| Year |
Citation |
Score |
| 2022 |
Schaefer K, Lui I, Byrnes JR, Kang E, Zhou J, Weeks AM, Wells JA. Direct Identification of Proteolytic Cleavages on Living Cells Using a Glycan-Tethered Peptide Ligase. Acs Central Science. 8: 1447-1456. PMID 36313159 DOI: 10.1021/acscentsci.2c00899 |
0.567 |
|
| 2022 |
Jiang Z, Kuo YH, Zhong M, Zhang J, Zhou XX, Xing L, Wells JA, Wang Y, Arkin MR. Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein-Protein Interactions. Journal of the American Chemical Society. PMID 35819848 DOI: 10.1021/jacs.2c03665 |
0.732 |
|
| 2022 |
Byrnes JR, Weeks AM, Shifrut E, Carnevale J, Kirkemo L, Ashworth A, Marson A, Wells JA. Hypoxia is a dominant remodeler of the effector T cell surface proteome relative to activation and regulatory T cell suppression. Molecular & Cellular Proteomics : McP. 100217. PMID 35217172 DOI: 10.1016/j.mcpro.2022.100217 |
0.5 |
|
| 2022 |
Martinko AJ, Simonds EF, Prasad S, Ponce A, Bracken CJ, Wei J, Wang YH, Chow TL, Huang Z, Evans MJ, Wells JA, Hill ZB. Switchable assembly and function of antibody complexes in vivo using a small molecule. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35210365 DOI: 10.1073/pnas.2117402119 |
0.737 |
|
| 2021 |
Weeks AM, Byrnes JR, Lui I, Wells JA. Mapping proteolytic neo-N termini at the surface of living cells. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33536314 DOI: 10.1073/pnas.2018809118 |
0.513 |
|
| 2021 |
Chen W, Mou KY, Solomon P, Aggarwal R, Leung KK, Wells JA. Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33483421 DOI: 10.1073/pnas.2018861118 |
0.545 |
|
| 2020 |
Lim SA, Wells JA. Split enzymes: Design principles and strategy. Methods in Enzymology. 644: 275-296. PMID 32943149 DOI: 10.1016/Bs.Mie.2020.05.001 |
0.33 |
|
| 2020 |
Zhou X, Bracken C, Zhang K, Zhou J, Mou KY, Wang L, Cheng Y, Leung KKK, Wells JA. Targeting phosphotyrosine in native proteins with conditional, bi-specific antibody traps. Journal of the American Chemical Society. PMID 32924468 DOI: 10.1021/Jacs.0C08458 |
0.373 |
|
| 2020 |
Lim DC, Joukov V, Rettenmaier TJ, Kumagai A, Dunphy WG, Wells JA, Yaffe MB. Redox priming promotes Aurora A activation during mitosis. Science Signaling. 13. PMID 32694171 DOI: 10.1126/Scisignal.Abb6707 |
0.364 |
|
| 2020 |
Harvey EP, Hauseman ZJ, Cohen DT, Rettenmaier TJ, Lee S, Huhn AJ, Wales TE, Seo HS, Luccarelli J, Newman CE, Guerra RM, Bird GH, Dhe-Paganon S, Engen JR, Wells JA, et al. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chemical Biology. PMID 32413285 DOI: 10.1016/J.Chembiol.2020.04.004 |
0.392 |
|
| 2020 |
Leung KK, Wilson GM, Kirkemo LL, Riley NM, Coon JJ, Wells JA. Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes. Proceedings of the National Academy of Sciences of the United States of America. PMID 32205440 DOI: 10.1073/Pnas.1917947117 |
0.359 |
|
| 2020 |
Elledge SK, Tran HL, Christian AH, Steri V, Hann B, Toste FD, Chang CJ, Wells JA. Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation. Proceedings of the National Academy of Sciences of the United States of America. PMID 32123103 DOI: 10.1073/Pnas.1920561117 |
0.345 |
|
| 2020 |
Weeks AM, Wells JA. N-Terminal Modification of Proteins with Subtiligase Specificity Variants. Current Protocols in Chemical Biology. 12: e79. PMID 32074409 DOI: 10.1002/Cpch.79 |
0.608 |
|
| 2019 |
Wei J, Leung K, Truillet C, Ruggero D, Wells J, Evans MJ. Profiling the surfaceome identifies therapeutic targets for cells with hyperactive mTORC1 signaling. Molecular & Cellular Proteomics : McP. PMID 31792071 DOI: 10.1074/Mcp.Ra119.001785 |
0.321 |
|
| 2019 |
Weeks AM, Wells JA. Subtiligase-Catalyzed Peptide Ligation. Chemical Reviews. PMID 31663725 DOI: 10.1021/Acs.Chemrev.9B00372 |
0.579 |
|
| 2019 |
Yueh C, Rettenmaier J, Xia B, Hall DR, Alekseenko A, Porter KA, Barkovich K, Keseru G, Whitty A, Wells JA, Vajda S, Kozakov D. Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases. Journal of Medicinal Chemistry. PMID 31274316 DOI: 10.1021/Acs.Jmedchem.9B00089 |
0.311 |
|
| 2019 |
Hertz NT, Adams EL, Weber RA, Shen RJ, O'Rourke MK, Simon DJ, Zebroski H, Olsen O, Morgan CW, Mileur TR, Hitchcock AM, Sinnott Armstrong NA, Wainberg M, Bassik MC, Molina H, ... Wells JA, et al. Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration. Neuron. PMID 31221560 DOI: 10.1016/J.Neuron.2019.05.030 |
0.711 |
|
| 2018 |
Mou Y, Zhou X, Leung K, Martinko AJ, Yu JY, Chen W, Wells JA. Engineering improved anti-phosphotyrosine antibodies based on immuno-convergent binding motif. Journal of the American Chemical Society. PMID 30398859 DOI: 10.1021/jacs.8b08402 |
0.552 |
|
| 2018 |
Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks CL, Fierke CA, Mapp AK. Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators. Proceedings of the National Academy of Sciences of the United States of America. PMID 30127017 DOI: 10.1073/Pnas.1806202115 |
0.766 |
|
| 2018 |
Keedy DA, Hill ZB, Biel JT, Kang E, Rettenmaier TJ, Brandao-Neto J, Pearce NM, von Delft F, Wells JA, Fraser JS. An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife. 7. PMID 29877794 DOI: 10.7554/Elife.36307 |
0.784 |
|
| 2018 |
Spangler B, Kline T, Hanson J, Li X, Zhou S, Wells JA, Sato AK, Renslo AR. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Molecular Pharmaceutics. PMID 29569925 DOI: 10.1021/Acs.Molpharmaceut.8B00242 |
0.336 |
|
| 2018 |
Pollock SB, Hu A, Mou Y, Martinko AJ, Julien O, Hornsby M, Ploder L, Adams JJ, Geng H, Müschen M, Sidhu SS, Moffat J, Wells JA. Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies. Proceedings of the National Academy of Sciences of the United States of America. PMID 29476010 DOI: 10.1073/Pnas.1721899115 |
