| Year |
Citation |
Score |
| 2024 |
Amitzi L, Cozma E, Tong AHY, Chan K, Ross C, O'Neil N, Moffat J, Stirling P, Hieter P. Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency. G3 (Bethesda, Md.). PMID 38478595 DOI: 10.1093/g3journal/jkae052 |
0.358 |
|
| 2023 |
Lin P, Lourenco C, Cruickshank J, Palomero L, van Leeuwen JE, Tong AHY, Chan K, El Ghamrasni S, Pujana MA, Cescon DW, Moffat J, Penn LZ. Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality. Cancer Research. OF1-OF15. PMID 37987734 DOI: 10.1158/0008-5472.CAN-22-2948 |
0.309 |
|
| 2023 |
Varland S, Silva RD, Kjosås I, Faustino A, Bogaert A, Billmann M, Boukhatmi H, Kellen B, Costanzo M, Drazic A, Osberg C, Chan K, Zhang X, Tong AHY, Andreazza S, ... ... Moffat J, et al. N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity. Nature Communications. 14: 6774. PMID 37891180 DOI: 10.1038/s41467-023-42342-y |
0.694 |
|
| 2023 |
Billmann M, Ward HN, Aregger M, Costanzo M, Andrews BJ, Boone C, Moffat J, Myers CL. Reproducibility metrics for context-specific CRISPR screens. Cell Systems. 14: 418-422.e2. PMID 37201508 DOI: 10.1016/j.cels.2023.04.003 |
0.714 |
|
| 2022 |
Bock C, Datlinger P, Chardon F, Coelho MA, Dong MB, Lawson KA, Lu T, Maroc L, Norman TM, Song B, Stanley G, Chen S, Garnett M, Li W, Moffat J, et al. High-content CRISPR screening. Nature Reviews. Methods Primers. 2. PMID 37214176 DOI: 10.1038/s43586-022-00098-7 |
0.348 |
|
| 2022 |
Chan K, Farias AG, Lee H, Guvenc F, Mero P, Brown KR, Ward H, Billmann M, Aulakh K, Astori A, Haider S, Marcon E, Braunschweig U, Pu S, Habsid A, ... ... Moffat J, et al. Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors. Heliyon. e12744. PMID 36597481 DOI: 10.1016/j.heliyon.2022.e12744 |
0.301 |
|
| 2022 |
Masud SN, Chandrashekhar M, Aregger M, Tan G, Zhang X, Mero P, Pirman DA, Zaslaver O, Smolen GA, Lin ZY, Wong CJ, Boone C, Gingras AC, Montenegro-Burke JR, Moffat J. Author Correction: Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux. Nature Chemical Biology. PMID 36002506 DOI: 10.1038/s41589-022-01146-9 |
0.767 |
|
| 2022 |
Masud SN, Chandrashekhar M, Aregger M, Tan G, Zhang X, Mero P, Pirman DA, Zaslaver O, Smolen GA, Lin ZY, Wong CJ, Boone C, Gingras AC, Montenegro-Burke RJ, Moffat J. Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux. Nature Chemical Biology. PMID 35970996 DOI: 10.1038/s41589-022-01109-0 |
0.785 |
|
| 2022 |
Mair B, Aregger M, Tong AHY, Chan KSK, Moffat J. A Method to Map Gene Essentiality of Human Pluripotent Stem Cells by Genome-Scale CRISPR Screens with Inducible Cas9. Methods in Molecular Biology (Clifton, N.J.). 2377: 1-27. PMID 34709608 DOI: 10.1007/978-1-0716-1720-5_1 |
0.352 |
|
| 2021 |
Rahman M, Billmann M, Costanzo M, Aregger M, Tong AHY, Chan K, Ward HN, Brown KR, Andrews BJ, Boone C, Moffat J, Myers CL. A method for benchmarking genetic screens reveals a predominant mitochondrial bias. Molecular Systems Biology. 17: e10013. PMID 34018332 DOI: 10.15252/msb.202010013 |
0.732 |
|
| 2020 |
Lawson KA, Sousa CM, Zhang X, Kim E, Akthar R, Caumanns JJ, Yao Y, Mikolajewicz N, Ross C, Brown KR, Zid AA, Fan ZP, Hui S, Krall JA, Simons DM, ... ... Moffat J, et al. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Nature. PMID 32968282 DOI: 10.1038/s41586-020-2746-2 |
0.342 |
|
| 2020 |
Aregger M, Lawson KA, Billmann M, Costanzo M, Tong AHY, Chan K, Rahman M, Brown KR, Ross C, Usaj M, Nedyalkova L, Sizova O, Habsid A, Pawling J, Lin ZY, ... ... Moffat J, et al. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. Nature Metabolism. 2: 499-513. PMID 32694731 DOI: 10.1038/s42255-020-0211-z |
0.706 |
|
| 2020 |
Aubry A, Pearson JD, Huang K, Livne-Bar I, Ahmad M, Jagadeesan M, Khetan V, Ketela T, Brown KR, Yu T, Lu S, Wrana JL, Moffat J, Bremner R. Functional genomics identifies new synergistic therapies for retinoblastoma. Oncogene. PMID 32572160 DOI: 10.1038/S41388-020-1372-7 |
0.397 |
|
| 2020 |
Vora P, Venugopal C, Salim SK, Tatari N, Bakhshinyan D, Singh M, Seyfrid M, Upreti D, Rentas S, Wong N, Williams R, Qazi MA, Chokshi C, Ding A, Subapanditha M, ... ... Moffat J, et al. The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma. Cell Stem Cell. PMID 32464096 DOI: 10.1016/J.Stem.2020.04.008 |
0.327 |
|
| 2020 |
Gonatopoulos-Pournatzis T, Aregger M, Brown KR, Farhangmehr S, Braunschweig U, Ward HN, Ha KCH, Weiss A, Billmann M, Durbic T, Myers CL, Blencowe BJ, Moffat J. Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9-Cas12a platform. Nature Biotechnology. PMID 32249828 DOI: 10.1038/S41587-020-0437-Z |
0.453 |
|
| 2020 |
Liu Y, Kim J, Philip R, Sridhar V, Chandrashekhar M, Moffat J, van Breugel M, Pelletier L. Direct interaction between CEP85 and STIL mediates PLk4-driven directed cell migration. Journal of Cell Science. PMID 32107292 DOI: 10.1242/Jcs.238352 |
0.407 |
|
| 2020 |
Mis M, O'Brien S, Steinhart Z, Lin S, Hart T, Moffat J, Angers S. IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers. The Journal of Cell Biology. 219. PMID 31881079 DOI: 10.1083/Jcb.201903017 |
0.444 |
|
| 2020 |
Lawson K, Zhang X, Sousa C, Akthar R, Fan Z, Kim E, Colic M, Tong A, Chan K, Huang Q, Wang X, Brown K, Aregger M, Finelli A, Ailles L, ... ... Moffat J, et al. Abstract B60: Functional genomic landscape of T-cell mediated cytotoxicity Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm18-B60 |
0.493 |
|
| 2020 |
Moffat J, Zhang X, Lawson K, Banerjee S, Wang X, Adams J, Pan J, Ailles L, Finelli A, Sidhu S. Abstract B49: Development and characterization of a novel CA9 targeting dual-antibody T-cell engager for renal cell carcinoma Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm18-B49 |
0.327 |
|
| 2019 |
Manoranjan B, Chokshi C, Venugopal C, Subapanditha M, Savage N, Tatari N, Provias JP, Murty NK, Moffat J, Doble BW, Singh SK. A CD133-AKT-Wnt signaling axis drives glioblastoma brain tumor-initiating cells. Oncogene. PMID 31695152 DOI: 10.1038/S41388-019-1086-X |
0.328 |
|
| 2019 |
Cina DP, Ketela T, Brown KR, Chandrashekhar M, Mero P, Li C, Onay T, Fu Y, Han Z, Saleem MA, Moffat J, Quaggin SE. Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion. American Journal of Physiology. Renal Physiology. PMID 31566424 DOI: 10.1152/Ajprenal.00195.2019 |
0.424 |
|
| 2019 |
Mair B, Aldridge PM, Atwal RS, Philpott D, Zhang M, Masud SN, Labib M, Tong AHY, Sargent EH, Angers S, Moffat J, Kelley SO. High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting. Nature Biomedical Engineering. PMID 31548591 DOI: 10.1038/S41551-019-0454-8 |
0.805 |
|
| 2019 |
Chan K, Tong AHY, Brown KR, Mero P, Moffat J. Pooled CRISPR-Based Genetic Screens in Mammalian Cells. Journal of Visualized Experiments : Jove. PMID 31545321 DOI: 10.3791/59780 |
0.389 |
|
| 2019 |
Brown KR, Mair B, Soste M, Moffat J. CRISPR screens are feasible in TP53 wild-type cells. Molecular Systems Biology. 15: e8679. PMID 31464370 DOI: 10.15252/Msb.20188679 |
0.361 |
|
| 2019 |
Tao Y, Mis M, Blazer L, Ustav M, Steinhart Z, Chidiac R, Kubarakos E, O'Brien S, Wang X, Jarvik N, Patel N, Adams J, Moffat J, Angers S, Sidhu SS. Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice. Elife. 8. PMID 31452509 DOI: 10.7554/Elife.46134 |
