| Year |
Citation |
Score |
| 2019 |
Manz KM, Baxley AG, Zurawski Z, Hamm HE, Grueter BA. Heterosynaptic GABA receptor function within feedforward microcircuits gates glutamatergic transmission in the nucleus accumbens core. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31578230 DOI: 10.1523/Jneurosci.1395-19.2019 |
0.306 |
|
| 2019 |
Hamm HE, Alford ST. Physiological roles for neuromodulation via G GPCRs working through Gβγ-SNARE interaction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31477818 DOI: 10.1038/S41386-019-0497-2 |
0.346 |
|
| 2019 |
Irfan M, Zurawski Z, Hamm H, Bark C, Stanton PK. Disabling Gβγ-SNAP-25 interaction in gene-targeted mice results in enhancement of long-term potentiation at Schaffer collateral-CA1 synapses in the hippocampus. Neuroreport. PMID 31095110 DOI: 10.1097/Wnr.0000000000001258 |
0.309 |
|
| 2019 |
Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, Winder DG, Alford S, Hamm HE. Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes. Science Signaling. 12. PMID 30783011 DOI: 10.1126/Scisignal.Aat8595 |
0.452 |
|
| 2019 |
Yim YY, Betke KM, McDonald WH, Gilsbach R, Chen Y, Hyde K, Wang Q, Hein L, Hamm H. The in vivo specificity of synaptic Gβ and Gγ subunits to the α adrenergic receptor at CNS synapses. Scientific Reports. 9: 1718. PMID 30737458 DOI: 10.1038/S41598-018-37222-1 |
0.442 |
|
| 2019 |
Zurawski Z, Yim YY, Alford S, Hamm HE. The expanding roles and mechanisms of G protein-mediated presynaptic inhibition. The Journal of Biological Chemistry. 294: 1661-1670. PMID 30710014 DOI: 10.1074/Jbc.Tm118.004163 |
0.436 |
|
| 2018 |
Rigg RA, Healy LD, Chu TT, Ngo ATP, Mitrugno A, Zilberman-Rudenko J, Aslan JE, Hinds MT, Vecchiarelli LD, Morgan TK, Gruber A, Temple KJ, Lindsley CW, Duvernay MT, Hamm HE, et al. Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions. Platelets. 1-10. PMID 30560697 DOI: 10.1080/09537104.2017.1406076 |
0.396 |
|
| 2018 |
Yim YY, Zurawski Z, Hamm H. GPCR regulation of secretion. Pharmacology & Therapeutics. PMID 30056056 DOI: 10.1016/J.Pharmthera.2018.07.005 |
0.406 |
|
| 2018 |
Alford S, Hamm H, Rodriguez S, Zurawski Z. Gβγ SNARE Interactions and Their Behavioral Effects. Neurochemical Research. PMID 29752624 DOI: 10.1007/S11064-018-2531-X |
0.359 |
|
| 2018 |
Lokits AD, Indrischek H, Meiler J, Hamm HE, Stadler PF. Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa. Bmc Evolutionary Biology. 18: 51. PMID 29642851 DOI: 10.1186/S12862-018-1147-8 |
0.449 |
|
| 2018 |
Damian M, Pons V, Renault P, M'Kadmi C, Delort B, Hartmann L, Kaya AI, Louet M, Gagne D, Ben Haj Salah K, Denoyelle S, Ferry G, Boutin JA, Wagner R, Fehrentz JA, ... ... Hamm HE, et al. GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29632174 DOI: 10.1073/Pnas.1712725115 |
0.421 |
|
| 2018 |
Kaiser A, Hempel C, Wanka L, Schubert M, Hamm HE, Beck-Sickinger AG. G protein pre-assembly rescues efficacy of Wtoggle mutations in neuropeptide Yreceptor. Molecular Pharmacology. PMID 29436493 DOI: 10.1124/Mol.117.110544 |
0.432 |
|
| 2017 |
Schmidt P, Bender BJ, Kaiser A, Gulati K, Scheidt HA, Hamm HE, Meiler J, Beck-Sickinger AG, Huster D. Improved in Vitro Folding of the Y2 G Protein-Coupled Receptor into Bicelles. Frontiers in Molecular Biosciences. 4: 100. PMID 29387686 DOI: 10.3389/Fmolb.2017.00100 |
0.426 |
|
| 2017 |
Yim YY, McDonald WH, Hyde K, Cruz-Rodríguez O, Tesmer JJG, Hamm HE. Quantitative multiple reaction monitoring proteomic analysis of Gβ and Gγ subunits in C57Bl6/J brain synaptosomes. Biochemistry. PMID 28880079 DOI: 10.1021/Acs.Biochem.7B00433 |
0.396 |
|
| 2017 |
Zurawski Z, Page B, Chicka MC, Brindley RL, Wells CA, Preininger AM, Hyde K, Gilbert JA, Cruz-Rodriguez O, Currie KPM, Chapman ER, Alford S, Hamm HE. Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes. The Journal of Biological Chemistry. PMID 28515322 DOI: 10.1074/Jbc.M116.773523 |
0.361 |
|
| 2017 |
Van Hook MJ, Babai N, Zurawski Z, Young Yim Y, Hamm HE, Thoreson WB. A presynaptic group III mGluR recruits Gβγ/SNARE interactions to inhibit synaptic transmission by cone photoreceptors in the vertebrate retina. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28363980 DOI: 10.1523/Jneurosci.2948-16.2017 |
0.346 |
|
| 2016 |
Duvernay MT, Temple KJ, Maeng JG, Blobaum AL, Stauffer SR, Lindsley CW, Hamm HE. Contributions of PAR1 and PAR4 to thrombin induced GPIIbIIIa activation in human platelets. Molecular Pharmacology. PMID 27784794 DOI: 10.1124/Mol.116.106666 |
0.413 |
|
| 2016 |
Temple KJ, Duvernay MT, Maeng JG, Blobaum AL, Stauffer SR, Hamm HE, Lindsley CW. Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles. Bioorganic & Medicinal Chemistry Letters. PMID 27777004 DOI: 10.1016/J.Bmcl.2016.10.020 |
0.308 |
|
| 2016 |
Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE. A conserved hydrophobic core in Gαi1 regulates G protein activation and release from activated receptor. The Journal of Biological Chemistry. PMID 27462082 DOI: 10.1074/Jbc.M116.745513 |
0.442 |
|
| 2016 |
Oliver KH, Duvernay MT, Hamm HE, Carneiro AM. Loss of Serotonin Transporter Function Alters ADP-Mediated Integrin αIIb/β3 Activation Through Dysregulation of the 5-HT2A Receptor. The Journal of Biological Chemistry. PMID 27422820 DOI: 10.1074/Jbc.M116.736983 |
0.37 |
|
| 2016 |
Gupta A, Gomes I, Bobeck EN, Fakira AK, Massaro NP, Sharma I, Cavé A, Hamm HE, Parello J, Devi LA. Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 27162327 DOI: 10.1073/Pnas.1521825113 |
0.344 |
|
| 2015 |
Zurawski Z, Rodriguez S, Hyde K, Alford S, Hamm HE. Gβγ binds to the extreme C-terminus of SNAP25 to mediate the action of Gi/o-coupled GPCRs. Molecular Pharmacology. PMID 26519224 DOI: 10.1124/Mol.115.101600 |
0.423 |
|
| 2015 |
Duvernay MT, Matafonov A, Lindsley CW, Hamm HE. Platelet Lipidomic Profiling: Novel Insight into Cytosolic Phospholipase A2α Activity and Its Role in Human Platelet Activation. Biochemistry. 54: 5578-88. PMID 26295742 DOI: 10.1021/Acs.Biochem.5B00549 |
0.414 |
|
| 2015 |
Yim YY, Betke K, Hamm H. Using peptide arrays created by the SPOT method for defining protein-protein interactions. Methods of Molecular Biology. 1278: 307-320. PMID 25859957 DOI: 10.1007/978-1-4939-2425-7_18 |