0.332 |
|
| 2018 |
Martinko AJ, Truillet C, Julien O, Diaz J, Horlbeck MA, Whiteley G, Blonder J, Weissman JS, Bandyopadhyay S, Evans M, Wells JA. Targeting RAS driven human cancer cells with antibodies to upregulated and essential cell-surface proteins. Elife. 7. PMID 29359686 DOI: 10.7554/Elife.31098 |
0.611 |
|
| 2018 |
Keedy DA, Hill ZB, Biel JT, Kang E, Rettenmaier TJ, Brandão-Neto J, Pearce NM, Delft Fv, Wells JA, Fraser JS. Author response: An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering Elife. DOI: 10.7554/Elife.36307.045 |
0.719 |
|
| 2018 |
Mou Y, Zhou XX, Leung K, Martinko AJ, Yu J, Chen W, Wells JA. Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif. Journal of the American Chemical Society. 140: 16615-16624. DOI: 10.2210/Pdb6Dez/Pdb |
0.587 |
|
| 2018 |
Litvinov RI, Fong KPY, Kim OV, Molnar KI, Billings PC, Sternisha A, Wells JA, Weisel JW, DeGrado WF, Bennett JS. Active Calpain Promotes Fibrin Clot Contraction By Strengthening the Coupling of Fibrin-Bound αIIbβ3 to the Platelet Cytoskeleton Blood. 132: 1128-1128. DOI: 10.1182/Blood-2018-99-113063 |
0.347 |
|
| 2017 |
Hill ZB, Martinko AJ, Nguyen DP, Wells JA. Human antibody-based chemically induced dimerizers for cell therapeutic applications. Nature Chemical Biology. PMID 29200207 DOI: 10.1038/Nchembio.2529 |
0.765 |
|
| 2017 |
Weeks AM, Wells JA. Engineering peptide ligase specificity by proteomic identification of ligation sites. Nature Chemical Biology. PMID 29155430 DOI: 10.1038/Nchembio.2521 |
0.605 |
|
| 2017 |
Srinivasan SR, Cesa LC, Li X, Julien O, Zhuang M, Shao H, Chung J, Maillard I, Wells JA, Duckett C, Gestwicki JE. Heat Shock Protein 70 (Hsp70) Suppresses RIP1-dependent Apoptotic and Necroptotic Cascades. Molecular Cancer Research : McR. PMID 28970360 DOI: 10.1158/1541-7786.Mcr-17-0408 |
0.318 |
|
| 2017 |
Diaz JE, Morgan CW, Minogue CE, Hebert AS, Coon JJ, Wells JA. A Split-Abl Kinase for Direct Activation in Cells. Cell Chemical Biology. PMID 28919041 DOI: 10.1016/J.Chembiol.2017.08.007 |
0.789 |
|
| 2017 |
Smart AD, Pache RA, Thomsen ND, Kortemme T, Davis GW, Wells JA. Engineering a light-activated caspase-3 for precise ablation of neurons in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 28893998 DOI: 10.1073/Pnas.1705064114 |
0.325 |
|
| 2017 |
Julien O, Wells JA. Caspases and their substrates. Cell Death and Differentiation. PMID 28498362 DOI: 10.1038/Cdd.2017.44 |
0.364 |
|
| 2017 |
Lin S, Yang X, Jia S, Weeks AM, Hornsby M, Lee PS, Nichiporuk RV, Iavarone AT, Wells JA, Toste FD, Chang CJ. Redox-based reagents for chemoselective methionine bioconjugation. Science (New York, N.Y.). 355: 597-602. PMID 28183972 DOI: 10.1126/Science.Aal3316 |
0.583 |
|
| 2017 |
Tran HL, Lexa KW, Julien O, Young TS, Walsh CT, Jacobson MP, Wells JA. SAR and molecular mechanics reveal the importance of ring entropy in the biosynthesis and activity of a natural product. Journal of the American Chemical Society. PMID 28170244 DOI: 10.1021/Jacs.6B10792 |
0.361 |
|
| 2017 |
Calvo SE, Julien O, Clauser KR, Shen H, Kamer KJ, Wells JA, Mootha VK. Comparative analysis of mitochondrial N-termini from mouse, human, and yeast. Molecular & Cellular Proteomics : McP. PMID 28122942 DOI: 10.1074/Mcp.M116.063818 |
0.321 |
|
| 2016 |
Ye X, Chan KC, Waters AM, Bess M, Harned A, Wei BR, Loncarek J, Luke BT, Orsburn BC, Hollinger BD, Stephens RM, Bagni R, Martinko A, Wells JA, Nissley DV, et al. Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface. Oncotarget. PMID 27894102 DOI: 10.18632/Oncotarget.13566 |
0.303 |
|
| 2016 |
Henager SH, Chu N, Chen Z, Bolduc D, Dempsey DR, Hwang Y, Wells J, Cole PA. Enzyme-catalyzed expressed protein ligation. Nature Methods. PMID 27669326 DOI: 10.1038/Nmeth.4004 |
0.334 |
|
| 2016 |
Hill ZB, Pollock SB, Zhuang M, Wells JA. Direct proximity tagging of small molecule protein targets using an engineered NEDD8 ligase. Journal of the American Chemical Society. PMID 27626304 DOI: 10.1021/Jacs.6B06828 |
0.774 |
|
| 2016 |
Wang W, Nguyen LT, Burlak C, Chegini F, Guo F, Chataway T, Ju S, Fisher OS, Miller DW, Datta D, Wu F, Wu CX, Landeru A, Wells JA, Cookson MR, et al. Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein. Proceedings of the National Academy of Sciences of the United States of America. PMID 27482083 DOI: 10.1073/Pnas.1610099113 |
0.526 |
|
| 2016 |
Spangler B, Morgan CW, Fontaine SD, Vander Wal MN, Chang CJ, Wells JA, Renslo AR. A reactivity-based probe of the intracellular labile ferrous iron pool. Nature Chemical Biology. PMID 27376690 DOI: 10.1038/Nchembio.2116 |
0.702 |
|
| 2016 |
Seaman JE, Julien O, Lee PS, Rettenmaier TJ, Thomsen ND, Wells JA. Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues. Cell Death and Differentiation. PMID 27367566 DOI: 10.1038/Cdd.2016.62 |
0.384 |
|
| 2016 |
Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA. Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity. Nature Communications. 7: 12009. PMID 27363581 DOI: 10.1038/Ncomms12009 |
0.329 |
|
| 2016 |
Hill ME, MacPherson DJ, Wu P, Julien O, Wells JA, Hardy JA. Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chemical Biology. PMID 27032039 DOI: 10.1021/Acschembio.5B00971 |
0.409 |
|
| 2016 |
Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Proceedings of the National Academy of Sciences of the United States of America. PMID 27006500 DOI: 10.1073/Pnas.1524900113 |