0.356 |
|
| 2019 |
Colic M, Wang G, Zimmermann M, Mascall K, McLaughlin M, Bertolet L, Lenoir WF, Moffat J, Angers S, Durocher D, Hart T. Identifying chemogenetic interactions from CRISPR screens with drugZ. Genome Medicine. 11: 52. PMID 31439014 DOI: 10.1186/S13073-019-0665-3 |
0.406 |
|
| 2019 |
Vora P, Seyfrid M, Venugopal C, Qazi MA, Salim S, Isserlin R, Subapanditha M, O'Farrell E, Mahendram S, Singh M, Bakhshinyan D, Chokshi C, McFarlane N, Dvorkin-Gheva A, Brown KR, ... ... Moffat J, et al. Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells. Journal of Neuro-Oncology. PMID 31115870 DOI: 10.1007/S11060-019-03192-1 |
0.35 |
|
| 2019 |
Mair B, Moffat J, Boone C, Andrews BJ. Genetic interaction networks in cancer cells. Current Opinion in Genetics & Development. 54: 64-72. PMID 30974317 DOI: 10.1016/J.Gde.2019.03.002 |
0.589 |
|
| 2019 |
Mair B, Tomic J, Masud SN, Tonge P, Weiss A, Usaj M, Tong AHY, Kwan JJ, Brown KR, Titus E, Atkins M, Chan KSK, Munsie L, Habsid A, Han H, ... ... Moffat J, et al. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies. Cell Reports. 27: 599-615.e12. PMID 30970261 DOI: 10.1016/J.Celrep.2019.02.041 |
0.807 |
|
| 2019 |
Costanzo M, Kuzmin E, van Leeuwen J, Mair B, Moffat J, Boone C, Andrews B. Global Genetic Networks and the Genotype-to-Phenotype Relationship. Cell. 177: 85-100. PMID 30901552 DOI: 10.1016/J.Cell.2019.01.033 |
0.698 |
|
| 2019 |
Raman S, Beilschmidt M, To M, Lin K, Lui F, Jmeian Y, Ng M, Fernandez M, Fu Y, Mascall K, Duque A, Wang X, Pan G, Angers S, Moffat J, et al. Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proceedings of the National Academy of Sciences of the United States of America. PMID 30894493 DOI: 10.1073/Pnas.1817246116 |
0.308 |
|
| 2019 |
Pascoe N, Seetharaman A, Teyra J, Manczyk N, Satori MA, Tjandra D, Makhnevych T, Schwerdtfeger C, Brasher BB, Moffat J, Costanzo M, Boone C, Sicheri F, Sidhu S. Yeast Two-Hybrid Analysis for Ubiquitin-Variant Inhibitors of Human Deubiquitinases. Journal of Molecular Biology. PMID 30763569 DOI: 10.1016/J.Jmb.2019.02.007 |
0.653 |
|
| 2019 |
Nixon AML, Duque A, Yelle N, McLaughlin M, Davoudi S, Pedley NM, Haynes J, Brown KR, Pan J, Hart T, Gilbert PM, Singh SK, O'Brien CA, Sidhu SS, Moffat J. A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations. Scientific Reports. 9: 842. PMID 30696911 DOI: 10.1038/S41598-018-37462-1 |
0.387 |
|
| 2019 |
Aregger M, Chandrashekhar M, Tong AHY, Chan K, Moffat J. Pooled Lentiviral CRISPR-Cas9 Screens for Functional Genomics in Mammalian Cells. Methods in Molecular Biology (Clifton, N.J.). 1869: 169-188. PMID 30324523 DOI: 10.1007/978-1-4939-8805-1_15 |
0.494 |
|
| 2019 |
Hu AX, Adams JJ, Vora P, Qazi M, Singh SK, Moffat J, Sidhu SS. EPH Profiling of BTIC Populations in Glioblastoma Multiforme Using CyTOF. Methods in Molecular Biology (Clifton, N.J.). 1869: 155-168. PMID 30324522 DOI: 10.1007/978-1-4939-8805-1_14 |
0.385 |
|
| 2019 |
Jain P, Sayad A, Mollen E, Xie M, Brown K, Moffat J, Hedley D, Boutros P, Wouters B, Koritzinsky M. Abstract 883: PRDX4 as a novel target for pancreatic cancer Cancer Research. 79: 883-883. DOI: 10.1158/1538-7445.Am2019-883 |
0.414 |
|
| 2019 |
Vora P, Venugopal C, Chokshi C, Qazi M, Tatari N, Brown K, Yelle N, Adams J, Tieu D, Seyfrid M, Singh M, Savage N, Subapanditha M, Bakhshinyan D, Kuhlmann L, ... ... Moffat J, et al. Abstract 570: A glioblastoma translational pipeline: discovery of novel tumor antigens that drive GBM recurrence Cancer Research. 79: 570-570. DOI: 10.1158/1538-7445.Am2019-570 |
0.377 |
|
| 2018 |
Turowec JP, Lau EWT, Wang X, Brown KR, Fellouse FA, Jawanda KK, Pan J, Moffat J, Sidhu S. Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response. The Journal of Biological Chemistry. PMID 30523157 DOI: 10.1074/Jbc.Ra118.004420 |
0.319 |
|
| 2018 |
Jangra RK, Herbert AS, Li R, Jae LT, Kleinfelter LM, Slough MM, Barker SL, Guardado-Calvo P, Román-Sosa G, Dieterle ME, Kuehne AI, Muena NA, Wirchnianski AS, Nyakatura EK, Fels JM, ... ... Moffat J, et al. Protocadherin-1 is essential for cell entry by New World hantaviruses. Nature. 563: 559-563. PMID 30464266 DOI: 10.1038/S41586-018-0702-1 |
0.309 |
|
| 2018 |
Gonatopoulos-Pournatzis T, Wu M, Braunschweig U, Roth J, Han H, Best AJ, Raj B, Aregger M, O'Hanlon D, Ellis JD, Calarco JA, Moffat J, Gingras AC, Blencowe BJ. Genome-wide CRISPR-Cas9 Interrogation of Splicing Networks Reveals a Mechanism for Recognition of Autism-Misregulated Neuronal Microexons. Molecular Cell. 72: 510-524.e12. PMID 30388412 DOI: 10.1016/J.Molcel.2018.10.008 |
0.359 |
|
| 2018 |
Pavlovic Z, Adams JJ, Blazer LL, Gakhal AK, Jarvik N, Steinhart Z, Robitaille M, Mascall K, Pan J, Angers S, Moffat J, Sidhu SS. A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties. Mabs. PMID 30183492 DOI: 10.1080/19420862.2018.1515565 |
0.307 |
|
| 2018 |
Zimmermann M, Murina O, Reijns MAM, Agathanggelou A, Challis R, Tarnauskaitė Ž, Muir M, Fluteau A, Aregger M, McEwan A, Yuan W, Clarke M, Lambros MB, Paneesha S, Moss P, ... ... Moffat J, et al. CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. Nature. PMID 29973717 DOI: 10.1038/S41586-018-0291-Z |
0.403 |
|
| 2018 |
Qazi MA, Vora P, Venugopal C, Adams J, Singh M, Hu AX, Gorelik M, Subapanditha MK, Savage N, Yang J, Chokshi C, London M, Gont A, Bobrowski D, Grinshtein N, ... ... Moffat J, et al. Co-targeting ephrin receptor tyrosine kinases A2 and A3 in cancer stem cells reduces growth of recurrent glioblastoma. Cancer Research. PMID 29945963 DOI: 10.1158/0008-5472.Can-18-0267 |
0.364 |
|
| 2018 |
Velimezi G, Robinson-Garcia L, Muñoz-Martínez F, Wiegant WW, Ferreira da Silva J, Owusu M, Moder M, Wiedner M, Rosenthal SB, Fisch KM, Moffat J, Menche J, van Attikum H, Jackson SP, Loizou JI. Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48. Nature Communications. 9: 2280. PMID 29891926 DOI: 10.1038/S41467-018-04649-Z |
0.35 |
|
| 2018 |
Tanaka M, Fine JH, Kirkham CL, Aguilar OA, Belcheva A, Martin A, Ketela T, Moffat J, Allan DS, Carlyle JR. The inhibitory NKR-P1B:Clr-b recognition axis facilitates detection of oncogenic transformation and cancer immunosurveillance. Cancer Research. PMID 29691253 DOI: 10.1158/0008-5472.Can-17-1688 |
0.33 |
|
| 2018 |
Pollock SB, Hu A, Mou Y, Martinko AJ, Julien O, Hornsby M, Ploder L, Adams JJ, Geng H, Müschen M, Sidhu SS, Moffat J, Wells JA. Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies. Proceedings of the National Academy of Sciences of the United States of America. PMID 29476010 DOI: 10.1073/Pnas.1721899115 |
0.387 |
|
| 2018 |
Chokshi C, Tieu D, Brown K, Venugopal C, Vora P, Chan K, Tong A, Qazi M, Singh M, Savage N, Habsid A, Moffat J, Singh S. Abstract 390: Genome-wide CRISPR screens in brain tumor initiating cells (BTICs) identify potent sensitizers and resistors of conventional chemoradiotherapy Cancer Research. 78: 390-390. DOI: 10.1158/1538-7445.Am2018-390 |
0.364 |
|
| 2018 |