0.37 |
|
| 2015 |
Kaya AI, Iverson TM, Hamm HE. Functional stability of rhodopsin in a bicelle system: evaluating G protein activation by rhodopsin in bicelles. Methods in Molecular Biology (Clifton, N.J.). 1271: 67-76. PMID 25697517 DOI: 10.1007/978-1-4939-2330-4_5 |
0.464 |
|
| 2014 |
Jacobson R, Mignemi N, Rose K, O'Rear L, Sarilla S, Hamm HE, Barnett JV, Verhamme IM, Schoenecker J. The hyperglycemic byproduct methylglyoxal impairs anticoagulant activity through covalent adduction of antithrombin III. Thrombosis Research. 134: 1350-7. PMID 25307422 DOI: 10.1016/J.Thromres.2014.09.038 |
0.352 |
|
| 2014 |
Wen W, Young SE, Duvernay MT, Schulte ML, Nance KD, Melancon BJ, Engers J, Locuson CW, Wood MR, Daniels JS, Wu W, Lindsley CW, Hamm HE, Stauffer SR. Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354. Bioorganic & Medicinal Chemistry Letters. 24: 4708-13. PMID 25176330 DOI: 10.1016/J.Bmcl.2014.08.021 |
0.324 |
|
| 2014 |
Cleator JH, Duvernay MT, Holinstat M, Colowick NE, Hudson WJ, Song Y, Harrell FE, Hamm HE. Racial differences in resistance to P2Y12receptor antagonists in type 2 diabetic subjects Journal of Pharmacology and Experimental Therapeutics. 351: 33-43. PMID 25052834 DOI: 10.1124/Jpet.114.215616 |
0.601 |
|
| 2014 |
Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE. A conserved phenylalanine as a relay between the α5 helix and the GDP binding region of heterotrimeric Gi protein α subunit. The Journal of Biological Chemistry. 289: 24475-87. PMID 25037222 DOI: 10.1074/Jbc.M114.572875 |
0.37 |
|
| 2014 |
Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM. A transient interaction between the phosphate binding loop and switch i contributes to the allosteric network between receptor and nucleotide in Gαi1 Journal of Biological Chemistry. 289: 11331-11341. PMID 24596087 DOI: 10.1074/Jbc.M113.539064 |
0.389 |
|
| 2014 |
Betke KM, Rose KL, Friedman DB, Baucum AJ, Hyde K, Schey KL, Hamm HE. Differential localization of G protein βγ subunits. Biochemistry. 53: 2329-43. PMID 24568373 DOI: 10.1021/Bi500091P |
0.342 |
|
| 2014 |
Hamid E, Church E, Wells CA, Zurawski Z, Hamm HE, Alford S. Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 260-74. PMID 24381287 DOI: 10.1523/Jneurosci.3633-12.2014 |
0.368 |
|
| 2014 |
Alexander NS, Preininger AM, Kaya AI, Stein RA, Hamm HE, Meiler J. Energetic analysis of the rhodopsin-G-protein complex links the α5 helix to GDP release. Nature Structural & Molecular Biology. 21: 56-63. PMID 24292645 DOI: 10.1038/Nsmb.2705 |
0.442 |
|
| 2013 |
Li X, Roszko I, Sepich DS, Ni M, Hamm HE, Marlow FL, Solnica-Krezel L. Gpr125 modulates Dishevelled distribution and planar cell polarity signaling Development (Cambridge). 140: 3028-3039. PMID 23821037 DOI: 10.1242/Dev.094839 |
0.337 |
|
| 2013 |
Young SE, Duvernay MT, Schulte ML, Lindsley CW, Hamm HE. Synthesis of indole derived protease-activated receptor 4 antagonists and characterization in human platelets. Plos One. 8: e65528. PMID 23776495 DOI: 10.1371/Journal.Pone.0065528 |
0.363 |
|
| 2013 |
Preininger AM, Meiler J, Hamm HE. Conformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspective. Journal of Molecular Biology. 425: 2288-98. PMID 23602809 DOI: 10.1016/J.Jmb.2013.04.011 |
0.437 |
|
| 2013 |
Hamm HE, Kaya AI, Gilbert JA, Preininger AM. Linking receptor activation to changes in Sw I and II of Gα proteins Journal of Structural Biology. 184: 63-74. PMID 23466875 DOI: 10.1016/J.Jsb.2013.02.016 |
0.431 |
|
| 2013 |
Duvernay M, Young S, Gailani D, Schoenecker J, Hamm HE, Hamm H. Protease-activated receptor (PAR) 1 and PAR4 differentially regulate factor V expression from human platelets. Molecular Pharmacology. 83: 781-92. PMID 23307185 DOI: 10.1124/Mol.112.083477 |
0.385 |
|
| 2013 |
Natarajan C, Hata AN, Hamm HE, Zent R, Breyer RM. Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor Molecular Pharmacology. 83: 206-216. PMID 23087260 DOI: 10.1124/Mol.112.080473 |
0.403 |
|
| 2013 |
Holinstat M, Colowick NE, Hudson WJ, Blakemore D, Chen Q, Hamm HE, Cleator JH. Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation Journal of Thrombosis and Thrombolysis. 35: 209-222. PMID 23054462 DOI: 10.1007/S11239-012-0812-9 |
0.634 |
|
| 2013 |
Duvernay MT, Hamm H. Platelet Microparticle Production Is Regulated By STIM1 Dependent Entry Of Extracellular Ca2+ Through Orai1 Blood. 122: 1059-1059. DOI: 10.1182/Blood.V122.21.1059.1059 |
0.391 |
|
| 2012 |
Wells CA, Zurawski Z, Betke KM, Yim YY, Hyde K, Rodriguez S, Alford S, Hamm HE. Gβγ inhibits exocytosis via interaction with critical residues on soluble N-ethylmaleimide-sensitive factor attachment protein-25. Molecular Pharmacology. 82: 1136-49. PMID 22962332 DOI: 10.1124/Mol.112.080507 |
0.439 |
|
| 2012 |
Wells CA, Betke KM, Lindsley CW, Hamm HE. Label-free detection of G protein-SNARE interactions and screening for small molecule modulators. Acs Chemical Neuroscience. 3: 69-78. PMID 22368765 DOI: 10.1021/Cn200102D |
0.374 |
|
| 2012 |
Preininger AM, Kaya AI, Gilbert JA, Busenlehner LS, Armstrong RN, Hamm HE. Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution. Biochemistry. 51: 1911-24. PMID 22329346 DOI: 10.1021/Bi201472C |
0.482 |
|
| 2012 |
Betke KM, Wells CA, Hamm HE. GPCR mediated regulation of synaptic transmission Progress in Neurobiology. 96: 304-321. PMID 22307060 DOI: 10.1016/J.Pneurobio.2012.01.009 |
0.352 |
|
| 2012 |
Thaker TM, Kaya AI, Preininger AM, Hamm HE, Iverson TM. Allosteric mechanisms of G protein-coupled receptor signaling: A structural perspective Methods in Molecular Biology. 796: 133-174. PMID 22052489 DOI: 10.1007/978-1-61779-334-9_8 |
0.457 |
|
| 2012 |
Ichikawa J, Cole HA, Magnussen RA, Mignemi NA, Butler M, Holt GE, O'Rear L, Yuasa M, Pabla B, Haro H, Cates JMM, Hamm HE, Schwartz HS, Schoenecker JG. Thrombin induces osteosarcoma growth, a function inhibited by low molecular weight heparin in vitro and in vivo: Procoagulant nature of osteosarcoma Cancer. 118: 2494-2506. PMID 21953059 DOI: 10.1002/Cncr.26518 |
0.302 |
|
| 2012 |