0.387 |
|
| 2016 |
Cimermancic P, Weinkam P, Rettenmaier TJ, Bichmann L, Keedy DA, Woldeyes RA, Schneidmann D, Demerdash ON, Mitchell JC, Wells JA, Fraser JS, Sali A. CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites. Journal of Molecular Biology. PMID 26854760 DOI: 10.1016/J.Jmb.2016.01.029 |
0.356 |
|
| 2015 |
Rettenmaier TJ, Fan H, Karpiak J, Doak A, Sali A, Shoichet BK, Wells JA. Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking. Journal of Medicinal Chemistry. 58: 8285-91. PMID 26443011 DOI: 10.1021/Acs.Jmedchem.5B01216 |
0.356 |
|
| 2015 |
Hornsby M, Paduch M, Miersch S, Sääf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K, Lu V, Thomas W, Luke J, Goodman J, ... ... Wells J, et al. A High Through-put Platform for Recombinant Antibodies to Folded Proteins. Molecular & Cellular Proteomics : McP. PMID 26290498 DOI: 10.1074/Mcp.O115.052209 |
0.313 |
|
| 2015 |
Morgan CW, Diaz JE, Zeitlin SG, Gray DC, Wells JA. Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling. Proceedings of the National Academy of Sciences of the United States of America. PMID 26106156 DOI: 10.1073/Pnas.1504141112 |
0.783 |
|
| 2015 |
Miersch S, Li Z, Hanna R, McLaughlin ME, Hornsby M, Matsuguchi T, Paduch M, Sääf A, Wells J, Koide S, Kossiakoff A, Sidhu SS. Scalable high throughput selection from phage-displayed synthetic antibody libraries. Journal of Visualized Experiments : Jove. 51492. PMID 25651360 DOI: 10.3791/51492 |
0.301 |
|
| 2015 |
Koerber JT, Hornsby MJ, Wells JA. An improved single-chain Fab platform for efficient display and recombinant expression. Journal of Molecular Biology. 427: 576-86. PMID 25481745 DOI: 10.1016/J.Jmb.2014.11.017 |
0.307 |
|
| 2014 |
Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proceedings of the National Academy of Sciences of the United States of America. 111: 18590-5. PMID 25518860 DOI: 10.1073/Pnas.1415365112 |
0.647 |
|
| 2014 |
Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. Unraveling the mechanism of cell death induced by chemical fibrils. Nature Chemical Biology. 10: 969-76. PMID 25262416 DOI: 10.1038/Nchembio.1639 |
0.746 |
|
| 2014 |
Arkin MR, Tang Y, Wells JA. Small-molecule inhibitors of protein-protein interactions: progressing toward the reality. Chemistry & Biology. 21: 1102-14. PMID 25237857 DOI: 10.1016/J.Chembiol.2014.09.001 |
0.674 |
|
| 2014 |
Wiita AP, Seaman JE, Wells JA. Global analysis of cellular proteolysis by selective enzymatic labeling of protein N-termini. Methods in Enzymology. 544: 327-58. PMID 24974296 DOI: 10.1016/B978-0-12-417158-9.00013-3 |
0.398 |
|
| 2014 |
Morgan CW, Julien O, Unger EK, Shah NM, Wells JA. Turning on caspases with genetics and small molecules. Methods in Enzymology. 544: 179-213. PMID 24974291 DOI: 10.1016/B978-0-12-417158-9.00008-X |
0.752 |
|
| 2014 |
Wells JA, Kossiakoff AA. Cell biology. New tricks for an old dimer. Science (New York, N.Y.). 344: 703-4. PMID 24833381 DOI: 10.1126/Science.1254799 |
0.333 |
|
| 2014 |
Wiita AP, Hsu GW, Lu CM, Esensten JH, Wells JA. Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling. Proceedings of the National Academy of Sciences of the United States of America. 111: 7594-9. PMID 24821784 DOI: 10.1073/Pnas.1405987111 |
0.355 |
|
| 2014 |
Lodge JM, Rettenmaier TJ, Wells JA, Pomerantz WC, Mapp AK. FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions. Medchemcomm. 5: 370-375. PMID 24795804 DOI: 10.1039/C3Md00356F |
0.374 |
|
| 2014 |
Keedy D, van den Bedem H, Rettenmaier J, Wells J, Fraser J. Discovering and Manipulating Protein Conformational Heterogeneity and Function Biophysical Journal. 106: 635a-636a. DOI: 10.1016/J.Bpj.2013.11.3515 |
0.327 |
|
| 2014 |
Julien O, Kampmann M, Bassik MC, Venditto VJ, Zorn JA, Rheingold AL, Weissman JS, Wells JA. Unraveling the Mechanism of Cell Death Induced by Chemical and Protein Fibrils Biophysical Journal. 106: 40a. DOI: 10.1016/J.Bpj.2013.11.297 |
0.753 |
|
| 2013 |
Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 503: 548-51. PMID 24256730 DOI: 10.1038/Nature12796 |
0.316 |
|
| 2013 |
Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. Global cellular response to chemotherapy-induced apoptosis. Elife. 2: e01236. PMID 24171104 DOI: 10.7554/Elife.01236 |
0.336 |
|
| 2013 |
Koerber JT, Thomsen ND, Hannigan BT, Degrado WF, Wells JA. Nature-inspired design of motif-specific antibody scaffolds. Nature Biotechnology. 31: 916-21. PMID 23955275 DOI: 10.1038/Nbt.2672 |
0.318 |
|
| 2013 |
Yang CF, Chiang MC, Gray DC, Prabhakaran M, Alvarado M, Juntti SA, Unger EK, Wells JA, Shah NM. Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males. Cell. 153: 896-909. PMID 23663785 DOI: 10.1016/J.Cell.2013.04.017 |
0.579 |
|
| 2013 |
Thomsen ND, Koerber JT, Wells JA. Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proceedings of the National Academy of Sciences of the United States of America. 110: 8477-82. PMID 23650375 DOI: 10.1073/Pnas.1306759110 |
0.332 |
|
| 2013 |
Datta D, McClendon CL, Jacobson MP, Wells JA. Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3. The Journal of Biological Chemistry. 288: 9971-81. PMID 23386603 DOI: 10.1074/Jbc.M112.426460 |
0.799 |
|
| 2013 |
Wang N, Majmudar CY, Pomerantz WC, Gagnon JK, Sadowsky JD, Meagher JL, Johnson TK, Stuckey JA, Brooks CL, Wells JA, Mapp AK. Ordering a dynamic protein via a small-molecule stabilizer. Journal of the American Chemical Society. 135: 3363-6. PMID 23384013 DOI: 10.1021/Ja3122334 |
0.375 |
|
| 2013 |
