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Hui-Kuan Lin, Ph.D. - Publications

Affiliations: 
2002 University of Rochester, Rochester, NY 
Area:
Pathology, Oncology, Molecular Biology
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58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Hu L, Liu M, Tang B, Li Q, Pan BS, Xu C, Lin HK. Posttranslational regulation of liver kinase B1 (LKB1) in human cancer. The Journal of Biological Chemistry. 104570. PMID 36870679 DOI: 10.1016/j.jbc.2023.104570  0.301
2023 Tsai PJ, Lai YH, Manne RK, Tsai YS, Sarbassov D, Lin HK. Correction: Akt: a key transducer in cancer. Journal of Biomedical Science. 30: 7. PMID 36698128 DOI: 10.1186/s12929-023-00900-y  0.318
2022 Tsai PJ, Lai YH, Manne RK, Tsai YS, Sarbassov D, Lin HK. Akt: a key transducer in cancer. Journal of Biomedical Science. 29: 76. PMID 36180910 DOI: 10.1186/s12929-022-00860-9  0.325
2020 Hu YC, Yeh S, Yeh SD, Sampson ER, Huang J, Li P, Hsu CL, Ting HJ, Lin HK, Wang L, Kim E, Ni J, Chang C. Correction: Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. The Journal of Biological Chemistry. 295: 17382. PMID 33453984 DOI: 10.1074/jbc.AAC120.016763  0.827
2020 Cai Z, Peng D, Lin HK. AMPK maintains TCA cycle through sequential phosphorylation of PDHA to promote tumor metastasis. Cell Stress. 4: 273-277. PMID 33336150 DOI: 10.15698/cst2020.12.238  0.308
2020 Hu YC, Yeh S, Yeh SD, Sampson ER, Huang J, Li P, Hsu CL, Ting HJ, Lin HK, Wang L, Kim E, Ni J, Chang C. Correction: Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. The Journal of Biological Chemistry. 295: 17382. PMID 33310747 DOI: 10.1074/jbc.AAC120.016763  0.827
2020 Cai Z, Li CF, Han F, Liu C, Zhang A, Hsu CC, Peng D, Zhang X, Jin G, Rezaeian AH, Wang G, Zhang W, Pan BS, Wang CY, Wang YH, ... ... Lin HK, et al. Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis. Molecular Cell. PMID 33022274 DOI: 10.1016/j.molcel.2020.09.018  0.323
2020 Snider AJ, Seeds MC, Johnstone L, Snider JM, Hallmark B, Dutta R, Moraga Franco C, Parks JS, Bensen JT, Broeckling CD, Mohler JL, Smith GJ, Fontham ETH, Lin HK, Bresette W, et al. Identification of Plasma Glycosphingolipids as Potential Biomarkers for Prostate Cancer (PCa) Status. Biomolecules. 10. PMID 33007922 DOI: 10.3390/biom10101393  0.464
2020 Cai Z, Moten A, Peng D, Hsu CC, Pan BS, Kumar Manne R, Li HY, Lin HK. The Skp2 Pathway: A Critical Target for Cancer Therapy. Seminars in Cancer Biology. PMID 32014608 DOI: 10.1016/J.Semcancer.2020.01.013  0.409
2019 Ji Z, Zhao W, Lin HK, Zhou X. Systematically understanding the immunity leading to CRPC progression. Plos Computational Biology. 15: e1007344. PMID 31504033 DOI: 10.1371/Journal.Pcbi.1007344  0.448
2019 Wu X, Park M, Sarbassova DA, Ying H, Lee MG, Bhattacharya R, Ellis L, Peterson CB, Hung MC, Lin HK, Bersimbaev RI, Song MS, Sarbassov DD. A Chirality-Dependent Action of Vitamin C in Suppressing KRAS Mutant Tumor Growth by the Oxidative Combination: Rationale for Cancer Therapeutics. International Journal of Cancer. PMID 31472018 DOI: 10.1002/Ijc.32658  0.318
2019 Li Y, Huang JH, Wang JL, Song GT, Tang D, Yao F, Lin HK, Yan W, Li HY, Xu ZG, Chen ZZ. Diversity-Oriented Synthesis of Imidazo-Dipyridines with Anticancer Activity via Groebke-Blackburn-Bienaymé and TBAB-Mediated Cascade Reaction in One Pot. The Journal of Organic Chemistry. PMID 31357859 DOI: 10.1021/acs.joc.9b01385  0.321
