Rhian M. Touyz - Publications

Affiliations: 
Université de Montréal, Montréal, Canada 
Area:
Cell Biology, Animal Physiology Biology, Pathology

476 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Camargo LL, Trevelin SC, da Silva GHG, Dos Santos Dias AA, Oliveira MA, Mikhaylichenko O, Androwiki ACD, Dos Santos CX, Holbrook LM, Ceravolo GS, Denadai-Souza A, Ribeiro IMR, Sartoretto S, Laurindo FRM, Coltri PP, ... ... Touyz R, et al. Protein disulfide isomerase-mediated transcriptional upregulation of Nox1 contributes to vascular dysfunction in hypertension. Journal of Hypertension. 42: 984-999. PMID 38690903 DOI: 10.1097/HJH.0000000000003677  0.364
2023 Neves KB, Alves-Lopes R, Montezano AC, Touyz RM. Role of PARP and TRPM2 in VEGF Inhibitor-Induced Vascular Dysfunction. Journal of the American Heart Association. e027769. PMID 36802924 DOI: 10.1161/JAHA.122.027769  0.336
2021 Camargo LL, Montezano AC, Hussain M, Wang Y, Zou Z, Rios FJ, Neves KB, Alves-Lopes R, Awan FR, Guzik TJ, Jensen T, Hartley RC, Touyz RM. Central role of c-Src in NOX5- mediated redox signaling in vascular smooth muscle cells in human hypertension. Cardiovascular Research. PMID 34320175 DOI: 10.1093/cvr/cvab171  0.31
2021 Kuriakose J, Montezano AC, Touyz RM. ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease. Clinical Science (London, England : 1979). 135: 387-407. PMID 33511992 DOI: 10.1042/CS20200480  0.343
2020 Anagnostopoulou A, Camargo LL, Rodrigues D, Montezano AC, Touyz RM. Importance of cholesterol-rich microdomains in the regulation of Nox isoforms and redox signaling in human vascular smooth muscle cells. Scientific Reports. 10: 17818. PMID 33082354 DOI: 10.1038/s41598-020-73751-4  0.3
2020 Savoia C, Arrabito E, Parente R, Nicoletti C, Madaro L, Battistoni A, Filippini A, Steckelings UM, Touyz RM, Volpe M. Mas Receptor Activation Contributes to the Improvement of Nitric Oxide Bioavailability and Vascular Remodeling During Chronic AT1R (Angiotensin Type-1 Receptor) Blockade in Experimental Hypertension. Hypertension (Dallas, Tex. : 1979). 76: 1753-1761. PMID 33070664 DOI: 10.1161/HYPERTENSIONAHA.120.15527  0.342
2020 Rossitto G, Maiolino G, Lerco S, Ceolotto G, Blackburn G, Mary S, Antonelli G, Berton C, Bisogni V, Cesari M, Seccia TM, Lenzini L, Pinato A, Montezano A, Touyz RM, et al. High Sodium Intake, Glomerular Hyperfiltration and Protein Catabolism in Patients with Essential Hypertension. Cardiovascular Research. PMID 33053160 DOI: 10.1093/Cvr/Cvaa205  0.326
2020 Clark D, Dominiczak AF, Touyz RM, Barigou M, Zoghby Z, Jones DW. Woman With Polycystic Kidney Disease: The Role of Precision Medicine in Hypertension Management. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA12015. PMID 32951469 DOI: 10.1161/Hypertensionaha.120.15021  0.309
2020 Zou ZG, Rios F, Neves KB, Alves-Lopes R, Ling J, Baillie GS, Gao X, Fuller W, De Lucca Camargo L, Gudermann T, Chubanov V, Montezano AC, Touyz RM. Epidermal growth factor signaling through transient receptor potential melastatin 7 (TRPM7) cation channel regulates vascular smooth muscle cell function. Clinical Science (London, England : 1979). PMID 32706027 DOI: 10.1042/Cs20200827  0.348
2020 Zhao GJ, Zhao CL, Ouyang S, Deng KQ, Zhu L, Montezano AC, Zhang C, Hu F, Zhu XY, Tian S, Liu X, Ji YX, Zhang P, Zhang XJ, She ZG, ... Touyz RM, et al. Ca-Dependent NOX5 (NADPH Oxidase 5) Exaggerates Cardiac Hypertrophy Through Reactive Oxygen Species Production. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA12015. PMID 32683902 DOI: 10.1161/Hypertensionaha.120.15558  0.36
2020 Zanoli L, Briet M, Empana JP, Cunha PG, Mäki-Petäjä KM, Protogerou AD, Tedgui A, Touyz RM, Schiffrin EL, Spronck B, Bouchard P, Vlachopoulos C, Bruno RM, Boutouyrie P. Vascular consequences of inflammation: a position statement from the ESH Working Group on Vascular Structure and Function and the ARTERY Society. Journal of Hypertension. PMID 32649623 DOI: 10.1097/Hjh.0000000000002508  0.361
2020 Touyz RM, Rios FJ, Alves-Lopes R, Neves KB, Camargo LL, Montezano AC. Oxidative Stress: A Unifying Paradigm in Hypertension. The Canadian Journal of Cardiology. 36: 659-670. PMID 32389339 DOI: 10.1016/J.Cjca.2020.02.081  0.402
2020 Guzik TJ, Mohiddin SA, Dimarco A, Patel V, Savvatis K, Marelli-Berg FM, Madhur MS, Tomaszewski M, Maffia P, D'Acquisto F, Nicklin SA, Marian AJ, Nosalski R, Murray EC, Guzik B, ... ... Touyz RM, et al. COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Cardiovascular Research. PMID 32352535 DOI: 10.1093/Cvr/Cvaa106  0.336
2020 Touyz RM, Li H, Delles C. ACE2 the Janus-faced protein - from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19. Clinical Science. 134: 747-750. PMID 32255491 DOI: 10.1042/Cs20200363  0.305
2020 Bautista-Niño PK, Portilla-Fernandez E, Rubio-Beltrán E, van der Linden JJ, de Vries R, van Veghel R, de Boer M, Durik M, Ridwan Y, Brandt RMC, Essers J, Menzies RI, Thomas R, de Bruin A, Duncker DJ, ... ... Touyz RM, et al. Local endothelial dna repair defect causes aging-resembling endothelial-specific dysfunction. Clinical Science (London, England : 1979). PMID 32202295 DOI: 10.1042/Cs20190124  0.384
2020 Rodríguez JE, Saucedo-Campos AD, Vega AV, Ramírez-Hernández D, Martínez-Aguilar L, Jiménez-Flores JR, Andrade-Jorge E, Estrada-Soto SE, Villalobos-Molina R, Touyz RM, Gallardo-Ortíz IA. The α1D-adrenoreceptor antagonist BMY 7378 reverses cardiac hypertrophy in spontaneously hypertensive rats. Journal of Hypertension. PMID 32195823 DOI: 10.1097/Hjh.0000000000002412  0.396
2020 Deliyanti D, Alrashdi SF, Touyz RM, Kennedy CR, Jha JC, Cooper ME, Jandeleit-Dahm KA, Wilkinson-Berka JL. Nox (NADPH Oxidase) 1, Nox4, and Nox5 Promote Vascular Permeability and Neovascularization in Retinopathy. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA11914. PMID 32114846 DOI: 10.1161/Hypertensionaha.119.14100  0.384
2020 Llorens-Cortes C, Touyz RM. Evolution of a New Class of Antihypertensive Drugs: Targeting the Brain Renin-Angiotensin System. Hypertension. 75: 6-15. PMID 31786978 DOI: 10.1161/Hypertensionaha.119.12675  0.327
2020 Lucas-Herald AK, Alves-Lopes R, Haddow L, O’Toole S, Flett M, Amjad SB, Lee B, Steven M, Montezano AC, Ahmed SF, Touyz R. SUN-551 Impaired Vascular Relaxation and Altered eNOS Regulation in Boys with Hypospadias Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.1224  0.361
2020 Kuriakose J, Montezano AC, Hood KY, Alves-lopes R, Sin A, Passaglia P, Findlay J, Basheer S, Yusuf H, Hepburn R, Santos R, MacLean M, Baillie G, Touyz RM. Abstract P094: Crosstalk Between Mas And ET B R Elicits Protective Effects In Endothelial Cells And Vascular Function Hypertension. 76. DOI: 10.1161/Hyp.76.Suppl_1.P094  0.327
2020 Camargo LL, Montezano AC, Hussain M, Wang Y, Zou Z, Rios FJ, Neves K, Alves-lopes R, Awan F, Jensen T, Hartley R, Touyz RM. Abstract P090: Nox5 Induces Vascular Damage Through C-src Activation In Human Hypertension Hypertension. 76. DOI: 10.1161/Hyp.76.Suppl_1.P090  0.387
2020 Wang Y, Camargo L, Beatie W, McBride M, Montezano AC, Touyz RM. Abstract P085: Microrna Profiling Of Vascular Smooth Muscle Cells In Human Hypertension Potential Regulators Of Endoplasmic Reticulum And Oxidative Stress Hypertension. 76. DOI: 10.1161/Hyp.76.Suppl_1.P085  0.379
2020 Neves KB, Morris H, Alves-lopes R, Montezano AC, Touyz RM. Abstract MP31: Peripheral Vascular Dysfunction In A Model Of Small Vessel Disease Of The Brain (CADASIL) Involves Impaired Redox-sensitive Cyclic GMP/PKG Signaling Hypertension. 76. DOI: 10.1161/Hyp.76.Suppl_1.Mp31  0.325
2020 Alves-Lopes R, Neves KB, Harvey A, Montezano AC, Touyz RM. Abstract MP29: Activation Of Transient Receptor Potential Melastatin 2 (trpm2) Cation Channel Contributes To Nox4-induced Protective Effects In Endothelial Cells. Hypertension. 76. DOI: 10.1161/Hyp.76.Suppl_1.Mp29  0.335
2020 Rios FJ, Zou Z, Neves KB, Nichol SS, Camargo LL, Alves-lopes R, Chubanov V, Gudermann T, Montezano AC, Touyz RM. Abstract MP13: TRPM7 Downregulation Contributes To Cardiovascular Injury And Hypertension Induced By Aldosterone And Salt Hypertension. 76. DOI: 10.1161/Hyp.76.Suppl_1.Mp13  0.365
2019 Morris HE, Neves KB, Montezano AC, MacLean MR, Touyz RM. Notch3 signalling and vascular remodelling in pulmonary arterial hypertension. Clinical Science (London, England : 1979). 133: 2481-2498. PMID 31868216 DOI: 10.1042/Cs20190835  0.395
2019 Alves-Lopes R, Neves KB, Anagnostopoulou A, Rios FJ, Lacchini S, Montezano AC, Touyz RM. Crosstalk Between Vascular Redox and Calcium Signaling in Hypertension Involves TRPM2 (Transient Receptor Potential Melastatin 2) Cation Channel. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA11913. PMID 31735084 DOI: 10.1161/Hypertensionaha.119.13861  0.425
2019 Kelleher J, Dickinson A, Cain S, Hu Y, Bates N, Harvey A, Ren J, Zhang W, Moreton FC, Muir KW, Ward C, Touyz RM, Sharma P, Xu Q, Kimber SJ, et al. Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures. Stem Cell Reports. PMID 31680059 DOI: 10.1016/J.Stemcr.2019.10.004  0.348
2019 Connelly PJ, Marie Freel E, Perry C, Ewan J, Touyz RM, Currie G, Delles C. Gender-Affirming Hormone Therapy, Vascular Health and Cardiovascular Disease in Transgender Adults. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA11913. PMID 31656099 DOI: 10.1161/Hypertensionaha.119.13080  0.308
2019 Neves KB, Harvey AP, Moreton F, Montezano AC, Rios FJ, Alves-Lopes R, Nguyen Dinh Cat A, Rocchiccioli P, Delles C, Joutel A, Muir K, Touyz RM. ER stress and Rho kinase activation underlie the vasculopathy of CADASIL. Jci Insight. PMID 31647781 DOI: 10.1172/Jci.Insight.131344  0.377
2019 Mirabito Colafella KM, Neves KB, Montezano AC, Garrelds IM, van Veghel R, de Vries R, Uijl E, Baelde HJ, van den Meiracker AH, Touyz RM, Danser AHJ, Versmissen J. Selective ETA versus dual ETA/B receptor blockade for the prevention of sunitinib-induced hypertension and albuminuria in WKY rats. Cardiovascular Research. PMID 31593221 DOI: 10.1093/Cvr/Cvz260  0.378
2019 Arendse LB, Danser AHJ, Poglitsch M, Touyz RM, Burnett JC, Llorens-Cortes C, Ehlers MR, Sturrock ED. Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure. Pharmacological Reviews. 71: 539-570. PMID 31537750 DOI: 10.1124/Pr.118.017129  0.366
2019 Cameron AC, Welsh P, Neves KB, Newby DE, Touyz RM, Lang NN. Acute vascular effects of vascular endothelial growth factor inhibition in the forearm arterial circulation. Journal of Hypertension. PMID 31449168 DOI: 10.1097/Hjh.0000000000002230  0.396
2019 Rios FJ, Zou ZG, Harvey AP, Harvey KY, Nosalski R, Anyfanti P, Camargo LL, Lacchini S, Ryazanov AG, Ryazanova L, McGrath S, Guzik TJ, Goodyear CS, Montezano AC, Touyz RM. Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis. Cardiovascular Research. PMID 31250885 DOI: 10.1093/Cvr/Cvz164  0.352
2019 Jha JC, Dai A, Holterman CE, Cooper ME, Touyz RM, Kennedy CR, Jandeleit-Dahm KAM. Endothelial or vascular smooth muscle cell-specific expression of human NOX5 exacerbates renal inflammation, fibrosis and albuminuria in the Akita mouse. Diabetologia. PMID 31222503 DOI: 10.1007/S00125-019-4924-Z  0.368
2019 Beaney T, Burrell LM, Castillo RR, Charchar FJ, Cro S, Damasceno A, Kruger R, Nilsson PM, Prabhakaran D, Ramirez AJ, Schlaich MP, Schutte AE, Tomaszewski M, Touyz R, Wang JG, et al. May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension. European Heart Journal. PMID 31041440 DOI: 10.1093/Eurheartj/Ehz300  0.31
2019 Touyz RM. Hypertension Guidelines: Effect of Blood Pressure Targets Canadian Journal of Cardiology. 35: 564-569. PMID 31030859 DOI: 10.1016/J.Cjca.2019.03.014  0.35
2019 Zou Z, Rios FJ, Montezano AC, Touyz RM. TRPM7, Magnesium, and Signaling. International Journal of Molecular Sciences. 20: 1877. PMID 30995736 DOI: 10.3390/Ijms20081877  0.307
2019 Lerman LO, Kurtz TW, Touyz RM, Ellison DH, Chade AR, Crowley SD, Mattson DL, Mullins JJ, Osborn J, Eirin A, Reckelhoff JF, Iadecola C, Coffman TM. Animal Models of Hypertension: A Scientific Statement From the American Heart Association. Hypertension (Dallas, Tex. : 1979). HYP0000000000000090. PMID 30866654 DOI: 10.1161/Hyp.0000000000000090  0.361
2019 Touyz RM, Anagnostopoulou A, Rios F, Montezano AC, Camargo LL. Nox5: Molecular biology and pathophysiology. Experimental Physiology. PMID 30801870 DOI: 10.1113/Ep086204  0.329
2019 Neves KB, Rios FJ, Jones R, Jeffry Evans TR, Montezano AC, Touyz RM. Microparticles from VEGF inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research. PMID 30753341 DOI: 10.1093/Cvr/Cvz021  0.391
2019 Bruder-Nascimento T, Callera GE, Montezano AC, Chantemele EJBd, Tostes RC, Touyz RM. Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress. Life Sciences. 221: 29-34. PMID 30721707 DOI: 10.1016/J.Lfs.2019.01.043  0.404
2019 Ucci S, Battistoni A, Nicoletti C, Filippini A, Montezano AC, Volpe M, Touyz RM, Savoia C. Abstract P3005: P66shc Plays a Role in Aldosterone Induced Vascular Remodeling and Dysfunction Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.P3005  0.374
2019 Montezano AC, Camargo LL, Kuriakose J, Neves KB, Alves-Lopes R, Beattie W, Rios FJ, Touyz RM. Abstract P3002: Endoplasmic Reticulum Stress Plays a Role in Nox5 Mediated Vascular Contraction Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.P3002  0.341
2019 Rios FJ, Zou Z, Neves KB, Alves-Lopes R, Camargo LL, Montezano AC, Touyz RM. Abstract P197: TRPM7 is Involved in the Effects of VEGF and EGF in Vascular Cells Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.P197  0.355
2019 Morris HE, Neves KB, Nilsen M, Montezano AC, Joutel A, MacLean MR, Touyz RM. Abstract P145: Notch3 Mutation is Involved in Pulmonary Vascular Dysfunction and Development of Pulmonary Arterial Hypertension Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.P145  0.352
2019 Montezano AC, Sarafian RD, Neves KB, Rios FJ, Passaglia P, Camargo LL, Haddow L, Ford TJ, Dunne M, Alves-Lopes R, MacQuaide N, Berry C, Smith G, Touyz RM. Abstract 089: Role of Nox5 in Systemic Vascular Dysfunction in Ischemic Heart Disease Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.089  0.353
2019 Lucas-Herald A, Alves-Lopes R, Haddow L, O'Toole S, Amjad SB, Flett M, Lee B, Steven M, Pashova A, Montezano A, Ahmed SF, Touyz R. Abstract 074: Vascular Dysfunction in Boys With Androgen Insufficiency - Role of Nox5 and Calcium Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.074  0.325
2019 Camargo LL, Montezano AC, Wang Y, Hussain M, Awan FR, Rios FJ, Touyz RM. Abstract 068: Interplay Between Nox5 and Endoplasmic Reticulum Stress Regulates Vascular Signalling in Human Hypertension Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.068  0.366
2019 Rossitto G, Maiolino G, Lerco S, Ceolotto G, Blackburn G, Mary S, Antonelli G, Berton C, Bisogni V, Cesari M, Seccia TM, Lenzini L, Pinato A, Montezano A, Touyz RM, et al. Abstract 058: High Sodium Intake Induces a Catabolic State via Glomerular Hyperfiltration and Enhanced Glomerulotubular Balance in Essential Hypertension Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.058  0.336
2019 Neves KB, Morris H, Alves-Lopes R, Joutel A, Montezano AC, Touyz RM. Abstract 052: Rho Kinase and Endoplasmic Reticulum Stress Mediate Peripheral Vascular Dysfunction in a Model of Small Vessel Disease of the Brain Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.052  0.34
2019 Rios FJ, Zou Z, Hood KY, Harvey AP, Neves KB, Nichol SE, Camargo LL, Montezano AC, Touyz RM. Abstract 011: TRPM7 is Cardiovascular Protective in Aldosterone-Induced Hypertension Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.011  0.391
2018 Touyz RM, Anagnostopoulou A, Camargo L, Rios F, Montezano A. Vascular biology of superoxide-generating NADPH oxidase 5 (Nox5)- implications in hypertension and cardiovascular disease. Antioxidants & Redox Signaling. PMID 30334629 DOI: 10.1089/Ars.2018.7583  0.417
2018 Dobbin SJH, Cameron AC, Petrie MC, Jones RJ, Touyz RM, Lang NN. Toxicity of cancer therapy: what the cardiologist needs to know about angiogenesis inhibitors. Heart (British Cardiac Society). PMID 30228246 DOI: 10.1136/Heartjnl-2018-313726  0.366