Crawford ED, Seaman JE, Agard N, Hsu GW, Julien O, Mahrus S, Nguyen H, Shimbo K, Yoshihara HA, Zhuang M, Chalkley RJ, Wells JA. The DegraBase: a database of proteolysis in healthy and apoptotic human cells. Molecular & Cellular Proteomics : McP. 12: 813-24. PMID 23264352 DOI: 10.1074/Mcp.O112.024372 |
0.783 |
|
| 2013 |
Zhuang M, Guan S, Wang H, Burlingame AL, Wells JA. Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator. Molecular Cell. 49: 273-82. PMID 23201124 DOI: 10.1016/J.Molcel.2012.10.022 |
0.379 |
|
| 2013 |
Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. Abstract PL04-03: Selective inhibition of K-Ras G12C through allosteric control of GTP affinity and effector interactions. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-Pl04-03 |
0.316 |
|
| 2012 |
Crawford ED, Seaman JE, Barber AE, David DC, Babbitt PC, Burlingame AL, Wells JA. Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Cell Death and Differentiation. 19: 2040-8. PMID 22918439 DOI: 10.1038/Cdd.2012.99 |
0.626 |
|
| 2012 |
Zorn JA, Wolan DW, Agard NJ, Wells JA. Fibrils colocalize caspase-3 with procaspase-3 to foster maturation. The Journal of Biological Chemistry. 287: 33781-95. PMID 22872644 DOI: 10.1074/Jbc.M112.386128 |
0.79 |
|
| 2012 |
Shimbo K, Hsu GW, Nguyen H, Mahrus S, Trinidad JC, Burlingame AL, Wells JA. Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 109: 12432-7. PMID 22802652 DOI: 10.1073/Pnas.1208616109 |
0.321 |
|
| 2012 |
Agard NJ, Mahrus S, Trinidad JC, Lynn A, Burlingame AL, Wells JA. Global kinetic analysis of proteolysis via quantitative targeted proteomics. Proceedings of the National Academy of Sciences of the United States of America. 109: 1913-8. PMID 22308409 DOI: 10.1073/Pnas.1117158109 |
0.375 |
|
| 2012 |
Gao J, Wells JA. Identification of specific tethered inhibitors for caspase-5. Chemical Biology & Drug Design. 79: 209-15. PMID 22014003 DOI: 10.1111/J.1747-0285.2011.01261.X |
0.389 |
|
| 2012 |
Shuman M, Wells J, Shokat K, Bernales S, Walter P, Shultz L, Goodwin N. A quaternary equation for interdisciplinary medical research (IMR) Journal of Translational Medicine. 10. DOI: 10.1186/1479-5876-10-S2-A49 |
0.307 |
|
| 2011 |
Zorn JA, Wille H, Wolan DW, Wells JA. Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation. Journal of the American Chemical Society. 133: 19630-3. PMID 22066605 DOI: 10.1021/Ja208350U |
0.798 |
|
| 2011 |
Tang Y, Wells JA, Arkin MR. Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. The Journal of Biological Chemistry. 286: 34147-54. PMID 21828056 DOI: 10.1074/Jbc.M111.247627 |
0.692 |
|
| 2011 |
Crawford ED, Wells JA. Caspase substrates and cellular remodeling. Annual Review of Biochemistry. 80: 1055-87. PMID 21456965 DOI: 10.1146/Annurev-Biochem-061809-121639 |
0.6 |
|
| 2011 |
Sadowsky JD, Burlingame MA, Wolan DW, McClendon CL, Jacobson MP, Wells JA. Turning a protein kinase on or off from a single allosteric site via disulfide trapping. Proceedings of the National Academy of Sciences of the United States of America. 108: 6056-61. PMID 21430264 DOI: 10.1073/Pnas.1102376108 |
0.799 |
|
| 2011 |
Pérez-Payá E, Orzáez M, Mondragón L, Wolan D, Wells JA, Messeguer A, Vicent MJ. Molecules that modulate Apaf-1 activity. Medicinal Research Reviews. 31: 649-75. PMID 20099266 DOI: 10.1002/Med.20198 |
0.665 |
|
| 2011 |
Wells JA. Abstract SY08-02: Markers of caspase activation in cells and serum Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Sy08-02 |
0.343 |
|
| 2010 |
Gray DC, Mahrus S, Wells JA. Activation of specific apoptotic caspases with an engineered small-molecule-activated protease. Cell. 142: 637-46. PMID 20723762 DOI: 10.1016/J.Cell.2010.07.014 |
0.676 |
|
| 2010 |
Barkan DT, Hostetter DR, Mahrus S, Pieper U, Wells JA, Craik CS, Sali A. Prediction of protease substrates using sequence and structure features. Bioinformatics (Oxford, England). 26: 1714-22. PMID 20505003 DOI: 10.1093/Bioinformatics/Btq267 |
0.34 |
|
| 2010 |
Agard NJ, Maltby D, Wells JA. Inflammatory stimuli regulate caspase substrate profiles. Molecular & Cellular Proteomics : McP. 9: 880-93. PMID 20173201 DOI: 10.1074/Mcp.M900528-Mcp200 |
0.354 |
|
| 2010 |
Wildes D, Wells JA. Sampling the N-terminal proteome of human blood. Proceedings of the National Academy of Sciences of the United States of America. 107: 4561-6. PMID 20173099 DOI: 10.1073/Pnas.0914495107 |
0.331 |
|
| 2010 |
Zorn JA, Wells JA. Turning enzymes ON with small molecules. Nature Chemical Biology. 6: 179-188. PMID 20154666 DOI: 10.1038/Nchembio.318 |
0.749 |
|
| 2010 |
Estell DA, Graycar TP, Miller JV, Powers DB, Wells JA, Burnier JP, Ng PG. Probing steric and hydrophobic effects on enzyme-substrate interactions by protein engineering. Science (New York, N.Y.). 233: 659-63. PMID 17835820 DOI: 10.1126/Science.233.4764.659 |
0.332 |
|
| 2010 |
Wells JA, Wolan D, Zorn J, Datta D, Gray D, Sadowsky J. Abstract SY11-03: Turning enzymes on with small molecules Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Sy11-03 |
0.792 |
|
| 2009 |
Wolan DW, Zorn JA, Gray DC, Wells JA. Small-molecule activators of a proenzyme. Science (New York, N.Y.). 326: 853-8. PMID 19892984 DOI: 10.1126/Science.1177585 |
0.791 |
|
| 2009 |
Cha SW, Tadjuidje E, White J, Wells J, Mayhew C, Wylie C, Heasman J. Wnt11/5a complex formation caused by tyrosine sulfation increases canonical signaling activity. Current Biology : Cb. 19: 1573-80. PMID 19747829 DOI: 10.1016/J.Cub.2009.07.062 |
0.31 |
|
| 2009 |
Agard NJ, Wells JA. Methods for the proteomic identification of protease substrates. Current Opinion in Chemical Biology. 13: 503-9. PMID 19729334 DOI: 10.1016/J.Cbpa.2009.07.026 |
