Lisa M Ellerby - Publications

Buck Institute for Research on Aging 

95 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Scott GK, Mahoney S, Scott M, Loureiro A, Lopez-Ramirez A, Tanner JJ, Ellerby LM, Benz CC. Correction to: N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties. Amino Acids. PMID 34286353 DOI: 10.1007/s00726-021-03045-0  1
2021 Scott GK, Mahoney S, Scott M, Loureiro A, Lopez-Ramirez A, Tanner JJ, Ellerby LM, Benz CC. N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties. Amino Acids. PMID 34089390 DOI: 10.1007/s00726-021-03012-9  1
2021 Ehrlich ME, Ellerby LM. Neuronal intranuclear inclusion disease: Polyglycine protein is the culprit. Neuron. 109: 1757-1760. PMID 34081916 DOI: 10.1016/j.neuron.2021.05.018  1
2021 Bailus BJ, Scheeler SM, Simons J, Sanchez MA, Tshilenge KT, Creus-Muncunill J, Naphade S, Lopez-Ramirez A, Zhang N, Lakshika Madushani K, Moroz S, Loureiro A, Schreiber KH, Hausch F, Kennedy BK, ... ... Ellerby LM, et al. Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels. Autophagy. 1-22. PMID 34024231 DOI: 10.1080/15548627.2021.1904489  1
2021 Sorek M, Oweis W, Nissim-Rafinia M, Maman M, Simon S, Hession CC, Adiconis X, Simmons SK, Sanjana NE, Shi X, Lu C, Pan JQ, Xu X, Pouladi MA, Ellerby LM, et al. Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity. Genome Biology. 22: 73. PMID 33663567 DOI: 10.1186/s13059-021-02301-6  0.01
2020 Voisin J, Farina F, Naphade S, Fontaine M, Tshilenge KT, Galicia Aguirre C, Lopez-Ramirez A, Dancourt J, Ginisty A, Sasidharan Nair S, Lakshika Madushani K, Zhang N, Lejeune FX, Verny M, Campisi J, ... Ellerby LM, et al. FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16 increase. Aging Cell. e13226. PMID 33156570 DOI: 10.1111/acel.13226  1
2020 García-Huerta P, Troncoso-Escudero P, Wu D, Thiruvalluvan A, Cisternas-Olmedo M, Henríquez DR, Plate L, Chana-Cuevas P, Saquel C, Thielen P, Longo KA, Geddes BJ, Lederkremer GZ, Sharma N, Shenkman M, ... ... Ellerby LM, et al. Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates. Acta Neuropathologica. PMID 32642868 DOI: 10.1007/S00401-020-02183-1  1
2020 Ellerby LM. Repeat Expansion Disorders: Mechanisms and Therapeutics. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 31907874 DOI: 10.1007/S13311-019-00823-3  0.01
2019 Naphade S, Tshilenge KT, Ellerby LM. Modeling Polyglutamine Expansion Diseases with Induced Pluripotent Stem Cells. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 16: 979-998. PMID 31792895 DOI: 10.1007/S13311-019-00810-8  1
2019 Cirnaru MD, Melis C, Fanutza T, Naphade S, Tshilenge KN, Muntean BS, Martemyanov KA, Plotkin JL, Ellerby LM, Ehrlich ME. Nuclear receptor Nr4a1 regulates striatal striosome development and dopamine D1 receptor signaling. Eneuro. PMID 31541002 DOI: 10.1523/ENEURO.0305-19.2019  1
2019 Taki M, Rohilla KJ, Barton M, Funneman M, Benzabeh N, Naphade S, Ellerby LM, Gagnon KT, Shamsi MH. Novel probes for label-free detection of neurodegenerative GGGGCC repeats associated with amyotrophic lateral sclerosis. Analytical and Bioanalytical Chemistry. PMID 31435686 DOI: 10.1007/S00216-019-02075-8  1
2019 Gao R, Chakraborty A, Geater C, Pradhan S, Gordon KL, Snowden J, Yuan S, Dickey AS, Choudhary S, Ashizawa T, Ellerby LM, La Spada AR, Thompson LM, Hazra TK, Sarkar PS. Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription. Elife. 8. PMID 30994454 DOI: 10.7554/Elife.42988  1
