| Year |
Citation |
Score |
| 2024 |
Kwon JJ, Dilly J, Liu S, Kim E, Bian Y, Dharmaiah S, Tran TH, Kapner KS, Ly SH, Yang X, Rabara D, Waybright TJ, Giacomelli AO, Hong AL, Misek S, ... ... Aguirre AJ, et al. Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity. Biorxiv : the Preprint Server For Biology. PMID 39484452 DOI: 10.1101/2024.10.22.618529 |
0.679 |
|
| 2024 |
Singh H, Xiu J, Kapner KS, Yuan C, Narayan RR, Oberley M, Farrell A, Surana R, Huffman BM, Perez K, Cleary JM, Jordan AC, Dias Costa A, Williams HL, Raghavan S, ... ... Aguirre AJ, et al. Clinical and genomic features of classical and basal transcriptional subtypes in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 39283131 DOI: 10.1158/1078-0432.CCR-24-1164 |
0.309 |
|
| 2024 |
Aguirre AJ, Stanger BZ, Maitra A. Hope on the Horizon: A Revolution in KRAS Inhibition Is Creating a New Treatment Paradigm for Patients with Pancreatic Cancer. Cancer Research. 84: 2950-2953. PMID 39279379 DOI: 10.1158/0008-5472.CAN-24-1926 |
0.34 |
|
| 2024 |
Holderfield M, Lee BJ, Jiang J, Tomlinson A, Seamon KJ, Mira A, Patrucco E, Goodhart G, Dilly J, Gindin Y, Dinglasan N, Wang Y, Lai LP, Cai S, Jiang L, ... ... Aguirre AJ, et al. Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature. PMID 38589574 DOI: 10.1038/s41586-024-07205-6 |
0.311 |
|
| 2024 |
Tong X, Patel AS, Kim E, Li H, Chen Y, Li S, Liu S, Dilly J, Kapner KS, Zhang N, Xue Y, Hover L, Mukhopadhyay S, Sherman F, Myndzar K, ... ... Aguirre AJ, et al. Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer. Cancer Cell. PMID 38402609 DOI: 10.1016/j.ccell.2024.01.012 |
0.351 |
|
| 2024 |
Singh H, Sahgal P, Kapner K, Corsello SM, Gupta H, Gujrathi R, Li YY, Cherniack AD, El Alam R, Kerfoot J, Andrews E, Lee A, Nambiar C, Hannigan AM, Remland J, ... ... Aguirre AJ, et al. RAS/RAF co-mutation and ERBB2 copy number modulates HER2 heterogeneity and responsiveness to HER2-directed therapy in colorectal cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 38345769 DOI: 10.1158/1078-0432.CCR-23-2581 |
0.322 |
|
| 2023 |
Schaefer A, Hodge RG, Zhang H, Hobbs GA, Dilly J, Huynh MV, Goodwin CM, Zhang F, Diehl JN, Pierobon M, Baldelli E, Javaid S, Guthrie K, Rashid NU, Petricoin EF, ... ... Aguirre AJ, et al. RHOA drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling. Science Signaling. 16: eadg5289. PMID 38113333 DOI: 10.1126/scisignal.adg5289 |
0.491 |
|
| 2023 |
Singh H, Keller RB, Kapner KS, Dilly J, Raghavan S, Yuan C, Cohen EF, Tolstorukov M, Andrews E, Brais LK, da Silva A, Perez K, Rubinson DA, Surana R, Giannakis M, ... ... Aguirre AJ, et al. Oncogenic drivers and therapeutic vulnerabilities in KRAS wild-type pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 37463056 DOI: 10.1158/1078-0432.CCR-22-3930 |
0.306 |
|
| 2023 |
Qiang L, Hoffman MT, Ali LR, Castillo JI, Kageler L, Temesgen A, Lenehan P, Wang SJ, Bello E, Cardot-Ruffino V, Uribe GA, Yang A, Dougan M, Aguirre AJ, Raghavan S, et al. TGFβ blockade in pancreatic cancer enhances sensitivity to combination chemotherapy. Gastroenterology. PMID 37263309 DOI: 10.1053/j.gastro.2023.05.038 |
