesecar AD. Cover Feature: Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies (ChemMedChem 5/2019) Chemmedchem. 14: 513-513. DOI: 10.1002/Cmdc.201900100  0.361
2018 Ghosh AK, Brindisi M. Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors. Asian Journal of Organic Chemistry. 7: 1448-1466. PMID 31595212 DOI: 10.1002/Ajoc.201800255  0.494
2018 Ghosh AK, Reddy GC, Kovela S, Relitti N, Urabe VK, Prichard BE, Jurica MS. Enantioselective Synthesis of a Cyclopropane Derivative of Spliceostatin A and Evaluation of Bioactivity. Organic Letters. PMID 30394756 DOI: 10.1021/Acs.Orglett.8B03228  0.822
2018 Ghosh AK, Williams JN, Ho RY, Simpson HM, Hattori SI, Hayashi H, Agniswamy J, Wang YF, Weber IT, Mitsuya H. Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure-Activity Studies and Biological and X-ray Structural Studies. Journal of Medicinal Chemistry. PMID 30354121 DOI: 10.2210/Pdb6E7J/Pdb  0.529
2018 Ghosh AK, Jadhav RD, Simpson H, Kovela S, Osswald H, Agniswamy J, Wang YF, Hattori SI, Weber IT, Mitsuya H. Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands. European Journal of Medicinal Chemistry. 160: 171-182. PMID 30340140 DOI: 10.2210/Pdb6Dv4/Pdb  0.835
2018 Wong-Sam A, Wang YF, Zhang Y, Ghosh AK, Harrison RW, Weber IT. Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease. Acs Omega. 3: 12132-12140. PMID 30288468 DOI: 10.1021/acsomega.8b01683  0.303
2018 Ghosh AK, Brindisi M, Sarkar A. The Curtius Rearrangement: Applications in Modern Drug Discovery and Medicinal Chemistry. Chemmedchem. PMID 30187672 DOI: 10.1002/Cmdc.201800518  0.338
2018 Ghosh AK, Simpson HM, Veitschegger AM. Enantioselective total synthesis of decytospolide A and decytospolide B using an Achmatowicz reaction. Organic & Biomolecular Chemistry. PMID 30083684 DOI: 10.1039/C8Ob01529E  0.401
2018 Ghosh AK, Ghosh K, Brindisi M, Lendy EK, Yen YC, Kumaragurubaran N, Huang X, Tang J, Mesecar AD. Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand. Bioorganic & Medicinal Chemistry Letters. PMID 29970308 DOI: 10.1016/J.Bmcl.2018.06.045  0.786
2018 Ghosh AK, R Nyalapatla P, Kovela S, Rao KV, Brindisi M, Osswald HL, Amano M, Aoki M, Agniswamy J, Wang YF, Weber IT, Mitsuya H. Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis. Journal of Medicinal Chemistry. PMID 29763303 DOI: 10.1021/Acs.Jmedchem.8B00298  0.846
2018 Ren J, Mistry TL, Su PC, Mehboob S, Demissie R, Fung LW, Ghosh AK, Johnson ME. Determination of absolute configuration and binding efficacy of benzimidazole-based FabI inhibitors through the support of electronic circular dichroism and MM-GBSA techniques. Bioorganic & Medicinal Chemistry Letters. PMID 29730028 DOI: 10.1016/J.Bmcl.2018.04.052  0.319
2018 Ghosh AK, Veitschegger AM, Nie S, Relitti N, MacRae AJ, Jurica MS. Enantioselective Synthesis of Thailanstatin A Methyl Ester and Evaluation of in Vitro Splicing Inhibition. The Journal of Organic Chemistry. PMID 29696980 DOI: 10.1021/Acs.Joc.8B00593  0.448
2018 Aoki M, Das D, Hayashi H, Aoki-Ogata H, Takamatsu Y, Ghosh AK, Mitsuya H. Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance. Mbio. 9. PMID 29511083 DOI: 10.1128/Mbio.02425-17  0.426
2018 Ghosh AK, Sarkar A, Brindisi M. The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses. Organic & Biomolecular Chemistry. PMID 29479624 DOI: 10.1039/C8Ob00138C  0.41
2018 Delino NS, Aoki M, Hayashi H, Hattori SI, Chang SB, Takamatsu Y, Martyr CD, Das D, Ghosh AK, Mitsuya H. GRL-079, a novel P2-Tp-THF-C5-alkylamine- and P2' -Abt-containing HIV-1 protease inhibitor, is extremely potent against multi-drug-resistant HIV-1 variants including HIVand has a high genetic barrier against the emergence of resistant variants. Antimicrobial Agents and Chemotherapy. PMID 29463535 DOI: 10.1128/Aac.02060-17  0.435
2018 Ghosh AK, Rao KV, Nyalapatla PR, Kovela S, Brindisi M, Osswald HL, Sekhara Reddy B, Agniswamy J, Wang YF, Aoki M, Hattori SI, Weber IT, Mitsuya H. Design of Highly Potent, Dual Acting and Central Nervous System Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants. Chemmedchem. PMID 29437300 DOI: 10.1002/Cmdc.201700824  0.835
2018 Bulut H, Aoki M, Hayashi H, Aoki-Ogata H, Hattori S, Ghosh AK, Mitsuya H. Novel protease inhibitors markedly adapting to the structural plasticity of HIV-1 protease exert extreme potency with high genetic barrier Acta Crystallographica Section a Foundations and Advances. 74: a169-a169. DOI: 10.1107/S0108767318098306  0.423
2018 Ghosh AK, Rao KV, Nyalapatla PR, Kovela S, Brindisi M, Osswald HL, Sekhara Reddy B, Agniswamy J, Wang Y, Aoki M, Hattori S, Weber IT, Mitsuya H. Front Cover: Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants (ChemMedChem 8/2018) Chemmedchem. 13: 762-762. DOI: 10.1002/Cmdc.201800226  0.786
2017 Ghosh AK, Tomaine AJ, Cantwell KE. Lewis Acid Mediated Cyclizations: Diastereoselective Synthesis of Six- to Eight-Membered Substituted Cyclic Ethers. Synthesis. 49: 4229-4246. PMID 29983455 DOI: 10.1055/S-0036-1589054  0.426
2017 Ghosh AK, Cárdenas EL, Brindisi M. Highly Stereoselective Asymmetric Aldol Routes to tert-Butyl-2-(3,5-difluorophenyl)-1-oxiran-2-yl)ethyl)carbamates: Building Blocks for Novel Protease Inhibitors. Tetrahedron Letters. 58: 4062-4065. PMID 29335658 DOI: 10.1016/J.Tetlet.2017.09.025  0.437
2017 Ghosh AK, Sarkar A. An enantioselective enzymatic desymmetrization route to hexahydro-4H-furopyranol, a high-affinity ligand for HIV-1 protease inhibitors. Tetrahedron Letters. 58: 3230-3233. PMID 29200514 DOI: 10.1016/J.Tetlet.2017.07.010  0.51
2017 Ghosh AK, Fyvie WS, Brindisi M, Steffey M, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H. Design, synthesis, biological evaluation, and X-ray studies of HIV-1 protease inhibitors with modified P2'-ligands of Darunavir. Chemmedchem. PMID 29110408 DOI: 10.1002/Cmdc.201700614  0.528
2017 Aoki M, Hayashi H, Rao KV, Das D, Higashi-Kuwata N, Bulut H, Aoki-Ogata H, Takamatsu Y, Yedidi RS, Davis DA, Hattori SI, Nishida N, Hasegawa K, Takamune N, Nyalapatla PR, ... ... Ghosh AK, et al. A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency. Elife. 6. PMID 29039736 DOI: 10.7554/Elife.28020  0.783
2017 Ghosh AK, Nyalapatla PR. Total syntheses of both enantiomers of amphirionin 4: A chemoenzymatic based strategy for functionalized tetrahydrofurans. Tetrahedron. 73: 1820-1830. PMID 28970641 DOI: 10.1016/J.Tet.2017.02.031  0.356
2017 Ghosh AK, Sean Fyvie W, Brindisi M, Steffey M, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H. Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands. Bioorganic & Medicinal Chemistry Letters. PMID 28958624 DOI: 10.1016/J.Bmcl.2017.09.003  0.503
2017 Amano M, Miguel Salcedo-Gómez P, Yedidi RS, Delino NS, Nakata H, Venkateswara Rao K, Ghosh AK, Mitsuya H. GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro. Scientific Reports. 7: 12235. PMID 28947797 DOI: 10.1038/S41598-017-12052-9  0.455
2017 Ghosh AK, Brindisi M, Nyalapatla PR, Takayama J, Ella-Menye JR, Yashchuk S, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H. Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex. Bioorganic & Medicinal Chemistry. PMID 28434781 DOI: 10.1016/J.Bmc.2017.04.005  0.827
2017 Ghosh AK, Brindisi M, Yen YC, Cárdenas EL, Ella-Menye JR, Kumaragurubaran N, Huang X, Tang J, Mesecar AD. Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands. Bioorganic & Medicinal Chemistry Letters. PMID 28427814 DOI: 10.1016/J.Bmcl.2017.04.011  0.454
2017 Ghosh AK, Rao KV, Nyalapatla PR, Osswald HL, Martyr CD, Aoki M, Hayashi H, Agniswamy J, Wang YF, Bulut H, Das D, Weber IT, Mitsuya H. Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants. Journal of Medicinal Chemistry. PMID 28418652 DOI: 10.1021/Acs.Jmedchem.7B00172  0.82
2017 Benko Z, Liang D, Li G, Elder RT, Sarkar A, Takayama J, Ghosh AK, Zhao RY. A fission yeast cell-based system for multidrug resistant HIV-1 proteases. Cell & Bioscience. 7: 5. PMID 28096973 DOI: 10.1186/S13578-016-0131-5  0.413
2016 Ghosh AK, Brindisi M. Achmatowicz Reaction and its Application in the Syntheses of Bioactive Molecules. Rsc Advances. 6: 111564-111598. PMID 28944049 DOI: 10.1039/C6Ra22611F  0.402
2016 Ghosh AK, Sarkar A. Enantioselective Syntheses of (-)-Alloyohimbane and (-)-Yohimbane by an Efficient Enzymatic Desymmetrization Process. European Journal of Organic Chemistry. 2016: 6001-6009. PMID 28757804 DOI: 10.1002/Ejoc.201601171  0.412
2016 Ghosh AK, Rodriguez S. An enantioselective synthesis of the C3-C21 segment of the macrolide immunosuppressive agent FR252921. Tetrahedron Letters. 57: 2884-2887. PMID 27818534 DOI: 10.1016/J.Tetlet.2016.05.067  0.335
2016 Ghosh AK, Kassekert LA, Bungard JD. Enantioselective total synthesis and structural assignment of callyspongiolide. Organic & Biomolecular Chemistry. PMID 27762414 DOI: 10.1039/C6Ob02051H  0.398
2016 Mistry TL, Truong L, Ghosh AK, Johnson ME, Mehboob S. Benzimidazole-based FabI inhibitors: A promising novel scaffold for anti-staphylococcal drug development. Acs Infectious Diseases. PMID 27756129 DOI: 10.1021/Acsinfecdis.6B00123  0.357
2016 Amano M, Salcedo-Gómez PM, Zhao R, Yedidi RS, Das D, Bulut H, Delino NS, Reddy SV, Ghosh AK, Mitsuya H. A Modified P1 Moiety Enhances in vitro Antiviral Activity against Various Multi-Drug-Resistant HIV-1 Variants and in vitro CNS Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413. Antimicrobial Agents and Chemotherapy. PMID 27620483 DOI: 10.1128/Aac.01428-16  0.456
2016 Ghosh AK, Osswald HL, Glauninger K, Agniswamy J, Wang YF, Hayashi H, Aoki M, Weber IT, Mitsuya H. Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation. Journal of Medicinal Chemistry. PMID 27389367 DOI: 10.1021/Acs.Jmedchem.6B00639  0.806
2016 Ghosh AK, Reddy BS, Yen YC, Cardenas E, Rao KV, Downs D, Huang X, Tang J, Mesecar AD. Design of Potent and Highly Selective Inhibitors for Human β-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes. Chemical Science (Royal Society of Chemistry : 2010). 7: 3117-3122. PMID 27347366 DOI: 10.1039/C5Sc03718B  0.324
2016 Ghosh AK, Nyalapatla PR. Correction to Enantioselective Total Synthesis of (+)-Amphirionin-4. Organic Letters. PMID 27333151 DOI: 10.1021/Acs.Orglett.6B01620  0.386
2016 Ghosh AK, Kassekert LA. Enantioselective Synthesis of Both Epimers at C-21 in the Proposed Structure of Cytotoxic Macrolide Callyspongiolide. Organic Letters. PMID 27331421 DOI: 10.1021/Acs.Orglett.6B01523  0.365