2018 Neves KB, Nguyen Dinh Cat A, Alves-Lopes R, Harvey KY, da Costa RM, Lobato NS, Montezano AC, de Oliveira AM, Touyz RM, Tostes RC. Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways. American Journal of Physiology. Heart and Circulatory Physiology. PMID 30216119 DOI: 10.1152/Ajpheart.00285.2018  0.341
2018 Neves KB, Montezano AC, Alves-Lopes R, Bruder-Nascimento T, Costa RM, Costa RS, Touyz RM, Tostes RC. Upregulation of Nrf2 and Decreased Redox Signaling Contribute to Renoprotective Effects of Chemerin Receptor Blockade in Diabetic Mice. International Journal of Molecular Sciences. 19. PMID 30126255 DOI: 10.3390/Ijms19082454  0.318
2018 Poulter NR, Castillo R, Charchar FJ, Schlaich MP, Schutte AE, Tomaszewski M, Touyz RM, Wang JG. Are the American Heart Association/American College of Cardiology High Blood Pressure Guidelines Fit for Global Purpose?: Thoughts From the International Society of Hypertension. Hypertension (Dallas, Tex. : 1979). PMID 29967044 DOI: 10.1161/Hypertensionaha.118.11452  0.331
2018 Montezano AC, De Lucca Camargo L, Persson P, Rios FJ, Harvey AP, Anagnostopoulou A, Palacios R, Gandara ACP, Alves-Lopes R, Neves KB, Dulak-Lis M, Holterman CE, de Oliveira PL, Graham D, Kennedy C, ... Touyz RM, et al. NADPH Oxidase 5 Is a Pro-Contractile Nox Isoform and a Point of Cross-Talk for Calcium and Redox Signaling-Implications in Vascular Function. Journal of the American Heart Association. 7. PMID 29907654 DOI: 10.1161/Jaha.118.009388  0.352
2018 Rossitto G, Touyz R. Dr Giacomo Rossitto interviews Professor Rhian Touyz, on the translational applications of vascular smooth muscle cell biology in cardiovascular disease. Cardiovascular Research. 114. PMID 29897497 DOI: 10.1093/Cvr/Cvy081  0.336
2018 Camargo LL, Harvey AP, Rios FJ, Tsiropoulou S, Silva RNO, Cao Z, Graham D, McMaster C, Burchmore RJ, Hartley RC, Bulleid N, Montezano AC, Touyz RM. Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation, and Endoplasmic Reticulum Stress Response in Hypertension. Hypertension (Dallas, Tex. : 1979). PMID 29844144 DOI: 10.1161/Hypertensionaha.118.10824  0.392
2018 Touyz RM, Herrmann SMS, Herrmann J. Vascular toxicities with VEGF inhibitor therapies-focus on hypertension and arterial thrombotic events. Journal of the American Society of Hypertension : Jash. PMID 29703600 DOI: 10.1016/J.Jash.2018.03.008  0.405
2018 George MJ, Marks DJB, Rezk T, Breckenridge R, Sofat R, Martin J, MacAllister R, Touyz RM, Staessen JA, Bursztyn M, Lappin D, Barigou M, Hingorani A. Resistant Hypertension: Trials and Tribulations. Hypertension (Dallas, Tex. : 1979). PMID 29610269 DOI: 10.1161/Hypertensionaha.118.10864  0.309
2018 Bursztyn M, Touyz RM, Laffer CL, Carey RM, Dominiczak AF. Case of Severe Hypertension and Nephrotic Range Proteinuria. Hypertension (Dallas, Tex. : 1979). PMID 29610267 DOI: 10.1161/Hypertensionaha.118.11045  0.322
2018 Berra E, Dominiczak AF, Touyz RM, Pierard S, Hammer F, Rossi GP, Micali RG, Staessen JA, Bursztyn M, Kahan T, Persu A. Management of a Pregnant Woman With Fibromuscular Dysplasia Hypertension. 71: 540-547. PMID 29483231 DOI: 10.1161/Hypertensionaha.118.10819  0.333
2018 Neves KB, Rios FJ, van der Mey L, Alves-Lopes R, Cameron AC, Volpe M, Montezano AC, Savoia C, Touyz RM. VEGFR (Vascular Endothelial Growth Factor Receptor) Inhibition Induces Cardiovascular Damage via Redox-Sensitive Processes. Hypertension (Dallas, Tex. : 1979). PMID 29483228 DOI: 10.1161/Hypertensionaha.117.10490  0.456
2018 Almabrouk TAM, White AD, Ugusman AB, Skiba DS, Katwan OJ, Alganga H, Guzik TJ, Touyz RM, Salt IP, Kennedy S. High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion. Frontiers in Physiology. 9: 51. PMID 29479319 DOI: 10.3389/Fphys.2018.00051  0.303
2018 Nguyen Dinh Cat A, Callera GE, Friederich-Persson M, Sanchez A, Dulak-Lis MG, Tsiropoulou S, Montezano AC, He Y, Briones AM, Jaisser F, Touyz RM. Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling. Scientific Reports. 8: 2952. PMID 29440699 DOI: 10.1038/S41598-018-21087-5  0.351
2018 Liu P, Zhang S, Gao J, Lin Y, Shi G, He W, Touyz RM, Yan L, Huang H. Downregulated Serum 14, 15-Epoxyeicosatrienoic Acid Is Associated With Abdominal Aortic Calcification in Patients With Primary Aldosteronism. Hypertension (Dallas, Tex. : 1979). PMID 29440332 DOI: 10.1161/Hypertensionaha.117.10644  0.331
2018 Touyz RM, Alves-Lopes R, Rios FJ, Camargo LL, Anagnostopoulou A, Arner A, Montezano AC. Vascular Smooth Muscle Contraction in Hypertension. Cardiovascular Research. PMID 29394331 DOI: 10.1093/Cvr/Cvy023  0.443
2018 Touyz RM, Montezano AC. Angiotensin-(1-7) and Vascular Function: The Clinical Context. Hypertension. 71: 68-69. PMID 29203630 DOI: 10.1161/Hypertensionaha.117.10406  0.386
2018 Jha JC, Dai A, Cooper ME, Touyz RM, Kennedy C, Jandeleit-Dahm K. NADPH Oxidase Nox5 Aggravates Renal Injury in Akita Mouse Model of Diabetic Nephropathy Diabetes. 67. DOI: 10.2337/Db18-505-P  0.326
2018 Rossitto G, Maiolino G, Lerco S, Bisogni V, Cesari M, Ceolotto G, Touyz RM, Pinato A, Plebani M, Rossi GP, Delles C. Abstract P383: High Sodium Intake is Independently Associated with Subclinical Hypercortisolism in Hypertensive Patients Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.P383  0.321
2018 Alves-Lopes R, Neves KB, Anagnostopoulou A, Lacchini S, Montezano AC, Touyz RM. Abstract P153: Crosstalk Between Vascular Redox and Calcium Signalling in Hypertension Involves Transient Receptor Potential Melastatin 2 (TRPM2) Channel Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.P153  0.361
2018 Colafella KMM, Neves KB, Montezano AC, Veghel Rv, Garrelds IM, Baelde HJ, Meiracker AHvd, Touyz RM, Danser AJ, Versmissen J. Abstract P149: VEGF Inhibitor-Induced Hypertension and Renal Injury: Prevention by Aspirin? Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.P149  0.354
2018 Rios FJ, Zhi-guo Z, Camargo LL, Harvey AP, Lacchini S, Anyfanti P, McGrath S, Goodyear CS, Montezano AC, Touyz RM. Abstract 129: TRPM7 α-kinase Deficiency Causes Cardiovascular Inflammation and Fibrosis. Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.129  0.309
2018 Montezano AC, Camargo LL, Carrick E, Rios FJ, Haddow L, Beatie W, Holterman CE, Kennedy C, Touyz RM. Abstract 126: Nox5 Regulation of Vascular Contraction Involves Oxidation of Endoplasmic Reticulum Calcium Channels and Calreticulin Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.126  0.315
2018 Neves KB, Rios FJ, McLeod M, Hughes JD, Jones R, Evans J, Montezano A, Touyz RM. Abstract 049: Endothelial-Derived Microparticles as Biomarkers and Mediators of Endothelial Cell Injury in VEGF Inhibitor-Treated Cancer Patients: Implications in Hypertension Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.049  0.39
2018 Montezano A, Lacchini S, Alves-Lopes R, Harvey A, Rios FJ, Schroder K, Brandes RP, Touyz RM. A12666 Nox4 deficiency leads to hypertension and vascular damage with enhanced effects in Ang II-dependent hypertension Journal of Hypertension. 36. DOI: 10.1097/01.Hjh.0000548236.26946.8F  0.417
2018 Neves KB, Rios FJ, McLeod M, Hughes JD, Jones R, Montezano AC, Evans J, Touyz R. A10228 Endothelial microparticles from vegf inhibitor (vegfi)-treated cancer patients mediates endothelial cell signaling and et-1 production: implications in vegfi-induced hypertension Journal of Hypertension. 36. DOI: 10.1097/01.Hjh.0000548226.58333.97  0.378
2018 Lopes R, Neves K, Anagnostopoulou A, Lacchini S, Montezano AC, Touyz RM. A9595 Crosstalk Between Vascular Redox and Calcium Signalling in Hypertension Involves Transient Receptor Potential Melastatin 2 Channel Activation Journal of Hypertension. 36. DOI: 10.1097/01.Hjh.0000548217.61012.C0  0.319
2018 Huang H, Gao J, Feng L, Gao M, Zhuang X, Zhang K, Feng W, Wang J, Touyz RM, Liu P. A1146 Aldosterone facilitates high phosphate-induced vascular calcification via upregulation of osteogenic factors Journal of Hypertension. 36: e9. DOI: 10.1097/01.Hjh.0000548022.60938.D0  0.312
2017 Petrie JR, Guzik TJ, Touyz RM. Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms Canadian Journal of Cardiology. 34: 575-584. PMID 29459239 DOI: 10.1016/J.Cjca.2017.12.005  0.358
2017 Silva SD, Jara ZP, Peres R, Lima LS, Scavone C, Montezano AC, Touyz RM, Casarini DE, Michelini LC. Temporal changes in cardiac oxidative stress, inflammation and remodeling induced by exercise in hypertension: Role for local angiotensin II reduction. Plos One. 12: e0189535. PMID 29232407 DOI: 10.1371/Journal.Pone.0189535  0.345
2017 Dominiczak AF, Touyz RM. Hypertension Editors Welcome Comments From Regional Hypertension Societies Hypertension. 71: 962-962. PMID 29133353 DOI: 10.1161/Hypertensionaha.117.10427  0.353
2017 Savoia C, Volpe M, Grassi G, Borghi C, Rosei EA, Touyz RM. Personalized medicine-a modern approach for the diagnosis and management of hypertension. Clinical Science. 131: 2671-2685. PMID 29109301 DOI: 10.1042/Cs20160407  0.326
2017 Savoia C, Touyz RM. Hypertension, Diabetes Mellitus, and Excess Cardiovascular Risk Importance of Baseline Systolic Blood Pressure. Hypertension (Dallas, Tex. : 1979). PMID 28847887 DOI: 10.1161/Hypertensionaha.117.09764  0.35
2017 Guzik TJ, Skiba DS, Touyz RM, Harrison DG. The role of infiltrating immune cells in dysfunctional adipose tissue. Cardiovascular Research. 113: 1009-1023. PMID 28838042 DOI: 10.1093/Cvr/Cvx108  0.312
2017 Guzik TJ, Touyz RM. Oxidative Stress, Inflammation, and Vascular Aging in Hypertension. Hypertension. 70: 660-667. PMID 28784646 DOI: 10.1161/Hypertensionaha.117.07802  0.462
2017 Jha JC, Banal C, Okabe J, Gray SP, Hettige T, Chow BSM, Thallas-Bonke V, De Vos L, Holterman CE, Coughlan MT, Power DA, Skene A, Ekinci EI, Cooper ME, Touyz RM, et al. NADPH Oxidase-Nox5 Accelerates Renal Injury in Diabetic Nephropathy. Diabetes. PMID 28747378 DOI: 10.2337/Db16-1585  0.315
2017 Herald AKL, Alves-Lopes R, Montezano AC, Ahmed SF, Touyz RM. Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications. Clinical Science (London, England : 1979). 131: 1405-1418. PMID 28645930 DOI: 10.1042/Cs20170090  0.317
2017 Touyz RM, Lang NN, Herrmann J, van den Meiracker AH, Danser AHJ. Recent Advances in Hypertension and Cardiovascular Toxicities With Vascular Endothelial Growth Factor Inhibition. Hypertension (Dallas, Tex. : 1979). PMID 28630211 DOI: 10.1161/Hypertensionaha.117.08856  0.409
2017 Touyz RM, Montezano AC, Rios F, Widlansky ME, Liang M. Redox Stress Defines the Small Artery Vasculopathy of Hypertension: How Do We Bridge the Bench-to-Bedside Gap? Circulation Research. 120: 1721-1723. PMID 28546356 DOI: 10.1161/Circresaha.117.310672  0.431
2017 Tsiropoulou S, Touyz RM. Assessment of Protein Carbonylation and Protein Tyrosine Phosphatase (PTP) Oxidation in Vascular Smooth Muscle Cells (VSMCs) Using Immunoblotting Approaches. Methods in Molecular Biology (Clifton, N.J.). 1614: 31-46. PMID 28500593 DOI: 10.1007/978-1-4939-7030-8_3  0.351
2017 Harvey AP, Montezano AC, Hood KY, Lopes RA, Rios F, Ceravolo G, Graham D, Touyz RM. Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: The aldosterone-mineralocorticoid receptor-Nox1 axis. Life Sciences. PMID 28478264 DOI: 10.1016/J.Lfs.2017.05.002  0.422
2017 Hood KY, Mair KM, Harvey AP, Montezano AC, Touyz RM, MacLean MR. Serotonin Signaling Through the 5-HT1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 28473438 DOI: 10.1161/Atvbaha.116.308929  0.387
2017 Calvet D, Amar L, Rossi GP, Laurent S, Dominiczak AF, Turc G, Jennings G, Guzik T, Touyz RM. Case of Asymptomatic Carotid Artery Stenosis in a Hypertensive Patient. Hypertension (Dallas, Tex. : 1979). PMID 28461597 DOI: 10.1161/Hypertensionaha.117.09330  0.339
2017 Lee CJ, Kim BK, Yoon KB, Lee HY, Dominiczak AF, Touyz RM, Jennings GLR, Cho EJ, Hering D, Park S. Case of Refractory Hypertension Controlled by Repeated Renal Denervation and Celiac Plexus Block: A Case of Refractory Sympathetic Overload. Hypertension (Dallas, Tex. : 1979). PMID 28416585 DOI: 10.1161/Hypertensionaha.117.09260  0.331
2017 Daniels S, Cappuccio FP, Lisheng L, Kaczorowski J, Jula A, Atrey A, Touyz R, Correa-Rotter R, Weber M, Webster J, Legetic B, Campbell N, Hankey G, Waqanivalu T, Anderson C, et al. Recommended standards for assessing blood pressure in human research where blood pressure or hypertension is a major focus Journal of Human Hypertension. 31: 487-490. PMID 28406234 DOI: 10.1038/Jhh.2017.10  0.306
2017 Amar L, Sharabi Y, Rossi GP, Vidal-Petiot E, Dominiczak AF, Mulatero P, Faucon A, Dhaun N, Touyz RM, Barigou M, Lorthioir A. Case of Primary Aldosteronism With Discordant Hormonal and Computed Tomographic Findings. Hypertension. 69: 529-535. PMID 28193708 DOI: 10.1161/Hypertensionaha.116.08751  0.329
2017 Montezano AC, Lopes RAM, Neves KB, Rios F, Touyz RM. Isolation and Culture of Vascular Smooth Muscle Cells from Small and Large Vessels Methods of Molecular Biology. 1527: 349-354. PMID 28116729 DOI: 10.1007/978-1-4939-6625-7_27  0.325
2017 Skiba DS, Nosalski R, Mikolajczyk TP, Siedlinski M, Rios FJ, Montezano AC, Jawien J, Olszanecki R, Korbut R, Czesnikiewicz-Guzik M, Touyz RM, Guzik TJ. Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis British Journal of Pharmacology. 174: 4055-4069. PMID 27935022 DOI: 10.1111/Bph.13685  0.342
2017 Neves KB, Rios FJ, Montezano AC, Mey LVD, Savoia C, Touyz R. 224 Vascular endothelial growth factor receptor inhibition induces vascular dysfunction via redox-sensitive processes Heart. 103. DOI: 10.1136/Heartjnl-2017-311726.222  0.45
2017 Montezano A, Lopes RA, Neves K, Graham D, Touyz RM. 182 Syndecan-1 is involved in osteoprotegerin-induced vascular dysfunction Heart. 103. DOI: 10.1136/Heartjnl-2017-311726.180  0.365
2017 Camargo LdL, Montezano AC, Tsiropoulou S, Harvey A, Hood K, Cao Z, Burchmore R, Bulleid N, Touyz R. 181 Nox compartmentalization and protein oxidation in vascular smooth muscle cells – implications in vascular dysfunction in hypertension Heart. 103. DOI: 10.1136/Heartjnl-2017-311726.179  0.422
2017 Montezano A, Lopes R, Neves K, Graham D, Touyz RM. 170 Fetuin-a induces nox1-ros-dependent vascular dysfunction partially through toll like receptor 4 activation Heart. 103. DOI: 10.1136/Heartjnl-2017-311726.168  0.413
2017 Alves-Lopes R, Montezano AC, Neves KB, Anagnostopoulou A, Lacchini S, Touyz RM. 159 Trpm2 ion channel activation contributes to redox-sensitive vascular dysfunction in hypertension Heart. 103. DOI: 10.1136/Heartjnl-2017-311726.158  0.395
2017 Montezano A, Harvey A, Rios F, Beatie W, McPherson L, Thomson J, Holterman CE, Kennedy C, Touyz RM. 151 Nox5 induces vascular dysfunction and arterial remodelling independently of blood pressure elevation in ang ii-infused nox5-expressing mice Heart. 103. DOI: 10.1136/Heartjnl-2017-311726.150  0.418
2017 Anagnostopoulou A, Persson P, Montezano A, Touyz R. 23 NADPH OXIDASE 5 (NOX5), cholesterol-rich microdomains and ANG II signallingsignaling in human primary vascular smooth muscle cells Heart. 103. DOI: 10.1136/Heartjnl-2017-311433.23  0.421
2017 Lacchini S, Harvey A, Lopes R, Montezano AC, Rios F, Schroder K, Brandes RP, Touyz RM. [Bp.10.02] Nox4 Deficiency Leads To Hypertension And Vascular-Renal Fibrosis With Enhanced Effects In Ang Ii-Dependent Hypertension Journal of Hypertension. 35. DOI: 10.1097/01.Hjh.0000524022.64767.23  0.429
2017 Neves K, Rios F, Montezano A, Mey LVD, Small H, Savoia C, Touyz R. [Pp.22.23] Vascular Endothelial Growth Factor Receptor Inhibition Induces Vascular Dysfunction Via Redox-Sensitive And Nitric Oxide-Dependent Pathways Journal of Hypertension. 35. DOI: 10.1097/01.Hjh.0000523824.20400.A3  0.394
2017 Hood KY, Mair KM, Harvey AP, Montezano AC, Touyz RM, MacLean MR. P4919Serotonin signaling through the 5-HT1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension European Heart Journal. 38. DOI: 10.1093/Eurheartj/Ehx493.P4919  0.347
2017 Cat AND, Friederich-Persson M, Dulak M, Sanchez A, Jaisser F, Touyz R. Increased ROS generation involves mitochondria in MR-overexpressing adipocytes – impact on vascular function Archives of Cardiovascular Diseases Supplements. 9: 187. DOI: 10.1016/S1878-6480(17)30464-0  0.334
