| Year |
Citation |
Score |
| 2024 |
Yu X, Zhang Y, Cogliati B, Klaassen CD, Kumar S, Cheng X, Bu P. Distinct bile acid alterations in response to a single administration of PFOA and PFDA in mice. Toxicology. 153719. PMID 38181850 DOI: 10.1016/j.tox.2023.153719 |
0.738 |
|
| 2021 |
Xiong H, Zhang C, Han L, Xu T, Saeed K, Han J, Liu J, Klaassen CD, Gonzalez FJ, Lu Y, Zhang Y. Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity. Hepatology (Baltimore, Md.). PMID 34870866 DOI: 10.1002/hep.32270 |
0.602 |
|
| 2021 |
Fu ZD, Selwyn FP, Cui JY, Klaassen CD. RNA-Seq unveiled section-specific host response to lack of gut microbiota in mouse intestine. Toxicology and Applied Pharmacology. 115775. PMID 34715074 DOI: 10.1016/j.taap.2021.115775 |
0.621 |
|
| 2021 |
Liu J, Lickteig AJ, Zhang Y, Csanaky IL, Klaassen CD. Activation of Nrf2 decreases bile acid concentrations in livers of female mice. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-11. PMID 33522359 DOI: 10.1080/00498254.2021.1880033 |
0.728 |
|
| 2020 |
Liu J, Lu YF, Corton JC, Klaassen CD. Expression of cytochrome P450 isozyme transcripts and activities in human livers. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-24. PMID 33350342 DOI: 10.1080/00498254.2020.1867929 |
0.357 |
|
| 2020 |
Liu J, Cui JY, Lu YF, Corton JC, Klaassen CD. Sex-, age-, and race/ethnicity-dependent variations in drug-processing and NRF2-regulated genes in human livers. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 33162398 DOI: 10.1124/dmd.120.000181 |
0.644 |
|
| 2020 |
Wu KC, Reisman SA, Klaassen CD. Tissue distribution, hormonal regulation, ontogeny, diurnal expression, and induction of mouse cystine transporters Slc3a1 and Slc7a9. Free Radical Research. 1-10. PMID 32873097 DOI: 10.1080/10715762.2020.1812597 |
0.82 |
|
| 2020 |
Zhang Y, Lickteig AJ, Liu J, Csanaky IL, Klaassen CD. Effects of ablation and activation of Nrf2 on bile acid homeostasis in mice. Toxicology and Applied Pharmacology. 115170. PMID 32738332 DOI: 10.1016/J.Taap.2020.115170 |
0.74 |
|
| 2020 |
Csanaky IL, Lickteig AJ, Zhang Y, Klaassen CD. Effects of the patent ductus venosus on bile acid homeostasis in aryl hydrocarbon receptor (AhR)-null mice. Toxicology and Applied Pharmacology. 115136. PMID 32679164 DOI: 10.1016/J.Taap.2020.115136 |
0.742 |
|
| 2020 |
Choudhuri S, Klaassen CD. Elucidation of OATP1B1 and 1B3 transporter function using transgenic rodent models and commonly known single nucleotide polymorphisms. Toxicology and Applied Pharmacology. 399: 115039. PMID 32407928 DOI: 10.1016/J.Taap.2020.115039 |
0.414 |
|
| 2020 |
Liu J, Gunewardena S, Yue Cui J, Klaassen CD, Chorley BN, Corton JC. Transplacental arsenic exposure produced 5-methylcytosine methylation changes and aberrant microRNA expressions in livers of male fetal mice. Toxicology. 152409. PMID 32068019 DOI: 10.1016/J.Tox.2020.152409 |
0.351 |
|
| 2019 |
Wang P, Sachar M, Lu J, Shehu AI, Zhu J, Chen J, Liu K, Anderson KE, Xie W, Gonzalez FJ, Klaassen CD, Ma X. The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria. Science Advances. 5: eaaw6127. PMID 31555729 DOI: 10.1126/Sciadv.Aaw6127 |
0.314 |
|
| 2019 |
Li G, Han L, Ma R, Saeed K, Xiong H, Klaassen C, Lu Y, Zhang Y. Glucocorticoids increase renal excretion of urate in mice by down-regulating urate transporter 1. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31519697 DOI: 10.1124/dmd.119.087700 |
0.701 |
|
| 2019 |
Scialis RJ, Aleksunes LM, Csanaky IL, Klaassen CD, Manautou JE. Identification and Characterization of Efflux Transporters that Modulate the Subtoxic Disposition of Diclofenac and its Metabolites. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31399506 DOI: 10.1124/dmd.119.086603 |
0.304 |
|
| 2019 |
Lickteig AJ, Zhang Y, Klaassen CD, Csanaky IL. Effects of Absence of Constitutive Androstane Receptor (CAR) on Bile Acid Homeostasis in Male and Female Mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31225615 DOI: 10.1093/Toxsci/Kfz143 |
0.751 |
|
| 2019 |
Wen X, Baker AA, Klaassen CD, Corton JC, Richardson JR, Aleksunes LM. Hepatic Carboxylesterases are Differentially Regulated in PPARα-Null Mice Treated with Perfluorooctanoic Acid. Toxicology. PMID 30685356 DOI: 10.1016/J.Tox.2019.01.014 |
0.518 |
|
| 2019 |
Wu KC, Cui JY, Liu J, Lu H, Zhong XB, Klaassen CD. RNA-Seq provides new insights on the relative mRNA abundance of antioxidant components during mouse liver development. Free Radical Biology & Medicine. PMID 30659941 DOI: 10.1016/J.Freeradbiomed.2019.01.017 |
0.675 |
|
| 2018 |
Rooney J, Oshida K, Vasani N, Vallanat B, Ryan N, Chorley BN, Wang X, Bell DA, Wu KC, Aleksunes LM, Klaassen CD, Kensler TW, Corton JC. Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor. Plos One. 13: e0200004. PMID 30114225 DOI: 10.1371/Journal.Pone.0200004 |
0.47 |
|
| 2018 |
Liu J, Lu YF, Wu Q, Xu SF, Shi FG, Klaassen CD. Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses. Liver International : Official Journal of the International Association For the Study of the Liver. PMID 30079536 DOI: 10.1111/Liv.13940 |
0.382 |
|
| 2018 |
Csanaky IL, Lickteig AJ, Klaassen CD. Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in wild-type and AhR-null mice. Toxicology and Applied Pharmacology. PMID 29452137 DOI: 10.1016/J.Taap.2018.02.005 |
0.538 |
|
| 2018 |
Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD. Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion. Toxicology and Applied Pharmacology. 338: 112-123. PMID 29175453 DOI: 10.1016/J.Taap.2017.11.014 |
0.737 |
|
| 2017 |
Zhang Y, Zhang Y, Klaassen CD, Cheng X. Alteration of bile acid and cholesterol biosynthesis and transport by perfluorononanoic acid (PFNA) in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29112762 DOI: 10.1093/Toxsci/Kfx237 |
0.846 |
|
| 2017 |
Wang X, Han L, Li G, Peng W, Gao X, Klaassen CD, Fan G, Zhang Y. Identification of natural products as inhibitors of human organic anion transporters (OAT1 and OAT3) and their protective effect on mercury-induced toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29045746 DOI: 10.1093/Toxsci/Kfx216 |
0.632 |
|
| 2017 |
Choudhuri S, Patton GW, Chanderbhan RF, Mattia A, Klaassen CD. From Classical Toxicology To TOX21 Some Critical Conceptual and Technological Advances in the Molecular Understanding of the Toxic Response Beginning from the Last Quarter of the 20Th Century. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28973688 DOI: 10.1093/Toxsci/Kfx186 |
0.313 |
|
| 2017 |
Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD. Clofibrate decreases bile acids in livers of male mice by increasing biliary bile acid excretion in a PPARα-dependent manner. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28973556 DOI: 10.1093/Toxsci/Kfx191 |
0.752 |
|
| 2017 |
Fu ZD, Selwyn FP, Cui JY, Klaassen CD. RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 28939687 DOI: 10.1124/Dmd.117.077313 |
0.694 |
|
| 2016 |
Rockwell CE, Turley AE, Cheng X, Fields PE, Klaassen CD. Persistent alterations in immune cell populations and function from a single dose of perfluorononanoic acid (PFNA) in C57Bl/6 mice. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 27939831 DOI: 10.1016/J.Fct.2016.12.004 |
0.646 |
|
| 2016 |
Guo Y, Zhang Y, Huang W, Selwyn FP, Klaassen CD. Dose-response effect of berberine on bile acid profile and gut microbiota in mice. Bmc Complementary and Alternative Medicine. 16: 394. PMID 27756364 DOI: 10.1186/S12906-016-1367-7 |
0.648 |
|
| 2016 |
Guo Y, Cui JY, Lu H, Klaassen CD. Effect of nine diets on mRNAs of phase-II conjugation enzymes in livers of mice. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-10. PMID 27686132 DOI: 10.1080/00498254.2016.1213926 |
0.643 |
|
| 2016 |
Cui JY, Klaassen CD. RNA-Seq Reveals Common and Unique PXR- and CAR-target Gene Signatures in the Mouse Liver Transcriptome. Biochimica Et Biophysica Acta. PMID 27113289 DOI: 10.1016/J.Bbagrm.2016.04.010 |
0.683 |
|
| 2016 |
Fu ZD, Selwyn FP, Cui JY, Klaassen CD. RNA-Seq Quantification of Xenobiotic Processing Genes in Various Sections of the Intestine in Comparison to the Liver of Male Mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27048750 DOI: 10.1124/Dmd.115.068270 |
0.709 |
|
| 2016 |
Lickteig AJ, Csanaky IL, Pratt-Hyatt M, Klaassen CD. Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. 151: 403-18. PMID 26984780 DOI: 10.1093/Toxsci/Kfw054 |
0.831 |
|
| 2016 |
Renaud HJ, Klaassen CD, Csanaky IL. Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 44: 366-9. PMID 26744253 DOI: 10.1124/Dmd.115.064766 |
0.436 |
|
| 2015 |
Selwyn FP, Cheng SL, Klaassen CD, Cui JY. Regulation of Hepatic Drug-metabolizing Enzymes in Germ-free mice by Conventionalization and Probiotics. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26586378 DOI: 10.1124/Dmd.115.067504 |
0.704 |
|
| 2015 |
Li CY, Renaud HJ, Klaassen CD, Cui JY. Age-specific Regulation of Drug-processing Genes in Mouse Liver by Ligands of Xenobiotic-sensing Transcription Factors. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26577535 DOI: 10.1124/Dmd.115.066639 |
0.674 |
|
| 2015 |
Gunewardena SS, Yoo B, Peng L, Lu H, Zhong X, Klaassen CD, Cui JY. Deciphering the Developmental Dynamics of the Mouse Liver Transcriptome. Plos One. 10: e0141220. PMID 26496202 DOI: 10.1371/Journal.Pone.0141220 |
0.669 |
|
| 2015 |
Fu ZD, Cui JY, Klaassen CD. The Role of Sirt1 in Bile Acid Regulation during Calorie Restriction in Mice. Plos One. 10: e0138307. PMID 26372644 DOI: 10.1371/Journal.Pone.0138307 |
0.684 |
|
| 2015 |
Klaassen CD, Cui JY. Review: Mechanisms of How the Intestinal Microbiota Alters the Effects of Drugs and Bile Acids. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26261286 DOI: 10.1124/Dmd.115.065698 |
0.62 |
|
| 2015 |
Oshida K, Vasani N, Thomas RS, Applegate D, Gonzalez FJ, Aleksunes LM, Klaassen CD, Corton JC. Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR). Toxicology. 336: 99-112. PMID 26215100 DOI: 10.1016/J.Tox.2015.07.005 |
0.441 |
|
| 2015 |
Selwyn FP, Csanaky IL, Zhang Y, Klaassen CD. Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 1544-56. PMID 26199423 DOI: 10.1124/Dmd.115.065276 |
0.733 |
|
| 2015 |
Selwyn FP, Cheng SL, Bammler TK, Prasad B, Vrana M, Klaassen C, Cui JY. Developmental Regulation of Drug-processing Genes in Livers of Germ-free Mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26032512 DOI: 10.1093/Toxsci/Kfv110 |
0.729 |
|
| 2015 |
Selwyn FP, Cui JY, Klaassen CD. RNA-Seq Quantification of Hepatic Drug Processing Genes in Germ-Free mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 25956306 DOI: 10.1124/Dmd.115.063545 |
0.722 |
|
| 2015 |
Oshida K, Vasani N, Jones C, Moore T, Hester S, Nesnow S, Auerbach S, Geter DR, Aleksunes LM, Thomas RS, Applegate D, Klaassen CD, Corton JC. Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium. Nuclear Receptor Signaling. 13: e002. PMID 25949234 DOI: 10.1621/Nrs.13002 |
0.451 |
|
| 2015 |
Guo Y, Cui JY, Lu H, Klaassen CD. Effect of various diets on the expression of phase-I drug-metabolizing enzymes in livers of mice. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 45: 586-97. PMID 25733028 DOI: 10.3109/00498254.2015.1006300 |
0.646 |
|
| 2015 |
Oshida K, Vasani N, Thomas RS, Applegate D, Rosen M, Abbott B, Lau C, Guo G, Aleksunes LM, Klaassen C, Corton JC. Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium. Plos One. 10: e0112655. PMID 25689681 DOI: 10.1371/Journal.Pone.0112655 |
0.424 |
|
| 2015 |
Song P, Rockwell CE, Cui JY, Klaassen CD. Individual bile acids have differential effects on bile acid signaling in mice. Toxicology and Applied Pharmacology. 283: 57-64. PMID 25582706 DOI: 10.1016/J.Taap.2014.12.005 |
0.83 |
|
| 2015 |
Guo Y, Cui JY, Lu H, Klaassen CD. Effect of nine diets on xenobiotic transporters in livers of mice. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 45: 634-41. PMID 25566878 DOI: 10.3109/00498254.2014.1001009 |
0.654 |
|
| 2015 |
Lu YF, Liu J, Wu KC, Klaassen CD. Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2. Toxicology Letters. 232: 326-32. PMID 25280775 DOI: 10.1016/J.Toxlet.2014.09.027 |
0.503 |
|
| 2015 |
Oshida K, Vasani N, Thomas RS, Applegate D, Rosen M, Abbott B, Lau C, Guo G, Aleksunes LM, Klaassen C, Corton JC. Expression of Cyp4a10 and Pdk4 genes in the livers of mice exposed to reference compound activators of CAR, FXR, Nrf2, PPARα, and PXR. Plos One. DOI: 10.1371/Journal.Pone.0112655.G004 |
0.496 |
|
| 2014 |
Fu ZD, Cui JY, Klaassen CD. Atorvastatin induces bile acid-synthetic enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine in mice. Journal of Lipid Research. 55: 2576-86. PMID 25278499 DOI: 10.1194/Jlr.M053124 |
0.731 |
|
| 2014 |
Cheng X, Gu J, Klaassen CD. Adaptive hepatic and intestinal alterations in mice after deletion of NADPH-cytochrome P450 Oxidoreductase (Cpr) in hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1826-33. PMID 25147274 DOI: 10.1124/Dmd.114.060053 |
0.767 |
|
| 2014 |
Renaud HJ, Cui YJ, Lu H, Zhong XB, Klaassen CD. Ontogeny of hepatic energy metabolism genes in mice as revealed by RNA-sequencing. Plos One. 9: e104560. PMID 25102070 DOI: 10.1371/Journal.Pone.0104560 |
0.414 |
|
| 2014 |
Liu J, Lu H, Lu YF, Lei X, Cui JY, Ellis E, Strom SC, Klaassen CD. Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicological Sciences : An Official Journal of the Society of Toxicology. 141: 538-46. PMID 25055961 DOI: 10.1093/Toxsci/Kfu151 |