2016 Ghosh AK, Lv K, Ma N, Cárdenas EL, Effenberger KA, Jurica MS. Design, synthesis and in vitro splicing inhibition of desmethyl and carba-derivatives of herboxidiene. Organic & Biomolecular Chemistry. PMID 27188838 DOI: 10.1039/C6Ob00725B  0.474
2016 Ghosh AK, Nyalapatla PR. Enantioselective Total Synthesis of (+)-Amphirionin-4. Organic Letters. PMID 27116318 DOI: 10.1021/Acs.Orglett.6B00942  0.44
2016 Ghosh AK, Tomaine AJ, Cantwell KE. Stereoselective Synthesis of Substituted Oxocene Cores by Lewis Acid Promoted Cyclization. Organic Letters. PMID 26829580 DOI: 10.1021/Acs.Orglett.5B03411  0.431
2016 Ghosh AK, Osswald HL, Prato G. Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS. Journal of Medicinal Chemistry. PMID 26799988 DOI: 10.1021/Acs.Jmedchem.5B01697  0.778
2016 Effenberger KA, Urabe VK, Prichard BE, Ghosh AK, Jurica MS. Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages. Rna (New York, N.Y.). PMID 26742993 DOI: 10.1261/Rna.053108.115  0.374
2015 St John SE, Therkelsen MD, Nyalapatla PR, Osswald HL, Ghosh AK, Mesecar AD. X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design. Bioorganic & Medicinal Chemistry Letters. 25: 5072-7. PMID 26592814 DOI: 10.1016/J.Bmcl.2015.10.023  0.76
2015 Aoki M, Hayashi H, Yedidi RS, Martyr CD, Takamatsu Y, Aoki-Ogata H, Nakamura T, Nakata H, Das D, Yamagata Y, Ghosh AK, Mitsuya H. The C5-substituted Tetrahydropyrano-tetrahydofuran-derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs Including Darunavir. Journal of Virology. PMID 26581995 DOI: 10.1128/Jvi.01829-15  0.447
2015 Ghosh AK, Martyr CD, Kassekert LA, Nyalapatla PR, Steffey M, Agniswamy J, Wang YF, Weber IT, Amano M, Mitsuya H. Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands. Organic & Biomolecular Chemistry. PMID 26462551 DOI: 10.1039/C5Ob01930C  0.507
2015 Ghosh AK, Martyr CD, Osswald HL, Sheri VR, Kassekert LA, Chen S, Agniswamy J, Wang YF, Hayashi H, Aoki M, Weber IT, Mitsuya H. Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies. Journal of Medicinal Chemistry. PMID 26306007 DOI: 10.1021/Acs.Jmedchem.5B00900  0.812
2015 Ghosh AK, Xu CX, Osswald HL. Enantioselective Synthesis of Dioxatriquinane Structural Motifs for HIV-1 Protease Inhibitors Using a Cascade Radical Cyclization. Tetrahedron Letters. 56: 3314-3317. PMID 26185337 DOI: 10.1016/J.Tetlet.2015.01.019  0.817
2015 Ghosh AK, Yu X, Osswald HL, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H. Structure-Based Design of Potent HIV-1 Protease Inhibitors with Modified P1-Biphenyl Ligands: Synthesis, Biological Evaluation, and Enzyme-Inhibitor X-ray Structural Studies. Journal of Medicinal Chemistry. PMID 26107245 DOI: 10.1021/Acs.Jmedchem.5B00676  0.822
2015 Ghosh AK, Takayama J, Kassekert LA, Ella-Menye JR, Yashchuk S, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H. Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands. Bioorganic & Medicinal Chemistry Letters. PMID 26096678 DOI: 10.1016/J.Bmcl.2015.05.052  0.838
2015 Tomar S, Johnston ML, St John SE, Osswald HL, Nyalapatla PR, Paul LN, Ghosh AK, Denison MR, Mesecar AD. Ligand-induced dimerization of MERS coronavirus nsp5 protease (3CLpro): implications for nsp5 regulation and the development of antivirals. The Journal of Biological Chemistry. PMID 26055715 DOI: 10.1074/Jbc.M115.651463  0.763
2015 Agniswamy J, Louis JM, Shen CH, Yashchuk S, Ghosh AK, Weber IT. Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20. Journal of Medicinal Chemistry. 58: 5088-95. PMID 26010498 DOI: 10.1021/Acs.Jmedchem.5B00474  0.803
2015 Lee H, Lei H, Santarsiero BD, Gatuz JL, Cao S, Rice AJ, Patel K, Szypulinski MZ, Ojeda I, Ghosh AK, Johnson ME. Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV. Acs Chemical Biology. 10: 1456-65. PMID 25746232 DOI: 10.1021/Cb500917M  0.37
2015 Amano M, Tojo Y, Salcedo-Gómez PM, Parham GL, Nyalapatla PR, Das D, Ghosh AK, Mitsuya H. A novel tricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor, GRL-0739, effectively inhibits the replication of multidrug-resistant HIV-1 variants and has a desirable central nervous system penetration property in vitro. Antimicrobial Agents and Chemotherapy. 59: 2625-35. PMID 25691652 DOI: 10.1128/Aac.04757-14  0.454
2015 Mehboob S, Song J, Hevener KE, Su PC, Boci T, Brubaker L, Truong L, Mistry T, Deng J, Cook JL, Santarsiero BD, Ghosh AK, Johnson ME. Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI). Bioorganic & Medicinal Chemistry Letters. 25: 1292-6. PMID 25677657 DOI: 10.1016/J.Bmcl.2015.01.048  0.37
2015 Das D, Maeda K, Hayashi Y, Gavande N, Desai DV, Chang SB, Ghosh AK, Mitsuya H. Insights into the mechanism of inhibition of CXCR4: identification of Piperidinylethanamine analogs as anti-HIV-1 inhibitors. Antimicrobial Agents and Chemotherapy. 59: 1895-904. PMID 25583709 DOI: 10.1128/Aac.04654-14  0.467
2015 Ghosh AK, Brindisi M, Yen YC, Xu X, Huang X, Devasamudram T, Bilcer G, Lei H, Koelsch G, Mesecar AD, Tang J. Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand. Bioorganic & Medicinal Chemistry Letters. 25: 668-72. PMID 25537272 DOI: 10.1016/J.Bmcl.2014.11.087  0.57
2015 Ghosh AK, Yashchuk S, Mizuno A, Chakraborty N, Agniswamy J, Wang YF, Aoki M, Gomez PM, Amano M, Weber IT, Mitsuya H. Design of gem-difluoro-bis-tetrahydrofuran as P2 ligand for HIV-1 protease inhibitors to improve brain penetration: synthesis, X-ray studies, and biological evaluation. Chemmedchem. 10: 107-15. PMID 25336073 DOI: 10.1002/Cmdc.201402358  0.831
2015 Hatial I, Das J, Ghosh AK, Basak A. Base-Induced Cyclization of Propargyl Alkenylsulfones: A High-Yielding Synthesis of 4,5-Disubstituted 2H-Thiopyran 1,1-Dioxides European Journal of Organic Chemistry. 2015: 6017-6024. DOI: 10.1002/Ejoc.201500633  0.553
2014 Ghosh AK, Lv K. A convergent synthesis of carbocyclic sinefungin and its C5 epimer. European Journal of Organic Chemistry. 2014: 6761-6768. PMID 25530707 DOI: 10.1002/Ejoc.201402812  0.408
2014 Ghosh AK, Veitschegger AM, Sheri VR, Effenberger KA, Prichard BE, Jurica MS. Enantioselective synthesis of spliceostatin E and evaluation of biological activity. Organic Letters. 16: 6200-3. PMID 25423085 DOI: 10.1021/Ol503127R  0.376
2014 Ghosh AK, Rao KV, Akasapu S. An Enantioselective Synthesis of a MEM-Protected Aetheramide A Derivative. Tetrahedron Letters. 55: 5191-5194. PMID 25197148 DOI: 10.1016/J.Tetlet.2014.07.077  0.497
2014 Ghosh AK, Keyes C, Veitschegger AM. FeCl3-Catalyzed Tandem Prins and Friedel-Crafts Cyclization: A Highly Diastereoselective Route to Polycyclic Ring Structures. Tetrahedron Letters. 55: 4251-4254. PMID 25104867 DOI: 10.1016/J.Tetlet.2014.05.092  0.817
2014 Deng X, StJohn SE, Osswald HL, O'Brien A, Banach BS, Sleeman K, Ghosh AK, Mesecar AD, Baker SC. Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance. Journal of Virology. 88: 11886-98. PMID 25100843 DOI: 10.1128/Jvi.01528-14  0.746
2014 Hayashi H, Takamune N, Nirasawa T, Aoki M, Morishita Y, Das D, Koh Y, Ghosh AK, Misumi S, Mitsuya H. Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir. Proceedings of the National Academy of Sciences of the United States of America. 111: 12234-9. PMID 25092296 DOI: 10.1073/Pnas.1400027111  0.422
2014 Ghosh AK, Schiltz GE, Rusere LN, Osswald HL, Walters DE, Amano M, Mitsuya H. Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands. Organic & Biomolecular Chemistry. 12: 6842-54. PMID 25050776 DOI: 10.1039/C4Ob00738G  0.811
2014 Ghosh AK, Chen ZH, Effenberger KA, Jurica MS. Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives. The Journal of Organic Chemistry. 79: 5697-709. PMID 24873648 DOI: 10.1021/Jo500800K  0.444
2014 Ghosh AK, Ma N, Effenberger KA, Jurica MS. Total synthesis of GEX1Q1, assignment of C-5 stereoconfiguration and evaluation of spliceosome inhibitory activity. Organic Letters. 16: 3154-7. PMID 24869489 DOI: 10.1021/Ol501345D  0.418
2014 Mandal SM, Roy A, Ghosh AK, Hazra TK, Basak A, Franco OL. Challenges and future prospects of antibiotic therapy: from peptides to phages utilization. Frontiers in Pharmacology. 5: 105. PMID 24860506 DOI: 10.3389/Fphar.2014.00105  0.445
2014 Ghosh AK, Chen ZH. An intramolecular cascade cyclization of 2-aryl indoles: efficient methods for the construction of 2,3-functionalized indolines and 3-indolinones. Organic & Biomolecular Chemistry. 12: 3567-71. PMID 24788461 DOI: 10.1039/C4Ob00511B  0.355
2014 Yedidi RS, Garimella H, Aoki M, Aoki-Ogata H, Desai DV, Chang SB, Davis DA, Fyvie WS, Kaufman JD, Smith DW, Das D, Wingfield PT, Maeda K, Ghosh AK, Mitsuya H. A conserved hydrogen-bonding network of P2 bis-tetrahydrofuran-containing HIV-1 protease inhibitors (PIs) with a protease active-site amino acid backbone aids in their activity against PI-resistant HIV. Antimicrobial Agents and Chemotherapy. 58: 3679-88. PMID 24752271 DOI: 10.1128/Aac.00107-14  0.432
2014 Ghosh AK, Osswald HL. BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease. Chemical Society Reviews. 43: 6765-813. PMID 24691405 DOI: 10.1039/C3Cs60460H  0.745
2014 Agnihothram S, Yount BL, Donaldson EF, Huynh J, Menachery VD, Gralinski LE, Graham RL, Becker MM, Tomar S, Scobey TD, Osswald HL, Whitmore A, Gopal R, Ghosh AK, Mesecar A, et al. A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant. Mbio. 5: e00047-14. PMID 24667706 DOI: 10.1128/Mbio.00047-14  0.718
2014 Effenberger KA, Anderson DD, Bray WM, Prichard BE, Ma N, Adams MS, Ghosh AK, Jurica MS. Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs. The Journal of Biological Chemistry. 289: 1938-47. PMID 24302718 DOI: 10.1074/Jbc.M113.515536  0.412
2014 Hatial I, Jana S, Bisai S, Das M, Ghosh AK, Anoop A, Basak A. Trienediynes on a 1,3,5-trisubstituted benzene template: A new approach for enhancement of reactivity Rsc Advances. 4: 28041-28045. DOI: 10.1039/C4Ra04794J  0.517
2014 Ghosh AK, Xu CX, Osswald HL. Enantioselective synthesis of dioxatriquinane structural motifs for HIV-1 protease inhibitors using a cascade radical cyclization Tetrahedron Letters. DOI: 10.1016/j.tetlet.2015.01.019  0.8
2014 Ghosh AK, Chen Z. ChemInform Abstract: Enantioselective Syntheses of FR901464 (Ib) and Spliceostatin A (Ia): Potent Inhibitors of Spliceosome. Cheminform. 45: no-no. DOI: 10.1002/chin.201410221  0.337
2014 Ghosh AK, Xi K. Platensimycin and Platencin Natural Products in Medicinal Chemistry. 271-300. DOI: 10.1002/9783527676545.ch08  0.454