2016 Martínez-Revelles S, Garcia-Redondo AB, Avendaño MS, Varona S, Palao T, Orriols M, Roque FR, Fortuño A, Touyz RM, Martínez-Gonzalez J, Salaices M, Rodríguez C, Briones AM. Lysyl oxidase induces vascular oxidative stress and contributes to arterial stiffness and abnormal elastin structure in hypertension: role of p38MAPK. Antioxidants & Redox Signaling. PMID 28010122 DOI: 10.1089/Ars.2016.6642  0.377
2016 Fattah C, Nather K, McCarroll CS, Hortigon-Vinagre MP, Zamora V, Flores-Munoz M, McArthur L, Zentilin L, Giacca M, Touyz RM, Smith GL, Loughrey CM, Nicklin SA. Gene Therapy With Angiotensin-(1-9) Preserves Left Ventricular Systolic Function After Myocardial Infarction. Journal of the American College of Cardiology. 68: 2652-2666. PMID 27978950 DOI: 10.1016/J.Jacc.2016.09.946  0.306
2016 Cunha AR, D'El-Rei J, Medeiros F, Umbelino B, Oigman W, Touyz RM, Neves MF. Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women. Journal of Hypertension. PMID 27759579 DOI: 10.1097/Hjh.0000000000001129  0.354
2016 Cameron AC, Lang NN, Touyz RM. Drug Treatment of Hypertension: Focus on Vascular Health. Drugs. PMID 27667708 DOI: 10.1007/S40265-016-0642-8  0.442
2016 Harvey AP, Montezano A, Wong KC, Hood KY, Alves-Lopes R, Ceravolo GS, Yabe-Nishimura C, Graham D, Touyz RM. OS 02-01 ROLE OF ALDOSTERONE AND NADPH OXIDASE 1 IN HYPERTENSION-ASSOCIATED VASCULAR AGING. Journal of Hypertension. 34: e48. PMID 27643247 DOI: 10.1097/01.Hjh.0000499976.25294.9E  0.388
2016 Callera GE, Antunes TT, He Y, Montezano AC, Yogi A, Savoia C, Touyz RM. c-Src Inhibition Improves Cardiovascular Function but not Remodeling or Fibrosis in Angiotensin II-Induced Hypertension. Hypertension (Dallas, Tex. : 1979). PMID 27620391 DOI: 10.1161/Hypertensionaha.116.07699  0.399
2016 Alves-Lopes R, Neves KB, Montezano AC, Harvey A, Carneiro FS, Touyz RM, Tostes RC. Internal Pudental Artery Dysfunction in Diabetes Mellitus Is Mediated by NOX1-Derived ROS-, Nrf2-, and Rho Kinase-Dependent Mechanisms. Hypertension (Dallas, Tex. : 1979). PMID 27528061 DOI: 10.1161/Hypertensionaha.116.07518  0.4
2016 Campbell NR, Lackland DT, Niebylski ML, Orias M, Redburn KA, Nilsson PM, Zhang XH, Burrell L, Horiuchi M, Poulter NR, Prabhakaran D, Ramirez AJ, Schiffrin EL, Schutte AE, Touyz RM, et al. 2016 Dietary Salt Fact Sheet and Call to Action: The World Hypertension League, International Society of Hypertension, and the International Council of Cardiovascular Prevention and Rehabilitation. Journal of Clinical Hypertension (Greenwich, Conn.). PMID 27515460 DOI: 10.1111/Jch.12894  0.359
2016 Onwubere B, Coca A, Damasceno A, Kadiri S, Kruger R, Lemogoum D, M'Buyamba-Kabangu JR, Okpechi I, Poulter N, Rayner B, Seedat YK, Schutte AE, Touyz RM. Report of the International Society of Hypertension Teaching Seminar organized by the International Society of Hypertension Africa Regional Advisory Group: Maputo, Mozambique, 2016. Journal of Hypertension. PMID 27467769 DOI: 10.1097/Hjh.0000000000001062  0.326
2016 Valinsky WC, Jolly A, Miquel P, Touyz RM, Shrier A. Aldosterone Upregulates Transient Receptor Potential Melastatin 7 (TRPM7). The Journal of Biological Chemistry. PMID 27466368 DOI: 10.1074/Jbc.M116.735175  0.313
2016 Touyz RM. Lower is better in hypertension, but how low should blood pressure be targeted? Journal of the American Society of Hypertension. 10: 621-622. PMID 27436128 DOI: 10.1016/J.Jash.2016.06.028  0.325
2016 Hood KY, Montezano AC, Harvey AP, Nilsen M, MacLean MR, Touyz RM. Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Mediated Redox Signaling and Vascular Remodeling by 16α-Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial Hypertension. Hypertension. PMID 27402919 DOI: 10.1161/Hypertensionaha.116.07668  0.42
2016 Weber MA, Poulter NR, Schutte AE, Burrell LM, Horiuchi M, Prabhakaran D, Ramirez AJ, Wang JG, Schiffrin EL, Touyz RM. Is It Time to Reappraise Blood Pressure Thresholds and Targets? A Statement From the International Society of Hypertension-A Global Perspective. Hypertension. PMID 27354426 DOI: 10.1161/Hypertensionaha.116.07818  0.347
2016 Campbell NR, Khalsa T, Lackland DT, Niebylski ML, Nilsson PM, Redburn KA, Orias M, Zhang XH, Burrell L, Horiuchi M, Poulter NR, Prabhakaran D, Ramirez AJ, ... ... Touyz RM, et al. High Blood Pressure 2016: Why Prevention and Control Are Urgent and Important. The World Hypertension League, International Society of Hypertension, World Stroke Organization, International Diabetes Foundation, International Council of Cardiovascular Prevention and Rehabilitation, International Society of Nephrology. Journal of Clinical Hypertension (Greenwich, Conn.). PMID 27316336 DOI: 10.1111/Jch.12840  0.333
2016 Burger D, Turner M, Munkonda MN, Touyz RM. Endothelial Microparticle-Derived Reactive Oxygen Species: Role in Endothelial Signaling and Vascular Function. Oxidative Medicine and Cellular Longevity. 2016: 5047954. PMID 27313830 DOI: 10.1155/2016/5047954  0.398
2016 Cat AN, Antunes TT, Callera GE, Sanchez A, Tsiropoulou S, Dulak-Lis MG, Anagnostopoulou A, He Y, Montezano AC, Jaisser F, Touyz RM. Adipocyte-specific mineralocorticoid receptor overexpression in mice is associated with metabolic syndrome and vascular dysfunction - role of redox-sensitive PKG-1 and Rho kinase. Diabetes. PMID 27207514 DOI: 10.2337/Db15-1627  0.396
2016 Johansen AK, Dean A, Morecroft I, Hood K, Nilsen M, Loughlin L, Anagnostopoulou A, Touyz RM, White K, MacLean MR. The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1. Pulmonary Circulation. 6: 82-92. PMID 27162617 DOI: 10.1086/685023  0.347
2016 Harvey A, Montezano AC, Lopes RA, Rios F, Touyz RM. Vascular Fibrosis in Aging and Hypertension: Molecular Mechanisms and Clinical Implications. The Canadian Journal of Cardiology. 32: 659-68. PMID 27118293 DOI: 10.1016/J.Cjca.2016.02.070  0.433
2016 Touyz RM, Dominiczak AF. Hypertension Guidelines: Is It Time to Reappraise Blood Pressure Thresholds and Targets? Hypertension. 67: 688-9. PMID 26962205 DOI: 10.1161/Hypertensionaha.116.07090  0.347
2016 Rios F, Alves R, Neves K, Camargo L, Montezano A, Touyz RM. Off-target vascular effects of cholesteryl ester transfer protein (CETP) inhibitors involve redox-sensitive and STAT3-dependent pathways. The Journal of Pharmacology and Experimental Therapeutics. PMID 26941168 DOI: 10.1124/Jpet.115.230748  0.393
2016 Antunes TT, Callera GE, He Y, Yogi A, Ryazanov AG, Ryazanova LV, Zhai A, Stewart DJ, Shrier A, Touyz RM. Transient Receptor Potential Melastatin 7 Cation Channel Kinase: New Player in Angiotensin II-Induced Hypertension. Hypertension. PMID 26928801 DOI: 10.1161/Hypertensionaha.115.07021  0.43
2016 Gray SP, Di Marco E, Kennedy K, Chew P, Okabe J, El-Osta A, Calkin AC, Biessen EA, Touyz RM, Cooper ME, Schmidt HH, Jandeleit-Dahm KA. Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology. 36: 295-307. PMID 26715682 DOI: 10.1161/Atvbaha.115.307012  0.324
2016 Rios FJ, Harvey A, Lopes RA, Montezano AC, Touyz RM. Progenitor Cells, Bone Marrow-Derived Fibrocytes and Endothelial-to-Mesenchymal Transition: New Players in Vascular Fibrosis. Hypertension. 67: 272-4. PMID 26693817 DOI: 10.1161/Hypertensionaha.115.06220  0.433
2016 Aguado A, Fischer T, Rodríguez C, Manea A, Martínez-González J, Touyz RM, Hernanz R, Alonso MJ, Dixon DA, Briones AM, Salaices M. Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells. Journal of Hypertension. 34: 253-65. PMID 26682942 DOI: 10.1097/Hjh.0000000000000801  0.352
2016 Touyz RM, Dominiczak AF. Successes of SPRINT, but Still Some Hurdles to Cross. Hypertension. 67: 268-9. PMID 26556815 DOI: 10.1161/Hypertensionaha.115.06725  0.347
2016 Touyz RM. Ish Pre-2 The Vascular Phenotype In Hypertension - Molecular Mechanisms And Clinical Implications. Journal of Hypertension. 34. DOI: 10.1097/01.Hjh.0000500981.45271.77  0.376
2016 Hood KY, Yusuf H, Findlay JE, Santos RA, Castro CH, Baillie GS, Montezano AC, MacLean MR, Touyz RM. Js Ish-Eccr-2 Ang-(1-7) And Et-1, A New Partnership. Journal of Hypertension. 34. DOI: 10.1097/01.Hjh.0000500977.99529.Fe  0.361
2016 Tsiropoulou S, Montezano A, Scott A, Burchmore RJ, Touyz RM. Ps 07-14 Vascular Protein Oxidation And Redox Proteomics In Hypertension Journal of Hypertension. 34. DOI: 10.1097/01.Hjh.0000500678.85921.Bc  0.378
2016 Rios FJ, Hood KY, Karvey A, Neves KB, Anyfanti P, Nosalski R, Ll LLC, Montezano AC, Touyz RM. Os 21-03 Effects Of The Trpm7 Kinase Domain In Vascular Dysfunction And Cardiac Fibrosis Induced By Aldosterone And Salt. Journal of Hypertension. 34. DOI: 10.1097/01.Hjh.0000500522.35716.8B  0.41
2016 Hood KY, Yusuf H, Findlay JE, Santos RA, Castro CH, Baillie GS, MacLean MR, Montezano A, Touyz RM. OS 15-08 Ang(1-7) INFLUENCES ET-1 SIGNALING THROUGH MAS: ETBR INTERACTIONS: IMPLICATIONS IN PULMONARY HYPERTENSION. Journal of Hypertension. 34. DOI: 10.1097/01.Hjh.0000500475.07008.Db  0.38
2016 Touyz RM. Poa 02-3 Small Vessel Disease And Hypertension – Molecular Mechanisms And Clinical Implications Journal of Hypertension. 34. DOI: 10.1097/01.Hjh.0000499945.48233.Ea  0.422
2016 Cat AND, Friederich-Persson M, Dulak-Lis MG, Sanchez A, Nosalski R, Montezano AC, Guzik TJ, Jaisser F, Touyz RM. [Pp.03.16] Increased Ros Generation Involves Mitochondria In Mr-Overexpressing Adipocytes – Impact On Vascular Function. Journal of Hypertension. 34. DOI: 10.1097/01.Hjh.0000491683.72231.5D  0.336
2016 White A, Cat AND, Montezano A, Salt I, Touyz R. AMPK as a therapeutic target for metabolic disorders: interactions with the renin–angiotensin–aldosterone system in adipocytes The Lancet. 387. DOI: 10.1016/S0140-6736(16)00492-X  0.363
2015 Cameron AC, Touyz RM, Lang NN. Vascular Complications of Cancer Chemotherapy. The Canadian Journal of Cardiology. PMID 26968393 DOI: 10.1016/J.Cjca.2015.12.023  0.357
2015 Gallardo‐Ortíz IA, Rodríguez‐Hernández SN, López‐Guerrero JJ, Valle‐Mondragón LD, López‐Sánchez P, Touyz RM, Villalobos‐Molina R. Role of α1D -adrenoceptors in vascular wall hypertrophy during angiotensin II-induced hypertension. Autonomic and Autacoid Pharmacology. 35: 17-31. PMID 26845248 DOI: 10.1111/Aap.12035  0.424
2015 Currie G, Delles C, Touyz RM, Staessen JA, Dominiczak AF, Jennings GL, Wang JG. A Woman With Treatment-Resistant Hypertension. Hypertension. PMID 26711735 DOI: 10.1161/Hypertensionaha.115.06756  0.344
2015 Messaoudi S, He Y, Gutsol A, Wight A, Hébert RL, Vilmundarson RO, Makrigiannis AP, Chalmers J, Hamet P, Tremblay J, McPherson R, Stewart AF, Touyz RM, Nemer M. Endothelial Gata5 transcription factor regulates blood pressure. Nature Communications. 6: 8835. PMID 26617239 DOI: 10.1038/Ncomms9835  0.432
2015 Lopes RA, Neves KB, Tostes RC, Montezano AC, Touyz RM. Downregulation of Nuclear Factor Erythroid 2-Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension. Hypertension. 66: 1240-50. PMID 26503970 DOI: 10.1161/Hypertensionaha.115.06163  0.445
2015 Silva MA, Bruder-Nascimento T, Cau SB, Lopes RA, Mestriner FL, Fais RS, Touyz RM, Tostes RC. Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling. Frontiers in Physiology. 6: 269. PMID 26500555 DOI: 10.3389/Fphys.2015.00269  0.393
2015 Kolisek M, Montezano AC, Sponder G, Anagnostopoulou A, Vormann J, Touyz RM, Aschenbach JR. PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases. Clinical Science (London, England : 1979). 129: 1143-50. PMID 26453619 DOI: 10.1042/Cs20150355  0.315
2015 Touyz RM. The Neuroimmune Axis in the Kidney: Role in Hypertension. Circulation Research. 117: 487-9. PMID 26316603 DOI: 10.1161/Circresaha.115.307176  0.344
2015 Montezano AC, Tsiropoulou S, Dulak-Lis M, Harvey A, Camargo Lde L, Touyz RM. Redox signaling, Nox5 and vascular remodeling in hypertension. Current Opinion in Nephrology and Hypertension. 24: 425-33. PMID 26197203 DOI: 10.1097/Mnh.0000000000000153  0.437
2015 Neves KB, Nguyen Dinh Cat A, Lopes RA, Rios FJ, Anagnostopoulou A, Lobato NS, de Oliveira AM, Tostes RC, Montezano AC, Touyz RM. Chemerin Regulates Crosstalk Between Adipocytes and Vascular Cells Through Nox. Hypertension. 66: 657-66. PMID 26150435 DOI: 10.1161/Hypertensionaha.115.05616  0.423
2015 Burger D, Viñas JL, Akbari S, Dehak H, Knoll W, Gutsol A, Touyz RM, Allan DS, Burns KD. Human Endothelial Colony-Forming Cells Protect against Acute Kidney Injury: Role of Exosomes. The American Journal of Pathology. PMID 26073035 DOI: 10.1016/J.Ajpath.2015.04.010  0.345
2015 Silva MA, Cau SB, Lopes RA, Manzato CP, Neves KB, Bruder-Nascimento T, Mestriner FL, Montezano AC, Cat AN, Touyz RM, Tostes RC. Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus. Clinical Science (London, England : 1979). 129: 533-45. PMID 25967696 DOI: 10.1042/Cs20140758  0.368
2015 Montezano AC, Dulak-Lis M, Tsiropoulou S, Harvey A, Briones AM, Touyz RM. Oxidative Stress and Human Hypertension: Vascular Mechanisms, Biomarkers, and Novel Therapies. The Canadian Journal of Cardiology. 31: 631-641. PMID 25936489 DOI: 10.1016/J.Cjca.2015.02.008  0.422
2015 Harvey A, Montezano AC, Touyz RM. Vascular biology of ageing-Implications in hypertension. Journal of Molecular and Cellular Cardiology. 83: 112-121. PMID 25896391 DOI: 10.1016/J.Yjmcc.2015.04.011  0.414
2015 Campbell N, Touyz R, Lackland D, Redburn K, Niebylski M. Celebrate World Hypertension Day (WHD) on May 17, 2015, and contribute to improving awareness of hypertension. Journal of Clinical Hypertension (Greenwich, Conn.). 17: 317-8. PMID 25808252 DOI: 10.1111/Jch.12542  0.31
2015 Chignalia AZ, Oliveira MA, Debbas V, Dull RO, Laurindo FR, Touyz RM, Carvalho MH, Fortes ZB, Tostes RC. Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms. Clinical Science (London, England : 1979). 129: 39-48. PMID 25700020 DOI: 10.1042/Cs20140548  0.364
2015 Zimmerman DL, Zimpelmann J, Xiao F, Gutsol A, Touyz R, Burns KD. The effect of angiotensin-(1-7) in mouse unilateral ureteral obstruction American Journal of Pathology. 185: 729-740. PMID 25625676 DOI: 10.1016/J.Ajpath.2014.11.013  0.323
2015 Rios FJ, Neves KB, Nguyen Dinh Cat A, Even S, Palacios R, Montezano AC, Touyz RM. Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes. The Journal of Pharmacology and Experimental Therapeutics. 353: 27-34. PMID 25617244 DOI: 10.1124/Jpet.114.221002  0.32
2015 Touati S, Montezano AC, Meziri F, Riva C, Touyz RM, Laurant P. Exercise training protects against atherosclerotic risk factors through vascular NADPH oxidase, extracellular signal-regulated kinase 1/2 and stress-activated protein kinase/c-Jun N-terminal kinase downregulation in obese rats. Clinical and Experimental Pharmacology & Physiology. 42: 179-85. PMID 25399833 DOI: 10.1111/1440-1681.12338  0.31
2015 Bruder-Nascimento T, Callera GE, Montezano AC, He Y, Antunes TT, Cat AN, Tostes RC, Touyz RM. Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways. Clinical Science (London, England : 1979). 128: 411-23. PMID 25358739 DOI: 10.1042/Cs20140456  0.392
2015 Tsiropoulou S, Montezano A, Scott A, Burchmore R, Touyz R. 41 Vascular protein oxidation and redox proteomics in human hypertension Heart. 101. DOI: 10.1136/Heartjnl-2015-308734.41  0.344
2015 Rios F, Montezano A, Mey LVD, Small H, Savoia C, Touyz R. 39 Molecular mechanisms of VEGFR inhibition-induced endothelial cell damage Heart. 101. DOI: 10.1136/Heartjnl-2015-308734.39  0.403
2015 Neves K, Lopes R, Leckerman S, Strembitska A, Jenkins C, Thomson J, Graham D, Touyz R, Montezano A. 35 Fetuin-A and toll-like receptor 4 regulate vascular function: role of Nox1 Heart. 101. DOI: 10.1136/Heartjnl-2015-308734.35  0.429
2015 Harvey A, Montezano A, Hood K, Lopes R, Ceravolo G, Yabe-Nishimura C, Graham D, Touyz R. 32 Premature vascular ageing in hypertension: role of aldosterone and nadph oxidases Heart. 101. DOI: 10.1136/Heartjnl-2015-308734.32  0.415
2015 Hood KY, Yusuf H, Findlay JE, Santos RA, Castro CH, Baillie GS, Montezano AC, MacLean MR, Touyz RM. 3 Angiotensin 1–7 regulation of endothelin-1 system in pulmonary hypertension Heart. 101. DOI: 10.1136/Heartjnl-2015-308734.3  0.361
2015 Nather K, Nicklin SA, Loughrey CM, Touyz RM, Flores-Muñoz M, Wills L. 195 Angiotensin-(1-9) Reduces Cardiac Dysfunction in a Model of Angiotensin II-Induced Hypertensive Heart Disease Heart. 101. DOI: 10.1136/Heartjnl-2015-308066.195  0.376