2018 Han F, Li CF, Cai Z, Zhang X, Jin G, Zhang WN, Xu C, Wang CY, Morrow J, Zhang S, Xu D, Wang G, Lin HK. The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance. Nature Communications. 9: 4728. PMID 30413706 DOI: 10.1038/s41467-018-07188-9  0.301
2018 Liu C, Cai Z, Jin G, Peng D, Pan BS, Zhang X, Han F, Xu X, Lin HK. Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance. Cell Discovery. 4: 54. PMID 30302273 DOI: 10.1038/S41421-018-0054-X  0.307
2018 Lee SW, Lin HK. A new mechanism for LKB1 activation. Molecular & Cellular Oncology. 5: e1035691. PMID 30250874 DOI: 10.1080/23723556.2015.1035691  0.366
2017 Ruan D, He J, Li CF, Lee HJ, Liu J, Lin HK, Chan CH. Skp2 deficiency restricts the progression and stem cell features of castration-resistant prostate cancer by destabilizing Twist. Oncogene. PMID 28346424 DOI: 10.1038/onc.2017.64  0.49
2016 Zhang X, Lin HK. NBR2-GLUT1 axis regulates cancer cell sensitivity to biguanides. Cell Cycle (Georgetown, Tex.). 0. PMID 27929708 DOI: 10.1080/15384101.2016.1263498  0.44
2016 Rezaeian AH, Li CF, Wu CY, Zhang X, Delacerda J, You MJ, Han F, Cai Z, Jeong YS, Jin G, Phan L, Chou PC, Lee MH, Hung MC, Sarbassov D, ... Lin HK, et al. A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis. Nature Cell Biology. PMID 27918549 DOI: 10.1038/ncb3445  0.336
2016 Bawa-Khalfe T, Yang FM, Ritho J, Lin HK, Cheng J, Yeh ET. SENP1 regulates PTEN stability to dictate prostate cancer development. Oncotarget. PMID 27852060 DOI: 10.18632/Oncotarget.13283  0.63
2016 Sharma S, Xing F, Liu Y, Wu K, Said N, Pochampally R, Shiozawa Y, Lin HK, Balaji KC, Watabe K. Secreted Protein Acidic and Rich in Cysteine (SPARC) Mediates Metastatic Dormancy of Prostate Cancer in the Bone. The Journal of Biological Chemistry. PMID 27422817 DOI: 10.1074/Jbc.M116.737379  0.517
2016 Li N, Dhar SS, Chen TY, Kan PY, Wei Y, Kim JH, Chan CH, Lin HK, Hung MC, Lee MG. JARID1D is a suppressor and prognostic marker of prostate cancer invasion and metastasis. Cancer Research. PMID 26747897 DOI: 10.1158/0008-5472.CAN-15-0906  0.51
2016 Chen YA, Lee K, Lin Y, Li C, Yen C, Lin H, Chen Y. Abstract 4418: Identification and characterization of patient-derived PREX2 mutation in HCC Cancer Research. 76: 4418-4418. DOI: 10.1158/1538-7445.Am2016-4418  0.326
2015 Tsai YT, Chuang MJ, Tang SH, Wu ST, Chen YC, Sun GH, Hsiao PW, Huang SM, Lee HJ, Yu CP, Ho JY, Lin HK, Chen MR, Lin CC, Chang SY, et al. Novel Cancer Therapeutics with Allosteric Modulation of The Mitochondrial C-Raf/DAPK Complex by Raf Inhibitor Combination Therapy. Cancer Research. PMID 26100670 DOI: 10.1158/0008-5472.Can-14-3264  0.353
2014 Chan CH, Jo U, Kohrman A, Rezaeian AH, Chou PC, Logothetis C, Lin HK. Posttranslational regulation of Akt in human cancer. Cell & Bioscience. 4: 59. PMID 25309720 DOI: 10.1186/2045-3701-4-59  0.452
2014 Wagner KW, Alam H, Dhar SS, Giri U, Li N, Wei Y, Cascone T, Giri D, Kim J, Ye Y, Multani A, Chan C, Erez B, Saigal B, Lin H, et al. Abstract 5146: The histone demethylase KDM2A is a new promoter of tumorigenesis, drug target and negative prognostic biomarker for non-small cell lung cancer Cancer Research. 74: 5146-5146. DOI: 10.1158/1538-7445.Am2014-5146  0.38
2013 Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 154: 556-68. PMID 23911321 DOI: 10.1016/j.cell.2013.06.048  0.361
2013 Yang WL, Jin G, Li CF, Jeong YS, Moten A, Xu D, Feng Z, Chen W, Cai Z, Darnay B, Gu W, Lin HK. Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling. Science Signaling. 6: ra3. PMID 23300340 DOI: 10.1126/scisignal.2003197  0.32
