| Year |
Citation |
Score |
| 2023 |
Groelly FJ, Dagg RA, Mailler J, Halazonetis TD, Tarsounas M. High-resolution mapping of mitotic DNA synthesis under conditions of replication stress in cultured cells. Star Protocols. 4: 101970. PMID 36598851 DOI: 10.1016/j.xpro.2022.101970 |
0.372 |
|
| 2022 |
Petropoulos M, Champeris Tsaniras S, Nikou S, Maxouri S, Dionellis VS, Kalogeropoulou A, Karamichali A, Ioannidis K, Danalatos IR, Obst M, Naumann R, Delinasios GJ, Gorgoulis VG, Roukos V, Anastassiadis K, ... Halazonetis TD, et al. Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage. The Journal of Pathology. PMID 36210634 DOI: 10.1002/path.6017 |
0.409 |
|
| 2022 |
Groelly FJ, Dagg RA, Petropoulos M, Rossetti GG, Prasad B, Panagopoulos A, Paulsen T, Karamichali A, Jones SE, Ochs F, Dionellis VS, Puig Lombardi E, Miossec MJ, Lockstone H, Legube G, ... ... Halazonetis TD, et al. Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells. Molecular Cell. PMID 36002001 DOI: 10.1016/j.molcel.2022.07.011 |
0.408 |
|
| 2022 |
Bhowmick R, Lerdrup M, Gadi SA, Rossetti GG, Singh MI, Liu Y, Halazonetis TD, Hickson ID. RAD51 protects human cells from transcription-replication conflicts. Molecular Cell. PMID 36002000 DOI: 10.1016/j.molcel.2022.07.010 |
0.332 |
|
| 2021 |
Mailler J, Padayachy L, Halazonetis TD. A method to sequence genomic sites of mitotic DNA synthesis in mammalian cells. Methods in Enzymology. 661: 283-304. PMID 34776216 DOI: 10.1016/bs.mie.2021.08.013 |
0.332 |
|
| 2021 |
Petropoulos M, Halazonetis TD. Delayed DNA break repair for genome stability. Nature Cell Biology. 23: 1055-1057. PMID 34616021 DOI: 10.1038/s41556-021-00769-9 |
0.315 |
|
| 2021 |
Dagg RA, Zonderland G, Lombardi EP, Rossetti GG, Groelly FJ, Barroso S, Tacconi EMC, Wright B, Lockstone H, Aguilera A, Halazonetis TD, Tarsounas M. A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells. Nature Communications. 12: 4919. PMID 34389725 DOI: 10.1038/s41467-021-25215-0 |
0.315 |
|
| 2020 |
Rossetti GG, Sotiriou SK, Halazonetis TD. Draining the FEN1s for cancer therapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 32817488 DOI: 10.1073/Pnas.2014862117 |
0.51 |
|
| 2020 |
Macheret M, Bhowmick R, Sobkowiak K, Padayachy L, Mailler J, Hickson ID, Halazonetis TD. High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing. Cell Research. PMID 32561860 DOI: 10.1038/S41422-020-0358-X |
0.493 |
|
| 2019 |
Sotiriou SK, Halazonetis TD. Remodeling Collapsed DNA Replication Forks for Cancer Development. Cancer Research. 79: 1297-1298. PMID 30936075 DOI: 10.1158/0008-5472.Can-19-0216 |
0.531 |
|
| 2019 |
Macheret M, Halazonetis TD. Monitoring early S-phase origin firing and replication fork movement by sequencing nascent DNA from synchronized cells. Nature Protocols. 14: 51-67. PMID 30487655 DOI: 10.1038/S41596-018-0081-Y |
0.491 |
|
| 2019 |
Halazonetis T. Abstract PL03-02: Exploiting DNA replication stress for cancer therapies Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-Pl03-02 |
0.543 |
|
| 2018 |
Macheret M, Halazonetis TD. Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress. Nature. PMID 29466339 DOI: 10.1038/Nature25507 |
0.517 |
|
| 2017 |