2014 Even SE, Dulak-Lis MG, Touyz RM, Nguyen Dinh Cat A. Crosstalk between adipose tissue and blood vessels in cardiometabolic syndrome: implication of steroid hormone receptors (MR/GR). Hormone Molecular Biology and Clinical Investigation. 19: 89-101. PMID 25390018 DOI: 10.1515/Hmbci-2014-0013  0.368
2014 Ceravolo GS, Montezano AC, Jordão MT, Akamine EH, Costa TJ, Takano AP, Fernandes DC, Barreto-Chaves ML, Laurindo FR, Tostes RC, Fortes ZB, Chopard RP, Touyz RM, Carvalho MH. An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin II-induced hypertension: in vivo and in vitro studies. Plos One. 9: e111117. PMID 25369284 DOI: 10.1371/Journal.Pone.0111117  0.403
2014 Beattie CJ, Fulton RL, Higgins P, Padmanabhan S, McCallum L, Walters MR, Dominiczak AF, Touyz RM, Dawson J. Allopurinol initiation and change in blood pressure in older adults with hypertension. Hypertension. 64: 1102-7. PMID 25135183 DOI: 10.1161/Hypertensionaha.114.03953  0.339
2014 Touyz RM. Linking LOX-1 and arginase II through mitochondria: a novel paradigm in endothelial dysfunction. Circulation Research. 115: 412-4. PMID 25081132 DOI: 10.1161/Circresaha.114.304550  0.45
2014 Zimmerman DL, Ruzicka M, Hebert P, Fergusson D, Touyz RM, Burns KD. Short daily versus conventional hemodialysis for hypertensive patients: a randomized cross-over study. Plos One. 9: e97135. PMID 24875804 DOI: 10.1371/Journal.Pone.0097135  0.358
2014 Small HY, Montezano AC, Rios FJ, Savoia C, Touyz RM. Hypertension due to antiangiogenic cancer therapy with vascular endothelial growth factor inhibitors: understanding and managing a new syndrome. The Canadian Journal of Cardiology. 30: 534-43. PMID 24786444 DOI: 10.1016/J.Cjca.2014.02.011  0.44
2014 Montezano AC, Nguyen Dinh Cat A, Rios FJ, Touyz RM. Angiotensin II and vascular injury. Current Hypertension Reports. 16: 431. PMID 24760441 DOI: 10.1007/S11906-014-0431-2  0.446
2014 Gonzaga NA, Callera GE, Yogi A, Mecawi AS, Antunes-Rodrigues J, Queiroz RH, Touyz RM, Tirapelli CR. Acute ethanol intake induces mitogen-activated protein kinase activation, platelet-derived growth factor receptor phosphorylation, and oxidative stress in resistance arteries. Journal of Physiology and Biochemistry. 70: 509-23. PMID 24733165 DOI: 10.1007/S13105-014-0331-6  0.327
2014 Montezano AC, Touyz RM. Mammalian target of rapamycin: a novel pathway in vascular calcification. The Canadian Journal of Cardiology. 30: 482-4. PMID 24698657 DOI: 10.1016/J.Cjca.2014.03.001  0.323
2014 Jha JC, Gray SP, Barit D, Okabe J, El-Osta A, Namikoshi T, Thallas-Bonke V, Wingler K, Szyndralewiez C, Heitz F, Touyz RM, Cooper ME, Schmidt HH, Jandeleit-Dahm KA. Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy. Journal of the American Society of Nephrology : Jasn. 25: 1237-54. PMID 24511132 DOI: 10.1681/Asn.2013070810  0.312
2014 Burger D, Reudelhuber TL, Mahajan A, Chibale K, Sturrock ED, Touyz RM. Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension. Clinical Science (London, England : 1979). 127: 57-63. PMID 24506807 DOI: 10.1042/Cs20130808  0.325
2014 Bruder-Nascimento T, Chinnasamy P, Riascos-Bernal DF, Cau SB, Callera GE, Touyz RM, Tostes RC, Sibinga NES. Angiotensin II induces Fat1 expression/activation and vascular smooth muscle cell migration via Nox1-dependent reactive oxygen species generation Journal of Molecular and Cellular Cardiology. 66: 18-26. PMID 24445059 DOI: 10.1016/J.Yjmcc.2013.10.013  0.393
2014 Campbell NRC, Lackland DT, Chockalingam A, Lisheng L, Harrap SB, Touyz RM, Burrell LM, Ramírez AJ, Schmieder RE, Schutte AE, Prabhakaran D, Schiffrin EL. The International Society of Hypertension and World Hypertension League call on governments, nongovernmental organizations and the food industry to work to reduce dietary sodium. Journal of Hypertension. 32: 446-447. PMID 24430121 DOI: 10.1097/Hjh.0000000000000079  0.346
2014 Campbell N, Lackland D, Chockalingam A, Lisheng L, Schiffrin EL, Harrap S, Touyz RM, Burrell L, Ramírez A, Schmieder R, Aletta S, Prabhakaran D. The World Hypertension League and International Society of Hypertension Call on Governments, Nongovernmental Organizations, and the Food Industry to Work to Reduce Dietary Sodium Journal of Clinical Hypertension. 16: 99-100. PMID 24422889 DOI: 10.1111/Jch.12245  0.3
2014 Jennings GL, Touyz RM. Response to European Society of Hypertension and European Society of Cardiology guidelines and the muted enthusiasm for home blood pressure monitoring. Hypertension. 63: e6. PMID 24402085 DOI: 10.1161/Hypertensionaha.113.02423  0.316
2014 Weber MA, Schiffrin EL, White WB, Mann S, Lindholm LH, Kenerson JG, Flack JM, Carter BL, Materson BJ, Ram CV, Cohen DL, Cadet JC, Jean-Charles RR, Taler S, Kountz D, ... ... Touyz RM, et al. Clinical practice guidelines for the management of hypertension in the community: a statement by the American Society of Hypertension and the International Society of Hypertension. Journal of Clinical Hypertension (Greenwich, Conn.). 16: 14-26. PMID 24341872 DOI: 10.1111/Jch.12237  0.31
2014 Di Marco E, Gray SP, Chew P, Koulis C, Ziegler A, Szyndralewiez C, Touyz RM, Schmidt HH, Cooper ME, Slattery R, Jandeleit-Dahm KA. Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune-inflammatory responses in diabetic Apoe(-/-) mice. Diabetologia. 57: 633-42. PMID 24292634 DOI: 10.1007/S00125-013-3118-3  0.317
2014 Weber MA, Schiffrin EL, White WB, Mann S, Lindholm LH, Kenerson JG, Flack JM, Carter BL, Materson BJ, Ram CV, Cohen DL, Cadet JC, Jean-Charles RR, Taler S, Kountz D, ... ... Touyz RM, et al. Clinical practice guidelines for the management of hypertension in the community a statement by the American Society of Hypertension and the International Society of Hypertension. Journal of Hypertension. 32: 3-15. PMID 24270181 DOI: 10.1097/Hjh.0000000000000065  0.31
2014 Holterman CE, Thibodeau JF, Towaij C, Gutsol A, Montezano AC, Parks RJ, Cooper ME, Touyz RM, Kennedy CR. Nephropathy and elevated BP in mice with podocyte-specific NADPH oxidase 5 expression. Journal of the American Society of Nephrology : Jasn. 25: 784-97. PMID 24262797 DOI: 10.1681/Asn.2013040371  0.339
2014 Wilkinson-Berka JL, Deliyanti D, Rana I, Miller AG, Agrotis A, Armani R, Szyndralewiez C, Wingler K, Touyz RM, Cooper ME, Jandeleit-Dahm KA, Schmidt HH. NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy. Antioxidants & Redox Signaling. 20: 2726-40. PMID 24053718 DOI: 10.1089/Ars.2013.5357  0.34
2014 Montezano AC, Touyz RM. Reactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical research. Antioxidants & Redox Signaling. 20: 164-82. PMID 23600794 DOI: 10.1089/Ars.2013.5302  0.356
2013 White M, Cantin B, Haddad H, Kobashigawa JA, Ross H, Carrier M, Pflugfelder PW, Isaac D, Cecere R, Whittom L, Ali IS, Wang SH, He Y, Groulx A, Touyz RM. Cardiac signaling molecules and plasma biomarkers after cardiac transplantation: impact of tacrolimus versus cyclosporine. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 32: 1222-32. PMID 24263023 DOI: 10.1016/J.Healun.2013.09.010  0.305
2013 Thibodeau JF, Nasrallah R, Carter A, He Y, Touyz R, Hébert RL, Kennedy CR. PTGER1 deletion attenuates renal injury in diabetic mouse models. The American Journal of Pathology. 183: 1789-802. PMID 24113456 DOI: 10.1016/J.Ajpath.2013.08.022  0.301
2013 Sedeek M, Nasrallah R, Touyz RM, Hébert RL. NADPH oxidases, reactive oxygen species, and the kidney: friend and foe. Journal of the American Society of Nephrology : Jasn. 24: 1512-8. PMID 23970124 DOI: 10.1681/Asn.2012111112  0.33
2013 Yogi A, Callera GE, O'Connor S, Antunes TT, Valinsky W, Miquel P, Montezano AC, Perraud AL, Schmitz C, Shrier A, Touyz RM. Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain. Cellular Signalling. 25: 2163-75. PMID 23838006 DOI: 10.1016/J.Cellsig.2013.07.002  0.3
2013 Montezano AC, Touyz RM. Mechanosensitive regulation of cortactin by p47phox: a new paradigm in cytoskeletal remodeling. Circulation Research. 112: 1522-5. PMID 23743221 DOI: 10.1161/Circresaha.113.301495  0.367
2013 Gray SP, Di Marco E, Okabe J, Szyndralewiez C, Heitz F, Montezano AC, de Haan JB, Koulis C, El-Osta A, Andrews KL, Chin-Dusting JP, Touyz RM, Wingler K, Cooper ME, Schmidt HH, et al. NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. Circulation. 127: 1888-902. PMID 23564668 DOI: 10.1161/Circulationaha.112.132159  0.355
2013 Touyz RM. Combination antihypertensive treatment with aliskiren and blockers of the Renin-Angiotensin system-reassurance but with a note of caution. The Canadian Journal of Cardiology. 29: 521-3. PMID 23541659 DOI: 10.1016/J.Cjca.2013.02.020  0.371
2013 Chalmers J, Arima H, Harrap S, Touyz RM, Park JB. Global survey of current practice in management of hypertension as reported by societies affiliated with the International Society of Hypertension. Journal of Hypertension. 31: 1043-8. PMID 23429664 DOI: 10.1097/Hjh.0B013E32835F7Eef  0.313
2013 Der Sarkissian S, Tea BS, Touyz RM, Deblois D, Hale TM. Role of angiotensin II type 2 receptor during regression of cardiac hypertrophy in spontaneously hypertensive rats Journal of the American Society of Hypertension. 7: 118-127. PMID 23414835 DOI: 10.1016/J.Jash.2013.01.002  0.334
2013 Burger D, Schock S, Thompson CS, Montezano AC, Hakim AM, Touyz RM. Microparticles: biomarkers and beyond. Clinical Science (London, England : 1979). 124: 423-41. PMID 23249271 DOI: 10.1042/Cs20120309  0.3
2013 Sedeek M, Gutsol A, Montezano AC, Burger D, Nguyen Dinh Cat A, Kennedy CR, Burns KD, Cooper ME, Jandeleit-Dahm K, Page P, Szyndralewiez C, Heitz F, Hebert RL, Touyz RM. Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes. Clinical Science (London, England : 1979). 124: 191-202. PMID 22920224 DOI: 10.1042/Cs20120330  0.335
2013 Nguyen Dinh Cat A, Montezano AC, Burger D, Touyz RM. Angiotensin II, NADPH oxidase, and redox signaling in the vasculature. Antioxidants & Redox Signaling. 19: 1110-20. PMID 22530599 DOI: 10.1089/Ars.2012.4641  0.376
2012 Burger D, Kwart DG, Montezano AC, Read NC, Kennedy CR, Thompson CS, Touyz RM. Microparticles induce cell cycle arrest through redox-sensitive processes in endothelial cells: implications in vascular senescence. Journal of the American Heart Association. 1: e001842. PMID 23130145 DOI: 10.1161/Jaha.112.001842  0.365
2012 Yogi A, Callera GE, Mecawi AS, Batalhão ME, Carnio EC, Antunes-Rodrigues J, Queiroz RH, Touyz RM, Tirapelli CR. Acute ethanol intake induces superoxide anion generation and mitogen-activated protein kinase phosphorylation in rat aorta: a role for angiotensin type 1 receptor. Toxicology and Applied Pharmacology. 264: 470-8. PMID 22982071 DOI: 10.1016/J.Taap.2012.08.029  0.357
2012 Montezano AC, Touyz RM. Oxidative stress, Noxs, and hypertension: experimental evidence and clinical controversies. Annals of Medicine. 44: S2-16. PMID 22713144 DOI: 10.3109/07853890.2011.653393  0.38
2012 Daskalopoulou SS, Khan NA, Quinn RR, Ruzicka M, McKay DW, Hackam DG, Rabkin SW, Rabi DM, Gilbert RE, Padwal RS, Dawes M, Touyz RM, Campbell TS, Cloutier L, Grover S, et al. The 2012 Canadian hypertension education program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy. The Canadian Journal of Cardiology. 28: 270-87. PMID 22595447 DOI: 10.1016/J.Cjca.2012.02.018  0.361
2012 Chignalia AZ, Schuldt EZ, Camargo LL, Montezano AC, Callera GE, Laurindo FR, Lopes LR, Avellar MC, Carvalho MH, Fortes ZB, Touyz RM, Tostes RC. Testosterone induces vascular smooth muscle cell migration by NADPH oxidase and c-Src-dependent pathways. Hypertension. 59: 1263-71. PMID 22566500 DOI: 10.1161/Hypertensionaha.111.180620  0.4
2012 Touyz RM, Montezano AC. Vascular Nox4: a multifarious NADPH oxidase. Circulation Research. 110: 1159-61. PMID 22539753 DOI: 10.1161/Circresaha.112.269068  0.39
2012 Briones AM, Nguyen Dinh Cat A, Callera GE, Yogi A, Burger D, He Y, Corrêa JW, Gagnon AM, Gomez-Sanchez CE, Gomez-Sanchez EP, Sorisky A, Ooi TC, Ruzicka M, Burns KD, Touyz RM. Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-associated obesity and vascular dysfunction. Hypertension. 59: 1069-78. PMID 22493070 DOI: 10.1161/Hypertensionaha.111.190223  0.399
2012 Montezano AC, Touyz RM. Molecular mechanisms of hypertension--reactive oxygen species and antioxidants: a basic science update for the clinician. The Canadian Journal of Cardiology. 28: 288-95. PMID 22445098 DOI: 10.1016/J.Cjca.2012.01.017  0.436
2012 Paravicini TM, Montezano AC, Yusuf H, Touyz RM. Activation of vascular p38MAPK by mechanical stretch is independent of c-Src and NADPH oxidase: influence of hypertension and angiotensin II. Journal of the American Society of Hypertension : Jash. 6: 169-78. PMID 22341198 DOI: 10.1016/J.Jash.2012.01.002  0.446
2012 Burger D, Touyz RM. Cellular biomarkers of endothelial health: microparticles, endothelial progenitor cells, and circulating endothelial cells. Journal of the American Society of Hypertension : Jash. 6: 85-99. PMID 22321962 DOI: 10.1016/J.Jash.2011.11.003  0.367
2012 Burger D, Veerabhadrappa P, Charchar F, Tomaszewski M, Harrap S, Carlberg B, Touyz RM. Report of the first International Society of Hypertension (ISH) Trainee/New Investigator Symposium: A Global Hypertension Initiative. Journal of Hypertension. 30: 631-2. PMID 22278140 DOI: 10.1097/Hjh.0B013E32834F8267  0.343
2012 Touyz RM. New insights into mechanisms of hypertension. Current Opinion in Nephrology and Hypertension. 21: 119-21. PMID 22257800 DOI: 10.1097/Mnh.0B013E328350A50F  0.332
2012 White M, Montezano AC, Touyz RM. Angiotensin II signalling and calcineurin in cardiac fibroblasts: differential effects of calcineurin inhibitors FK506 and cyclosporine A. Therapeutic Advances in Cardiovascular Disease. 6: 5-14. PMID 22184128 DOI: 10.1177/1753944711432901  0.343
2012 Rocha JT, Hipólito UV, Callera GE, Yogi A, Neto Filho Mdos A, Bendhack LM, Touyz RM, Tirapelli CR. Ethanol induces vascular relaxation via redox-sensitive and nitric oxide-dependent pathways. Vascular Pharmacology. 56: 74-83. PMID 22155162 DOI: 10.1016/J.Vph.2011.11.006  0.303
2012 Veerabhadrappa P, Burger D, Charchar F, Tomaszewski M, Carlberg B, Harrap S, Touyz RM. Council for [corrected] High Blood Pressure Research/InterAmerican Society of Hypertension/International Society of Hypertension: [corrected] first New Investigators Symposium at the High Blood Pressure Research 2011 Scientific Sessions. Hypertension. 59: 382-3. PMID 22083164 DOI: 10.1161/Hypertensionaha.111.185421  0.333
2012 Montezano AC, Touyz RM. Reactive oxygen species and endothelial function--role of nitric oxide synthase uncoupling and Nox family nicotinamide adenine dinucleotide phosphate oxidases. Basic & Clinical Pharmacology & Toxicology. 110: 87-94. PMID 21883939 DOI: 10.1111/J.1742-7843.2011.00785.X  0.371
2012 Touyz RM, Savoia C, He Y, Endemann D, Pu Q, Ko EA, Deciuceis C, Montezano A, Schiffrin EL. Increased inflammatory biomarkers in hypertensive type 2 diabetic patients: improvement after angiotensin II type 1 receptor blockade. Journal of the American Society of Hypertension : Jash. 1: 189-99. PMID 20409851 DOI: 10.1016/J.Jash.2007.01.009  0.344
2012 Montezano AC, Amiri F, Tostes RC, Touyz RM, Schiffrin EL. Inhibitory effects of PPAR-gamma on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats. Journal of the American Society of Hypertension : Jash. 1: 150-60. PMID 20409845 DOI: 10.1016/J.Jash.2007.01.005  0.363
2012 Kurtz TW, Cosentino F, Raij L, Wei C, Gavras H, Germanò G, Sanguigni V, Pignatelli P, Caccese D, Lenti L, Ragazzo M, Lauro R, Violi F, Touyz RM, Mezzetti A, et al. The Renin-Angiotensin System in Cardiovascular and Renal Disease Annual Review of Physiology. 11: 75-81. DOI: 10.2165/00151642-200411020-00005  0.306
2012 Burger D, Kwart D, Montezano AC, Thompson CS, Touyz RM. 18 Microparticles Induce Endothelial Cell Senescence And Cell Cycle Arrest Through Redox-Sensitive Processes: Implications In Vascular Aging Journal of Hypertension. 30. DOI: 10.1097/01.Hjh.0000419844.81754.1B  0.339
2012 Touyz RM, Burger D. 14 Emerging Vascular Targets: Microparticles A New Player In Vascular Signaling Journal of Hypertension. 30. DOI: 10.1097/01.Hjh.0000419840.89378.06  0.345