Thaker TM, Kaya AI, Preininger AM, Hamm HE, Iverson T. Molecular Determinants of GPCR-G Protein Complex Formation Biophysical Journal. 102: 31a-32a. DOI: 10.1016/J.Bpj.2011.11.200 |
0.418 |
|
| 2011 |
Van Eps N, Preininger AM, Alexander N, Kaya AI, Meier S, Meiler J, Hamm HE, Hubbell WL. Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit. Proceedings of the National Academy of Sciences of the United States of America. 108: 9420-4. PMID 21606326 DOI: 10.1073/Pnas.1105810108 |
0.457 |
|
| 2011 |
Kaya AI, Thaker TM, Preininger AM, Iverson TM, Hamm HE. Coupling efficiency of rhodopsin and transducin in bicelles Biochemistry. 50: 3193-3203. PMID 21375271 DOI: 10.1021/Bi200037J |
0.479 |
|
| 2011 |
Lenoci L, Duvernay M, Satchell S, DiBenedetto E, Hamm HE. Mathematical model of PAR1-mediated activation of human platelets Molecular Biosystems. 7: 1129-1137. PMID 21229145 DOI: 10.1039/C0Mb00250J |
0.382 |
|
| 2011 |
Holinstat M, Boutaud O, Apopa PL, Vesci J, Bala M, Oates JA, Hamm HE. Protease-activated receptor signaling in platelets activates cytosolic phospholipase a2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 435-442. PMID 21127289 DOI: 10.1161/Atvbaha.110.219527 |
0.646 |
|
| 2011 |
Duvernay MT, Young SE, Gailani D, Schoenecker JG, Hamm H. Coagulation Cofactor Presentation and Complex Assembly on Platelets by Protease Activated Receptors (PARs): PAR4 Stimulation Leads to More FV and FVIII and More Thrombin Generation Than PAR1 Blood. 118: 1135-1135. DOI: 10.1182/Blood.V118.21.1135.1135 |
0.364 |
|
| 2010 |
Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E. Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity. Science Signaling. 3: ra37. PMID 20460648 DOI: 10.1126/Scisignal.2000647 |
0.408 |
|
| 2010 |
Shen L, Caruso G, Bisegna P, Andreucci D, Gurevich VV, Hamm HE, DiBenedetto E. Dynamics of mouse rod phototransduction and its sensitivity to variation of key parameters Iet Systems Biology. 4: 12-32. PMID 20001089 DOI: 10.1049/Iet-Syb.2008.0154 |
0.335 |
|
| 2010 |
Li X, Hamm H, Solnica-Krezel L. Studying the potential dual role of adhesion G protein-coupled receptors in early zebrafish embryogenesis Developmental Biology. 344: 449. DOI: 10.1016/J.Ydbio.2010.05.151 |
0.408 |
|
| 2009 |
Marjoram RJ, Voss B, Pan Y, Dickeson SK, Zutter MM, Hamm HE, Santoro SA. Suboptimal activation of protease-activated receptors enhances α 2β1 integrin-mediated platelet adhesion tocollagen Journal of Biological Chemistry. 284: 34640-34647. PMID 19815553 DOI: 10.1074/Jbc.M109.020990 |
0.441 |
|
| 2009 |
Hamm HE, Meier SM, Liao G, Preininger AM. Trp fluorescence reveals an activation-dependent cation-π interaction in the switch II region of Gαi proteins Protein Science. 18: 2326-2335. PMID 19760664 DOI: 10.1002/Pro.243 |
0.38 |
|
| 2009 |
Holinstat M, Preininger AM, Milne SB, Hudson WJ, Brown HA, Hamm HE. Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates Molecular Pharmacology. 76: 301-313. PMID 19483102 DOI: 10.1124/Mol.109.056622 |
0.636 |
|
| 2009 |
Preininger AM, Funk MA, Oldham WM, Meier SM, Johnston CA, Adhikary S, Kimple AJ, Siderovski DP, Hamm HE, Iverson TM. Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits. Biochemistry. 48: 2630-42. PMID 19222191 DOI: 10.1021/Bi801853A |
0.417 |
|
| 2009 |
Holinstat M, Voss B, Bilodeau ML, Hamm HE. Erratum: Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway (Molecular Pharmacology (2007) 71 (686-694)) Molecular Pharmacology. 75: 730-731. DOI: 10.1124/Mol.75.3.730 |
0.647 |
|
| 2009 |
DiBenedetto E, Bisegna P, Caruso G, Shen L, Andreucci D, Gurevich V, Hamm HE. Mathematical aspects of Variability and Variability Suppression of the Single Photon Response in Vertebrate Phototransduction Biophysical Journal. 96: 200a. DOI: 10.1016/J.Bpj.2008.12.1073 |
0.34 |
|
| 2008 |
Yoon EJ, Hamm HE, Currie KPM. G protein βγ subunits modulate the number and nature of exocytotic fusion events in adrenal chromaffin cells independent of calcium entry Journal of Neurophysiology. 100: 2929-2939. PMID 18815342 DOI: 10.1152/Jn.90839.2008 |
0.365 |
|
| 2008 |
Preininger AM, Parello J, Meier SM, Liao G, Hamm HE. Receptor-mediated changes at the myristoylated amino terminus of Gαil proteins Biochemistry. 47: 10281-10293. PMID 18771287 DOI: 10.1021/Bi800741R |
0.472 |
|
| 2008 |
Chen S, Lin F, Myung ES, Wang F, Shen L, Hamm HE. RACK1 regulates directional cell migration by acting on gβγ at the interface with its effectors PLCβ and PI3Kγ Molecular Biology of the Cell. 19: 3909-3922. PMID 18596232 DOI: 10.1091/Mbc.E08-04-0433 |
0.466 |
|
| 2008 |
Bisegna P, Caruso G, Andreucci D, Shen L, Gurevich VV, Hamm HE, Dibenedetto E. Diffusion of the second messengers in the cytoplasm acts as a variability suppressor of the single photon response in vertebrate phototransduction Biophysical Journal. 94: 3363-3383. PMID 18400950 DOI: 10.1529/Biophysj.107.114058 |
0.312 |
|
| 2008 |
Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors Nature Reviews Molecular Cell Biology. 9: 60-71. PMID 18043707 DOI: 10.1038/Nrm2299 |
0.498 |
|
| 2007 |
Oldham WM, Hamm HE. How do Receptors Activate G Proteins? Advances in Protein Chemistry. 74: 67-93. PMID 17854655 DOI: 10.1016/S0065-3233(07)74002-0 |
0.484 |
|
| 2007 |
Yoon EJ, Gerachshenko T, Spiegelberg BD, Alford S, Hamm HE. Gbetagamma interferes with Ca2+-dependent binding of synaptotagmin to the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex. Molecular Pharmacology. 72: 1210-9. PMID 17715396 DOI: 10.1124/Mol.107.039446 |
0.374 |
|
| 2007 |
Bilodeau ML, Hamm HE. Regulation of protease-activated receptor (PAR) 1 and PAR4 signaling in human platelets by compartmentalized cyclic nucleotide actions. The Journal of Pharmacology and Experimental Therapeutics. 322: 778-88. PMID 17525299 DOI: 10.1124/Jpet.107.121830 |
0.454 |
|
| 2007 |
Oldham WM, Van Eps N, Preininger AM, Hubbell WL, Hamm HE. Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins. Proceedings of the National Academy of Sciences of the United States of America. 104: 7927-32. PMID 17463080 DOI: 10.1073/Pnas.0702623104 |
0.45 |
|
| 2007 |