Lugli N, Sotiriou SK, Halazonetis TD. The role of SMARCAL1 in replication fork stability and telomere maintenance. Dna Repair. PMID 28623093 DOI: 10.1016/J.Dnarep.2017.06.015 |
0.506 |
|
| 2017 |
Lugli N, Dionellis VS, Ordóñez-Morán P, Kamileri I, Sotiriou SK, Huelsken J, Halazonetis TD. Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue. Cell Reports. 19: 2185-2192. PMID 28614706 DOI: 10.1016/J.Celrep.2017.05.051 |
0.309 |
|
| 2017 |
Crefcoeur RP, Zgheib O, Halazonetis TD. A Model to Investigate Single-Strand DNA Responses in G1 Human Cells via a Telomere-Targeted, Nuclease-Deficient CRISPR-Cas9 System. Plos One. 12: e0169126. PMID 28046023 DOI: 10.1371/Journal.Pone.0169126 |
0.839 |
|
| 2016 |
Sotiriou SK, Kamileri I, Lugli N, Evangelou K, Da-Ré C, Huber F, Padayachy L, Tardy S, Nicati NL, Barriot S, Ochs F, Lukas C, Lukas J, Gorgoulis VG, Scapozza L, ... Halazonetis TD, et al. Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks. Molecular Cell. 64: 1127-1134. PMID 27984746 DOI: 10.1016/J.Molcel.2016.10.038 |
0.547 |
|
| 2016 |
Roumelioti FM, Sotiriou SK, Katsini V, Chiourea M, Halazonetis TD, Gagos S. Alternative lengthening of human telomeres is a conservative DNA replication process with features of break-induced replication. Embo Reports. PMID 27760777 DOI: 10.15252/Embr.201643169 |
0.542 |
|
| 2016 |
Murga M, Lecona E, Kamileri I, Díaz M, Lugli N, Sotiriou SK, Anton ME, Méndez J, Halazonetis TD, Fernandez-Capetillo O. POLD3 Is Haploinsufficient for DNA Replication in Mice. Molecular Cell. PMID 27524497 DOI: 10.1016/J.Molcel.2016.07.007 |
0.51 |
|
| 2015 |
Kocy?owski MK, Rey AJ, Stewart GS, Halazonetis TD. Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168. Cell Cycle (Georgetown, Tex.). 14: 1748-58. PMID 25695757 DOI: 10.1080/15384101.2015.1010918 |
0.544 |
|
| 2015 |
Macheret M, Halazonetis TD. DNA replication stress as a hallmark of cancer. Annual Review of Pathology. 10: 425-48. PMID 25621662 DOI: 10.1146/Annurev-Pathol-012414-040424 |
0.448 |
|
| 2015 |
Da-Rè C, Halazonetis TD. DNA replication stress as an Achilles' heel of cancer. Oncotarget. 6: 1-2. PMID 25595910 DOI: 10.18632/Oncotarget.3147 |
0.416 |
|
| 2015 |
Lugli N, Kamileri I, Halazonetis TD. PARP inhibitors and IR join forces to strike glioblastoma-initiating cells. Cell Death and Differentiation. 21: 192-3. PMID 24413198 DOI: 10.1038/Cdd.2013.172 |
0.397 |
|
| 2014 |
Halazonetis TD. Conservative DNA replication. Nature Reviews. Molecular Cell Biology. 15: 300. PMID 24667655 DOI: 10.1038/Nrm3784 |
0.469 |
|
| 2014 |
Emamzadah S, Tropia L, Vincenti I, Falquet B, Halazonetis TD. Reversal of the DNA-binding-induced loop L1 conformational switch in an engineered human p53 protein. Journal of Molecular Biology. 426: 936-44. PMID 24374182 DOI: 10.1016/J.Jmb.2013.12.020 |
0.521 |
|
| 2014 |
Costantino L, Sotiriou SK, Rantala JK, Magin S, Mladenov E, Helleday T, Haber JE, Iliakis G, Kallioniemi OP, Halazonetis TD. Break-induced replication repair of damaged forks induces genomic duplications in human cells Science. 343: 88-91. PMID 24310611 DOI: 10.1126/Science.1243211 |
0.528 |
|
| 2013 |