0.662 |
|
| 2014 |
Cheng X, Zhang Y, Klaassen CD. Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum. The Journal of Pharmacology and Experimental Therapeutics. 351: 105-13. PMID 25034404 DOI: 10.1124/Jpet.114.216796 |
0.83 |
|
| 2014 |
Raveendran VV, Kassel KM, Smith DD, Luyendyk JP, Williams KJ, Cherian R, Reed GA, Flynn CA, Csanaky IL, Lickteig AL, Pratt-Hyatt MJ, Klaassen CD, Dileepan KN. H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 307: G219-28. PMID 24852568 DOI: 10.1152/Ajpgi.00027.2014 |
0.839 |
|
| 2014 |
Qu Q, Liu J, Zhou HH, Klaassen CD. Nrf2 protects against furosemide-induced hepatotoxicity. Toxicology. 324: 35-42. PMID 24813929 DOI: 10.1016/J.Tox.2014.02.008 |
0.492 |
|
| 2014 |
Cheng X, Vispute SG, Liu J, Cheng C, Kharitonenkov A, Klaassen CD. Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR). Toxicology and Applied Pharmacology. 278: 65-71. PMID 24769090 DOI: 10.1016/J.Taap.2014.04.013 |
0.768 |
|
| 2014 |
Lu YF, Liu J, Wu KC, Qu Q, Fan F, Klaassen CD. Overexpression of Nrf2 protects against microcystin-induced hepatotoxicity in mice. Plos One. 9: e93013. PMID 24667526 DOI: 10.1371/Journal.Pone.0093013 |
0.52 |
|
| 2014 |
Zhang Y, Limaye PB, Renaud HJ, Klaassen CD. Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice. Toxicology and Applied Pharmacology. 277: 138-45. PMID 24657338 DOI: 10.1016/J.Taap.2014.03.009 |
0.668 |
|
| 2014 |
Clarke JD, Hardwick RN, Lake AD, Lickteig AJ, Goedken MJ, Klaassen CD, Cherrington NJ. Synergistic interaction between genetics and disease on pravastatin disposition. Journal of Hepatology. 61: 139-47. PMID 24613363 DOI: 10.1016/J.Jhep.2014.02.021 |
0.333 |
|
| 2014 |
Renaud HJ, Cui JY, Lu H, Klaassen CD. Effect of diet on expression of genes involved in lipid metabolism, oxidative stress, and inflammation in mouse liver-insights into mechanisms of hepatic steatosis. Plos One. 9: e88584. PMID 24551121 DOI: 10.1371/Journal.Pone.0088584 |
0.637 |
|
| 2014 |
Fu ZD, Klaassen CD. Short-term calorie restriction feminizes the mRNA profiles of drug metabolizing enzymes and transporters in livers of mice. Toxicology and Applied Pharmacology. 274: 137-46. PMID 24240088 DOI: 10.1016/J.Taap.2013.11.003 |
0.495 |
|
| 2014 |
Liu K, Li F, Lu J, Gao Z, Klaassen CD, Ma X. Role of CYP3A in isoniazid metabolism in vivo. Drug Metabolism and Pharmacokinetics. 29: 219-22. PMID 24172716 DOI: 10.2133/Dmpk.Dmpk-13-Nt-089 |
0.48 |
|
| 2014 |
Klaassen CD. Learning to program the liver. Annual Review of Pharmacology and Toxicology. 54: 1-8. PMID 24160704 DOI: 10.1146/Annurev-Pharmtox-011112-140312 |
0.444 |
|
| 2013 |
Rockwell CE, Turley AE, Cheng X, Fields PE, Klaassen CD. Acute Immunotoxic Effects of Perfluorononanoic Acid (PFNA) in C57BL/6 Mice. Clinical & Experimental Pharmacology. PMID 25568816 DOI: 10.4172/2161-1459.S4-002 |
0.71 |
|
| 2013 |
Fu ZD, Klaassen CD. Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice. Toxicology and Applied Pharmacology. 273: 680-90. PMID 24183703 DOI: 10.1016/J.Taap.2013.10.020 |
0.421 |
|
| 2013 |
Peng L, Cui JY, Yoo B, Gunewardena SS, Lu H, Klaassen CD, Zhong XB. RNA-sequencing quantification of hepatic ontogeny of phase-I enzymes in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 2175-86. PMID 24080161 DOI: 10.1124/Dmd.113.054635 |
0.684 |
|
| 2013 |
Liu J, Lu YF, Zhang Y, Wu KC, Fan F, Klaassen CD. Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice. Toxicology and Applied Pharmacology. 272: 816-24. PMID 23948738 DOI: 10.1016/J.Taap.2013.08.003 |
0.737 |
|
| 2013 |
Liu J, Wu KC, Lu YF, Ekuase E, Klaassen CD. Nrf2 protection against liver injury produced by various hepatotoxicants. Oxidative Medicine and Cellular Longevity. 2013: 305861. PMID 23766851 DOI: 10.1155/2013/305861 |
0.438 |
|
| 2013 |
Zhang Y, Csanaky IL, Selwyn FP, Lehman-McKeeman LD, Klaassen CD. Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism. Biochemical Pharmacology. 86: 437-45. PMID 23747753 DOI: 10.1016/J.Bcp.2013.05.020 |
0.75 |
|
| 2013 |
Zhang Y, Klaassen CD. Hormonal regulation of Cyp4a isoforms in mouse liver and kidney. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 43: 1055-63. PMID 23725209 DOI: 10.3109/00498254.2013.797622 |
0.724 |
|
| 2013 |
Pratt-Hyatt M, Lickteig AJ, Klaassen CD. Tissue distribution, ontogeny, and chemical induction of aldo-keto reductases in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1480-7. PMID 23660342 DOI: 10.1124/Dmd.113.051904 |
0.84 |
|
| 2013 |
Zhang YK, Wu KC, Klaassen CD. Genetic activation of Nrf2 protects against fasting-induced oxidative stress in livers of mice. Plos One. 8: e59122. PMID 23527105 DOI: 10.1371/Journal.Pone.0059122 |
0.719 |
|
| 2013 |
Li F, Lu J, Cheng J, Wang L, Matsubara T, Csanaky IL, Klaassen CD, Gonzalez FJ, Ma X. Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy. Nature Medicine. 19: 418-20. PMID 23475203 DOI: 10.1038/Nm.3104 |
0.376 |
|
| 2013 |
Lu H, Gunewardena S, Cui JY, Yoo B, Zhong XB, Klaassen CD. RNA-sequencing quantification of hepatic ontogeny and tissue distribution of mRNAs of phase II enzymes in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 844-57. PMID 23382457 DOI: 10.1124/Dmd.112.050211 |
0.679 |
|
| 2013 |
Reisman SA, Ward KW, Klaassen CD, Meyer CJ. CDDO-9,11-dihydro-trifluoroethyl amide (CDDO-dhTFEA) induces hepatic cytoprotective genes and increases bile flow in rats. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 43: 571-8. PMID 23244591 DOI: 10.3109/00498254.2012.750022 |
0.779 |
|
| 2013 |
Zhang YK, Lu H, Klaassen CD. Expression of human CAR splicing variants in BAC-transgenic mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 132: 142-50. PMID 23152187 DOI: 10.1093/Toxsci/Kfs321 |
0.74 |
|
| 2012 |
Wu KC, McDonald PR, Liu JJ, Chaguturu R, Klaassen CD. Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway. Plos One. 7: e44686. PMID 23056183 DOI: 10.1371/Journal.Pone.0044686 |
0.31 |
|
| 2012 |
Zhang YK, Wu KC, Liu J, Klaassen CD. Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet. Toxicology and Applied Pharmacology. 264: 305-14. PMID 23017736 DOI: 10.1016/J.Taap.2012.09.014 |
0.707 |
|
| 2012 |
Xu YQ, Zhang D, Jin T, Cai DJ, Wu Q, Lu Y, Liu J, Klaassen CD. Diurnal variation of hepatic antioxidant gene expression in mice. Plos One. 7: e44237. PMID 22952936 DOI: 10.1371/Journal.Pone.0044237 |
0.473 |
|
| 2012 |
Aleksunes LM, Yeager RL, Wen X, Cui JY, Klaassen CD. Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy. Toxicological Sciences : An Official Journal of the Society of Toxicology. 130: 257-68. PMID 22903823 DOI: 10.1093/Toxsci/Kfs248 |
0.707 |
|
| 2012 |
Wu KC, Cui JY, Klaassen CD. Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. Plos One. 7: e39006. PMID 22808024 DOI: 10.1371/Journal.Pone.0039006 |
0.703 |
|
| 2012 |
Lu H, Cui JY, Gunewardena S, Yoo B, Zhong XB, Klaassen CD. Hepatic ontogeny and tissue distribution of mRNAs of epigenetic modifiers in mice using RNA-sequencing. Epigenetics. 7: 914-29. PMID 22772165 DOI: 10.4161/Epi.21113 |
0.697 |
|
| 2012 |
Wu KC, Zhang Y, Klaassen CD. Nrf2 protects against diquat-induced liver and lung injury. Free Radical Research. 46: 1220-9. PMID 22762311 DOI: 10.3109/10715762.2012.700709 |
0.694 |
|
| 2012 |
Wu KC, Liu JJ, Klaassen CD. Nrf2 activation prevents cadmium-induced acute liver injury. Toxicology and Applied Pharmacology. 263: 14-20. PMID 22677785 DOI: 10.1016/J.Taap.2012.05.017 |
0.503 |
|
| 2012 |
Cheng X, Klaassen CD. Hormonal and chemical regulation of paraoxonases in mice. The Journal of Pharmacology and Experimental Therapeutics. 342: 688-95. PMID 22653878 DOI: 10.1124/Jpet.112.194803 |
0.772 |
|
| 2012 |
Wu KC, Liu J, Klaassen CD. Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. Toxicology and Applied Pharmacology. 262: 321-9. PMID 22627062 DOI: 10.1016/J.Taap.2012.05.010 |
0.476 |
|
| 2012 |
Kong B, Csanaky IL, Aleksunes LM, Patni M, Chen Q, Ma X, Jaeschke H, Weir S, Broward M, Klaassen CD, Guo GL. Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity. Toxicology and Applied Pharmacology. 261: 189-95. PMID 22521610 DOI: 10.1016/J.Taap.2012.04.001 |
0.495 |
|
| 2012 |
Zhang Y, Limaye PB, Lehman-McKeeman LD, Klaassen CD. Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice. Plos One. 7: e34522. PMID 22496825 DOI: 10.1371/Journal.Pone.0034522 |
0.725 |
|
| 2012 |
Aleksunes LM, Klaassen CD. Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1366-79. PMID 22496397 DOI: 10.1124/Dmd.112.045112 |
0.504 |
|
| 2012 |
Kong B, Wang L, Chiang JY, Zhang Y, Klaassen CD, Guo GL. Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology (Baltimore, Md.). 56: 1034-43. PMID 22467244 DOI: 10.1002/Hep.25740 |
0.7 |
|
| 2012 |
Zhang Y, Csanaky IL, Cheng X, Lehman-McKeeman LD, Klaassen CD. Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 127: 451-62. PMID 22461449 DOI: 10.1093/Toxsci/Kfs123 |
0.825 |
|
| 2012 |
Cui JY, Gunewardena SS, Yoo B, Liu J, Renaud HJ, Lu H, Zhong XB, Klaassen CD. RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development. Toxicological Sciences : An Official Journal of the Society of Toxicology. 127: 592-608. PMID 22454430 DOI: 10.1093/Toxsci/Kfs107 |
0.689 |
|
| 2012 |
Cui JY, Renaud HJ, Klaassen CD. Ontogeny of novel cytochrome P450 gene isoforms during postnatal liver maturation in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1226-37. PMID 22446519 DOI: 10.1124/Dmd.111.042697 |
0.626 |
|
| 2012 |
Fu ZD, Csanaky IL, Klaassen CD. Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1216-25. PMID 22446518 DOI: 10.1124/Dmd.111.044461 |
0.453 |
|
| 2012 |
Peng L, Yoo B, Gunewardena SS, Lu H, Klaassen CD, Zhong XB. RNA sequencing reveals dynamic changes of mRNA abundance of cytochromes P450 and their alternative transcripts during mouse liver development. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1198-209. PMID 22434873 DOI: 10.1124/Dmd.112.045088 |
0.442 |
|
| 2012 |
Zhang Y, Cheng X, Aleksunes L, Klaassen CD. Transcription factor-mediated regulation of carboxylesterase enzymes in livers of mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1191-7. PMID 22429928 DOI: 10.1124/Dmd.111.043877 |
0.824 |
|
| 2012 |
Fu ZD, Csanaky IL, Klaassen CD. Gender-divergent profile of bile acid homeostasis during aging of mice. Plos One. 7: e32551. PMID 22403674 DOI: 10.1371/Journal.Pone.0032551 |
0.503 |
|
| 2012 |
Cui JY, Aleksunes LM, Tanaka Y, Fu ZD, Guo Y, Guo GL, Lu H, Zhong XB, Klaassen CD. Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G979-96. PMID 22268101 DOI: 10.1152/Ajpgi.00370.2011 |
0.742 |
|
| 2012 |
Haeusler RA, Pratt-Hyatt M, Welch CL, Klaassen CD, Accili D. Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metabolism. 15: 65-74. PMID 22197325 DOI: 10.1016/J.Cmet.2011.11.010 |
0.798 |
|
| 2012 |
Martin LA, Wilson DT, Reuhl KR, Gallo MA, Klaassen CD. Polychlorinated biphenyl congeners that increase the glucuronidation and biliary excretion of thyroxine are distinct from the congeners that enhance the serum disappearance of thyroxine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 588-95. PMID 22187485 DOI: 10.1124/Dmd.111.042796 |
0.305 |
|
| 2012 |
Li T, Francl JM, Boehme S, Ochoa A, Zhang Y, Klaassen CD, Erickson SK, Chiang JY. Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity. The Journal of Biological Chemistry. 287: 1861-73. PMID 22144677 DOI: 10.1074/Jbc.M111.305789 |
0.665 |
|
| 2012 |
Zhang Y, Hong JY, Rockwell CE, Copple BL, Jaeschke H, Klaassen CD. Effect of bile duct ligation on bile acid composition in mouse serum and liver. Liver International : Official Journal of the International Association For the Study of the Liver. 32: 58-69. PMID 22098667 DOI: 10.1111/J.1478-3231.2011.02662.X |
0.663 |
|
| 2012 |
Selwyn F, Klaassen CD. Characterization of Bile Acid homeostasis in Germ-free Mice The Faseb Journal. 26. DOI: 10.1096/Fasebj.26.1_Supplement.1155.1 |
0.353 |
|
| 2011 |
Renaud HJ, Cui JY, Khan M, Klaassen CD. Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 124: 261-77. PMID 21920951 DOI: 10.1093/Toxsci/Kfr240 |
0.686 |
|
| 2011 |
Guo Y, Pope C, Cheng X, Zhou H, Klaassen CD. Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice. Journal of Ethnopharmacology. 138: 111-8. PMID 21920422 DOI: 10.1016/J.Jep.2011.08.058 |
0.689 |
|
| 2011 |
Zhang Y, Csanaky IL, Lehman-McKeeman LD, Klaassen CD. Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability. Toxicological Sciences : An Official Journal of the Society of Toxicology. 124: 251-60. PMID 21914718 DOI: 10.1093/Toxsci/Kfr236 |
0.706 |
|
| 2011 |
Pacyniak E, Hagenbuch B, Klaassen CD, Lehman-McKeeman L, Guo GL. Organic anion transporting polypeptides in the hepatic uptake of PBDE congeners in mice. Toxicology and Applied Pharmacology. 257: 23-31. PMID 21884716 DOI: 10.1016/J.Taap.2011.08.014 |
0.482 |
|
| 2011 |
Lu H, Cui W, Klaassen CD. Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis. Toxicology and Applied Pharmacology. 256: 122-35. PMID 21846477 DOI: 10.1016/J.Taap.2011.07.019 |
0.527 |
|
| 2011 |
Guo Y, Li F, Ma X, Cheng X, Zhou H, Klaassen CD. CYP2D plays a major role in berberine metabolism in liver of mice and humans. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 41: 996-1005. PMID 21787170 DOI: 10.3109/00498254.2011.597456 |
0.709 |
|
| 2011 |