Vora P, Adams J, Singh M, Venugopal C, Tatari N, Chokshi C, Qazi M, Salim S, Mahendram S, Bakhshinyan D, London M, Savage N, Subapanditha M, McFarlane N, Pan J, ... ... Moffat J, et al. Abstract 1763: BiTEs vs CAR-Ts: Preclinical targeting of CD133+ brain tumor initiating cells using immunotherapy-based treatment strategies Cancer Research. 78: 1763-1763. DOI: 10.1158/1538-7445.Am2018-1763 |
0.329 |
|
| 2017 |
Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, ... Moffat J, et al. Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nature Medicine. 23: 1384. PMID 29117169 DOI: 10.1038/Nm1117-1384D |
0.342 |
|
| 2017 |
Rancati G, Moffat J, Typas A, Pavelka N. Emerging and evolving concepts in gene essentiality. Nature Reviews. Genetics. PMID 29033457 DOI: 10.1038/Nrg.2017.74 |
0.395 |
|
| 2017 |
Singh M, Venugopal C, Tokar T, Brown KR, McFarlane N, Bakhshinyan D, Vijayakumar T, Manoranjan B, Mahendram S, Vora P, Qazi M, Dhillon M, Tong A, Durrer K, Murty N, ... ... Moffat J, et al. RNAi screen identifies essential regulators of human brain metastasis-initiating cells. Acta Neuropathologica. PMID 28766011 DOI: 10.1007/S00401-017-1757-Z |
0.384 |
|
| 2017 |
Hart T, Tong AHY, Chan K, Van Leeuwen J, Seetharaman A, Aregger M, Chandrashekhar M, Hustedt N, Seth S, Noonan A, Habsid A, Sizova O, Nedyalkova L, Climie R, Tworzyanski L, ... ... Moffat J, et al. Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens. G3 (Bethesda, Md.). PMID 28655737 DOI: 10.1534/G3.117.041277 |
0.792 |
|
| 2017 |
Zhang W, Sartori MA, Makhnevych T, Federowicz KE, Dong X, Liu L, Nim S, Dong A, Yang J, Li Y, Haddad D, Ernst A, Heerding D, Tong Y, Moffat J, et al. Generation and validation of intracellular ubiquitin variant inhibitors for USP7 and USP10. Journal of Molecular Biology. PMID 28587923 DOI: 10.1016/J.Jmb.2017.05.025 |
0.399 |
|
| 2017 |
Qazi MA, Vora P, Venugopal C, Sidhu SS, Moffat J, Swanton C, Singh SK. Intratumoral Heterogeneity: Pathways to Treatment Resistance and Relapse in Human Glioblastoma. Annals of Oncology : Official Journal of the European Society For Medical Oncology. PMID 28407030 DOI: 10.1093/Annonc/Mdx169 |
0.352 |
|
| 2017 |
Zipin-Roitman A, Aqaqe N, Yassin M, Biechonski S, Amar M, van Delft MF, Gan OI, McDermott SP, Buzina A, Ketela T, Shlush L, Xie S, Voisin V, Moffat J, Minden MD, et al. SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress. Oncotarget. PMID 28187429 DOI: 10.18632/Oncotarget.15147 |
0.364 |
|
| 2017 |
Han H, Braunschweig U, Gonatopoulos-Pournatzis T, Weatheritt RJ, Hirsch CL, Ha KC, Radovani E, Nabeel-Shah S, Sterne-Weiler T, Wang J, O'Hanlon D, Pan Q, Ray D, Zheng H, Vizeacoumar F, ... ... Moffat J, et al. Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors. Molecular Cell. 65: 539-553.e7. PMID 28157508 DOI: 10.1016/J.Molcel.2017.01.011 |
0.351 |
|
| 2017 |
Manoranjan B, Venugopal C, Pavlovic Z, Bakhshinyan D, Kameda-Smith M, Subapanditha M, Mahendram S, Moffat J, Doble BW, Singh S. Abstract 5831: Activated Wnt signaling for the treatment of recurrent medulloblastoma Cancer Research. 77: 5831-5831. DOI: 10.1158/1538-7445.Am2017-5831 |
0.354 |
|
| 2017 |
Vora P, Chokshi C, Qazi M, Singh M, Venugopal C, Mahendram S, Adams J, Bakhshinyan D, London M, Singh J, Subapanditha M, McFarlane N, Pan J, Bramson J, Sidhu S, ... Moffat J, et al. Abstract 3758: The efficacy of CD133 BiTEs and CAR-T cells in preclinical model of glioblastoma Cancer Research. 77: 3758-3758. DOI: 10.1158/1538-7445.Am2017-3758 |
0.321 |
|
| 2017 |
Qazi M, Vora P, Chokshi C, Venugopal C, London M, Hu A, Subapandtiha M, Singh M, Adams J, Moffat J, Sidhu S, Singh SK. Abstract 3639: Therapeutic targeting of tumorigenic EphA2+/EphA3+ brain tumor initiating cells with bi-specific antibody in human glioblastoma Cancer Research. 77: 3639-3639. DOI: 10.1158/1538-7445.Am2017-3639 |
0.316 |
|
| 2017 |
Chokshi C, Tieu D, Vora P, Venugopal C, Chan K, Tong A, Brown K, Singh M, Moffat J, Singh S. Stem-42. Genome-Wide Crispr Screens In Brain Tumor Initiating Cells (Btics) Identify Potent Sensitizers Of Conventional Chemoradiotherapy. Neuro-Oncology. 19. DOI: 10.1093/Neuonc/Nox168.956 |
0.418 |
|
| 2017 |
Qazi M, Vora P, Venugopal C, Gorelik M, Singh M, Hu A, Subapanditha M, Chokshi C, Savage N, Yelle N, Adams J, Moffat J, Sidhu S, Singh S. IMMU-03. THERAPEUTIC TARGETING OF TUMORIGENIC
EphA2+/EphA3+ BRAIN TUMOR INITIATING CELLS WITH BISPECIFIC ANTIBODY IN HUMAN GLIOBLASTOMA Neuro-Oncology. 19: vi113-vi113. DOI: 10.1093/Neuonc/Nox168.462 |
0.313 |
|
| 2017 |
Singh M, Venugopal C, Vora P, Adams J, Pan J, Chokshi C, Murty N, Sidhu S, Moffat J, Singh S. CMET-35. PRELIMINARY SCREENING OF A NOVEL EpCAM BISPECIFIC T-CELL ENGAGER (BiTE) ANTIBODY TO TARGET A BMIC POPULATION IN HUMAN BRAIN METASTASES Neuro-Oncology. 19. DOI: 10.1093/Neuonc/Nox168.182 |
0.334 |
|
| 2016 |
Harris EA, Buzina A, Moffat J, McMillen DR. Design and experimental validation of small activating RNAs targeting an exogenous promoter in human cells. Acs Synthetic Biology. PMID 28033709 DOI: 10.1021/Acssynbio.6B00125 |
0.347 |
|
| 2016 |
Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, ... Moffat J, et al. Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nature Medicine. PMID 27869803 DOI: 10.1038/Nm.4219 |
0.465 |
|
| 2016 |
Le MX, Haddad D, Ling AK, Li C, So CC, Chopra A, Hu R, Angulo JF, Moffat J, Martin A. Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching. Scientific Reports. 6: 37215. PMID 27853268 DOI: 10.1038/Srep37215 |
0.345 |
|
| 2016 |
Lobo NC, Gedye C, Apostoli AJ, Brown KR, Paterson J, Stickle N, Robinette M, Fleshner N, Hamilton RJ, Kulkarni G, Zlotta A, Evans A, Finelli A, Moffat J, Jewett MA, et al. Efficient generation of patient-matched malignant and normal primary cell cultures from clear cell renal cell carcinoma patients: clinically relevant models for research and personalized medicine. Bmc Cancer. 16: 485. PMID 27422173 DOI: 10.1186/S12885-016-2539-Z |
0.366 |
|
| 2016 |
Hart T, Moffat J. BAGEL: a computational framework for identifying essential genes from pooled library screens. Bmc Bioinformatics. 17: 164. PMID 27083490 DOI: 10.1186/S12859-016-1015-8 |
0.402 |
|
| 2016 |
Gorelik M, Orlicky S, Sartori MA, Tang X, Marcon E, Kurinov I, Greenblatt JF, Tyers M, Moffat J, Sicheri F, Sidhu SS. Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface. Proceedings of the National Academy of Sciences of the United States of America. PMID 26976582 DOI: 10.1073/Pnas.1519389113 |
0.319 |
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| 2016 |
Zhang W, Wu KP, Sartori MA, Kamadurai HB, Ordureau A, Jiang C, Mercredi PY, Murchie R, Hu J, Persaud A, Mukherjee M, Li N, Doye A, Walker JR, Sheng Y, ... ... Moffat J, et al. System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Molecular Cell. PMID 26949039 DOI: 10.1016/J.Molcel.2016.02.005 |
0.338 |
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| 2016 |
Nim S, Jeon J, Corbi-Verge C, Seo MH, Ivarsson Y, Moffat J, Tarasova N, Kim PM. Pooled screening for antiproliferative inhibitors of protein-protein interactions. Nature Chemical Biology. PMID 26900867 DOI: 10.1038/Nchembio.2026 |
0.447 |
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| 2016 |