Velimezi G, Liontos M, Vougas K, Roumeliotis T, Bartkova J, Sideridou M, Dereli-Oz A, Kocylowski M, Pateras IS, Evangelou K, Kotsinas A, Orsolic I, Bursac S, Cokaric-Brdovcak M, Zoumpourlis V, ... ... Halazonetis TD, et al. Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nature Cell Biology. 15: 967-77. PMID 23851489 DOI: 10.1038/Ncb2795 |
0.494 |
|
| 2013 |
Crefcoeur RP, Yin R, Ulm R, Halazonetis TD. Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells. Nature Communications. 4: 1779. PMID 23653191 DOI: 10.1038/Ncomms2800 |
0.379 |
|
| 2013 |
Schepeler T, Lamy P, Hvidberg V, Laurberg JR, Fristrup N, Reinert T, Bartkova J, Tropia L, Bartek J, Halazonetis TD, Pan CC, Borre M, Dyrskjøt L, Orntoft TF. A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response. Oncogene. 32: 3577-86. PMID 22926521 DOI: 10.1038/Onc.2012.381 |
0.379 |
|
| 2012 |
Nikolaev SI, Sotiriou SK, Pateras IS, Santoni F, Sougioultzis S, Edgren H, Almusa H, Robyr D, Guipponi M, Saarela J, Gorgoulis VG, Antonarakis SE, Halazonetis TD. A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas. Cancer Research. 72: 6279-89. PMID 23204322 DOI: 10.1158/0008-5472.Can-12-3869 |
0.445 |
|
| 2012 |
Kohzaki M, Chiourea M, Versini G, Adachi N, Takeda S, Gagos S, Halazonetis TD. The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation. Carcinogenesis. 33: 1203-10. PMID 22508716 DOI: 10.1093/Carcin/Bgs149 |
0.526 |
|
| 2012 |
Nishimura T, Molinard G, Petty TJ, Broger L, Gabus C, Halazonetis TD, Thore S, Paszkowski J. Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1. Plos Genetics. 8: e1002484. PMID 22346760 DOI: 10.1371/Journal.Pgen.1002484 |
0.355 |
|
| 2012 |
Nikolaev SI, Rimoldi D, Iseli C, Valsesia A, Robyr D, Gehrig C, Harshman K, Guipponi M, Bukach O, Zoete V, Michielin O, Muehlethaler K, Speiser D, Beckmann JS, Xenarios I, ... Halazonetis TD, et al. Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. Nature Genetics. 44: 133-9. PMID 22197931 DOI: 10.1038/Ng.1026 |
0.346 |
|
| 2012 |
Zoumpourlis V, Zachos G, Halazonetis T, Ergazaki M, Spandidos D. Binding of wild-type and mutant forms of p53 protein from human tumors to a specific DNA-sequence of the first intron of the h-ras oncogene. International Journal of Oncology. 7: 1035-41. PMID 21552928 DOI: 10.3892/Ijo.7.5.1035 |
0.427 |
|
| 2012 |
Spandidos D, Zoumpourlis V, Zachos G, Toas S, Halazonetis T. Specific recognition of a transcriptional element within the human h-ras protooncogene by the p53 tumor-suppressor. International Journal of Oncology. 7: 1029-34. PMID 21552927 DOI: 10.3892/Ijo.7.5.1029 |
0.39 |
|
| 2012 |
Schepeler T, Lamy P, Laurberg J, Fristrup N, Bartkova J, Hvidbjerg V, Tropia L, Bartek J, Halazonetis TD, Reinert T, Borre M, Dyrskjøt L, Ørntoft TF. Abstract 3109: Correlation between genomic aberrations and the DNA damage response in bladder cancer Cancer Research. 72: 3109-3109. DOI: 10.1158/1538-7445.Am2012-3109 |
0.364 |
|
| 2011 |
Emamzadah S, Tropia L, Halazonetis TD. Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A (p21) p53-response element. Molecular Cancer Research : McR. 9: 1493-9. PMID 21933903 DOI: 10.1158/1541-7786.Mcr-11-0351 |
0.493 |
|
| 2011 |
Dereli-Öz A, Versini G, Halazonetis TD. Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress. Molecular Oncology. 5: 308-14. PMID 21641882 DOI: 10.1016/J.Molonc.2011.05.002 |
0.471 |
|
| 2011 |
