Paul W. Fedak, Ph.D. - Publications

Affiliations: 
2004 University of Toronto, Toronto, ON, Canada 
Area:
Medicine and Surgery, Cell Biology, Animal Physiology Biology

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Prasher D, Zhang H, McCarthy PM, Oudit G, Fedak PW, Greenway SC. Abstract 656: Construction and Application of an Epigenetic Atlas of the Human Heart Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.656  0.307
2017 Svystonyuk D, Turnbull J, Teng G, Belke D, Guzzardi D, Park D, Kang S, Fedak P. ACELLULAR EXTRACELLULAR MATRIX SCAFFOLD REPROGRAMS CARDIAC FIBROBLASTS AND PROMOTES ADAPTIVE CARDIAC REMODELING AND REPAIR Canadian Journal of Cardiology. 33: S49-S50. DOI: 10.1016/J.Cjca.2017.07.485  0.375
2017 Kang S, Verma S, Teng G, Belke D, Svystonyuk D, Guzzardi D, Park D, Turnbull J, Malik G, Fedak P. DIRECT EFFECTS OF EMPAGLIFLOZIN ON EXTRACELLULAR MATRIX REMODELING IN HUMAN CARDIAC FIBROBLASTS: NOVEL TRANSLATIONAL CLUES TO EMPA-REG OUTCOME Canadian Journal of Cardiology. 33: S169. DOI: 10.1016/J.Cjca.2017.07.330  0.439
2017 Park D, Regmi S, Svystonyuk D, Belke D, Teng G, Turnbull J, Guzzardi D, Kang S, Schmidt T, Fedak P. IMPLICATIONS OF PRG4/LUBRICIN IN ATTENUATING MYOFIBROBLAST-MEDIATED INTRATHORACIC ADHESION DEVELOPMENT AFTER CARDIAC SURGERY Canadian Journal of Cardiology. 33: S92-S93. DOI: 10.1016/J.Cjca.2017.07.183  0.317
2017 Guzzardi D, Teng G, Svystonyuk D, Kang S, Park D, Belke D, Turnbull J, Fedak P. FLUOROQUINOLONE INDUCES HUMAN AORTIC FIBROBLAST-MEDIATED EXTRACELLULAR MATRIX DYSREGULATION Canadian Journal of Cardiology. 33: S38-S39. DOI: 10.1016/J.Cjca.2017.07.092  0.311
2016 Svystonyuk D, Mewhort H, Turnbull J, Teng G, Belke D, Guzzardi D, Park D, Kang S, Fedak P. EXTRACELLULAR MATRIX BIOMATERIAL PROMOTES VASCULOGENESIS AND CARDIAC REPAIR: EVIDENCE OF A BIOINDUCTIVE FGF-2 DEPENDENT MECHANISM Canadian Journal of Cardiology. 32: S81-S82. DOI: 10.1016/J.Cjca.2016.07.106  0.353
2015 Teng G, Svystonyuk D, Mewhort HE, Turnbull JD, Belke DD, Duff HJ, Fedak PW. Tetrandrine reverses human cardiac myofibroblast activation and myocardial fibrosis. American Journal of Physiology. Heart and Circulatory Physiology. 308: H1564-74. PMID 25862829 DOI: 10.1016/J.Cjca.2014.07.159  0.355
2015 Svystonyuk D, Malik G, Mewhort H, Guzzardi D, Park D, Belke D, Teng G, Fedak P. SIS-ECM BIOMATERIAL DECREASES HUMAN CARDIAC MYOFIBROBLAST ACTIVATION AND ATTENUATES LOCAL MATRIX REMODELING Canadian Journal of Cardiology. 31: S194-S195. DOI: 10.1016/J.Cjca.2015.07.412  0.347
2015 Mewhort H, Turnbull J, Teng G, Belke D, Svystonyuk D, Guzzardi D, Duff H, Fedak P. SURGICAL APPLICATION OF A NOVEL BIOMATERIAL ENHANCES POST-MI FUNCTIONAL RECOVERY BY STIMULATING VASCULOGENESIS THROUGH AN ACTIVE BIO-INDUCTIVE MECHANISM Canadian Journal of Cardiology. 31: S74. DOI: 10.1016/J.Cjca.2015.07.168  0.393
