Karsten Sauer, PhD - Publications

Immunology and Microbial Science Scripps Research Institute, La Jolla, La Jolla, CA, United States 

44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Lin X, Pelletier S, Gingras S, Rigaud S, Maine CJ, Marquardt K, Dai YD, Sauer K, Rodriguez AR, Martin G, Kupriyanov S, Jiang L, Yu L, Green DR, Sherman LA. CRISPR-Cas9 mediated modification of the NOD mouse genome with Ptpn22R619W mutation increases autoimmune diabetes. Diabetes. PMID 27207523 DOI: 10.2337/db16-0061  1
2016 Westernberg L, Conche C, Huang YH, Rigaud S, Deng Y, Siegemund S, Mukherjee S, Nosaka L, Das J, Sauer K. Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent. Elife. 5. PMID 26880557 DOI: 10.7554/eLife.10786  1
2015 Sauer K, Okkenhaug K. Editorial: Lipid Signaling in T Cell Development and Function. Frontiers in Immunology. 6: 410. PMID 26322043 DOI: 10.3389/fimmu.2015.00410  1
2015 Lawson BR, Gonzalez-Quintial R, Eleftheriadis T, Farrar MA, Miller SD, Sauer K, McGavern DB, Kono DH, Baccala R, Theofilopoulos AN. Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation. Clinical Immunology (Orlando, Fla.). 161: 260-269. PMID 26319414 DOI: 10.1016/j.clim.2015.08.007  1
2015 Siegemund S, Shepherd J, Xiao C, Sauer K. hCD2-iCre and Vav-iCre mediated gene recombination patterns in murine hematopoietic cells. Plos One. 10: e0124661. PMID 25884630 DOI: 10.1371/journal.pone.0124661  1
2015 Siegemund S, Rigaud S, Conche C, Broaten B, Schaffer L, Westernberg L, Head SR, Sauer K. IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice. Blood. 125: 2786-97. PMID 25788703 DOI: 10.1182/blood-2014-06-583187  1
2015 Rigaud S, Sauer K. IP3 3-kinase B prevents bone marrow failure Oncotarget. 6: 15706-15707.  1
2014 Rybakin V, Westernberg L, Fu G, Kim HO, Ampudia J, Sauer K, Gascoigne NR. Allelic exclusion of TCR α-chains upon severe restriction of Vα repertoire. Plos One. 9: e114320. PMID 25500569 DOI: 10.1371/journal.pone.0114320  1
2014 Xu X, Jaeger ER, Wang X, Lagler-Ferrez E, Batalov S, Mathis NL, Wiltshire T, Walker JR, Cooke MP, Sauer K, Huang YH. Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration. Plos One. 9: e105561. PMID 25133611 DOI: 10.1371/journal.pone.0105561  1
2014 Conche C, Sauer K. Uncovering the PI3Ksome: phosphoinositide 3-kinases and counteracting PTEN form a signaling complex with intrinsic regulatory properties. Molecular and Cellular Biology. 34: 3356-8. PMID 25047838 DOI: 10.1128/MCB.00920-14  1
2013 Fu G, Casas J, Rigaud S, Rybakin V, Lambolez F, Brzostek J, Hoerter JA, Paster W, Acuto O, Cheroutre H, Sauer K, Gascoigne NR. Themis sets the signal threshold for positive and negative selection in T-cell development. Nature. 504: 441-5. PMID 24226767 DOI: 10.1038/nature12718  1
2013 Mukherjee S, Rigaud S, Seok SC, Fu G, Prochenka A, Dworkin M, Gascoigne NR, Vieland VJ, Sauer K, Das J. In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness. Plos One. 8: e73937. PMID 24066087 DOI: 10.1371/journal.pone.0073937  1
2013 Sauer K, Park E, Siegemund S, French AR, Wahle JA, Sternberg L, Rigaud S, Jonsson AH, Yokoyama WM, Huang YH. Inositol tetrakisphosphate limits NK cell effector functions by controlling PI3K signaling. Blood. 121: 286-97. PMID 23175687 DOI: 10.1182/blood-2012-05-429241  1
2012 Siegemund S, Sauer K. Balancing pro- and anti-inflammatory TLR4 signaling. Nature Immunology. 13: 1031-3. PMID 23080196 DOI: 10.1038/ni.2452  1