Petty TJ, Emamzadah S, Costantino L, Petkova I, Stavridi ES, Saven JG, Vauthey E, Halazonetis TD. An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. The Embo Journal. 30: 2167-76. PMID 21522129 DOI: 10.1038/Emboj.2011.127 |
0.535 |
|
| 2011 |
Pasi CE, Dereli-Öz A, Negrini S, Friedli M, Fragola G, Lombardo A, Van Houwe G, Naldini L, Casola S, Testa G, Trono D, Pelicci PG, Halazonetis TD. Genomic instability in induced stem cells. Cell Death and Differentiation. 18: 745-53. PMID 21311564 DOI: 10.1038/Cdd.2011.9 |
0.341 |
|
| 2010 |
Cescutti R, Negrini S, Kohzaki M, Halazonetis TD. TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint. The Embo Journal. 29: 3723-32. PMID 20871591 DOI: 10.1038/Emboj.2010.238 |
0.537 |
|
| 2010 |
Gorgoulis VG, Halazonetis TD. Oncogene-induced senescence: the bright and dark side of the response. Current Opinion in Cell Biology. 22: 816-27. PMID 20807678 DOI: 10.1016/J.Ceb.2010.07.013 |
0.43 |
|
| 2010 |
Petty TJ, Nishimura T, Emamzadah S, Gabus C, Paszkowski J, Halazonetis TD, Thore S. Expression, crystallization and preliminary X-ray diffraction analysis of the CMM2 region of the Arabidopsis thaliana Morpheus' molecule 1 protein. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 916-8. PMID 20693667 DOI: 10.1107/S1744309110021068 |
0.354 |
|
| 2010 |
Kohzaki M, Nishihara K, Hirota K, Sonoda E, Yoshimura M, Ekino S, Butler JE, Watanabe M, Halazonetis TD, Takeda S. DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken. The Journal of Cell Biology. 189: 1117-27. PMID 20584917 DOI: 10.1083/Jcb.200912012 |
0.471 |
|
| 2010 |
Hou Z, Peng H, White DE, Wang P, Lieberman PM, Halazonetis T, Rauscher FJ. 14-3-3 Binding sites in the snail protein are essential for snail-mediated transcriptional repression and epithelial-mesenchymal differentiation Cancer Research. 70: 4385-4393. PMID 20501852 DOI: 10.1158/0008-5472.Can-10-0070 |
0.376 |
|
| 2010 |
Negrini S, Gorgoulis VG, Halazonetis TD. Genomic instability--an evolving hallmark of cancer. Nature Reviews. Molecular Cell Biology. 11: 220-8. PMID 20177397 DOI: 10.1038/Nrm2858 |
0.439 |
|
| 2009 |
Lempiäinen H, Halazonetis TD. Emerging common themes in regulation of PIKKs and PI3Ks. The Embo Journal. 28: 3067-73. PMID 19779456 DOI: 10.1038/Emboj.2009.281 |
0.444 |
|
| 2009 |
Pataky K, Villanueva G, Liani A, Zgheib O, Jenkins N, Halazonetis DJ, Halazonetis TD, Brugger J. Microcollimator for micrometer-wide stripe irradiation of cells using 20-30 keV X rays. Radiation Research. 172: 252-9. PMID 19630530 DOI: 10.1667/Rr1483.1 |
0.772 |
|
| 2009 |
Liontos M, Niforou K, Velimezi G, Vougas K, Evangelou K, Apostolopoulou K, Vrtel R, Damalas A, Kontovazenitis P, Kotsinas A, Zoumpourlis V, Tsangaris GT, Kittas C, Ginsberg D, Halazonetis TD, et al. Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. The American Journal of Pathology. 175: 376-91. PMID 19541929 DOI: 10.2353/Ajpath.2009.081160 |
0.507 |
|
| 2009 |
Zgheib O, Pataky K, Brugger J, Halazonetis TD. An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks. Molecular and Cellular Biology. 29: 1050-8. PMID 19064641 DOI: 10.1128/Mcb.01011-08 |
0.836 |
|
| 2008 |
