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Christopher J. Thibodeaux - Publications

Affiliations: 
2016- Chemistry McGill University, Montreal, QC, Canada 
Area:
biochemistry, biophysics, biosynthesis, natural products, post-translational modification
Website:
http://www.thibodeauxlab.com/
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Du C, Woolcott S, Wahba AS, Hamry SR, Odette WL, Thibodeaux CJ, Marchand P, Mauzeroll J. Evaluation of Quatsome Morphology, Composition, and Stability for Biofilm Eradication. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 38194503 DOI: 10.1021/acs.langmuir.3c02491  0.739
2023 Wang G, Venegas F, Rueda A, Weerasinghe N, Uggowitzer KA, Thibodeaux CJ, Moitessier N, Mittermaier AK. A naturally occurring G11S mutation in the 3C-like protease from the SARS-CoV-2 virus dramatically weakens the dimer interface. Protein Science : a Publication of the Protein Society. e4857. PMID 38058248 DOI: 10.1002/pro.4857  0.747
2023 Thibodeaux CJ. The conformationally dynamic structural biology of lanthipeptide biosynthesis. Current Opinion in Structural Biology. 81: 102644. PMID 37352604 DOI: 10.1016/j.sbi.2023.102644  0.484
2023 Lemay-St-Denis C, Alejaldre L, Jemouai Z, Lafontaine K, St-Aubin M, Hitache K, Valikhani D, Weerasinghe NW, Létourneau M, Thibodeaux CJ, Doucet N, Baron C, Copp JN, Pelletier JN. A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 378: 20220040. PMID 36633286 DOI: 10.1098/rstb.2022.0040  0.761
2022 Saran A, Weerasinghe N, Thibodeaux CJ, Zeytuni N. Purification, crystallization and crystallographic analysis of the PorX response regulator associated with the type IX secretion system. Acta Crystallographica. Section F, Structural Biology Communications. 78: 354-362. PMID 36189719 DOI: 10.1107/S2053230X22008500  0.689
2022 Uggowitzer KA, Shao ARQ, Habibi Y, Zhang QE, Thibodeaux CJ. Exploring the Heterogeneous Structural Dynamics of Class II Lanthipeptide Synthetases with Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS). Biochemistry. PMID 36094889 DOI: 10.1021/acs.biochem.2c00360  0.792
2022 Habibi Y, Weerasinghe NW, Uggowitzer KA, Thibodeaux CJ. Partially Modified Peptide Intermediates in Lanthipeptide Biosynthesis Alter the Structure and Dynamics of a Lanthipeptide Synthetase. Journal of the American Chemical Society. 144: 10230-10240. PMID 35647706 DOI: 10.1021/jacs.2c00727  0.802
2021 Ducharme J, Sevrioukova IF, Thibodeaux CJ, Auclair K. Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reductase. Biochemistry. PMID 34196520 DOI: 10.1021/acs.biochem.1c00178  0.357
2021 Ducharme J, Polic V, Thibodeaux CJ, Auclair K. Combining Small-Molecule Bioconjugation and Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) to Expose Allostery: the Case of Human Cytochrome P450 3A4. Acs Chemical Biology. 16: 882-890. PMID 33913317 DOI: 10.1021/acschembio.1c00084  0.324
2021 Weerasinghe NW, Habibi Y, Uggowitzer KA, Thibodeaux CJ. Exploring the Conformational Landscape of a Lanthipeptide Synthetase Using Native Mass Spectrometry. Biochemistry. 60: 1506-1519. PMID 33887902 DOI: 10.1021/acs.biochem.1c00085  0.809
2021 Uggowitzer KA, Habibi Y, Wei W, Moitessier N, Thibodeaux CJ. Mutations in Dynamic Structural Elements Alter the Kinetics and Fidelity of the Multifunctional Class II Lanthipeptide Synthetase, HalM2. Biochemistry. PMID 33507068 DOI: 10.1021/acs.biochem.0c00919  0.822
2020 Habibi Y, Thibodeaux CJ. A Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) Platform for Investigating Peptide Biosynthetic Enzymes. Journal of Visualized Experiments : Jove. PMID 32420996 DOI: 10.3791/61053  0.773
2019 Habibi Y, Uggowitzer KA, Issak H, Thibodeaux CJ. Insights into the Dynamic Structural Properties of a Lanthipeptide Synthetase using Hydrogen-Deuterium Exchange Mass Spectrometry. Journal of the American Chemical Society. PMID 31449409 DOI: 10.1021/jacs.9b06020  0.724
2019 Thibodeaux CJ, Chang WC, Liu HW. Unraveling flavoenzyme reaction mechanisms using flavin analogues and linear free energy relationships. Methods in Enzymology. 620: 167-188. PMID 31072486 DOI: 10.1016/Bs.Mie.2019.03.010  0.543
2017 Thibodeaux CJ, Liu HW. The type II isopentenyl Diphosphate:Dimethylallyl diphosphate isomerase (IDI-2): A model for acid/base chemistry in flavoenzyme catalysis. Archives of Biochemistry and Biophysics. PMID 28577910 DOI: 10.1016/J.Abb.2017.05.017  0.595
2016 Thibodeaux CJ, Wagoner J, Yu Y, van der Donk WA. The Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis. Journal of the American Chemical Society. PMID 27123925 DOI: 10.1021/Jacs.6B00163  0.644