0.358 |
|
| 2009 |
Hardy JA, Wells JA. Dissecting an allosteric switch in caspase-7 using chemical and mutational probes. The Journal of Biological Chemistry. 284: 26063-9. PMID 19581639 DOI: 10.1074/Jbc.M109.001826 |
0.404 |
|
| 2009 |
Gao J, Sidhu SS, Wells JA. Two-state selection of conformation-specific antibodies. Proceedings of the National Academy of Sciences of the United States of America. 106: 3071-6. PMID 19208804 DOI: 10.1073/Pnas.0812952106 |
0.344 |
|
| 2008 |
Yoshihara HA, Mahrus S, Wells JA. Tags for labeling protein N-termini with subtiligase for proteomics. Bioorganic & Medicinal Chemistry Letters. 18: 6000-3. PMID 18762420 DOI: 10.1016/J.Bmcl.2008.08.044 |
0.708 |
|
| 2008 |
Mahrus S, Trinidad JC, Barkan DT, Sali A, Burlingame AL, Wells JA. Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini. Cell. 134: 866-76. PMID 18722006 DOI: 10.1016/J.Cell.2008.08.012 |
0.416 |
|
| 2008 |
Datta D, Scheer JM, Romanowski MJ, Wells JA. An allosteric circuit in caspase-1. Journal of Molecular Biology. 381: 1157-67. PMID 18590738 DOI: 10.1016/J.Jmb.2008.06.040 |
0.591 |
|
| 2007 |
Wells JA, McClendon CL. Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature. 450: 1001-9. PMID 18075579 DOI: 10.1038/Nature06526 |
0.746 |
|
| 2007 |
Tóth G, Mukhyala K, Wells JA. Computational approach to site-directed ligand discovery. Proteins. 68: 551-60. PMID 17444517 DOI: 10.1002/Prot.21402 |
0.358 |
|
| 2006 |
Scheer JM, Romanowski MJ, Wells JA. A common allosteric site and mechanism in caspases. Proceedings of the National Academy of Sciences of the United States of America. 103: 7595-600. PMID 16682620 DOI: 10.1073/Pnas.0602571103 |
0.404 |
|
| 2005 |
Scheer JM, Wells JA, Romanowski MJ. Malonate-assisted purification of human caspases. Protein Expression and Purification. 41: 148-53. PMID 15802232 DOI: 10.1016/J.Pep.2005.01.008 |
0.428 |
|
| 2005 |
Buck E, Wells JA. Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. Proceedings of the National Academy of Sciences of the United States of America. 102: 2719-24. PMID 15710877 DOI: 10.1073/Pnas.0500016102 |
0.317 |
|
| 2005 |
Buck E, Bourne H, Wells JA. Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor. The Journal of Biological Chemistry. 280: 4009-12. PMID 15550394 DOI: 10.1074/Jbc.C400500200 |
0.315 |
|
| 2004 |
Hardy JA, Wells JA. Searching for new allosteric sites in enzymes. Current Opinion in Structural Biology. 14: 706-15. PMID 15582395 DOI: 10.1016/J.Sbi.2004.10.009 |
0.357 |
|
| 2004 |
Hardy JA, Lam J, Nguyen JT, O'Brien T, Wells JA. Discovery of an allosteric site in the caspases. Proceedings of the National Academy of Sciences of the United States of America. 101: 12461-6. PMID 15314233 DOI: 10.1073/Pnas.0404781101 |
0.391 |
|
| 2004 |
Martin AG, Nguyen J, Wells JA, Fearnhead HO. Apo cytochrome c inhibits caspases by preventing apoptosome formation. Biochemical and Biophysical Research Communications. 319: 944-50. PMID 15184073 DOI: 10.1016/J.Bbrc.2004.05.084 |
0.357 |
|
| 2004 |
Erlanson DA, Wells JA, Braisted AC. Tethering: fragment-based drug discovery. Annual Review of Biophysics and Biomolecular Structure. 33: 199-223. PMID 15139811 DOI: 10.1146/Annurev.Biophys.33.110502.140409 |
0.354 |
|
| 2004 |
Arkin MR, Wells JA. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nature Reviews. Drug Discovery. 3: 301-17. PMID 15060526 DOI: 10.1038/Nrd1343 |
0.597 |
|
| 2003 |
Thanos CD, Randal M, Wells JA. Potent small-molecule binding to a dynamic hot spot on IL-2. Journal of the American Chemical Society. 125: 15280-1. PMID 14664558 DOI: 10.1021/Ja0382617 |
0.313 |
|
| 2003 |
Nguyen JT, Wells JA. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 7533-8. PMID 12808146 DOI: 10.1073/Pnas.1031631100 |
0.381 |
|
| 2003 |
Wells J, Arkin M, Braisted A, DeLano W, McDowell B, Oslob J, Raimundo B, Randal M. Drug discovery at signaling interfaces. Ernst Schering Research Foundation Workshop. 19-27. PMID 12664533 DOI: 10.1007/978-3-662-05314-0_3 |
0.476 |
|
| 2003 |
Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC. Binding of small molecules to an adaptive protein-protein interface. Proceedings of the National Academy of Sciences of the United States of America. 100: 1603-8. PMID 12582206 DOI: 10.1073/Pnas.252756299 |
0.616 |
|
| 2000 |
Sidhu SS, Lowman HB, Cunningham BC, Wells JA. Phage display for selection of novel binding peptides Methods in Enzymology. 328: 333-363. PMID 11075354 DOI: 10.1016/S0076-6879(00)28406-1 |
0.307 |
|
| 2000 |
Erlanson DA, Braisted AC, Raphael DR, Randal M, Stroud RM, Gordon EM, Wells JA. Site-directed ligand discovery. Proceedings of the National Academy of Sciences of the United States of America. 97: 9367-72. PMID 10944209 DOI: 10.1073/Pnas.97.17.9367 |
0.374 |
|
| 2000 |
Weiss GA, Wells JA, Sidhu SS. Mutational analysis of the major coat protein of M13 identifies residues that control protein display. Protein Science : a Publication of the Protein Society. 9: 647-54. PMID 10794407 DOI: 10.1110/Ps.9.4.647 |
0.588 |
|
| 2000 |
DeLano WL, Ultsch MH, De Vos AM, Wells JA. Convergent solutions to binding at a protein-protein interface Science. 287: 1279-1283. PMID 10678837 DOI: 10.1126/Science.287.5456.1279 |
0.377 |
|
| 2000 |
Sidhu SS, Weiss GA, Wells JA. High copy display of large proteins on phage for functional selections. Journal of Molecular Biology. 296: 487-95. PMID 10669603 DOI: 10.1006/Jmbi.1999.3465 |
0.599 |
|
| 1999 |