Halazonetis TD, Gorgoulis VG, Bartek J. An oncogene-induced DNA damage model for cancer development. Science (New York, N.Y.). 319: 1352-5. PMID 18323444 DOI: 10.1126/Science.1140735 |
0.554 |
|
| 2008 |
Halazonetis T, Zgheib O, Gorgoulis V, Bartek J. An oncogene-induced DNA replication stress model for human cancer development European Journal of Cancer Supplements. 6: 63-64. DOI: 10.1016/S1359-6349(08)71417-4 |
0.544 |
|
| 2007 |
Tuttle RL, Bothos J, Summers MK, Luca FC, Halazonetis TD. Defective in mitotic arrest 1/ring finger 8 is a checkpoint protein that antagonizes the human mitotic exit network. Molecular Cancer Research : McR. 5: 1304-11. PMID 18171988 DOI: 10.1158/1541-7786.Mcr-07-0388 |
0.803 |
|
| 2007 |
Liontos M, Koutsami M, Sideridou M, Evangelou K, Kletsas D, Levy B, Kotsinas A, Nahum O, Zoumpourlis V, Kouloukoussa M, Lygerou Z, Taraviras S, Kittas C, Bartkova J, Papavassiliou AG, ... ... Halazonetis TD, et al. Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Research. 67: 10899-909. PMID 18006835 DOI: 10.1158/0008-5472.Can-07-2837 |
0.454 |
|
| 2007 |
Venere M, Snyder A, Zgheib O, Halazonetis TD. Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function. Cancer Research. 67: 6100-5. PMID 17616665 DOI: 10.1158/0008-5472.Can-07-0369 |
0.813 |
|
| 2007 |
Tsimaratou K, Kletsas D, Kastrinakis NG, Tsantoulis PK, Evangelou K, Sideridou M, Liontos M, Poulias I, Venere M, Salmas M, Kittas C, Halazonetis TD, Gorgoulis VG. Evaluation of claspin as a proliferation marker in human cancer and normal tissues. The Journal of Pathology. 211: 331-9. PMID 17152083 DOI: 10.1002/Path.2095 |
0.672 |
|
| 2006 |
Halazonetis TD, Bartek J. DNA damage signaling recruits the RNA polymerase II binding protein Che-1 to the p53 promoter. Molecular Cell. 24: 809-10. PMID 17189183 DOI: 10.1016/J.Molcel.2006.12.004 |
0.5 |
|
| 2006 |
Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, ... ... Halazonetis TD, et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature. 444: 633-7. PMID 17136093 DOI: 10.1038/Nature05268 |
0.537 |
|
| 2006 |
Peschiaroli A, Dorrello NV, Guardavaccaro D, Venere M, Halazonetis T, Sherman NE, Pagano M. SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Molecular Cell. 23: 319-29. PMID 16885022 DOI: 10.1016/J.Molcel.2006.06.013 |
0.761 |
|
| 2006 |
Lukas J, Bohr VA, Halazonetis TD. Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium. Dna Repair. 5: 591-601. PMID 16504601 DOI: 10.1016/J.Dnarep.2006.01.006 |
0.479 |
|
| 2005 |
Livingstone M, Ruan H, Weiner J, Clauser KR, Strack P, Jin S, Williams A, Greulich H, Gardner J, Venere M, Mochan TA, DiTullio RA, Moravcevic K, Gorgoulis VG, Burkhardt A, ... Halazonetis TD, et al. Valosin-containing protein phosphorylation at Ser784 in response to DNA damage. Cancer Research. 65: 7533-40. PMID 16140914 DOI: 10.1158/0008-5472.Can-04-3729 |
0.817 |
|
| 2005 |
Bothos J, Tuttle RL, Ottey M, Luca FC, Halazonetis TD. Human LATS1 is a mitotic exit network kinase. Cancer Research. 65: 6568-75. PMID 16061636 DOI: 10.1158/0008-5472.Can-05-0862 |
0.803 |
|
| 2005 |
Zgheib O, Huyen Y, DiTullio RA, Snyder A, Venere M, Stavridi ES, Halazonetis TD. ATM signaling and 53BP1. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 76: 119-22. PMID 16024119 DOI: 10.1016/J.Radonc.2005.06.026 |