2014 Teo KK, Cohen E, Buller C, Hassan A, Carere R, Cox JL, Ly H, Fedak PW, Chan K, Légaré JF, Connelly K, Tanguay JF, Ye J, Gupta M, John Mancini GB, et al. Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology/Canadian Society of Cardiac Surgery position statement on revascularization--multivessel coronary artery disease. The Canadian Journal of Cardiology. 30: 1482-91. PMID 25475448 DOI: 10.1016/J.Cjca.2014.09.034  0.302
2014 Bracey NA, Gershkovich B, Chun J, Vilaysane A, Meijndert HC, Wright JR, Fedak PW, Beck PL, Muruve DA, Duff HJ. Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome. The Journal of Biological Chemistry. 289: 19571-84. PMID 24841199 DOI: 10.1074/Jbc.M114.550624  0.331
2014 Mewhort H, Turnbull J, Flewitt J, Meijndert H, Guzzardi D, Lipon B, Svystonyuk D, Fedak P. EXTRACELLULAR MATRIX PATCH THERAPY TO ENHANCE INFARCT HEALING: PRECLINICAL VALIDATION OF A NOVEL SURGICAL STRATEGY Canadian Journal of Cardiology. 30: S252-S253. DOI: 10.1016/J.Cjca.2014.07.437  0.308
2014 Mewhort H, Lipon B, Svystonyuk D, Guzzardi D, Fedak P. INFLAMMATION INDUCES POST-ISCHEMIC HEART FAILURE: SYSTEMIC MONOCYTES STIMULATE HUMAN CARDIAC MYOFIBROBLAST ACTIVATION BY DIRECT CELL-CELL CONTACT Canadian Journal of Cardiology. 30: S155. DOI: 10.1016/J.Cjca.2014.07.231  0.321
2014 Svystonyuk D, Ngu J, Mewhort H, Guzzardi D, Lipon B, Park D, Teng G, Belke D, Fedak P. FIBROBLAST GROWTH FACTOR (FGF-2) PREVENTS HUMAN CARDIAC FIBROBLAST-MEDIATED EXTRACELLULAR MATRIX REMODELING Canadian Journal of Cardiology. 30: S153. DOI: 10.1016/J.Cjca.2014.07.227  0.336
2013 Ngu J, Meijndert C, Mewhort H, Turnbull J, Yong W, Stetler-Stevenson W, Fedak P. The Role of Tissue Inhibitor of Metalloproteinase-2 in Human Cardiac Fibroblast-Mediated Extracellular Matrix Remodeling Canadian Journal of Cardiology. 29: S363-S364. DOI: 10.1016/J.Cjca.2013.07.622  0.374
2013 Mewhort H, Turnbull J, Meijndert C, Ngu J, Fedak P. Epicardial Infarct Repair Attenuates Ischemic Remodeling and Heart Failure Canadian Journal of Cardiology. 29: S212-S213. DOI: 10.1016/J.Cjca.2013.07.348  0.358
2012 Fedak PW, Bai L, Turnbull J, Ngu J, Narine K, Duff HJ. Cell therapy limits myofibroblast differentiation and structural cardiac remodeling: basic fibroblast growth factor-mediated paracrine mechanism. Circulation. Heart Failure. 5: 349-56. PMID 22508775 DOI: 10.1161/CIRCHEARTFAILURE.111.965889  0.305
2011 Deuse T, Adam M, Fedak P, Robbins R, Reichenspurner H, Schrepfer S. 546 Stem Cell Transplantation: HGF or VEGF Enhance Myocardial Function after Infarction The Journal of Heart and Lung Transplantation. 30: S183-S184. DOI: 10.1016/J.Healun.2011.01.557  0.37
2010 Deuse T, Fedak P, Robbins R, Reichenspurner H, Schrepfer S. 237: HGF or VEGF Gene Transfer Maximizes Mesenchymal Stem Cell-Based Myocardial Salvage after Acute Myocardial Infarction The Journal of Heart and Lung Transplantation. 29: S81-S81. DOI: 10.1016/J.Healun.2009.11.248  0.33
2009 Angoulvant D, Fazel S, Weisel RD, Lai TY, Fedak PW, Chen L, Rafati S, Seneviratne CK, Degousee N, Li RK. Cell-based gene therapy modifies matrix remodeling after a myocardial infarction in tissue inhibitor of matrix metalloproteinase-3-deficient mice. The Journal of Thoracic and Cardiovascular Surgery. 137: 471-80. PMID 19185172 DOI: 10.1016/J.Jtcvs.2008.08.031  0.569