Wu KC, Cui JY, Klaassen CD. Beneficial role of Nrf2 in regulating NADPH generation and consumption. Toxicological Sciences : An Official Journal of the Society of Toxicology. 123: 590-600. PMID 21775727 DOI: 10.1093/Toxsci/Kfr183 |
0.694 |
|
| 2011 |
Song P, Zhang Y, Klaassen CD. Dose-response of five bile acids on serum and liver bile Acid concentrations and hepatotoxicty in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 123: 359-67. PMID 21747115 DOI: 10.1093/Toxsci/Kfr177 |
0.818 |
|
| 2011 |
Gong L, Aranibar N, Han YH, Zhang Y, Lecureux L, Bhaskaran V, Khandelwal P, Klaassen CD, Lehman-McKeeman LD. Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles Toxicological Sciences. 122: 587-597. PMID 21561886 DOI: 10.1093/Toxsci/Kfr114 |
0.707 |
|
| 2011 |
Klaassen CD, Lu H, Cui JY. Epigenetic regulation of drug processing genes. Toxicology Mechanisms and Methods. 21: 312-24. PMID 21495869 DOI: 10.3109/15376516.2011.562758 |
0.633 |
|
| 2011 |
Zhang YK, Guo GL, Klaassen CD. Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters. Plos One. 6: e16683. PMID 21346810 DOI: 10.1371/Journal.Pone.0016683 |
0.671 |
|
| 2011 |
Alnouti Y, Klaassen CD. Mechanisms of gender-specific regulation of mouse sulfotransferases (Sults). Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 41: 187-97. PMID 21091322 DOI: 10.3109/00498254.2010.535923 |
0.428 |
|
| 2011 |
Csanaky IL, Lu H, Zhang Y, Ogura K, Choudhuri S, Klaassen CD. Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice. Hepatology (Baltimore, Md.). 53: 272-81. PMID 20949553 DOI: 10.1002/Hep.23984 |
0.747 |
|
| 2010 |
Lu H, Gonzalez FJ, Klaassen C. Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. Toxicological Sciences : An Official Journal of the Society of Toxicology. 118: 380-90. PMID 20935164 DOI: 10.1093/Toxsci/Kfq280 |
0.507 |
|
| 2010 |
Cui JY, Gunewardena SS, Rockwell CE, Klaassen CD. ChIPing the cistrome of PXR in mouse liver. Nucleic Acids Research. 38: 7943-63. PMID 20693526 DOI: 10.1093/Nar/Gkq654 |
0.642 |
|
| 2010 |
Zhang Y, Klaassen CD. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. Journal of Lipid Research. 51: 3230-42. PMID 20671298 DOI: 10.1194/Jlr.M007641 |
0.672 |
|
| 2010 |
Richardson TA, Klaassen CD. Disruption of thyroid hormone homeostasis in Ugt1a-deficient Gunn rats by microsomal enzyme inducers is not due to enhanced thyroxine glucuronidation. Toxicology and Applied Pharmacology. 248: 38-44. PMID 20655938 DOI: 10.1016/J.Taap.2010.07.010 |
0.313 |
|
| 2010 |
Aleksunes LM, Goedken MJ, Rockwell CE, Thomale J, Manautou JE, Klaassen CD. Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity. The Journal of Pharmacology and Experimental Therapeutics. 335: 2-12. PMID 20605904 DOI: 10.1124/Jpet.110.170084 |
0.44 |
|
| 2010 |
Martin L, Klaassen CD. Differential effects of polychlorinated biphenyl congeners on serum thyroid hormone levels in rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 117: 36-44. PMID 20573785 DOI: 10.1093/Toxsci/Kfq187 |
0.35 |
|
| 2010 |
Copple BL, Jaeschke H, Klaassen CD. Oxidative stress and the pathogenesis of cholestasis. Seminars in Liver Disease. 30: 195-204. PMID 20422501 DOI: 10.1055/S-0030-1253228 |
0.358 |
|
| 2010 |
Richardson TA, Klaassen CD. Role of UDP-glucuronosyltransferase (UGT) 2B2 in metabolism of triiodothyronine: effect of microsomal enzyme inducers in Sprague Dawley and UGT2B2-deficient Fischer 344 rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 116: 413-21. PMID 20421340 DOI: 10.1093/Toxsci/Kfq125 |
0.318 |
|
| 2010 |
Cui JY, Choudhuri S, Knight TR, Klaassen CD. Genetic and epigenetic regulation and expression signatures of glutathione S-transferases in developing mouse liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. 116: 32-43. PMID 20395309 DOI: 10.1093/Toxsci/Kfq115 |
0.682 |
|
| 2010 |
Zhang YK, Saupe KW, Klaassen CD. Energy restriction does not compensate for the reduced expression of hepatic drug-processing genes in mice with aging. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 1122-31. PMID 20382754 DOI: 10.1124/Dmd.110.032599 |
0.726 |
|
| 2010 |
Zhang YK, Yeager RL, Tanaka Y, Klaassen CD. Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. Toxicology and Applied Pharmacology. 245: 326-34. PMID 20350562 DOI: 10.1016/J.Taap.2010.03.016 |
0.732 |
|
| 2010 |
Staudinger JL, Xu C, Cui YJ, Klaassen CD. Nuclear receptor-mediated regulation of carboxylesterase expression and activity. Expert Opinion On Drug Metabolism & Toxicology. 6: 261-71. PMID 20163318 DOI: 10.1517/17425250903483215 |
0.375 |
|
| 2010 |
Klaassen CD, Reisman SA. Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver. Toxicology and Applied Pharmacology. 244: 57-65. PMID 20122946 DOI: 10.1016/J.Taap.2010.01.013 |
0.79 |
|
| 2010 |
Klaassen CD, Aleksunes LM. Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacological Reviews. 62: 1-96. PMID 20103563 DOI: 10.1124/Pr.109.002014 |
0.34 |
|
| 2010 |
Aleksunes LM, Reisman SA, Yeager RL, Goedken MJ, Klaassen CD. Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice. The Journal of Pharmacology and Experimental Therapeutics. 333: 140-51. PMID 20086057 DOI: 10.1124/Jpet.109.162271 |
0.764 |
|
| 2010 |
Lu H, Li Y, Zhong X, Klaassen CD. Abstract 4865: Inhibition of histone methyltransferase G9a as a promising new target for the treatment of liver cancer Cancer Research. 70: 4865-4865. DOI: 10.1158/1538-7445.Am10-4865 |
0.369 |
|
| 2009 |
Ren H, Aleksunes LM, Wood C, Vallanat B, George MH, Klaassen CD, Corton JC. Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor. Toxicological Sciences : An Official Journal of the Society of Toxicology. 113: 45-59. PMID 19850644 DOI: 10.1093/Toxsci/Kfp251 |
0.491 |
|
| 2009 |
Cheng X, Klaassen CD. Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 2178-85. PMID 19679677 DOI: 10.1124/Dmd.109.027177 |
0.721 |
|
| 2009 |
Li Y, Buckley D, Wang S, Klaassen CD, Zhong XB. Genetic polymorphisms in the TATA box and upstream phenobarbital-responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 1978-86. PMID 19541828 DOI: 10.1124/Dmd.109.027409 |
0.605 |
|
| 2009 |
Csanaky IL, Aleksunes LM, Tanaka Y, Klaassen CD. Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 297: G419-33. PMID 19497955 DOI: 10.1152/Ajpgi.90728.2008 |
0.52 |
|
| 2009 |
Cui YJ, Yeager RL, Zhong XB, Klaassen CD. Ontogenic expression of hepatic Ahr mRNA is associated with histone H3K4 di-methylation during mouse liver development. Toxicology Letters. 189: 184-90. PMID 19481593 DOI: 10.1016/J.Toxlet.2009.05.017 |
0.44 |
|
| 2009 |
Aleksunes LM, Yeager RL, Klaassen CD. Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers Xenobiotica. 39: 514-522. PMID 19480556 DOI: 10.1080/00498250902952514 |
0.423 |
|
| 2009 |
Yeager RL, Reisman SA, Aleksunes LM, Klaassen CD. Introducing the "TCDD-inducible AhR-Nrf2 gene battery". Toxicological Sciences : An Official Journal of the Society of Toxicology. 111: 238-46. PMID 19474220 DOI: 10.1093/Toxsci/Kfp115 |
0.776 |
|
| 2009 |
Beilke LD, Aleksunes LM, Olson ER, Besselsen DG, Klaassen CD, Dvorak K, Cherrington NJ. Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice. Toxicology Letters. 188: 38-44. PMID 19433268 DOI: 10.1016/J.Toxlet.2009.03.005 |
0.482 |
|
| 2009 |
Cui YJ, Aleksunes LM, Tanaka Y, Goedken MJ, Klaassen CD. Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 110: 47-60. PMID 19407337 DOI: 10.1093/Toxsci/Kfp094 |
0.555 |
|
| 2009 |
Reisman SA, Buckley DB, Tanaka Y, Klaassen CD. CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes. Toxicology and Applied Pharmacology. 236: 109-14. PMID 19371629 DOI: 10.1016/J.Taap.2008.12.024 |
0.83 |
|
| 2009 |
Klaassen CD, Liu J, Diwan BA. Metallothionein protection of cadmium toxicity. Toxicology and Applied Pharmacology. 238: 215-20. PMID 19362100 DOI: 10.1016/J.Taap.2009.03.026 |
0.308 |
|
| 2009 |
Reisman SA, Aleksunes LM, Klaassen CD. Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Biochemical Pharmacology. 77: 1273-82. PMID 19283895 DOI: 10.1016/J.Bcp.2008.12.028 |
0.775 |
|
| 2009 |
Reisman SA, Csanaky IL, Aleksunes LM, Klaassen CD. Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 109: 31-40. PMID 19246624 DOI: 10.1093/Toxsci/Kfp047 |
0.798 |
|
| 2009 |
Reisman SA, Csanaky IL, Yeager RL, Klaassen CD. Nrf2 activation enhances biliary excretion of sulfobromophthalein by inducing glutathione-S-transferase activity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 109: 24-30. PMID 19246623 DOI: 10.1093/Toxsci/Kfp045 |
0.815 |
|
| 2009 |
Lecureux L, Dieter MZ, Nelson DM, Watson L, Wong H, Gemzik B, Klaassen CD, Lehman-McKeeman LD. Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism. Toxicological Sciences : An Official Journal of the Society of Toxicology. 108: 482-91. PMID 19211616 DOI: 10.1093/Toxsci/Kfp026 |
0.334 |
|
| 2009 |
Beilke LD, Aleksunes LM, Holland RD, Besselsen DG, Beger RD, Klaassen CD, Cherrington NJ. Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 1035-45. PMID 19196849 DOI: 10.1124/Dmd.108.023317 |
0.489 |
|
| 2009 |
Li Y, Cui Y, Hart SN, Klaassen CD, Zhong XB. Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation. Molecular Pharmacology. 75: 1171-9. PMID 19188337 DOI: 10.1124/Mol.108.052993 |
0.43 |
|
| 2009 |
Tanaka Y, Aleksunes LM, Cui YJ, Klaassen CD. ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling. Toxicological Sciences : An Official Journal of the Society of Toxicology. 108: 247-57. PMID 19181614 DOI: 10.1093/Toxsci/Kfp020 |
0.524 |
|
| 2009 |
Yang X, Zhang YK, Esterly N, Klaassen CD, Wan YJ. Gender disparity of hepatic lipid homoeostasis regulated by the circadian clock. Journal of Biochemistry. 145: 609-23. PMID 19174548 DOI: 10.1093/Jb/Mvp018 |
0.678 |
|
| 2009 |
Buckley DB, Klaassen CD. Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 847-56. PMID 19144771 DOI: 10.1124/Dmd.108.024190 |
0.689 |
|
| 2009 |
Buckley DB, Klaassen CD. Mechanism of gender-divergent UDP-glucuronosyltransferase mRNA expression in mouse liver and kidney. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 834-40. PMID 19131521 DOI: 10.1124/Dmd.108.024224 |
0.701 |
|
| 2009 |
Reisman SA, Yeager RL, Yamamoto M, Klaassen CD. Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species. Toxicological Sciences : An Official Journal of the Society of Toxicology. 108: 35-47. PMID 19129213 DOI: 10.1093/Toxsci/Kfn267 |
0.79 |
|
| 2009 |
Gyamfi MA, Tanaka Y, He L, Klaassen CD, Wan YJ. Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice. Toxicology and Applied Pharmacology. 234: 166-78. PMID 18952117 DOI: 10.1016/J.Taap.2008.09.022 |
0.529 |
|
| 2009 |
Cui YJ, Cheng X, Weaver YM, Klaassen CD. Tissue distribution, gender-divergent expression, ontogeny, and chemical induction of multidrug resistance transporter genes (Mdr1a, Mdr1b, Mdr2) in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 203-10. PMID 18854377 DOI: 10.1124/Dmd.108.023721 |
0.752 |
|
| 2009 |
Zhang YK, Yeager RL, Klaassen CD. Circadian expression profiles of drug-processing genes and transcription factors in mouse liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 106-15. PMID 18838502 DOI: 10.1124/Dmd.108.024174 |
0.718 |
|
| 2008 |
Hart SN, Cui Y, Klaassen CD, Zhong XB. Three patterns of cytochrome P450 gene expression during liver maturation in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 116-21. PMID 18845660 DOI: 10.1124/Dmd.108.023812 |
0.458 |
|
| 2008 |
Alnouti Y, Csanaky IL, Klaassen CD. Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 873: 209-17. PMID 18801708 DOI: 10.1016/J.Jchromb.2008.08.018 |
0.373 |
|
| 2008 |
Maher JM, Aleksunes LM, Dieter MZ, Tanaka Y, Peters JM, Manautou JE, Klaassen CD. Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid. Toxicological Sciences : An Official Journal of the Society of Toxicology. 106: 319-28. PMID 18757529 DOI: 10.1093/Toxsci/Kfn177 |
0.748 |
|
| 2008 |
Knight TR, Choudhuri S, Klaassen CD. Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers. Toxicological Sciences : An Official Journal of the Society of Toxicology. 106: 329-38. PMID 18723825 DOI: 10.1093/Toxsci/Kfn179 |
0.475 |
|
| 2008 |
Cheng X, Klaassen CD. Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers. Toxicological Sciences : An Official Journal of the Society of Toxicology. 106: 37-45. PMID 18703564 DOI: 10.1093/Toxsci/Kfn161 |
0.755 |
|
| 2008 |
Cheng X, Klaassen CD. Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors. Toxicological Sciences : An Official Journal of the Society of Toxicology. 106: 29-36. PMID 18648086 DOI: 10.1093/Toxsci/Kfn147 |
0.742 |
|
| 2008 |
Tanaka Y, Aleksunes LM, Goedken MJ, Chen C, Reisman SA, Manautou JE, Klaassen CD. Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity. Toxicology and Applied Pharmacology. 231: 364-73. PMID 18617210 DOI: 10.1016/J.Taap.2008.05.022 |
0.77 |
|
| 2008 |
Lickteig AJ, Cheng X, Augustine LM, Klaassen CD, Cherrington NJ. Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice. Life Sciences. 83: 59-64. PMID 18573474 DOI: 10.1016/J.Lfs.2008.05.004 |
0.726 |
|
| 2008 |
Aleksunes LM, Cui Y, Klaassen CD. Prominent expression of xenobiotic efflux transporters in mouse extraembryonic fetal membranes compared with placenta. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1960-70. PMID 18566041 DOI: 10.1124/Dmd.108.021337 |
0.362 |
|
| 2008 |