0.812 |
|
| 2005 |
Stavridi ES, Halazonetis TD. Nbs1 moving up in the world. Nature Cell Biology. 7: 648-50. PMID 15990895 DOI: 10.1038/Ncb0705-648 |
0.549 |
|
| 2005 |
Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio RA, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature. 434: 907-13. PMID 15829965 DOI: 10.1038/Nature03485 |
0.842 |
|
| 2005 |
Summers MK, Bothos J, Halazonetis TD. The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleus. Oncogene. 24: 2589-98. PMID 15674323 DOI: 10.1038/Sj.Onc.1208428 |
0.786 |
|
| 2004 |
Huyen Y, Zgheib O, Ditullio RA, Gorgoulis VG, Zacharatos P, Petty TJ, Sheston EA, Mellert HS, Stavridi ES, Halazonetis TD. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature. 432: 406-11. PMID 15525939 DOI: 10.1038/Nature03114 |
0.792 |
|
| 2004 |
Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC. Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. The Journal of Cell Biology. 166: 801-13. PMID 15364958 DOI: 10.1083/Jcb.200405128 |
0.529 |
|
| 2004 |
MacPherson D, Kim J, Kim T, Rhee BK, Van Oostrom CT, DiTullio RA, Venere M, Halazonetis TD, Bronson R, De Vries A, Fleming M, Jacks T. Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. The Embo Journal. 23: 3689-99. PMID 15343266 DOI: 10.1038/Sj.Emboj.7600363 |
0.785 |
|
| 2004 |
Halazonetis TD. Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer. Dna Repair. 3: 1057-62. PMID 15279793 DOI: 10.1016/J.Dnarep.2004.03.036 |
0.572 |
|
| 2004 |
Mochan TA, Venere M, DiTullio RA, Halazonetis TD. 53BP1, an activator of ATM in response to DNA damage. Dna Repair. 3: 945-52. PMID 15279780 DOI: 10.1016/J.Dnarep.2004.03.017 |
0.825 |
|
| 2004 |
Huyen Y, Jeffrey PD, Derry WB, Rothman JH, Pavletich NP, Stavridi ES, Halazonetis TD. Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1. Structure (London, England : 1993). 12: 1237-43. PMID 15242600 DOI: 10.1016/J.Str.2004.05.007 |
0.816 |
|
| 2004 |
Stavridi ES, Halazonetis TD. p53 and stress in the ER. Genes & Development. 18: 241-4. PMID 14871924 DOI: 10.1101/Gad.1181704 |
0.443 |
|
| 2003 |
Mochan TA, Venere M, DiTullio RA, Halazonetis TD. 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Research. 63: 8586-91. PMID 14695167 |
0.814 |
|
| 2003 |
Mariatos G, Bothos J, Zacharatos P, Summers MK, Scolnick DM, Kittas C, Halazonetis TD, Gorgoulis VG. Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer. Cancer Research. 63: 7185-9. PMID 14612512 |
0.773 |
|
| 2003 |
Bothos J, Summers MK, Venere M, Scolnick DM, Halazonetis TD. The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. Oncogene. 22: 7101-7. PMID 14562038 DOI: 10.1038/Sj.Onc.1206831 |
0.782 |
|
| 2003 |
Corn PG, Summers MK, Fogt F, Virmani AK, Gazdar AF, Halazonetis TD, El-Deiry WS. Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer. Carcinogenesis. 24: 47-51. PMID 12538348 DOI: 10.1093/Carcin/24.1.47 |
0.341 |
|
| 2002 |
DiTullio RA, Mochan TA, Venere M, Bartkova J, Sehested M, Bartek J, Halazonetis TD. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nature Cell Biology. 4: 998-1002. PMID 12447382 DOI: 10.1038/Ncb892 |
0.823 |
|
| 2002 |
Venere M, Mochan TA, Halazonetis TD. Chk2 leaves the PML depot. Nature Cell Biology. 4: E255-6. PMID 12415282 DOI: 10.1038/Ncb1102-E255 |
