Samantha Harris - Publications

Affiliations: 
University of Washington, Seattle, Seattle, WA 
Area:
General Biophysics, Biochemistry, Biomedical Engineering

75 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Hessel AL, Engels NM, Kuehn MN, Nissen D, Sadler RL, Ma W, Irving TC, Linke WA, Harris SP. Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads. Nature Communications. 15: 2628. PMID 38521794 DOI: 10.1038/s41467-024-46957-7  0.579
2023 Hessel AL, Engels NM, Kuehn M, Nissen D, Sadler RL, Ma W, Irving TC, Linke WA, Harris SP. Myosin-binding protein C forms C-links and stabilizes OFF states of myosin. Biorxiv : the Preprint Server For Biology. PMID 37745361 DOI: 10.1101/2023.09.10.556972  0.642
2022 Risi CM, Villanueva E, Belknap B, Sadler RL, Harris SP, White HD, Galkin VE. Cryo-Electron Microscopy Reveals Cardiac Myosin Binding Protein-C M-Domain Interactions with the Thin Filament. Journal of Molecular Biology. 434: 167879. PMID 36370805 DOI: 10.1016/j.jmb.2022.167879  0.671
2021 Risi CM, Patra M, Belknap B, Harris SP, White HD, Galkin VE. Interaction of the C2 Ig-like Domain of Cardiac Myosin Binding Protein-C with F-actin. Journal of Molecular Biology. 167178. PMID 34329643 DOI: 10.1016/j.jmb.2021.167178  0.683
2021 Harris SP. Making waves: A proposed new role for myosin-binding protein C in regulating oscillatory contractions in vertebrate striated muscle. The Journal of General Physiology. 153. PMID 33275758 DOI: 10.1085/jgp.202012729  0.39
2020 Napierski NC, Granger K, Langlais PR, Moran HR, Strom J, Youssef KD, Harris SP. A Novel "Cut And Paste" Method for In Situ Replacement of cMyBP-C Reveals a New Role for cMyBP-C in the Regulation of Contractile Oscillations. Circulation Research. PMID 32078438 DOI: 10.1161/CIRCRESAHA.119.315760  0.614
2020 Napierski NC, Granger K, Harris SP. Selective Phosphorylation of cMyBP-C Increases Cross-Bridge Cycling Rates in Permeabilized Cardiomyocytes From SPY-C Mice Biophysical Journal. 118: 591a-592a. DOI: 10.1016/j.bpj.2019.11.3204  0.412
2019 Risi C, Belknap B, Harris S, White H, Galkin VE. C0 Ig-Domain of Cardiac Myosin Binding Protein-C Interacts with the Regulatory Light Chain of Myosin-S1 Bound to the Native Cardiac Thin Filament Biophysical Journal. 116: 116a-117a. DOI: 10.1016/J.Bpj.2018.11.655  0.651
2019 Harris SP. Acute Loss of cMyBP-C Induces Auto-Oscillatory Contractions in Permeabilized Cardiomyocytes: Implications for Reverse E-C Coupling? Biophysical Journal. 116: 461a-462a. DOI: 10.1016/j.bpj.2018.11.2493  0.393
2018 Risi C, Belknap B, Forgacs-Lonart E, Harris SP, Schröder GF, White HD, Galkin VE. N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament. Structure (London, England : 1993). PMID 30270174 DOI: 10.1016/j.str.2018.08.007  0.672
2018 van Dijk SJ, Kooiker KB, Napierski NC, Touma KD, Mazzalupo S, Harris SP. Point mutations in the tri-helix bundle of the M-domain of cardiac myosin binding protein-C influence systolic duration and delay cardiac relaxation. Journal of Molecular and Cellular Cardiology. PMID 29729251 DOI: 10.1016/J.Yjmcc.2018.05.001  0.656