2013 Wu J, Lee SW, Zhang X, Han F, Kwan SY, Yuan X, Yang WL, Jeong YS, Rezaeian AH, Gao Y, Zeng YX, Lin HK. Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex. Oncogene. 32: 78-85. PMID 22310285 DOI: 10.1038/Onc.2012.26  0.34
2012 Wei W, Lin HK. The key role of ubiquitination and sumoylation in signaling and cancer: a research topic. Frontiers in Oncology. 2: 187. PMID 23227454 DOI: 10.3389/Fonc.2012.00187  0.405
2012 Wang G, Gao Y, Li L, Jin G, Cai Z, Chao JI, Lin HK. K63-linked ubiquitination in kinase activation and cancer. Frontiers in Oncology. 2: 5. PMID 22649774 DOI: 10.3389/Fonc.2012.00005  0.344
2012 Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, ... ... Lin HK, et al. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell. 149: 1098-111. PMID 22632973 DOI: 10.1016/J.Cell.2012.02.065  0.302
2012 Wang G, Chan CH, Gao Y, Lin HK. Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis. Chinese Journal of Cancer. 31: 169-77. PMID 22200179 DOI: 10.5732/Cjc.011.10319  0.315
2011 Samaniego F, Berkova Z, Wise JF, Kerros C, Hawke DH, Karp JE, Lin H, Molldrem JJ, Tao R. PML and PMLRARα Interact with Fas to Regulate Fas-Mediated Apoptosis In Vivo Blood. 118: 2451-2451. DOI: 10.1182/Blood.V118.21.2451.2451  0.395
2010 Yang W, Zhang X, Lin H. Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development. Oncogene. 29: 4493-4503. PMID 20531303 DOI: 10.1038/Onc.2010.190  0.426
2010 Chan CH, Lee SW, Wang J, Lin HK. Regulation of Skp2 expression and activity and its role in cancer progression. Thescientificworldjournal. 10: 1001-15. PMID 20526532 DOI: 10.1100/tsw.2010.89  0.364
2010 Yang WL, Wu CY, Wu J, Lin HK. Regulation of Akt signaling activation by ubiquitination. Cell Cycle (Georgetown, Tex.). 9: 487-97. PMID 20081374  0.327
2009 Chen Z, Carracedo A, Lin HK, Koutcher JA, Behrendt N, Egia A, Alimonti A, Carver BS, Gerald W, Teruya-Feldstein J, Loda M, Pandolfi PP. Differential p53-independent outcomes of p19(Arf) loss in oncogenesis. Science Signaling. 2: ra44. PMID 19690330 DOI: 10.1126/Scisignal.2000053  0.407
2008 Chang CC, Yeh MS, Lin HK, Cheng W. The effect of Vibrio alginolyticus infection on caspase-3 expression and activity in white shrimp Litopenaeus vannamei. Fish & Shellfish Immunology. 25: 672-8. PMID 18840531 DOI: 10.1016/j.fsi.2008.09.004  0.378
2007 Carver BS, Lin H, Chen Z, Trotman L, Scardino PT, Pandolfi PP. 663: XPD (ERCC-2) and Prostate Cancer: Susceptibility Depends on the Degree of DNA Damage and Transcriptional Interference Journal of Urology. 177: 222-223. DOI: 10.1016/S0022-5347(18)30903-0  0.543
2005 Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M, Koutcher JA, Scher HI, Ludwig T, Gerald W, Cordon-Cardo C, Pandolfi PP. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature. 436: 725-30. PMID 16079851 DOI: 10.1038/Nature03918  0.535
2004 Lin HK, Hu YC, Lee DK, Chang C. Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells. Molecular Endocrinology (Baltimore, Md.). 18: 2409-23. PMID 15205473 DOI: 10.1210/Me.2004-0117  0.834
2004 Wang L, Lin HK, Hu YC, Xie S, Yang L, Chang C. Suppression of androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells. The Journal of Biological Chemistry. 279: 32444-52. PMID 15178691 DOI: 10.1074/Jbc.M313963200  0.82
2004 Kang HY, Cho CL, Huang KL, Wang JC, Hu YC, Lin HK, Chang C, Huang KE. Nongenomic androgen activation of phosphatidylinositol 3-kinase/Akt signaling pathway in MC3T3-E1 osteoblasts. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 19: 1181-90. PMID 15177002 DOI: 10.1359/Jbmr.040306  0.759