2012 Touyz RM, Schiffrin EL. Chapter 99 – Arterial Hypertension Musclefundamental Biology and Mechanisms of Disease. 1311-1319. DOI: 10.1016/B978-0-12-381510-1.00099-5  0.333
2011 Chung Y, Abou-Nassar KE, Li Y, Filion L, Watpool I, McArdle T, McIntyre L, Ramsay T, Cheesman J, Touyz R, Burns KD, Allan DS. Vascular progenitor recruitment in critically ill patients with acute kidney injury. Clinical and Investigative Medicine. MéDecine Clinique Et Experimentale. 34: E304. PMID 21968273 DOI: 10.25011/Cim.V34I5.15674  0.342
2011 Nguyen Dinh Cat A, Touyz RM. A new look at the renin-angiotensin system--focusing on the vascular system. Peptides. 32: 2141-50. PMID 21945916 DOI: 10.1016/J.Peptides.2011.09.010  0.364
2011 Rabi DM, Daskalopoulou SS, Padwal RS, Khan NA, Grover SA, Hackam DG, Myers MG, McKay DW, Quinn RR, Hemmelgarn BR, Cloutier L, Bolli P, Hill MD, Wilson T, Penner B, ... ... Touyz RM, et al. The 2011 Canadian Hypertension Education Program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy. The Canadian Journal of Cardiology. 27: 415-433.e1-2. PMID 21801975 DOI: 10.1016/J.Cjca.2011.03.015  0.381
2011 Nguyen Dinh Cat A, Briones AM, Callera GE, Yogi A, He Y, Montezano AC, Touyz RM. Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors. Hypertension. 58: 479-88. PMID 21788604 DOI: 10.1161/Hypertensionaha.110.168872  0.367
2011 Al Ghouleh I, Khoo NKH, Knaus UG, Griendling KK, Touyz RM, Thannickal VJ, Barchowsky A, Nauseef WM, Kelley EE, Bauer PM, Darley-Usmar V, Shiva S, Cifuentes-Pagano E, Freeman BA, Gladwin MT, et al. Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling Free Radical Biology and Medicine. 51: 1271-1288. PMID 21722728 DOI: 10.1016/J.Freeradbiomed.2011.06.011  0.314
2011 Yogi A, Callera GE, O'Connor SE, He Y, Correa JW, Tostes RC, Mazur A, Touyz RM. Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia. Journal of Hypertension. 29: 1400-10. PMID 21602712 DOI: 10.1097/Hjh.0B013E32834786D6  0.364
2011 Burger D, Montezano AC, Nishigaki N, He Y, Carter A, Touyz RM. Endothelial microparticle formation by angiotensin II is mediated via Ang II receptor type I/NADPH oxidase/ Rho kinase pathways targeted to lipid rafts. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 1898-907. PMID 21597004 DOI: 10.1161/Atvbaha.110.222703  0.412
2011 Callera GE, Yogi A, Briones AM, Montezano AC, He Y, Tostes RC, Schiffrin EL, Touyz RM. Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: role of PDGFR. Cardiovascular Research. 91: 720-31. PMID 21576132 DOI: 10.1093/Cvr/Cvr131  0.352
2011 Savoia C, Burger D, Nishigaki N, Montezano A, Touyz RM. Angiotensin II and the vascular phenotype in hypertension. Expert Reviews in Molecular Medicine. 13. PMID 21450123 DOI: 10.1017/S1462399411001815  0.463
2011 Touyz RM, Briones AM, Sedeek M, Burger D, Montezano AC. NOX isoforms and reactive oxygen species in vascular health. Molecular Interventions. 11: 27-35. PMID 21441119 DOI: 10.1124/Mi.11.1.5  0.376
2011 Briones AM, Tabet F, Callera GE, Montezano AC, Yogi A, He Y, Quinn MT, Salaices M, Touyz RM. Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR. Journal of the American Society of Hypertension : Jash. 5: 137-53. PMID 21419746 DOI: 10.1016/J.Jash.2011.02.001  0.399
2011 Yogi A, Callera GE, Aranha AB, Antunes TT, Graham D, McBride M, Dominiczak A, Touyz RM. Sphingosine-1-Phosphate-Induced Inflammation Involves Receptor Tyrosine Kinase Transactivation in Vascular Cells Upregulation in Hypertension Hypertension. 57: 809-818. PMID 21383307 DOI: 10.1161/Hypertensionaha.110.162719  0.385
2011 Touyz RM. Advancement in hypertension pathogenesis: some new concepts. Current Opinion in Nephrology and Hypertension. 20: 105-106. PMID 21307673 DOI: 10.1097/Mnh.0B013E328343F526  0.324
2011 Cat AND, Touyz RM. Cell Signaling of Angiotensin II on Vascular Tone: Novel Mechanisms Current Hypertension Reports. 13: 122-128. PMID 21274755 DOI: 10.1007/S11906-011-0187-X  0.441
2011 Meziri F, Binda D, Touati S, Pellegrin M, Berthelot A, Touyz RM, Laurant P. Exercise aggravates cardiovascular risks and mortality in rats with disrupted nitric oxide pathway and treated with recombinant human erythropoietin European Journal of Applied Physiology. 111: 1929-1938. PMID 21249387 DOI: 10.1007/S00421-011-1829-Z  0.338
2011 Yogi A, Callera GE, Antunes TT, Tostes RC, Touyz RM. Transient receptor potential melastatin 7 (TRPM7) cation channels, magnesium and the vascular system in hypertension Circulation. 75: 237-245. PMID 21150127 DOI: 10.1253/Circj.Cj-10-1021  0.433
2011 Cascino T, Csanyi G, Ghouleh IA, Montezano AC, Touyz RM, Haurani MJ, Pagano PJ. Adventitia-derived hydrogen peroxide impairs relaxation of the rat carotid artery via smooth muscle cell p38 mitogen-activated protein kinase. Antioxidants & Redox Signaling. 15: 1507-1515. PMID 21126185 DOI: 10.1089/Ars.2010.3631  0.419
2011 Montezano AC, Burger D, Ceravolo GS, Yusuf H, Montero M, Touyz RM. Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5. Clinical Science. 120: 131-141. PMID 21039341 DOI: 10.1042/Cs20100384  0.333
2011 Touyz RM, Briones AM. Reactive oxygen species and vascular biology: implications in human hypertension. Hypertension Research : Official Journal of the Japanese Society of Hypertension. 34: 5-14. PMID 20981034 DOI: 10.1038/Hr.2010.201  0.44
2011 Touyz RM. 2010 Annual Fall Conference and Scientific Session of the American Heart Association Council for High Blood Pressure Research in Association With the Council on the Kidney in Cardiovascular Disease Hypertension. 57: 521-525. DOI: 10.1161/Hypertensionaha.111.169516  0.33
2010 Yogi A, Callera GE, Antunes TT, Tostes RC, Touyz RM. Vascular biology of magnesium and its transporters in hypertension Magnesium Research. 23: 207-215. PMID 21199786 DOI: 10.1684/Mrh.2010.0222  0.405
2010 Montezano AC, Zimmerman D, Yusuf H, Burger D, Chignalia AZ, Wadhera V, Leeuwen FNv, Touyz RM. Vascular Smooth Muscle Cell Differentiation to an Osteogenic Phenotype Involves TRPM7 Modulation by Magnesium Hypertension. 56: 453-462. PMID 20696983 DOI: 10.1161/Hypertensionaha.110.152058  0.371
2010 Hackam DG, Khan NA, Hemmelgarn BR, Rabkin SW, Touyz RM, Campbell NR, Padwal R, Campbell TS, Lindsay MP, Hill MD, Quinn RR, Mahon JL, Herman RJ, Schiffrin EL, Ruzicka M, et al. The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy. The Canadian Journal of Cardiology. 26: 249-58. PMID 20485689 DOI: 10.1016/S0828-282X(10)70379-2  0.317
2010 Briones AM, Touyz RM. Oxidative stress and hypertension: current concepts. Current Hypertension Reports. 12: 135-42. PMID 20424957 DOI: 10.1007/S11906-010-0100-Z  0.427
2010 Montezano AC, Burger D, Paravicini TM, Chignalia AZ, Yusuf H, Almasri M, He Y, Callera GE, He G, Krause KH, Lambeth D, Quinn MT, Touyz RM. Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium/calmodulin-dependent, rac-1-independent pathways in human endothelial cells. Circulation Research. 106: 1363-73. PMID 20339118 DOI: 10.1161/Circresaha.109.216036  0.388
2010 Burger D, Nishigaki N, Touyz RM. New insights into molecular mechanisms of hypertension. Current Opinion in Nephrology and Hypertension. 19: 160-162. PMID 20098323 DOI: 10.1097/Mnh.0B013E32833680C4  0.311
2010 Yogi A, O'Connor SE, Callera GE, Tostes RC, Touyz RM. Receptor and nonreceptor tyrosine kinases in vascular biology of hypertension Current Opinion in Nephrology and Hypertension. 19: 169-176. PMID 20051848 DOI: 10.1097/Mnh.0B013E3283361C24  0.402
2010 Toto R, Touyz R. Current Opinion in Nephrology and Hypertension: Editorial introductions Current Opinion in Nephrology and Hypertension. 19. DOI: 10.1097/Mnh.0B013E3283369Ed2  0.327
2009 Javeshghani D, Schiffrin EL, Sairam MR, Touyz RM. Potentiation of vascular oxidative stress and nitric oxide-mediated endothelial dysfunction by high-fat diet in a mouse model of estrogen deficiency and hyperandrogenemia. Journal of the American Society of Hypertension : Jash. 3: 295-305. PMID 20409973 DOI: 10.1016/J.Jash.2009.07.002  0.368
2009 Briones AM, Touyz RM. Moderate exercise decreases inflammation and oxidative stress in hypertension: but what are the mechanisms? Hypertension (Dallas, Tex. : 1979). 54: 1206-8. PMID 19841287 DOI: 10.1161/Hypertensionaha.109.136622  0.353
2009 Xu S, He Y, Vokurkova M, Touyz RM. Endothelial Cells Negatively Modulate Reactive Oxygen Species Generation in Vascular Smooth Muscle Cells: Role of Thioredoxin Hypertension. 54: 427-433. PMID 19564543 DOI: 10.1161/Hypertensionaha.109.133983  0.351
2009 Sedeek M, Hébert RL, Kennedy CR, Burns KD, Touyz RM. Molecular mechanisms of hypertension: role of Nox family NADPH oxidases. Current Opinion in Nephrology and Hypertension. 18: 122-7. PMID 19430333 DOI: 10.1097/Mnh.0B013E32832923C3  0.412
2009 Khan NA, Hemmelgarn B, Herman RJ, Bell CM, Mahon JL, Leiter LA, Rabkin SW, Hill MD, Padwal R, Touyz RM, Larochelle P, Feldman RD, Schiffrin EL, Campbell NR, Moe G, et al. The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2--therapy. The Canadian Journal of Cardiology. 25: 287-98. PMID 19417859 DOI: 10.1016/S0828-282X(09)70492-1  0.305
2009 White M, Touyz R, Tessier Y, Van Le V, Ross H, Sirois MG. Persistent elevation of VEGF and prostacyclin following poor cardiopulmonary adaptation to high altitude. Wilderness & Environmental Medicine. 20: 97-8. PMID 19364178 DOI: 10.1580/08-Weme-Le-248.1  0.308
2009 Callera GE, He Y, Yogi A, Montezano AC, Paravicini T, Yao G, Touyz RM. Regulation of the novel Mg2+ transporter transient receptor potential melastatin 7 (TRPM7) cation channel by bradykinin in vascular smooth muscle cells. Journal of Hypertension. 27: 155-166. PMID 19145781 DOI: 10.1097/Hjh.0B013E3283190582  0.353
2009 Gava E, Samad-Zadeh A, Zimpelmann J, Bahramifarid N, Kitten GT, Santos RA, Touyz RM, Burns KD. Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 24: 1766-73. PMID 19144997 DOI: 10.1093/Ndt/Gfn736  0.355
2009 Paravicini TM, Yogi A, Mazur A, Touyz RM. Dysregulation of Vascular TRPM7 and Annexin-1 Is Associated With Endothelial Dysfunction in Inherited Hypomagnesemia Hypertension. 53: 423-429. PMID 19103997 DOI: 10.1161/Hypertensionaha.108.124651  0.421
2009 Yogi A, Callera GE, Tostes R, Touyz RM. Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells. American Journal of Physiology-Regulatory Integrative and Comparative Physiology. 296. PMID 18799634 DOI: 10.1152/Ajpregu.90602.2008  0.344
2008 Park YM, Lim BH, Touyz RM, Park JB. Expression of NAD(P)H oxidase subunits and their contribution to cardiovascular damage in aldosterone/salt-induced hypertensive rat. Journal of Korean Medical Science. 23: 1039-45. PMID 19119450 DOI: 10.3346/Jkms.2008.23.6.1039  0.354
2008 Touyz RM, Callera GE. A New Look at the Eye Aldosterone and Mineralocorticoid Receptors As Novel Targets in Retinal Vasculopathy Circulation Research. 104: 9-11. PMID 19118282 DOI: 10.1161/Circresaha.108.191288  0.376
2008 Touyz RM, Montezano AC. Vascular smooth muscle cells sense calcium: a new paradigm in vascular calcification. Cardiovascular Research. 81: 237-239. PMID 19088081 DOI: 10.1093/Cvr/Cvn345  0.399
2008 Montezano AC, Touyz RM. Networking Between Systemic Angiotensin II and Cardiac Mineralocorticoid Receptors Hypertension. 52: 1016-1018. PMID 18981322 DOI: 10.1161/Hypertensionaha.108.121269  0.381
2008 Yzydorczyk C, Comte B, Cambonie G, Lavoie JC, Germain N, Ting Shun Y, Wolff J, Deschepper C, Touyz RM, Lelièvre-Pegorier M, Nuyt AM. Neonatal oxygen exposure in rats leads to cardiovascular and renal alterations in adulthood. Hypertension. 52: 889-95. PMID 18852387 DOI: 10.1161/Hypertensionaha.108.116251  0.411
2008 Mercure C, Yogi A, Callera GE, Aranha AB, Bader M, Ferreira AJ, Santos RA, Walther T, Touyz RM, Reudelhuber TL. Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart. Circulation Research. 103: 1319-26. PMID 18845809 DOI: 10.1161/Circresaha.108.184911  0.368
2008 Ebrahimian T, Sairam MR, Schiffrin EL, Touyz RM. Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause. American Journal of Physiology. Heart and Circulatory Physiology. 295: H1481-8. PMID 18676690 DOI: 10.1152/Ajpheart.00163.2008  0.398
2008 Tabet F, Schiffrin EL, Callera GE, He Y, Yao G, Ostman A, Kappert K, Tonks NK, Touyz RM. Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR. Circulation Research. 103: 149-58. PMID 18566342 DOI: 10.1161/Circresaha.108.178608  0.405
2008 Khan NA, Hemmelgarn B, Herman RJ, Rabkin SW, McAlister FA, Bell CM, Touyz RM, Padwal R, Leiter LA, Mahon JL, Hill MD, Larochelle P, Feldman RD, Schiffrin EL, Campbell NR, et al. The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy. The Canadian Journal of Cardiology. 24: 465-75. PMID 18548143 DOI: 10.1016/S0828-282X(08)70620-2  0.305
2008 Padwal RS, Hemmelgarn BR, Khan NA, Grover S, McAlister FA, McKay DW, Wilson T, Penner B, Burgess E, Bolli P, Hill MD, Mahon J, Myers MG, Abbott C, Schiffrin EL, ... ... Touyz RM, et al. The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1 - blood pressure measurement, diagnosis and assessment of risk. The Canadian Journal of Cardiology. 24: 455-63. PMID 18548142 DOI: 10.1016/S0828-282X(08)70619-6  0.341
2008 Viel EC, Benkirane K, Javeshghani D, Touyz RM, Schiffrin EL. Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats. American Journal of Physiology. Heart and Circulatory Physiology. 295: H281-8. PMID 18487445 DOI: 10.1152/Ajpheart.00304.2008  0.357
2008 Montezano AC, Callera GE, Yogi A, He Y, Tostes RC, He G, Schiffrin EL, Touyz RM. Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1511-8. PMID 18467645 DOI: 10.1161/Atvbaha.108.168021  0.412
2008 Ebrahimian T, Touyz RM. Thioredoxin in vascular biology: role in hypertension. Antioxidants & Redox Signaling. 10: 1127-1136. PMID 18315495 DOI: 10.1089/Ars.2007.1985  0.389
2008 Sontia B, Montezano ACI, Paravicini T, Tabet F, Touyz RM. Downregulation of Renal TRPM7 and Increased Inflammation and Fibrosis in Aldosterone-Infused Mice Effects of Magnesium Hypertension. 51: 915-921. PMID 18268139 DOI: 10.1161/Hypertensionaha.107.100339  0.326
2008 Sontia B, Mooney J, Gaudet L, Touyz RM. Pseudohyperaldosteronism, liquorice, and hypertension. Journal of Clinical Hypertension. 10: 153-157. PMID 18256580 DOI: 10.1111/J.1751-7176.2008.07470.X  0.37
2008 Paravicini TM, Touyz RM. NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes Care. 31: 170-180. PMID 18227481 DOI: 10.2337/Dc08-S247  0.414
2008 Yogi A, Mercure C, Touyz J, Callera GE, Montezano AC, Aranha AB, Tostes RC, Reudelhuber T, Touyz RM. Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in angiotensin II-dependent chronic hypertension. Hypertension (Dallas, Tex. : 1979). 51: 500-6. PMID 18195161 DOI: 10.1161/Hypertensionaha.107.103192  0.399
2008 Savoia C, Touyz RM, Amiri F, Schiffrin EL. Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients. Hypertension (Dallas, Tex. : 1979). 51: 432-9. PMID 18195160 DOI: 10.1161/Hypertensionaha.107.103267  0.378
2008 Touyz RM. Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension American Journal of Physiology-Heart and Circulatory Physiology. 294. PMID 18192217 DOI: 10.1152/Ajpheart.00903.2007  0.431
2008 Touyz RM. Apocynin, NADPH oxidase, and vascular cells: a complex matter. Hypertension. 51: 172-174. PMID 18086948 DOI: 10.1161/Hypertensionaha.107.103200  0.321
2008 Tostes RC, Fortes ZB, Callera GE, Montezano AC, Touyz RM, Webb RC, Carvalho MH. Endothelin, sex and hypertension. Clinical Science (London, England : 1979). 114: 85-97. PMID 18062774 DOI: 10.1042/Cs20070169  0.302
2008 Touyz RM. Targeting the ailing endothelium – current concepts and future prospects Canadian Journal of Cardiology. 24. DOI: 10.1016/S0828-282X(08)71037-7  0.42
2007 Javeshghani D, Sairam MR, Schiffrin EL, Touyz RM. Increased blood pressure, vascular inflammation, and endothelial dysfunction in androgen-deficient follitropin receptor knockout male mice. Journal of the American Society of Hypertension : Jash. 1: 353-61. PMID 20409866 DOI: 10.1016/J.Jash.2007.06.003  0.399
2007 Vokurkova M, Xu S, Touyz RM. Reactive oxygen species, cell growth, cell cycle progression and vascular remodeling in hypertension Future Cardiology. 3: 53-63. PMID 19804207 DOI: 10.2217/14796678.3.1.53  0.418
2007 Sontia B, Touyz RM. Magnesium transport in hypertension Pathophysiology. 14: 205-211. PMID 18029156 DOI: 10.1016/J.Pathophys.2007.09.005  0.386