0.31 |
|
| 2023 |
de Matos Simoes R, Shirasaki R, Downey-Kopyscinski SL, Matthews GM, Barwick BG, Gupta VA, Dupéré-Richer D, Yamano S, Hu Y, Sheffer M, Dhimolea E, Dashevsky O, Gandolfi S, Ishiguro K, Meyers RM, ... ... Aguirre AJ, et al. Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias. Nature Cancer. 4: 754-773. PMID 37237081 DOI: 10.1038/s43018-023-00550-x |
0.478 |
|
| 2023 |
Koide E, Mohardt ML, Doctor ZM, Yang A, Hao M, Donovan KA, Kuismi CC, Nelson AJ, Abell K, Aguiar M, Che J, Stokes MP, Zhang T, Aguirre AJ, Fischer ES, et al. Development and characterization of selective FAK inhibitors and PROTACs with in vivo activity. Chembiochem : a European Journal of Chemical Biology. e202300141. PMID 37088717 DOI: 10.1002/cbic.202300141 |
0.318 |
|
| 2023 |
Perurena N, Lock R, Davis RA, Raghavan S, Pilla NF, Ng R, Loi P, Guild CJ, Miller AL, Sicinska E, Cleary JM, Rubinson DA, Wolpin BM, Gray NS, Santagata S, ... ... Aguirre AJ, et al. USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities. Cell Reports. Medicine. 101007. PMID 37030295 DOI: 10.1016/j.xcrm.2023.101007 |
0.494 |
|
| 2022 |
Williams HL, Dias Costa A, Zhang J, Raghavan S, Winter PS, Kapner KS, Ginebaugh SP, Väyrynen SA, Väyrynen JP, Yuan C, Navia AW, Wang J, Yang A, Bosse TL, Kalekar RL, ... ... Aguirre AJ, et al. Spatially-resolved single-cell assessment of pancreatic cancer expression subtypes reveals co-expressor phenotypes and extensive intra-tumoral heterogeneity. Cancer Research. PMID 36459568 DOI: 10.1158/0008-5472.CAN-22-3050 |
0.433 |
|
| 2022 |
Ursu O, Neal JT, Shea E, Thakore PI, Jerby-Arnon L, Nguyen L, Dionne D, Diaz C, Bauman J, Mosaad MM, Fagre C, Lo A, McSharry M, Giacomelli AO, Ly SH, ... ... Aguirre AJ, et al. Author Correction: Massively parallel phenotyping of coding variants in cancer with Perturb-seq. Nature Biotechnology. 40: 1691. PMID 36258042 DOI: 10.1038/s41587-022-01495-9 |
0.474 |
|
| 2022 |
Kwon JJ, Hajian B, Bian Y, Young LC, Amor AJ, Fuller JR, Fraley CV, Sykes AM, So J, Pan J, Baker L, Lee SJ, Wheeler DB, Mayhew DL, Persky NS, ... ... Aguirre AJ, et al. Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature. PMID 35831509 DOI: 10.1038/s41586-022-04928-2 |
0.427 |
|
| 2022 |
Rubinson D, Wolpin BM, Warsofsky IS, Ryan DP, Perez K, Rahma O, Singh H, Yurgelun MB, Shapiro GI, Aguirre AJ, D'Andrea AD, Cleary JM. Durable clinical benefit from PARP inhibition in a platinum-sensitive, BRCA2-mutated pancreatic cancer patient after earlier progression on placebo treatment on the POLO trial: a case report. Journal of Gastrointestinal Oncology. 12: 3133-3140. PMID 35070436 DOI: 10.21037/jgo-21-197 |
0.333 |
|
| 2022 |
Ursu O, Neal JT, Shea E, Thakore PI, Jerby-Arnon L, Nguyen L, Dionne D, Diaz C, Bauman J, Mosaad MM, Fagre C, Lo A, McSharry M, Giacomelli AO, Ly SH, ... ... Aguirre AJ, et al. Massively parallel phenotyping of coding variants in cancer with Perturb-seq. Nature Biotechnology. PMID 35058622 DOI: 10.1038/s41587-021-01160-7 |
0.52 |
|
| 2021 |