2018 Risi C, Belknap B, Glendrange T, Harris S, White HD, Schröder G, Galkin VE. C1 IG-Domain of Myosin Binding Protein-C Activates Cardiac Thin Filament by Means of Thethering Tropomyosin to the Subdomain-1 of Actin Biophysical Journal. 114: 145a-146a. DOI: 10.1016/J.Bpj.2017.11.817  0.719
2018 Touma K, van Dijk SJ, Strom J, Harris SP. In Situ Replacement of cMyBP-C N'-Terminal Domains using the Novel Spy-C Method Biophysical Journal. 114: 549a-550a. DOI: 10.1016/j.bpj.2017.11.3002  0.499
2017 McNamara JW, Li A, Lal S, Bos JM, Harris SP, van der Velden J, Ackerman MJ, Cooke R, Dos Remedios CG. MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy. Plos One. 12: e0180064. PMID 28658286 DOI: 10.1371/journal.pone.0180064  0.414
2017 Eisner J, Risi C, Virok B, Kovacs J, Harris SP, Wriggers WR, White HD, Galkin VE. C0 Domain of Cardiac Myosin Binding Protein-C Modulates Interaction of the Neighboring C1 Domain with Tropomyosin Through the Allosteric Interaction with F-Actin Biophysical Journal. 112: 561a. DOI: 10.1016/j.bpj.2016.11.3023  0.642
2017 van Dijk SJ, Strom J, Harris SP. Reduced Binding of the M-Domain of Cardiac Myosin Binding Protein C to Actin Impairs the Ability of the Heart to Respond to Chronic Stress Biophysical Journal. 112: 557a. DOI: 10.1016/j.bpj.2016.11.3004  0.513
2017 Virok B, Harris S, Galkin VE, White HD. Activation and Inhibition of Cardiac Thin Filaments by Single and Multiple Domains Constructs of Human Cardiac Myosin Binding Protein-C (cMyBP-C) at Low Calcium Biophysical Journal. 112: 257a-258a. DOI: 10.1016/J.Bpj.2016.11.1402  0.675
2016 Kolb J, Li F, Methawasin M, Adler M, Escobar YN, Nedrud J, Pappas CT, Harris SP, Granzier H. Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin. Journal of Molecular and Cellular Cardiology. PMID 27139341 DOI: 10.1016/J.Yjmcc.2016.04.013  0.365
2016 McNamara JW, Li A, Smith NJ, Lal S, Graham RM, Kooiker KB, van Dijk SJ, Remedios CG, Harris SP, Cooke R. Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes. Journal of Molecular and Cellular Cardiology. PMID 27021517 DOI: 10.1016/j.yjmcc.2016.03.009  0.585
2016 Harris SP, Belknap B, Van Sciver RE, White HD, Galkin VE. C0 and C1 N-terminal Ig domains of myosin binding protein C exert different effects on thin filament activation. Proceedings of the National Academy of Sciences of the United States of America. 113: 1558-63. PMID 26831109 DOI: 10.1073/pnas.1518891113  0.687
2016 van Dijk SJ, Kooiker KB, Mazzalupo S, Yang Y, Kostyukova AS, Mustacich DJ, Hoye ER, Stern JA, Kittleson MD, Harris SP. The A31P missense mutation in cardiac myosin binding protein C alters protein structure but does not cause haploinsufficiency. Archives of Biochemistry and Biophysics. PMID 26777460 DOI: 10.1016/J.Abb.2016.01.006  0.529
2016 Harris SP, Belknap B, Van Sciver RE, White HD, Galkin VE. C0 and C1 N-terminal Ig domains of myosin binding protein C exert different effects on thin filament activation Proceedings of the National Academy of Sciences of the United States of America. 113: 1558-1563. DOI: 10.1073/pnas.1518891113  0.67