2007 Sampaio WO, Henrique de Castro C, Santos RA, Schiffrin EL, Touyz RM. Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells. Hypertension (Dallas, Tex. : 1979). 50: 1093-8. PMID 17984366 DOI: 10.1161/Hypertensionaha.106.084848  0.39
2007 Touyz RM. Vascular Remodeling, Retinal Arteries, and Hypertension Hypertension. 50: 603-604. PMID 17698718 DOI: 10.1161/Hypertensionaha.107.095638  0.413
2007 da Costa Gonçalves AC, Leite R, Fraga-Silva RA, Pinheiro SV, Reis AB, Reis FM, Touyz RM, Webb RC, Alenina N, Bader M, Santos RA. Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function. American Journal of Physiology. Heart and Circulatory Physiology. 293: H2588-96. PMID 17616753 DOI: 10.1152/Ajpheart.00173.2007  0.373
2007 Yogi A, Callera GE, Montezano AC, Aranha AB, Tostes RC, Schiffrin EL, Touyz RM. Endothelin-1, but not Ang II, activates MAP kinases through c-Src independent Ras-Raf dependent pathways in vascular smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1960-7. PMID 17569879 DOI: 10.1161/Atvbaha.107.146746  0.39
2007 Ebrahimian T, He Y, Schiffrin EL, Touyz RM. Differential regulation of thioredoxin and NAD(P)H oxidase by angiotensin II in male and female mice. Journal of Hypertension. 25: 1263-71. PMID 17563540 DOI: 10.1097/Hjh.0B013E3280Acac60  0.329
2007 Tobe SW, Touyz RM, Campbell NRC. The Canadian Hypertension Education Program – a unique Canadian knowledge translation program Canadian Journal of Cardiology. 23: 551-555. PMID 17534461 DOI: 10.1016/S0828-282X(07)70799-7  0.324
2007 Khan NA, Hemmelgarn B, Padwal R, Larochelle P, Mahon JL, Lewanczuk RZ, McAlister FA, Rabkin SW, Hill MD, Feldman RD, Schiffrin EL, Campbell NR, Logan AG, Arnold M, Moe G, ... ... Touyz RM, et al. The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy. The Canadian Journal of Cardiology. 23: 539-50. PMID 17534460 DOI: 10.1016/S0828-282X(07)70798-5  0.305
2007 White M, Lepage S, Lavoie J, De Denus S, Leblanc MH, Gossard D, Whittom L, Racine N, Ducharme A, Dabouz F, Rouleau JL, Touyz R. Effects of Combined Candesartan and ACE Inhibitors on BNP, Markers of Inflammation and Oxidative Stress, and Glucose Regulation in Patients With Symptomatic Heart Failure Journal of Cardiac Failure. 13: 86-94. PMID 17395047 DOI: 10.1016/J.Cardfail.2006.10.013  0.318
2007 De Ciuceis C, Amiri F, Iglarz M, Cohn JS, Touyz RM, Schiffrin EL. Synergistic vascular protective effects of combined low doses of PPARalpha and PPARgamma activators in angiotensin II-induced hypertension in rats. British Journal of Pharmacology. 151: 45-53. PMID 17351653 DOI: 10.1038/Sj.Bjp.0707215  0.369
2007 Callera GE, Montezano AC, Yogi A, Tostes RC, Touyz RM. Vascular signaling through cholesterol-rich domains: implications in hypertension. Current Opinion in Nephrology and Hypertension. 16: 90-104. PMID 17293683 DOI: 10.1097/Mnh.0B013E328040Bfbd  0.383
2007 Zargham R, Touyz RM, Thibault G. α8 Integrin overexpression in de-differentiated vascular smooth muscle cells attenuates migratory activity and restores the characteristics of the differentiated phenotype Atherosclerosis. 195: 303-312. PMID 17275006 DOI: 10.1016/J.Atherosclerosis.2007.01.005  0.334
2007 Touyz RM. Regulation of Endothelial Nitric Oxide Synthase by Thrombin Hypertension. 49: 429-431. PMID 17210837 DOI: 10.1161/01.Hyp.0000255955.75119.1A  0.419
2007 Sontia B, Touyz RM. Role of magnesium in hypertension Archives of Biochemistry and Biophysics. 458: 33-39. PMID 16762312 DOI: 10.1016/J.Abb.2006.05.005  0.409
2007 Savoia C, Lemarie CA, Touyz RM, Rozen R, Volpe M, Schiffrin EL. Peroxisome Proliferator-Activated Receptors Activator, Rosiglitazone, Improves Vascular Structure and Reduces Lipid Deposition in Atherosclerotic Mthfr Knock-Out Mice High Blood Pressure & Cardiovascular Prevention. 14: 145-196. DOI: 10.2165/00151642-200714030-00180  0.317
2007 Savoia C, Ebrahimian T, He Y, Gratton JP, Schiffrin EL, Touyz RM. Erratum: Angiotensin II/AT2 receptor-induced vasodilation in SHRSP involves nitric oxide and cGMP-dependent protein kinase (Journal of Hypertension (2006) 24 (2417-2422)) Journal of Hypertension. 25. DOI: 10.1097/01.Hjh.0000259930.90881.19  0.407
2006 Savoia C, Touyz RM, Volpe M, Schiffrin EL. Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients. Hypertension (Dallas, Tex. : 1979). 49: 341-6. PMID 17159079 DOI: 10.1161/01.Hyp.0000253968.95136.B8  0.395
2006 Ko EA, Amiri F, Pandey NR, Javeshghani D, Leibovitz E, Touyz RM, Schiffrin EL. Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: evidence from m-CSF-deficient mice. American Journal of Physiology. Heart and Circulatory Physiology. 292: H1789-95. PMID 17142347 DOI: 10.1152/Ajpheart.01118.2006  0.379
2006 Sampaio WO, Souza dos Santos RA, Faria-Silva R, da Mata Machado LT, Schiffrin EL, Touyz RM. Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways. Hypertension (Dallas, Tex. : 1979). 49: 185-92. PMID 17116756 DOI: 10.1161/01.Hyp.0000251865.35728.2F  0.409
2006 Savoia C, Ebrahimian T, He Y, Gratton JP, Schiffrin EL, Touyz RM. Angiotensin II/AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric oxide and cGMP-dependent protein kinase. Journal of Hypertension. 24: 2417-22. PMID 17082724 DOI: 10.1097/01.Hjh.0000251902.85675.7E  0.406
2006 Xu S, Touyz RM. Reactive oxygen species and vascular remodelling in hypertension: Still alive Canadian Journal of Cardiology. 22: 947-951. PMID 16971980 DOI: 10.1016/S0828-282X(06)70314-2  0.426
2006 Javeshghani D, Sairam MR, Neves MF, Schiffrin EL, Touyz RM. Angiotensin II induces vascular dysfunction without exacerbating blood pressure elevation in a mouse model of menopause-associated hypertension. Journal of Hypertension. 24: 1365-73. PMID 16794486 DOI: 10.1097/01.Hjh.0000234117.25401.F8  0.417
2006 Savoia C, Touyz RM, Endemann DH, Pu Q, Ko EA, De Ciuceis C, Schiffrin EL. Angiotensin receptor blocker added to previous antihypertensive agents on arteries of diabetic hypertensive patients. Hypertension (Dallas, Tex. : 1979). 48: 271-7. PMID 16785331 DOI: 10.1161/01.Hyp.0000230234.84356.36  0.373
2006 Touyz RM, Schiffrin EL. Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications. Vascular Pharmacology. 45: 19-28. PMID 16782410 DOI: 10.1016/J.Vph.2005.11.014  0.361
2006 Paravicini TM, Touyz RM. Redox signaling in hypertension. Cardiovascular Research. 71: 247-258. PMID 16765337 DOI: 10.1016/J.Cardiores.2006.05.001  0.467
2006 Khan NA, McAlister FA, Rabkin SW, Padwal R, Feldman RD, Campbell NR, Leiter LA, Lewanczuk RZ, Schiffrin EL, Hill MD, Arnold M, Moe G, Campbell TS, Herbert C, Milot A, ... ... Touyz RM, et al. The 2006 Canadian Hypertension Education Program recommendations for the management of hypertension: Part II - Therapy. The Canadian Journal of Cardiology. 22: 583-93. PMID 16755313 DOI: 10.1016/S0828-282X(06)70280-X  0.323
2006 Touyz RM. Highlights and summary of the 2006 Canadian Hypertension Education Program recommendations Canadian Journal of Cardiology. 22: 565-571. PMID 16755311 DOI: 10.1016/S0828-282X(06)70278-1  0.333
2006 Touyz RM. Mitochondrial Redox Control of Matrix Metalloproteinase Signaling in Resistance Arteries Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 685-688. PMID 16556862 DOI: 10.1161/01.Atv.0000216428.90962.60  0.401
2006 Touyz RM. Magnesium and hypertension. Current Opinion in Nephrology and Hypertension. 15: 141-144. PMID 16481880 DOI: 10.1097/01.Mnh.0000214773.34480.D4  0.368
2006 Touyz RM. Lipid Rafts Take Center Stage in Endothelial Cell Redox Signaling by Death Receptors Hypertension. 47: 16-18. PMID 16344370 DOI: 10.1161/01.Hyp.0000196730.13216.F3  0.402
2006 Callera GE, Tostes RC, Yogi A, Montezano ACI, Touyz RM. Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms Clinical Science. 110: 243-253. PMID 16271043 DOI: 10.1042/Cs20050307  0.383
2006 Tabet F, Schiffrin EL, Touyz RM. Mitogen-activated protein kinase activation by hydrogen peroxide is mediated through tyrosine kinase-dependent, protein kinase C-independent pathways in vascular smooth muscle cells: upregulation in spontaneously hypertensive rats. Journal of Hypertension. 23: 2005-12. PMID 16208142 DOI: 10.1097/01.Hjh.0000185715.60788.1B  0.365
2006 Touyz RM, He Y, Montezano AC, Yao G, Chubanov V, Gudermann T, Callera GE. Differential regulation of transient receptor potential melastatin 6 and 7 cation channels by ANG II in vascular smooth muscle cells from spontaneously hypertensive rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 290: R73-8. PMID 16109804 DOI: 10.1152/Ajpregu.00515.2005  0.423
2006 Cruzado MC, Risler NR, Miatello RM, Yao G, Schiffrin EL, Touyz RM. Vascular smooth muscle cell NAD(P)H oxidase activity during the development of hypertension: Effect of angiotensin II and role of insulinlike growth factor-1 receptor transactivation. American Journal of Hypertension. 18: 81-7. PMID 15691621 DOI: 10.1016/J.Amjhyper.2004.09.001  0.443
2006 Savoia C, Touyz RM, Schiffrin EL. Response to Are the Eutrophic Effects of Angiotensin Receptor Blockers Real? Hypertension. 48. DOI: 10.1161/01.Hyp.0000238606.74107.26  0.386
2005 Padwal R, Campbell N, Touyz RM. Applying the 2005 Canadian Hypertension Education Program recommendations: 3. Lifestyle modifications to prevent and treat hypertension. Canadian Medical Association Journal. 173: 749-751. PMID 16186578 DOI: 10.1503/Cmaj.050186  0.33
2005 Callera GE, Montezano AC, Yogi A, Tostes RC, He Y, Schiffrin EL, Touyz RM. c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). 46: 1032-8. PMID 16157790 DOI: 10.1161/01.Hyp.0000176588.51027.35  0.439
2005 Touyz RM. Reactive Oxygen Species as Mediators of Calcium Signaling by Angiotensin II: Implications in Vascular Physiology and Pathophysiology Antioxidants & Redox Signaling. 7: 1302-1314. PMID 16115036 DOI: 10.1089/Ars.2005.7.1302  0.398
2005 De Ciuceis C, Amiri F, Brassard P, Endemann DH, Touyz RM, Schiffrin EL. Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of angiotensin II-infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in angiotensin-induced vascular injury. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 2106-13. PMID 16100037 DOI: 10.1161/01.Atv.0000181743.28028.57  0.422
2005 Santos RAS, Ferreira AJ, Pinheiro SVB, Sampaio WO, Touyz R, Campagnole-Santos MJ. Angiotensin-(1-7) and its receptor as a potential targets for new cardiovascular drugs. Expert Opinion On Investigational Drugs. 14: 1019-1031. PMID 16050794 DOI: 10.1517/13543784.14.8.1019  0.323
2005 Touyz RM. Intracellular mechanisms involved in vascular remodelling of resistance arteries in hypertension: role of angiotensin II. Experimental Physiology. 90: 449-455. PMID 15890798 DOI: 10.1113/Expphysiol.2005.030080  0.467
2005 Savoia C, Tabet F, Yao G, Schiffrin EL, Touyz RM. Negative regulation of RhoA/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle cells: role in angiotensin II-induced vasodilation in stroke-prone spontaneously hypertensive rats. Journal of Hypertension. 23: 1037-45. PMID 15834290 DOI: 10.1097/01.Hjh.0000166845.49850.39  0.396
2005 Touyz RM, Yao G, Schiffrin EL. Role of the actin cytoskeleton in angiotensin II signaling in human vascular smooth muscle cells. Canadian Journal of Physiology and Pharmacology. 83: 91-7. PMID 15759055 DOI: 10.1139/Y05-006  0.389
2005 Touyz RM, Mercure C, He Y, Javeshghani D, Yao G, Callera GE, Yogi A, Lochard N, Reudelhuber TL. Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase. Hypertension. 45: 530-7. PMID 15753233 DOI: 10.1161/01.Hyp.0000158845.49943.5E  0.372
2005 Schiffrin EL, Touyz RM. Calcium, magnesium, and oxidative stress in hyperaldosteronism. Circulation. 111: 830-1. PMID 15723988 DOI: 10.1161/01.Cir.0000157186.95918.78  0.366
2005 Callera GE, Touyz RM, Tostes RC, Yogi A, He Y, Malkinson S, Schiffrin EL. Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src. Hypertension (Dallas, Tex. : 1979). 45: 773-9. PMID 15699470 DOI: 10.1161/01.Hyp.0000154365.30593.D3  0.344
2005 Touyz RM. Molecular and cellular mechanisms in vascular injury in hypertension: role of angiotensin II Current Opinion in Nephrology and Hypertension. 14: 125-131. PMID 15687838 DOI: 10.1097/00041552-200503000-00007  0.476
2005 Beaucage P, Iglarz M, Servant M, Touyz RM, Moreau P. Position of Src tyrosine kinases in the interaction between angiotensin II and endothelin in in vivo vascular protein synthesis. Journal of Hypertension. 23: 329-35. PMID 15662221 DOI: 10.1097/00004872-200502000-00015  0.405
2005 Touyz RM, Yao G, Quinn MT, Pagano PJ, Schiffrin EL. p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells role in NAD(P)H oxidase regulation by angiotensin II Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 512-518. PMID 15618548 DOI: 10.1161/01.Atv.0000154141.66879.98  0.39
2005 Tabet F, Savoia C, Schiffrin EL, Touyz RM. Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology. 44: 200-8. PMID 15243301 DOI: 10.1097/00005344-200408000-00009  0.306
2005 Touyz RM, Yao G, Viel E, Amiri F, Schiffrin EL. Angiotensin II and endothelin-1 regulate MAP kinases through different redox-dependent mechanisms in human vascular smooth muscle cells. Journal of Hypertension. 22: 1141-9. PMID 15167449 DOI: 10.1097/00004872-200406000-00015  0.404
2005 DECIUCEIS C, AMIRI F, ENDEMANN D, TOUYZ R, SCHIFFRIN E. Resistance arteries of Ang II-infused osteopetrotic mice show reduced impairment of endothelial function, oxidative stress, and vascular remodeling: Role of inflammation and mCSF in hypertension American Journal of Hypertension. 18: A242-A242. DOI: 10.1016/J.Amjhyper.2005.03.660  0.431
2005 TOUYZ R, YAO G, SCHIFFRIN E. Role of the actin cytoskeleton in angiotensin II signaling in human vascular smooth muscle cells American Journal of Hypertension. 18: A237-A237. DOI: 10.1016/J.Amjhyper.2005.03.650  0.369
2004 He Y, Yao G, Savoia C, Touyz RM. Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II. Circulation Research. 96: 207-15. PMID 15591230 DOI: 10.1161/01.Res.0000152967.88472.3E  0.364
2004 Amiri F, Virdis A, Neves MF, Iglarz M, Seidah NG, Touyz RM, Reudelhuber TL, Schiffrin EL. Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation. 110: 2233-40. PMID 15466627 DOI: 10.1161/01.Cir.0000144462.08345.B9  0.4
2004 Touyz RM, Schiffrin EL. Reactive oxygen species in vascular biology: implications in hypertension. Histochemistry and Cell Biology. 122: 339-52. PMID 15338229 DOI: 10.1007/S00418-004-0696-7  0.425
2004 Schiffrin EL, Touyz RM. From bedside to bench to bedside: role of renin-angiotensin-aldosterone system in remodeling of resistance arteries in hypertension. American Journal of Physiology. Heart and Circulatory Physiology. 287: H435-46. PMID 15277186 DOI: 10.1152/Ajpheart.00262.2004  0.325
2004 Touyz RM. Reactive oxygen species and angiotensin II signaling in vascular cells -- implications in cardiovascular disease. Brazilian Journal of Medical and Biological Research. 37: 1263-1273. PMID 15273829 DOI: 10.1590/S0100-879X2004000800018  0.466
2004 Touyz RM. Reactive Oxygen Species, Vascular Oxidative Stress, and Redox Signaling in Hypertension What Is the Clinical Significance? Hypertension. 44: 248-252. PMID 15262903 DOI: 10.1161/01.Hyp.0000138070.47616.9D  0.376
2004 Daigle C, Martens FM, Girardot D, Dao HH, Touyz RM, Moreau P. Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo. Bmc Cardiovascular Disorders. 4: 6. PMID 15134586 DOI: 10.1186/1471-2261-4-6  0.38
2004 Endemann DH, Touyz RM, Iglarz M, Savoia C, Schiffrin EL. Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). 43: 1252-7. PMID 15117913 DOI: 10.1161/01.Hyp.0000128031.31572.A3  0.404
2004 Lochard N, Thibault G, Silversides DW, Touyz RM, Reudelhuber TL. Chronic production of angiotensin IV in the brain leads to hypertension that is reversible with an angiotensin II AT1 receptor antagonist. Circulation Research. 94: 1451-7. PMID 15117826 DOI: 10.1161/01.Res.0000130654.56599.40  0.377
2004 Virdis A, Neves MF, Amiri F, Touyz RM, Schiffrin EL. Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice. Journal of Hypertension. 22: 535-42. PMID 15076159 DOI: 10.1097/00004872-200403000-00016  0.388