Raghavan S, Winter PS, Navia AW, Williams HL, DenAdel A, Lowder KE, Galvez-Reyes J, Kalekar RL, Mulugeta N, Kapner KS, Raghavan MS, Borah AA, Liu N, Väyrynen SA, Costa AD, ... ... Aguirre AJ, et al. Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer. Cell. 184: 6119-6137.e26. PMID 34890551 DOI: 10.1016/j.cell.2021.11.017 |
0.444 |
|
| 2021 |
Dai C, Rennhack JP, Arnoff TE, Thaker M, Younger ST, Doench JG, Huang AY, Yang A, Aguirre AJ, Wang B, Mun E, O'Connell JT, Huang Y, Labella K, Talamas JA, et al. SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization. Cell Reports. 36: 109443. PMID 34320363 DOI: 10.1016/j.celrep.2021.109443 |
0.719 |
|
| 2021 |
Neggers JE, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Yang A, Kalekar RL, Krill-Burger JM, Dharia NV, Kugener G, Kalfon J, Yuan C, Dumont N, Gonzalez A, Abdusamad M, ... ... Aguirre AJ, et al. Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Reports. 36: 109367. PMID 34260938 DOI: 10.1016/j.celrep.2021.109367 |
0.67 |
|
| 2021 |
Neggers JE, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Yang A, Kalekar RL, Krill-Burger JM, Dharia NV, Kugener G, Kalfon J, Yuan C, Dumont N, Gonzalez A, Abdusamad M, ... ... Aguirre AJ, et al. Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Reports. 36: 109367. PMID 34260938 DOI: 10.1016/j.celrep.2021.109367 |
0.67 |
|
| 2021 |
Waters AM, Khatib TO, Papke B, Goodwin CM, Hobbs GA, Diehl JN, Yang R, Edwards AC, Walsh KH, Sulahian R, McFarland JM, Kapner KS, Gilbert TSK, Stalnecker CA, Javaid S, ... ... Aguirre AJ, et al. Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition. Cell Reports. 35: 109291. PMID 34192548 DOI: 10.1016/j.celrep.2021.109291 |
0.584 |
|
| 2021 |
Waters AM, Khatib TO, Papke B, Goodwin CM, Hobbs GA, Diehl JN, Yang R, Edwards AC, Walsh KH, Sulahian R, McFarland JM, Kapner KS, Gilbert TSK, Stalnecker CA, Javaid S, ... ... Aguirre AJ, et al. Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition. Cell Reports. 35: 109291. PMID 34192548 DOI: 10.1016/j.celrep.2021.109291 |
0.584 |
|
| 2020 |
Neggers JE, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Yang A, Kalekar RL, Krill-Burger JM, Dharia NV, Kugener G, Kalfon J, Yuan C, Dumont N, Gonzalez A, Abdusamad M, ... ... Aguirre AJ, et al. Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Reports. 33: 108493. PMID 33326793 DOI: 10.1016/j.celrep.2020.108493 |
0.727 |
|
| 2020 |
Ferguson FM, Nabet B, Raghavan S, Liu Y, Leggett AL, Kuljanin M, Kalekar RL, Yang A, He S, Wang J, Ng RWS, Sulahian R, Li L, Poulin EJ, Huang L, ... ... Aguirre AJ, et al. Discovery of a selective inhibitor of doublecortin like kinase 1. Nature Chemical Biology. PMID 32251410 DOI: 10.1038/S41589-020-0506-0 |
0.508 |
|
| 2020 |
Perez K, Cleary JM, Karasic TB, Raghavan S, Rahma OE, Nowak J, Borazanci EH, Downes M, Drebin JA, Tuveson DA, Ting DT, Moffitt R, Yeh JJ, Aguirre A, Evans R, et al. Vitamin D receptor agonist paricalcitol plus gemcitabine and nab-paclitaxel in patients with metastatic pancreatic cancer. Journal of Clinical Oncology. 38: TPS784-TPS784. DOI: 10.1200/Jco.2020.38.4_Suppl.Tps784 |
0.327 |