Merrell MD, Jackson JP, Augustine LM, Fisher CD, Slitt AL, Maher JM, Huang W, Moore DD, Zhang Y, Klaassen CD, Cherrington NJ. The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1716-21. PMID 18474683 DOI: 10.1124/Dmd.108.020867 |
0.832 |
|
| 2008 |
Lu H, Choudhuri S, Ogura K, Csanaky IL, Lei X, Cheng X, Song PZ, Klaassen CD. Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicological Sciences : An Official Journal of the Society of Toxicology. 103: 35-45. PMID 18296417 DOI: 10.1093/Toxsci/Kfn038 |
0.827 |
|
| 2008 |
Tanaka Y, Aleksunes LM, Yeager RL, Gyamfi MA, Esterly N, Guo GL, Klaassen CD. NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet. The Journal of Pharmacology and Experimental Therapeutics. 325: 655-64. PMID 18281592 DOI: 10.1124/Jpet.107.135822 |
0.503 |
|
| 2008 |
Tanaka Y, Chen C, Maher JM, Klaassen CD. Ischemia-reperfusion of rat livers decreases liver and increases kidney multidrug resistance associated protein 2 (Mrp2). Toxicological Sciences : An Official Journal of the Society of Toxicology. 101: 171-8. PMID 17959626 DOI: 10.1093/Toxsci/Kfm261 |
0.744 |
|
| 2008 |
Aleksunes LM, Slitt AL, Maher JM, Augustine LM, Goedken MJ, Chan JY, Cherrington NJ, Klaassen CD, Manautou JE. Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2. Toxicology and Applied Pharmacology. 226: 74-83. PMID 17935745 DOI: 10.1016/J.Taap.2007.08.022 |
0.77 |
|
| 2007 |
Alnouti Y, Klaassen CD. Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 101: 51-64. PMID 17998271 DOI: 10.1093/Toxsci/Kfm280 |
0.431 |
|
| 2007 |
Alnouti Y, Klaassen CD. Regulation of sulfotransferase enzymes by prototypical microsomal enzyme inducers in mice. The Journal of Pharmacology and Experimental Therapeutics. 324: 612-21. PMID 17993606 DOI: 10.1124/Jpet.107.129650 |
0.479 |
|
| 2007 |
Cheng X, Buckley D, Klaassen CD. Regulation of hepatic bile acid transporters Ntcp and Bsep expression. Biochemical Pharmacology. 74: 1665-76. PMID 17897632 DOI: 10.1016/J.Bcp.2007.08.014 |
0.83 |
|
| 2007 |
Knight TR, Choudhuri S, Klaassen CD. Constitutive mRNA expression of various glutathione S-transferase isoforms in different tissues of mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 100: 513-24. PMID 17890767 DOI: 10.1093/Toxsci/Kfm233 |
0.428 |
|
| 2007 |
Lu H, Klaassen C. Gender differences in mRNA expression of ATP-binding cassette efflux and bile acid transporters in kidney, liver, and intestine of 5/6 nephrectomized rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 16-23. PMID 17855625 DOI: 10.1124/Dmd.107.014845 |
0.444 |
|
| 2007 |
Klaassen CD, Lu H. Xenobiotic transporters: ascribing function from gene knockout and mutation studies. Toxicological Sciences : An Official Journal of the Society of Toxicology. 101: 186-96. PMID 17698509 DOI: 10.1093/Toxsci/Kfm214 |
0.353 |
|
| 2007 |
Maher JM, Dieter MZ, Aleksunes LM, Slitt AL, Guo G, Tanaka Y, Scheffer GL, Chan JY, Manautou JE, Chen Y, Dalton TP, Yamamoto M, Klaassen CD. Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology (Baltimore, Md.). 46: 1597-610. PMID 17668877 DOI: 10.1002/Hep.21831 |
0.743 |
|
| 2007 |
Petrick JS, Klaassen CD. Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 1806-15. PMID 17627975 DOI: 10.1124/Dmd.107.015974 |
0.506 |
|
| 2007 |
Fisher CD, Augustine LM, Maher JM, Nelson DM, Slitt AL, Klaassen CD, Lehman-McKeeman LD, Cherrington NJ. Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 995-1000. PMID 17353348 DOI: 10.1124/Dmd.106.014340 |
0.731 |
|
| 2007 |
Pacyniak EK, Cheng X, Cunningham ML, Crofton K, Klaassen CD, Guo GL. The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators. Toxicological Sciences : An Official Journal of the Society of Toxicology. 97: 94-102. PMID 17324954 DOI: 10.1093/Toxsci/Kfm025 |
0.699 |
|
| 2007 |
Alnouti YM, Shelby MK, Chen C, Klaassen CD. Influence of phenobarbital on morphine metabolism and disposition: LC-MS/MS determination of morphine (M) and morphine-3-glucuronide (M3G) in Wistar-Kyoto rat serum, bile, and urine. Current Drug Metabolism. 8: 79-89. PMID 17266525 DOI: 10.2174/138920007779315026 |
0.773 |
|
| 2007 |
Chen C, Cheng X, Dieter MZ, Tanaka Y, Klaassen CD. Activation of cAMP-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 expression. Molecular Pharmacology. 71: 1159-64. PMID 17244698 DOI: 10.1124/Mol.106.030841 |
0.712 |
|
| 2007 |
Moffit JS, Aleksunes LM, Kardas MJ, Slitt AL, Klaassen CD, Manautou JE. Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen. Toxicology. 230: 197-206. PMID 17188792 DOI: 10.1016/J.Tox.2006.11.052 |
0.443 |
|
| 2007 |
Tanaka Y, Maher JM, Chen C, Klaassen CD. Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. Molecular Pharmacology. 71: 817-25. PMID 17151289 DOI: 10.1124/Mol.106.029033 |
0.735 |
|
| 2007 |
Slitt AL, Allen K, Morrone J, Aleksunes LM, Chen C, Maher JM, Manautou JE, Cherrington NJ, Klaassen CD. Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. Biochimica Et Biophysica Acta. 1768: 637-47. PMID 17141734 DOI: 10.1016/J.Bbamem.2006.10.008 |
0.775 |
|
| 2007 |
Buckley DB, Klaassen CD. Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 121-7. PMID 17050650 DOI: 10.1124/Dmd.106.012070 |
0.696 |
|
| 2006 |
Aleksunes LM, Slitt AL, Maher JM, Dieter MZ, Knight TR, Goedken M, Cherrington NJ, Chan JY, Klaassen CD, Manautou JE. Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis. Cell Stress & Chaperones. 11: 356-63. PMID 17278884 DOI: 10.1379/Csc-217.1 |
0.772 |
|
| 2006 |
Kim DW, Kim KY, Choi BS, Youn P, Ryu DY, Klaassen CD, Park JD. Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake. Archives of Toxicology. 81: 327-34. PMID 17031680 DOI: 10.1007/S00204-006-0160-7 |
0.319 |
|
| 2006 |
Lu H, Lei X, Klaassen C. Gender differences in renal nuclear receptors and aryl hydrocarbon receptor in 5/6 nephrectomized rats Kidney International. 70: 1920-1928. PMID 16985511 DOI: 10.1038/Sj.Ki.5001880 |
0.329 |
|
| 2006 |
Cheng X, Klaassen CD. Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1863-7. PMID 16928788 DOI: 10.1124/Dmd.106.010520 |
0.776 |
|
| 2006 |
Tanaka Y, Chen C, Maher JM, Klaassen CD. Kupffer cell-mediated downregulation of hepatic transporter expression in rat hepatic ischemia-reperfusion. Transplantation. 82: 258-66. PMID 16858290 DOI: 10.1097/01.Tp.0000226243.69023.54 |
0.709 |
|
| 2006 |
Shelby MK, Klaassen CD. Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1772-8. PMID 16855052 DOI: 10.1124/Dmd.106.010397 |
0.832 |
|
| 2006 |
Choudhuri S, Klaassen CD. Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. International Journal of Toxicology. 25: 231-59. PMID 16815813 DOI: 10.1080/10915810600746023 |
0.343 |
|
| 2006 |
Cheng X, Maher J, Lu H, Klaassen CD. Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression. Molecular Pharmacology. 70: 1291-7. PMID 16807376 DOI: 10.1124/Mol.106.025122 |
0.831 |
|
| 2006 |
Alnouti Y, Klaassen CD. Tissue distribution and ontogeny of sulfotransferase enzymes in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 93: 242-55. PMID 16807285 DOI: 10.1093/Toxsci/Kfl050 |
0.448 |
|
| 2006 |
Maher JM, Slitt AL, Callaghan TN, Cheng X, Cheung C, Gonzalez FJ, Klaassen CD. Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha. Biochemical Pharmacology. 72: 512-22. PMID 16806085 DOI: 10.1016/J.Bcp.2006.03.016 |
0.832 |
|
| 2006 |
Nakamoto K, Wang S, Jenison RD, Guo GL, Klaassen CD, Wan YJ, Zhong XB. Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene. Bmc Genetics. 7: 29. PMID 16709249 DOI: 10.1186/1471-2156-7-29 |
0.302 |
|
| 2006 |
Slitt AL, Cherrington NJ, Fisher CD, Negishi M, Klaassen CD. Induction of genes for metabolism and transport by trans-stilbene oxide in livers of Sprague-Dawley and Wistar-Kyoto rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1190-7. PMID 16621935 DOI: 10.1124/Dmd.105.007542 |
0.507 |
|
| 2006 |
Maher JM, Cheng X, Tanaka Y, Scheffer GL, Klaassen CD. Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice. Biochemical Pharmacology. 71: 1470-8. PMID 16529719 DOI: 10.1016/J.Bcp.2006.02.005 |
0.81 |
|
| 2006 |
Moffit JS, Aleksunes LM, Maher JM, Scheffer GL, Klaassen CD, Manautou JE. Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha. The Journal of Pharmacology and Experimental Therapeutics. 317: 537-45. PMID 16467456 DOI: 10.1124/Jpet.105.093765 |
0.763 |
|
| 2006 |
Slitt AL, Cherrington NJ, Dieter MZ, Aleksunes LM, Scheffer GL, Huang W, Moore DD, Klaassen CD. trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors. Molecular Pharmacology. 69: 1554-63. PMID 16449384 DOI: 10.1124/Mol.105.014571 |
0.573 |
|
| 2006 |
Maher JM, Cherrington NJ, Slitt AL, Klaassen CD. Tissue distribution and induction of the rat multidrug resistance-associated proteins 5 and 6. Life Sciences. 78: 2219-25. PMID 16260000 DOI: 10.1016/J.Lfs.2005.09.016 |
0.749 |
|
| 2005 |
Alnouti Y, Petrick JS, Klaassen CD. Tissue distribution and ontogeny of organic cation transporters in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 477-82. PMID 16381671 DOI: 10.1124/Dmd.105.006932 |
0.481 |
|
| 2005 |
Lu H, Klaassen C. Tissue distribution and thyroid hormone regulation of Pept1 and Pept2 mRNA in rodents. Peptides. 27: 850-7. PMID 16202478 DOI: 10.1016/J.Peptides.2005.08.012 |
0.426 |
|
| 2005 |
Dai G, Chou N, He L, Gyamfi MA, Mendy AJ, Slitt AL, Klaassen CD, Wan YJ. Retinoid X receptor alpha Regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver. Molecular Pharmacology. 68: 1590-6. PMID 16157696 DOI: 10.1124/Mol.105.013680 |
0.5 |
|
| 2005 |
Klaassen CD, Slitt AL. Regulation of hepatic transporters by xenobiotic receptors. Current Drug Metabolism. 6: 309-28. PMID 16101571 DOI: 10.2174/1389200054633826 |
0.474 |
|
| 2005 |
Chen C, Slitt AL, Dieter MZ, Tanaka Y, Scheffer GL, Klaassen CD. Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR- rats. Biochemical Pharmacology. 70: 1088-95. PMID 16099435 DOI: 10.1016/J.Bcp.2005.06.019 |
0.368 |
|
| 2005 |
Cheng X, Maher J, Dieter MZ, Klaassen CD. Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1276-82. PMID 15919853 DOI: 10.1124/Dmd.105.003988 |
0.83 |
|
| 2005 |
Cheng X, Maher J, Chen C, Klaassen CD. Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps). Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1062-73. PMID 15843488 DOI: 10.1124/Dmd.105.003640 |
0.799 |
|
| 2005 |
Maher JM, Cheng X, Slitt AL, Dieter MZ, Klaassen CD. Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 956-62. PMID 15833929 DOI: 10.1124/Dmd.105.003798 |
0.824 |
|
| 2005 |
Maher JM, Slitt AL, Cherrington NJ, Cheng X, Klaassen CD. Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 947-55. PMID 15802388 DOI: 10.1124/Dmd.105.003780 |
0.826 |
|
| 2005 |
Tanaka Y, Slitt AL, Leazer TM, Maher JM, Klaassen CD. Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice. Biochemical and Biophysical Research Communications. 326: 181-7. PMID 15567169 DOI: 10.1016/J.Bbrc.2004.11.012 |
0.743 |
|
| 2005 |
Aleksunes LM, Slitt AM, Cherrington NJ, Thibodeau MS, Klaassen CD, Manautou JE. Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride. Toxicological Sciences : An Official Journal of the Society of Toxicology. 83: 44-52. PMID 15496496 DOI: 10.1093/Toxsci/Kfi013 |
0.524 |
|
| 2004 |
Dieter MZ, Maher JM, Cheng X, Klaassen CD. Expression and regulation of the sterol half-transporter genes ABCG5 and ABCG8 in rats. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp. 139: 209-18. PMID 15683829 DOI: 10.1016/J.Cca.2004.11.002 |
0.833 |
|
| 2004 |
Li N, Klaassen CD. Lipopolysaccharide-induced down-regulation of organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is independent of tumor necrosis factor-alpha, Interleukin-1beta, interleukin-6, or inducible nitric oxide synthase. Toxicological Sciences : An Official Journal of the Society of Toxicology. 83: 197-203. PMID 15483191 DOI: 10.1093/Toxsci/Kfi003 |
0.343 |
|
| 2004 |
Lu H, Chen C, Klaassen C. Tissue distribution of concentrative and equilibrative nucleoside transporters in male and female rats and mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1455-61. PMID 15371301 DOI: 10.1124/Dmd.104.001123 |
0.477 |
|
| 2004 |
Li N, Klaassen CD. Role of liver-enriched transcription factors in the down-regulation of organic anion transporting polypeptide 4 (oatp4; oatplb2; slc21a10) by lipopolysaccharide. Molecular Pharmacology. 66: 694-701. PMID 15322262 DOI: 10.1124/mol.66.3. |
0.35 |
|
| 2004 |
Cherrington NJ, Slitt AL, Li N, Klaassen CD. Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 734-41. PMID 15205389 DOI: 10.1124/Dmd.32.7.734 |
0.404 |
|
| 2004 |
Vansell NR, Muppidi JR, Habeebu SM, Klaassen CD. Promotion of thyroid tumors in rats by pregnenolone-16alpha-carbonitrile (PCN) and polychlorinated biphenyl (PCB). Toxicological Sciences : An Official Journal of the Society of Toxicology. 81: 50-9. PMID 15201439 DOI: 10.1093/Toxsci/Kfh197 |
0.779 |
|
| 2004 |
Buist SC, Klaassen CD. Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 620-5. PMID 15155553 DOI: 10.1124/Dmd.32.6.620 |
0.829 |
|
| 2004 |
Heijne WH, Slitt AL, van Bladeren PJ, Groten JP, Klaassen CD, Stierum RH, van Ommen B. Bromobenzene-induced hepatotoxicity at the transcriptome level. Toxicological Sciences : An Official Journal of the Society of Toxicology. 79: 411-22. PMID 15056800 DOI: 10.1093/Toxsci/Kfh128 |
0.413 |
|
| 2004 |
Chen C, Klaassen CD. Rat multidrug resistance protein 4 (Mrp4, Abcc4): molecular cloning, organ distribution, postnatal renal expression, and chemical inducibility. Biochemical and Biophysical Research Communications. 317: 46-53. PMID 15047146 DOI: 10.1016/J.Bbrc.2004.03.014 |