2013 Ghosh AK, Zhou B. Enantioselective Synthesis of Spiro[cyclohexane-1,3'-indolin]-2'-ones Containing Multiple Stereocenters via Organocatalytic Michael/Aldol Cascade Reactions. Tetrahedron Letters. 54: 2311-2314. PMID 25705059 DOI: 10.1016/J.Tetlet.2013.02.030  0.379
2013 Chen H, Zhou B, Brecher M, Banavali N, Jones SA, Li Z, Zhang J, Nag D, Kramer LD, Ghosh AK, Li H. S-adenosyl-homocysteine is a weakly bound inhibitor for a flaviviral methyltransferase. Plos One. 8: e76900. PMID 24130807 DOI: 10.1371/Journal.Pone.0076900  0.352
2013 Ghosh AK, Shurrush KA, Dawson ZL. Enantioselective total synthesis of macrolide (+)-neopeltolide. Organic & Biomolecular Chemistry. 11: 7768-77. PMID 24121457 DOI: 10.1039/C3Ob41541D  0.807
2013 Salcedo Gómez PM, Amano M, Yashchuk S, Mizuno A, Das D, Ghosh AK, Mitsuya H. GRL-04810 and GRL-05010, difluoride-containing nonpeptidic HIV-1 protease inhibitors (PIs) that inhibit the replication of multi-PI-resistant HIV-1 in vitro and possess favorable lipophilicity that may allow blood-brain barrier penetration. Antimicrobial Agents and Chemotherapy. 57: 6110-21. PMID 24080647 DOI: 10.1128/Aac.01420-13  0.816
2013 Ghosh AK, Chen ZH. Enantioselective syntheses of FR901464 and spliceostatin A: potent inhibitors of spliceosome. Organic Letters. 15: 5088-91. PMID 24050251 DOI: 10.1021/Ol4024634  0.45
2013 Ghosh AK, Zhou B. Bifunctional cinchona alkaloid-squaramide-catalyzed highly enantioselective aza-Michael addition of indolines to α,β-unsaturated ketones. Tetrahedron Letters. 54: 3500-3502. PMID 24014895 DOI: 10.1016/J.Tetlet.2013.04.080  0.337
2013 Ghosh AK, Parham GL, Martyr CD, Nyalapatla PR, Osswald HL, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H. Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies. Journal of Medicinal Chemistry. 56: 6792-802. PMID 23947685 DOI: 10.1021/Jm400768F  0.81
2013 Butini S, Brogi S, Novellino E, Campiani G, Ghosh AK, Brindisi M, Gemma S. The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors. Current Topics in Medicinal Chemistry. 13: 1787-807. PMID 23931442 DOI: 10.2174/15680266113139990137  0.326
2013 Yedidi RS, Maeda K, Fyvie WS, Steffey M, Davis DA, Palmer I, Aoki M, Kaufman JD, Stahl SJ, Garimella H, Das D, Wingfield PT, Ghosh AK, Mitsuya H. P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel nonpeptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety. Antimicrobial Agents and Chemotherapy. 57: 4920-7. PMID 23877703 DOI: 10.1128/Aac.00868-13  0.467
2013 Lee H, Cao S, Hevener KE, Truong L, Gatuz JL, Patel K, Ghosh AK, Johnson ME. Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: mechanistic and inhibitor design implications. Chemmedchem. 8: 1361-72. PMID 23788528 DOI: 10.1002/Cmdc.201300134  0.365
2013 Weber IT, Waltman MJ, Mustyakimov M, Blakeley MP, Keen DA, Ghosh AK, Langan P, Kovalevsky AY. Joint X-ray/neutron crystallographic study of HIV-1 protease with clinical inhibitor amprenavir: insights for drug design. Journal of Medicinal Chemistry. 56: 5631-5. PMID 23772563 DOI: 10.1021/Jm400684F  0.399
2013 Agniswamy J, Shen CH, Wang YF, Ghosh AK, Rao KV, Xu CX, Sayer JM, Louis JM, Weber IT. Extreme multidrug resistant HIV-1 protease with 20 mutations is resistant to novel protease inhibitors with P1'-pyrrolidinone or P2-tris-tetrahydrofuran. Journal of Medicinal Chemistry. 56: 4017-27. PMID 23590295 DOI: 10.1021/Jm400231V  0.414
2013 Wu H, Downs D, Ghosh K, Ghosh AK, Staib P, Monod M, Tang J. Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2132-44. PMID 23430844 DOI: 10.1096/Fj.12-214353  0.742
2013 Amano M, Tojo Y, Salcedo-Gómez PM, Campbell JR, Das D, Aoki M, Xu CX, Rao KV, Ghosh AK, Mitsuya H. GRL-0519, a novel oxatricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor (PI), potently suppresses replication of a wide spectrum of multi-PI-resistant HIV-1 variants in vitro. Antimicrobial Agents and Chemotherapy. 57: 2036-46. PMID 23403426 DOI: 10.1128/Aac.02189-12  0.448
2013 Zhang H, Wang YF, Shen CH, Agniswamy J, Rao KV, Xu CX, Ghosh AK, Harrison RW, Weber IT. Novel P2 tris-tetrahydrofuran group in antiviral compound 1 (GRL-0519) fills the S2 binding pocket of selected mutants of HIV-1 protease. Journal of Medicinal Chemistry. 56: 1074-83. PMID 23298236 DOI: 10.1021/Jm301519Z  0.438
2013 Chen H, Liu L, Jones SA, Banavali N, Kass J, Li Z, Zhang J, Kramer LD, Ghosh AK, Li H. Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs. Antiviral Research. 97: 232-9. PMID 23267828 DOI: 10.1016/J.Antiviral.2012.12.012  0.732
2013 Ghosh AK, Chapsal BD. Design of the anti-HIV protease inhibitor darunavir Introduction to Biological and Small Molecule Drug Research and Development. 355-384. DOI: 10.1016/B978-0-12-397176-0.00013-3  0.311
2012 Ghosh AK, Kass J, Nicponski DR, Keyes C. Diastereoselective Synthesis of Substituted Tetrahydropyrans by Copper(II)-Bisphosphine-Catalyzed Olefin Migration and Prins Cyclization. Synthesis. 44: 3579-3589. PMID 30449905 DOI: 10.1055/S-0032-1317495  0.798
2012 Ghosh AK, Cheng X, Bai R, Hamel E. Total Synthesis of Potent Antitumor Macrolide, (-)-Zampanolide: An Oxidative Intramolecular Cyclization-Based Strategy. European Journal of Organic Chemistry. 2012: 4130-4139. PMID 23606808 DOI: 10.1002/Ejoc.201200286  0.447
2012 Ghosh AK, Cheng X, Zhou B. Enantioselective total synthesis of (+)-lithospermic acid. Organic Letters. 14: 5046-9. PMID 22978790 DOI: 10.1021/Ol302273R  0.487
2012 Ghosh AK, Venkateswara Rao K, Yadav ND, Anderson DD, Gavande N, Huang X, Terzyan S, Tang J. Structure-based design of highly selective β-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure. Journal of Medicinal Chemistry. 55: 9195-207. PMID 22954357 DOI: 10.1021/Jm3008823  0.415
2012 Ghosh AK, Anderson DD. Enantioselective total synthesis of pladienolide B: a potent spliceosome inhibitor. Organic Letters. 14: 4730-3. PMID 22954141 DOI: 10.1021/Ol301886G  0.431
2012 Ghosh AK, Pandey S, Gangarajula S, Kulkarni S, Xu X, Rao KV, Huang X, Tang J. Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 5460-5. PMID 22863204 DOI: 10.1016/J.Bmcl.2012.07.043  0.706
2012 Ghosh AK, Cheng X. Synthesis of Functionalized 4-Methylenetetrahydropyrans by Oxidative Activation of Cinnamyl or Benzyl Ethers. Tetrahedron Letters. 53: 2568-2570. PMID 22773862 DOI: 10.1016/J.Tetlet.2012.03.041  0.4
2012 Ghosh AK, Nicponski DR, Kass J. A Tandem Olefin Migration and Prins Cyclization Using Cu(OTf)(2)-Bisphosphine Complexes: An Improved Synthesis of Functionalized Tetrahydropyrans. Tetrahedron Letters. 53: 3699-3702. PMID 22753996 DOI: 10.1016/J.Tetlet.2012.04.006  0.76
2012 Ghosh AK, Martyr CD, Xu CX. TiCl4-promoted tandem carbonyl or imine addition and Friedel-Crafts cyclization: synthesis of benzo-fused oxabicyclooctanes and nonanes. Organic Letters. 14: 2002-5. PMID 22475177 DOI: 10.1021/Ol300494Q  0.446
2012 Chang YC, Yu X, Zhang Y, Tie Y, Wang YF, Yashchuk S, Ghosh AK, Harrison RW, Weber IT. Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring. Journal of Medicinal Chemistry. 55: 3387-97. PMID 22401672 DOI: 10.1021/Jm300072D  0.808
2012 Ghosh AK, Chapsal BD, Steffey M, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H. Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2308-11. PMID 22364812 DOI: 10.1016/J.Bmcl.2012.01.061  0.515
2012 Mandal SK, Ghosh AK, Kumar R, Zajc B. Expedient synthesis of α-substituted fluoroethenes. Organic & Biomolecular Chemistry. 10: 3164-7. PMID 22349519 DOI: 10.1039/C2Ob07031F  0.395
2012 Ghosh AK, Ren GB. Stereoselective synthesis of both tetrahydropyran rings of the antitumor macrolide, (-)-lasonolide A. The Journal of Organic Chemistry. 77: 2559-65. PMID 22324913 DOI: 10.1021/Jo202631E  0.408
2012 Ghosh AK, Anderson DD, Weber IT, Mitsuya H. Enhancing protein backbone binding--a fruitful concept for combating drug-resistant HIV. Angewandte Chemie (International Ed. in English). 51: 1778-802. PMID 22290878 DOI: 10.1002/Anie.201102762  0.424
2012 Li F, Chvyrkova I, Terzyan S, Wakeham N, Turner R, Ghosh AK, Zhang XC, Tang J. Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group. Applied Microbiology and Biotechnology. 94: 1041-9. PMID 22270239 DOI: 10.1007/S00253-012-3893-7  0.397
2012 Tie Y, Wang YF, Boross PI, Chiu TY, Ghosh AK, Tozser J, Louis JM, Harrison RW, Weber IT. Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors. Protein Science : a Publication of the Protein Society. 21: 339-50. PMID 22238126 DOI: 10.1002/Pro.2019  0.414
2012 Ghosh AK, Kass J. A stereoselective synthesis of (-)-viridiofungin A utilizing a TiCl(4)-promoted asymmetric multicomponent reaction. Organic Letters. 14: 510-2. PMID 22195730 DOI: 10.1021/Ol203093G  0.775
2012 Ghosh AK, Anderson DD, Weber IT, Mitsuya H. Verstärkung der Bindung an das Proteinrückgrat - ein fruchtbares Konzept gegen die Arzneimittelresistenz von HIV Angewandte Chemie. 124: 1812-1838. DOI: 10.1002/Ange.201102762  0.379
2011 Ghosh AK, Martyr CD, Steffey M, Wang YF, Agniswamy J, Amano M, Weber IT, Mitsuya H. Design of substituted bis-Tetrahydrofuran (bis-THF)-derived Potent HIV-1 Protease Inhibitors, Protein-ligand X-ray Structure, and Convenient Syntheses of bis-THF and Substituted bis-THF Ligands. Acs Medicinal Chemistry Letters. 2: 298-302. PMID 22509432 DOI: 10.1021/Ml100289M  0.533
2011 Koh Y, Aoki M, Danish ML, Aoki-Ogata H, Amano M, Das D, Shafer RW, Ghosh AK, Mitsuya H. Loss of protease dimerization inhibition activity of darunavir is associated with the acquisition of resistance to darunavir by HIV-1. Journal of Virology. 85: 10079-89. PMID 21813613 DOI: 10.1128/Jvi.05121-11  0.449
2011 Ghosh AK, Anderson DD. Tetrahydrofuran, tetrahydropyran, triazoles and related heterocyclic derivatives as HIV protease inhibitors. Future Medicinal Chemistry. 3: 1181-97. PMID 21806380 DOI: 10.4155/Fmc.11.68  0.443
2011 Ghosh AK, Chapsal BD, Parham GL, Steffey M, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H. Design of HIV-1 protease inhibitors with C3-substituted hexahydrocyclopentafuranyl urethanes as P2-ligands: synthesis, biological evaluation, and protein-ligand X-ray crystal structure. Journal of Medicinal Chemistry. 54: 5890-901. PMID 21800876 DOI: 10.1021/Jm200649P  0.516
2011 Ghosh AK, Nicponski DR. Cu(II)-catalyzed olefin migration and Prins cyclization: highly diastereoselective synthesis of substituted tetrahydropyrans. Organic Letters. 13: 4328-31. PMID 21797234 DOI: 10.1021/Ol2016675  0.374