Voss B, McLaughlin JN, Holinstat M, Zent R, Hamm HE. PAR1, but not PAR4, activates human platelets through a G i/o/phosphoinositide-3 kinase signaling axis Molecular Pharmacology. 71: 1399-1406. PMID 17303701 DOI: 10.1124/Mol.106.033365 |
0.658 |
|
| 2007 |
Spiegelberg BD, Hamm HE. Roles of G-protein-coupled receptor signaling in cancer biology and gene transcription Current Opinion in Genetics and Development. 17: 40-44. PMID 17188489 DOI: 10.1016/J.Gde.2006.12.002 |
0.424 |
|
| 2007 |
Holinstat M, Voss B, Bilodeau ML, Hamm HE. Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway. Molecular Pharmacology. 71: 686-94. PMID 17151288 DOI: 10.1124/Mol.106.029371 |
0.653 |
|
| 2007 |
Holinstat M, Hudson WJ, Preininger AM, Hamm HE. Irreversible Platelet Activation Requires PAR1 Regulation of Phosphatidylinositol Phosphates (PIPns) Activation of Rap1. Blood. 110: 3889-3889. DOI: 10.1182/Blood.V110.11.3889.3889 |
0.626 |
|
| 2007 |
Chen S, Lin F, Shin M, Wang F, Hamm HE. Regulation of heterotrimeric G protein βγ subunits mediated PI3K activation and leukocyte migration through a novel WD40‐WD40 repeat interaction between RACK1 and Gβγ The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A616-C |
0.465 |
|
| 2007 |
Funk MA, Oldham WM, Preininger AM, Hamm HE, Iverson TM. The crystal structure of the fast exchange mutant I56C/Q333C in Gα
i1
suggests a mechanism for receptor‐mediated allosteric nucleotide exchange The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A613 |
0.39 |
|
| 2007 |
Holinstat M, Hudson WJ, Voss B, Hamm HE. PI‐3K differentially regulates protease activated receptor‐mediated platelet activation in humans through Rap1 The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A603-B |
0.621 |
|
| 2006 |
Murphy SC, Harrison T, Hamm HE, Lomasney JW, Mohandas N, Haldar K. Erythrocyte G protein as a novel target for malarial chemotherapy. Plos Medicine. 3: e528. PMID 17194200 DOI: 10.1371/Journal.Pmed.0030528 |
0.367 |
|
| 2006 |
Van Eps N, Oldham WM, Hamm HE, Hubbell WL. Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway. Proceedings of the National Academy of Sciences of the United States of America. 103: 16194-9. PMID 17053066 DOI: 10.1073/Pnas.0607972103 |
0.435 |
|
| 2006 |
Chen S, Hamm HE. DEP Domains: More Than Just Membrane Anchors Developmental Cell. 11: 436-438. PMID 17011483 DOI: 10.1016/J.Devcel.2006.09.011 |
0.408 |
|
| 2006 |
Oldham WM, Hamm HE. Structural basis of function in heterotrimeric G proteins Quarterly Reviews of Biophysics. 39: 117-166. PMID 16923326 DOI: 10.1017/S0033583506004306 |
0.477 |
|
| 2006 |
Holinstat M, Oldham WM, Hamm HE. G-protein-coupled receptors: Evolving views on physiological signalling: Symposium on G-Protein-Coupled Receptors: Evolving Concepts and New Techniques Embo Reports. 7: 866-869. PMID 16906127 DOI: 10.1038/Sj.Embor.7400788 |
0.656 |
|
| 2006 |
Oldham WM, Van Eps N, Preininger AM, Hubbell WL, Hamm HE. Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Nature Structural & Molecular Biology. 13: 772-7. PMID 16892066 DOI: 10.1038/Nsmb1129 |
0.448 |
|
| 2006 |
Holinstat M, Voss B, Bilodeau ML, McLaughlin JN, Cleator J, Hamm HE. PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation. The Journal of Biological Chemistry. 281: 26665-74. PMID 16837456 DOI: 10.1074/Jbc.M602174200 |
0.647 |
|
| 2006 |
Preininger AM, Henage LG, Oldham WM, Yoon EJ, Hamm HE, Brown HA. Direct modulation of phospholipase D activity by Gβγ Molecular Pharmacology. 70: 311-318. PMID 16638972 DOI: 10.1124/Mol.105.021451 |
0.372 |
|
| 2006 |
Bilodeau ML, Hamm HE. Endothelial nitric-oxide synthase reveals a new face in G protein signaling. Molecular Pharmacology. 69: 677-9. PMID 16377762 DOI: 10.1124/Mol.105.022038 |
0.415 |
|
| 2006 |
Cleator JH, Zhu WQ, Vaughan DE, Hamm HE. Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP. Blood. 107: 2736-44. PMID 16332977 DOI: 10.1182/Blood-2004-07-2698 |
0.325 |
|
| 2006 |
Georgoussi Z, Leontiadis L, Mazarakou G, Merkouris M, Hyde K, Hamm H. Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the μ- and δ-opioid receptors regulate opioid receptor signaling Cellular Signalling. 18: 771-782. PMID 16120478 DOI: 10.1016/J.Cellsig.2005.07.003 |
0.407 |
|
| 2006 |
Holinstat M, Hamm HE. Protease Activated Receptors Differentially Regulate Human Platelet Activation through Phosphatidic Acid-Dependent DAG Formation. Blood. 108: 3906-3906. DOI: 10.1182/Blood.V108.11.3906.3906 |
0.65 |
|
| 2005 |
Spiegelberg BD, Hamm HE. Gβγ binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity Journal of Biological Chemistry. 280: 41769-41776. PMID 16221676 DOI: 10.1074/Jbc.M504066200 |
0.441 |
|
| 2005 |
Chen S, Lin F, Hamm HE. RACK1 binds to a signal transfer region of Gβγ and inhibits phospholipase C β2 activation Journal of Biological Chemistry. 280: 33445-33452. PMID 16051595 DOI: 10.1074/Jbc.M505422200 |
0.434 |
|
| 2005 |
Lin F, Sepich DS, Chen S, Topczewski J, Yin C, Solnica-Krezel L, Hamm H. Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements. The Journal of Cell Biology. 169: 777-87. PMID 15928205 DOI: 10.1083/Jcb.200501104 |
0.326 |
|
| 2005 |
Lukov GL, Hu T, McLaughlin JN, Hamm HE, Willardson BM. Phosducin-like protein acts as a molecular chaperone for G protein βγ dimer assembly Embo Journal. 24: 1965-1975. PMID 15889144 DOI: 10.1038/Sj.Emboj.7600673 |
0.431 |
|
| 2005 |
McLaughlin JN, Shen L, Holinstat M, Brooks JD, DiBenedetto E, Hamm HE. Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1 Journal of Biological Chemistry. 280: 25048-25059. PMID 15878870 DOI: 10.1074/Jbc.M414090200 |
0.661 |
|
| 2005 |
Gerachshenko T, Blackmer T, Yoon EJ, Bartleson C, Hamm HE, Alford S. Gbetagamma acts at the C terminus of SNAP-25 to mediate presynaptic inhibition. Nature Neuroscience. 8: 597-605. PMID 15834421 DOI: 10.1038/Nn1439 |
0.419 |
|
| 2005 |
McLaughlin JN, Mazzoni MR, Cleator JH, Earls L, Perdigoto AL, Brooks JD, Muldowney JA, Vaughan DE, Hamm HE. Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells. The Journal of Biological Chemistry. 280: 22172-80. PMID 15817447 DOI: 10.1074/Jbc.M500721200 |
0.375 |
|
| 2005 |