2008 Fedak PW. Paracrine effects of cell transplantation: modifying ventricular remodeling in the failing heart. Seminars in Thoracic and Cardiovascular Surgery. 20: 87-93. PMID 18707639 DOI: 10.1053/j.semtcvs.2008.04.001  0.327
2007 Tian H, Cimini M, Fedak PW, Altamentova S, Fazel S, Huang ML, Weisel RD, Li RK. TIMP-3 deficiency accelerates cardiac remodeling after myocardial infarction. Journal of Molecular and Cellular Cardiology. 43: 733-43. PMID 17945252 DOI: 10.1016/J.Yjmcc.2007.09.003  0.533
2006 Wang CH, Anderson N, Li SH, Szmitko PE, Cherng WJ, Fedak PW, Fazel S, Li RK, Yau TM, Weisel RD, Stanford WL, Verma S. Stem cell factor deficiency is vasculoprotective: unraveling a new therapeutic potential of imatinib mesylate. Circulation Research. 99: 617-25. PMID 16931795 DOI: 10.1161/01.Res.0000243210.79654.Fd  0.51
2006 Fazel S, Cimini M, Chen L, Li S, Angoulvant D, Fedak P, Verma S, Weisel RD, Keating A, Li RK. Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. The Journal of Clinical Investigation. 116: 1865-77. PMID 16823487 DOI: 10.1172/Jci27019  0.576
2006 Fedak PW, Moravec CS, McCarthy PM, Altamentova SM, Wong AP, Skrtic M, Verma S, Weisel RD, Li RK. Altered expression of disintegrin metalloproteinases and their inhibitor in human dilated cardiomyopathy. Circulation. 113: 238-45. PMID 16401770 DOI: 10.1161/CIRCULATIONAHA.105.571414  0.518
2005 Fedak PW, Szmitko PE, Weisel RD, Altamentova SM, Nili N, Ohno N, Verma S, Fazel S, Strauss BH, Li RK. Cell transplantation preserves matrix homeostasis: a novel paracrine mechanism. The Journal of Thoracic and Cardiovascular Surgery. 130: 1430-9. PMID 16256799 DOI: 10.1016/J.Jtcvs.2005.05.055  0.532
2005 Fazel S, Chen L, Weisel RD, Angoulvant D, Seneviratne C, Fazel A, Cheung P, Lam J, Fedak PW, Yau TM, Li RK. Cell transplantation preserves cardiac function after infarction by infarct stabilization: augmentation by stem cell factor. The Journal of Thoracic and Cardiovascular Surgery. 130: 1310. PMID 16256783 DOI: 10.1016/J.Jtcvs.2005.07.012  0.511
2005 Fedak PW, Verma S, Weisel RD, Skrtic M, Li RK. Cardiac remodeling and failure: from molecules to man (Part III). Cardiovascular Pathology : the Official Journal of the Society For Cardiovascular Pathology. 14: 109-19. PMID 15914295 DOI: 10.1016/j.carpath.2005.03.004  0.541
2005 Fedak PW, Verma S, Weisel RD, Li RK. Cardiac remodeling and failure From molecules to man (Part II). Cardiovascular Pathology : the Official Journal of the Society For Cardiovascular Pathology. 14: 49-60. PMID 15780796 DOI: 10.1016/j.carpath.2005.01.005  0.553
2005 Wang CH, Li SH, Weisel RD, Fedak PW, Hung A, Li RK, Rao V, Hyland K, Cherng WJ, Errett L, Leclerc Y, Bonneau D, Latter DA, Verma S. Tetrahydrobiopterin deficiency exaggerates intimal hyperplasia after vascular injury. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 289: R299-304. PMID 15774769 DOI: 10.1152/ajpregu.00269.2004  0.481