2011 Ghosh AK, Cheng X. Enantioselective total synthesis of (-)-zampanolide, a potent microtubule-stabilizing agent. Organic Letters. 13: 4108-11. PMID 21749032 DOI: 10.1021/Ol201626H  0.437
2011 Ide K, Aoki M, Amano M, Koh Y, Yedidi RS, Das D, Leschenko S, Chapsal B, Ghosh AK, Mitsuya H. Novel HIV-1 protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran, that are potent against multi-PI-resistant HIV-1 variants. Antimicrobial Agents and Chemotherapy. 55: 1717-27. PMID 21282450 DOI: 10.1128/Aac.01540-10  0.452
2011 Ghosh AK, Chapsal BD, Baldridge A, Steffey MP, Walters DE, Koh Y, Amano M, Mitsuya H. Design and synthesis of potent HIV-1 protease inhibitors incorporating hexahydrofuropyranol-derived high affinity P(2) ligands: structure-activity studies and biological evaluation. Journal of Medicinal Chemistry. 54: 622-34. PMID 21194227 DOI: 10.1021/Jm1012787  0.512
2011 Ghosh AK, Li J. A stereoselective synthesis of (+)-herboxidiene/GEX1A. Organic Letters. 13: 66-9. PMID 21126066 DOI: 10.1021/Ol102549A  0.424
2011 Ghosh AK, Cheng X. Synthesis of (-)-Zampanolide Synfacts. 2011: 1050-1050. DOI: 10.1055/S-0030-1261145  0.403
2011 Ghosh AK, Martyr CD, Steffey M, Wang YF, Agniswamy J, Amano M, Weber IT, Mitsuya H. Design, synthesis, and X-ray structure of substituted bis-tetrahydrofuran (bis-THF)-derived potent HIV-1 protease inhibitors Acs Medicinal Chemistry Letters. 2: 298-302. DOI: 10.1021/ml100289m  0.418
2010 Nguyen TL, Xu X, Gussio R, Ghosh AK, Hamel E. The assembly-inducing laulimalide/peloruside a binding site on tubulin: molecular modeling and biochemical studies with [³H]peloruside A. Journal of Chemical Information and Modeling. 50: 2019-28. PMID 21028850 DOI: 10.1021/Ci1002894  0.466
2010 Ghosh AK. Capturing the essence of organic synthesis: from bioactive natural products to designed molecules in today's medicine. The Journal of Organic Chemistry. 75: 7967-89. PMID 20936876 DOI: 10.1021/Jo101606G  0.357
2010 Ghosh AK, Xu CX, Rao KV, Baldridge A, Agniswamy J, Wang YF, Weber IT, Aoki M, Miguel SG, Amano M, Mitsuya H. Probing multidrug-resistance and protein-ligand interactions with oxatricyclic designed ligands in HIV-1 protease inhibitors. Chemmedchem. 5: 1850-4. PMID 20827746 DOI: 10.1002/Cmdc.201000318  0.498
2010 Koh Y, Amano M, Towata T, Danish M, Leshchenko-Yashchuk S, Das D, Nakayama M, Tojo Y, Ghosh AK, Mitsuya H. In vitro selection of highly darunavir-resistant and replication-competent HIV-1 variants by using a mixture of clinical HIV-1 isolates resistant to multiple conventional protease inhibitors. Journal of Virology. 84: 11961-9. PMID 20810732 DOI: 10.1128/Jvi.00967-10  0.414
2010 Ghosh AK, Dawson ZL, Moon DK, Bai R, Hamel E. Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs. Bioorganic & Medicinal Chemistry Letters. 20: 5104-7. PMID 20678932 DOI: 10.1016/J.Bmcl.2010.07.023  0.814
2010 Ghosh AK, Yuan H. Enantioselective syntheses of the proposed structures of cytotoxic macrolides iriomoteolide-1a and -1b. Organic Letters. 12: 3120-3. PMID 20560539 DOI: 10.1021/Ol101105V  0.528
2010 Ghosh AK, Takayama J, Rao KV, Ratia K, Chaudhuri R, Mulhearn DC, Lee H, Nichols DB, Baliji S, Baker SC, Johnson ME, Mesecar AD. Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation. Journal of Medicinal Chemistry. 53: 4968-79. PMID 20527968 DOI: 10.1021/Jm1004489  0.43
2010 Nakata H, Kruhlak M, Kamata W, Ogata-Aoki H, Li J, Maeda K, Ghosh AK, Mitsuya H. Effects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine-CCR5 interactions. Antiviral Therapy. 15: 321-31. PMID 20516552 DOI: 10.3851/Imp1529  0.366
2010 Ghosh AK, Kass J. Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction. Chemical Communications (Cambridge, England). 46: 1218-20. PMID 20449255 DOI: 10.1039/B924807B  0.771
2010 Tojo Y, Koh Y, Amano M, Aoki M, Das D, Kulkarni S, Anderson DD, Ghosh AK, Mitsuya H. Novel protease inhibitors (PIs) containing macrocyclic components and 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane that are potent against multi-PI-resistant HIV-1 variants in vitro. Antimicrobial Agents and Chemotherapy. 54: 3460-70. PMID 20439612 DOI: 10.1128/Aac.01766-09  0.666
2010 Caron S, Wei L, Douville J, Ghosh A. Preparation and utility of trihaloethyl imidates: Useful reagents for the synthesis of amidines Journal of Organic Chemistry. 75: 945-947. PMID 20067229 DOI: 10.1021/Jo902159Z  0.37
2010 Ghosh AK, Gemma S, Simoni E, Baldridge A, Walters DE, Ide K, Tojo Y, Koh Y, Amano M, Mitsuya H. Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands. Bioorganic & Medicinal Chemistry Letters. 20: 1241-6. PMID 20034787 DOI: 10.1016/J.Bmcl.2009.11.123  0.52
2010 Singh AJ, Xu CX, Xu X, West LM, Wilmes A, Chan A, Hamel E, Miller JH, Northcote PT, Ghosh AK. Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity. The Journal of Organic Chemistry. 75: 2-10. PMID 19957922 DOI: 10.1021/Jo9021265  0.511
2010 Ghosh AK, Shurrush K, Kulkarni S. Synthesis of (-)-Tetrahydrolipstatin Synfacts. 2010: 6-6. DOI: 10.1055/S-0029-1218402  0.809
2010 Ghosh AK, Xi K. Formal Synthesis of (±)-Platencin Synfacts. 2010: 20-20. DOI: 10.1055/S-0029-1218396  0.515
2010 Ghosh AK, Xu C, Rao KV, Baldridge A, Agniswamy J, Wang Y, Weber IT, Aoki M, Miguel SGP, Amano M, Mitsuya H. Cover Picture: Probing Multidrug-Resistance and Protein-Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors (ChemMedChem 11/2010) Chemmedchem. 5: 1797-1797. DOI: 10.1002/Cmdc.201090049  0.419
2010 Ghosh AK, Shin D, Mathivanan P. ChemInform Abstract: Asymmetric Dihydroxylation Route to a Dipeptide Isostere of a Protease Inhibitor: Enantioselective Synthesis of the Core Unit of Ritonavir. Cheminform. 30: no-no. DOI: 10.1002/chin.199938182  0.333
2010 GHOSH AK, FIDANZE S. ChemInform Abstract: Transition-State Mimetics for HIV Protease Inhibitors: Stereocontrolled Synthesis of Hydroxyethylene and Hydroxyethylamine Isosteres by Ester-Derived Titanium Enolate syn and anti-Aldol Reactions. Cheminform. 30: no-no. DOI: 10.1002/chin.199905090  0.39
2010 GHOSH AK, CAPPIELLO J, SHIN D. ChemInform Abstract: Ring-Closing Metathesis Strategy to Unsaturated γ- and δ-Lactones: Synthesis of Hydroxyethylene Isostere for Protease Inhibitors. Cheminform. 29: no-no. DOI: 10.1002/chin.199838054  0.339
2010 GHOSH AK, FIDANZE S, ONISHI M, HUSSAIN KA. ChemInform Abstract: Ester Derived Titanium Enolate Aldol Reaction: Highly Diastereoselective Synthesis of syn- and anti-Aldols. Cheminform. 29: no-no. DOI: 10.1002/chin.199801075  0.306
2010 GHOSH AK, KINCAID JF, HASKE MG. ChemInform Abstract: A Convenient Enzymatic Route to Optically Active 1-Aminoindan-2-ol: Versatile Ligands for HIV-1 Protease Inhibitors and Asymmetric Syntheses. Cheminform. 28: no-no. DOI: 10.1002/chin.199741053  0.378
2010 GHOSH AK, KINCAID JF, WALTERS DE, CHEN Y, CHAUDHURI NC, THOMPSON WJ, CULBERSON C, FITZGERALD PMD, LEE HY, MCKEE SP, MUNSON PM, DUONG TT, DARKE PL, ZUGAY JA, SCHLEIF WA, et al. ChemInform Abstract: Nonpeptidal P2 Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation. Cheminform. 27: no-no. DOI: 10.1002/chin.199649167  0.407
2010 GHOSH AK, ONISHI M. ChemInform Abstract: Synthesis of Enantiomerically Pure Anti-Aldols: A Highly Stereoselective Ester-Derived Titanium Enolate Aldol Reaction. Cheminform. 27: no-no. DOI: 10.1002/chin.199628102  0.314
2010 GHOSH AK, LIU W. ChemInform Abstract: Chiral Auxiliary Mediated Conjugate Reduction and Asymmetric Protonation: Synthesis of High Affinity Ligands for HIV Protease Inhibitors. Cheminform. 27: no-no. DOI: 10.1002/chin.199606164  0.414
2010 GHOSH A, MILLER MJ. ChemInform Abstract: Synthesis of Novel Hydantoin Analogues of 5′-Nor Carbocyclic Nucleosides: Versatility of a Chiral Acylnitroso Cycloaddition. Cheminform. 27: no-no. DOI: 10.1002/chin.199603238  0.308
2010 GHOSH AK, LEE HY, THOMPSON WJ, CULBERSON C, HOLLOWAY MK, MCKEE SP, MUNSON PM, DUONG TT, SMITH AM, DARKE PL, ZUGAY JA, EMINI EA, SCHLEIF WA, HUFF JR, ANDERSON PS. ChemInform Abstract: The Development of Cyclic Sulfolanes as Novel and High-Affinity P2 Ligands for HIV-1 Protease Inhibitors. Cheminform. 25: no-no. DOI: 10.1002/chin.199433187  0.368
2010 GHOSH AK, MCKEE SP, THOMPSON WJ, DARKE PL, ZUGAY JC. ChemInform Abstract: Potent HIV-1 Protease Inhibitors: Stereoselective Synthesis of a Dipeptide Mimic. Cheminform. 24: no-no. DOI: 10.1002/chin.199322258  0.413
2010 THOMPSON WJ, GHOSH AK, HOLLOWAY MK, LEE HY, MUNSON PM, SCHWERING JE, WAI J, DARKE PL, ZUGAY J, EMINI EA, SCHLEIF WA, HUFF JR, ANDERSON PS. ChemInform Abstract: 3′-Tetrahydrofuranylglycine as a Novel, Unnatural Amino Acid Surrogate for Asparagine in the Design of Inhibitors of the HIV Protease. Cheminform. 24: no-no. DOI: 10.1002/chin.199321217  0.331
2010 GHOSH AK, MCKEE SP, THOMPSON WJ. ChemInform Abstract: Stereocontrolled Synthesis of HIV-1 Protease Inhibitors with C2-Axis of Symmetry. Cheminform. 23: no-no. DOI: 10.1002/chin.199224265  0.369
2010 GHOSH AK, MCKEE SP, THOMPSON WJ. ChemInform Abstract: An Efficient Synthesis of Hydroxyethylene Dipeptide Isosters: The Core Unit of Potent HIV-1 Protease Inhibitors. Cheminform. 23: no-no. DOI: 10.1002/chin.199213295  0.39
2010 Ghosh AK, Anderson DD, Mitsuya H. The FDA Approved HIV-1 Protease Inhibitors for Treatment of HIV/AIDS Burger's Medicinal Chemistry and Drug Discovery. 1-74. DOI: 10.1002/0471266949.Bmc224  0.431
2009 Ghosh AK, Dawson ZL. Synthesis of Bioactive Natural Products by Asymmetric - and -Aldol Reactions. Synthesis. 2009: 2992-3002. PMID 30443084 DOI: 10.1055/S-0029-1216941  0.804
2009 Ghosh AK, Yuan H. Stereoselective synthesis of the C(1)-C(12) segment of iriomoteolide 1a: a very potent macrolide antitumor agent. Tetrahedron Letters. 50: 1416-1418. PMID 20948581 DOI: 10.1016/J.Tetlet.2009.01.043  0.487
2009 Das D, Koh Y, Tojo Y, Ghosh AK, Mitsuya H. Prediction of potency of protease inhibitors using free energy simulations with polarizable quantum mechanics-based ligand charges and a hybrid water model. Journal of Chemical Information and Modeling. 49: 2851-62. PMID 19928916 DOI: 10.1021/Ci900320P  0.328
2009 Ghosh AK, Zajc B. Fluorinated 1-phenyl-1H-tetrazol-5-yl sulfone derivatives as general reagents for fluoroalkylidene synthesis. The Journal of Organic Chemistry. 74: 8531-40. PMID 19831343 DOI: 10.1021/Jo901313K  0.34
2009 Ghosh AK, Kulkarni S, Anderson DD, Hong L, Baldridge A, Wang YF, Chumanevich AA, Kovalevsky AY, Tojo Y, Amano M, Koh Y, Tang J, Weber IT, Mitsuya H. Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance. Journal of Medicinal Chemistry. 52: 7689-705. PMID 19746963 DOI: 10.1021/Jm900695W  0.706