0.459 |
|
| 2004 |
Xie Y, Liu J, Liu Y, Klaassen CD, Waalkes MP. Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b(-/-) double knockout mice. Molecular and Cellular Biochemistry. 255: 11-8. PMID 14971641 DOI: 10.1023/B:Mcbi.0000007256.44450.8C |
0.465 |
|
| 2004 |
Li N, Choudhuri S, Cherrington NJ, Klaassen CD. DOWN-REGULATION OF MOUSE ORGANIC ANION-TRANSPORTING POLYPEPTIDE 4 (Oatp4; Oatp1b2; Slc21a10) mRNA BY LIPOPOLYSACCHARIDE THROUGH THE TOLL-LIKE RECEPTOR 4 (TLR4) Drug Metabolism and Disposition. 32: 1265-1271. DOI: 10.1124/Dmd.32.11.1265 |
0.367 |
|
| 2003 |
Choudhuri S, Cherrington NJ, Li N, Klaassen CD. Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1337-45. PMID 14570765 DOI: 10.1124/Dmd.31.11.1337 |
0.407 |
|
| 2003 |
Cherrington NJ, Slitt AL, Maher JM, Zhang XX, Zhang J, Huang W, Wan YJ, Moore DD, Klaassen CD. Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1315-9. PMID 14570762 DOI: 10.1124/Dmd.31.11.1315 |
0.757 |
|
| 2003 |
Slitt AL, Cherrington NJ, Maher JM, Klaassen CD. Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1176-86. PMID 12920174 DOI: 10.1124/Dmd.31.9.1176 |
0.736 |
|
| 2003 |
Chen C, Staudinger JL, Klaassen CD. Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 908-15. PMID 12814968 DOI: 10.1124/Dmd.31.7.908 |
0.515 |
|
| 2003 |
Buist SC, Cherrington NJ, Klaassen CD. Endocrine regulation of rat organic anion transporters. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 559-64. PMID 12695343 DOI: 10.1124/Dmd.31.5.559 |
0.812 |
|
| 2003 |
Hood A, Allen ML, Liu Y, Liu J, Klaassen CD. Induction of T4 UDP-GT activity, serum thyroid stimulating hormone, and thyroid follicular cell proliferation in mice treated with microsomal enzyme inducers Toxicology and Applied Pharmacology. 188: 6-13. PMID 12668117 DOI: 10.1016/S0041-008X(02)00071-6 |
0.398 |
|
| 2003 |
Shelby MK, Cherrington NJ, Vansell NR, Klaassen CD. Tissue mRNA expression of the rat UDP-glucuronosyltransferase gene family. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 326-33. PMID 12584160 DOI: 10.1124/Dmd.31.3.326 |
0.8 |
|
| 2003 |
Leazer TM, Klaassen CD. The presence of xenobiotic transporters in rat placenta. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 153-67. PMID 12527696 DOI: 10.1124/Dmd.31.2.153 |
0.385 |
|
| 2003 |
Choudhuri S, Ogura K, Klaassen CD. Determination of transcription start site and analysis of promoter sequence, splice junction sites, intron sequence and codon usage bias of rat liver-specific organic anion transporter-1 (rlst-1/Oatp-4/Slc21a10) gene. Dna Sequence : the Journal of Dna Sequencing and Mapping. 13: 103-7. PMID 12180343 DOI: 10.1080/10425170290030015 |
0.34 |
|
| 2002 |
Leazer TM, Liu Y, Klaassen CD. Cadmium absorption and its relationship to divalent metal transporter-1 in the pregnant rat. Toxicology and Applied Pharmacology. 185: 18-24. PMID 12460733 DOI: 10.1006/Taap.2002.9505 |
0.353 |
|
| 2002 |
Johnson DR, Guo GL, Klaassen CD. Expression of rat Multidrug Resistance Protein 2 (Mrp2) in male and female rats during normal and pregnenolone-16alpha-carbonitrile (PCN)-induced postnatal ontogeny. Toxicology. 178: 209-19. PMID 12167307 DOI: 10.1016/S0300-483X(02)00231-7 |
0.372 |
|
| 2002 |
Park JD, Cherrington NJ, Klaassen CD. Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 68: 288-94. PMID 12151624 DOI: 10.1093/Toxsci/68.2.288 |
0.331 |
|
| 2002 |
Brady JM, Cherrington NJ, Hartley DP, Buist SC, Li N, Klaassen CD. Tissue distribution and chemical induction of multiple drug resistance genes in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 838-44. PMID 12065443 DOI: 10.1124/Dmd.30.7.838 |
0.828 |
|
| 2002 |
Harstad EB, Klaassen CD. iNOS-null mice are not resistant to cadmium chloride-induced hepatotoxicity. Toxicology. 175: 83-90. PMID 12049838 DOI: 10.1016/S0300-483X(02)00068-9 |
0.385 |
|
| 2002 |
Harstad EB, Klaassen CD. Analysis of strain difference in sensitivity to cadmium-induced hepatotoxicity in Fischer 344 and Sprague-Dawley rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 67: 329-40. PMID 12011493 DOI: 10.1093/Toxsci/67.2.329 |
0.328 |
|
| 2002 |
Johnson DR, Klaassen CD. Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways. Toxicological Sciences : An Official Journal of the Society of Toxicology. 67: 182-9. PMID 12011477 DOI: 10.1093/Toxsci/67.2.182 |
0.409 |
|
| 2002 |
Harstad EB, Klaassen CD. Gadolinium chloride pretreatment prevents cadmium chloride-induced liver damage in both wild-type and MT-null mice. Toxicology and Applied Pharmacology. 180: 178-85. PMID 12009857 DOI: 10.1006/Taap.2002.9385 |
0.39 |
|
| 2002 |
Li N, Hartley DP, Cherrington NJ, Klaassen CD. Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4. The Journal of Pharmacology and Experimental Therapeutics. 301: 551-60. PMID 11961056 DOI: 10.1124/Jpet.301.2.551 |
0.505 |
|
| 2002 |
Liu J, Kadiiska MB, Corton JC, Qu W, Waalkes MP, Mason RP, Liu Y, Klaassen CD. Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice. Free Radical Biology & Medicine. 32: 525-35. PMID 11958953 DOI: 10.1016/S0891-5849(01)00826-7 |
0.453 |
|
| 2002 |
Klaassen CD. Xenobiotic transporters: another protective mechanism for chemicals. International Journal of Toxicology. 21: 7-12. PMID 11936902 DOI: 10.1080/10915810252825975 |
0.345 |
|
| 2002 |
Johnson DR, Klaassen CD. Role of rat multidrug resistance protein 2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction. Toxicology and Applied Pharmacology. 180: 56-63. PMID 11922777 DOI: 10.1006/Taap.2002.9375 |
0.368 |
|
| 2002 |
Buist SC, Cherrington NJ, Choudhuri S, Hartley DP, Klaassen CD. Gender-specific and developmental influences on the expression of rat organic anion transporters. The Journal of Pharmacology and Experimental Therapeutics. 301: 145-51. PMID 11907168 DOI: 10.1124/Jpet.301.1.145 |
0.822 |
|
| 2002 |
Harstad EB, Klaassen CD. Tumor necrosis factor-alpha-null mice are not resistant to cadmium chloride-induced hepatotoxicity. Toxicology and Applied Pharmacology. 179: 155-62. PMID 11906245 DOI: 10.1006/Taap.2001.9362 |
0.408 |
|
| 2002 |
Guo GL, Staudinger J, Ogura K, Klaassen CD. Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor. Molecular Pharmacology. 61: 832-9. PMID 11901222 DOI: 10.1124/Mol.61.4.832 |
0.37 |
|
| 2002 |
Johnson DR, Habeebu SS, Klaassen CD. Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2. Toxicological Sciences : An Official Journal of the Society of Toxicology. 66: 16-26. PMID 11861969 DOI: 10.1093/Toxsci/66.1.16 |
0.407 |
|
| 2002 |
Guo GL, Johnson DR, Klaassen CD. Postnatal expression and induction by pregnenolone-16alpha-carbonitrile of the organic anion-transporting polypeptide 2 in rat liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 283-8. PMID 11854146 DOI: 10.1124/Dmd.30.3.283 |
0.427 |
|
| 2002 |
Vansell NR, Klaassen CD. Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 240-6. PMID 11854140 DOI: 10.1124/Dmd.30.3.240 |
0.823 |
|
| 2002 |
Park JD, Habeebu SS, Klaassen CD. Testicular toxicity of di-(2-ethylhexyl)phthalate in young Sprague-Dawley rats. Toxicology. 171: 105-15. PMID 11836017 DOI: 10.1016/S0300-483X(01)00567-4 |
0.349 |
|
| 2002 |
Vansell NR, Klaassen CD. Effect of microsomal enzyme inducers on the biliary excretion of triiodothyronine (T(3)) and its metabolites. Toxicological Sciences : An Official Journal of the Society of Toxicology. 65: 184-91. PMID 11812922 DOI: 10.1093/Toxsci/65.2.184 |
0.787 |
|
| 2002 |
Slitt AL, Cherrington NJ, Hartley DP, Leazer TM, Klaassen CD. Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 212-9. PMID 11792693 DOI: 10.1124/Dmd.30.2.212 |
0.373 |
|
| 2002 |
Guo GL, Choudhuri S, Klaassen CD. Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways. The Journal of Pharmacology and Experimental Therapeutics. 300: 206-12. PMID 11752118 DOI: 10.1124/Jpet.300.1.206 |
0.435 |
|
| 2002 |
Cherrington NJ, Hartley DP, Li N, Johnson DR, Klaassen CD. Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. The Journal of Pharmacology and Experimental Therapeutics. 300: 97-104. PMID 11752103 DOI: 10.1124/Jpet.300.1.97 |
0.5 |
|
| 2002 |
Liu J, Liu Y, Powell DA, Waalkes MP, Klaassen CD. Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues. Toxicology. 170: 55-62. PMID 11750083 DOI: 10.1016/S0300-483X(01)00532-7 |
0.433 |
|
| 2001 |
Vansell NR, Klaassen CD. Increased biliary excretion of thyroxine by microsomal enzyme inducers. Toxicology and Applied Pharmacology. 176: 187-94. PMID 11714251 DOI: 10.1006/Taap.2001.9278 |
0.789 |
|
| 2001 |
Liu J, Corton C, Dix DJ, Liu Y, Waalkes MP, Klaassen CD. Genetic background but not metallothionein phenotype dictates sensitivity to cadmium-induced testicular injury in mice. Toxicology and Applied Pharmacology. 176: 1-9. PMID 11578143 DOI: 10.1006/Taap.2001.9262 |
0.357 |
|
| 2001 |
Liu Y, Liu J, Klaassen CD. Metallothionein-null and wild-type mice show similar cadmium absorption and tissue distribution following oral cadmium administration. Toxicology and Applied Pharmacology. 175: 253-9. PMID 11559024 DOI: 10.1006/Taap.2001.9244 |
0.355 |
|
| 2001 |
Takiguchi M, Cherrington NJ, Hartley DP, Klaassen CD, Waalkes MP. Cyproterone acetate induces a cellular tolerance to cadmium in rat liver epithelial cells involving reduced cadmium accumulation. Toxicology. 165: 13-25. PMID 11551428 DOI: 10.1016/S0300-483X(01)00402-4 |
0.344 |
|
| 2001 |
Park JD, Liu Y, Klaassen CD. Protective effect of metallothionein against the toxicity of cadmium and other metals(1). Toxicology. 163: 93-100. PMID 11516518 DOI: 10.1016/S0300-483X(01)00375-4 |
0.372 |
|
| 2001 |
Liu J, Chen H, Miller DS, Saavedra JE, Keefer LK, Johnson DR, Klaassen CD, Waalkes MP. Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic. Molecular Pharmacology. 60: 302-9. PMID 11455017 DOI: 10.1124/Mol.60.2.302 |
0.369 |
|
| 2001 |
Rausch-Derra LC, Hartley DP, Meier PJ, Klaassen CD. Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2. Hepatology (Baltimore, Md.). 33: 1469-78. PMID 11391536 DOI: 10.1053/Jhep.2001.25088 |
0.481 |
|
| 2001 |
Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proceedings of the National Academy of Sciences of the United States of America. 98: 3369-74. PMID 11248085 DOI: 10.1073/Pnas.051551698 |
0.47 |
|
| 2001 |
Klaassen CD, Hood AM. Effects of microsomal enzyme inducers on thyroid follicular cell proliferation and thyroid hormone metabolism. Toxicologic Pathology. 29: 34-40. PMID 11215682 DOI: 10.1080/019262301301418838 |
0.329 |
|
| 2001 |
Ogura K, Choudhuri S, Klaassen CD. Genomic organization and tissue-specific expression of splice variants of mouse organic anion transporting polypeptide 2. Biochemical and Biophysical Research Communications. 281: 431-9. PMID 11181066 DOI: 10.1006/Bbrc.2001.4387 |
0.339 |
|
| 2001 |
Choudhuri S, Ogura K, Klaassen CD. Cloning, expression, and ontogeny of mouse organic anion-transporting polypeptide-5, a kidney-specific organic anion transporter. Biochemical and Biophysical Research Communications. 280: 92-8. PMID 11162483 DOI: 10.1006/Bbrc.2000.4072 |
0.403 |
|
| 2000 |
Liu Y, Liu J, Habeebu SM, Waalkes MP, Klaassen CD. Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 57: 167-76. PMID 10966523 DOI: 10.1093/Toxsci/57.1.167 |
0.357 |
|
| 2000 |
Jeong SH, Habeebu SS, Klaassen CD. Cadmium decreases gap junctional intercellular communication in mouse liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. 57: 156-66. PMID 10966522 DOI: 10.1093/Toxsci/57.1.156 |
0.382 |
|
| 2000 |
Liu J, Sendelbach LE, Parkinson A, Klaassen CD. Endotoxin pretreatment protects against the hepatotoxicity of acetaminophen and carbon tetrachloride: role of cytochrome P450 suppression. Toxicology. 147: 167-76. PMID 10924799 DOI: 10.1016/S0300-483X(00)00193-1 |
0.347 |
|
| 2000 |
Liu J, Liu Y, Habeebu SM, Waalkes MP, Klaassen CD. Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I/II null mice. Toxicology. 147: 157-66. PMID 10924798 DOI: 10.1016/S0300-483X(00)00194-3 |
0.325 |
|
| 2000 |
Choudhuri S, Ogura K, Klaassen CD. Cloning of the full-length coding sequence of rat liver-specific organic anion transporter-1 (rlst-1) and a splice variant and partial characterization of the rat lst-1 gene. Biochemical and Biophysical Research Communications. 274: 79-86. PMID 10903899 DOI: 10.1006/Bbrc.2000.3105 |
0.35 |
|
| 2000 |
Habeebu SS, Liu J, Liu Y, Klaassen CD. Metallothionein-null mice are more susceptible than wild-type mice to chronic CdCl(2)-induced bone injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 56: 211-9. PMID 10869470 DOI: 10.1093/Toxsci/56.1.211 |
0.301 |
|
| 2000 |
Ogura K, Choudhuri S, Klaassen CD. Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1). Biochemical and Biophysical Research Communications. 272: 563-70. PMID 10833452 DOI: 10.1006/Bbrc.2000.2830 |
0.425 |
|
| 2000 |
Dunn RT, Klaassen CD. Thyroid hormone modulation of rat sulphotransferase mRNA expression. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 30: 345-57. PMID 10821164 DOI: 10.1080/004982500237550 |
0.39 |
|
| 2000 |
Habeebu SS, Liu J, Liu Y, Klaassen CD. Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium. Toxicological Sciences : An Official Journal of the Society of Toxicology. 55: 223-32. PMID 10788577 DOI: 10.1093/Toxsci/55.1.223 |
0.465 |
|
| 2000 |