2019 Ellerby LM. Decision letter: Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls Elife. DOI: 10.7554/Elife.50333.Sa1  0.01
2019 Gao R, Chakraborty A, Geater C, Pradhan S, Gordon KL, Snowden J, Yuan S, Dickey AS, Choudhary S, Ashizawa T, Ellerby LM, Spada ARL, Thompson LM, Hazra TK, Sarkar PS. Author response: Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription Elife. DOI: 10.7554/Elife.42988.033  1
2019 Ellerby L, Song S, Mooney S, Scheeler S, Naphade S. Genomic Analysis Of Human Isogenic Apoe Ipsc-Derived Inhibitory Gabaergic Neurons Innovation in Aging. 3. DOI: 10.1093/Geroni/Igz038.2315  1
2017 Naphade S, Embusch A, Madushani KL, Ring KL, Ellerby LM. Altered Expression of Matrix Metalloproteinases and Their Endogenous Inhibitors in a Human Isogenic Stem Cell Model of Huntington's Disease. Frontiers in Neuroscience. 11: 736. PMID 29459817 DOI: 10.3389/Fnins.2017.00736  1
2017 Quinti L, Dayalan Naidu S, Träger U, Chen X, Kegel-Gleason K, Llères D, Connolly C, Chopra V, Low C, Moniot S, Sapp E, Tousley AR, Vodicka P, Van Kanegan MJ, Kaltenbach LS, ... ... Ellerby LM, et al. KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients. Proceedings of the National Academy of Sciences of the United States of America. PMID 28533375 DOI: 10.1073/Pnas.1614943114  1
2016 Tracy TE, Sohn PD, Minami SS, Wang C, Min SW, Li Y, Zhou Y, Le D, Lo I, Ponnusamy R, Cong X, Schilling B, Ellerby LM, Huganir RL, Gan L. Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. PMID 27041503 DOI: 10.1016/J.Neuron.2016.03.005  1
2016 Voisin J, Farina F, Lejeune F, Ellerby LM, Neri C. B19 RNAseq and chipseq analysis of FOXO3 targets in an huntington’s disease human neural stem cell model Journal of Neurology, Neurosurgery, and Psychiatry. 87. DOI: 10.1136/Jnnp-2016-314597.50  1
2015 Ring KL, An MC, Zhang N, O'Brien RN, Ramos EM, Gao F, Atwood R, Bailus BJ, Melov S, Mooney SD, Coppola G, Ellerby LM. Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells. Stem Cell Reports. 5: 1023-1038. PMID 26651603 DOI: 10.1016/J.Stemcr.2015.11.005  1
2015 Zhang N, Bailus BJ, Ring KL, Ellerby LM. iPSC-based drug screening for Huntington׳s disease. Brain Research. PMID 26428226 DOI: 10.1016/J.Brainres.2015.09.020  1
2015 Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, et al. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nature Medicine. PMID 26390242 DOI: 10.1038/Nm.3951  1
2015 O'Brien R, DeGiacomo F, Holcomb J, Bonner A, Ring KL, Zhang N, Zafar K, Weiss A, Lager B, Schilling B, Gibson BW, Chen S, Kwak S, Ellerby LM. Integration Independent Transgenic Huntington's Disease Fragment Mouse Models Reveal Distinct Phenotypes and Lifespan In Vivo. The Journal of Biological Chemistry. PMID 26025364 DOI: 10.1074/Jbc.M114.623561  1
2015 Guyenet SJ, Mookerjee SS, Lin A, Custer SK, Chen SF, Sopher BL, La Spada AR, Ellerby LM. Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction. Human Molecular Genetics. 24: 3908-17. PMID 25859008 DOI: 10.1093/Hmg/Ddv121  1
2014 An MC, O'Brien RN, Zhang N, Patra BN, De La Cruz M, Ray A, Ellerby LM. Polyglutamine Disease Modeling: Epitope Based Screen for Homologous Recombination using CRISPR/Cas9 System. Plos Currents. 6. PMID 24761311 DOI: 10.1371/Currents.Hd.0242D2E7Ad72225Efa72F6964589369A  1