2009 Fujimoto H, Higuchi M, Watanabe H, Koh Y, Ghosh AK, Mitsuya H, Tanoue N, Hamada A, Saito H. P-glycoprotein mediates efflux transport of darunavir in human intestinal Caco-2 and ABCB1 gene-transfected renal LLC-PK1 cell lines. Biological & Pharmaceutical Bulletin. 32: 1588-93. PMID 19721237 DOI: 10.1248/Bpb.32.1588  0.312
2009 Ghosh AK, Li J. An asymmetric total synthesis of brevisamide. Organic Letters. 11: 4164-7. PMID 19694486 DOI: 10.1021/Ol901691D  0.428
2009 Ghosh AK, Takayama J, Aubin Y, Ratia K, Chaudhuri R, Baez Y, Sleeman K, Coughlin M, Nichols DB, Mulhearn DC, Prabhakar BS, Baker SC, Johnson ME, Mesecar AD. Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease. Journal of Medicinal Chemistry. 52: 5228-40. PMID 19645480 DOI: 10.1021/Jm900611T  0.42
2009 Ghosh AK, Xi K. A symmetry-based concise formal synthesis of platencin, a novel lead against "superbugs". Angewandte Chemie (International Ed. in English). 48: 5372-5. PMID 19572306 DOI: 10.1002/Anie.200902338  0.617
2009 Ghosh AK, Leshchenko-Yashchuk S, Anderson DD, Baldridge A, Noetzel M, Miller HB, Tie Y, Wang YF, Koh Y, Weber IT, Mitsuya H. Design of HIV-1 protease inhibitors with pyrrolidinones and oxazolidinones as novel P1'-ligands to enhance backbone-binding interactions with protease: synthesis, biological evaluation, and protein-ligand X-ray studies. Journal of Medicinal Chemistry. 52: 3902-14. PMID 19473017 DOI: 10.1021/Jm900303M  0.505
2009 Ghosh AK, Shurrush K, Kulkarni S. Asymmetric synthesis of anti-aldol segments via a nonaldol route: synthetic applications to statines and (-)-tetrahydrolipstatin. The Journal of Organic Chemistry. 74: 4508-18. PMID 19438217 DOI: 10.1021/Jo900642F  0.819
2009 Ghosh AK, Xu CX. A convergent synthesis of the proposed structure of antitumor depsipeptide stereocalpin A. Organic Letters. 11: 1963-6. PMID 19354233 DOI: 10.1021/Ol900412U  0.43
2009 Ghosh AK. Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease. Journal of Medicinal Chemistry. 52: 2163-76. PMID 19323561 DOI: 10.1021/Jm900064C  0.463
2009 Ghosh AK, Xi K. Total synthesis of (-)-platensimycin, a novel antibacterial agent. The Journal of Organic Chemistry. 74: 1163-70. PMID 19123842 DOI: 10.1021/Jo802261F  0.623
2009 Koh Y, Das D, Leschenko S, Nakata H, Ogata-Aoki H, Amano M, Nakayama M, Ghosh AK, Mitsuya H. GRL-02031, a novel nonpeptidic protease inhibitor (PI) containing a stereochemically defined fused cyclopentanyltetrahydrofuran potent against multi-PI-resistant human immunodeficiency virus type 1 in vitro. Antimicrobial Agents and Chemotherapy. 53: 997-1006. PMID 18955518 DOI: 10.1128/Aac.00689-08  0.44
2009 Ghosh AK, Dawson ZL. Synthesis of bioactive natural products by asymmetric syn-and anti-aldol reactions Synthesis. 2992-3002. DOI: 10.1055/s-0029-1216941  0.798
2008 Ghosh AK, Kulkarni SS, Xu CX, Shurrush K. Asymmetric multi-component reactions: convenient access to acyclic stereocenters and functionalized cyclopentenoids. Tetrahedron, Asymmetry. 19: 1020-1026. PMID 21954322 DOI: 10.1016/J.Tetasy.2008.04.005  0.809
2008 Ghosh AK, Chapsal BD, Baldridge A, Ide K, Koh Y, Mitsuya H. Design and synthesis of stereochemically defined novel spirocyclic P2-ligands for HIV-1 protease inhibitors. Organic Letters. 10: 5135-8. PMID 18928291 DOI: 10.1021/Ol8020308  0.537
2008 Ratia K, Pegan S, Takayama J, Sleeman K, Coughlin M, Baliji S, Chaudhuri R, Fu W, Prabhakar BS, Johnson ME, Baker SC, Ghosh AK, Mesecar AD. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proceedings of the National Academy of Sciences of the United States of America. 105: 16119-24. PMID 18852458 DOI: 10.1073/Pnas.0805240105  0.397
2008 Ghosh AK, Gemma S, Takayama J, Baldridge A, Leshchenko-Yashchuk S, Miller HB, Wang YF, Kovalevsky AY, Koh Y, Weber IT, Mitsuya H. Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein-ligand X-ray studies. Organic & Biomolecular Chemistry. 6: 3703-13. PMID 18843400 DOI: 10.1039/B809178A  0.503
2008 del Solar M, Ghosh AK, Zajc B. Fluoro-Julia olefination as a mild, high-yielding route to alpha-fluoro acrylonitriles. The Journal of Organic Chemistry. 73: 8206-11. PMID 18841918 DOI: 10.1021/Jo801235X  0.355
2008 Kovalevsky AY, Louis JM, Aniana A, Ghosh AK, Weber IT. Structural evidence for effectiveness of darunavir and two related antiviral inhibitors against HIV-2 protease. Journal of Molecular Biology. 384: 178-92. PMID 18834890 DOI: 10.1016/J.Jmb.2008.09.031  0.457
2008 Ghosh AK, Kass J, Anderson DD, Xu X, Marian C. L-selectride-mediated highly diastereoselective asymmetric reductive aldol reaction: access to an important subunit for bioactive molecules. Organic Letters. 10: 4811-4. PMID 18831554 DOI: 10.1021/Ol801971T  0.761
2008 Kovalevsky AY, Ghosh AK, Weber IT. Solution kinetics measurements suggest HIV-1 protease has two binding sites for darunavir and amprenavir. Journal of Medicinal Chemistry. 51: 6599-603. PMID 18808097 DOI: 10.1021/Jm800283K  0.363
2008 Ghosh AK, Gong G, Grum-Tokars V, Mulhearn DC, Baker SC, Coughlin M, Prabhakar BS, Sleeman K, Johnson ME, Mesecar AD. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 5684-8. PMID 18796354 DOI: 10.1016/J.Bmcl.2008.08.082  0.437
2008 Ghosh AK, Gemma S, Baldridge A, Wang YF, Kovalevsky AY, Koh Y, Weber IT, Mitsuya H. Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies. Journal of Medicinal Chemistry. 51: 6021-33. PMID 18783203 DOI: 10.1021/Jm8004543  0.432
2008 Ghosh AK, Gong G. Total synthesis of potent antitumor agent (-)-lasonolide A: A cycloaddition-based strategy Chemistry - An Asian Journal. 3: 1811-1823. PMID 18712746 DOI: 10.1002/Asia.200800164  0.446
2008 Ghosh AK, Kulkarni S. Enantioselective total synthesis of (+)-largazole, a potent inhibitor of histone deacetylase. Organic Letters. 10: 3907-9. PMID 18662003 DOI: 10.1021/Ol8014623  0.652
2008 Liu F, Kovalevsky AY, Tie Y, Ghosh AK, Harrison RW, Weber IT. Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir. Journal of Molecular Biology. 381: 102-15. PMID 18597780 DOI: 10.1016/J.Jmb.2008.05.062  0.391
2008 Ghosh AK, Kumaragurubaran N, Hong L, Koelsh G, Tang J. Memapsin 2 (beta-secretase) inhibitors: drug development. Current Alzheimer Research. 5: 121-31. PMID 18393797 DOI: 10.2174/156720508783954730  0.318
2008 Ghosh AK, Xu X, Kim JH, Xu CX. Enantioselective total synthesis of peloruside A: a potent microtubule stabilizer. Organic Letters. 10: 1001-4. PMID 18247632 DOI: 10.1021/Ol703091B  0.509
2008 Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni S, Xu X, Miller HB, Reddy DS, Weerasena V, Turner R, Chang W, Koelsch G, Tang J. Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation. Bioorganic & Medicinal Chemistry Letters. 18: 1031-6. PMID 18180160 DOI: 10.1016/J.Bmcl.2007.12.028  0.69
2008 Mitsuya H, Maeda K, Das D, Ghosh AK. Development of protease inhibitors and the fight with drug-resistant HIV-1 variants. Advances in Pharmacology (San Diego, Calif.). 56: 169-97. PMID 18086412 DOI: 10.1016/S1054-3589(07)56006-0  0.394
2008 Ghosh AK, Chapsal BD, Weber IT, Mitsuya H. Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance. Accounts of Chemical Research. 41: 78-86. PMID 17722874 DOI: 10.1021/Ar7001232  0.49
2008 Ghosh AK, Takayama J. Corrigendum to “Enantioselective synthesis of cyclopentyltetrahydrofuran (Cp-THF), an important high-affinity P2-ligand for HIV-1 protease inhibitors”: [Tetrahedron Lett. 49 (2008) 3409] Tetrahedron Letters. 49: 6269. DOI: 10.1016/J.Tetlet.2008.08.053  0.468
2007 Ghosh AK, Xi K, Johnson ME, Baker SC, Mesecar AD. Progress in Anti-SARS Coronavirus Chemistry, Biology and Chemotherapy. Annual Reports in Medicinal Chemistry. 41: 183-196. PMID 19649165 DOI: 10.1016/S0065-7743(06)41011-3  0.598
2007 Ghosh AK, Lagisetty P, Zajc B. Direct synthesis of 8-fluoro purine nucleosides via metalation-fluorination. The Journal of Organic Chemistry. 72: 8222-6. PMID 17902691 DOI: 10.1021/Jo071121L  0.404
2007 Ghosh AK, Dawson ZL, Mitsuya H. Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV. Bioorganic & Medicinal Chemistry. 15: 7576-80. PMID 17900913 DOI: 10.1016/J.Bmc.2007.09.010  0.822
2007 Ghosh AK, Xi K, Grum-Tokars V, Xu X, Ratia K, Fu W, Houser KV, Baker SC, Johnson ME, Mesecar AD. Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 5876-80. PMID 17855091 DOI: 10.1016/J.Bmcl.2007.08.031  0.687
2007 Ghosh AK, Xi K. Enantioselective synthesis of (-)-platensimycin oxatetracyclic core by using an intramolecular Diels-Alder reaction. Organic Letters. 9: 4013-6. PMID 17764196 DOI: 10.1021/Ol701783Z  0.581
2007 Wang YF, Tie Y, Boross PI, Tozser J, Ghosh AK, Harrison RW, Weber IT. Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease. Journal of Medicinal Chemistry. 50: 4509-15. PMID 17696515 DOI: 10.1021/Jm070482Q  0.446
2007 Koh Y, Matsumi S, Das D, Amano M, Davis DA, Li J, Leschenko S, Baldridge A, Shioda T, Yarchoan R, Ghosh AK, Mitsuya H. Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization. The Journal of Biological Chemistry. 282: 28709-20. PMID 17635930 DOI: 10.1074/Jbc.M703938200  0.45
2007 Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni SS, Xu X, Chang W, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. Journal of Medicinal Chemistry. 50: 2399-407. PMID 17432843 DOI: 10.1021/Jm061338S  0.723
2007 Amano M, Koh Y, Das D, Li J, Leschenko S, Wang YF, Boross PI, Weber IT, Ghosh AK, Mitsuya H. A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro. Antimicrobial Agents and Chemotherapy. 51: 2143-55. PMID 17371811 DOI: 10.1128/Aac.01413-06  0.469
2007 Ghosh AK, Gong G. Enantioselective total synthesis of macrolide antitumor agent (-)-lasonolide A Organic Letters. 9: 1437-1440. PMID 17367152 DOI: 10.1021/Ol0701013  0.413
2007 Tie Y, Kovalevsky AY, Boross P, Wang YF, Ghosh AK, Tozser J, Harrison RW, Weber IT. Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir. Proteins. 67: 232-42. PMID 17243183 DOI: 10.1002/Prot.21304  0.415
2007 Ghosh AK, Kulkarni S, Xu CX, Fanwick PE. Asymmetric multicomponent reactions: diastereoselective synthesis of substituted pyrrolidines and prolines. Organic Letters. 8: 4509-11. PMID 16986937 DOI: 10.1021/Ol061672I  0.639
2007 Ghosh AK, Zajc B. High-yield synthesis of fluorinated benzothiazolyl sulfones: general synthons for fluoro-julia olefinations. Organic Letters. 8: 1553-6. PMID 16597108 DOI: 10.1021/Ol060002+  0.382