2012 Hirve N, Levytskyy RM, Rigaud S, Guimond DM, Zal T, Sauer K, Tsoukas CD. A conserved motif in the ITK PH-domain is required for phosphoinositide binding and TCR signaling but dispensable for adaptor protein interactions. Plos One. 7: e45158. PMID 23028816 DOI: 10.1371/journal.pone.0045158  1
2011 Fu G, Hu J, Niederberger-Magnenat N, Rybakin V, Casas J, Yachi PP, Feldstein S, Ma B, Hoerter JA, Ampudia J, Rigaud S, Lambolez F, Gavin AL, Sauer K, Cheroutre H, et al. Protein kinase C η is required for T cell activation and homeostatic proliferation. Science Signaling. 4: ra84. PMID 22155788 DOI: 10.1126/scisignal.2002058  1
2011 Barouch-Bentov R, Sauer K. Mechanisms of drug resistance in kinases. Expert Opinion On Investigational Drugs. 20: 153-208. PMID 21235428 DOI: 10.1517/13543784.2011.546344  1
2010 Huang YH, Sauer K. Lipid signaling in T-cell development and function. Cold Spring Harbor Perspectives in Biology. 2: a002428. PMID 20943760 DOI: 10.1101/cshperspect.a002428  1
2010 Sauer K, Cooke MP. Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate. Nature Reviews. Immunology. 10: 257-71. PMID 20336153 DOI: 10.1038/nri2745  1
2010 Poderycki M, Tomimori Y, Ando T, Xiao W, Maeda-Yamamoto M, Sauer K, Kawakami Y, Kawakami T. A minor catalytic activity of Src family kinases is sufficient for maximal activation of mast cells via the high-affinity IgE receptor. Journal of Immunology (Baltimore, Md. : 1950). 184: 84-93. PMID 19949072 DOI: 10.4049/jimmunol.0901590  1
2009 Sauer K, Huang YH, Lin H, Sandberg M, Mayr GW. Phosphoinositide and inositol phosphate analysis in lymphocyte activation. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit11.1. PMID 19918943 DOI: 10.1002/0471142735.im1101s87  1
2009 Lenox LE, Kambayashi T, Okumura M, Prieto C, Sauer K, Bunte RM, Jordan MS, Koretzky GA, Nichols KE. Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis. The Journal of Allergy and Clinical Immunology. 124: 1088-98. PMID 19895996 DOI: 10.1016/j.jaci.2009.08.038  1
2009 Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga EI. Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity. 31: 145-57. PMID 19604493 DOI: 10.1016/j.immuni.2009.06.015  1
2009 Fu G, Vallée S, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, Salek M, Fallen PR, Hoerter JA, Munshi A, Huang YH, Hu J, Fox HS, Sauer K, Acuto O, et al. Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nature Immunology. 10: 848-56. PMID 19597499 DOI: 10.1038/ni.1766  1
2009 Elsaesser H, Sauer K, Brooks DG. IL-21 is required to control chronic viral infection. Science (New York, N.Y.). 324: 1569-72. PMID 19423777 DOI: 10.1126/science.1174182  1
2009 Barouch-Bentov R, Che J, Lee CC, Yang Y, Herman A, Jia Y, Velentza A, Watson J, Sternberg L, Kim S, Ziaee N, Miller A, Jackson C, Fujimoto M, Young M, ... ... Sauer K, et al. A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function. Molecular Cell. 33: 43-52. PMID 19150426 DOI: 10.1016/j.molcel.2008.12.024  1
2008 Huang YH, Hoebe K, Sauer K. New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B. Expert Opinion On Therapeutic Targets. 12: 391-413. PMID 18348677 DOI: 10.1517/14728222.12.4.391  1
2007 Miller AT, Sandberg M, Huang YH, Young M, Sutton S, Sauer K, Cooke MP. Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation. Nature Immunology. 8: 514-21. PMID 17417640 DOI: 10.1038/ni1458  1