2004 Hu YC, Yeh S, Yeh SD, Sampson ER, Huang J, Li P, Hsu CL, Ting HJ, Lin HK, Wang L, Kim E, Ni J, Chang C. Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. The Journal of Biological Chemistry. 279: 33438-46. PMID 15166229 DOI: 10.1074/Jbc.M401781200  0.842
2004 Xie S, Lin HK, Ni J, Yang L, Wang L, di Sant'Agnese PA, Chang C. Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells. The Prostate. 60: 61-7. PMID 15129430 DOI: 10.1002/Pros.20048  0.826
2004 Lin H, Bergmann S, Pandolfi PP. Cytoplasmic PML Function in TGF-β Signaling. Blood. 104: 481-481. DOI: 10.1182/Blood.V104.11.481.481  0.308
2003 Altuwaijri S, Lin HK, Chuang KH, Lin WJ, Yeh S, Hanchett LA, Rahman MM, Kang HY, Tsai MY, Zhang Y, Yang L, Chang C. Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells. Cancer Research. 63: 7106-12. PMID 14612503  0.801
2003 Lin HK, Hu YC, Yang L, Altuwaijri S, Chen YT, Kang HY, Chang C. Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers. The Journal of Biological Chemistry. 278: 50902-7. PMID 14555644 DOI: 10.1074/Jbc.M300676200  0.855
2003 Yang L, Wang L, Lin HK, Kan PY, Xie S, Tsai MY, Wang PH, Chen YT, Chang C. Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells. Biochemical and Biophysical Research Communications. 305: 462-9. PMID 12763015 DOI: 10.1016/S0006-291X(03)00792-7  0.807
2003 Yang L, Lin HK, Altuwaijri S, Xie S, Wang L, Chang C. APPL suppresses androgen receptor transactivation via potentiating Akt activity. The Journal of Biological Chemistry. 278: 16820-7. PMID 12621049 DOI: 10.1074/Jbc.M213163200  0.803
2002 Lin HK, Wang L, Hu YC, Altuwaijri S, Chang C. Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. The Embo Journal. 21: 4037-48. PMID 12145204 DOI: 10.1093/Emboj/Cdf406  0.823
2002 Lin HK, Altuwaijri S, Lin WJ, Kan PY, Collins LL, Chang C. Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells. The Journal of Biological Chemistry. 277: 36570-6. PMID 12119296 DOI: 10.1074/Jbc.M204751200  0.861
2001 Lin HK, Yeh S, Kang HY, Chang C. Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proceedings of the National Academy of Sciences of the United States of America. 98: 7200-5. PMID 11404460 DOI: 10.1073/Pnas.121173298  0.663
2001 Kang HY, Lin HK, Hu YC, Yeh S, Huang KE, Chang C. From transforming growth factor-beta signaling to androgen action: identification of Smad3 as an androgen receptor coregulator in prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 3018-23. PMID 11248024 DOI: 10.1073/Pnas.061305498  0.785
2000 Yeh S, Hu YC, Rahman M, Lin HK, Hsu CL, Ting HJ, Kang HY, Chang C. Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 11256-61. PMID 11016951 DOI: 10.1073/Pnas.190353897  0.826
1999 Yeh S, Kang HY, Miyamoto H, Nishimura K, Chang HC, Ting HJ, Rahman M, Lin HK, Fujimoto N, Hu YC, Mizokami A, Huang KE, Chang C. Differential induction of androgen receptor transactivation by different androgen receptor coactivators in human prostate cancer DU145 cells. Endocrine. 11: 195-202. PMID 10709768 DOI: 10.1385/Endo:11:2:195  0.841
1999 Yeh S, Chang HC, Miyamoto H, Takatera H, Rahman M, Kang HY, Thin TH, Lin HK, Chang C. Differential induction of the androgen receptor transcriptional activity by selective androgen receptor coactivators. The Keio Journal of Medicine. 48: 87-92. PMID 10405524 DOI: 10.2302/Kjm.48.87  0.806
1999 Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C. From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 96: 5458-63. PMID 10318905 DOI: 10.1073/Pnas.96.10.5458  0.716
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