Blackmer T, Larsen EC, Bartleson C, Kowalchyk JA, Yoon EJ, Preininger AM, Alford S, Hamm HE, Martin TF. G protein betagamma directly regulates SNARE protein fusion machinery for secretory granule exocytosis. Nature Neuroscience. 8: 421-5. PMID 15778713 DOI: 10.1038/Nn1423 |
0.408 |
|
| 2004 |
Cabrera-Vera TM, Hernandez S, Earls LR, Medkova M, Sundgren-Andersson AK, Surmeier DJ, Hamm HE. RGS9-2 modulates D2 dopamine receptor-mediated Ca2+ channel inhibition in rat striatal cholinergic interneurons. Proceedings of the National Academy of Sciences of the United States of America. 101: 16339-44. PMID 15534226 DOI: 10.1073/Pnas.0407416101 |
0.387 |
|
| 2004 |
Chen S, Spiegelberg BD, Lin F, Dell EJ, Hamm HE. Interaction of Gβγ with RACK1 and other WD40 repeat proteins Journal of Molecular and Cellular Cardiology. 37: 399-406. PMID 15276010 DOI: 10.1016/J.Yjmcc.2004.04.019 |
0.433 |
|
| 2004 |
Chen S, Dell EJ, Lin F, Sai J, Hamm HE. RACK1 Regulates Specific Functions of Gβγ Journal of Biological Chemistry. 279: 17861-17868. PMID 14963031 DOI: 10.1074/Jbc.M313727200 |
0.511 |
|
| 2004 |
Preininger AM, Hamm HE. G protein signaling: insights from new structures. Science's Stke : Signal Transduction Knowledge Environment. 2004: re3. PMID 14762218 DOI: 10.1126/Stke.2182004Re3 |
0.432 |
|
| 2004 |
Preininger AM, Hamm HE. Heterotrimeric G Protein Cycle Science Signaling. 2004: tr1-tr1. DOI: 10.1126/Stke.2182004Tr1 |
0.458 |
|
| 2004 |
Cleator JH, Vaughan DE, Hamm HE. 1064-181 Distinct signaling pathways mediate protease activated receptor-dependent endothelial exocytosis Journal of the American College of Cardiology. 43: A465. DOI: 10.1016/S0735-1097(04)91968-7 |
0.383 |
|
| 2003 |
Cabrera-Vera TM, Vanhauwe J, Thomas TO, Medkova M, Preininger A, Mazzoni MR, Hamm HE. Insights into G Protein Structure, Function, and Regulation Endocrine Reviews. 24: 765-781. PMID 14671004 DOI: 10.1210/Er.2000-0026 |
0.471 |
|
| 2003 |
Slessareva JE, Ma H, Depree KM, Flood LA, Bae H, Cabrera-Vera TM, Hamm HE, Graber SG. Closely Related G-protein-coupled Receptors Use Multiple and Distinct Domains on G-protein α-Subunits for Selective Coupling Journal of Biological Chemistry. 278: 50530-50536. PMID 14525988 DOI: 10.1074/Jbc.M304417200 |
0.333 |
|
| 2003 |
Harrison T, Samuel BU, Akompong T, Hamm H, Mohandas N, Lomasney JW, Haldar K. Erythrocyte G protein-coupled receptor signaling in malarial infection. Science (New York, N.Y.). 301: 1734-6. PMID 14500986 DOI: 10.1126/Science.1089324 |
0.374 |
|
| 2003 |
Preininger AM, Van Eps N, Yu NJ, Medkova M, Hubbell WL, Hamm HE. The myristoylated amino terminus of Galpha(i)(1) plays a critical role in the structure and function of Galpha(i)(1) subunits in solution. Biochemistry. 42: 7931-41. PMID 12834345 DOI: 10.1021/Bi0345438 |
0.35 |
|
| 2003 |
Chen NF, Yu JZ, Skiba NP, Hamm HE, Rasenick MM. A specific domain of Giα required for the transactivation of Giα by tubulin is implicated in the organization of cellular microtubules Journal of Biological Chemistry. 278: 15285-15290. PMID 12582171 DOI: 10.1074/Jbc.M300841200 |
0.373 |
|
| 2002 |
Dell EJ, Connor J, Chen S, Stebbins EG, Skiba NP, Moehly-Rosen D, Hamm HE. The βγ subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins Journal of Biological Chemistry. 277: 49888-49895. PMID 12359736 DOI: 10.1074/Jbc.M202755200 |
0.308 |
|
| 2002 |
Medkova M, Preininger AM, Yu NJ, Hubbell WL, Hamm HE. Conformational changes in the amino-terminal helix of the G protein alpha(i1) following dissociation from Gbetagamma subunit and activation. Biochemistry. 41: 9962-72. PMID 12146960 DOI: 10.1021/Bi0255726 |
0.447 |
|
| 2002 |
Vanhauwe JF, Thomas TO, Minshall RD, Tiruppathi C, Li A, Gilchrist A, Yoon EJ, Malik AB, Hamm HE. Thrombin receptors activate G(o) proteins in endothelial cells to regulate intracellular calcium and cell shape changes. The Journal of Biological Chemistry. 277: 34143-9. PMID 12039967 DOI: 10.1074/Jbc.M204477200 |
0.559 |
|
| 2002 |
Mukherjee S, Gurevich VV, Preninger A, Hamm HE, Bader MF, Fazleabas AT, Birnbaumer L, Hunzicker-Dunn M. Aspartic acid 564 in the third cytoplasmic loop of the luteinizing hormone/choriogonadotropin receptor is crucial for phosphorylation-independent interaction with arrestin2. The Journal of Biological Chemistry. 277: 17916-27. PMID 11867621 DOI: 10.1074/Jbc.M110479200 |
0.377 |
|
| 2002 |
Gilchrist A, Li A, Hamm HE. G alpha COOH-terminal minigene vectors dissect heterotrimeric G protein signaling. Science's Stke : Signal Transduction Knowledge Environment. 2002: pl1. PMID 11836477 DOI: 10.1126/Stke.2002.118.Pl1 |
0.472 |
|
| 2002 |
Schey KL, Busman M, Cook LA, Hamm HE, Hildebrandt JD. Structural characterization of intact G protein gamma subunits by mass spectrometry. Methods in Enzymology. 344: 586-97. PMID 11771413 DOI: 10.1016/S0076-6879(02)44742-8 |
0.366 |
|
| 2002 |
Gilchrist A, Li A, Hamm HE. Design and use of C-terminal minigene vectors for studying role of heterotrimeric G proteins. Methods in Enzymology. 344: 58-69. PMID 11771412 DOI: 10.1016/S0076-6879(02)44705-2 |
0.339 |
|
| 2002 |
Dell EJ, Blackmer T, Skiba NP, Daaka Y, Shekter LR, Rosal R, Reuveny E, Hamm HE. Defining G protein beta gamma specificity for effector recognition. Methods in Enzymology. 344: 421-34. PMID 11771401 DOI: 10.1016/S0076-6879(02)44731-3 |
0.351 |
|
| 2001 |
Cabrera-Vera TM, Thomas TO, Vanhauwe J, Depree KM, Graber SG, Hamm HE. Dissecting receptor-G protein specificity using Gα chimeras Methods in Enzymology. 344: 69-81. PMID 11771421 DOI: 10.1016/S0076-6879(02)44706-4 |
0.474 |
|
| 2001 |
Thomas TO, Bae H, Medkova M, Hamm HE. An intramolecular contact in Gα transducin that participates in maintaining its intrinsic GDP release rate Molecular Cell Biology Research Communications. 4: 282-291. PMID 11529678 DOI: 10.1006/Mcbr.2001.0293 |
0.356 |
|
| 2001 |
Salvador LM, Mukherjee S, Kahn RA, Lamm MLG, Fazleabas AT, Maizels ET, Bader MF, Hamm H, Rasenick MM, Casanova JE, Hunzieker-Dunn M. Activation of the Luteinizing Hormone/Choriogonadotropin Hormone Receptor Promotes ADP Ribosylation Factor 6 Activation in Porcine Ovarian Follicular Membranes Journal of Biological Chemistry. 276: 33773-33781. PMID 11448949 DOI: 10.1074/Jbc.M101498200 |