0.778 |
|
| 2002 |
Stavridi ES, Huyen Y, Loreto IR, Scolnick DM, Halazonetis TD, Pavletich NP, Jeffrey PD. Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate Structure. 10: 891-899. PMID 12121644 DOI: 10.1016/S0969-2126(02)00776-1 |
0.766 |
|
| 2001 |
Barlev NA, Liu L, Chehab NH, Mansfield K, Harris KG, Halazonetis TD, Berger SL. Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases Molecular Cell. 8: 1243-1254. PMID 11779500 DOI: 10.1016/S1097-2765(01)00414-2 |
0.419 |
|
| 2001 |
Schultz LB, Chehab NH, Malikzay A, Halazonetis TD. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. The Journal of Cell Biology. 151: 1381-90. PMID 11134068 DOI: 10.1083/Jcb.151.7.1381 |
0.588 |
|
| 2000 |
Schultz LB, Chehab NH, Malikzay A, DiTullio RA, Stavridi ES, Halazonetis TD. The DNA damage checkpoint and human cancer. Cold Spring Harbor Symposia On Quantitative Biology. 65: 489-98. PMID 12760066 DOI: 10.1101/Sqb.2000.65.489 |
0.823 |
|
| 2000 |
Cinti C, Claudio PP, Luca AD, Cuccurese M, Howard CM, D'Esposito M, Paggi MG, Sala DL, Azzoni L, Halazonetis TD, Giordano A, Maraldi NM. A serine 37 mutation associated with two missense mutations at highly conserved regions of p53 affect pro-apoptotic genes expression in a T-lymphoblastoid drug resistant cell line. Oncogene. 19: 5098-105. PMID 11042698 DOI: 10.1038/Sj.Onc.1203848 |
0.506 |
|
| 2000 |
Scolnick DM, Halazonetis TD. Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature. 406: 430-5. PMID 10935642 DOI: 10.1038/35019108 |
0.787 |
|
| 2000 |
Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proceedings of the National Academy of Sciences of the United States of America. 96: 13777-82. PMID 10570149 DOI: 10.1073/Pnas.96.24.13777 |
0.473 |
|
| 2000 |
Stavridi ES, Chehab NH, Caruso LC, Halazonetis TD. Change in oligomerization specificity of the p53 tetramerization domain by hydrophobic amino acid substitutions. Protein Science : a Publication of the Protein Society. 8: 1773-9. PMID 10493578 DOI: 10.1110/Ps.8.9.1773 |
0.38 |
|
| 2000 |
Chehab NH, Malikzay A, Appel M, Halazonetis TD. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes & Development. 14: 278-288. DOI: 10.1101/Gad.14.3.278 |
0.569 |
|
| 1999 |
Megyeri K, Berencsi K, Halazonetis TD, Prendergast GC, Gri G, Plotkin SA, Rovera G, Gönczöl E. Involvement of a p53-dependent pathway in rubella virus-induced apoptosis. Virology. 259: 74-84. PMID 10364491 DOI: 10.1006/Viro.1999.9757 |
0.329 |
|
| 1999 |
Liu L, Scolnick DM, Trievel RC, Zhang HB, Marmorstein R, Halazonetis TD, Berger SL. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Molecular and Cellular Biology. 19: 1202-9. PMID 9891054 DOI: 10.1128/Mcb.19.2.1202 |
0.818 |
|
| 1998 |
Gorgoulis VG, Zacharatos P, Kotsinas A, Liloglou T, Kyroudi A, Veslemes M, Rassidakis A, Halazonetis TD, Field JK, Kittas C. Alterations of the p16-pRb pathway and the chromosome locus 9p21-22 in non-small-cell lung carcinomas: relationship with p53 and MDM2 protein expression. The American Journal of Pathology. 153: 1749-65. PMID 9846966 DOI: 10.1016/S0002-9440(10)65690-8 |
0.343 |
|
| 1998 |
Waterman MJ, Stavridi ES, Waterman JL, Halazonetis TD. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nature Genetics. 19: 175-8. PMID 9620776 DOI: 10.1038/542 |