2007 Ghosh AK, Moon DK. Synthesis of (+)-Jasplakinolide Synfacts. 2007: 1013-1013. DOI: 10.1055/S-2007-968946  0.403
2007 Ghosh AK, Kulkarni S, Xu C, Fanwick PE. Asymmetric Multicomponent Reactions: Diastereoselective Synthesis of Substituted Pyrrolidines and Prolines. Cheminform. 38. DOI: 10.1002/chin.200704108  0.309
2006 Kovalevsky AY, Liu F, Leshchenko S, Ghosh AK, Louis JM, Harrison RW, Weber IT. Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114. Journal of Molecular Biology. 363: 161-73. PMID 16962136 DOI: 10.1016/J.Jmb.2006.08.007  0.42
2006 Ghosh AK, Ramu Sridhar P, Kumaragurubaran N, Koh Y, Weber IT, Mitsuya H. Bis-tetrahydrofuran: a privileged ligand for darunavir and a new generation of hiv protease inhibitors that combat drug resistance. Chemmedchem. 1: 939-50. PMID 16927344 DOI: 10.1002/Cmdc.200600103  0.468
2006 Ghosh AK, Sridhar PR, Leshchenko S, Hussain AK, Li J, Kovalevsky AY, Walters DE, Wedekind JE, Grum-Tokars V, Das D, Koh Y, Maeda K, Gatanaga H, Weber IT, Mitsuya H. Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance. Journal of Medicinal Chemistry. 49: 5252-61. PMID 16913714 DOI: 10.1021/Jm060561M  0.785
2006 Hamel E, Day BW, Miller JH, Jung MK, Northcote PT, Ghosh AK, Curran DP, Cushman M, Nicolaou KC, Paterson I, Sorensen EJ. Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly. Molecular Pharmacology. 70: 1555-64. PMID 16887932 DOI: 10.1124/Mol.106.027847  0.431
2006 Ghosh AK, Kumaragurubaran N, Hong L, Lei H, Hussain KA, Liu CF, Devasamudram T, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors. Journal of the American Chemical Society. 128: 5310-1. PMID 16620080 DOI: 10.1021/Ja058636J  0.397
2006 Ghosh AK, Schiltz G, Perali RS, Leshchenko S, Kay S, Walters DE, Koh Y, Maeda K, Mitsuya H. Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the P2'-ligands. Bioorganic & Medicinal Chemistry Letters. 16: 1869-73. PMID 16480871 DOI: 10.1016/J.Bmcl.2006.01.011  0.514
2006 Kovalevsky AY, Tie Y, Liu F, Boross PI, Wang YF, Leshchenko S, Ghosh AK, Harrison RW, Weber IT. Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M. Journal of Medicinal Chemistry. 49: 1379-87. PMID 16480273 DOI: 10.1021/Jm050943C  0.428
2006 Ghosh AK, Gong G. Total synthesis and revision of C6 stereochemistry of (+)-amphidinolide W Journal of Organic Chemistry. 71: 1085-1093. PMID 16438525 DOI: 10.1021/Jo052181Z  0.442
2006 Andresen BM, Caron S, Couturier M, DeVries KM, Do NM, Dupont-Gaudet K, Ghosh A, Girardin M, Hawkins JM, Makowski TM, Riou M, Sieser JE, Tucker JL, Vanderplas BC, Watson TJN. Process research and scale-up of the κ-opioid receptor agonist CJ-15,161 drug candidate Chimia. 60: 554-560. DOI: 10.2533/Chimia.2006.554  0.338
2006 Ghosh A, Kulkarni S, Xu C, Fanwick P. Diastereoselective Synthesis of Pyrrolidines and Prolines Synfacts. 2006: 1245-1245. DOI: 10.1055/S-2006-955639  0.641
2006 Ghosh A, Sieser J, Caron S, Couturier M, Dupont-Gaudet K, Girardin M. Synthesis of CJ-15,161 via Cu-Catalyzed N-Arylation Synfacts. 2006: 0533-0533. DOI: 10.1055/S-2006-934483  0.3
2006 Ghosh AK, Schiltz G, Perali RS, Leshchenko S, Kay S, Walters DE, Koh Y, Maeda K, Mitsuya H. Design and Synthesis of Novel HIV-1 Protease Inhibitors Incorporating Oxyindoles as the P2′-Ligands. Cheminform. 37. DOI: 10.1002/chin.200628215  0.408
2005 Gatanaga H, Das D, Suzuki Y, Yeh DD, Hussain KA, Ghosh AK, Mitsuya H. Altered HIV-1 Gag protein interactions with cyclophilin A (CypA) on the acquisition of H219Q and H219P substitutions in the CypA binding loop. The Journal of Biological Chemistry. 281: 1241-50. PMID 16275650 DOI: 10.1074/Jbc.M505920200  0.42
2005 Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD. Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors. Journal of Medicinal Chemistry. 48: 6767-71. PMID 16250632 DOI: 10.1021/Jm050548M  0.58
2005 Ghosh AK, Swanson LM, Cho H, Leshchenko S, Hussain KA, Kay S, Walters DE, Koh Y, Mitsuya H. Structure-based design: synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors. Journal of Medicinal Chemistry. 48: 3576-85. PMID 15887965 DOI: 10.1021/Jm050019I  0.56
2005 Turner RT, Hong L, Koelsch G, Ghosh AK, Tang J. Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase). Biochemistry. 44: 105-12. PMID 15628850 DOI: 10.1021/Bi048106K  0.313
2005 Ghosh AK, Xu CX, Kulkarni SS, Wink D. TiCl4-promoted multicomponent reaction: a new entry to functionalized alpha-amino acids. Organic Letters. 7: 7-10. PMID 15624964 DOI: 10.1021/Ol048302J  0.594
2005 Ghosh AK, Devasamudram T, Hong L, DeZutter C, Xu X, Weerasena V, Koelsch G, Bilcer G, Tang J. Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase). Bioorganic & Medicinal Chemistry Letters. 15: 15-20. PMID 15582402 DOI: 10.1016/J.Bmcl.2004.10.084  0.522
2005 Ghosh AK, Kim JH. Stereoselective chloroacetate aldol reactions: syntheses of acetate aldol equivalents and darzens glycidic esters. Organic Letters. 6: 2725-8. PMID 15281754 DOI: 10.1021/Ol0490835  0.382
2005 Ratia K, Santarsiero B, Xi K, Jukneliene D, Harcourt B, Baker S, Ghosh A, Mesecar A. Kinetic and crystallographic analyses of SARS coronavirus 3CLpro inhibitors Acta Crystallographica Section a Foundations of Crystallography. 61: c236-c236. DOI: 10.1107/S0108767305089944  0.572
2005 Kotha S, Khedkar P, Ghosh AK. Synthesis of Symmetrical Sulfones from Rongalite: Expansion to Cyclic Sulfones by Ring-Closing Metathesis European Journal of Organic Chemistry. 2005: 3581-3585. DOI: 10.1002/Ejoc.200500264  0.411
2004 Ghosh AK, Bischoff A. Asymmetric Syntheses of Potent Antitumor Macrolides Cryptophycin B and Arenastatin A. European Journal of Organic Chemistry. 2004: 2131-2141. PMID 30443158 DOI: 10.1002/Ejoc.200300814  0.413
2004 Ghosh AK, Leshchenko S, Noetzel M. Stereoselective photochemical 1,3-dioxolane addition to 5-alkoxymethyl-2(5H)-furanone: Synthesis of bis-tetrahydrofuranyl ligand for HIV protease inhibitor UIC-94017 (TMC-114) Journal of Organic Chemistry. 69: 7822-7829. PMID 15527257 DOI: 10.1021/Jo049156Y  0.535
2004 Ghosh AK, Xu X. Assignment of absolute stereochemistry and total synthesis of (-)-spongidepsin. Organic Letters. 6: 2055-8. PMID 15176817 DOI: 10.1021/ol049292p  0.478
2004 Couturier M, Ménard F, Ragan JA, Riou M, Dauphin E, Andresen BM, Ghosh A, Dupont-Gaudet K, Girardin M. Phosphine-mediated [4 + 2] annulation of bis(enones): a Lewis base catalyzed "mock Diels-Alder" reaction. Organic Letters. 6: 1857-60. PMID 15151432 DOI: 10.1021/Ol049392V  0.358
2004 Tie Y, Boross PI, Wang YF, Gaddis L, Hussain AK, Leshchenko S, Ghosh AK, Louis JM, Harrison RW, Weber IT. High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains. Journal of Molecular Biology. 338: 341-52. PMID 15066436 DOI: 10.1016/J.Jmb.2004.02.052  0.471
2004 Ghosh AK, Gong G. Total Synthesis and Structural Revision of (+)-Amphidinolide W Journal of the American Chemical Society. 126: 3704-3705. PMID 15038710 DOI: 10.1021/Ja049754U  0.409
2004 Ghosh AK, Swanson L. Enantioselective synthesis of (+)-cryptophycin 52 (LY355703), a potent antimitotic antitumor agent. The Journal of Organic Chemistry. 68: 9823-6. PMID 14656116 DOI: 10.1021/Jo035077V  0.436
2004 Kotha S, Ghosh AK. The Diels—Alder Approach for the Synthesis of Tetralin-Based α-Amino Acid Derivatives and Their Modification by the Suzuki—Miyaura Cross-Coupling Reaction. Cheminform. 35. DOI: 10.1055/S-2004-815987  0.376
2004 Kotha S, Ghosh AK, Deodhar KD. Synthesis of Symmetrical and Unsymmetrical 9,10-Diarylanthracene Derivatives via Bis-Suzuki—Miyaura Cross-Coupling Reaction. Cheminform. 35. DOI: 10.1055/S-2004-815981  0.373
2004 Ghosh AK, Liu C. Chapter 9 First total synthesis of (+)-Amphidinolide T1 Strategies and Tactics in Organic Synthesis. 5: 255-302. DOI: 10.1016/S1874-6004(04)80032-7  0.42
2003 Ghosh AK, Kim JH. Synthetic studies of microtubule stabilizing agent peloruside A: an asymmetric synthesis of C-C segment. Tetrahedron Letters. 44: 7659-7661. PMID 30443085 DOI: 10.1016/J.Tetlet.2003.08.023  0.396
2003 Ghosh AK, Bischoff A, Cappiello J. Asymmetric Total Synthesis of the Gastroprotective Microbial Agent AI-77-B. European Journal of Organic Chemistry. 2003: 821-832. PMID 30393460 DOI: 10.1002/Ejoc.200390125  0.428
2003 Ghosh AK, Lei H. An enantioselective synthesis of the core unit of the non-nucleoside reverse transcriptase inhibitor taurospongin A. Tetrahedron, Asymmetry. 14: 629-634. PMID 30393445 DOI: 10.1016/S0957-4166(03)00040-5  0.382
2003 Ghosh AK, Kim JH. An enantioselective synthesis of the C-C segment of antitumor macrolide peloruside A. Tetrahedron Letters. 44: 3967-3969. PMID 30393410 DOI: 10.1016/S0040-4039(03)00744-5  0.372
2003 Koh Y, Nakata H, Maeda K, Ogata H, Bilcer G, Devasamudram T, Kincaid JF, Boross P, Wang YF, Tie Y, Volarath P, Gaddis L, Harrison RW, Weber IT, Ghosh AK, et al. Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrobial Agents and Chemotherapy. 47: 3123-9. PMID 14506019 DOI: 10.1128/Aac.47.10.3123-3129.2003  0.421
2003 Tang J, Ghosh AK, Hong L, Koelsch G, Turner RT, Chang W. Study of memapsin 2 (beta-secretase) and strategy of inhibitor design. Journal of Molecular Neuroscience : Mn. 20: 299-304. PMID 14501012 DOI: 10.1385/Jmn:20:3:299  0.32
2003 Ghosh AK, Kim JH. Highly diastereoselective anti-aldol reactions utilizing the titanium enolate of cis-2-arylsulfonamido-1- acenaphthenyl propionate. Organic Letters. 5: 1063-6. PMID 12659574 DOI: 10.1021/Ol034086N  0.351
2003 Ghosh AK, Liu C. Enantioselective total synthesis of (+)-amphidinolide t1. Journal of the American Chemical Society. 125: 2374-5. PMID 12603108 DOI: 10.1021/Ja021385J  0.332
2003 Ghosh AK, Lei H. Chelation-controlled reduction: stereoselective formation of syn-1,3-diols and synthesis of compactin and mevinolin lactone. The Journal of Organic Chemistry. 67: 8783-8. PMID 12467389 DOI: 10.1021/Jo020402K  0.369
2003 Hong L, Turner RT, Koelsch G, Ghosh AK, Tang J. Memapsin 2 (beta-secretase) as a therapeutic target. Biochemical Society Transactions. 30: 530-4. PMID 12196130 DOI: 10.1042/Bst0300530  0.304
2002 Ghosh AK, Kim JH. Chelation-controlled ester-derived titanium enolate aldol reaction: diastereoselective -aldols with mono- and bidentate aldehydes. Tetrahedron Letters. 43: 5621-5624. PMID 30449907 DOI: 10.1016/S0040-4039(02)01113-9  0.411
2002 Ghosh AK, Lei H. Stereoselective Synthesis of the C-N Fragment of Griseoviridin. Synthesis. 2002: 371-374. PMID 30449904 DOI: 10.1055/S-2002-20037  0.353