2015 Ju KS, Gao J, Doroghazi JR, Wang KA, Thibodeaux CJ, Li S, Metzger E, Fudala J, Su J, Zhang JK, Lee J, Cioni JP, Evans BS, Hirota R, Labeda DP, et al. Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes. Proceedings of the National Academy of Sciences of the United States of America. PMID 26324907 DOI: 10.1073/Pnas.1500873112  0.527
2014 Thibodeaux CJ, Ha T, van der Donk WA. A price to pay for relaxed substrate specificity: a comparative kinetic analysis of the class II lanthipeptide synthetases ProcM and HalM2. Journal of the American Chemical Society. 136: 17513-29. PMID 25409537 DOI: 10.1021/Ja5089452  0.69
2012 Thibodeaux CJ, Van Der Donk WA. Converging on a mechanism for choline degradation Proceedings of the National Academy of Sciences of the United States of America. 109: 21184-21185. PMID 23243142 DOI: 10.1073/Pnas.1219534110  0.59
2012 Sun HG, Ruszczycky MW, Chang WC, Thibodeaux CJ, Liu HW. Nucleophilic participation of reduced flavin coenzyme in mechanism of UDP-galactopyranose mutase. The Journal of Biological Chemistry. 287: 4602-8. PMID 22187430 DOI: 10.1074/Jbc.M111.312538  0.556
2012 Calveras J, Thibodeaux CJ, Mansoorabadi SO, Liu HW. Stereochemical studies of the type II isopentenyl diphosphate-dimethylallyl diphosphate isomerase implicate the FMN coenzyme in substrate protonation. Chembiochem : a European Journal of Chemical Biology. 13: 42-6. PMID 22135039 DOI: 10.1002/Cbic.201100694  0.793
2012 Thibodeaux CJ, Chang WC, Liu HW. Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis. Chemical Reviews. 112: 1681-709. PMID 22017381 DOI: 10.1021/Cr200073D  0.603
2011 Thibodeaux CJ, Liu HW. Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: characterization of an unusual pyridoxal 5'-phosphate-dependent reaction. Biochemistry. 50: 1950-62. PMID 21244019 DOI: 10.1021/Bi101927S  0.634
2010 Thibodeaux CJ, Chang WC, Liu HW. Linear free energy relationships demonstrate a catalytic role for the flavin mononucleotide coenzyme of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase. Journal of the American Chemical Society. 132: 9994-6. PMID 20593767 DOI: 10.1021/Ja104090M  0.622
2009 White-Phillip J, Thibodeaux CJ, Liu HW. Enzymatic synthesis of TDP-deoxysugars. Methods in Enzymology. 459: 521-44. PMID 19362653 DOI: 10.1016/S0076-6879(09)04621-7  0.63
2009 Thibodeaux CJ, Liu H. Unraveling the Mechanisms of Isoprenoid Biosynthetic Enzymes: Mechanistic Studies of the Early Stage Enzymes Chimia International Journal For Chemistry. 63: 334-339. DOI: 10.2533/Chimia.2009.334  0.463
2008 Thibodeaux CJ, Melançon CE, Liu HW. Natural-product sugar biosynthesis and enzymatic glycodiversification. Angewandte Chemie (International Ed. in English). 47: 9814-59. PMID 19058170 DOI: 10.1002/Anie.200801204  0.805
2008 Thibodeaux CJ, Mansoorabadi SO, Kittleman W, Chang WC, Liu HW. Evidence for the involvement of acid/base chemistry in the reaction catalyzed by the type II isopentenyl diphosphate/dimethylallyl diphosphate isomerase from Staphylococcus aureus. Biochemistry. 47: 2547-58. PMID 18229948 DOI: 10.1021/Bi701467G  0.773
2008 Thibodeaux C, Melançon C, Liu H. Biosynthese von Naturstoffzuckern und enzymatische Glycodiversifizierung Angewandte Chemie. 120: 9960-10007. DOI: 10.1002/Ange.200801204  0.74
2007 Kittleman W, Thibodeaux CJ, Liu YN, Zhang H, Liu HW. Characterization and mechanistic studies of type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Staphylococcus aureus. Biochemistry. 46: 8401-13. PMID 17585782 DOI: 10.1021/Bi700286A  0.649
2007 Mansoorabadi SO, Thibodeaux CJ, Liu HW. The diverse roles of flavin coenzymes--nature's most versatile thespians. The Journal of Organic Chemistry. 72: 6329-42. PMID 17580897 DOI: 10.1021/Jo0703092  0.789
2007 Thibodeaux CJ, Melançon CE, Liu HW. Unusual sugar biosynthesis and natural product glycodiversification. Nature. 446: 1008-16. PMID 17460661 DOI: 10.1038/Nature05814  0.801
2007 Thibodeaux CJ, Liu H. Manipulating nature's sugar biosynthetic machineries for glycodiversification of macrolides: Recent advances and future prospects Pure and Applied Chemistry. 79: 785-799. DOI: 10.1351/Pac200779040785  0.579
2007 Mansoorabadi S, Thibodeaux CJ, Liu H. The Diverse Roles of Flavin Coenzymes — Nature′s Most Versatile Thespians Cheminform. 38. DOI: 10.1002/CHIN.200748273  0.683
2006 Melançon CE, Thibodeaux CJ, Liu HW. Glyco-stripping and glyco-swapping. Acs Chemical Biology. 1: 499-504. PMID 17168536 DOI: 10.1021/Cb600365Q  0.791
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