0.569 |
|
| 1998 |
Müller-Tiemann BF, Halazonetis TD, Elting JJ. Identification of an additional negative regulatory region for p53 sequence-specific DNA binding. Proceedings of the National Academy of Sciences of the United States of America. 95: 6079-84. PMID 9600920 DOI: 10.1073/Pnas.95.11.6079 |
0.451 |
|
| 1998 |
Gorgoulis VG, Zacharatos PV, Manolis E, Ikonomopoulos JA, Damalas A, Lamprinopoulos C, Rassidakis GZ, Zoumpourlis V, Kotsinas A, Rassidakis AN, Halazonetis TD, Kittas C. Effects of p53 mutants derived from lung carcinomas on the p53-responsive element (p53RE) of the MDM2 gene. British Journal of Cancer. 77: 374-84. PMID 9472631 DOI: 10.1038/Bjc.1998.60 |
0.408 |
|
| 1997 |
Scolnick DM, Chehab NH, Stavridi ES, Lien MC, Caruso L, Moran E, Berger SL, Halazonetis TD. CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein. Cancer Research. 57: 3693-6. PMID 9288775 |
0.792 |
|
| 1997 |
Candau R, Scolnick DM, Darpino P, Ying CY, Halazonetis TD, Berger SL. Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity. Oncogene. 15: 807-16. PMID 9266967 DOI: 10.1038/Sj.Onc.1201244 |
0.799 |
|
| 1996 |
Wieczorek AM, Waterman JL, Waterman MJ, Halazonetis TD. Structure-based rescue of common tumor-derived p53 mutants. Nature Medicine. 2: 1143-6. PMID 8837616 DOI: 10.1038/Nm1096-1143 |
0.538 |
|
| 1995 |
Waterman J, Shenk J, Halazonetis T. The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding. The Embo Journal. 14: 512-519. DOI: 10.1002/J.1460-2075.1995.Tb07027.X |
0.515 |
|
| 1993 |
Halazonetis T, Kandil A. Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants. The Embo Journal. 12: 5057-5064. DOI: 10.1002/J.1460-2075.1993.Tb06199.X |
0.542 |
|
| 1993 |
Halazonetis T, Davis L, Kandil A. Wild-type p53 adopts a ‘mutant’-like conformation when bound to DNA. The Embo Journal. 12: 1021-1028. DOI: 10.1002/J.1460-2075.1993.Tb05743.X |
0.51 |
|
| 1992 |
Halazonetis TD, Kandil AN. Predicted structural similarities of the DNA binding domains of c-Myc and endonuclease Eco RI Science. 255: 464-466. PMID 1734524 DOI: 10.1126/Science.1734524 |
0.462 |
|
| 1992 |
Halazonetis T. DNA-binding domains of c-Myc Biomedicine & Pharmacotherapy. 46: 425. DOI: 10.1016/0753-3322(92)90049-D |
0.429 |
|
| 1991 |
Halazonetis TD, Kandil AN. Determination of the c-MYC DNA-binding site Proceedings of the National Academy of Sciences of the United States of America. 88: 6162-6166. PMID 2068097 DOI: 10.1073/Pnas.88.14.6162 |
0.475 |
|
| 1990 |
Zhang K, Chaillet JR, Perkins LA, Halazonetis TD, Perrimon N. Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 87: 6281-5. PMID 1696724 DOI: 10.1073/Pnas.87.16.6281 |
0.476 |
|
| 1988 |
Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P. c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell. 55: 917-24. PMID 3142692 DOI: 10.1016/0092-8674(88)90147-X |
0.387 |
|
| 1987 |
Sarid J, Halazonetis TD, Murphy W, Leder P. Evolutionarily conserved regions of the human c-myc protein can be uncoupled from transforming activity. Proceedings of the National Academy of Sciences of the United States of America. 84: 170-3. PMID 3467348 DOI: 10.1073/Pnas.84.1.170 |
0.302 |
|
| Show low-probability matches. |