Chang Q, Chandrashekhar M, Ketela T, Fedyshyn Y, Moffat J, Hedley D. Cytokinetic effects of Wee1 disruption in pancreatic cancer. Cell Cycle (Georgetown, Tex.). 0. PMID 26890070 DOI: 10.1080/15384101.2016.1138188 |
0.436 |
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| 2016 |
Marcotte R, Sayad A, Brown KR, Sanchez-Garcia F, Reimand J, Haider M, Virtanen C, Bradner JE, Bader GD, Mills GB, Pe'er D, Moffat J, Neel BG. Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance. Cell. 164: 293-309. PMID 26771497 DOI: 10.1016/J.Cell.2015.11.062 |
0.392 |
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| 2016 |
Vora P, Qazi M, Chokshi C, Venugopal C, London M, Hu A, McFarlane N, Subapanditha M, Singh M, Mahendram S, Adams J, Moffat J, Sidhu S, Singh S. Abstract B092: Therapeutic targeting of tumorigenic EphA2+/EphA3+ brain tumor initiating cells with bi-specific antibody in glioblastoma Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B092 |
0.367 |
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| 2016 |
Vora P, Chokshi C, Qazi M, Venugopal C, Mahendram S, Singh M, Adams J, Bakhshinyan D, London M, Subapanditha M, McFarlane N, Pan J, Bramson J, Moffat J, Sidhu S, et al. Abstract B079: The efficacy of CD133 BiTEs and CAR-T cells in preclinical model of recurrent glioblastoma Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B079 |
0.312 |
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| 2016 |
Lobo N, Gedye C, Brown KR, Paterson J, Stickle N, Moffat J, Jewett MAS, Ailles LE. Abstract B09: Efficient generation of patient-matched malignant and normal primary cell cultures from clear cell renal cell carcinoma patients: clinically relevant models for research and personalized medicine Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-B09 |
0.378 |
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| 2016 |
Steinhart Z, Hart T, Sidhu S, Moffat J, Angers S. Abstract IA13: Inhibiting the Wnt pathway with selective anti-Frizzled synthetic antibodies Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Devbiolca15-Ia13 |
0.379 |
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| 2016 |
Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, Macleod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Driks P, Sidhu S, Roth FP, Rissland OS, Durocher D, ... ... Moffat J, et al. Abstract PR03: High-resolution detection of fitness genes and genotype-specific cancer vulnerabilities with CRISPR-Cas9 screens Cancer Research. 76. DOI: 10.1158/1538-7445.Fbcr15-Pr03 |
0.487 |
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| 2016 |
Kondratyev M, Pesic A, Marastoni S, Ketela T, Moffat J, Virtanen C, Sayad A, Bashkurov M, Dati A, Ailles L, Grenman R, Koritzinsky M, Wouters B. Abstract 3794: Novel therapeutic targets in head and neck cancer Cancer Research. 76: 3794-3794. DOI: 10.1158/1538-7445.Am2016-3794 |
0.407 |
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| 2016 |
Tomic J, McLaughlin M, Geyer R, Sidhu S, Moffat J. Abstract 2972: Development and characterization of synthetic antibodies with a human framework that directly link metabolism to immune system in cancer cells Cancer Research. 76: 2972-2972. DOI: 10.1158/1538-7445.Am2016-2972 |
0.379 |
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| 2016 |
Singh SK, Singh M, Venugopal C, McFarlane N, Bakhshinyan D, Dhillon M, Mahendram S, Brown K, Tong A, Durrer K, Tokar T, Hallett R, Hassell J, Jurisica I, Moffat J. Abstract 2680: Development and application of a novel model of human lung-to-brain metastasis: identification of TWIST2 and SPOCK1 as unique regulators of brain metastases Cancer Research. 76: 2680-2680. DOI: 10.1158/1538-7445.Am2016-2680 |
0.351 |
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| 2016 |
Nixon AM, Brown KR, Haynes J, Donovan LK, Taylor MD, O’Brien CW, Moffat J. Abstract 2384: High-complexity neutral genomic barcoding technology reveals extensive clonal dynamics in multiple human cancer model systems Cancer Research. 76: 2384-2384. DOI: 10.1158/1538-7445.Am2016-2384 |
0.4 |
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| 2016 |
Chandrashekhar M, Arreger M, Seetharaman A, Hart T, Moffat J. Abstract 233: Identification of cancer vulnerabilities to metabolic perturbation using genome wide CRISPR screens Cancer Research. 76: 233-233. DOI: 10.1158/1538-7445.Am2016-233 |
0.507 |
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| 2016 |
Vora P, Venugopal C, Mahendram S, Chokshi C, Qazi M, Subapanditha M, Singh M, Bakhshinyan D, Bezverbnaya K, Adams J, McFarlane N, Sidhu S, Moffat J, Bramson J, Singh S. Abstract 2300: Human CD133-specific chimeric antigen receptor (CAR) modified T cells target patient-derived glioblastoma brain tumors Cancer Research. 76: 2300-2300. DOI: 10.1158/1538-7445.Am2016-2300 |
0.301 |
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| 2016 |
Vora P, Venugopal C, Adams J, Pan J, Chokshi C, Qazi M, Subapanditha M, Singh M, Bakhshinyan D, Bezverbnaya K, McFarlane N, Bramson J, Sidhu S, Moffat J, Singh S. Abstract 1481: Preclinical validation of a novel CD133/CD3 bispecific T-cell engager (BiTE) antibody to target patient-derived glioblastoma cells Cancer Research. 76: 1481-1481. DOI: 10.1158/1538-7445.Am2016-1481 |
0.324 |
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| 2016 |
Singh M, Venugopal C, Tokar T, Brown K, McFarlane N, Bakhshinyan D, Vora P, Qazi M, Mahendram S, Vijaykumar T, Manoranjan B, Tong A, Durrer K, Murty N, Hallet R, ... ... Moffat J, et al. TMOD-23. DEVELOPMENT AND APPLICATION OF A NOVEL MODEL OF HUMAN LUNG-TO- BRAIN METASTASIS TO IDENTIFY GENETIC REGULATORS OF BRAIN METASTASIS INITIATING CELLS Neuro-Oncology. 18: vi211-vi212. DOI: 10.1093/Neuonc/Now212.893 |
0.303 |
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| 2016 |
Singh M, Venugopal C, Tokar T, Brown KR, McFarlane N, Bakhshinyan D, Vijayakumar T, Manoranjan B, Mahendram S, Vora P, Qazi M, Dhillon M, Tong A, Durrer K, Murty N, ... ... Moffat J, et al. OS2 - 166 A Novel Model of Human Lung-to-Brain Metastasis and its Application to the Identification of Essential Metastatic Regulatory Genes Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques. 43: S2-S2. DOI: 10.1017/Cjn.2016.333 |
0.363 |
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| 2015 |
Shire K, Wong AI, Tatham MH, Anderson OF, Ripsman D, Gulstene S, Moffat J, Hay RT, Frappier L. Identification of RNF168 as a PML nuclear body regulator. Journal of Cell Science. PMID 26675234 DOI: 10.1242/Jcs.176446 |
0.342 |
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| 2015 |
Toledo CM, Ding Y, Hoellerbauer P, Davis RJ, Basom R, Girard EJ, Lee E, Corrin P, Hart T, Bolouri H, Davison J, Zhang Q, Hardcastle J, Aronow BJ, Plaisier CL, ... ... Moffat J, et al. Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells. Cell Reports. PMID 26673326 DOI: 10.1016/J.Celrep.2015.11.021 |
0.467 |
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| 2015 |
Gupta GD, Coyaud É, Gonçalves J, Mojarad BA, Liu Y, Wu Q, Gheiratmand L, Comartin D, Tkach JM, Cheung SW, Bashkurov M, Hasegan M, Knight JD, Lin ZY, Schueler M, ... ... Moffat J, et al. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell. 163: 1484-99. PMID 26638075 DOI: 10.1016/J.Cell.2015.10.065 |