2004 Callera GE, Montezano AC, Touyz RM, Zorn TM, Carvalho MH, Fortes ZB, Nigro D, Schiffrin EL, Tostes RC. ETA receptor mediates altered leukocyte-endothelial cell interaction and adhesion molecules expression in DOCA-salt rats. Hypertension (Dallas, Tex. : 1979). 43: 872-9. PMID 14993193 DOI: 10.1161/01.Hyp.0000117296.30296.14  0.388
2004 Endemann DH, Pu Q, De Ciuceis C, Savoia C, Virdis A, Neves MF, Touyz RM, Schiffrin EL. Persistent remodeling of resistance arteries in type 2 diabetic patients on antihypertensive treatment. Hypertension (Dallas, Tex. : 1979). 43: 399-404. PMID 14707158 DOI: 10.1161/01.Hyp.0000112029.03691.E7  0.363
2004 El Mabrouk M, Diep QN, Benkirane K, Touyz RM, Schiffrin EL. SAM68: a downstream target of angiotensin II signaling in vascular smooth muscle cells in genetic hypertension. American Journal of Physiology. Heart and Circulatory Physiology. 286: H1954-62. PMID 14693677 DOI: 10.1152/Ajpheart.00134.2003  0.398
2004 Touyz RM, Tabet F, Schiffrin EL. Redox-dependent signalling by angiotensin II and vascular remodelling in hypertension. Clinical and Experimental Pharmacology & Physiology. 30: 860-6. PMID 14678251 DOI: 10.1046/J.1440-1681.2003.03930.X  0.486
2004 Touyz RM, Schiffrin EL. Role of endothelin in human hypertension. Canadian Journal of Physiology and Pharmacology. 81: 533-41. PMID 12839265 DOI: 10.1139/Y03-009  0.422
2004 Schiffrin EL, Touyz RM. Inflammation and vascular hypertrophy induced by angiotensin II: role of NADPH oxidase-derived reactive oxygen species independently of blood pressure elevation? Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 707-9. PMID 12740221 DOI: 10.1161/01.Atv.0000069907.12357.7E  0.477
2004 Silversides DW, Thibault G, Touyz RM, Reudelhuber TL, Lochard N. INTRACELLULAR CALCIUM MOBILIZATION BY ANGIOTENSIN IV IN PRESENCE OF ANGIOTENSIN II IS AT1-DEPENDEN Journal of Hypertension. 22: S172. DOI: 10.1097/00004872-200402001-00730  0.311
2004 Touyz R, Yao G, Viel E, Schiffrin EL. ENDOTHELIN-1 REGULATES MAP KINASES THROUGH MITOCHONDRIAL-DERIVED REACTIVE OXYGEN SPECIES, WHEREAS ANGIOTENSIN II EFFECTS ARE MEDIATED VIA NADPH OXIDASE-DERIVED SUPEROXIDE IN HUMAN VASCULAR SMOOTH MUSCLE CELLS Journal of Hypertension. 22: S112. DOI: 10.1097/00004872-200402001-00476  0.369
2004 Touyz R, Yao G. MAGNESIUM NEGATIVELY REGULATES RHOA/RHO KINASE-DEPENDENT SIGNALING AND CONTRACTION IN VASCULAR SMOOTH MUSCLE CELLS-IMPLICATIONS IN HYPERTENSION Rhian Touyz: P 245 Journal of Hypertension. 22. DOI: 10.1097/00004872-200402001-00318  0.386
2004 Endemann D, Touyz RM, Savoia C, Iglarz M, Schiffrin EL. EPLERENONE PREVENTS CARDIAC AND VASCULAR REMODELING AND IMPROVES RENAL FUNCTION IN SALT-DEPENDENT HYPERTENSION Journal of Hypertension. 22: S72. DOI: 10.1097/00004872-200402001-00299  0.385
2004 Savoia C, Schiffrin EL, Touyz RM. ANGIOTENSIN II-INDUCED AT2 STIMULATION NEGATIVELY MODULATES RHO KINASE-DEPENDENT PHOSPHORYLATION OF MYOSIN LIGHT CHAIN IN VASCULAR SMOOTH MUSCLE CELLS AND PROMOTES VASORELAXATION IN SHRSP RESISTANCE ARTERIES Journal of Hypertension. 22: S62. DOI: 10.1097/00004872-200402001-00259  0.37
2004 Touyz R, Endemann D, He Y, Yao G, Savoia C, Virdis A, Schiffrin EL. ANGIOTENSIN II-INDUCED HYPERTENSION IS DEPENDENT ON FUNCTIONALLY ACTIVE C-SRCTYROSINE KINASE, BUT NOT FYN Journal of Hypertension. 22: S59. DOI: 10.1097/00004872-200402001-00246  0.378
2004 IGLARZ M, TOUYZ R, VIEL E, AMIRI F, SCHIFFRIN E. American Journal of Hypertension. 17: 597-603. DOI: 10.1016/J.Amjhyper.2004.04.005  0.394
2004 TOUYZ R. Presence of functionally active mg2+ uptake channels, TRPM6 and TRPM7, in vascular smooth muscle cells from WKY and SHR? differential regulation by aldosterone and angiotensin II American Journal of Hypertension. 17: S176. DOI: 10.1016/J.Amjhyper.2004.03.463  0.349
2004 TOUYZ R. Aldosterone activates ERK1/2 and p38map kinase in vascular smooth muscle cells by nongenomic mechanisms in WKY and SHR ? role of endothelin-1 American Journal of Hypertension. 17: S159. DOI: 10.1016/J.Amjhyper.2004.03.418  0.366
2003 Touyz RM. Reactive oxygen species in vascular biology: role in arterial hypertension. Expert Review of Cardiovascular Therapy. 1: 91-106. PMID 15030300 DOI: 10.1586/14779072.1.1.91  0.336
2003 Touyz RM. Activated oxygen metabolites: do they really play a role in angiotensin II-regulated vascular tone? Journal of Hypertension. 21: 2235-2238. PMID 14654739 DOI: 10.1097/01.Hjh.0000084795.15238.D9  0.388
2003 Schiffrin EL, Touyz RM. Multiple actions of angiotensin II in hypertension: benefits of AT1 receptor blockade. Journal of the American College of Cardiology. 42: 911-3. PMID 12957442 DOI: 10.1016/S0735-1097(03)00845-3  0.373
2003 Callera GE, Touyz RM, Teixeira SA, Muscara MN, Carvalho MH, Fortes ZB, Nigro D, Schiffrin EL, Tostes RC. ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension. Hypertension (Dallas, Tex. : 1979). 42: 811-7. PMID 12913063 DOI: 10.1161/01.Hyp.0000088363.65943.6C  0.431
2003 Javeshghani D, Touyz RM, Sairam MR, Virdis A, Neves MF, Schiffrin EL. Attenuated responses to angiotensin II in follitropin receptor knockout mice, a model of menopause-associated hypertension. Hypertension. 42: 761-7. PMID 12885794 DOI: 10.1161/01.Hyp.0000085331.22169.3F  0.41
2003 Iglarz M, Touyz RM, Viel EC, Paradis P, Amiri F, Diep QN, Schiffrin EL. Peroxisome proliferator-activated receptor-alpha and receptor-gamma activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension. Hypertension (Dallas, Tex. : 1979). 42: 737-43. PMID 12860836 DOI: 10.1161/01.Hyp.0000083511.91817.B1  0.356
2003 Virdis A, Iglarz M, Neves MF, Amiri F, Touyz RM, Rozen R, Schiffrin EL. Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 1352-7. PMID 12829522 DOI: 10.1161/01.Atv.0000083297.47245.Da  0.379
2003 Pu Q, Neves MF, Virdis A, Touyz RM, Schiffrin EL. Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling. Hypertension (Dallas, Tex. : 1979). 42: 49-55. PMID 12782645 DOI: 10.1161/01.Hyp.0000078357.92682.Ec  0.437
2003 Touyz RM, Yao G. Up-regulation of vascular and renal mitogen-activated protein kinases in hypertensive rats is normalized by inhibitors of the Na+/Mg2+ exchanger Clinical Science. 105: 235-242. PMID 12725644 DOI: 10.1042/Cs20030033  0.415
2003 Touyz RM. Pressure-induced expression of vascular neuronal nitric oxide synthase: adaptive or maladaptive response in arteries? Journal of Hypertension. 21: 863-865. PMID 12714856 DOI: 10.1097/00004872-200305000-00006  0.349
2003 Touyz RM, Cruzado M, Tabet F, Yao G, Salomon S, Schiffrin EL. Redox-dependent MAP kinase signaling by Ang II in vascular smooth muscle cells: role of receptor tyrosine kinase transactivation. Canadian Journal of Physiology and Pharmacology. 81: 159-67. PMID 12710530 DOI: 10.1139/Y02-164  0.37
2003 Touyz RM, Yao G, Schiffrin EL. c-Src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 981-7. PMID 12663375 DOI: 10.1161/01.Atv.0000069236.27911.68  0.394
2003 Touyz RM. The role of angiotensin II in regulating vascular structural and functional changes in hypertension. Current Hypertension Reports. 5: 155-164. PMID 12642016 DOI: 10.1007/S11906-003-0073-2  0.461
2003 Touyz RM. Recent advances in intracellular signalling in hypertension. Current Opinion in Nephrology and Hypertension. 12: 165-174. PMID 12589177 DOI: 10.1097/00041552-200303000-00007  0.453
2003 Iglarz M, Touyz RM, Amiri F, Lavoie MF, Diep QN, Schiffrin EL. Effect of peroxisome proliferator-activated receptor-alpha and -gamma activators on vascular remodeling in endothelin-dependent hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 45-51. PMID 12524223 DOI: 10.1161/01.Atv.0000047447.67827.Cd  0.367
2003 Diep QN, Amiri F, Touyz RM, Cohn JS, Endemann D, Neves MF, Schiffrin EL. PPARalpha activator effects on Ang II-induced vascular oxidative stress and inflammation. Hypertension (Dallas, Tex. : 1979). 40: 866-71. PMID 12468571 DOI: 10.1161/01.Hyp.0000037969.41360.Cc  0.457
2003 Touyz RM, Pu Q, He G, Chen X, Yao G, Neves MF, Viel E. Effects of low dietary magnesium intake on development of hypertension in stroke-prone spontaneously hypertensive rats: role of reactive oxygen species. Journal of Hypertension. 20: 2221-32. PMID 12409961 DOI: 10.1097/00004872-200211000-00022  0.387
2002 Virdis A, Neves MF, Amiri F, Viel E, Touyz RM, Schiffrin EL. Spironolactone improves angiotensin-induced vascular changes and oxidative stress. Hypertension (Dallas, Tex. : 1979). 40: 504-10. PMID 12364354 DOI: 10.1161/01.Hyp.0000034738.79310.06  0.434
2002 Touyz RM, Berry C. Recent advances in angiotensin II signaling Brazilian Journal of Medical and Biological Research. 35: 1001-1015. PMID 12219172 DOI: 10.1590/S0100-879X2002000900001  0.4
2002 Tostes RC, Touyz RM, He G, Chen X, Schiffrin EL. Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension. Clinical Science (London, England : 1979). 25S-30S. PMID 12193048 DOI: 10.1042/Cs103S025S  0.332
2002 Endemann D, Touyz RM, Yao G, Schiffrin EL. Tyrosine kinase inhibition attenuates vasopressin-induced contraction of mesenteric resistance arteries: alterations in spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology. 40: 123-32. PMID 12072585 DOI: 10.1097/00005344-200207000-00015  0.382
2002 Touyz RM, Chen X, Tabet F, Yao G, He G, Quinn MT, Pagano PJ, Schiffrin EL. Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: Regulation by angiotensin II Circulation Research. 90: 1205-1213. PMID 12065324 DOI: 10.1161/01.Res.0000020404.01971.2F  0.389
2002 Touyz RM, Deschepper C, Park JB, He G, Chen X, Neves MF, Virdis A, Schiffrin EL. Inhibition of mitogen-activated protein/extracellular signal-regulated kinase improves endothelial function and attenuates Ang II-induced contractility of mesenteric resistance arteries from spontaneously hypertensive rats. Journal of Hypertension. 20: 1127-34. PMID 12023682 DOI: 10.1097/00004872-200206000-00024  0.452
2002 Tostes RC, Touyz RM, He G, Ammarguellat F, Schiffrin EL. Endothelin A receptor blockade decreases expression of growth factors and collagen and improves matrix metalloproteinase-2 activity in kidneys from stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology. 39: 892-900. PMID 12021584 DOI: 10.1097/00005344-200206000-00015  0.318
2002 Pu Q, Touyz RM, Schiffrin EL. Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats. Journal of Hypertension. 20: 899-907. PMID 12011651 DOI: 10.1097/00004872-200205000-00025  0.359
2002 Touyz RM, Wu XH, He G, Salomon S, Schiffrin EL. Increased angiotensin II-mediated Src signaling via epidermal growth factor receptor transactivation is associated with decreased C-terminal Src kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). 39: 479-85. PMID 11882594 DOI: 10.1161/Hy02T2.102909  0.403
2002 Touyz RM. Impaired vasorelaxation in hypertension: beyond the endothelium. Journal of Hypertension. 20: 371-373. PMID 11875299 DOI: 10.1097/00004872-200203000-00007  0.387
2002 Park JB, Touyz RM, Chen X, Schiffrin EL. Chronic treatment with a superoxide dismutase mimetic prevents vascular remodeling and progression of hypertension in salt-loaded stroke-prone spontaneously hypertensive rats. American Journal of Hypertension. 15: 78-84. PMID 11824865 DOI: 10.1016/S0895-7061(01)02233-6  0.438
2002 Touyz RM, Yao G. P-331: Inhibition of the Na+/Mg2+ exchanger decreases blood pressure and modulates vascular ERK1/2 and p38 MAP kinase phosphorylation in Ang II-induced hypertensive rats American Journal of Hypertension. 15. DOI: 10.1016/S0895-7061(02)02682-1  0.405
2002 TOUYZ R. Src is an upstream regulator of NADPH oxidase in human vascular smooth muscle cells American Journal of Hypertension. 15: A11. DOI: 10.1016/S0895-7061(02)02302-6  0.335
2001 Touyz RM, Schiffrin EL. Measurement of phospholipase d activation in vascular smooth muscle cells. Methods in Molecular Medicine. 51: 355-362. PMID 21331729 DOI: 10.1385/1-59259-087-X:355  0.374
2001 Berry C, Touyz R, Dominiczak AF, Webb RC, Johns DG. Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. American Journal of Physiology. Heart and Circulatory Physiology. 281: H2337-65. PMID 11709400 DOI: 10.1152/Ajpheart.2001.281.6.H2337  0.392
2001 Chen X, Touyz RM, Park JB, Schiffrin EL. Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR. Hypertension (Dallas, Tex. : 1979). 38: 606-11. PMID 11566940 DOI: 10.1161/Hy09T1.094005  0.349
2001 Touyz RM, He G, Wu XH, Park JB, Mabrouk ME, Schiffrin EL. Src is an important mediator of extracellular signal-regulated kinase 1/2-dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients. Hypertension (Dallas, Tex. : 1979). 38: 56-64. PMID 11463760 DOI: 10.1161/01.Hyp.38.1.56  0.354
2001 Touyz RM, Schiffrin EL. Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways. Journal of Hypertension. 19: 1245-54. PMID 11446714 DOI: 10.1097/00004872-200107000-00009  0.42
2001 El Mabrouk M, Touyz RM, Schiffrin EL. Differential ANG II-induced growth activation pathways in mesenteric artery smooth muscle cells from SHR. American Journal of Physiology. Heart and Circulatory Physiology. 281: H30-9. PMID 11406465 DOI: 10.1152/Ajpheart.2001.281.1.H30  0.405
2001 Touyz RM, He G, El Mabrouk M, Diep Q, Mardigyan V, Schiffrin EL. Differential activation of extracellular signal-regulated protein kinase 1/2 and p38 mitogen activated-protein kinase by AT1 receptors in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats. Journal of Hypertension. 19: 553-9. PMID 11327629 DOI: 10.1097/00004872-200103001-00006  0.382
2001 Touyz RM, Wu XH, He G, Park JB, Chen X, Vacher J, Rajapurohitam V, Schiffrin EL. Role of c-Src in the regulation of vascular contraction and Ca2+ signaling by angiotensin II in human vascular smooth muscle cells. Journal of Hypertension. 19: 441-9. PMID 11288814 DOI: 10.1097/00004872-200103000-00012  0.415
2001 Touyz RM, Mercure C, Reudelhuber TL. Angiotensin II Type I Receptor Modulates Intracellular Free Mg 2+ in Renally Derived Cells via Na+-dependent Ca 2+-independent Mechanisms Journal of Biological Chemistry. 276: 13657-13663. PMID 11278387 DOI: 10.1074/Jbc.M008101200  0.32
2001 Diep QN, El Mabrouk M, Touyz RM, Schiffrin EL. Expression of cell cycle proteins in blood vessels of angiotensin II-infused rats: role of AT(1) receptors. Hypertension. 37: 604-8. PMID 11230342 DOI: 10.1161/01.Hyp.37.2.604  0.385
2001 Touyz RM, He G, El Mabrouk M, Schiffrin EL. p38 Map kinase regulates vascular smooth muscle cell collagen synthesis by angiotensin II in SHR but not in WKY. Hypertension. 37: 574-80. PMID 11230337 DOI: 10.1161/01.Hyp.37.2.574  0.379
2001 Touyz RM, Turgeon A, Schiffrin EL. Endothelin-A-receptor blockade improves renal function and doubles the lifespan of stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology. 36: S300-4. PMID 11078404 DOI: 10.1097/00005344-200036051-00088  0.314
2001 Touyz R. In vivo inhibition of ERK1/2-dependent signaling pathways improves vascular function in SHR American Journal of Hypertension. 14: A130. DOI: 10.1016/S0895-7061(01)01474-1  0.344
2001 Touyz R. ANG II activates P38 MAP kinase and ERK1/2, but not JNK, in vascular smooth muscle cells from SHR American Journal of Hypertension. 14: A19. DOI: 10.1016/S0895-7061(01)01358-9  0.368
2000 Diep QN, Touyz RM, Schiffrin EL. Docosahexaenoic acid, a peroxisome proliferator-activated receptor-alpha ligand, induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. Hypertension (Dallas, Tex. : 1979). 36: 851-5. PMID 11082155 DOI: 10.1161/01.Hyp.36.5.851  0.349
2000 Laurant P, Touyz RM. Physiological and pathophysiological role of magnesium in the cardiovascular system: implications in hypertension. Journal of Hypertension. 18: 1177-1191. PMID 10994748 DOI: 10.1097/00004872-200018090-00003  0.429
2000 El Mabrouk M, Singh A, Touyz RM, Schiffrin EL. Antiproliferative effect of L-NAME on rat vascular smooth muscle cells. Life Sciences. 67: 1613-23. PMID 10983855 DOI: 10.1016/S0024-3205(00)00744-X  0.325
2000 Touyz RM. Oxidative stress and vascular damage in hypertension. Current Hypertension Reports. 2: 98-105. PMID 10981135 DOI: 10.1007/S11906-000-0066-3  0.351
2000 Tea BS, Der Sarkissian S, Touyz RM, Hamet P, deBlois D. Proapoptotic and growth-inhibitory role of angiotensin II type 2 receptor in vascular smooth muscle cells of spontaneously hypertensive rats in vivo. Hypertension. 35: 1069-73. PMID 10818066 DOI: 10.1161/01.Hyp.35.5.1069  0.363