0.406 |
|
| 2001 |
Minadeo N, Layden B, Amari LV, Thomas V, Radloff K, Srinivasan C, Hamm HE, de Freitas DM. Effect of Li+ upon the Mg2+-dependent activation of recombinant Gialpha1. Archives of Biochemistry and Biophysics. 388: 7-12. PMID 11361143 DOI: 10.1006/Abbi.2001.2282 |
0.432 |
|
| 2001 |
Thulin CD, Savage JR, McLaughlin JN, Truscott SM, Old WM, Ahn NG, Resing KA, Hamm HE, Bitensky MW, Willardson BM. Modulation of the G Protein Regulator Phosducin by Ca 2+/Calmodulin-dependent Protein Kinase II Phosphorylation and 14-3-3 Protein Binding Journal of Biological Chemistry. 276: 23805-23815. PMID 11331285 DOI: 10.1074/Jbc.M101482200 |
0.303 |
|
| 2001 |
Hamm HE. How activated receptors couple to G proteins Proceedings of the National Academy of Sciences of the United States of America. 98: 4819-4821. PMID 11320227 DOI: 10.1073/Pnas.011099798 |
0.448 |
|
| 2001 |
Blackmer T, Larsen EC, Takahashi M, Martin TF, Alford S, Hamm HE. G protein betagamma subunit-mediated presynaptic inhibition: regulation of exocytotic fusion downstream of Ca2+ entry. Science (New York, N.Y.). 292: 293-7. PMID 11303105 DOI: 10.1126/Science.1058803 |
0.399 |
|
| 2001 |
Gilchrist A, Vanhauwe JF, Li A, Thomas TO, Voyno-Yasenetskaya T, Hamm HE. G alpha minigenes expressing C-terminal peptides serve as specific inhibitors of thrombin-mediated endothelial activation. The Journal of Biological Chemistry. 276: 25672-9. PMID 11274183 DOI: 10.1074/Jbc.M100914200 |
0.455 |
|
| 2001 |
Lopez I, Mak EC, Ding J, Hamm HE, Lomasney JW. A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway. The Journal of Biological Chemistry. 276: 2758-65. PMID 11022047 DOI: 10.1074/Jbc.M008119200 |
0.386 |
|
| 2001 |
Aris L, Gilchrist A, Rens-Domiano S, Meyer C, Schatz PJ, Dratz EA, Hamm HE. Structural requirements for the stabilization of metarhodopsin II by the C terminus of the alpha subunit of transducin. The Journal of Biological Chemistry. 276: 2333-9. PMID 11018024 DOI: 10.1074/Jbc.M002533200 |
0.31 |
|
| 2001 |
Wang L, Wang M, Butler K, Gilchrist A, Hamm HE, Valle JD. A dominant negative approach for characterization of the G-proteins mediating histamine H2 receptor signaling Gastroenterology. 120: A20. DOI: 10.1016/S0016-5085(08)80099-6 |
0.402 |
|
| 2000 |
Minshall RD, Tiruppathi C, Vogel SM, Niles WD, Gilchrist A, Hamm HE, Malik AB. Endothelial cell-surface gp60 activates vesicle formation and trafficking via G(i)-coupled Src kinase signaling pathway. The Journal of Cell Biology. 150: 1057-70. PMID 10973995 DOI: 10.1083/Jcb.150.5.1057 |
0.538 |
|
| 2000 |
Savage JR, McLaughlin JN, Skiba NP, Hamm HE, Willardson BM. Functional roles of the two domains of phosducin and phosducin-like protein. The Journal of Biological Chemistry. 275: 30399-407. PMID 10896945 DOI: 10.1074/Jbc.M005120200 |
0.411 |
|
| 2000 |
Mazzoni MR, Taddei S, Giusti L, Rovero P, Galoppini C, D'Ursi A, Albrizio S, Triolo A, Novellino E, Greco G, Lucacchini A, Hamm HE. A Gα(s) carboxyl-terminal peptide prevents G(s) activation by the A(2A) adenosine receptor Molecular Pharmacology. 58: 226-236. PMID 10860945 DOI: 10.1124/Mol.58.1.226 |
0.362 |
|
| 2000 |
Hernández-López S, Tkatch T, Perez-Garci E, Galarraga E, Bargas J, Hamm H, Surmeier DJ. D2Dopamine Receptors in Striatal Medium Spiny Neurons Reduce L-Type Ca2+Currents and Excitability via a Novel PLCβ1–IP3–Calcineurin-Signaling Cascade The Journal of Neuroscience. 20: 8987-8995. DOI: 10.1523/Jneurosci.20-24-08987.2000 |
0.332 |
|
| 2000 |
Thomas TO, Gilchrist A, Li A, Vanhauwe JF, Voyno-Yasenetskaya TA, Tiruppathi C, Hamm HE. Systematic study of dominant negative Gα C-terminal minigenes delineate G protein pathways in thrombin-mediated responses of endothelial cells Biochemical Society Transactions. 28: A470-A470. DOI: 10.1042/Bst028A470A |
0.373 |
|
| 1999 |
Bae H, Cabrera-Vera TM, Depree KM, Graber SG, Hamm HE. Two amino acids within the helix of Gα(i1) mediate coupling with 5- hydroxytryptamine(1B) receptors Journal of Biological Chemistry. 274: 14963-14971. PMID 10329698 DOI: 10.1074/Jbc.274.21.14963 |
0.424 |
|
| 1999 |
Ellis CA, Malik AB, Gilchrist A, Hamm H, Sandoval R, Voyno-Yasenetskaya T, Tiruppathi C. Thrombin induces proteinase-activated receptor-1 gene expression in endothelial cells via activation of Gi-linked Ras/mitogen-activated protein kinase pathway. The Journal of Biological Chemistry. 274: 13718-27. PMID 10224146 DOI: 10.1074/Jbc.274.19.13718 |
0.532 |
|
| 1999 |
Rajagopalan-Gupta RM, Mukherjee S, Zhu X, Ho YK, Hamm H, Birnbaumer M, Birnbaumer L, Hunzicker-Dunn M. Roles of Gi and Gq/11 in mediating desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes. Endocrinology. 140: 1612-21. PMID 10098495 DOI: 10.1210/Endo.140.4.6657 |
0.41 |
|
| 1999 |
Skiba NP, Yang CS, Huang T, Bae H, Hamm HE. The α-helical domain of Gα(t) determines specific interaction with regulator of G protein signaling 9 Journal of Biological Chemistry. 274: 8770-8778. PMID 10085118 DOI: 10.1074/Jbc.274.13.8770 |
0.494 |
|
| 1999 |
Gilchrist A, Bünemann M, Li A, Hosey MM, Hamm HE. A dominant-negative strategy for studying roles of G proteins in vivo. The Journal of Biological Chemistry. 274: 6610-6. PMID 10037756 DOI: 10.1074/Jbc.274.10.6610 |
0.455 |
|
| 1999 |
Yang CS, Skiba NP, Mazzoni MR, Hamm HE. Conformational changes at the carboxyl terminus of Gα occur during G protein activation Journal of Biological Chemistry. 274: 2379-2385. PMID 9891006 DOI: 10.1074/Jbc.274.4.2379 |
0.371 |
|
| 1998 |
Gilchrist A, Mazzoni MR, Dineen B, Dice A, Linden J, Proctor WR, Lupica CR, Dunwiddie TV, Hamm HE. Antagonists of the receptor-G protein interface block Gi-coupled signal transduction. The Journal of Biological Chemistry. 273: 14912-9. PMID 9614095 DOI: 10.1074/Jbc.273.24.14912 |
0.449 |
|
| 1998 |
Ford CE, Skiba NP, Bae H, Daaka Y, Reuveny E, Shekter LR, Rosal R, Weng G, Yang CS, Iyengar R, Miller RJ, Jan LY, Lefkowitz RJ, Hamm HE. Molecular basis for interactions of G protein betagamma subunits with effectors. Science (New York, N.Y.). 280: 1271-4. PMID 9596582 DOI: 10.1126/Science.280.5367.1271 |