2002 Ghosh AK, Shin D, Schiltz G. MULTICOMPONENT REACTIONS: SYNTHESIS OF SPIROCYCLIC TETRAHYDROPYRAN DERIVATIVES BY PRINS CYCLIZATION. Heterocycles. 58: 659-666. PMID 30393424 DOI: 10.3987/Com-02-S(M)63  0.404
2002 Mc Henry KT, Ankala SV, Ghosh AK, Fenteany G. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. Chembiochem : a European Journal of Chemical Biology. 3: 1105-11. PMID 12404636 DOI: 10.1002/1439-7633(20021104)3:11<1105::Aid-Cbic1105>3.0.Co;2-S  0.692
2002 Hong L, Turner RT, Koelsch G, Shin D, Ghosh AK, Tang J. Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3. Biochemistry. 41: 10963-7. PMID 12206667 DOI: 10.1021/Bi026232N  0.35
2002 Pryor DE, O'Brate A, Bilcer G, Díaz JF, Wang Y, Wang Y, Kabaki M, Jung MK, Andreu JM, Ghosh AK, Giannakakou P, Hamel E. The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity. Biochemistry. 41: 9109-15. PMID 12119025 DOI: 10.1021/Bi020211B  0.323
2002 Ghosh AK, Swanson LM, Liu C, Hussain KA, Cho H, Walters DE, Holland L, Buthod J. Novel cyclourethane-derived HIV protease inhibitors: a ring-closing olefin metathesis based strategy. Bioorganic & Medicinal Chemistry Letters. 12: 1993-6. PMID 12113826 DOI: 10.1016/S0960-894X(02)00300-1  0.482
2002 Ghosh AK, Hong L, Tang J. Beta-secretase as a therapeutic target for inhibitor drugs. Current Medicinal Chemistry. 9: 1135-44. PMID 12052177 DOI: 10.2174/0929867023370149  0.359
2002 Ghosh AK, Pretzer E, Cho H, Hussain KA, Düzgüneş N. Antiviral activity of UIC-PI, a novel inhibitor of the human immunodeficiency virus type 1 protease. Antiviral Research. 54: 29-36. PMID 11888655 DOI: 10.1016/S0166-3542(01)00209-1  0.429
2002 Yoshimura K, Kato R, Kavlick MF, Nguyen A, Maroun V, Maeda K, Hussain KA, Ghosh AK, Gulnik SV, Erickson JW, Mitsuya H. A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site. Journal of Virology. 76: 1349-58. PMID 11773409 DOI: 10.1128/JVI.76.3.1349-1358.2002  0.346
2002 Ghosh AK, Wang Y, Kim JT. Total synthesis of microtubule-stabilizing agent (-)-laulimalide. The Journal of Organic Chemistry. 66: 8973-82. PMID 11749630 DOI: 10.1021/Jo010854H  0.347
2002 Kotha S, Ghosh AK. Synthesis of 9,10-Diarylanthracene Derivatives via bis Suzuki-Miyaura Cross-coupling Reaction Synlett. 2002: 0451-0452. DOI: 10.1055/S-2002-20463  0.393
2001 Ghosh AK, Kim JH. Ester derived titanium enolate aldol reaction: chelation controlled diastereoselective synthesis of -aldols. Tetrahedron Letters. 42: 1227-1231. PMID 31303686 DOI: 10.1016/S0040-4039(00)02227-9  0.415
2001 Ghosh AK, Wang Y. A macrolactonization-based strategy to obtain microtuble-stabilizing agent (-)-laulimalide. Tetrahedron Letters. 42: 3399-3401. PMID 30464359 DOI: 10.1016/S0040-4039(01)00436-1  0.361
2001 Ghosh AK, Shirai M. Asymmetric hetero Diels-Alder route to quaternary carbon centers: synthesis of (-)-malyngolide. Tetrahedron Letters. 42: 6231-6233. PMID 30393409 DOI: 10.1016/S0040-4039(01)01227-8  0.383
2001 Ghosh AK, Koltun ES, Bilcer G. Tartaric Acid and Tartrates in the Synthesis of Bioactive Molecules. Synthesis. 2001: 1281-1301. PMID 30393405 DOI: 10.1055/S-2001-15217  0.341
2001 Ghosh AK, Bilcer G, Schiltz G. Syntheses of FDA Approved HIV Protease Inhibitors. Synthesis. 2001: 2203-2229. PMID 30393404 DOI: 10.1055/S-2001-18434  0.423
2001 Ghosh AK, Bilcer G, Harwood C, Kawahama R, Shin D, Hussain KA, Hong L, Loy JA, Nguyen C, Koelsch G, Ermolieff J, Tang J. Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase). Journal of Medicinal Chemistry. 44: 2865-8. PMID 11520194 DOI: 10.1021/Jm0101803  0.302
2001 Ghosh AK, Bischoff A, Cappiello J. Stereoselective synthesis of pseudopeptide microbial agent AI-77-B. Organic Letters. 3: 2677-80. PMID 11506607 DOI: 10.1021/Ol0101279  0.41
2001 Ghosh AK, Shin D, Swanson L, Krishnan K, Cho H, Hussain KA, Walters DE, Holland L, Buthod J. Structure-based design of non-peptide HIV protease inhibitors. Farmaco (Società Chimica Italiana : 1989). 56: 29-32. PMID 11347961 DOI: 10.1016/S0014-827X(01)01025-4  0.476
2001 Ghosh AK, Liu C. Total synthesis of antitumor depsipeptide (-)-doliculide. Organic Letters. 3: 635-8. PMID 11178844 DOI: 10.1021/Ol0100069  0.445
2000 Ghosh AK, Bilcer G. A stereoselective synthesis of (+)-boronolide. Tetrahedron Letters. 41: 1003-1006. PMID 30449906 DOI: 10.1016/S0040-4039(99)02246-7  0.39
2000 Ghosh AK, Wang Y. Synthetic studies of antitumor macrolide laulimalide: a stereoselective synthesis of the C-C segment. Tetrahedron Letters. 41: 4705-4708. PMID 30405275 DOI: 10.1016/S0040-4039(00)00715-2  0.319
2000 Ghosh AK, Wang Y. An enantioselective synthesis of the C-C segment of antitumor macrolide laulimalide. Tetrahedron Letters. 41: 2319-2322. PMID 30393407 DOI: 10.1016/S0040-4039(00)00158-1  0.387
2000 Chakraborty TK, Ghosh S, Rao MHVR, Kunwar AC, Cho H, Ghosh AK. 2,5-Anhydro sugar diacid and 2,5-anhydro sugar diamine based symmetric peptidomimetics as potential HIV-1 protease inhibitors. Tetrahedron Letters. 41: 10121-10125. PMID 30386001 DOI: 10.1016/S0040-4039(00)01803-7  0.653
2000 Hong L, Koelsch G, Lin X, Wu S, Terzyan S, Ghosh AK, Zhang XC, Tang J. Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science (New York, N.Y.). 290: 150-3. PMID 11021803 DOI: 10.1126/Science.290.5489.150  0.34
2000 Ghosh AK, Kawahama R. A short synthesis of (+/-)-eburnamonine. The Journal of Organic Chemistry. 65: 5433-5. PMID 10993380 DOI: 10.1021/Jo000507S  0.376
2000 Ghosh AK, Lei H. Enzymatic acylation and ring-closing olefin metathesis: a convenient strategy for the lactone moiety of compactin and mevinolin. The Journal of Organic Chemistry. 65: 4779-81. PMID 10959897 DOI: 10.1021/Jo000528M  0.374
2000 Ghosh AK, Fidanze S. Asymmetric synthesis of (-)-tetrahydrolipstatin: an anti-aldol-based strategy. Organic Letters. 2: 2405-7. PMID 10956507 DOI: 10.1021/Ol000070A  0.414
2000 Kotha S, Ganesh T, Ghosh AK. Diels-Alder approach to tetralin-based constrained α-amino acid derivatives Bioorganic and Medicinal Chemistry Letters. 10: 1755-1757. PMID 10937741 DOI: 10.1016/S0960-894X(00)00333-4  0.317
2000 Ghosh AK, Bischoff A. A convergent synthesis of (+)-cryptophycin B, a potent antitumor macrolide from Nostoc sp. cyanobacteria. Organic Letters. 2: 1573-5. PMID 10841482 DOI: 10.1021/Ol000058I  0.404
1999 Ghosh AK, Kawahama R. TiC1 promoted three component coupling reaction: an efficient method for the substituted tetrahydropyrilidene acetates. Tetrahedron Letters. 40: 4751-4754. PMID 30468361 DOI: 10.1016/S0040-4039(99)00811-4  0.322
1999 Ghosh AK, Kawahama R. TiCl Promoted Three Component Coupling Reaction : A New Method for the Synthesis of Functionalized Tetrahydrofurans and Tetrahydropyrans. Tetrahedron Letters. 40: 1083-1086. PMID 30422132 DOI: 10.1016/S0040-4039(98)02633-1  0.35
1999 Ghosh AK, Liu C. A stereoselective synthesis of (-)-tetrahydrolipstatin. Chemical Communications (Cambridge, England). 1999: 1743-1744. PMID 30416366 DOI: 10.1039/A904533C  0.425
1999 Ghosh AK, Wang Y. Stereoselective Synthesis of 5--Carbamoylpolyoxamic Acid by [2,3]-Wittig-Still Rearrangement. Tetrahedron. 55: 13369-13376. PMID 30405274 DOI: 10.1016/S0040-4020(99)00838-8  0.357
1999 Ghosh AK, Shin D, Mathivanan P. Asymmetric dihydroxylation route to a dipeptide isostere of a protease inhibitor: enantioselective synthesis of the core unit of ritonavir. Chemical Communications (Cambridge, England). 1999: 1025-1026. PMID 30364548 DOI: 10.1039/A902518I  0.468
1999 Ghosh AK, Wang Y. Synthetic studies of nucleoside antibiotics: a formal synthesis of (+)-sinefungin. Journal of the Chemical Society. Perkin Transactions 1. 1999: 3597-3601. PMID 30344366 DOI: 10.1039/A907228D  0.418
1998 Ghosh AK, Mathivanan P, Cappiello J. -Symmetric chiral bis(oxazoline)-metal complexes in catalytic asymmetric synthesis. Tetrahedron, Asymmetry. 9: 1-45. PMID 30457575 DOI: 10.1016/S0957-4166(97)00593-4  0.438
1998 Ghosh AK, Cho H, Cappiello J. Bis(oxazoline) derived cationic aqua complexes: highly effective catalysts for enantioselective Diels-Alder reactions. Tetrahedron, Asymmetry. 9: 3687-3691. PMID 30449952 DOI: 10.1016/S0957-4166(98)00362-0  0.342
1998 Ghosh AK, Cappiello J. Stereoselective Synthesis of Dihydroisocoumarin Moiety of Microbial Agent AI-77-B: a Diels-Alder Based Strategy. Tetrahedron Letters. 39: 8803-8806. PMID 30422131 DOI: 10.1016/S0040-4039(98)01977-7  0.398
1998 Ghosh AK, Cappiello J, Shin D. RING-CLOSING METATHESIS STRATEGY TO UNSATURATED γ- AND δ-LACTONES: SYNTHESIS OF HYDROXYETHYLENE ISOSTERE FOR PROTEASE INHIBITORS. Tetrahedron Letters. 39: 4651-4654. PMID 30422130 DOI: 10.1016/S0040-4039(98)00887-9  0.39
1998 Ghosh AK, Fidanze S, Senanayake CH. -1-Aminoindan-2-ol in Asymmetric Syntheses. Synthesis. 1998: 937-961. PMID 30393403 DOI: 10.1055/S-1998-2092  0.381
1998 Ghosh AK, Hussain KA. Convenient synthesis of novel macrocyclic urethanes: alkoxycarbonylation of amines and ring-closing metathesis strategy. Tetrahedron Letters. 39: 1881-1884. PMID 30383041 DOI: 10.1016/S0040-4039(98)00153-1  0.365
1998 Ghosh AK, Wang Y. Stereoselective Synthesis of Protected Thymine Polyoxin C via [2,3]-Wittig-Still Rearrangement of Ribose-Derived Allylic Stannyl Ethers. The Journal of Organic Chemistry. 63: 6735-6738. PMID 30338957 DOI: 10.1021/Jo9808066  0.401
1998 Ghosh AK, Kincaid JF, Cho W, Walters DE, Krishnan K, Hussain KA, Koo Y, Cho H, Rudall C, Holland L, Buthod J. Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere. Bioorganic & Medicinal Chemistry Letters. 8: 687-90. PMID 9871583 DOI: 10.1016/S0960-894X(98)00098-5  0.496
1998 Ghosh AK, Krishnan K, Walters DE, Cho W, Cho H, Koo Y, Trevino J, Holland L, Buthod J. Structure based design: novel spirocyclic ethers as nonpeptidal P2-ligands for HIV protease inhibitors. Bioorganic & Medicinal Chemistry Letters. 8: 979-82. PMID 9871524 DOI: 10.1016/S0960-894X(98)00139-5  0.486
1997 Ghosh AK, Fidanze S, Onishi M, Hussain KA. ESTER DERIVED TITANIUM ENOLATE ALDOL REACTION: HIGHLY DIASTEREOSELECTIVE SYNTHESIS OF SYN- AND ANTI-ALDOLS. Tetrahedron Letters. 38: 7171-7174. PMID 30407471 DOI: 10.1016/S0040-4039(97)01765-6  0.402
1997 Ghosh AK, Kincaid JF, Haske MG. A Convenient Enzymatic Route to Optically Active l-Aminoindan-2-ol: Versatile Ligands for HIV-1 Protease Inhibitors and Asymmetric Syntheses. Synthesis. 1997: 541-544. PMID 30393402 DOI: 10.1055/S-1997-1235  0.402