2000 Schiffrin EL, Park JB, Intengan HD, Touyz RM. Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan. Circulation. 101: 1653-9. PMID 10758046 DOI: 10.1161/01.Cir.101.14.1653  0.42
2000 Fareh J, Touyz RM, Schiffrin EL, Thibault G. Altered cardiac endothelin receptors and protein kinase C in deoxycorticosterone-salt hypertensive rats. Journal of Molecular and Cellular Cardiology. 32: 665-76. PMID 10756122 DOI: 10.1006/Jmcc.2000.1110  0.319
2000 Touyz RM, He G, Wu X, Park JB, Mabrouk ME, Schiffrin EL. Src-Dependent Erk1/2-Mediated Signaling Pathways and Associated Ang Ii-Stimulated Growth Responses Are Altered in Vascular Smooth Muscle Cells from Arteries of Hypertensive Patients. Hypertension. 36: 721-721. DOI: 10.1161/01.Hyp.36.Suppl_1.721-A  0.432
2000 Tostes RCA, Touyz RM, He G, Schiffrin EL. Improved Renal Function by Eta Receptor Blockade Is Associated with Reduced Renal Expression of Tgfβ and B FGF and Increased Activity of Mmp-2 in Shrsp Hypertension. 36: 712-712. DOI: 10.1161/01.Hyp.36.Suppl_1.712  0.319
2000 Touyz RM, He G, Wu X, Mabrouk ME, Schiffrin EL. P38 MAP Kinase Regulates Vascular Smooth Muscle Cell (VSMC) Collagen Synthesis by Ang II in Shr But not in Wky. Hypertension. 36: 707-707. DOI: 10.1161/01.Hyp.36.Suppl_1.707-D  0.399
2000 Diep QN, Mabrouk ME, Touyz RM, Schiffrin EL. Expression of Cell Cycle Proteins P21waf1/Cip1, P27kip1, Cyclin D1 and CDK4 in Blood Vessels of Angiotensin II-Infused Rats. Role of AT1 Receptors. Hypertension. 36: 707-707. DOI: 10.1161/01.Hyp.36.Suppl_1.707-B  0.376
2000 Park JB, Touyz RM, Chen X, Schiffrin EL. Tempol, Vitamin C and Vitamin E Improve Endothelial Dysfunction, Regress Vascular Hypertrophy and Prevent Progression of Hypertension and Renal Dysfunction in Stroke-Prone Shr Hypertension. 36: 699-699. DOI: 10.1161/01.Hyp.36.Suppl_1.699-B  0.384
2000 Touyz RM, Chen X, Park JB, Schiffrin EL. Attenuated Development of Hypertension by Antioxidant Vitamins in Stroke-Prone Shr Is Associated with Increased Vascular Superoxide Dismutase Activity and Decreased Oxidative Stress. Hypertension. 36: 699-699. DOI: 10.1161/01.Hyp.36.Suppl_1.699-A  0.378
2000 Touyz RM, Schiffrin EL. Increased Generation of Vascular Reactive Oxygen Species by Ang II Is Mediated Via Src-Dependent Pathways in Essential Hypertension. Hypertension. 36: 685-685. DOI: 10.1161/01.Hyp.36.Suppl_1.685-B  0.458
2000 Touyz R. Antioxidant vitamins inhibit progression of hypertension and improve endothelial dysfunction and antioxidant status in SHRSP American Journal of Hypertension. 13: S20. DOI: 10.1016/S0895-7061(00)00350-2  0.372
1999 Touyz RM, Schiffrin EL. Ang II-stimulated superoxide production is mediated via phospholipase D in human vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979). 34: 976-82. PMID 10523394 DOI: 10.1161/01.Hyp.34.4.976  0.392
1999 Touyz RM, Schiffrin EL. Activation of the Na(+)-H+ exchanger modulates angiotensin II-stimulated Na(+)-dependent Mg2+ transport in vascular smooth muscle cells in genetic hypertension. Hypertension (Dallas, Tex. : 1979). 34: 442-9. PMID 10489391 DOI: 10.1161/01.Hyp.34.3.442  0.343
1999 Touyz RM, Milne FJ. Magnesium supplementation attenuates, but does not prevent, development of hypertension in spontaneously hypertensive rats. American Journal of Hypertension. 12: 757-765. PMID 10480467 DOI: 10.1016/S0895-7061(99)00064-3  0.303
1999 Touyz RM, Deng LY, He G, Wu XH, Schiffrin EL. Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries: role of extracellular signal-regulated kinases. Journal of Hypertension. 17: 907-16. PMID 10419063 DOI: 10.1097/00004872-199917070-00006  0.399
1999 Endemann D, Touyz RM, Li JS, Deng LY, Schiffrin EL. Altered angiotensin II-induced small artery contraction during the development of hypertension in spontaneously hypertensive rats. American Journal of Hypertension. 12: 716-23. PMID 10411369 DOI: 10.1016/S0895-7061(99)00036-9  0.429
1999 Touyz RM, El Mabrouk M, He G, Wu XH, Schiffrin EL. Mitogen-activated protein/extracellular signal-regulated kinase inhibition attenuates angiotensin II-mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells. Circulation Research. 84: 505-15. PMID 10082472 DOI: 10.1161/01.Res.84.5.505  0.396
1999 Touyz RM, Endemann D, He G, Li JS, Schiffrin EL. Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR. Hypertension (Dallas, Tex. : 1979). 33: 366-72. PMID 9931131 DOI: 10.1161/01.Hyp.33.1.366  0.383
1999 Touyz RM, He G, Deng LY, Schiffrin EL. Role of extracellular signal-regulated kinases in angiotensin II-stimulated contraction of smooth muscle cells from human resistance arteries. Circulation. 99: 392-9. PMID 9918526 DOI: 10.1161/01.Cir.99.3.392  0.375
1998 Sharifi AM, He G, Touyz RM, Schiffrin EL. Vascular endothelin-1 expression and effect of an endothelin ETA antagonist on structure and function of small arteries from stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology. S309-12. PMID 9595467 DOI: 10.1097/00005344-199800001-00086  0.37
1998 Touyz RM, Fareh J, Thibault G, Schiffrin EL. Endothelin-1 signaling is altered in cardiac cells from deoxycorticosterone acetate-salt hypertensive rats. Journal of Cardiovascular Pharmacology. S179-81. PMID 9595432 DOI: 10.1097/00005344-199800001-00051  0.337
1998 Li JS, Touyz RM, Schiffrin EL. Effects of AT1 and AT2 angiotensin receptor antagonists in angiotensin II-infused rats. Hypertension (Dallas, Tex. : 1979). 31: 487-92. PMID 9453350 DOI: 10.1161/01.Hyp.31.1.487  0.36
1998 Touyz RM, Schiffrin EL. Role of calcium influx and intracellular calcium stores in angiotensin II-mediated calcium hyper-responsiveness in smooth muscle from spontaneously hypertensive rats. Journal of Hypertension. 15: 1431-9. PMID 9431849 DOI: 10.1097/00004872-199715120-00010  0.378
1998 TOUYZ R. A030 Angiotensin II-activated map kinase pathways are associated with sustained vascular smooth muscle contraction American Journal of Hypertension. 11: 38A. DOI: 10.1016/S0895-7061(97)90838-4  0.343
1998 TOUYZ R. A029 Inhibition of mitogen-activated protein kinase attenuates and II-induced alkalinization and contraction in SHR vascular smooth muscle cells American Journal of Hypertension. 11: 38A. DOI: 10.1016/S0895-7061(97)90837-2  0.36
1998 TOUYZ R. Angiotensin II induced hyperplasia and hypertrophy in human vascular smooth muscle cells are mediated via AT1 receptors American Journal of Hypertension. 11: 11A. DOI: 10.1016/S0895-7061(97)90742-1  0.391
1997 Fareh J, Touyz RM, Schiffrin EL, Thibault G. Cardiac type-1 angiotensin II receptor status in deoxycorticosterone acetate-salt hypertension in rats. Hypertension (Dallas, Tex. : 1979). 30: 1253-9. PMID 9369284 DOI: 10.1161/01.Hyp.30.5.1253  0.395
1997 Touyz RM, Schiffrin EL. Angiotensin II regulates vascular smooth muscle cell pH, contraction, and growth via tyrosine kinase-dependent signaling pathways. Hypertension (Dallas, Tex. : 1979). 30: 222-9. PMID 9260984 DOI: 10.1161/01.Hyp.30.2.222  0.398
1997 Lacroix A, Tremblay J, Touyz RM, Deng LY, Lariviere R, Cusson JR, Schiffrin EL, Hamet P. Abnormal adrenal and vascular responses to vasopressin mediated by a V1-vasopressin receptor in a patient with adrenocorticotropin-independent macronodular adrenal hyperplasia, Cushing's syndrome, and orthostatic hypotension Journal of Clinical Endocrinology and Metabolism. 82: 2414-2422. PMID 9253310 DOI: 10.1210/Jcem.82.8.4140  0.324
1997 Laurant P, Touyz RM, Schiffrin EL. Effect of pressurization on mechanical properties of mesenteric small arteries from spontaneously hypertensive rats. Journal of Vascular Research. 34: 117-25. PMID 9167644 DOI: 10.1159/000159209  0.334
1997 Methot D, LaPointe MC, Touyz RM, Yang XP, Carretero OA, Deschepper CF, Schiffrin EL, Thibault G, Reudelhuber TL. Tissue targeting of angiotensin peptides Journal of Biological Chemistry. 272: 12994-12999. PMID 9148907 DOI: 10.1074/Jbc.272.20.12994  0.309
1997 Schiffrin EL, Lariviere R, Touyz RM. ETA and ETB receptors on vascular smooth muscle cells from mesenteric vessels of spontaneously hypertensive rats. Clinical and Experimental Pharmacology & Physiology. Supplement. 22: S193-4. PMID 9072351 DOI: 10.1111/J.1440-1681.1995.Tb02877.X  0.361
1997 Schiffrin EL, Lariviere R, Li JS, Sventek P, Touyz RM. Endothelin-1 gene expression and vascular hypertrophy in DOCA-salt hypertension compared to spontaneously hypertensive rats. Clinical and Experimental Pharmacology & Physiology. Supplement. 22: S188-90. PMID 9072349 DOI: 10.1111/J.1440-1681.1995.Tb02875.X  0.402
1997 Laurant P, Touyz RM, Schiffrin EL. Effect of magnesium on vascular tone and reactivity in pressurized mesenteric resistance arteries from spontaneously hypertensive rats Canadian Journal of Physiology and Pharmacology. 75: 293-300. DOI: 10.1139/Y97-044  0.4
1997 Schiffrin EL, Intengan HD, Thibault G, Touyz RM. Clinical significance of endothelin in cardiovascular disease Current Opinion in Cardiology. 12: 354-367. DOI: 10.1097/00001573-199707000-00003  0.43
1996 Yang XP, Touyz RM, Nguyen PV, Deng LY, Li JS, Schiffrin EL. Endothelin-1 and vasopressin signalling in blood vessels of young SHR in comparison to adult SHR. Hypertension Research : Official Journal of the Japanese Society of Hypertension. 19: 121-32. PMID 10968205 DOI: 10.1291/Hypres.19.121  0.385
1996 Touyz RM, Fareh J, Thibault G, Schiffrin EL. Intracellular Ca2+ modulation by angiotensin II and endothelin-1 in cardiomyocytes and fibroblasts from hypertrophied hearts of spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). 28: 797-805. PMID 8901826 DOI: 10.1161/01.Hyp.28.5.797  0.387
1996 Touyz RM, Schiffrin EL. Angiotensin II and vasopressin modulate intracellular free magnesium in vascular smooth muscle cells through Na+-dependent protein kinase C pathways. The Journal of Biological Chemistry. 271: 24353-8. PMID 8798689 DOI: 10.1074/Jbc.271.40.24353  0.35
1996 Touyz RM, Fareh J, Thibault G, Tolloczko B, Larivière R, Schiffrin EL. Modulation of Ca2+ transients in neonatal and adult rat cardiomyocytes by angiotensin II and endothelin-1. The American Journal of Physiology. 270: H857-68. PMID 8780179 DOI: 10.1152/Ajpheart.1996.270.3.H857  0.338
1996 Touyz RM, Schiffrin EL. Tyrosine kinase signaling pathways modulate angiotensin II-induced calcium ([Ca2+]i) transients in vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979). 27: 1097-103. PMID 8621202 DOI: 10.1161/01.Hyp.27.5.1097  0.375
1996 Touyz RM, Sventek P, Larivière R, Thibault G, Fareh J, Reudelhuber T, Schiffrin EL. Cytosolic calcium changes induced by angiotensin II in neonatal rat atrial and ventricular cardiomyocytes are mediated via angiotensin II subtype 1 receptors. Hypertension (Dallas, Tex. : 1979). 27: 1090-6. PMID 8621201 DOI: 10.1161/01.Hyp.27.5.1090  0.343
1996 Fareh J, Touyz RM, Schiffrin EL, Thibault G. Endothelin-1 and angiotensin II receptors in cells from rat hypertrophied heart. Receptor regulation and intracellular Ca2+ modulation. Circulation Research. 78: 302-11. PMID 8575074 DOI: 10.1161/01.Res.78.2.302  0.344
1996 Fareh J, Touyz RM, Thibault G, Schiffrin EL. Basal and angiotensin II-induced cytosolic free calcium in adult rat cardiomyocytes and fibroblasts after volume overload. Hypertension (Dallas, Tex. : 1979). 26: 1149-53. PMID 7498986 DOI: 10.1161/01.Hyp.26.6.1149  0.317
1996 Touyz RM, Deng LY, Schiffrin EL. Endothelin subtype B receptor-mediated calcium and contractile responses in small arteries of hypertensive rats. Hypertension (Dallas, Tex. : 1979). 26: 1041-5. PMID 7498964 DOI: 10.1161/01.Hyp.26.6.1041  0.383
1996 Touyz RM, Deng L, Li J, Schiffrin EL. Differential effects of vasopressin and endothelin-1 on vascular contractile and calcium responses in pressurized small arteries from spontaneously hypertensive rats Journal of Hypertension. 14: 983???992. DOI: 10.1097/00004872-199715080-00016  0.337
1995 Touyz RM, Lariviere R, Schiffrin EL. Endothelin receptor subtypes in mesenteric vascular smooth muscle cells of spontaneously hypertensive rats Canadian Journal of Physiology and Pharmacology. 73: 1262-1273. PMID 8748975 DOI: 10.1139/Y95-178  0.342
1995 Touyz RM, Milne FJ. Alterations in intracellular cations and cell membrane ATPase activity in patients with malignant hypertension Journal of Hypertension. 13: 867-874. PMID 8557964 DOI: 10.1097/00004872-199508000-00007  0.346
1995 Touyz RM, Tolloczko B, Schiffrin EL. Blunted attenuation of angiotensin II-mediated Ca2+ transients by insulin in cultured unpassaged vascular smooth muscle cells from spontaneously hypertensive rats. American Journal of Hypertension. 8: 104-12. PMID 7755938 DOI: 10.1016/0895-7061(94)00173-9  0.354
1995 Schiffrin EL, Lariviere R, Li JS, Sventek P, Touyz RM. Deoxycorticosterone acetate plus salt induces overexpression of vascular endothelin-1 and severe vascular hypertrophy in spontaneously hypertensive rats Hypertension. 25: 769-773. PMID 7721430 DOI: 10.1161/01.Hyp.25.4.769  0.419
1995 Touyz RM, Deng LY, Schiffrin EL. Ca2+ and Contractile Responses of Resistance Vessels of WKY Rats and SHR to Endothelin-1 Journal of Cardiovascular Pharmacology. 26: S193-196. DOI: 10.1097/00005344-199506263-00058  0.324
1995 Schiffrin EL, Larivière R, Li J, Sventek P, Touyz RM. Enhanced Expression of Endothelin-1 Gene May Cause Blood Pressure-Independent Vascular Hypertrophy Journal of Cardiovascular Pharmacology. 26: S5-8. DOI: 10.1097/00005344-199506263-00003  0.385
1994 Touyz RM, Schiffrin EL. Effects of angiotensin II and endothelin-1 on platelet aggregation and cytosolic pH and free Ca2+ concentrations in essential hypertension. Hypertension (Dallas, Tex. : 1979). 22: 853-62. PMID 8244517 DOI: 10.1161/01.Hyp.22.6.853  0.361
1994 Touyz RM, Schiffrin EL. Insulin-induced Ca2+ transport is altered in vascular smooth muscle cells of spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). 23: 931-5. PMID 8206630 DOI: 10.1161/01.Hyp.23.6.931  0.319
1994 Touyz RM, Schiffrin EL. Signal transduction in hypertension: Part I. Current Opinion in Nephrology and Hypertension. 2: 5-16. PMID 7922167 DOI: 10.1097/00041552-199301000-00003  0.391
1994 Touyz RM, Tolloczko B, Schiffrin EL. Insulin attenuates agonist-evoked calcium transients in vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979). 23: I25-8. PMID 7506699 DOI: 10.1161/01.Hyp.23.1_Suppl.I25  0.31
1994 Touyz RM, Schiffrin EL. Blunted inhibition by insulin of agonist-stimulated calcium, pH and aggregatory responses in platelets from hypertensive patients Journal of Hypertension. 12: 1255???1264. DOI: 10.1097/00004872-199411000-00008  0.301
1994 Touyz RM, Tolloczko B, Schiffrin EL. Mesenteric vascular smooth muscle cells from spontaneously hypertensive rats display increased calcium responses to angiotensin II but not to endothelin-1 Journal of Hypertension. 12: 663???674. DOI: 10.1097/00004872-199406000-00006  0.374
1993 Touyz RM, Schiffrin EL. The effect of angiotensin II on platelet intracellular free magnesium and calcium ionic concentrations in essential hypertension. Journal of Hypertension. 11: 551-8. PMID 8390527 DOI: 10.1097/00004872-199305000-00011  0.345
1993 Touyz RM, Milne FJ, Reinach SG. Racial Differences in Cell Membrane ATPases and Cellular Cation Content in Urban South African Normotensive and Hypertensive Subjects American Journal of Hypertension. 6: 693-700. PMID 8105809 DOI: 10.1093/Ajh/6.8.693  0.313
1993 Touyz R, Schiffrin EL. Biology of Blood Vessels in Hypertension Cardiology in Review. 1: 87-96. DOI: 10.1097/00045415-199301020-00004  0.42
1992 Touyz RM, Milne FJ, Reinach SG. Intracellular Mg2+, Ca2+, Na2+ and K+ in platelets and erythrocytes of essential hypertension patients: relation to blood pressure. Clinical and Experimental Hypertension. 14: 1189-1209. PMID 1424223 DOI: 10.3109/10641969209038200  0.313
1991 Touyz RM, Marshall PR, Milne FJ. Altered cations and muscle membrane ATPase activity in deoxycorticosterone acetate-salt spontaneously hypertensive rats. Journal of Hypertension. 9: 737-750. PMID 1655884 DOI: 10.1097/00004872-199108000-00007  0.344
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