0.453 |
|
| 1998 |
Skiba NP, Hamm HE. How Gsα activates adenylyl cyclase Nature Structural Biology. 5: 88-92. PMID 9461067 DOI: 10.1038/Nsb0298-88 |
0.33 |
|
| 1998 |
Hamm HE. The many faces of G protein signaling Journal of Biological Chemistry. 273: 669-672. PMID 9422713 DOI: 10.1074/Jbc.273.2.669 |
0.366 |
|
| 1997 |
Bae H, Anderson K, Flood LA, Skiba NP, Hamm HE, Graber SG. Molecular determinants of selectivity in 5-hydroxytryptamine(1B) receptor-G protein interactions Journal of Biological Chemistry. 272: 32071-32077. PMID 9405403 DOI: 10.1074/Jbc.272.51.32071 |
0.441 |
|
| 1997 |
Nekrasova ER, Berman DM, Rustandi RR, Hamm HE, Gilman AG, Arshavsky VY. Activation of transducin guanosine triphosphatase by two proteins of the RGS family Biochemistry. 36: 7638-7643. PMID 9201904 DOI: 10.1021/Bi970427R |
0.469 |
|
| 1996 |
Mazzoni MR, Hamm HE. Interaction of transducin with light-activated rhodopsin protects it from proteolytic digestion by trypsin Journal of Biological Chemistry. 271: 30034-30040. PMID 8939950 DOI: 10.1074/Jbc.271.47.30034 |
0.383 |
|
| 1996 |
Artemyev NO, Surendran R, Lee JC, Hamm HE. Subunit structure of rod cGMP-phosphodiesterase Journal of Biological Chemistry. 271: 25382-25388. PMID 8810304 DOI: 10.1074/Jbc.271.41.25382 |
0.616 |
|
| 1996 |
Hamm HE, Gilchrist A. Heterotrimeric G proteins. Current Opinion in Cell Biology. 8: 189-96. PMID 8791425 DOI: 10.1016/S0955-0674(96)80065-2 |
0.431 |
|
| 1996 |
Artemyev NO, Natochin M, Busman M, Schey KL, Hamm HE. Mechanism of photoreceptor cGMP phosphodiesterase inhibition by its γ-subunits Proceedings of the National Academy of Sciences of the United States of America. 93: 5407-5412. PMID 8643588 DOI: 10.1073/Pnas.93.11.5407 |
0.632 |
|
| 1996 |
Suh KH, Hamm HE. Cyclic AMP-dependent phosphoprotein components I and II interact with βγ subunits of transducin in frog rod outer segments Biochemistry. 35: 290-298. PMID 8555187 DOI: 10.1021/Bi9518656 |
0.32 |
|
| 1996 |
Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB. Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Nature. 379: 369-74. PMID 8552196 DOI: 10.1038/379369A0 |
0.388 |
|
| 1996 |
Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB. The 2.0 A crystal structure of a heterotrimeric G protein. Nature. 379: 311-9. PMID 8552184 DOI: 10.1038/379311A0 |
0.446 |
|
| 1996 |
Skiba NP, Bae H, Hamm HE. Mapping of effector binding sites of transducin α-subunit using Gαt/Gαi1 chimeras Journal of Biological Chemistry. 271: 413-424. PMID 8550597 DOI: 10.1074/Jbc.271.1.413 |
0.39 |
|
| 1996 |
Martin EL, Rens-Domiano S, Schatz PJ, Hamm HE. Potent peptide analogues of a G protein receptor-binding region obtained with a combinatorial library Journal of Biological Chemistry. 271: 361-366. PMID 8550587 DOI: 10.1074/Jbc.271.1.361 |
0.447 |
|
| 1996 |
Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB. Erratum: Crystal structure of a G-protein βγ dimer at 2.1 Å resolution Nature. 379: 847-847. DOI: 10.1038/379847A0 |
0.336 |
|
| 1995 |
Slepak VZ, Artemyev NO, Zhu Y, Dumke CL, Sabacan L, Sondek J, Hamm HE, Bownds MD, Arshavsky VY. An effector site that stimulates G-protein GTPase in photoreceptors Journal of Biological Chemistry. 270: 14319-14324. PMID 7782290 DOI: 10.1074/Jbc.270.24.14319 |
0.696 |
|
| 1995 |
Skiba NP, Artemyev NO, Hamm HE. The carboxyl terminus of the γ-subunit of rod cGMP phosphodiesterase contains distinct sites of interaction with the enzyme catalytic subunits and the α-subunit of transducin Journal of Biological Chemistry. 270: 13210-13215. PMID 7768919 DOI: 10.1074/Jbc.270.22.13210 |
0.638 |
|
| 1995 |
Rens-Domiano S, Hamm HE. Structural and functional relationships of heterotrimeric G-proteins Faseb Journal. 9: 1059-1066. DOI: 10.1096/Fasebj.9.11.7649405 |
0.477 |
|
| 1994 |
Lambright DG, Noel JP, Hamm HE, Sigler PB. Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Nature. 369: 621-8. PMID 8208289 DOI: 10.1038/369621A0 |
0.417 |
|
| 1994 |
Arshavsky VY, Dumke CL, Zhu Y, Artemyev NO, Skiba NP, Hamm HE, Bownds MD. Regulation of transducin GTPase activity in bovine rod outer segments Journal of Biological Chemistry. 269: 19882-19887. PMID 8051070 |
0.652 |
|
| 1994 |
Sondek J, Lambright DG, Noel JP, Hamm HE, Sigler PB. GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. Nature. 372: 276-9. PMID 7969474 DOI: 10.1038/372276A0 |
0.38 |
|
| 1994 |
Hamm HE, Rarick HM. [32] Specific peptide probes for G-protein interactions with receptors Methods in Enzymology. 237: 423-436. PMID 7935015 DOI: 10.1016/S0076-6879(94)37079-6 |
0.444 |
|
| 1994 |
Rarick HM, Artemyev NO, Mills JS, Skiba NP, Hamm HE. Specific peptide probes for G-protein interaction with effectors Methods in Enzymology. 238: 13-28. PMID 7799779 DOI: 10.1016/0076-6879(94)38004-X |
0.591 |
|
| 1994 |
Artemyev NO, Hamm HE. Probing G-protein function Nature Structural Biology. 1: 752-754. PMID 7634081 DOI: 10.1038/Nsb1194-752 |
0.644 |
|
| 1993 |
Mazzoni MR, Hamm HE. Tryptophan207 is involved in the GTP-dependent conformational switch in the α subunit of the G protein transducin: Chymotryptic digestion patterns of the GTPγS and GDP-bound forms Journal of Protein Chemistry. 12: 215-221. PMID 8489707 DOI: 10.1007/Bf01026043 |
0.332 |
|
| 1993 |
Dratz EA, Furstenau JE, Lambert CG, Thireault DL, Rarick H, Schepers T, Pakhlevaniants S, Hamm HE. NMR structure of a receptor-bound G-protein peptide Nature. 363: 276-281. PMID 8487866 DOI: 10.1038/363276A0 |
0.511 |
|
| 1993 |
Hargrave PA, Hamm HE, Hofmann KP. Interaction of rhodopsin with the G-protein, transducin Bioessays. 15: 43-50. PMID 8466475 DOI: 10.1002/Bies.950150107 |
0.463 |
|
| 1993 |
Noel JP, Hamm HE, Sigler PB. The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. Nature. 366: 654-63. PMID 8259210 DOI: 10.1038/366654A0 |
0.411 |
|
| 1993 |
Artemyev NO, Mills JS, Thornburg KR, Knapp DR, Schey KL, Hamm HE. A site on transducin α-subunit of interaction with the polycationic region of cGMP phosphodiesterase inhibitory subunit Journal of Biological Chemistry. 268: 23611-23615. PMID 8226888 |
0.582 |
|
| 1993 |