|
| 2020 |
Yurgelun MB, Chittenden AB, Ukaegbu CI, Perez K, Madigan AP, Gaonkar S, Cleary JM, Aguirre A, Wolpin BM, Syngal S. Implementation of systematic genetic counseling (GC) and multigene germline testing (MGT) for pancreatic cancer (PC) patients (pts). Journal of Clinical Oncology. 38: 678-678. DOI: 10.1200/Jco.2020.38.4_Suppl.678 |
0.369 |
|
| 2020 |
Hwang WL, Jagadeesh K, Guo J, Hoffman HI, Ashenberg O, Drokhlyansky E, Van Wittenberghe N, Farhi S, Schapiro D, Rodrigues C, Ciprani D, Zollinger D, Hong TS, Aguirre A, Mino-Kenudson M, et al. Single-nucleus RNA-seq of frozen archival primary pancreatic ductal adenocarcinoma uncovers multi-compartment intratumoral heterogeneity associated with neoadjuvant treatment. Journal of Clinical Oncology. 38: 4633-4633. DOI: 10.1200/Jco.2020.38.15_Suppl.4633 |
0.325 |
|
| 2020 |
Winter PS, Raghavan S, Navia AW, Williams H, Galvez-Reyes J, Kalekar R, Borah A, DenAdel A, Raghavan M, Lowder K, Mulugeta N, Wang J, Reilly E, Brais L, Crawford L, ... ... Aguirre AJ, et al. Abstract PR02: Matched metastatic pancreatic ductal adenocarcinoma biopsies and organoid models reveal tumor cell transcriptional plasticity and subtype-specific microenvironmental crosstalk Cancer Research. 80. DOI: 10.1158/1538-7445.Camodels2020-Pr02 |
0.46 |
|
| 2020 |
Neggers JE, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Kalekar RL, Krill-Burger JM, Hong AL, Kugener G, Kalfon J, Yang A, Yuan C, Dumont N, Gonzalez A, Abdusamad M, ... ... Aguirre AJ, et al. Abstract LB-053: VPS4A is a synthetic lethal target in VPS4B-deficient cancers due to co-deletion with SMAD4 Cancer Research. 80. DOI: 10.1158/1538-7445.Am2020-Lb-053 |
0.714 |
|
| 2020 |
Neggers J, Paolella B, Asfaw A, Rothberg M, Skipper T, Kalekar R, Burger M, Kugener G, Jérémie K, Yang A, Nancy D, Abdusamad M, Cherniack A, Tscherniak A, Hong A, ... ... Aguirre A, et al. Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers with chromosome 18q or 16q deletion European Journal of Cancer. 138: S8. DOI: 10.1016/s0959-8049(20)31088-1 |
0.614 |
|
| 2019 |
Zhang H, Christensen CL, Dries R, Oser MG, Deng J, Diskin B, Li F, Pan Y, Zhang X, Yin Y, Papadopoulos E, Pyon V, Thakurdin C, Kwiatkowski N, Jani K, ... ... Aguirre AJ, et al. CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Cancer Cell. PMID 31883968 DOI: 10.1016/J.Ccell.2019.11.003 |
0.32 |
|
| 2019 |
Hobbs GA, Baker NM, Miermont AM, Thurman RD, Pierobon M, Tran TH, Anderson AO, Waters AM, Diehl JN, Papke B, Hodge RG, Klomp JE, Goodwin CM, DeLiberty JM, Wang J, ... ... Aguirre AJ, et al. Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer. Cancer Discovery. PMID 31649109 DOI: 10.1158/2159-8290.Cd-19-1006 |
0.337 |
|
| 2019 |
Sulahian R, Kwon JJ, Walsh KH, Pailler E, Bosse TL, Thaker M, Almanza D, Dempster JM, Pan J, Piccioni F, Dumont N, Gonzalez A, Rennhack J, Nabet B, Bachman JA, ... ... Aguirre AJ, et al. Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers. Cell Reports. 29: 118-134.e8. PMID 31577942 DOI: 10.1016/J.Celrep.2019.08.090 |
0.546 |
|
| 2019 |