Atwell S, Wells JA. Selection for improved subtiligases by phage display Proceedings of the National Academy of Sciences of the United States of America. 96: 9497-9502. PMID 10449721 DOI: 10.1073/Pnas.96.17.9497 |
0.345 |
|
| 1999 |
Pearce KH, Cunningham BC, Fuh G, Teeri T, Wells JA. Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity Biochemistry. 38: 81-89. PMID 9890885 DOI: 10.1021/Bi9817008 |
0.345 |
|
| 1998 |
Fairbrother WJ, Christinger HW, Cochran AG, Fuh G, Keenan CJ, Quan C, Shriver SK, Tom JYK, Wells JA, Cunningham BC. Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site Biochemistry. 37: 17754-17764. PMID 9922141 DOI: 10.1021/Bi981931E |
0.304 |
|
| 1998 |
Arkin MR, Wells JA. Probing the importance of second sphere residues in an esterolytic antibody by phage display Journal of Molecular Biology. 284: 1083-1094. PMID 9837728 DOI: 10.1006/Jmbi.1998.2234 |
0.604 |
|
| 1998 |
Clackson T, Ultsch MH, Wells JA, De Vos AM. Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity Journal of Molecular Biology. 277: 1111-1128. PMID 9571026 DOI: 10.1006/Jmbi.1998.1669 |
0.33 |
|
| 1998 |
Ballinger MD, Jones JT, Lofgren JA, Fairbrother WJ, Akita RW, Sliwkowski MX, Wells JA. Selection of heregulin variants having higher affinity for the ErbB3 receptor by monovalent phage display Journal of Biological Chemistry. 273: 11675-11684. PMID 9565588 DOI: 10.1074/Jbc.273.19.11675 |
0.327 |
|
| 1998 |
Jones JT, Ballinger MD, Pisacane PI, Lofgren JA, Fitzpatrick VD, Fairbrother WJ, Wells JA, Sliwkowski MX. Binding interaction of the heregulinβ egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis Journal of Biological Chemistry. 273: 11667-11674. DOI: 10.1074/Jbc.273.19.11667 |
0.332 |
|
| 1997 |
Atwell S, Ultsch M, De Vos AM, Wells JA. Structural plasticity in a remodeled protein-protein interface Science. 278: 1125-1128. PMID 9353194 DOI: 10.1126/Science.278.5340.1125 |
0.328 |
|
| 1997 |
Scheidig AJ, Hynes TR, Pelletier LA, Wells JA, Kossiakoff AA. Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Science : a Publication of the Protein Society. 6: 1806-24. PMID 9300481 DOI: 10.1002/Pro.5560060902 |
0.352 |
|
| 1997 |
Starovasnik MA, Braisted AC, Wells JA. Structural mimicry of a native protein by a minimized binding domain Proceedings of the National Academy of Sciences of the United States of America. 94: 10080-10085. PMID 9294166 DOI: 10.1073/Pnas.94.19.10080 |
0.322 |
|
| 1997 |
Baca M, Scanlan TS, Stephenson RC, Wells JA. Phage display of a catalytic antibody to optimize affinity for transition-state analog binding. Proceedings of the National Academy of Sciences of the United States of America. 94: 10063-8. PMID 9294163 DOI: 10.1073/Pnas.94.19.10063 |
0.564 |
|
| 1997 |
Pearce KH, Potts BJ, Presta LG, Bald LN, Fendly BM, Wells JA. Mutational analysis of thrombopoietin for identification of receptor and neutralizing antibody sites Journal of Biological Chemistry. 272: 20595-20602. PMID 9252374 DOI: 10.1074/Jbc.272.33.20595 |
0.328 |
|
| 1997 |
Ellman J, Stoddard B, Wells J. Combinatorial thinking in chemistry and biology Proceedings of the National Academy of Sciences of the United States of America. 94: 2779-2782. PMID 9096292 DOI: 10.1073/Pnas.94.7.2779 |
0.303 |
|
| 1996 |
Ballinger MD, Tom J, Wells JA. Furilisin: A variant of subtilisin BPN' engineered for cleaving tribasic substrates Biochemistry. 35: 13579-13585. PMID 8885837 DOI: 10.1021/Bi961543H |
0.331 |
|
| 1996 |
Pearce KH, Ultsch MH, Kelley RF, de Vos AM, Wells JA. Structural and mutational analysis of affinity-inert contact residues at the growth hormone-receptor interface. Biochemistry. 35: 10300-7. PMID 8756685 DOI: 10.1021/Bi960513B |
0.307 |
|
| 1996 |
Braisted AC, Wells JA. Minimizing a binding domain from protein A Proceedings of the National Academy of Sciences of the United States of America. 93: 5688-5692. PMID 8650153 DOI: 10.1073/Pnas.93.12.5688 |
0.329 |
|
| 1996 |
Wells JA. Binding in the growth hormone receptor complex Proceedings of the National Academy of Sciences of the United States of America. 93: 1-6. PMID 8552582 DOI: 10.1073/Pnas.93.1.1 |
0.358 |
|
| 1996 |
Li B, Tom JY, Oare D, Yen R, Fairbrother WJ, Wells JA, Cunningham BC. Minimization of a polypeptide hormone. Science (New York, N.Y.). 270: 1657-60. PMID 7502074 DOI: 10.1126/Science.270.5242.1657 |
0.325 |
|
| 1995 |
Ballinger MD, Tom J, Wells JA. Designing subtilisin BPN' to cleave substrates containing dibasic residues Biochemistry. 34: 13312-13319. PMID 7577915 DOI: 10.1021/Bi00041A006 |
0.351 |
|
| 1995 |
Clackson T, Wells JA. A hot spot of binding energy in a hormone-receptor interface Science. 267: 383-386. PMID 7529940 DOI: 10.1126/Science.7529940 |
0.331 |
|
| 1995 |
Jackson DY, Burnier JP, Wells JA. Enzymatic cyclization of linear peptide esters using subtiligase Journal of the American Chemical Society. 117: 819-820. DOI: 10.1021/Ja00107A027 |
0.488 |
|
| 1994 |
Matthews DJ, Wells JA. Engineering an interfacial zinc site to increase hormone-receptor affinity Chemistry and Biology. 1: 25-30. PMID 9383367 DOI: 10.1016/1074-5521(94)90037-X |
0.31 |
|
| 1994 |
Wells JA, Fairbrother WJ, Otlewski J, Laskowski M, Burnier J. A reinvestigation of a synthetic peptide (TrPepz) designed to mimic trypsin Proceedings of the National Academy of Sciences of the United States of America. 91: 4110-4114. PMID 8183880 DOI: 10.1073/Pnas.91.10.4110 |
0.309 |
|
| 1994 |
Jamieson AC, Kim SH, Wells JA. In vitro selection of zinc fingers with altered DNA-binding specificity Biochemistry®. 33: 5689-5695. PMID 8180194 DOI: 10.1021/Bi00185A004 |
0.331 |
|
| 1994 |