2016 McNamara JW, Li A, Lal S, Bos JM, Ackerman MJ, dos Remedios CG, Harris SP, Cooke R. Regulation of the Super-Relaxed State of Myosin by Cardiac Myosin Binding Protein-C Biophysical Journal. 110: 293a. DOI: 10.1016/j.bpj.2015.11.1585  0.55
2015 Kittleson MD, Meurs KM, Harris SP. The genetic basis of hypertrophic cardiomyopathy in cats and humans. Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology. 17: S53-73. PMID 26776594 DOI: 10.1016/j.jvc.2015.03.001  0.354
2015 Mun JY, Kensler RW, Harris SP, Craig R. The cMyBP-C HCM variant L348P enhances thin filament activation through an increased shift in tropomyosin position. Journal of Molecular and Cellular Cardiology. 91: 141-147. PMID 26718724 DOI: 10.1016/J.Yjmcc.2015.12.014  0.539
2015 van Dijk SJ, Witt CC, Harris SP. Normal cardiac contraction in mice lacking the proline-alanine rich region and C1 domain of cardiac myosin binding protein C. Journal of Molecular and Cellular Cardiology. 88: 124-132. PMID 26455481 DOI: 10.1016/j.yjmcc.2015.09.006  0.53
2015 Walcott S, Docken S, Harris SP. Effects of cardiac Myosin binding protein-C on actin motility are explained with a drag-activation-competition model. Biophysical Journal. 108: 10-3. PMID 25564844 DOI: 10.1016/j.bpj.2014.11.1852  0.606
2015 Lee K, Harris SP, Sadayappan S, Craig R. Orientation of myosin binding protein C in the cardiac muscle sarcomere determined by domain-specific immuno-EM. Journal of Molecular Biology. 427: 274-86. PMID 25451032 DOI: 10.1016/J.Jmb.2014.10.023  0.651
2015 Mun JY, Kensler RW, Harris SP, Craig R. The HCM Mutation L348P in cMyBP-C Enhances Thin Filament Activation through Tropomyosin Shift Biophysical Journal. 108: 133a. DOI: 10.1016/J.Bpj.2014.11.738  0.513
2015 van Dijk SJ, Bezold KL, Harris SP. The Physiological Relevance of Interactions between cMyBP-C and Actin Studied in a Transgenic Mouse Model Biophysical Journal. 108: 133a. DOI: 10.1016/j.bpj.2014.11.737  0.436
2015 Harris S, Virok B, White H, Galkin VE. Three Dimensional Reconstruction of the Native Cardiac Thin Filament Decorated with Myosin-Binding Protein C Fragment: Implications for Cardiac Regulation Biophysical Journal. 108: 508a. DOI: 10.1016/J.Bpj.2014.11.2783  0.735
2015 van Dijk SJ, Bezold KL, Mazzalupo S, Kittleson MD, Kostyukova AS, Harris SP. The A31P Hcm Mutation in cMyBP-C Disrupts the Structure of the C0 Domain But Does Not Cause Haploinsufficiency in a Population of Older Cats Heterozygous for the A31P Allele Biophysical Journal. 108: 200a-201a. DOI: 10.1016/J.Bpj.2014.11.1109  0.55
2014 Belknap B, Harris SP, White HD. Modulation of thin filament activation of myosin ATP hydrolysis by N-terminal domains of cardiac myosin binding protein-C. Biochemistry. 53: 6717-24. PMID 25265574 DOI: 10.1021/bi500787f  0.553
2014 Chow ML, Shaffer JF, Harris SP, Dawson JF. Altered interactions between cardiac myosin binding protein-C and α-cardiac actin variants associated with cardiomyopathies. Archives of Biochemistry and Biophysics. 550: 28-32. PMID 24736382 DOI: 10.1016/J.Abb.2014.04.003  0.804
2014 van Dijk SJ, Bezold KL, Harris SP. Earning stripes: myosin binding protein-C interactions with actin. Pflã¼Gers Archiv : European Journal of Physiology. 466: 445-50. PMID 24442149 DOI: 10.1007/s00424-013-1432-8  0.643
