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Stephen G. Brohawn, PhD - Publications

Affiliations: 
Rockefeller University, New York, NY, United States 
 Molecular and Cell Biology University of California, Berkeley, Berkeley, CA, United States 
Area:
Molecular basis of sensory transduction and cellular electrical signaling
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27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG. Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nature Structural & Molecular Biology. PMID 36928458 DOI: 10.1038/s41594-023-00944-6  0.457
2023 Sorum B, Docter T, Panico V, Rietmeijer RA, Brohawn SG. Pressure and ultrasound activate mechanosensitive TRAAK K channels through increased membrane tension. Biorxiv : the Preprint Server For Biology. PMID 36712118 DOI: 10.1101/2023.01.11.523644  0.398
2022 Hoel CM, Zhang L, Brohawn SG. Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A. Elife. 11. PMID 36373655 DOI: 10.7554/eLife.81704  0.386
2022 Tucker K, Sridharan S, Adesnik H, Brohawn SG. Cryo-EM structures of the channelrhodopsin ChRmine in lipid nanodiscs. Nature Communications. 13: 4842. PMID 35977941 DOI: 10.1038/s41467-022-32441-7  0.365
2022 Turney TS, Li V, Brohawn SG. Structural Basis for pH-gating of the K channel TWIK1 at the selectivity filter. Nature Communications. 13: 3232. PMID 35680900 DOI: 10.1038/s41467-022-30853-z  0.324
2021 Li B, Hoel CM, Brohawn SG. Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca-dependent switch from intra- to intermembrane dimerization. Nature Communications. 12: 6913. PMID 34824283 DOI: 10.1038/s41467-021-27283-8  0.354
2021 Rietmeijer RA, Sorum B, Li B, Brohawn SG. Physical basis for distinct basal and mechanically gated activity of the human K channel TRAAK. Neuron. PMID 34390650 DOI: 10.1016/j.neuron.2021.07.009  0.415
2021 Sorum B, Rietmeijer RA, Gopakumar K, Adesnik H, Brohawn SG. Ultrasound activates mechanosensitive TRAAK K channels through the lipid membrane. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33542098 DOI: 10.1073/pnas.2006980118  0.404
2020 Li B, Rietmeijer RA, Brohawn SG. Structural basis for pH gating of the two-pore domain K channel TASK2. Nature. 586: 457-462. PMID 32999458 DOI: 10.1038/s41586-020-2770-2  0.363
2020 Reid MS, Kern DM, Brohawn SG. Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs. Elife. 9. PMID 32286222 DOI: 10.7554/Elife.52505  0.417
2019 Brohawn SG, Wang W, Handler A, Campbell EB, Schwarz JR, MacKinnon R. The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier. Elife. 8. PMID 31674909 DOI: 10.7554/Elife.50403  0.525
2019 Kern DM, Oh S, Hite RK, Brohawn SG. Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs. Elife. 8. PMID 30775971 DOI: 10.7554/Elife.42636  0.711
2019 Reid MS, Kern DM, Brohawn SG. Author response: Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs Elife. DOI: 10.7554/Elife.52505.Sa2  0.38
2019 Brohawn SG, Wang W, Handler A, Campbell EB, Schwarz JR, MacKinnon R. Author response: The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier Elife. DOI: 10.7554/Elife.50403.022  0.552
2019 Kern DM, Oh S, Hite RK, Brohawn SG. Author response: Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs Elife. DOI: 10.7554/Elife.42636.048  0.677
2018 Del Mármol J, Rietmeijer RA, Brohawn SG. Studying Mechanosensitivity of Two-Pore Domain K(+) Channels in Cellular and Reconstituted Proteoliposome Membranes. Methods in Molecular Biology (Clifton, N.J.). 1684: 129-150. PMID 29058189 DOI: 10.1007/978-1-4939-7362-0_11  0.507
2015 Brohawn SG. How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2. Annals of the New York Academy of Sciences. 1352: 20-32. PMID 26332952 DOI: 10.1111/Nyas.12874  0.488
2014 Brohawn SG, Campbell EB, MacKinnon R. Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature. 516: 126-30. PMID 25471887 DOI: 10.1038/Nature14013  0.64
2014 Brohawn SG, Su Z, MacKinnon R. Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 111: 3614-9. PMID 24550493 DOI: 10.1073/Pnas.1320768111  0.623
2013 Brohawn SG, Campbell EB, MacKinnon R. Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 110: 2129-34. PMID 23341632 DOI: 10.1073/Pnas.1218950110  0.647
2012 Brohawn SG, del Mármol J, MacKinnon R. Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. Science (New York, N.Y.). 335: 436-41. PMID 22282805 DOI: 10.1126/Science.1213808  0.646
2009 Brohawn SG, Schwartz TU. Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice. Nature Structural & Molecular Biology. 16: 1173-7. PMID 19855394 DOI: 10.1038/Nsmb.1713  0.58
2009 Brohawn SG, Partridge JR, Whittle JR, Schwartz TU. The nuclear pore complex has entered the atomic age. Structure (London, England : 1993). 17: 1156-68. PMID 19748337 DOI: 10.1016/J.Str.2009.07.014  0.578
2009 Brohawn SG, Schwartz TU. A lattice model of the nuclear pore complex. Communicative & Integrative Biology. 2: 205-7. PMID 19641729 DOI: 10.4161/Cib.2.3.7873  0.593
2009 Leksa NC, Brohawn SG, Schwartz TU. The structure of the scaffold nucleoporin Nup120 reveals a new and unexpected domain architecture. Structure (London, England : 1993). 17: 1082-91. PMID 19576787 DOI: 10.1016/J.Str.2009.06.003  0.575
2008 Brohawn SG, Leksa NC, Spear ED, Rajashankar KR, Schwartz TU. Structural evidence for common ancestry of the nuclear pore complex and vesicle coats. Science (New York, N.Y.). 322: 1369-73. PMID 18974315 DOI: 10.1126/Science.1165886  0.626
2006 Schwartz TU, Schmidt D, Brohawn SG, Blobel G. Homodimerization of the G protein SRbeta in the nucleotide-free state involves proline cis/trans isomerization in the switch II region. Proceedings of the National Academy of Sciences of the United States of America. 103: 6823-8. PMID 16627619 DOI: 10.1073/Pnas.0602083103  0.625
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