Rasenick MM, Lazarevic M, Watanabe M, Hamm HE. Permeable Cell Systems as Models for Studying Disruption, by Site-Specific Synthetic Peptides, of Receptor-G Protein-Effector Coupling Methods. 5: 252-257. DOI: 10.1006/Meth.1993.1031 |
0.422 |
|
| 1993 |
Artemyev NO, Skiba NP, Mills JS, Hamm HE. Rod cGMP-Phosphodiesterase γ-Subunit: Structure-Function Relationships Methods. 5: 220-228. DOI: 10.1006/Meth.1993.1027 |
0.649 |
|
| 1992 |
Mangels LA, Neubig RR, Hamm HE, Gnegy ME. Calmodulin binding distinguishes between βγ subunits of activated G proteins and transducin Biochemical Journal. 283: 683-690. PMID 1590758 DOI: 10.1042/Bj2830683 |
0.389 |
|
| 1992 |
Artemyev NO, Rarick HM, Mills JS, Skiba NP, Hamm HE. Sites of interaction between rod G-protein α-subunit and cGMP-phosphodiesterase γ-subunit: Implications for the phosphodiesterase activation mechanism Journal of Biological Chemistry. 267: 25067-25072. PMID 1334079 |
0.578 |
|
| 1992 |
Rarick HM, Artemyev NO, Hamm HE. A site on rod G protein α subunit that mediates effector activation Science. 256: 1031-1033. PMID 1317058 DOI: 10.1126/Science.1317058 |
0.697 |
|
| 1992 |
Artemyev NO, Hamm HE. Two-site high-affinity interaction between inhibitory and catalytic subunits of rod cyclic GMP phosphodiesterase Biochemical Journal. 283: 273-279. PMID 1314566 DOI: 10.1042/Bj2830273 |
0.607 |
|
| 1992 |
Stieve H, Niemeyer B, Aktories K, Hamm HE. Disturbing gtp-binding protein function through microinjection into the visual cell of limulus Zeitschrift Fur Naturforschung - Section C Journal of Biosciences. 47: 915-921. PMID 1285831 DOI: 10.1515/Znc-1992-11-1220 |
0.435 |
|
| 1991 |
Warpeha KMF, Hamm HE, Rasenick MM, Kaufman LS. A blue-light-activated GTP-binding protein in the plasma membranes of etiolated peas Proceedings of the National Academy of Sciences of the United States of America. 88: 8925-8929. PMID 1924352 DOI: 10.1073/Pnas.88.20.8925 |
0.445 |
|
| 1991 |
Hamm HE. Molecular interactions between the photoreceptor G protein and rhodopsin Cellular and Molecular Neurobiology. 11: 563-578. PMID 1782650 DOI: 10.1007/Bf00741446 |
0.455 |
|
| 1990 |
Hamm HE, Rarick H, Mazzoni M, Malinski J, Suh KH. The molecular basis of GTP-binding protein interaction with receptors Biochemical Society Symposia. 56: 35-44. PMID 2256961 |
0.309 |
|
| 1990 |
Robinson PR, Wood SF, Szuts EZ, Fein A, Hamm HE, Lisman JE. Light-dependent GTP-binding proteins in squid photoreceptors. The Biochemical Journal. 272: 79-85. PMID 2124806 DOI: 10.1042/Bj2720079 |
0.614 |
|
| 1989 |
Hamm HE, Deretic D, Mazzoni MR, Moore CA, Takahashi JS, Rasenick MM. A monoclonal antibody against the rod outer segment guanyl nucleotide-binding protein, transducin, blocks the stimulatory and inhibitory G proteins of adenylate cyclase. The Journal of Biological Chemistry. 264: 11475-82. PMID 2544596 |
0.565 |
|
| 1989 |
Mazzoni MR, Hamm HE. Effect of monoclonal antibody binding on α-βγ subunit interactions in the rod outer segment G protein, Gt Biochemistry. 28: 9873-9880. PMID 2482080 DOI: 10.1021/Bi00451A047 |
0.338 |
|
| 1988 |
Brown AM, Yatani A, Imoto Y, Kirsch G, Hamm H, Codina J, Mattera R, Birnbaumer L. Direct coupling of G proteins to ionic channels. Cold Spring Harbor Symposia On Quantitative Biology. 53: 365-73. PMID 3151174 DOI: 10.1101/Sqb.1988.053.01.044 |
0.337 |
|
| 1988 |
Hamm HE, Deretic D, Arendt A, Hargrave PA, Koenig B, Hofmann KP. Site of G protein binding to rhodopsin mapped with synthetic peptides from the α subunit Science. 241: 832-835. PMID 3136547 DOI: 10.1126/Science.3136547 |
0.467 |
|
| 1988 |
Yatani A, Hamm H, Codina J, Mazzoni MR, Birnbaumer L, Brown AM. A monoclonal antibody to the alpha subunit of Gk blocks muscarinic activation of atrial K+ channels. Science (New York, N.Y.). 241: 828-31. PMID 2457252 DOI: 10.1126/Science.2457252 |
0.405 |
|
| 1987 |
Hamm HE, Deretic D, Hofmann KP, Schleicher A, Kohl B. Mechanism of action of monoclonal antibodies that block the light activation of the guanyl nucleotide-binding protein, transducin Journal of Biological Chemistry. 262: 10831-10838. PMID 2440875 |
0.307 |
|
| 1986 |
Hamm HE, Deric Bownds M. Protein complement of rod outer segments of frog retina Biochemistry®. 25: 4512-4523. PMID 3021191 DOI: 10.1021/Bi00364A010 |
0.365 |
|
| 1984 |
Witt PL, Hamm HE, Bownds MD. Preparation and characterization of monoclonal antibodies to several frog rod outer segment proteins Journal of General Physiology. 84: 251-263. PMID 6387041 DOI: 10.1085/Jgp.84.2.251 |
0.357 |
|
| 1984 |
Hamm HE, Bownds MD. A monoclonal antibody to guanine necleotide binding protein inhibits the light-activated cyclic GMP pathway in frog rod outer segments Journal of General Physiology. 84: 265-280. PMID 6092516 DOI: 10.1085/Jgp.84.2.265 |
0.394 |
|
| 1983 |
Hamm HE, Takahashi JS, Menaker M. Light-induced decrease of serotonin N-acetyltransferase activity and melatonin in the chicken pineal gland and retina. Brain Research. 266: 287-93. PMID 6871664 DOI: 10.1016/0006-8993(83)90660-1 |
0.634 |
|
| 1982 |
Hermolin J, Karell MA, Hamm HE, Bownds MD. Calcium and cyclic GMP regulation of light-sensitive protein phosphorylation in frog photoreceptor membranes Journal of General Physiology. 79: 633-655. PMID 6279759 DOI: 10.1085/Jgp.79.4.633 |
0.345 |
|
| 1981 |
Hamm HE, Menaker M. Pineal and retinal serotonin N-acetyltransferase activity: modulation by phosphate. Journal of Neurochemistry. 37: 1567-72. PMID 7334376 DOI: 10.1111/J.1471-4159.1981.Tb06328.X |
0.558 |
|
| 1980 |
Hamm HE, Menaker M. Retinal rhythms in chicks: circadian variation in melantonin and serotonin N-acetyltransferase activity. Proceedings of the National Academy of Sciences of the United States of America. 77: 4998-5002. PMID 6933543 DOI: 10.1073/Pnas.77.8.4998 |
0.529 |
|
| 1980 |
Takahashi JS, Hamm H, Menaker M. Circadian rhythms of melatonin release from individual superfused chicken pineal glands in vitro. Proceedings of the National Academy of Sciences of the United States of America. 77: 2319-22. PMID 6929552 DOI: 10.1073/Pnas.77.4.2319 |
0.608 |
|
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