Cunningham BC, Lowe DG, Li B, Bennett BD, Wells JA. Production of an atrial natriuretic peptide variant that is specific for type A receptor. The Embo Journal. 13: 2508-15. PMID 8013451 DOI: 10.1002/J.1460-2075.1994.Tb06540.X |
0.314 |
|
| 1994 |
Matthews DJ, Goodman LJ, Gorman CM, Wells JA. A survey of furin substrate specificity using substrate phage display Protein Science. 3: 1197-1205. PMID 7987214 DOI: 10.1002/Pro.5560030805 |
0.334 |
|
| 1994 |
Jackson DY, Burnier J, Quan C, Stanley M, Tom J, Wells JA. A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues. Science (New York, N.Y.). 266: 243-7. PMID 7939659 DOI: 10.1126/Science.7939659 |
0.538 |
|
| 1994 |
Chang TK, Jackson DY, Burnier JP, Wells JA. Subtiligase: a tool for semisynthesis of proteins. Proceedings of the National Academy of Sciences of the United States of America. 91: 12544-8. PMID 7809074 DOI: 10.1073/Pnas.91.26.12544 |
0.557 |
|
| 1994 |
Clackson T, Wells JA. In vitro selection from protein and peptide libraries Trends in Biotechnology. 12: 173-184. PMID 7764900 DOI: 10.1016/0167-7799(94)90079-5 |
0.359 |
|
| 1994 |
Jin L, Wells JA. Dissecting the energetics of an antibody-antigen interface by alanine shaving and molecular grafting Protein Science. 3: 2351-2357. PMID 7538848 DOI: 10.1002/Pro.5560031219 |
0.316 |
|
| 1994 |
Baumann G, Lowman HB, Mercado M, Wells JA. The stoichiometry of growth hormone-binding protein complexes in human plasma: comparison with cell surface receptors. The Journal of Clinical Endocrinology & Metabolism. 78: 1113-1118. DOI: 10.1210/Jcem.78.5.8175967 |
0.331 |
|
| 1993 |
Matthews DJ, Wells JA. Substrate phage: Selection of protease substrates by monovalent phage display Science. 260: 1113-1117. PMID 8493554 DOI: 10.1126/Science.8493554 |
0.347 |
|
| 1993 |
Lowman HB, Wells JA. Affinity maturation of human growth hormone by monovalent phage display Journal of Molecular Biology. 234: 564-478. PMID 8254660 DOI: 10.1006/Jmbi.1993.1612 |
0.339 |
|
| 1993 |
Cunningham BC, Wells JA. Comparison of a structural and a functional epitope Journal of Molecular Biology. 234: 554-563. PMID 7504735 DOI: 10.1006/Jmbi.1993.1611 |
0.305 |
|
| 1993 |
Wells JA, Cunningham BC, Fuh G, Lowman HB, Ultsch M, Devos AM, Bass SH, Mulkerrin MG. The Molecular Basis for Growth Hormone–Receptor Interactions Recent Progress in Hormone Research. 48: 253-275. DOI: 10.1016/B978-0-12-571148-7.50013-0 |
0.337 |
|
| 1992 |
Braxton S, Wells JA. Incorporation of a stabilizing Ca(2+)-binding loop into subtilisin BPN'. Biochemistry. 31: 7796-801. PMID 1510966 DOI: 10.1021/Bi00149A008 |
0.326 |
|
| 1992 |
Weber JR, Nelson C, Cunningham BC, Wells JA, Fong S. Immunodominant structures of human growth hormone identified by homolog-scanning mutagenesis. Molecular Immunology. 29: 1081-8. PMID 1495498 DOI: 10.1016/0161-5890(92)90040-5 |
0.311 |
|
| 1992 |
Jin L, Fendly BM, Wells JA. High resolution functional analysis of antibody-antigen interactions Journal of Molecular Biology. 226: 851-865. PMID 1380563 DOI: 10.1016/0022-2836(92)90636-X |
0.319 |
|
| 1992 |
Wells JA, Lowman HB. Rapid evolution of peptide and protein binding properties in vitro. Current Opinion in Biotechnology. 3: 355-62. PMID 1368436 DOI: 10.1016/0960-9822(92)90664-V |
0.348 |
|
| 1992 |
Fu YK, Arkins S, Fuh G, Cunningham BC, Wells JA, Fong S, Cronin MJ, Dantzer R, Kelley KW. Growth hormone augments superoxide anion secretion of human neutrophils by binding to the prolactin receptor. The Journal of Clinical Investigation. 89: 451-7. PMID 1310696 DOI: 10.1172/Jci115605 |
0.304 |
|
| 1991 |
Carter P, Abrahmsén L, Wells JA. Probing the mechanism and improving the rate of substrate-assisted catalysis in subtilisin BPN′ Biochemistry. 30: 6142-6148. PMID 2059622 DOI: 10.1021/Bi00239A009 |
0.313 |
|
| 1991 |
Bass SH, Mulkerrin MG, Wells JA. A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor Proceedings of the National Academy of Sciences of the United States of America. 88: 4498-4502. PMID 2034689 DOI: 10.1073/Pnas.88.10.4498 |
0.308 |
|
| 1991 |
Wells JA. Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution Biochemistry. 30: 4151-4159. PMID 2021606 DOI: 10.1021/Bi00231A007 |
0.332 |
|
| 1991 |
Cunningham BC, Ultsch M, De Vos AM, Mulkerrin MG, Clauser KR, Wells JA. Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science (New York, N.Y.). 254: 821-5. PMID 1948064 DOI: 10.1126/Science.1948064 |
0.346 |
|
| 1991 |
Lowman HB, Bass SH, Simpson N, Wells JA. Selecting high-affinity binding proteins by monovalent phage display. Biochemistry. 30: 10832-8. PMID 1932005 DOI: 10.1021/Bi00109A004 |
0.312 |
|
| 1991 |
Wells JA. Systematic mutational analyses of protein-protein interfaces Methods in Enzymology. 202: 390-411. PMID 1723781 DOI: 10.1016/0076-6879(91)02020-A |
0.333 |
|
| 1991 |
Lowman HB, Wells JA. Monovalent phage display: A method for selecting variant proteins from random libraries Methods. 3: 205-216. DOI: 10.1016/S1046-2023(05)80173-2 |
0.338 |
|
| 1990 |
Cunningham BC, Henner DJ, Wells JA. Engineering human prolactin to bind to the human growth hormone receptor Science. 247: 1461-1465. PMID 2321008 DOI: 10.1126/Science.2321008 |
0.33 |
|
| 1990 |
Cunningham BC, Bass S, Fuh G, Wells JA. Zinc mediation of the binding of human growth hormone to the human prolactin receptor Science. 250: 1709-1712. PMID 2270485 DOI: 10.1126/Science.2270485 |
0.306 |
|
| 1990 |
Carter P, Wells JA. Functional interaction among catalytic residues in subtilisin BPN' Proteins: Structure, Function and Genetics. 7: 335-342. PMID 2199971 DOI: 10.1002/Prot.340070405 |