0.335 |
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| 2015 |
Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, ... ... Moffat J, et al. High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities. Cell. PMID 26627737 DOI: 10.1016/J.Cell.2015.11.015 |
0.48 |
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| 2015 |
Bailey ML, Singh T, Mero P, Moffat J, Hieter P. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. Genetics. 201: 885-95. PMID 26354767 DOI: 10.1534/Genetics.115.180653 |
0.459 |
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| 2015 |
Pandyra AA, Mullen PJ, Goard CA, Ericson E, Sharma P, Kalkat M, Yu R, Pong JT, Brown KR, Hart T, Gebbia M, Lang KS, Giaever G, Nislow C, Moffat J, et al. Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. Oncotarget. PMID 26353928 DOI: 10.18632/Oncotarget.4817 |
0.431 |
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| 2015 |
Huang H, Economopoulos NO, Liu BA, Uetrecht A, Gu J, Jarvik N, Nadeem V, Pawson T, Moffat J, Miersch S, Sidhu SS. Selection of recombinant anti-SH3 domain antibodies by high-throughput phage display. Protein Science : a Publication of the Protein Society. 24: 1890-900. PMID 26332758 DOI: 10.1002/Pro.2799 |
0.301 |
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| 2015 |
Hunter FW, Young RJ, Shalev Z, Vellanki RN, Wang J, Gu Y, Joshi N, Sreebhavan S, Weinreb I, Goldstein DP, Moffat J, Ketela T, Brown KR, Koritzinsky M, Solomon B, et al. Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs. Cancer Research. PMID 26297733 DOI: 10.1158/0008-5472.Can-15-1107 |
0.383 |
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| 2015 |
Workenhe ST, Ketela T, Moffat J, Cuddington BP, Mossman KL. Genome-wide lentiviral shRNA screen identifies serine/arginine-rich splicing factor 2 as a determinant of oncolytic virus activity in breast cancer cells. Oncogene. 35: 2465-74. PMID 26257065 DOI: 10.1038/Onc.2015.303 |
0.408 |
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| 2015 |
Aregger M, Hart T, Moffat J. Extensive mapping of an innate immune network with CRISPR. Molecular Systems Biology. 11: 821. PMID 26208794 DOI: 10.15252/Msb.20156373 |
0.389 |
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| 2015 |
Vu V, Verster AJ, Schertzberg M, Chuluunbaatar T, Spensley M, Pajkic D, Hart GT, Moffat J, Fraser AG. Natural Variation in Gene Expression Modulates the Severity of Mutant Phenotypes. Cell. 162: 391-402. PMID 26186192 DOI: 10.1016/J.Cell.2015.06.037 |
0.339 |
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| 2015 |
Cole A, Wang Z, Coyaud E, Voisin V, Gronda M, Jitkova Y, Mattson R, Hurren R, Babovic S, Maclean N, Restall I, Wang X, Jeyaraju DV, Sukhai MA, Prabha S, ... ... Moffat J, et al. Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia. Cancer Cell. 27: 864-76. PMID 26058080 DOI: 10.1016/J.Ccell.2015.05.004 |
0.361 |
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| 2015 |
Koh JL, Chong YT, Friesen H, Moses A, Boone C, Andrews BJ, Moffat J. CYCLoPs: A Comprehensive Database Constructed from Automated Analysis of Protein Abundance and Subcellular Localization Patterns in Saccharomyces cerevisiae. G3 (Bethesda, Md.). 5: 1223-32. PMID 26048563 DOI: 10.1534/G3.115.017830 |
0.596 |
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| 2015 |
Chong YT, Koh JL, Friesen H, Duffy K, Cox MJ, Moses A, Moffat J, Boone C, Andrews BJ. Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis. Cell. 161: 1413-24. PMID 26046442 DOI: 10.1016/J.Cell.2015.04.051 |
0.574 |
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| 2015 |
Trzci?ska-Daneluti AM, Chen A, Nguyen L, Murchie R, Jiang C, Moffat J, Pelletier L, Rotin D. RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR. Molecular & Cellular Proteomics : McP. 14: 1569-83. PMID 25825526 DOI: 10.1074/Mcp.M114.046375 |
0.389 |
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| 2015 |
St-Germain JR, Taylor P, Zhang W, Li Z, Ketela T, Moffat J, Neel BG, Trudel S, Moran MF. Differential regulation of FGFR3 by PTPN1 and PTPN2. Proteomics. 15: 419-33. PMID 25311528 DOI: 10.1002/Pmic.201400259 |
0.336 |
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| 2015 |
Marcotte R, Sayad A, Iorio C, Moffat J, Neel BG. Abstract A2-07: Integrative functional genomics of breast cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A2-07 |
0.45 |
|
| 2014 |
Radulovich N, Leung L, Ibrahimov E, Navab R, Sakashita S, Zhu CQ, Kaufman E, Lockwood WW, Thu KL, Fedyshyn Y, Moffat J, Lam WL, Tsao MS. Coiled-coil domain containing 68 (CCDC68) demonstrates a tumor-suppressive role in pancreatic ductal adenocarcinoma. Oncogene. PMID 25381825 DOI: 10.1038/Onc.2014.357 |
0.359 |
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| 2014 |
Jeon J, Nim S, Teyra J, Datti A, Wrana JL, Sidhu SS, Moffat J, Kim PM. A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening. Genome Medicine. 6: 57. PMID 25165489 DOI: 10.1186/S13073-014-0057-7 |
0.339 |
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| 2014 |
Hart T, Brown KR, Sircoulomb F, Rottapel R, Moffat J. Measuring error rates in genomic perturbation screens: gold standards for human functional genomics. Molecular Systems Biology. 10: 733. PMID 24987113 DOI: 10.15252/Msb.20145216 |
0.445 |
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| 2014 |
Arnoldo A, Kittanakom S, Heisler LE, Mak AB, Shukalyuk AI, Torti D, Moffat J, Giaever G, Nislow C. A genome scale overexpression screen to reveal drug activity in human cells. Genome Medicine. 6: 32. PMID 24944581 DOI: 10.1186/Gm549 |
0.419 |
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| 2014 |
Petschnigg J, Groisman B, Kotlyar M, Taipale M, Zheng Y, Kurat CF, Sayad A, Sierra JR, Mattiazzi Usaj M, Snider J, Nachman A, Krykbaeva I, Tsao MS, Moffat J, Pawson T, et al. The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nature Methods. 11: 585-92. PMID 24658140 DOI: 10.1038/Nmeth.2895 |
0.366 |
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| 2014 |
Mak AB, Schnegg C, Lai CY, Ghosh S, Yang MH, Moffat J, Hsu MY. CD133-targeted niche-dependent therapy in cancer: a multipronged approach. The American Journal of Pathology. 184: 1256-62. PMID 24589338 DOI: 10.1016/J.Ajpath.2014.01.008 |
0.324 |
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| 2014 |
Mak AB, Pehar M, Nixon AM, Williams RA, Uetrecht AC, Puglielli L, Moffat J. Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation. Journal of Molecular Biology. 426: 2175-82. PMID 24556617 DOI: 10.1016/J.Jmb.2014.02.012 |
0.322 |
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| 2014 |
Ivarsson Y, Arnold R, McLaughlin M, Nim S, Joshi R, Ray D, Liu B, Teyra J, Pawson T, Moffat J, Li SS, Sidhu SS, Kim PM. Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes. Proceedings of the National Academy of Sciences of the United States of America. 111: 2542-7. PMID 24550280 DOI: 10.1073/Pnas.1312296111 |
0.315 |