2007 Huang YH, Grasis JA, Miller AT, Xu R, Soonthornvacharin S, Andreotti AH, Tsoukas CD, Cooke MP, Sauer K. Positive regulation of Itk PH domain function by soluble IP4. Science (New York, N.Y.). 316: 886-9. PMID 17412921 DOI: 10.1126/science.1138684  1
2006 Huang YH, Barouch-Bentov R, Herman A, Walker J, Sauer K. Integrating traditional and postgenomic approaches to investigate lymphocyte development and function. Advances in Experimental Medicine and Biology. 584: 245-76. PMID 16802612 DOI: 10.1007/0-387-34132-3_18  1
2005 Chamberlain PP, Sandberg ML, Sauer K, Cooke MP, Lesley SA, Spraggon G. Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B. Biochemistry. 44: 14486-93. PMID 16262249 DOI: 10.1021/bi051256q  1
2004 Wen BG, Pletcher MT, Warashina M, Choe SH, Ziaee N, Wiltshire T, Sauer K, Cooke MP. Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity. Proceedings of the National Academy of Sciences of the United States of America. 101: 5604-9. PMID 15064401 DOI: 10.1073/pnas.0306907101  1
2003 Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC. Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 100: 443-8. PMID 12522270 DOI: 10.1073/pnas.2436191100  1
2003 Takaki S, Tezuka Y, Sauer K, Kubo C, Kwon SM, Armstead E, Nakao K, Katsuki M, Perlmutter RM, Takatsu K. Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor protein. Journal of Immunology (Baltimore, Md. : 1950). 170: 703-10. PMID 12517931  1
2001 Sauer K, Liou J, Singh SB, Yablonski D, Weiss A, Perlmutter RM. Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes. The Journal of Biological Chemistry. 276: 45207-16. PMID 11487585 DOI: 10.1074/jbc.M106811200  1
2001 Lehner CF, Jacobs HW, Sauer K, Meyer CA. Regulation of the embryonic cell proliferation by Drosophila cyclin D and cyclin E complexes. Novartis Foundation Symposium. 237: 43-54; discussion 54. PMID 11444049  1
2000 Takaki S, Sauer K, Iritani BM, Chien S, Ebihara Y, Tsuji Ki, Takatsu K, Perlmutter RM. Control of B cell production by the adaptor protein Lnk: Definition of a conserved family of signal-modulating proteins Immunity. 13: 599-609. PMID 11114373  1
1998 Farrar MA, Doerfler P, Sauer K. Signal transduction pathways regulating the development of αβ T cells Biochimica Et Biophysica Acta - Reviews On Cancer. 1377: F35-F78. PMID 9659403 DOI: 10.1016/S0304-419X(97)00038-3  1
1996 Lane ME, Sauer K, Wallace K, Jan YN, Lehner CF, Vaessin H. Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell. 87: 1225-35. PMID 8980229 DOI: 10.1016/S0092-8674(00)81818-8  1
1996 Sauer K, Weigmann K, Sigrist S, Lehner CF. Novel members of the cdc2-related kinase family in Drosophila: cdk4/6, cdk5, PFTAIRE, and PITSLRE kinase. Molecular Biology of the Cell. 7: 1759-69. PMID 8930898  1
1995 Sauer K, Lehner CF. The role of cyclin E in the regulation of entry into S phase. Progress in Cell Cycle Research. 1: 125-39. PMID 9552358  1
1995 Sauer K, Knoblich JA, Richardson H, Lehner CF. Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis. Genes & Development. 9: 1327-39. PMID 7797073  1
1994 Knoblich JA, Sauer K, Jones L, Richardson H, Saint R, Lehner CF. Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Cell. 77: 107-20. PMID 8156587 DOI: 10.1016/0092-8674(94)90239-9  1
1991 Green SR, Fullekrug J, Sauer K, Tuite MF. Isolation and characterisation of a bovine cDNA encoding eukaryotic initiation factor 2 alpha. Biochimica Et Biophysica Acta. 1090: 277-80. PMID 1932125 DOI: 10.1016/0167-4781(91)90119-7  1
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