Hood A, Klaassen CD. Differential effects of microsomal enzyme inducers on in vitro thyroxine (T(4)) and triiodothyronine (T(3)) glucuronidation. Toxicological Sciences : An Official Journal of the Society of Toxicology. 55: 78-84. PMID 10788562 DOI: 10.1093/Toxsci/55.1.78 |
0.331 |
|
| 2000 |
Kolaja KL, Engelken DT, Klaassen CD. Inhibition of gap-junctional-intercellular communication in intact rat liver by nongenotoxic hepatocarcinogens. Toxicology. 146: 15-22. PMID 10773359 DOI: 10.1016/S0300-483X(00)00162-1 |
0.389 |
|
| 2000 |
Hood A, Klaassen CD. Effects of microsomal enzyme inducers on outer-ring deiodinase activity toward thyroid hormones in various rat tissues. Toxicology and Applied Pharmacology. 163: 240-8. PMID 10702363 DOI: 10.1006/Taap.1999.8883 |
0.361 |
|
| 2000 |
Klaassen CD, Choudhuri S. Use of genetically altered animal models in understanding the role of metallothionein in cadmium toxicity Pure and Applied Chemistry. 72: 1023-1026. DOI: 10.1351/Pac200072061023 |
0.397 |
|
| 1999 |
Rojas P, Klaassen CD. Metallothionein-I and -II knock-out mice are not more sensitive than control mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Neuroscience Letters. 273: 113-6. PMID 10505629 DOI: 10.1016/S0304-3940(99)00651-5 |
0.38 |
|
| 1999 |
Liu J, Liu Y, Habeebu SS, Klaassen CD. Metallothionein-null mice are highly susceptible to the hematotoxic and immunotoxic effects of chronic CdCl2 exposure. Toxicology and Applied Pharmacology. 159: 98-108. PMID 10495773 DOI: 10.1006/Taap.1999.8718 |
0.317 |
|
| 1999 |
Liu Y, Liu J, Habeebu SS, Klaassen CD. Metallothionein protects against the nephrotoxicity produced by chronic CdMT exposure. Toxicological Sciences : An Official Journal of the Society of Toxicology. 50: 221-7. PMID 10478858 DOI: 10.1093/Toxsci/50.2.221 |
0.377 |
|
| 1999 |
Hood A, Liu J, Klaassen CD. Effects of phenobarbital, pregnenolone-16alpha-carbonitrile, and propylthiouracil on thyroid follicular cell proliferation. Toxicological Sciences : An Official Journal of the Society of Toxicology. 50: 45-53. PMID 10445752 DOI: 10.1093/Toxsci/50.1.45 |
0.309 |
|
| 1999 |
Dunn RT, Kolaja KL, Klaassen CD. Effect of partial hepatectomy on the expression of seven rat sulphotransferase mRNAs. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 29: 583-93. PMID 10426557 DOI: 10.1080/004982599238407 |
0.412 |
|
| 1999 |
Gregus Z, Halászi E, Klaassen CD. Effect of chlorophenoxyacetic acid herbicides on glycine conjugation of benzoic acid. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 29: 547-59. PMID 10426554 DOI: 10.1080/004982599238371 |
0.319 |
|
| 1999 |
Klaassen CD, Liu J, Choudhuri S. Metallothionein: an intracellular protein to protect against cadmium toxicity. Annual Review of Pharmacology and Toxicology. 39: 267-94. PMID 10331085 DOI: 10.1146/Annurev.Pharmtox.39.1.267 |
0.343 |
|
| 1999 |
Liu J, Kimler BF, Liu Y, Klaassen CD. Metallothionein-I transgenic mice are not protected from gamma-radiation. Toxicology Letters. 104: 183-7. PMID 10079052 DOI: 10.1016/S0378-4274(98)00362-2 |
0.37 |
|
| 1999 |
Liu J, Liu Y, Habeebu SS, Klaassen CD. Susceptibility of MT-null mice to chronic CdCl2-induced nephrotoxicity indicates that renal injury is not mediated by the CdMT complex. Toxicological Sciences : An Official Journal of the Society of Toxicology. 46: 197-203. PMID 9928683 DOI: 10.1006/Toxs.1998.2541 |
0.334 |
|
| 1999 |
Kolaja KL, Klaassen CD. Dose-response examination of UDP-glucuronosyltransferase inducers and their ability to increase both TGF-beta expression and thyroid follicular cell apoptosis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 46: 31-7. PMID 9928666 DOI: 10.1006/Toxs.1998.2510 |
0.301 |
|
| 1999 |
Oguro T, Liu J, Klaassen CD, Yoshida T. Inhibitory effect of oleanolic acid on 12-O-tetradecanoylphorbol-13-acetate-induced gene expression in mouse skin. Toxicological Sciences : An Official Journal of the Society of Toxicology. 45: 88-93. PMID 9848115 DOI: 10.1006/Toxs.1998.2485 |
0.367 |
|
| 1999 |
Liu J, Liu Y, Hartley D, Klaassen CD, Shehin-Johnson SE, Lucas A, Cohen SD. Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity. Journal of Pharmacology and Experimental Therapeutics. 289: 580-586. DOI: 10.1007/978-3-0348-8847-9_81 |
0.461 |
|
| 1998 |
Klaassen CD, Liu J. Metallothionein transgenic and knock-out mouse models in the study of cadmium toxicity. The Journal of Toxicological Sciences. 97-102. PMID 9760441 DOI: 10.2131/Jts.23.Supplementii_97 |
0.358 |
|
| 1998 |
Boles JW, Klaassen CD. Effects of molybdate on the sulfation of harmol and alpha-naphthol. Toxicology. 127: 121-7. PMID 9699799 DOI: 10.1016/S0300-483X(98)00029-8 |
0.302 |
|
| 1998 |
Klaassen CD, Liu L, Dunn RT. Regulation of sulfotransferase mRNA expression in male and female rats of various ages. Chemico-Biological Interactions. 109: 299-313. PMID 9566754 DOI: 10.1016/S0009-2797(97)00141-5 |
0.376 |
|
| 1998 |
Klaassen CD, Liu J. Induction of metallothionein as an adaptive mechanism affecting the magnitude and progression of toxicological injury. Environmental Health Perspectives. 297-300. PMID 9539022 DOI: 10.1289/Ehp.98106S1297 |
0.345 |
|
| 1998 |
Liu J, Liu Y, Habeebu SS, Klaassen CD. Metallothionein (MT)-null mice are sensitive to cisplatin-induced hepatotoxicity. Toxicology and Applied Pharmacology. 149: 24-31. PMID 9512723 DOI: 10.1006/Taap.1997.8325 |
0.449 |
|
| 1997 |
Klaassen CD, Boles JW. Sulfation and sulfotransferases 5: the importance of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) in the regulation of sulfation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 11: 404-18. PMID 9194521 DOI: 10.1096/Fasebj.11.6.9194521 |
0.356 |
|
| 1997 |
Thompson TN, Klaassen CD. The effects of hepatic microsomal enzyme inducers on the pharmacokinetics of ouabain after portal and systemic administration to rats. The Journal of Pharmacy and Pharmacology. 47: 1041-7. PMID 8932692 DOI: 10.1111/J.2042-7158.1995.Tb03294.X |
0.377 |
|
| 1996 |
Liu L, LeCluyse EL, Liu J, Klaassen CD. Sulfotransferase gene expression in primary cultures of rat hepatocytes. Biochemical Pharmacology. 52: 1621-30. PMID 8937478 DOI: 10.1016/S0006-2952(96)00569-2 |
0.357 |
|
| 1996 |
Zheng H, Liu J, Liu Y, Klaassen CD. Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium- and tert-butylhydroperoxide-induced cytotoxicity. Toxicology Letters. 87: 139-45. PMID 8914622 DOI: 10.1016/0378-4274(96)03770-8 |
0.339 |
|
| 1996 |
Madhu C, Gregus Z, Klaassen CD. Simple method for analysis of diquat in biological fluids and tissues by high-performance liquid chromatography. Journal of Chromatography. B, Biomedical Applications. 674: 193-6. PMID 8788148 DOI: 10.1016/0378-4347(95)00306-1 |
0.334 |
|
| 1996 |
Liu L, Klaassen CD. Different mechanism of saturation of acetaminophen sulfate conjugation in mice and rats. Toxicology and Applied Pharmacology. 139: 128-34. PMID 8685895 DOI: 10.1006/Taap.1996.0151 |
0.428 |
|
| 1996 |
Liu YP, Liu J, Palmiter RD, Klaassen CD. Metallothionein-I-transgenic mice are not protected from acute cadmium-metallothionein-induced nephrotoxicity. Toxicology and Applied Pharmacology. 137: 307-15. PMID 8661357 DOI: 10.1006/Taap.1996.0085 |
0.41 |
|
| 1996 |
Oguro T, Madhu C, Liu J, Klaassen CD. Molybdate impairs glycosaminoglycan sulfation in rat cartilage. Toxicology and Applied Pharmacology. 136: 354-60. PMID 8619244 DOI: 10.1006/Taap.1996.0043 |
0.327 |
|
| 1996 |
Liu J, Liu Y, Michalska AE, Choo KH, Klaassen CD. Distribution and retention of cadmium in metallothionein I and II null mice. Toxicology and Applied Pharmacology. 136: 260-8. PMID 8619234 DOI: 10.1006/Taap.1996.0033 |
0.377 |
|
| 1996 |
Zheng H, Liu J, Choo KH, Michalska AE, Klaassen CD. Metallothionein-I and -II knock-out mice are sensitive to cadmium-induced liver mRNA expression of c-jun and p53. Toxicology and Applied Pharmacology. 136: 229-35. PMID 8619230 DOI: 10.1006/Taap.1996.0029 |
0.443 |
|
| 1996 |
Choudhuri S, Liu WL, Berman NE, Klaassen CD. Cadmium accumulation and metallothionein expression in brain of mice at different stages of development. Toxicology Letters. 84: 127-33. PMID 8600611 DOI: 10.1016/0378-4274(95)03444-7 |
0.389 |
|
| 1996 |
Iszard MB, Liu J, Klaassen CD. Effect of several metallothionein inducers on oxidative stress defense mechanisms in rats. Toxicology. 104: 25-33. PMID 8560499 DOI: 10.1016/0300-483X(95)03118-Y |
0.318 |
|
| 1996 |
Kramer KK, Liu J, Choudhuri S, Klaassen CD. Induction of metallothionein mRNA and protein in murine astrocyte cultures. Toxicology and Applied Pharmacology. 136: 94-100. PMID 8560486 DOI: 10.1006/Taap.1996.0011 |
0.337 |
|
| 1996 |
LIU J, KLAASSEN CD. Absorption and Distribution of Cadmium in Metallothionein-I Transgenic Mice Toxicological Sciences. 29: 294-300. DOI: 10.1093/Toxsci/29.2.294 |
0.373 |
|
| 1996 |
Kramer KK, Zoelle JT, Klaassen CD. Induction of metallothionein mRNA and proteinin primary murine neuron cultures Toxicology and Applied Pharmacology. 141: 1-7. DOI: 10.1016/S0041-008X(96)80002-0 |
0.313 |
|
| 1995 |
Liu Y, Liu J, Iszard MB, Andrews GK, Palmiter RD, Klaassen CD. Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity. Toxicology and Applied Pharmacology. 135: 222-8. PMID 8545831 DOI: 10.1006/Taap.1995.1227 |
0.409 |
|
| 1995 |
Choudhuri S, Kramer KK, Berman NE, Dalton TP, Andrews GK, Klaassen CD. Constitutive expression of metallothionein genes in mouse brain. Toxicology and Applied Pharmacology. 131: 144-54. PMID 7878670 DOI: 10.1006/Taap.1995.1056 |
0.36 |
|
| 1995 |
Liu J, Liu Y, Bullock P, Klaassen CD. Suppression of liver cytochrome P450 by alpha-hederin: relevance to hepatoprotection. Toxicology and Applied Pharmacology. 134: 124-31. PMID 7676446 DOI: 10.1006/Taap.1995.1175 |
0.36 |
|
| 1995 |
Zheng H, Berman NE, Klaassen CD. Chemical modulation of metallothionein I and III mRNA in mouse brain. Neurochemistry International. 27: 43-58. PMID 7655347 DOI: 10.1016/0197-0186(94)00167-S |
0.39 |
|
| 1995 |
Iszard MB, Liu J, Liu Y, Dalton T, Andrews GK, Palmiter RD, Klaassen CD. Characterization of metallothionein-I-transgenic mice. Toxicology and Applied Pharmacology. 133: 305-12. PMID 7645027 DOI: 10.1006/Taap.1995.1155 |
0.465 |
|
| 1994 |
Choudhuri S, McKim JM, Klaassen CD. Induction of metallothionein by superantigenic bacterial exotoxin: probable involvement of the immune system Bba - Molecular Basis of Disease. 1225: 171-179. PMID 8280785 DOI: 10.1016/0925-4439(94)90075-2 |
0.411 |
|
| 1994 |
Henry RB, Liu J, Choudhuri S, Klaassen CD. Species variation in hepatic metallothionein. Toxicology Letters. 74: 23-33. PMID 8085268 DOI: 10.1016/0378-4274(94)90071-X |
0.412 |
|
| 1994 |
Barter RA, Klaassen CD. Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronosyltransferase inducers in rats. Toxicology and Applied Pharmacology. 128: 9-17. PMID 8079359 DOI: 10.1006/Taap.1994.1174 |
0.312 |
|
| 1994 |
Gregus Z, Oguro T, Klaassen CD. Nutritionally and chemically induced impairment of sulfate activation and sulfation of xenobiotics in vivo. Chemico-Biological Interactions. 92: 169-77. PMID 8033252 DOI: 10.1016/0009-2797(94)90062-0 |
0.434 |
|
| 1994 |
Liu J, Liu Y, Klaassen CD. The effect of Chinese hepatoprotective medicines on experimental liver injury in mice. Journal of Ethnopharmacology. 42: 183-91. PMID 7934088 DOI: 10.1016/0378-8741(94)90084-1 |
0.419 |
|
| 1994 |
KREPPEL H, LIU J, LIU Y, REICHL FX, KLAASSEN CD. Zinc-Induced Arsenite Tolerance in Mice Toxicological Sciences. 23: 32-37. DOI: 10.1006/Faat.1994.1075 |
0.454 |
|
| 1994 |
LIU L, LIU Y, MAO Q, KLAASSEN C. The Effects of 10 Triterpenoid Compounds on Experimental Liver Injury in Mice Toxicological Sciences. 22: 34-40. DOI: 10.1006/Faat.1994.1005 |
0.381 |
|
| 1993 |
Gregus Z, Fekete T, Varga F, Klaassen CD. Dependence of glycine conjugation on availability of glycine: role of the glycine cleavage system. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 23: 141-53. PMID 8498078 DOI: 10.3109/00498259309059370 |
0.361 |
|
| 1993 |
Choudhuri S, McKim JM, Klaassen CD. Differential expression of the metallothionein gene in liver and brain of mice and rats Toxicology and Applied Pharmacology. 119: 1-10. PMID 8470112 DOI: 10.1006/Taap.1993.1037 |
0.41 |
|
| 1993 |
Liu J, Choudhuri S, Liu Y, Kreppel H, Andrews GK, Klaassen CD. Induction of metallothionein by alpha-hederin. Toxicology and Applied Pharmacology. 121: 144-51. PMID 8337695 DOI: 10.1006/Taap.1993.1139 |
0.346 |
|
| 1993 |
Bauman JW, Liu YP, Andrews GK, Klaassen CD. Examination of potential mechanism(s) of metallothionein induction by diethyl maleate. Toxicology and Applied Pharmacology. 117: 226-32. PMID 1471155 DOI: 10.1016/0041-008X(92)90241-J |
0.456 |
|
| 1993 |
Kreppel H, Bauman JW, Liu J, Mckim JM, Klaassen CD. Induction of metallothionein by arsenicals in mice Toxicological Sciences. 20: 184-189. DOI: 10.1006/Faat.1993.1025 |
0.4 |
|
| 1992 |
Klaassen CD. Biliary excretion of manganese in rats, rabbits, and dogs. Toxicology and Applied Pharmacology. 29: 458-68. PMID 4283708 DOI: 10.1016/0041-008X(74)90117-3 |
0.38 |
|
| 1992 |
Klaassen CD. Biliary excretion of arsenic in rats, rabbits, and dogs. Toxicology and Applied Pharmacology. 29: 447-57. PMID 4283707 DOI: 10.1016/0041-008X(74)90116-1 |
0.372 |
|
| 1992 |
Klaassen CD, Shoeman DW. Biliary excretion of lead in rats, rabbits, and dogs. Toxicology and Applied Pharmacology. 29: 434-46. PMID 4283706 DOI: 10.1016/0041-008X(74)90115-X |