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| 2014 |
Deng T, Liu JC, Chung PE, Uehling D, Aman A, Joseph B, Ketela T, Jiang Z, Schachter NF, Rottapel R, Egan SE, Al-Awar R, Moffat J, Zacksenhaus E. shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer. Cancer Research. 74: 2119-30. PMID 24487029 DOI: 10.1158/0008-5472.Can-13-2138 |
0.363 |
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| 2014 |
Arnoldo A, Kittanakom S, Heisler LE, Mak AB, Shukalyuk AI, Torti D, Moffat J, Giaever G, Nislow C. A genome scale overexpression screen to reveal drug activity in human cells Genome Medicine. 6. DOI: 10.1186/gm549 |
0.301 |
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| 2014 |
Leith SJ, Kuruvilla SE, Moffat J, Chambers AF, Turley EA, Chin JL, Leong HS. Abstract 3432: A genome-wide shRNA screen for suppressors of prostate cancer cell invasion Cancer Research. 74: 3432-3432. DOI: 10.1158/1538-7445.Am2014-3432 |
0.433 |
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| 2014 |
Radulovich N, Leung L, Ibrahimov E, Navab R, Sakashita S, Lockwood W, Thu K, Fedeshyn Y, Moffat J, Lam W, Tsao M. Abstract 2462: Coiled-coil domain 68 (CCDC68) plays a tumor suppressive role in pancreatic adenocarcinoma Cancer Research. 74: 2462-2462. DOI: 10.1158/1538-7445.Am2014-2462 |
0.434 |
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| 2013 |
Vizeacoumar FJ, Arnold R, Vizeacoumar FS, Chandrashekhar M, Buzina A, Young JT, Kwan JH, Sayad A, Mero P, Lawo S, Tanaka H, Brown KR, Baryshnikova A, Mak AB, Fedyshyn Y, ... ... Moffat J, et al. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Molecular Systems Biology. 9: 696. PMID 24104479 DOI: 10.1038/Msb.2013.54 |
0.626 |
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| 2013 |
Samuel N, Sayad A, Wilson G, Lemire M, Brown KR, Muthuswamy L, Hudson TJ, Moffat J. Integrated genomic, transcriptomic, and RNA-interference analysis of genes in somatic copy number gains in pancreatic ductal adenocarcinoma. Pancreas. 42: 1016-26. PMID 23851435 DOI: 10.1097/Mpa.0B013E318287D043 |
0.355 |
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| 2013 |
Kittanakom S, Arnoldo A, Brown KR, Wallace I, Kunavisarut T, Torti D, Heisler LE, Surendra A, Moffat J, Giaever G, Nislow C. Miniature short hairpin rna screens to characterize antiproliferative drugs G3: Genes, Genomes, Genetics. 3: 1375-1387. PMID 23797109 DOI: 10.1534/G3.113.006437 |
0.419 |
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| 2013 |
Mak AB, Moffat J. RNA interference screens to uncover membrane protein biology. Briefings in Functional Genomics. 12: 422-9. PMID 23793263 DOI: 10.1093/Bfgp/Elt022 |
0.422 |
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| 2013 |
Han H, Irimia M, Ross PJ, Sung HK, Alipanahi B, David L, Golipour A, Gabut M, Michael IP, Nachman EN, Wang E, Trcka D, Thompson T, O'Hanlon D, Slobodeniuc V, ... ... Moffat J, et al. MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature. 498: 241-5. PMID 23739326 DOI: 10.1038/Nature12270 |
0.429 |
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| 2013 |
Vojvodic M, Hansford LM, Morozova O, Blakely KM, Taylor P, Fathers KE, Moffat J, Marra M, Smith KM, Moran MF, Kaplan DR. A phosphoproteomics approach to identify candidate kinase inhibitor pathway targets in lymphoma-like primary cell lines. Current Drug Discovery Technologies. 10: 283-304. PMID 23701117 DOI: 10.2174/15701638113109990001 |
0.786 |
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| 2013 |
Hart T, Moffat J. Scaling up the systematic hunt for mammalian genetic interactions. Nature Methods. 10: 397-9. PMID 23629415 DOI: 10.1038/Nmeth.2449 |
0.31 |
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| 2013 |
Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, et al. Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate. Cell. 152: 1008-20. PMID 23452850 DOI: 10.1016/J.Cell.2013.01.056 |
0.312 |
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| 2013 |
Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, ... ... Moffat J, et al. A strategy for modulation of enzymes in the ubiquitin system. Science (New York, N.Y.). 339: 590-5. PMID 23287719 DOI: 10.1126/Science.1230161 |
0.31 |
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| 2013 |
Marcotte R, Sayad A, Iorio C, Haider M, Moffat J, Neel BG. Abstract PR07: Integrative functional genomics of breast cancer Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-Pr07 |
0.441 |
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| 2013 |
Pong J, Pandyra A, Goard C, Ericson E, Brown K, Ylanko J, Andrews D, Nislow C, Moffat J, Penn L. Abstract PR12: A genome-wide shRNA screen reveals that inhibiting kinases potentiates the anti-breast cancer activity of fluvastatin Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-Pr12 |
0.426 |
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| 2013 |
Marcotte R, Sayad A, Haider M, Brown K, Ketela T, Moffat J, Neel BG. Abstract PR01: Functional characterization of breast cancer using pooled lentivirus shRNA screens Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-Pr01 |
0.439 |
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| 2013 |
Milyavsky M, Gan O, van Delft M, McDermott S, Buzina A, Ketela T, Shlush L, Xie S, Voisin V, Shenhav L, Moffat J, Dick J. Genome-wide shRNA screening approach towards identification and characterization of therapy resistance determinants in leukemia Experimental Hematology. 41: S20. DOI: 10.1016/J.Exphem.2013.05.077 |
0.348 |
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| 2012 |
Mak AB, Nixon AM, Kittanakom S, Stewart JM, Chen GI, Curak J, Gingras AC, Mazitschek R, Neel BG, Stagljar I, Moffat J. Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation. Cell Reports. 2: 951-63. PMID 23084749 DOI: 10.1016/J.Celrep.2012.09.016 |
0.322 |
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| 2012 |
Beheshti Zavareh R, Sukhai MA, Hurren R, Gronda M, Wang X, Simpson CD, Maclean N, Zih F, Ketela T, Swallow CJ, Moffat J, Rose DR, Schachter H, Schimmer AD, Dennis JW. Suppression of cancer progression by MGAT1 shRNA knockdown. Plos One. 7: e43721. PMID 22957033 DOI: 10.1371/Journal.Pone.0043721 |
0.385 |
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| 2012 |
Tkach JM, Yimit A, Lee AY, Riffle M, Costanzo M, Jaschob D, Hendry JA, Ou J, Moffat J, Boone C, Davis TN, Nislow C, Brown GW. Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nature Cell Biology. 14: 966-76. PMID 22842922 DOI: 10.1038/Ncb2549 |
0.632 |
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| 2012 |
Eastwood MD, Cheung SW, Lee KY, Moffat J, Meneghini MD. Developmentally programmed nuclear destruction during yeast gametogenesis. Developmental Cell. 23: 35-44. PMID 22727375 DOI: 10.1016/J.Devcel.2012.05.005 |
0.311 |
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| 2012 |
Mak AB, Moffat J. A versatile lentiviral expression system to identify mammalian protein-protein interactions. Methods (San Diego, Calif.). 57: 409-16. PMID 22713554 DOI: 10.1016/J.Ymeth.2012.06.005 |
0.366 |
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| 2012 |