Aguirre AJ. Oncogenic NRG1 fusions: A new hope for targeted therapy in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31164372 DOI: 10.1158/1078-0432.CCR-19-1280 |
0.355 |
|
| 2019 |
Bhola PD, Ahmed E, Guerriero J, Sicinska E, Su E, Ni J, Lavrova E, Chipashvili O, Hagan T, Ng K, Aguirre A, Lorch J, George S, Demetri G, Zhao J, et al. Abstract 4478: High-throughput dynamic BH3 profiling identifies active cancer therapies in solid tumors Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-4478 |
0.394 |
|
| 2019 |
Raghavan S, Winter PS, Navia A, Kalekar R, Galvez-Reyes J, Prakadan S, Wang J, Reilly E, Brais L, Cleary JM, Nowak J, Wolpin BM, Shalek AK, Aguirre AJ, Hahn WC. Abstract PR15: Assessment of tumor heterogeneity, clonal evolution, and the stromal microenvironment in metastatic pancreatic ductal adenocarcinoma and matched patient-derived organoids Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-Pr15 |
0.455 |
|
| 2019 |
Keller RB, Mazor T, Giannakis M, Nowak J, Sholl L, Aguirre A, Bass A, Sethi N, Nagaraja A, Brais L, Reilly E, Cerami E, Wolpin B. Abstract C130: Precision oncology decision support within the Gastrointestinal Cancer Center at Dana-Farber Cancer Institute (GI TARGET) Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-C130 |
0.433 |
|
| 2019 |
Shirasaki R, de Matos Simoes R, Downey-Kopyscinski S, Matthews G, Hu Y, Sheffer M, Dhimolea E, Dashevsky O, Gandolfi S, Hengeveld P, Dempster J, Meyers R, Bryan J, Dharia N, McFarland J, ... ... Aguirre A, et al. CRISPR studies identify genes preferentially essential for myeloma cells vs. other neoplasias: implications for future therapies selective against MM Clinical Lymphoma Myeloma and Leukemia. 19: e48-e49. DOI: 10.1016/J.Clml.2019.09.073 |
0.42 |
|
| 2018 |
Aguirre AJ. Pancreatic Cancer Subtypes: Beyond Lumping and Splitting. Gastroenterology. PMID 30419209 DOI: 10.1053/j.gastro.2018.11.004 |
0.316 |
|
| 2018 |
Giacomelli AO, Yang X, Lintner RE, McFarland JM, Duby M, Kim J, Howard TP, Takeda DY, Ly SH, Kim E, Gannon HS, Hurhula B, Sharpe T, Goodale A, Fritchman B, ... ... Aguirre AJ, et al. Mutational processes shape the landscape of TP53 mutations in human cancer. Nature Genetics. PMID 30224644 DOI: 10.1038/S41588-018-0204-Y |
0.497 |
|
| 2018 |
Lo JH, Hao L, Muzumdar MD, Raghavan S, Kwon EJ, Pulver EM, Hsu F, Aguirre AJ, Wolpin BM, Fuchs CS, Hahn WC, Jacks T, Bhatia SN. iRGD-guided tumor-penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer. Molecular Cancer Therapeutics. PMID 30097486 DOI: 10.1158/1535-7163.Mct-17-1090 |
0.487 |
|
| 2018 |
Yurgelun MB, Chittenden AB, Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Qian ZR, Welch MW, Brais LK, Da Silva A, Bui JL, Yuan C, Li T, Li W, Masuda A, ... ... Aguirre AJ, et al. Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 29961768 DOI: 10.1038/S41436-018-0009-5 |
0.513 |
|
| 2018 |
Li S, Liu S, Deng J, Akbay EA, Hai J, Ambrogio C, Zhang L, Zhou F, Jenkins RW, Adeegbe DO, Gao P, Wang X, Paweletz CP, Herter-Sprie GS, Chen T, ... ... Aguirre AJ, et al. Assessing Therapeutic Efficacy of MEK Inhibition in a KRAS G12C-Driven Mouse Model of Lung Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29945997 DOI: 10.1158/1078-0432.Ccr-17-3438 |