2014 Bezold KL, Khosa JK, Harris SP. A Gain-Of-Function Mutation in Cardiac Myosin Binding Protein-C Increases Viscoelastic Load and Slows Shortening Velocity in Myocytes from Transgenic Mice Biophysical Journal. 106: 346a. DOI: 10.1016/J.BPJ.2013.11.1973  0.426
2013 Bezold KL, Shaffer JF, Khosa JK, Hoye ER, Harris SP. A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin Journal of Biological Chemistry. 288: 21496-21505. PMID 23782699 DOI: 10.1074/Jbc.M113.474346  0.808
2013 Karsai Á, Kellermayer MS, Harris SP. Cross-species mechanical fingerprinting of cardiac myosin binding protein-C. Biophysical Journal. 104: 2465-75. PMID 23746519 DOI: 10.1016/j.bpj.2013.04.027  0.549
2013 White HD, Belknap B, Harris SP. Activation and Inhibition of F-Actin and Cardiac Thin Filaments by the N-Terminal Domains of Cardiac Myosin Binding Protein C Biophysical Journal. 104: 158a-159a. DOI: 10.1016/J.BPJ.2012.11.893  0.549
2013 Harris SP, Hoye E. Calcium-Calmodulin Competes with Actin for Binding to the M-Domain of Cardiac Myosin Binding Protein-C Biophysical Journal. 104: 313a. DOI: 10.1016/j.bpj.2012.11.1735  0.54
2013 Lee K, Sadayappan S, Harris S, Craig R. Determination of MyBP-C Orientation in the Cardiac Sarcomere by Immuno-EM Biophysical Journal. 104: 309a. DOI: 10.1016/J.Bpj.2012.11.1716  0.625
2013 Bezold KL, Khosa JK, Harris SP. Helix Three (H3) of the M-Domain of Cardiac Myosin Binding Protein-C is not Essential for Functional Effects in Permeabilized Rat Trabeculae Biophysical Journal. 104: 186a. DOI: 10.1016/j.bpj.2012.11.1053  0.511
2012 Harris S. Dynamic Regulation of Contraction by Cardiac Myosin Binding Protein-C Biophysical Journal. 102: 598a. DOI: 10.1016/J.Bpj.2011.11.3255  0.668
2012 Karsai A, Kellermayer MS, Harris SP. Common Mechanical Properties of Recombinant and Native Cardiac Myosin Binding Protein-C by Atomic Force Microscope Biophysical Journal. 102: 558a. DOI: 10.1016/j.bpj.2011.11.3040  0.454
2012 Bezold KL, Harris SP. Effects of HCM Missense Mutations in the M Domain of Cardiac Myosin Binding Protein C on Calcium Sensitivity of Force and Rate in Rat Trabeculae Biophysical Journal. 102: 558a. DOI: 10.1016/j.bpj.2011.11.3039  0.462
2012 White HD, Harris S. Activation of Cardiac Thin Filaments by N-Terminal Domains of Cardiac Myosin Binding Protein C Biophysical Journal. 102: 435a. DOI: 10.1016/J.Bpj.2011.11.2382  0.62
2011 Karsai A, Kellermayer MS, Harris SP. Mechanical unfolding of cardiac myosin binding protein-C by atomic force microscopy. Biophysical Journal. 101: 1968-77. PMID 22004751 DOI: 10.1016/j.bpj.2011.08.030  0.623
2011 Harris SP, Lyons RG, Bezold KL. In the thick of it: HCM-causing mutations in myosin binding proteins of the thick filament. Circulation Research. 108: 751-64. PMID 21415409 DOI: 10.1161/CIRCRESAHA.110.231670  0.41
2011 Kensler RW, Shaffer JF, Harris SP. Binding of the N-terminal fragment C0-C2 of cardiac MyBP-C to cardiac F-actin. Journal of Structural Biology. 174: 44-51. PMID 21163356 DOI: 10.1016/J.Jsb.2010.12.003  0.804