Marcotte R, Brown KR, Suarez F, Sayad A, Karamboulas K, Krzyzanowski PM, Sircoulomb F, Medrano M, Fedyshyn Y, Koh JL, van Dyk D, Fedyshyn B, Luhova M, Brito GC, Vizeacoumar FJ, ... ... Moffat J, et al. Essential gene profiles in breast, pancreatic, and ovarian cancer cells. Cancer Discovery. 2: 172-89. PMID 22585861 DOI: 10.1158/2159-8290.Cd-11-0224 |
0.427 |
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| 2012 |
Simpson CD, Hurren R, Kasimer D, MacLean N, Eberhard Y, Ketela T, Moffat J, Schimmer AD. A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance Apoptosis. 17: 666-678. PMID 22488300 DOI: 10.1007/S10495-012-0723-4 |
0.431 |
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| 2012 |
Mak AB, Nixon AM, Moffat J. The mixed lineage leukemia (MLL) fusion-associated gene AF4 promotes CD133 transcription. Cancer Research. 72: 1929-34. PMID 22337994 DOI: 10.1158/0008-5472.Can-11-3589 |
0.374 |
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| 2012 |
Rajan S, Chu Pham Dang H, Djambazian H, Zuzan H, Fedyshyn Y, Ketela T, Moffat J, Hudson TJ, Sladek R. Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiological Genomics. 44: 183-97. PMID 22147266 DOI: 10.1152/Physiolgenomics.00093.2011 |
0.379 |
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| 2012 |
Koh JL, Brown KR, Sayad A, Kasimer D, Ketela T, Moffat J. COLT-Cancer: functional genetic screening resource for essential genes in human cancer cell lines. Nucleic Acids Research. 40: D957-63. PMID 22102578 DOI: 10.1093/Nar/Gkr959 |
0.445 |
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| 2012 |
Chang Q, Moffat J, Hedley DW. Abstract A26: Targeting Wee1 in primary pancreatic cancer xenografts. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-A26 |
0.375 |
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| 2012 |
Marcotte R, Brown K, Sayad A, Haider M, Ketela T, Moffat J, Neel BG. Abstract 5084: Functional genomic classification of breast cancer using pooled lentivirus shRNA screens Cancer Research. 72: 5084-5084. DOI: 10.1158/1538-7445.Am2012-5084 |
0.462 |
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| 2012 |
Samuel N, Lemire M, Wilson G, Sayad A, Muthuswamy L, Moffat J, Hudson TJ. Abstract 1853: Identification and characterization of genes in regions of recurrent genomic gain as putative therapeutic targets in pancreatic ductal adenocarcinoma Cancer Research. 72: 1853-1853. DOI: 10.1158/1538-7445.Am2012-1853 |
0.354 |
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| 2012 |
Sierra R, Chang A, Moffat J, Neel BG, Tsao M. Abstract B34: Overcoming resistance to EGFR-Tyrosine Kinase Inhibitor therapy in non-small cell lung cancer Clinical Cancer Research. 18: B34-B34. DOI: 10.1158/1538-7445.Am2012-1232 |
0.351 |
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| 2011 |
Skrti? M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z, Hurren R, Jitkova Y, Gronda M, Maclean N, Lai CK, Eberhard Y, Bartoszko J, Spagnuolo P, Rutledge AC, ... ... Moffat J, et al. Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell. 20: 674-88. PMID 22094260 DOI: 10.1016/J.Ccr.2011.10.015 |
0.414 |
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| 2011 |
Mak AB, Blakely KM, Williams RA, Penttilä PA, Shukalyuk AI, Osman KT, Kasimer D, Ketela T, Moffat J. CD133 protein N-glycosylation processing contributes to cell surface recognition of the primitive cell marker AC133 epitope. The Journal of Biological Chemistry. 286: 41046-56. PMID 21937449 DOI: 10.1074/Jbc.M111.261545 |
0.787 |
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| 2011 |
Blakely K, Ketela T, Moffat J. Pooled lentiviral shRNA screening for functional genomics in mammalian cells. Methods in Molecular Biology (Clifton, N.J.). 781: 161-82. PMID 21877282 DOI: 10.1007/978-1-61779-276-2_9 |
0.8 |
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| 2011 |
Ketela T, Heisler LE, Brown KR, Ammar R, Kasimer D, Surendra A, Ericson E, Blakely K, Karamboulas D, Smith AM, Durbic T, Arnoldo A, Cheung-Ong K, Koh JL, Gopal S, ... ... Moffat J, et al. A comprehensive platform for highly multiplexed mammalian functional genetic screens. Bmc Genomics. 12: 213. PMID 21548937 DOI: 10.1186/1471-2164-12-213 |
0.799 |
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| 2011 |
Eberhard Y, Gronda M, Hurren R, Datti A, MacLean N, Ketela T, Moffat J, Wrana JL, Schimmer AD. Inhibition of SREBP1 sensitizes cells to death ligands Oncotarget. 2: 186-196. PMID 21406729 DOI: 10.18632/Oncotarget.239 |
0.322 |
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| 2011 |
Skrtic M, Sriskanthadevan S, Livak B, Gebbia M, Wang X, Wang Z, Hurren R, Jitkova Y, Gronda M, Maclean N, Lai C, Eberhard Y, Bartoszko J, Spagnuolo PA, Rutledge A, ... ... Moffat J, et al. Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML) Blood. 118: 233-233. DOI: 10.1182/Blood.V118.21.233.233 |
0.384 |
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| 2011 |
Gan OI, Milyavsky M, van Delft MF, Buzina A, Kalatskaya I, Ketela T, Stein L, Moffat J, Dick JE. Genome-Wide shRNA Screen for DNA Damage Response Regulators in Human Hematopoietic Stem and Progenitor Cells Blood. 118: 1289-1289. DOI: 10.1182/Blood.V118.21.1289.1289 |
0.419 |
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| 2011 |
Zavareh RB, Hurren R, Gronda M, Sukhai MA, Simpson CD, Wang X, MacLean NA, Ketela T, Moffat J, Rose DR, Schachter H, Dennis JW, Schimmer AD. Abstract 1484: Inhibition of the glycosylation enzyme Mgat1 blocks migration, invasion and metastasis of malignant cells Cancer Research. 71: 1484-1484. DOI: 10.1158/1538-7445.Am2011-1484 |
0.396 |
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| 2011 |
Simpson CD, Hurren R, MacLean N, Eberhard Y, Ketela T, Moffat J, Schimmer AD. Abstract A22: A genome-wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A22 |
0.429 |
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| 2010 |
Chung J, Lau J, Cheng LS, Grant RI, Robinson F, Ketela T, Reis PP, Roche O, Kamel-Reid S, Moffat J, Ohh M, Perez-Ordonez B, Kaplan DR, Irwin MS. SATB2 augments ΔNp63α in head and neck squamous cell carcinoma. Embo Reports. 11: 777-83. PMID 20829881 DOI: 10.1038/Embor.2010.125 |
0.356 |
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| 2010 |
Smith KM, Datti A, Fujitani M, Grinshtein N, Zhang L, Morozova O, Blakely KM, Rotenberg SA, Hansford LM, Miller FD, Yeger H, Irwin MS, Moffat J, Marra MA, Baruchel S, et al. Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens. Embo Molecular Medicine. 2: 371-84. PMID 20721990 DOI: 10.1002/Emmm.201000093 |
0.78 |
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| 2010 |
Morozova O, Vojvodic M, Grinshtein N, Hansford LM, Blakely KM, Maslova A, Hirst M, Cezard T, Morin RD, Moore R, Smith KM, Miller F, Taylor P, Thiessen N, Varhol R, ... ... Moffat J, et al. System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 4572-82. PMID 20651058 DOI: 10.1158/1078-0432.Ccr-10-0627 |
0.788 |
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| 2010 |