0.358 |
|
| 2018 |
Aguirre AJ, Nowak JA, Camarda ND, Moffitt RA, Ghazani AA, Hazar-Rethinam M, Raghavan S, Kim J, Brais LK, Ragon D, Welch MW, Reilly E, McCabe D, Marini L, Anderka K, et al. Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine. Cancer Discovery. PMID 29903880 DOI: 10.1158/2159-8290.Cd-18-0275 |
0.475 |
|
| 2018 |
Tiriac H, Belleau P, Engle DD, Plenker D, Deschênes A, Somerville T, Froeling FEM, Burkhart RA, Denroche RE, Jang GH, Miyabayashi K, Young CM, Patel H, Ma M, LaComb JF, ... ... Aguirre AJ, et al. Organoid profiling identifies common responders to chemotherapy in pancreatic cancer. Cancer Discovery. PMID 29853643 DOI: 10.1158/2159-8290.Cd-18-0349 |
0.33 |
|
| 2018 |
Perez K, Weekes CD, Cleary JM, Abrams TA, Blaszkowsky LS, Enzinger PC, Giannakis M, Goyal L, Meyerhardt JA, Rubinson DA, Yurgelun MB, Stonely D, Raghavan S, Bakir B, Das K, ... ... Aguirre A, et al. Phase Ib study of gemcitabine, nab-paclitaxel, and ficlatuzumab in patients with advanced pancreatic cancer. Journal of Clinical Oncology. 36: 693-693. DOI: 10.1200/Jco.2020.38.4_Suppl.693 |
0.347 |
|
| 2017 |
Bullman S, Pedamallu CS, Sicinska E, Clancy TE, Zhang X, Cai D, Neuberg D, Huang K, Guevara F, Nelson T, Chipashvili O, Hagan T, Walker M, Ramachandran A, Diosdado B, ... ... Aguirre AJ, et al. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science (New York, N.Y.). PMID 29170280 DOI: 10.1126/Science.Aal5240 |
0.539 |
|
| 2017 |
Gu M, Nishihara R, Chen Y, Li W, Shi Y, Masugi Y, Hamada T, Kosumi K, Liu L, da Silva A, Nowak JA, Twombly T, Du C, Koh H, Li W, ... ... Aguirre AJ, et al. Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells. Oncotarget. 8: 87379-87389. PMID 29152088 DOI: 10.18632/Oncotarget.20972 |
0.302 |
|
| 2017 |
Aguirre AJ, Hahn WC. Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers. Cold Spring Harbor Perspectives in Medicine. PMID 29101114 DOI: 10.1101/Cshperspect.A031518 |
0.579 |
|
| 2017 |
Qian ZR, Rubinson DA, Nowak JA, Morales-Oyarvide V, Dunne RF, Kozak MM, Welch MW, Brais LK, Da Silva A, Li T, Li W, Masuda A, Yang J, Shi Y, Gu M, ... ... Aguirre A, et al. Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma. Jama Oncology. PMID 29098284 DOI: 10.1001/Jamaoncol.2017.3420 |
0.446 |
|
| 2017 |
Krall EB, Wang B, Munoz DM, Ilic N, Raghavan S, Niederst MJ, Yu K, Ruddy DA, Aguirre AJ, Kim JW, Redig AJ, Gainor JF, Williams JA, Asara JM, Doench JG, et al. Correction: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. Elife. 6. PMID 29087937 DOI: 10.7554/Elife.33173 |
0.719 |
|
| 2017 |
Kim JW, Abudayyeh OO, Yeerna H, Yeang CH, Stewart M, Jenkins RW, Kitajima S, Konieczkowski DJ, Medetgul-Ernar K, Cavazos T, Mah C, Ting S, Van Allen EM, Cohen O, Mcdermott J, ... ... Aguirre AJ, et al. Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States. Cell Systems. 5: 105-118.e9. PMID 28837809 DOI: 10.1016/J.Cels.2017.08.002 |
0.502 |
|
| 2017 |
Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. PMID 28678785 DOI: 10.1038/Nature23007 |
0.482 |
|
| 2017 |
Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, et al. PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396387 DOI: 10.1073/Pnas.1617922114 |
0.517 |
|
| 2017 |
Wang B, Krall EB, Aguirre AJ, Kim M, Widlund HR, Doshi MB, Sicinska E, Sulahian R, Goodale A, Cowley GS, Piccioni F, Doench JG, Root DE, Hahn WC. ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition. Cell Reports. 18: 1543-1557. PMID 28178529 DOI: 10.1016/J.Celrep.2017.01.031 |
0.738 |
|
| 2017 |
Krall EB, Wang B, Munoz DM, Ilic N, Raghavan S, Niederst MJ, Yu K, Ruddy DA, Aguirre AJ, Kim JW, Redig AJ, Gainor JF, Williams JA, Asara JM, Doench JG, et al. KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. Elife. 6. PMID 28145866 DOI: 10.7554/Elife.18970 |
0.55 |
|
| 2017 |
Krall EB, Wang B, Munoz DM, Ilic N, Raghavan S, Niederst MJ, Yu K, Ruddy DA, Aguirre AJ, Kim JW, Redig AJ, Gainor JF, Williams JA, Asara JM, Doench JG, et al. Author response: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer Elife. DOI: 10.7554/Elife.18970.029 |
0.522 |
|
| 2017 |
Meyers RM, Aguirre AJ, Weir BA, Vazquez F, Zhang C, Ben-David U, Cook A, Ha G, Harrington WF, Doshi M, Gill S, Xu H, Ali LD, Jiang G, Pantel S, et al. Abstract B39: Genomic copy number alterations introduce a gene-independent viability bias in CRISPR-Cas9 knock-out screens of cancer cell lines Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Pmccavuln16-B39 |
0.549 |
|
| 2017 |
Kim E, Ly SH, Persky NS, Wang B, Yang X, Piccioni F, Labella K, Doshi M, Lintner RE, Zhu C, Steelman S, Root DE, Johannessen CM, Burgin AB, MacConaill LE, ... ... Aguirre AJ, et al. Abstract 394: Saturation mutagenesis of KRAS reveals the functional landscape of missense variants Cancer Research. 77: 394-394. DOI: 10.1158/1538-7445.Am2017-394 |
0.386 |
|
| 2017 |
Aguirre AJ, Carter S, Camarda N, Ghazani A, Nowak J, Silva AD, Brais L, Ragon D, McCabe D, Marini L, Anderka K, Helvie K, Oliver N, Babic A, Shyn P, et al. Abstract 3036: Real-time genomic characterization of metastatic pancreatic cancer to enable precision medicine Cancer Research. 77: 3036-3036. DOI: 10.1158/1538-7445.Am2017-3036 |
0.495 |
|
| 2017 |
Yeerna H, Rangan R, Aguirre A, Kim W, Vazquez F, Weir B, Ghandi M, Tsherniak A, Boehm J, Hahn W, Mesirov J, Tamayo P. Abstract 1555: Pan-cancer patterns of synthetic lethality: statistical modeling of gene dependency profiles Cancer Research. 77: 1555-1555. DOI: 10.1158/1538-7445.Am2017-1555 |
0.376 |
|
| 2016 |
Howard TP, Vazquez F, Tsherniak A, Hong AL, Rinne M, Aguirre AJ, Boehm JS, Hahn WC. Functional Genomic Characterization of Cancer Genomes. Cold Spring Harbor Symposia On Quantitative Biology. PMID 27815544 DOI: 10.1101/Sqb.2016.81.031070 |
0.737 |
|
| 2016 |
Aguirre AJ, Meyers RM, Weir BA, Vazquez F, Zhang CZ, Ben-David U, Cook A, Ha G, Harrington WF, Doshi MB, Kost-Alimova M, Gill S, Xu H, Ali LD, Jiang G, et al. Genomic copy number dictates a gene-independent cell response to CRISPR-Cas9 targeting. Cancer Discovery. PMID 27260156 DOI: 10.1158/2159-8290.Cd-16-0154 |