1997 Ghosh AK, Cho H, Onishi M. Asymmetric alkylations and aldol reactions: (1,2)-2-aminocyclopentan-1-ol derived new chiral auxiliary. Tetrahedron, Asymmetry. 8: 821-824. PMID 30387787 DOI: 10.1016/S0957-4166(97)00065-7  0.389
1997 Ghosh AK, Mathivanan P, Cappiello J. SYNTHETIC STUDIES OF ANTITUMOR MACROLIDE LAULIMALIDE: ENANTIOSELECTIVE SYNTHESIS OF THE C-C SEGMENT BY A CATALYTIC HETERO DIELS-ALDER STRATEGY. Tetrahedron Letters. 38: 2427-2430. PMID 30344352 DOI: 10.1016/S0040-4039(97)00416-4  0.361
1996 Ghosh AK, Mathivanan P, Cappiello J. Conformationally Constrained Bis(oxazoline) Derived Chiral Catalyst : A Highly Effective Enantioselective Diels-Alder Reaction. Tetrahedron Letters. 37: 3815-3818. PMID 30411722 DOI: 10.1016/0040-4039(96)00721-6  0.371
1996 Ghosh AK, Mathivanan P, Cappiello J, Krishnan K. ASYMMETRIC HETERO DIELS-ALDER REACTIONS OF DANISHEFSKY'S DIENE AND GLYOXYLATE ESTERS CATALYZED BY CHIRAL BISOXAZOLINE DERIVED CATALYSTS. Tetrahedron, Asymmetry. 7: 2165-2168. PMID 30395656 DOI: 10.1016/0957-4166(96)00261-3  0.386
1996 Ghosh AK, Onishi M. Synthesis of Enantiomerically Pure Anti-Aldols: A Highly Stereoselective Ester-Derived Titanium Enolate Aldol Reaction. Journal of the American Chemical Society. 118: 2527-2528. PMID 30385889 DOI: 10.1021/Ja9539148  0.427
1996 Ghosh AK, Mathivanan P. ASYMMETRIC DIELS-ALDER REACTION : CIS-1-ARYLSULFONAMIDO-2-INDANOLS AS HIGHLY EFFECTIVE CHIRAL AUXILIARIES. Tetrahedron, Asymmetry. 7: 375-378. PMID 30382247 DOI: 10.1016/0957-4166(96)00010-9  0.352
1996 Ghosh AK, Liu W, Xu Y, Chen Z. A Convergent, Enantioselective Total Synthesis of Hapalosin: A Drug with Multidrug-Resistance Reversing Activity. Angewandte Chemie (International Ed. in English). 35: 74-76. PMID 30344446 DOI: 10.1002/Anie.199600741  0.336
1996 Ghosh AK, Kincaid JF, Walters DE, Chen Y, Chaudhuri NC, Thompson WJ, Culberson C, Fitzgerald PM, Lee HY, McKee SP, Munson PM, Duong TT, Darke PL, Zugay JA, Schleif WA, et al. Nonpeptidal P2 ligands for HIV protease inhibitors: structure-based design, synthesis, and biological evaluation. Journal of Medicinal Chemistry. 39: 3278-90. PMID 8765511 DOI: 10.1021/Jm960128K  0.52
1995 Ghosh AK, Chen Y. HIGHLY STEREOSELECTIVE REDUCTION OF α-KETO ESTERS: UTILITY OF CIS-1-ARYLSULFONAMIDO-2-INDANOLS AS CHIRAL AUXILIARIES. Tetrahedron Letters. 36: 6811-6814. PMID 30393406 DOI: 10.1016/0040-4039(95)01385-U  0.309
1995 Ghosh AK, Liu W. Chiral Auxiliary Mediated Conjugate Reduction and Asymmetric Protonation: Synthesis of High Affinity Ligands for HIV Protease Inhibitors. The Journal of Organic Chemistry. 60: 6198-6201. PMID 30344339 DOI: 10.1021/Jo00124A042  0.511
1995 Ghosh AK, Chen Y. SYNTHESIS AND OPTICAL RESOLUTION OF HIGH AFFINITY P-LIGANDS FOR HIV-1 PROTEASE INHIBITORS. Tetrahedron Letters. 36: 505-508. PMID 30310245 DOI: 10.1016/0040-4039(94)02296-N  0.43
1995 Ghosh AK, Thompson WJ, Munson PM, Liut W, Huff JR. CYCLIC SULFONE-3-CARBOXAMIDES AS NOVEL P-LIGANDS FOR Ro 31-8959 BASED HIV-1 PROTEASE INHIBITORS. Bioorganic & Medicinal Chemistry Letters. 5: 83-88. PMID 30294073 DOI: 10.1016/0960-894X(94)00463-P  0.432
1995 Ghosh A, Ritter AR, Miller MJ. Synthesis of enantiomerically pure 5'-aza-noraristeromycin analogs The Journal of Organic Chemistry. 60: 5808-5813. DOI: 10.1021/Jo00123A015  0.428
1995 Ghosh A, Miller MJ. Synthesis of novel hydantoin analogs of 5′-nor carbocyclic nucleosides: Versatility of a chiral acylnitroso cycloaddition Tetrahedron Letters. 36: 6399-6402. DOI: 10.1016/0040-4039(95)01323-A  0.347
1994 Ghosh AK, Lee HY, Thompson WJ, Culberson C, Holloway MK, McKee SP, Munson PM, Duong TT, Smith AM, Darke PL. The development of cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors. Journal of Medicinal Chemistry. 37: 1177-88. PMID 8164260 DOI: 10.1021/Jm00034A016  0.509
1994 Ghosh AK, Thompson WJ, Fitzgerald PM, Culberson JC, Axel MG, McKee SP, Huff JR, Anderson PS. Structure-based design of HIV-1 protease inhibitors: replacement of two amides and a 10 pi-aromatic system by a fused bis-tetrahydrofuran. Journal of Medicinal Chemistry. 37: 2506-8. PMID 8057296 DOI: 10.1021/Jm00042A002  0.472
1994 Szmuszkovicz J, Zhao S, Ghosh A, V. D'Andrea S, P. Freeman J, F. VonVoigtlander P, B. Carter D, W. Smith M, R. Blinn J. Synthetic Studies towards A trans-3,4-Diamine Derivative of Piperidine Mimicking Buspirone Heterocycles. 39: 163. DOI: 10.3987/Com-93-S(B)12  0.384
1993 Thompson WJ, Ghosh AK, Holloway MK, Lee HY, Munson PM, Schwering JE, Wai J, Darke PL, Zugay J, Emini EA, Schleif WA, Huff JR, Anderson PS. 3'-Tetrahydrofuranylglycine as a Novel, Unnatural Amino Acid Surrogate for Asparagine in the Design of Inhibitors of the HIV Protease. Journal of the American Chemical Society. 115: 801-803. PMID 30364398 DOI: 10.1021/Ja00055A069  0.429
1993 Ghosh AK, McKee SP, Thompson WJ, Darke PL, Zugay JC. Potent HIV-1 Protease Inhibitors: Stereoselective Synthesis of a Dipeptide Mimic. The Journal of Organic Chemistry. 58: 1025-1029. PMID 30310240 DOI: 10.1021/Jo00057A011  0.552
1993 Ghosh AK, Thompson WJ, Lee HY, McKee SP, Munson PM, Duong TT, Darke PL, Zugay JA, Emini EA, Schleif WA. Cyclic sulfolanes as novel and high affinity P2 ligands for HIV-1 protease inhibitors. Journal of Medicinal Chemistry. 36: 924-7. PMID 8464047 DOI: 10.1021/jm00059a019  0.362
1993 Ghosh AK, Thompson WJ, McKee SP, Duong TT, Lyle TA, Chen JC, Darke PL, Zugay JA, Emini EA, Schleif WA. 3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors. Journal of Medicinal Chemistry. 36: 292-4. PMID 8423600 DOI: 10.1021/jm00054a015  0.346
1993 Ghosh AK, Thompson WJ, Holloway MK, McKee SP, Duong TT, Lee HY, Munson PM, Smith AM, Wai JM, Darke PL. Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands. Journal of Medicinal Chemistry. 36: 2300-10. PMID 8360874 DOI: 10.1021/jm00068a006  0.331
1993 Ghosh A, Miller MJ. Synthesis of novel citrate-based siderophores and siderophore-.beta.-lactam conjugates. Iron transport-mediated drug delivery systems The Journal of Organic Chemistry. 58: 7652-7659. DOI: 10.1021/Jo00079A007  0.343
1992 Ghosh AK, McKee SP, Lee HY, Thompson WJ. A Facile and Enantiospecific Synthesis of 2()- and 2()-[1'()-Azido-2-phenylethyl]oxirane. Journal of the Chemical Society. Chemical Communications. 1992: 273-274. PMID 30319147 DOI: 10.1039/C39920000273  0.369
1992 Corey EJ, Rao KS, Ghosh AK. INTRAMOLECULAR AND INTERMOLECULAR HYDROXYL REACTIVITY DIFFERENCES IN GINKGOLIDES A, B AND C AND THEIR CHEMICAL APPLICATIONS. Tetrahedron Letters. 33: 6955-6958. PMID 30310244 DOI: 10.1016/S0040-4039(00)60905-X  0.494
1992 Ghosh AK, McKee SP, Duong TT, Thompson WJ. An Efficient Synthesis of Functionalized Urethanes from Azides. Journal of the Chemical Society. Chemical Communications. 1992: 1308-1310. PMID 30305769 DOI: 10.1039/C39920001308  0.328
1992 Ghosh AK, Duong TT, McKee SP. Highly enantioselective aldol reaction: Development of a new chiral auxiliary from cis-1-amino-2-hydroxyindan Journal of the Chemical Society, Chemical Communications. 1673-1674. DOI: 10.1039/C39920001673  0.375
1992 Nath A, Ghosh A, Venkateswaran RV. Rapid, high-yield synthesis of the marine sesquiterpenes debromoaplysin and aplysin via the acid-catalyzed rearrangement of a cyclobutachromanol The Journal of Organic Chemistry. 57: 1467-1472. DOI: 10.1021/Jo00031A026  0.402
1991 Ghosh AK, McKee SP, Thompson WJ. An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors. The Journal of Organic Chemistry. 56: 6500-6503. PMID 30393394 DOI: 10.1021/Jo00023A009  0.497
1991 Ghosh AK, McKee SP, Thompson WJ. STEREOCONTROLLED SYNTHESIS OF HIV-l PROTEASE INHIBITORS WITH C-AXIS OF SYMMETRY. Tetrahedron Letters. 32: 5729-5732. PMID 30310242 DOI: 10.1016/S0040-4039(00)93541-X  0.456
1991 Ghosh AK, Duong TT, McKee SP. Di(2-pyridyl) carbonate promoted alkoxycarbonylation of amines: A convenient synthesis of functionalized carbamates Tetrahedron Letters. 32: 4251-4254. DOI: 10.1016/S0040-4039(00)92141-5  0.327
1990 Biswas S, Ghosh A, Venkateswaran RV. Stereocontrolled synthesis of (.+-.)-debromoaplysin, (.+-.)-aplysin, (.+-.)-debromoaplysinol, (.+-.)-aplysinol, and (.+-.)-isoaplysin The Journal of Organic Chemistry. 55: 3498-3502. DOI: 10.1021/Jo00298A022  0.305
1988 Corey EJ, Ghosh AK. TOTAL SYNTHESIS OF GINKGOLIDE A. Tetrahedron Letters. 29: 3205-3206. PMID 31595095 DOI: 10.1016/0040-4039(88)85122-0  0.551
1988 Corey EJ, Kang MC, Desai MC, Ghosh AK, Houpis IN. Total Synthesis of (±)-Ginkgolide B. Journal of the American Chemical Society. 110: 649-651. PMID 31527923 DOI: 10.1021/Ja00210A083  0.5
1988 Ghosh A, Biswas S, Venkateswaran RV. Stereocontrolled synthesis of (±)-debromoaplysin and (±)-aplysin Journal of the Chemical Society, Chemical Communications. 1421-1421. DOI: 10.1039/C39880001421  0.321
1987 Corey EJ, Ghosh AK. Two-Step Synthesis of Furans by Mn(III)-Promoted Annulation of Enol Ethers. Chemistry Letters. 16: 223-226. PMID 31595102 DOI: 10.1246/Cl.1987.223  0.584
1987 Corey EJ, Ghosh AK. Mn(III)-PROMOTED ANNULATION OF ENOL ETHERS AND ESTERS TO FUSED OR SPIRO 2-CYCLOPENTENONES. Tetrahedron Letters. 28: 175-178. PMID 31595094 DOI: 10.1016/S0040-4039(00)95679-X  0.596
1985 Kozikowski AP, Ghosh AK. Methods for Pyranoannulation: An Approach to a New Class of Polyethers. The Journal of Organic Chemistry. 50: 3017-3019. PMID 31285634 DOI: 10.1002/Chin.198552215  0.613
1984 Kozikowski AP, Ghosh AK. Diastereofacial Selection in Nitrile Oxide Cycloaddition Reactions. The Anti-Directing Effect of an Allylic Oxygen and Some New Results on the Ring Metalation of Isoxazolines. A Synthesis of (±)-Blastmycinone. The Journal of Organic Chemistry. 49: 2762-2772. PMID 31527928 DOI: 10.1002/Chin.198451113  0.657
1983 Kozikowski AP, Ghosh AK. The Isoxazoline Route to α-Methylene Lactones. Tetrahedron Letters. 24: 2623-2626. PMID 31595093 DOI: 10.1016/S0040-4039(00)87961-7  0.603
1982 Kozikowski AP, Ghosh AK. Diastereoselection in Intermolecular Nitrile Oxide Cycloaddition (NOC) Reactions: Confirmation of the "Anti-Periplanar Effect" through a Simple Synthesis of 2-Deoxy-d-ribose. Journal of the American Chemical Society. 104: 5788-5789. PMID 31156251 DOI: 10.1002/Chin.198304355  0.63
1979 VENKATESWARAN RV, GHOSH A, SARKAR A. ChemInform Abstract: DECARBOXYLATION OF ALKYLIDENE CYANO-ESTERS Chemischer Informationsdienst. 10. DOI: 10.1002/Chin.197920160  0.311
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