0.414 |
|
| 1992 |
Kershaw WC, Klaassen CD. Degradation and metal composition of hepatic isometallothioneins in rats. Toxicology and Applied Pharmacology. 112: 24-31. PMID 1733046 DOI: 10.1016/0041-008X(92)90275-W |
0.305 |
|
| 1992 |
Barter RA, Klaassen CD. Rat liver microsomal UDP-glucuronosyltransferase activity toward thyroxine: characterization, induction, and form specificity. Toxicology and Applied Pharmacology. 115: 261-7. PMID 1641859 DOI: 10.1016/0041-008X(92)90331-L |
0.359 |
|
| 1992 |
Madhu C, Maziasz T, Klaassen CD. Effect of pregnenolone-16 alpha-carbonitrile and dexamethasone on acetaminophen-induced hepatotoxicity in mice. Toxicology and Applied Pharmacology. 115: 191-8. PMID 1641853 DOI: 10.1016/0041-008X(92)90323-K |
0.497 |
|
| 1992 |
Choudhuri S, McKim JM, Klaassen CD. Role of hepatic lysosomes in the degradation of metallothionein Toxicology and Applied Pharmacology. 115: 64-71. PMID 1631896 DOI: 10.1016/0041-008X(92)90368-3 |
0.308 |
|
| 1992 |
Bauman JW, McKim JM, Liu J, Klaassen CD. Induction of metallothionein by diethyl maleate Toxicology and Applied Pharmacology. 114: 188-196. PMID 1609410 DOI: 10.1016/0041-008X(92)90068-4 |
0.387 |
|
| 1992 |
Gregus Z, Stein AF, Varga F, Klaassen CD. Effect of lipoic acid on biliary excretion of glutathione and metals. Toxicology and Applied Pharmacology. 114: 88-96. PMID 1585376 DOI: 10.1016/0041-008X(92)90100-7 |
0.375 |
|
| 1992 |
Madhu C, Klaassen CD. Bromobenzene-glutathione excretion into bile reflects toxic activation of bromobenzene in rats. Toxicology Letters. 60: 227-36. PMID 1570637 DOI: 10.1016/0378-4274(92)90278-R |
0.416 |
|
| 1992 |
Barter RA, Klaassen CD. UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism. Toxicology and Applied Pharmacology. 113: 36-42. PMID 1553754 DOI: 10.1016/0041-008X(92)90006-E |
0.319 |
|
| 1992 |
Sendelbach LE, Kershaw WC, Cuppage F, Klaassen CD. Cd-metallothionein nephrotoxicity in inbred strains of mice. Journal of Toxicology and Environmental Health. 35: 115-26. PMID 1542133 DOI: 10.1080/15287399209531600 |
0.345 |
|
| 1992 |
McKim JM, Liu J, Liu YP, Klaassen CD. Distribution of cadmium chloride and cadmium-metallothionein to liver parenchymal, Kupffer, and endothelial cells: Their relative ability to express metallothionein Toxicology and Applied Pharmacology. 112: 324-330. PMID 1539169 DOI: 10.1016/0041-008X(92)90203-5 |
0.34 |
|
| 1992 |
McKim JM, Liu J, Liu YP, Klaassen CD. Induction of metallothionein by cadmium-metallothionein in rat liver: A proposed mechanism Toxicology and Applied Pharmacology. 112: 318-323. PMID 1539168 DOI: 10.1016/0041-008X(92)90202-4 |
0.366 |
|
| 1992 |
Dorian C, Gattone VH, Klaassen CD. Accumulation and degradation of the protein moiety of cadmium-metallothionein (CdMT) in the mouse kidney. Toxicology and Applied Pharmacology. 117: 242-8. PMID 1471157 DOI: 10.1016/0041-008X(92)90243-L |
0.302 |
|
| 1992 |
Bauman JW, Madhu C, McKim JM, Liu Y, Klaassen CD. Induction of hepatic metallothionein by paraquat Toxicology and Applied Pharmacology. 117: 233-241. PMID 1471156 DOI: 10.1016/0041-008X(92)90242-K |
0.421 |
|
| 1992 |
Liu J, Kershaw WC, Liu YP, Klaassen CD. Cadmium-induced hepatic endothelial cell injury in inbred strains of mice. Toxicology. 75: 51-62. PMID 1455424 DOI: 10.1016/0300-483X(92)90125-X |
0.345 |
|
| 1992 |
Goon D, Klaassen CD. Effects of microsomal enzyme inducers upon UDP-glucuronic acid concentration and UDP-glucuronosyltransferase activity in the rat intestine and liver. Toxicology and Applied Pharmacology. 115: 253-60. PMID 1386480 DOI: 10.1016/0041-008X(92)90330-U |
0.433 |
|
| 1991 |
Kershaw WC, Iga T, Klaassen CD. Ethanol decreases cadmium hepatotoxicity in rats: possible role of hepatic metallothionein induction. Toxicology and Applied Pharmacology. 106: 448-55. PMID 2260092 DOI: 10.1016/0041-008X(90)90339-V |
0.303 |
|
| 1991 |
Kershaw WC, Klaassen CD. Cadmium-induced elevation of hepatic isometallothionein concentrations in inbred strains of mice. Chemico-Biological Interactions. 78: 269-82. PMID 2070432 DOI: 10.1016/0009-2797(91)90058-F |
0.334 |
|
| 1991 |
Madhu C, Klaassen CD. Protective effect of pregnenolone-16 alpha-carbonitrile on acetaminophen-induced hepatotoxicity in hamsters. Toxicology and Applied Pharmacology. 109: 305-13. PMID 2068728 DOI: 10.1016/0041-008X(91)90177-G |
0.433 |
|
| 1991 |
Liu J, Liu YP, Sendelbach LE, Klaassen CD. Endotoxin induction of hepatic metallothionein is mediated through cytokines. Toxicology and Applied Pharmacology. 109: 235-240. PMID 2068724 DOI: 10.1016/0041-008X(91)90171-A |
0.351 |
|
| 1991 |
Howell SR, Klaassen C. Circadian variation of hepatic UDP-glucuronic acid and the glucuronidation of xenobiotics in mice. Toxicology Letters. 57: 73-79. PMID 2048163 DOI: 10.1016/0378-4274(91)90121-L |
0.408 |
|
| 1991 |
Maziasz TJ, Liu J, Madhu C, Klaassen CD. The differential effects of hepatotoxicants on the sulfation pathway in rats. Toxicology and Applied Pharmacology. 110: 365-73. PMID 1949007 DOI: 10.1016/0041-008X(91)90039-H |
0.435 |
|
| 1991 |
Bauman JW, Liu J, Liu YP, Klaassen CD. Increase in metallothionein produced by chemicals that induce oxidative stress. Toxicology and Applied Pharmacology. 110: 347-54. PMID 1891778 DOI: 10.1016/S0041-008X(05)80017-1 |
0.354 |
|
| 1990 |
Klaassen CD, Lehman-McKeeman LD. Regulation of the isoforms of metallothionein. Biological Trace Element Research. 21: 119-29. PMID 2484577 DOI: 10.1007/Bf02917244 |
0.37 |
|
| 1990 |
Kershaw WC, Lehman-McKeeman LD, Klaassen CD. Hepatic isometallothioneins in mice: induction in adults and postnatal ontogeny. Toxicology and Applied Pharmacology. 104: 267-75. PMID 2363178 DOI: 10.1016/0041-008X(90)90301-A |
0.434 |
|
| 1990 |
Sendelbach LE, White CA, Howell S, Gregus Z, Klaassen CD. Effect of sulfhydryl-deficient diets on hepatic metallothionein, glutathione, and adenosine 3'-phosphate 5'-phosphosulfate (PAPS) levels in rats. Toxicology and Applied Pharmacology. 102: 259-67. PMID 2300970 DOI: 10.1016/0041-008X(90)90025-P |
0.384 |
|
| 1989 |
Gregus Z, Madhu C, Klaassen CD. Inducibility of glutathione S-transferases in hamsters. Cancer Letters. 44: 89-94. PMID 2920375 DOI: 10.1016/0304-3835(89)90002-5 |
0.434 |
|
| 1989 |
Sendelbach LE, Bracken WM, Klaassen CD. Comparisons of the toxicity of CdCl2 and Cd-metallothionein in isolated rat hepatocytes. Toxicology. 55: 83-91. PMID 2711408 DOI: 10.1016/0300-483X(89)90176-5 |
0.301 |
|
| 1988 |
Howell SR, Kotkoskie LA, Dills RL, Klaassen CD. 3-Hydroxylation of salicylamide in mice. Journal of Pharmaceutical Sciences. 77: 309-13. PMID 3379587 DOI: 10.1002/Jps.2600770405 |
0.339 |
|
| 1988 |
Lehman-McKeeman LD, Andrews GK, Klaassen CD. Induction of hepatic metallothioneins determined at isoprotein and messenger RNA levels in glucocorticoid-treated rats. The Biochemical Journal. 249: 429-33. PMID 3342021 DOI: 10.1042/Bj2490429 |
0.334 |
|
| 1988 |
Sendelbach LE, Klaassen CD. Kidney synthesizes less metallothionein than liver in response to cadmium chloride and cadmium-metallothionein. Toxicology and Applied Pharmacology. 92: 95-102. PMID 3341030 DOI: 10.1016/0041-008X(88)90231-1 |
0.372 |
|
| 1988 |
Lehman-McKeeman LD, Andrews GK, Klaassen CD. Ontogeny and induction of hepatic isometallothioneins in immature rats. Toxicology and Applied Pharmacology. 92: 10-7. PMID 3341019 DOI: 10.1016/0041-008X(88)90222-0 |
0.392 |
|
| 1988 |
Lehman-McKeeman LD, Andrews GK, Klaassen CD. Mechanisms of regulation of rat hepatic metallothionein-I and metallothionein-II levels following administration of zinc. Toxicology and Applied Pharmacology. 92: 1-9. PMID 3341018 DOI: 10.1016/0041-008X(88)90221-9 |
0.321 |
|
| 1988 |
Gregus Z, White C, Howell S, Klaassen CD. Effect of glutathione depletion on sulfate activation and sulfate ester formation in rats. Biochemical Pharmacology. 37: 4307-12. PMID 3196355 DOI: 10.1016/0006-2952(88)90611-9 |
0.415 |
|
| 1988 |
Klaassen CD. Intestinal and hepatobiliary disposition of drugs. Toxicologic Pathology. 16: 130-7. PMID 3055222 DOI: 10.1177/019262338801600205 |
0.41 |
|
| 1988 |
Gregus Z, Klaassen CD. Effect of butylated hydroxyanisole on hepatic glucuronidation and biliary excretion of drugs in mice. The Journal of Pharmacy and Pharmacology. 40: 237-42. PMID 2900301 DOI: 10.1111/J.2042-7158.1988.Tb05235.X |
0.458 |
|
| 1988 |
Stein AF, Gregus Z, Klaassen CD. Species variations in biliary excretion of glutathione-related thiols and methylmercury. Toxicology and Applied Pharmacology. 93: 351-9. PMID 2897139 DOI: 10.1016/0041-008X(88)90037-3 |
0.353 |
|
| 1987 |
Stein AF, Bracken WM, Klaassen CD. Utilization of methionine as a sulfhydryl source for metallothionein synthesis in rat primary hepatocyte cultures. Toxicology and Applied Pharmacology. 87: 276-83. PMID 3824386 DOI: 10.1016/0041-008X(87)90289-4 |
0.321 |
|
| 1987 |
Bracken WM, Klaassen CD. Induction of hepatic metallothionein by alcohols: evidence for an indirect mechanism. Toxicology and Applied Pharmacology. 87: 257-63. PMID 3824384 DOI: 10.1016/0041-008X(87)90287-0 |
0.372 |
|
| 1987 |
Bracken WM, Klaassen CD. Induction of metallothionein in rat primary hepatocyte cultures: evidence for direct and indirect induction. Journal of Toxicology and Environmental Health. 22: 163-74. PMID 3669099 DOI: 10.1080/15287398709531060 |
0.334 |
|
| 1987 |
Lehman-McKeeman LD, Klaassen CD. Induction of metallothionein-I and metallothionein-II in rats by cadmium and zinc. Toxicology and Applied Pharmacology. 88: 195-202. PMID 3564038 DOI: 10.1016/0041-008X(87)90005-6 |
0.347 |
|
| 1987 |
Brzeznicka EA, Lehman LD, Klaassen CD. Induction of hepatic metallothionein following administration of urethane. Toxicology and Applied Pharmacology. 87: 457-63. PMID 3564020 DOI: 10.1016/0041-008X(87)90251-1 |
0.39 |
|
| 1987 |
Arlotto MP, Sonderfan AJ, Klaassen CD, Parkinson A. Studies on the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase. Biochemical Pharmacology. 36: 3859-66. PMID 3120728 DOI: 10.1016/0006-2952(87)90450-3 |
0.331 |
|
| 1987 |
Gregus Z, Stein AF, Klaassen CD. Age-dependent biliary excretion of glutathione-related thiols in rats: role of gamma-glutamyltransferase. The American Journal of Physiology. 253: G86-92. PMID 2886057 DOI: 10.1152/Ajpgi.1987.253.1.G86 |
0.384 |
|
| 1987 |
Bracken WM, Klaassen CD. Induction of metallothionein by steroids in rat primary hepatocyte cultures. Toxicology and Applied Pharmacology. 87: 381-8. PMID 2882620 DOI: 10.1016/0041-008X(87)90242-0 |
0.309 |
|
| 1986 |
Thompson TN, Klaassen CD. Hepatic presystemic elimination of diethylstilbestrol by rats and effect of pretreatment with inducers of UDP-glucuronosyltransferase. Journal of Toxicology and Environmental Health. 16: 615-29. PMID 3936941 DOI: 10.1080/15287398509530768 |
0.375 |
|
| 1986 |
Stein AF, Dills RL, Klaassen CD. High-performance liquid chromatographic analysis of glutathione and its thiol and disulfide degradation products. Journal of Chromatography. 381: 259-70. PMID 3760084 DOI: 10.1016/S0378-4347(00)83592-6 |
0.317 |
|
| 1986 |
Gregus Z, Klaassen CD. Disposition of metals in rats: a comparative study of fecal, urinary, and biliary excretion and tissue distribution of eighteen metals. Toxicology and Applied Pharmacology. 85: 24-38. PMID 3726885 DOI: 10.1016/0041-008X(86)90384-4 |
0.314 |
|
| 1986 |
Lehman LD, Klaassen CD. Separation and quantitation of metallothioneins by high-performance liquid chromatography coupled with atomic absorption spectrophotometry. Analytical Biochemistry. 153: 305-14. PMID 3706713 DOI: 10.1016/0003-2697(86)90097-7 |
0.327 |
|
| 1986 |
Hazelton GA, Hjelle JJ, Klaassen CD. Effects of butylated hydroxyanisole on acetaminophen hepatotoxicity and glucuronidation in vivo. Toxicology and Applied Pharmacology. 83: 474-85. PMID 3085287 DOI: 10.1016/0041-008X(86)90230-9 |
0.466 |
|
| 1985 |
Goering PL, Klaassen CD. Tolerance to cadmium-induced toxicity depends on presynthesized metallothionein in liver. Journal of Toxicology and Environmental Health. 14: 803-12. PMID 6520888 DOI: 10.1080/15287398409530628 |
0.305 |
|
| 1985 |
Klaassen CD, Bracken WM, Dudley RE, Goering PL, Hazelton GA, Hjelle JJ. Role of sulfhydryls in the hepatotoxicity of organic and metallic compounds. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 5: 806-15. PMID 4065457 DOI: 10.1016/0272-0590(85)90164-2 |
0.302 |
|
| 1985 |
Dills RL, Klaassen CD. An isocratic reverse-phase high-performance liquid chromatographic assay for adenine nucleotides in rat liver. Journal of Pharmacological Methods. 14: 189-97. PMID 4058016 DOI: 10.1016/0160-5402(85)90032-4 |
0.371 |
|
| 1985 |
Waalkes MP, Garvey JS, Klaassen CD. Comparison of methods of metallothionein quantification: cadmium radioassay, mercury radioassay, and radioimmunoassay. Toxicology and Applied Pharmacology. 79: 524-7. PMID 4035693 DOI: 10.1016/0041-008X(85)90149-8 |
0.316 |
|
| 1985 |
Goering PL, Klaassen CD. Mechanism of manganese-induced tolerance to cadmium lethality and hepatotoxicity. Biochemical Pharmacology. 34: 1371-9. PMID 3994753 DOI: 10.1016/0006-2952(85)90673-2 |
0.3 |
|
| 1985 |
Gorski JR, Arlotto MP, Klaassen CD, Parkinson A. Age- and sex-dependent induction of liver microsomal benzo[a]pyrene hydroxylase activity in rats treated with pregnenolone-16 alpha-carbonitrile (PCN). Carcinogenesis. 6: 617-24. PMID 3986963 DOI: 10.1093/Carcin/6.4.617 |