2005 Fedak PW, Verma S, Weisel RD, Li RK. Cardiac remodeling and failure: from molecules to man (Part I). Cardiovascular Pathology : the Official Journal of the Society For Cardiovascular Pathology. 14: 1-11. PMID 15710285 DOI: 10.1016/J.Carpath.2004.12.002  0.529
2004 Weisel RD, Fazel S, Fedak PW, Li RK. Cardiac restoration by cell transplantation. International Journal of Cardiology. 95: S5-7. PMID 15336835  0.516
2004 Liu TB, Fedak PW, Weisel RD, Yasuda T, Kiani G, Mickle DA, Jia ZQ, Li RK. Enhanced IGF-1 expression improves smooth muscle cell engraftment after cell transplantation. American Journal of Physiology. Heart and Circulatory Physiology. 287: H2840-9. PMID 15331370 DOI: 10.1152/ajpheart.00439.2004  0.505
2004 Fedak PW, Smookler DS, Kassiri Z, Ohno N, Leco KJ, Verma S, Mickle DA, Watson KL, Hojilla CV, Cruz W, Weisel RD, Li RK, Khokha R. TIMP-3 deficiency leads to dilated cardiomyopathy. Circulation. 110: 2401-9. PMID 15262835 DOI: 10.1161/01.Cir.0000134959.83967.2D  0.545
2004 Ozawa T, Mickle DA, Weisel RD, Matsubayashi K, Fujii T, Fedak PW, Koyama N, Ikada Y, Li RK. Tissue-engineered grafts matured in the right ventricular outflow tract. Cell Transplantation. 13: 169-77. PMID 15129763  0.473
2004 Verma S, Rao V, Weisel RD, Li SH, Fedak PW, Miriuka S, Li RK. Novel cardioprotective effects of pravastatin in human ventricular cardiomyocytes subjected to hypoxia and reoxygenation: beneficial effects of statins independent of endothelial cells. The Journal of Surgical Research. 119: 66-71. PMID 15126084 DOI: 10.1016/J.Jss.2003.10.011  0.565
2004 Wang CH, Ciliberti N, Li SH, Szmitko PE, Weisel RD, Fedak PW, Al-Omran M, Cherng WJ, Li RK, Stanford WL, Verma S. Rosiglitazone facilitates angiogenic progenitor cell differentiation toward endothelial lineage: a new paradigm in glitazone pleiotropy. Circulation. 109: 1392-400. PMID 14993120 DOI: 10.1161/01.Cir.0000123231.49594.21  0.495
2004 Li SH, Szmitko PE, Weisel RD, Wang CH, Fedak PW, Li RK, Mickle DA, Verma S. C-reactive protein upregulates complement-inhibitory factors in endothelial cells. Circulation. 109: 833-6. PMID 14967730 DOI: 10.1161/01.CIR.0000117087.27524.0E  0.504
2003 Mikhail P, Verma S, Fedak PW, Weisel RD, Li RK. Does ischemic preconditioning afford clinically relevant cardioprotection? American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions. 3: 1-11. PMID 14727941  0.482
2003 Verma S, Badiwala MV, Weisel RD, Li SH, Wang CH, Fedak PW, Li RK, Mickle DA. C-reactive protein activates the nuclear factor-kappaB signal transduction pathway in saphenous vein endothelial cells: implications for atherosclerosis and restenosis. The Journal of Thoracic and Cardiovascular Surgery. 126: 1886-91. PMID 14688701 DOI: 10.1016/J.Jtcvs.2003.07.026  0.489