Mak AB, Ni Z, Hewel JA, Chen GI, Zhong G, Karamboulas K, Blakely K, Smiley S, Marcon E, Roudeva D, Li J, Olsen JB, Wan C, Punna T, Isserlin R, ... ... Moffat J, et al. A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Molecular & Cellular Proteomics : McP. 9: 811-23. PMID 20305087 DOI: 10.1074/Mcp.M000002-Mcp201 |
0.776 |
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| 2010 |
Xu GW, Ali M, Wood TE, Wong D, Maclean N, Wang X, Gronda M, Skrtic M, Li X, Hurren R, Mao X, Venkatesan M, Beheshti Zavareh R, Ketela T, Reed JC, ... ... Moffat J, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood. 115: 2251-9. PMID 20075161 DOI: 10.1182/Blood-2009-07-231191 |
0.359 |
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| 2010 |
Wood TE, Dalili S, Simpson CD, Sukhai MA, Hurren R, Anyiwe K, Mao X, Suarez Saiz F, Gronda M, Eberhard Y, MacLean N, Ketela T, Reed JC, Moffat J, Minden MD, et al. Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Molecular Cancer Therapeutics. 9: 246-56. PMID 20053768 DOI: 10.1158/1535-7163.Mct-09-0495 |
0.325 |
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| 2010 |
Hansford LM, Morozova O, Lipman T, Blakely K, Ohira M, Marrano P, Angelini P, Moffat J, Thiele CJ, Thorner P, Dick J, Nakagawara A, Irwin M, Marra M, Kaplan DR. Abstract 12: Metastatic neuroblastoma cancer stem cells display a mixed phenotype of tumor and niche origin required for survival Cancer Research. 70: 12-12. DOI: 10.1158/1538-7445.Am10-12 |
0.761 |
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| 2010 |
Mak AB, Kittanakom S, Chen GI, Mazitschek R, Gingras A, Stagljar I, Moffat J. Abstract A11: Regulation of CD133 by the tubulin deacetylase HDAC6 can alter cancer cell state Clinical Cancer Research. 16. DOI: 10.1158/1078-0432.Tcmusa10-A11 |
0.387 |
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| 2009 |
Huang D, Kaluarachchi S, van Dyk D, Friesen H, Sopko R, Ye W, Bastajian N, Moffat J, Sassi H, Costanzo M, Andrews BJ. Dual regulation by pairs of cyclin-dependent protein kinases and histone deacetylases controls G1 transcription in budding yeast. Plos Biology. 7: e1000188. PMID 19823668 DOI: 10.1371/Journal.Pbio.1000188 |
0.726 |
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| 2009 |
Jones TR, Carpenter AE, Lamprecht MR, Moffat J, Silver SJ, Grenier JK, Castoreno AB, Eggert US, Root DE, Golland P, Sabatini DM. Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning. Proceedings of the National Academy of Sciences of the United States of America. 106: 1826-31. PMID 19188593 DOI: 10.1073/Pnas.0808843106 |
0.339 |
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| 2007 |
Moffat J, Reiling JH, Sabatini DM. Off-target effects associated with long dsRNAs in Drosophila RNAi screens. Trends in Pharmacological Sciences. 28: 149-51. PMID 17350110 DOI: 10.1016/J.Tips.2007.02.009 |
0.391 |
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| 2006 |
Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Developmental Cell. 11: 859-71. PMID 17141160 DOI: 10.1016/J.Devcel.2006.10.007 |
0.305 |
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| 2006 |
Carpenter AE, Jones TR, Lamprecht MR, Clarke C, Kang IH, Friman O, Guertin DA, Chang JH, Lindquist RA, Moffat J, Golland P, Sabatini DM. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biology. 7: R100. PMID 17076895 DOI: 10.1186/Gb-2006-7-10-R100 |
0.395 |
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| 2006 |
Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 124: 1283-98. PMID 16564017 DOI: 10.1016/J.Cell.2006.01.040 |
0.467 |
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| 2006 |
Moffat J, Sabatini DM. Building mammalian signalling pathways with RNAi screens Nature Reviews Molecular Cell Biology. 7: 177-187. PMID 16496020 DOI: 10.1038/Nrm1860 |
0.381 |
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| 2004 |
Mnaimneh S, Davierwala AP, Haynes J, Moffat J, Peng WT, Zhang W, Yang X, Pootoolal J, Chua G, Lopez A, Trochesset M, Morse D, Krogan NJ, Hiley SL, Li Z, et al. Exploration of essential gene functions via titratable promoter alleles. Cell. 118: 31-44. PMID 15242642 DOI: 10.1016/J.Cell.2004.06.013 |
0.618 |
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| 2004 |
Moffat J, Andrews B. Late-G1 cyclin-CDK activity is essential for control of cell morphogenesis in budding yeast. Nature Cell Biology. 6: 59-66. PMID 14688790 DOI: 10.1038/Ncb1078 |
0.593 |
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| 2003 |
Willis KA, Barbara KE, Menon BB, Moffat J, Andrews B, Santangelo GM. The global transcriptional activator of Saccharomyces cerevisiae, Gcr1p, mediates the response to glucose by stimulating protein synthesis and CLN-dependent cell cycle progression. Genetics. 165: 1017-29. PMID 14668361 |
0.555 |
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| 2003 |
Moffat J, Andrews B. Ac'septin' a signal: kinase regulation by septins. Developmental Cell. 5: 528-30. PMID 14536051 DOI: 10.1016/S1534-5807(03)00301-0 |
0.564 |
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| 2002 |
Huang D, Moffat J, Andrews B. Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity. Molecular and Cellular Biology. 22: 5076-88. PMID 12077337 DOI: 10.1128/Mcb.22.14.5076-5088.2002 |
0.655 |
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| 2001 |
McBride HJ, Sil A, Measday V, Yu Y, Moffat J, Maxon ME, Herskowitz I, Andrews B, Stillman DJ. The protein kinase Pho85 is required for asymmetric accumulation of the Ash1 protein in Saccharomyces cerevisiae. Molecular Microbiology. 42: 345-53. PMID 11703659 DOI: 10.1046/J.1365-2958.2001.02601.X |
0.703 |
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| 2001 |
Baetz K, Moffat J, Haynes J, Chang M, Andrews B. Transcriptional coregulation by the cell integrity mitogen-activated protein kinase Slt2 and the cell cycle regulator Swi4. Molecular and Cellular Biology. 21: 6515-28. PMID 11533240 DOI: 10.1128/Mcb.21.19.6515-6528.2001 |
0.643 |
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| 2000 |
Moffat J, Huang D, Andrews B. Functions of Pho85 cyclin-dependent kinases in budding yeast. Progress in Cell Cycle Research. 4: 97-106. PMID 10740818 DOI: 10.1007/978-1-4615-4253-7_9 |
0.613 |
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| 2000 |
Measday V, McBride H, Moffat J, Stillman D, Andrews B. Interactions between Pho85 cyclin-dependent kinase complexes and the Swi5 transcription factor in budding yeast. Molecular Microbiology. 35: 825-34. PMID 10692159 DOI: 10.1046/J.1365-2958.2000.01754.X |
0.643 |
|
| 1999 |
Huang D, Patrick G, Moffat J, Tsai LH, Andrews B. Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 96: 14445-50. PMID 10588725 DOI: 10.1073/Pnas.96.25.14445 |
0.591 |
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| 1998 |
Huang D, Moffat J, Wilson WA, Moore L, Cheng C, Roach PJ, Andrews B. Cyclin partners determine Pho85 protein kinase substrate specificity in vitro and in vivo: control of glycogen biosynthesis by Pcl8 and Pcl10. Molecular and Cellular Biology. 18: 3289-99. PMID 9584169 DOI: 10.1128/Mcb.18.6.3289 |
0.596 |
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