2011 Bezold KL, Harris SP. Charged Amino Acids in the N-Terminus of Cardiac Myosin Binding Protein-C Contribute to Contractile Effects in Permeabilized Myocytes Biophysical Journal. 100: 454a. DOI: 10.1016/j.bpj.2010.12.2674  0.497
2011 Karsai A, Harris SP, Kellermayer M. The Motif of Myosin Binding Protein-C is Mechanically Weak and Extensible Biophysical Journal. 100: 453a-454a. DOI: 10.1016/J.Bpj.2010.12.2672  0.47
2010 Shaffer JF, Wong P, Bezold KL, Harris SP. Functional differences between the N-terminal domains of mouse and human myosin binding protein-C. Journal of Biomedicine & Biotechnology. 2010: 789798. PMID 20379391 DOI: 10.1155/2010/789798  0.794
2010 Jia W, Shaffer JF, Harris SP, Leary JA. Identification of novel protein kinase A phosphorylation sites in the M-domain of human and murine cardiac myosin binding protein-C using mass spectrometry analysis. Journal of Proteome Research. 9: 1843-53. PMID 20151718 DOI: 10.1021/Pr901006H  0.808
2010 Shaffer JF, Harris SP. Identification of Amino Acid Residues in the Cardiac Myosin Binding Protein-C Motif Important for Actin Binding Biophysical Journal. 98: 756a. DOI: 10.1016/J.Bpj.2009.12.4150  0.804
2010 Shaffer JF, Wong P, Bezold KL, Harris SP. Comparative Effects of the Proline-Alanine Rich Regions of Human and Murine Cardiac Myosin Binding Protein-C Biophysical Journal. 98: 555a. DOI: 10.1016/J.Bpj.2009.12.3003  0.768
2010 Bezold KL, Hoye E, Shaffer J, Gomes A, Kittleson M, Harris S. Incorporation of the A31P Cardiac Myosin Binding Protein C Missense Mutation Into Feline Cardiac Sarcomeres Biophysical Journal. 98: 554a. DOI: 10.1016/J.Bpj.2009.12.2999  0.758
2009 Shaffer JF, Harris SP. Species-specific differences in the Pro-Ala rich region of cardiac myosin binding protein-C. Journal of Muscle Research and Cell Motility. 30: 303-6. PMID 20217194 DOI: 10.1007/S10974-010-9207-8  0.801
2009 Shaffer JF, Kensler RW, Harris SP. The myosin-binding protein C motif binds to F-actin in a phosphorylation-sensitive manner. The Journal of Biological Chemistry. 284: 12318-27. PMID 19269976 DOI: 10.1074/Jbc.M808850200  0.812
2009 Harris SP, Shaffer JF, Bezold KL, Kensler RW. Switching Gears with Myosin Binding Protein-C Biophysical Journal. 96: 4a. DOI: 10.1016/J.Bpj.2008.12.912  0.827
2009 Bezold KL, Shaffer JF, Harris SP. Functional Effects of cMyBP-C Phospho-Mimics in Permeabilized Trabeculae Biophysical Journal. 96: 500a. DOI: 10.1016/J.Bpj.2008.12.2581  0.764
2009 Shaffer JF, Jia W, Leary JA, Harris SP. PKA Phosphorylates Serine 307 of Murine Cardiac Myosin Binding Protein-C In Vitro Biophysical Journal. 96: 500a. DOI: 10.1016/J.Bpj.2008.12.2580  0.77
2009 Shaffer JF, Kensler RW, Harris SP. The N-terminus of Cardiac Myosin Binding Protein-C Contains Multiple Binding Sites for F-actin Biophysical Journal. 96: 371a. DOI: 10.1016/J.Bpj.2008.12.2000  0.818
2008 Whitten AE, Jeffries CM, Harris SP, Trewhella J. Cardiac myosin-binding protein C decorates F-actin: implications for cardiac function. Proceedings of the National Academy of Sciences of the United States of America. 105: 18360-5. PMID 19011110 DOI: 10.1073/Pnas.0808903105  0.691