0.373 |
|
| 1985 |
Dudley RE, Gammal LM, Klaassen CD. Cadmium-induced hepatic and renal injury in chronically exposed rats: Likely role of hepatic cadmium-metallothionein in nephrotoxicity Toxicology and Applied Pharmacology. 77: 414-426. PMID 3975909 DOI: 10.1016/0041-008X(85)90181-4 |
0.344 |
|
| 1985 |
Rozman K, Hazelton GA, Klaassen CD, Arlotto MP, Parkinson A. Effect of thyroid hormones on liver microsomal enzyme induction in rats exposed to 2,3,7,8,-tetrachlorodibenzo-p-dioxin. Toxicology. 37: 51-63. PMID 3933144 DOI: 10.1016/0300-483X(85)90112-X |
0.398 |
|
| 1985 |
Hazelton GA, Hjelle JJ, Klaassen CD. Effects of butylated hydroxyanisole on hepatic glucuronidation capacity in mice. Toxicology and Applied Pharmacology. 78: 280-90. PMID 3929427 DOI: 10.1016/0041-008X(85)90291-1 |
0.499 |
|
| 1985 |
Stelzer KJ, Klaassen CD. Effect of cobalt on biliary excretion of bilirubin and glutathione. Journal of Toxicology and Environmental Health. 15: 813-22. PMID 3840533 DOI: 10.1080/15287398509530707 |
0.375 |
|
| 1985 |
Goering PL, Tandon SK, Klaassen CD. Induction of hepatic metallothionein in mouse liver following administration of chelating agents. Toxicology and Applied Pharmacology. 80: 467-72. PMID 2994260 DOI: 10.1016/0041-008X(85)90391-6 |
0.449 |
|
| 1985 |
WAALKES MP, KLAASSEN CD. Concentration of Metallothionein in Major Organs of Rats after Administration of Various Metals Toxicological Sciences. 5: 473-477. DOI: 10.1016/0272-0590(85)90094-6 |
0.368 |
|
| 1984 |
Goering PL, Klaassen CD. Resistance to cadmium-induced hepatotoxicity in immature rats. Toxicology and Applied Pharmacology. 74: 321-9. PMID 6740682 DOI: 10.1016/0041-008X(84)90285-0 |
0.331 |
|
| 1984 |
Waalkes MP, Klaassen CD. Postnatal ontogeny of metallothionein in various organs of the rat. Toxicology and Applied Pharmacology. 74: 314-20. PMID 6740681 DOI: 10.1016/0041-008X(84)90284-9 |
0.344 |
|
| 1984 |
Goering PL, Klaassen CD. Tolerance to cadmium-induced hepatotoxicity following cadmium pretreatment. Toxicology and Applied Pharmacology. 74: 308-13. PMID 6740680 DOI: 10.1016/0041-008X(84)90283-7 |
0.313 |
|
| 1984 |
Maitani T, Waalkes MP, Klaassen CD. Distribution of cadmium after oral administration of cadmium-thionein to mice. Toxicology and Applied Pharmacology. 74: 237-43. PMID 6740673 DOI: 10.1016/0041-008X(84)90148-0 |
0.303 |
|
| 1984 |
Dudley RE, Klaassen CD. Changes in hepatic glutathione concentration modify cadmium-induced hepatotoxicity Toxicology and Applied Pharmacology. 72: 530-538. PMID 6710502 DOI: 10.1016/0041-008X(84)90130-3 |
0.394 |
|
| 1984 |
Siegers CP, Rozman K, Klaassen CD. Biliary excretion and enterohepatic circulation of paracetamol in the rat. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 13: 591-6. PMID 6673372 DOI: 10.3109/00498258309052218 |
0.302 |
|
| 1984 |
Dudley RE, Svoboda DJ, Klaassen CD. Time course of cadmium-induced ultrastructural changes in rat liver Toxicology and Applied Pharmacology. 76: 150-160. PMID 6484985 DOI: 10.1016/0041-008X(84)90038-3 |
0.384 |
|
| 1984 |
Watkins JB, Siegers CP, Klaassen CD. Effect of diethyl ether on the biliary excretion of acetaminophen. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 177: 168-75. PMID 6473352 DOI: 10.3181/00379727-177-41928 |
0.34 |
|
| 1984 |
Smith GS, Watkins JB, Thompson TN, Rozman K, Klaassen CD. Oxidative and conjugative metabolism of xenobiotics by livers of cattle, sheep, swine and rats Journal of Animal Science. 58: 386-395. PMID 6423601 DOI: 10.2527/Jas1984.582386X |
0.413 |
|
| 1984 |
Waalkes MP, Hjelle JJ, Klaassen CD. Transient induction of hepatic metallothionein following oral ethanol administration. Toxicology and Applied Pharmacology. 74: 230-6. PMID 6377583 DOI: 10.1016/0041-008X(84)90147-9 |
0.33 |
|
| 1983 |
Cantilena LR, Klaassen CD. The effect of repeated administration of several chelators on the distribution and excretion of cadmium. Toxicology and Applied Pharmacology. 66: 361-7. PMID 7167963 DOI: 10.1016/0041-008X(82)90302-7 |
0.352 |
|
| 1983 |
Cagen SZ, Klaassen CD. Evaluation of hepatic storage of sulfobromophthalein in rats and dogs. Toxicology. 25: 261-70. PMID 7157403 DOI: 10.1016/0300-483X(82)90104-4 |
0.422 |
|
| 1983 |
Thompson TN, Klaassen CD. Disposition of metals after portal and systemic administration to rats. Toxicology and Applied Pharmacology. 68: 442-50. PMID 6857678 DOI: 10.1016/0041-008X(83)90289-2 |
0.319 |
|
| 1983 |
Gregus Z, Watkins JB, Thompson TN, Harvey MJ, Rozman K, Klaassen CD. Hepatic phase I and phase II biotransformations in quail and trout: Comparison to other species commonly used in toxicity testing Toxicology and Applied Pharmacology. 67: 430-441. PMID 6845369 DOI: 10.1016/0041-008X(83)90327-7 |
0.346 |
|
| 1983 |
Cantilena LR, Stacey NH, Klaassen CD. Isolated rat hepatocytes as a model system for screening chelators for use in cadmium intoxication. Toxicology and Applied Pharmacology. 67: 257-63. PMID 6836580 DOI: 10.1016/0041-008X(83)90232-6 |
0.303 |
|
| 1983 |
Stacey NH, Wong KL, Klaassen CD. Protective effects of chromium on the toxicity of cadmium in vivo. Toxicology. 28: 147-53. PMID 6636197 DOI: 10.1016/0300-483X(83)90113-0 |
0.331 |
|
| 1983 |
Harvey MJ, Klaassen CD. Interaction of metals and carbon tetrachloride on lipid peroxidation and hepatotoxicity. Toxicology and Applied Pharmacology. 71: 316-22. PMID 6558984 DOI: 10.1016/0041-008X(83)90018-2 |
0.324 |
|
| 1982 |
Klaassen CD. Induction of metallothionein by adrenocortical steroids. Toxicology. 20: 275-9. PMID 7314118 DOI: 10.1016/0300-483X(81)90034-2 |
0.366 |
|
| 1982 |
Dudley RE, Svoboda DJ, Klaassen CD. Acute exposure to cadmium causes severe liver injury in rats Toxicology and Applied Pharmacology. 65: 302-313. PMID 7179286 DOI: 10.1016/0041-008X(82)90013-8 |
0.359 |
|
| 1982 |
Thompson TN, Watkins JB, Gregus Z, Klaassen CD. Effect of microsomal enzyme inducers on the soluble enzymes of hepatic phase II biotransformation Toxicology and Applied Pharmacology. 66: 400-408. PMID 7167967 DOI: 10.1016/0041-008X(82)90306-4 |
0.323 |
|
| 1982 |
Klaassen CD, Wong KL. Cadmium toxicity in the newborn rat. Canadian Journal of Physiology and Pharmacology. 60: 1027-36. PMID 7127206 DOI: 10.1139/Y82-147 |
0.406 |
|
| 1982 |
Thompson TN, Klaassen CD. Presystemic elimination of manganese in rats. Toxicology and Applied Pharmacology. 64: 236-43. PMID 7123552 DOI: 10.1016/0041-008X(82)90220-4 |
0.35 |
|
| 1982 |
Watkins JB, Klaassen CD. Determination of hepatic uridine 5′-diphosphoglucuronic acid concentration by conjugation with diethylstilbestrol Journal of Pharmacological Methods. 7: 145-151. PMID 7098497 DOI: 10.1016/0160-5402(82)90027-4 |
0.378 |
|
| 1982 |
Watkins JB, Gregus Z, Thompson TN, Klaassen CD. Induction studies on the functional heterogeneity of rat liver UDP-glucuronosyltransferases Toxicology and Applied Pharmacology. 64: 439-446. PMID 6814015 DOI: 10.1016/0041-008X(82)90240-X |
0.307 |
|
| 1982 |
Cantilena LR, Klaassen CD. The effect of chelating agents on the excretion of endogenous metals. Toxicology and Applied Pharmacology. 63: 344-50. PMID 6285552 DOI: 10.1016/0041-008X(82)90263-0 |
0.337 |
|
| 1982 |
Stacey NH, Klaassen CD. Effects of phospholipase A2 inhibitors on diethyl maleate-induced lipid peroxidation and cellular injury in isolated rat hepatocytes. Journal of Toxicology and Environmental Health. 9: 439-50. PMID 6284950 DOI: 10.1080/15287398209530176 |
0.301 |
|
| 1982 |
Cantilena LR, Klaassen CD. Decreased effectiveness of chelation therapy with time after acute cadmium poisoning. Toxicology and Applied Pharmacology. 63: 173-80. PMID 6283691 DOI: 10.1016/0041-008X(82)90038-2 |
0.324 |
|
| 1982 |
Gregus Z, Klaassen CD. Comparison of Biliary excretion of organic anions in mice and rats. Toxicology and Applied Pharmacology. 63: 13-20. PMID 6176049 DOI: 10.1016/0041-008X(82)90021-7 |
0.435 |
|
| 1981 |
Stacey NH, Klaassen CD. Copper toxicity in isolated rat hepatocytes. Toxicology and Applied Pharmacology. 58: 211-20. PMID 7245197 DOI: 10.1016/0041-008X(81)90425-7 |
0.308 |
|
| 1981 |
Wong KL, Klaassen CD. Relationship between liver and kidney levels of glutathione and metallothionein in rats. Toxicology. 19: 39-47. PMID 7222057 DOI: 10.1016/0300-483X(81)90063-9 |
0.43 |
|
| 1981 |
Wong KL, Cachia R, Klaassen CD. Comparison of the toxicity and tissue distribution of cadmium in newborn and adult rats after repeated administration. Toxicology and Applied Pharmacology. 56: 317-25. PMID 7222016 DOI: 10.1016/0041-008X(80)90064-2 |
0.321 |
|
| 1981 |
Watkins JB, Klaassen CD. Choleretic effect of valproic acid in the rat Hepatology. 1: 341-347. PMID 6793496 DOI: 10.1002/Hep.1840010411 |
0.375 |
|
| 1980 |
Cagen SZ, Klaassen CD. Binding of glutathione-depleting agents to metallothionein. Toxicology and Applied Pharmacology. 54: 229-37. PMID 7423489 DOI: 10.1016/0041-008X(80)90191-X |
0.353 |
|
| 1980 |
Wong KL, Klaassen CD. Tissue distribution and retention of cadmium in rats during postnatal development: minimal role of hepatic metallothionein. Toxicology and Applied Pharmacology. 53: 343-53. PMID 7394775 DOI: 10.1016/0041-008X(80)90435-4 |
0.365 |
|
| 1980 |
Cantilena LR, Klaassen CD. The effect of ethylenediaminetetraacetic acid (EDTA) and EDTA plus salicylate on acute cadmium toxicity and distribution. Toxicology and Applied Pharmacology. 53: 510-4. PMID 6770496 DOI: 10.1016/0041-008X(80)90363-4 |
0.335 |
|
| 1980 |
Kotsonis FN, Klaassen CD. Increase in hepatic metallothionein in rats treated with alkylating agents. Toxicology and Applied Pharmacology. 51: 19-27. PMID 524370 DOI: 10.1016/0041-008X(79)90004-8 |
0.346 |
|
| 1980 |
Cagen SZ, Klaassen CD. Protection of carbon tetrachloride-induced hepatotoxicity by zinc: role of metallothionein. Toxicology and Applied Pharmacology. 51: 107-16. PMID 524364 DOI: 10.1016/0041-008X(79)90013-9 |
0.409 |
|
| 1979 |
Klaassen CD. Biliary excretion of silver in the rat, rabbit, and dog. Toxicology and Applied Pharmacology. 50: 49-55. PMID 494300 DOI: 10.1016/0041-008X(79)90491-5 |
0.359 |
|
| 1979 |
Klaassen CD. Importance of hepatic function on the plasma disappearance and biliary excretion of hexachlorophene. Toxicology and Applied Pharmacology. 49: 113-7. PMID 473196 DOI: 10.1016/0041-008X(79)90283-7 |
0.319 |
|
| 1979 |
Iga T, Eaton DL, Klaassen CD. Uptake of unconjugated bilirubin by isolated rat hepatocytes. The American Journal of Physiology. 236: C9-14. PMID 434143 DOI: 10.1152/Ajpcell.1979.236.1.C9 |
0.348 |
|
| 1977 |
Klaassen CD. Effect of microsomal enzyme inducers on the biliary excretion of an exogenous load of bilirubin in newborn rats. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 153: 370-3. PMID 995969 DOI: 10.3181/00379727-153-39548 |
0.352 |
|
| 1976 |
Eaton DL, Klaassen CD. Effects of Acute Administration of Taurocholic and Taurochenodeoxycholic Acid on Biliary Lipid Excretion in the Rat Proceedings of the Society For Experimental Biology and Medicine. 151: 198-202. PMID 1250846 DOI: 10.3181/00379727-151-39173 |
0.314 |
|
| 1976 |
Klaassen CD. Pharmacokinetics of rose bengal in the rat, rabbit, dog and guinea pig. Toxicology and Applied Pharmacology. 38: 85-100. PMID 982474 DOI: 10.1016/0041-008X(76)90163-0 |
0.346 |
|
| 1976 |
Klaassen CD. Studies on the mechanism of spironolactone protection against indomethacin toxicity. Toxicology and Applied Pharmacology. 38: 127-35. PMID 982462 DOI: 10.1016/0041-008X(76)90166-6 |
0.303 |
|
| 1975 |
Klaassen CD. Effect of spironolactone on the distribution of mercury. Toxicology and Applied Pharmacology. 33: 366-75. PMID 1179439 DOI: 10.1016/0041-008X(75)90103-9 |
0.312 |
|
| 1975 |
Klaassen CD. Biliary excretion of mercury compounds. Toxicology and Applied Pharmacology. 33: 356-65. PMID 1179438 DOI: 10.1016/0041-008X(75)90102-7 |
0.343 |
|
| 1975 |
Klaassen CD. Hepatic uptake of cardiac glycosides in newborn rats, rabbits and dogs. Biochemical Pharmacology. 24: 923-5. PMID 1125093 DOI: 10.1016/0006-2952(75)90168-9 |
0.305 |
|
| 1973 |
Klaassen CD. Comparison of the toxicity of chemicals in newborn rats to bile duct-ligated and sham-operated rats and mice. Toxicology and Applied Pharmacology. 24: 37-44. PMID 4686785 DOI: 10.1016/0041-008X(73)90179-8 |
0.423 |
|
| 1973 |
Klaassen CD. The effect of altered hepatic function on the toxicity, plasma disappearance and biliary excretion of diethylstilbestrol. Toxicology and Applied Pharmacology. 24: 142-9. PMID 4686781 DOI: 10.1016/0041-008X(73)90189-0 |
0.356 |
|
| 1971 |
Klaassen CD. Plasma disappearance and biliary excretion of sulfobromophthalein and phenol-3,6-dibromphthalein disulfonate after microsomal enzyme induction. Biochemical Pharmacology. 19: 1241-9. PMID 4398009 DOI: 10.1016/0006-2952(70)90039-0 |
0.308 |
|
| 1969 |
Harbison RD, Klaassen CD, Becker BA. Hemodynamics of the isolated perfused liver of hypothyroid and hyperthyroid rats. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 132: 96-9. PMID 5344874 DOI: 10.3181/00379727-132-34157 |
0.373 |
|
| 1967 |
Klaassen CD, Plaa GL. Relative effects of various chlorinated hydrocarbons on liver and kidney function in mice. Toxicology and Applied Pharmacology. 9: 139-51. PMID 5967557 DOI: 10.1016/0041-008X(66)90038-X |
0.354 |
|
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