2003 Ohno N, Fedak PW, Weisel RD, Mickle DA, Fujii T, Li RK. Transplantation of cryopreserved muscle cells in dilated cardiomyopathy: effects on left ventricular geometry and function. The Journal of Thoracic and Cardiovascular Surgery. 126: 1537-48. PMID 14666030 DOI: 10.1016/S0022-5223(03)01021-3  0.521
2003 Fedak PW, Weisel RD, Verma S, Mickle DA, Li RK. Restoration and regeneration of failing myocardium with cell transplantation and tissue engineering. Seminars in Thoracic and Cardiovascular Surgery. 15: 277-86. PMID 12973705 DOI: 10.1016/S1043-0679(03)70007-0  0.568
2003 Matsubayashi K, Fedak PW, Mickle DA, Weisel RD, Ozawa T, Li RK. Improved left ventricular aneurysm repair with bioengineered vascular smooth muscle grafts. Circulation. 108: II219-25. PMID 12970236 DOI: 10.1161/01.cir.0000087450.34497.9a  0.489
2003 Verma S, Li SH, Wang CH, Fedak PW, Li RK, Weisel RD, Mickle DA. Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction. Circulation. 108: 736-40. PMID 12874180 DOI: 10.1161/01.Cir.0000084503.91330.49  0.466
2003 Dhillon B, Badiwala MV, Li SH, Li RK, Weisel RD, Mickle DA, Fedak PW, Rao V, Verma S. Caveolin: a key target for modulating nitric oxide availability in health and disease. Molecular and Cellular Biochemistry. 247: 101-9. PMID 12841637 DOI: 10.1023/A:1024198518582  0.471
2003 Tang GH, Fedak PW, Yau TM, Weisel RD, Kulik A, Mickle DA, Li RK. Cell transplantation to improve ventricular function in the failing heart. European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association For Cardio-Thoracic Surgery. 23: 907-16. PMID 12829066 DOI: 10.1016/S1010-7940(03)00140-4  0.529
2003 Verma S, Wang CH, Weisel RD, Badiwala MV, Li SH, Fedak PW, Li RK, Mickle DA. Hyperglycemia potentiates the proatherogenic effects of C-reactive protein: reversal with rosiglitazone. Journal of Molecular and Cellular Cardiology. 35: 417-9. PMID 12689821 DOI: 10.1016/S0022-2828(03)00042-7  0.512
2003 Wang CH, Li SH, Weisel RD, Fedak PW, Dumont AS, Szmitko P, Li RK, Mickle DA, Verma S. C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle. Circulation. 107: 1783-90. PMID 12665485 DOI: 10.1161/01.Cir.0000061916.95736.E5  0.491
2003 Fedak PW, Altamentova SM, Weisel RD, Nili N, Ohno N, Verma S, Lee TY, Kiani C, Mickle DA, Strauss BH, Li RK. Matrix remodeling in experimental and human heart failure: a possible regulatory role for TIMP-3. American Journal of Physiology. Heart and Circulatory Physiology. 284: H626-34. PMID 12388270 DOI: 10.1152/Ajpheart.00684.2002  0.515
2003 Verma S, Badiwala MV, Wang CH, Weisel RD, Li S, Bikramjit D, Fedak PW, Li R, Mickle DA. C-reactive protein activates the NF-κB signal transduction pathway in human saphenous vein endothelial cells Journal of the American College of Cardiology. 41: 318. DOI: 10.1016/S0735-1097(03)82487-7  0.313
2002 Ohno N, Fedak PW, Weisel RD, Komeda M, Mickle DA, Li RK. Cell transplantation in non-ischemic dilated cardiomyopathy. A novel biological approach for ventricular restoration. The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association For Thoracic Surgery = Nihon KyōBu Geka Gakkai Zasshi. 50: 457-60. PMID 12478864 DOI: 10.1007/Bf02919635  0.488