2008 Razumova MV, Bezold KL, Tu AY, Regnier M, Harris SP. Contribution of the myosin binding protein C motif to functional effects in permeabilized rat trabeculae. The Journal of General Physiology. 132: 575-85. PMID 18955596 DOI: 10.1085/Jgp.200810013  0.655
2008 Luther PK, Bennett PM, Knupp C, Craig R, Padrón R, Harris SP, Patel J, Moss RL. Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle. Journal of Molecular Biology. 384: 60-72. PMID 18817784 DOI: 10.1016/J.Jmb.2008.09.013  0.439
2008 Jeffries CM, Whitten AE, Harris SP, Trewhella J. Small-angle X-ray scattering reveals the N-terminal domain organization of cardiac myosin binding protein C. Journal of Molecular Biology. 377: 1186-99. PMID 18313073 DOI: 10.1016/J.Jmb.2008.01.080  0.593
2008 Kensler RW, Harris SP. The structure of isolated cardiac Myosin thick filaments from cardiac Myosin binding protein-C knockout mice. Biophysical Journal. 94: 1707-18. PMID 17993479 DOI: 10.1529/biophysj.107.115899  0.557
2008 Jeffries C, Whitten A, Harris S, Trewhella J. Small-angle scattering: the regulatory domains of cardiac C-protein and their complex with F-actin Acta Crystallographica Section a Foundations of Crystallography. 64: C297-C297. DOI: 10.1107/S010876730809051X  0.433
2008 Whitten A, Jeffries C, Harris S, Trewhella J. A small-angle neutron contrast variation study of the complex of actin and myosin binding protein C Acta Crystallographica Section a Foundations of Crystallography. 64: C297-C297. DOI: 10.1107/S0108767308090508  0.522
2007 Shaffer JF, Razumova MV, Tu AY, Regnier M, Harris SP. Myosin S2 is not required for effects of myosin binding protein-C on motility. Febs Letters. 581: 1501-4. PMID 17376443 DOI: 10.1016/J.Febslet.2007.03.007  0.782
2006 Razumova MV, Shaffer JF, Tu AY, Flint GV, Regnier M, Harris SP. Effects of the N-terminal domains of myosin binding protein-C in an in vitro motility assay: Evidence for long-lived cross-bridges. The Journal of Biological Chemistry. 281: 35846-54. PMID 17012744 DOI: 10.1074/Jbc.M606949200  0.812
2004 Harris SP, Rostkova E, Gautel M, Moss RL. Binding of myosin binding protein-C to myosin subfragment S2 affects contractility independent of a tether mechanism. Circulation Research. 95: 930-6. PMID 15472117 DOI: 10.1161/01.RES.0000147312.02673.56  0.596
2004 Palmer BM, Georgakopoulos D, Janssen PM, Wang Y, Alpert NR, Belardi DF, Harris SP, Moss RL, Burgon PG, Seidman CE, Seidman JG, Maughan DW, Kass DA. Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening. Circulation Research. 94: 1249-55. PMID 15059932 DOI: 10.1161/01.Res.0000126898.95550.31  0.405
2003 Korte FS, McDonald KS, Harris SP, Moss RL. Loaded shortening, power output, and rate of force redevelopment are increased with knockout of cardiac myosin binding protein-C. Circulation Research. 93: 752-8. PMID 14500336 DOI: 10.1161/01.Res.0000096363.85588.9A  0.499
2002 Harris SP, Bartley CR, Hacker TA, McDonald KS, Douglas PS, Greaser ML, Powers PA, Moss RL. Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice. Circulation Research. 90: 594-601. PMID 11909824 DOI: 10.1161/01.Res.0000012222.70819.64  0.503
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