0.34 |
|
| 1990 |
Ellerby LM, Escobar WA, Fink AL, Mitchinson C, Wells JA. The role of lysine-234 in beta-lactamase catalysis probed by site-directed mutagenesis. Biochemistry. 29: 5797-806. PMID 1974463 DOI: 10.1021/Bi00476A022 |
0.304 |
|
| 1990 |
Bass S, Greene R, Wells JA. Hormone phage: An enrichment method for variant proteins with altered binding properties Proteins: Structure, Function and Genetics. 8: 309-314. PMID 1708882 DOI: 10.1002/Prot.340080405 |
0.338 |
|
| 1989 |
Carter P, Nilsson B, Burnier JP, Burdick D, Wells JA. Engineering subtilisin BPN' for site-specific proteolysis Proteins: Structure, Function and Genetics. 6: 240-248. PMID 2516317 DOI: 10.1002/Prot.340060306 |
0.402 |
|
| 1989 |
Cunningham BC, Wells JA. High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis Science. 244: 1081-1085. PMID 2471267 DOI: 10.1126/Science.2471267 |
0.308 |
|
| 1989 |
Cunningham BC, Jhurani P, Ng P, Wells JA. Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis Science. 243: 1330-1336. PMID 2466339 DOI: 10.1126/Science.2466339 |
0.309 |
|
| 1988 |
Carter P, Wells JA. Dissecting the catalytic triad of a serine protease Nature. 332: 564-568. PMID 3282170 DOI: 10.1038/332564A0 |
0.333 |
|
| 1987 |
Wells JA, Powers DB, Bott RR, Graycar TP, Estell DA. Designing substrate specificity by protein engineering of electrostatic interactions. Proceedings of the National Academy of Sciences of the United States of America. 84: 1219-23. PMID 3547407 DOI: 10.1073/Pnas.84.5.1219 |
0.322 |
|
| 1987 |
Carter P, Wells JA. Engineering enzyme specificity by 'substrate-assisted catalysis' Science. 237: 394-399. PMID 3299704 DOI: 10.1126/Science.3299704 |
0.323 |
|
| 1987 |
Wells JA, Cunningham BC, Graycar TP, Estell DA. Recruitment of substrate-specificity properties from one enzyme into a related one by protein engineering Proceedings of the National Academy of Sciences of the United States of America. 84: 5167-5171. PMID 3299378 DOI: 10.1073/Pnas.84.15.5167 |
0.323 |
|
| 1985 |
Nakamaye KL, Wells JA, Bridenbaugh RL, Okamoto Y, Yount RG. 2-[(4-Azido-2-nitrophenyl)amino]ethyl triphosphate, a novel chromophoric and photoaffinity analogue of ATP. Synthesis, characterization, and interaction with myosin subfragment 1. Biochemistry. 24: 5226-35. PMID 4074691 DOI: 10.1021/Bi00340A041 |
0.654 |
|
| 1985 |
Wells JA, Vasser M, Powers DB. Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites Gene. 34: 315-323. PMID 3891521 DOI: 10.1016/0378-1119(85)90140-4 |
0.304 |
|
| 1984 |
Wells JA, Swyryd EA, Stark GR. An improved method for purifying 2',5'-oligoadenylate synthetases. The Journal of Biological Chemistry. 259: 1363-70. PMID 6693390 |
0.455 |
|
| 1984 |
Perkins WJ, Wells JA, Yount RG. Characterization of the properties of ethenoadenosine nucleotides bound or trapped at the active site of myosin subfragment 1. Biochemistry. 23: 3994-4002. PMID 6237680 DOI: 10.1021/Bi00312A029 |
0.636 |
|
| 1983 |
Dalbey RE, Wells JA, Yount RG. Trapping of transition metal-nucleotide complexes in myosin subfragment 1 by cross-linking thiols; divalent transition metal probes of the active site. Biochemistry. 22: 490-6. PMID 6824640 DOI: 10.1021/Bi00271A036 |
0.721 |
|
| 1983 |
Wells JA, Ferrari E, Henner DJ, Estell DA, Chen EY. Cloning, sequencing, and secretion of bacillus amyloliquefaciens subtillisin in Bacillus subtilis Nucleic Acids Research. 11: 7911-7925. DOI: 10.1093/Nar/11.22.7911 |
0.307 |
|
| 1982 |
Wells JA, Yount RG. Chemical modification of myosin by active-site trapping of metal-nucleotides with thiol crosslinking reagents. Methods in Enzymology. 85: 93-116. PMID 7121292 DOI: 10.1016/0076-6879(82)85013-1 |
0.652 |
|
| 1980 |
Wells JA, Knoeber C, Sheldon MC, Werber MM, Yount RG. Cross-linking of myosin subfragment 1. Nucleotide-enhanced modification by a variety of bifunctional reagents. The Journal of Biological Chemistry. 255: 11135-40. PMID 7440533 |
0.566 |
|
| 1980 |
Wells JA, Werber MM, Yount RG. Mechanism of inactivation of myosin subfragment 1 by Co(III)phenATP. A reinvestigation. The Journal of Biological Chemistry. 255: 7552-5. PMID 6447149 |
0.557 |
|
| 1980 |
Wells JA, Yount RG. Reaction of 5,5'-dithiobis(2-nitrobenzoic acid) with myosin subfragment one: evidence for formation of a single protein disulfide with trapping of metal nucleotide at the active site. Biochemistry. 19: 1711-7. PMID 6445748 DOI: 10.1021/Bi00549A030 |
0.639 |
|
| 1980 |
Wells JA, Sheldon M, Yount RG. Magnesium nucleotide is stoichiometrically trapped at the active site of myosin and its active proteolytic fragments by thiol cross-linking reagents. The Journal of Biological Chemistry. 255: 1598-602. PMID 6444414 |
0.619 |
|
| 1979 |
Wells JA, Werber MM, Yount RG. Inactivation of myosin subfragment one by cobalt(II)/cobalt(III) phenanthroline complexes. 2. Cobalt chelation of two critical SH groups. Biochemistry. 18: 4800-5. PMID 159719 DOI: 10.1021/Bi00589A006 |
0.586 |
|
| 1979 |
Wells JA, Yount RG. Active site trapping of nucleotides by crosslinking two sulfhydryls in myosin subfragment 1. Proceedings of the National Academy of Sciences of the United States of America. 76: 4966-70. PMID 159451 DOI: 10.1073/Pnas.76.10.4966 |
0.643 |
|
| 1979 |
Wells JA, Werber MM, Legg JI, Yount RG. Inactivation of myosin subfragment one by cobalt(II)/cobalt(III) phenanthroline complexes. I. Incorporation of Co(III) by in situ oxidation of Co(II). Biochemistry. 18: 4793-9. PMID 41570 |
0.539 |
|
| Show low-probability matches. |