0.493 |
|
| 2016 |
Kim JW, Botvinnik OB, Abudayyeh O, Birger C, Rosenbluh J, Shrestha Y, Abazeed ME, Hammerman PS, DiCara D, Konieczkowski DJ, Johannessen CM, Liberzon A, Alizad-Rahvar AR, Alexe G, Aguirre A, et al. Characterizing genomic alterations in cancer by complementary functional associations. Nature Biotechnology. PMID 27088724 DOI: 10.1038/Nbt.3527 |
0.604 |
|
| 2016 |
Raghavan S, Gill S, Aguirre AJ, Tseng YM, Peng A, Keskula P, Wu X, Oh C, Cheah J, Kryukov G, Sicinska E, Wolpin BM, Kulke MH, Fuchs CS, Clemons P, et al. Abstract B13: Human pancreatic cancer organoids for functional dependency profiling Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-B13 |
0.504 |
|
| 2016 |
Aguirre AJ, Shao W, Xu H, Weir B, Vazquez F, Meyers R, Zhang C, Doshi M, Cowley GS, Ewachiw T, Rasheed Z, Golub TR, Stegmaier K, Roberts CW, Garraway LA, et al. Abstract PR05: Genome-scale CRISPR-Cas9 screening to identify essential genes and pathways in pancreatic cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-Pr05 |
0.525 |
|
| 2014 |
Helming KC, Wang X, Wilson BG, Vazquez F, Haswell JR, Manchester HE, Kim Y, Kryukov GV, Ghandi M, Aguirre AJ, Jagani Z, Wang Z, Garraway LA, Hahn WC, Roberts CW. ARID1B is a specific vulnerability in ARID1A-mutant cancers. Nature Medicine. 20: 251-4. PMID 24562383 DOI: 10.1038/Nm.3480 |
0.594 |
|
| 2014 |
Helming K, Wang X, Wilson B, Vazquez F, Haswell J, Manchester H, Kim Y, Kryukov GV, Ghandi M, Aguirre AJ, Jagani Z, Wang Z, Garraway L, Hahn W, Roberts C. Abstract LB-126: ARID1B is a specific vulnerability in ARID1A-mutant cancers Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-126 |
0.59 |
|
| 2008 |
Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, et al. Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proceedings of the National Academy of Sciences of the United States of America. 105: 19372-7. PMID 19050074 DOI: 10.1073/Pnas.0809966105 |
0.515 |
|
| 2005 |
Tonon G, Brennan C, Protopopov A, Maulik G, Feng B, Zhang Y, Khatry DB, You MJ, Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Wong KK, Depinho RA. Common and contrasting genomic profiles among the major human lung cancer subtypes. Cold Spring Harbor Symposia On Quantitative Biology. 70: 11-24. PMID 16869734 DOI: 10.1101/Sqb.2005.70.021 |
0.393 |
|
| 2005 |
Tonon G, Wong KK, Maulik G, Brennan C, Feng B, Zhang Y, Khatry DB, Protopopov A, You MJ, Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Depinho RA. High-resolution genomic profiles of human lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 102: 9625-30. PMID 15983384 DOI: 10.1073/Pnas.0504126102 |
0.41 |
|
| 2004 |
Aguirre AJ, Brennan C, Bailey G, Sinha R, Feng B, Leo C, Zhang Y, Zhang J, Gans JD, Bardeesy N, Cauwels C, Cordon-Cardo C, Redston MS, DePinho RA, Chin L. High-resolution characterization of the pancreatic adenocarcinoma genome. Proceedings of the National Academy of Sciences of the United States of America. 101: 9067-72. PMID 15199222 DOI: 10.1073/Pnas.0402932101 |
0.307 |
|
| Show low-probability matches. |