2002 Akhyari P, Fedak PW, Weisel RD, Lee TY, Verma S, Mickle DA, Li RK. Mechanical stretch regimen enhances the formation of bioengineered autologous cardiac muscle grafts. Circulation. 106: I137-42. PMID 12354723 DOI: 10.1161/01.Cir.0000032893.55215.Fc  0.513
2002 Verma S, Wang CH, Li SH, Dumont AS, Fedak PW, Badiwala MV, Dhillon B, Weisel RD, Li RK, Mickle DA, Stewart DJ. A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation. 106: 913-9. PMID 12186793 DOI: 10.1161/01.Cir.0000029802.88087.5E  0.447
2002 Verma S, Maitland A, Weisel RD, Li SH, Fedak PW, Pomroy NC, Mickle DA, Li RK, Ko L, Rao V. Hyperglycemia exaggerates ischemia-reperfusion-induced cardiomyocyte injury: reversal with endothelin antagonism. The Journal of Thoracic and Cardiovascular Surgery. 123: 1120-4. PMID 12063458 DOI: 10.1067/Mtc.2002.121973  0.468
2002 Verma S, Maitland A, Weisel RD, Fedak PW, Li SH, Mickle DA, Li RK, Ko L, Rao V. Increased endothelin-1 production in diabetic patients after cardioplegic arrest and reperfusion impairs coronary vascular reactivity: reversal by means of endothelin antagonism. The Journal of Thoracic and Cardiovascular Surgery. 123: 1114-9. PMID 12063457 DOI: 10.1067/Mtc.2002.121972  0.467
2002 Verma S, Maitland A, Weisel RD, Fedak PW, Pomroy NC, Li SH, Mickle DA, Li RK, Rao V. Novel cardioprotective effects of tetrahydrobiopterin after anoxia and reoxygenation: Identifying cellular targets for pharmacologic manipulation. The Journal of Thoracic and Cardiovascular Surgery. 123: 1074-83. PMID 12063453 DOI: 10.1067/Mtc.2002.121687  0.538
2002 Verma S, Fedak PW, Weisel RD, Butany J, Rao V, Maitland A, Li RK, Dhillon B, Yau TM. Fundamentals of reperfusion injury for the clinical cardiologist. Circulation. 105: 2332-6. PMID 12021216 DOI: 10.1161/01.Cir.0000016602.96363.36  0.486
2002 Verma S, Li SH, Badiwala MV, Weisel RD, Fedak PW, Li RK, Dhillon B, Mickle DA. Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein. Circulation. 105: 1890-6. PMID 11997273 DOI: 10.1161/01.Cir.0000015126.83143.B4  0.446
2002 Shiono N, Rao V, Weisel RD, Kawasaki M, Li RK, Mickle DA, Fedak PW, Tumiati LC, Ko L, Verma S. L-arginine protects human heart cells from low-volume anoxia and reoxygenation. American Journal of Physiology. Heart and Circulatory Physiology. 282: H805-15. PMID 11834473 DOI: 10.1152/ajpheart.00594.2001  0.494
2002 Miriuka S, Rao V, Weisel R, Li S, Anderson T, Maitland A, Fedak P, Li R, Verma S. Cyclosporin induced endothelial dysfunction: effects of the nitric oxide cofactor, tetrahydrobiopterin The Journal of Heart and Lung Transplantation. 21: 130-131. DOI: 10.1016/S1053-2498(01)00644-1  0.461
2002 Verma S, Shiono N, Li R, Mickle DA, Fedak PW, Weisel RD. L-arginine protects human heart cells from simulated anoxia and reoxgenation Journal of the American College of Cardiology. 39: 451-452. DOI: 10.1016/S0735-1097(02)82029-0  0.324
Show low-probability matches.