2013 Duncan CE, An MC, Papanikolaou T, Rugani C, Vitelli C, Ellerby LM. Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model. Molecular Neurodegeneration. 8: 42. PMID 24160175 DOI: 10.1186/1750-1326-8-42  1
2012 Sarantos MR, Papanikolaou T, Ellerby LM, Hughes RE. Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease. Journal of Huntington's Disease. 1: 195-210. PMID 23393546 DOI: 10.3233/Jhd-120033  1
2012 Miller JP, Yates BE, Al-Ramahi I, Berman AE, Sanhueza M, Kim E, de Haro M, DeGiacomo F, Torcassi C, Holcomb J, Gafni J, Mooney SD, Botas J, Ellerby LM, Hughes RE. A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease. Plos Genetics. 8: e1003042. PMID 23209424 DOI: 10.1371/Journal.Pgen.1003042  1
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Ellerby LM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.01
2012 Zou Y, Zhang N, Ellerby LM, Davalos AR, Zeng X, Campisi J, Desprez PY. Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation. Biochemical and Biophysical Research Communications. 426: 100-5. PMID 22917535 DOI: 10.1016/J.Bbrc.2012.08.043  1
2012 An MC, Zhang N, Scott G, Montoro D, Wittkop T, Mooney S, Melov S, Ellerby LM. Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells. Cell Stem Cell. 11: 253-63. PMID 22748967 DOI: 10.1016/J.Stem.2012.04.026  1
2012 Gafni J, Papanikolaou T, Degiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen PI, Lehtimäki KK, Yang XW, Park L, Kwak S, ... ... Ellerby LM, et al. Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7454-65. PMID 22649225 DOI: 10.1523/Jneurosci.6379-11.2012  1
2012 Zhang N, Li B, Al-Ramahi I, Cong X, Held JM, Kim E, Botas J, Gibson BW, Ellerby LM. Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity. The Journal of Biological Chemistry. 287: 21204-13. PMID 22511757 DOI: 10.1074/Jbc.M111.321661  1
2011 Cong X, Held JM, DeGiacomo F, Bonner A, Chen JM, Schilling B, Czerwieniec GA, Gibson BW, Ellerby LM. Mass spectrometric identification of novel lysine acetylation sites in huntingtin. Molecular & Cellular Proteomics : McP. 10: M111.009829. PMID 21685499 DOI: 10.1074/Mcp.M111.009829  1
2010 Leyva MJ, Degiacomo F, Kaltenbach LS, Holcomb J, Zhang N, Gafni J, Park H, Lo DC, Salvesen GS, Ellerby LM, Ellman JA. Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models. Chemistry & Biology. 17: 1189-200. PMID 21095569 DOI: 10.1016/J.Chembiol.2010.08.014  1
2010 Zhang N, An MC, Montoro D, Ellerby LM. Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells. Plos Currents. 2: RRN1193. PMID 21037797 DOI: 10.1371/Currents.Rrn1193  1
2010 Miller JP, Holcomb J, Al-Ramahi I, de Haro M, Gafni J, Zhang N, Kim E, Sanhueza M, Torcassi C, Kwak S, Botas J, Hughes RE, Ellerby LM. Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Neuron. 67: 199-212. PMID 20670829 DOI: 10.1016/J.Neuron.2010.06.021  1
2010 Duncan C, Papanikolaou T, Ellerby LM. Autophagy: polyQ toxic fragment turnover. Autophagy. 6: 312-4. PMID 20104018 DOI: 10.4161/Auto.6.2.11139  1
2010 Landles C, Sathasivam K, Weiss A, Woodman B, Moffitt H, Finkbeiner S, Sun B, Gafni J, Ellerby LM, Trottier Y, Richards WG, Osmand A, Paganetti P, Bates GP. Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease. The Journal of Biological Chemistry. 285: 8808-23. PMID 20086007 DOI: 10.1074/Jbc.M109.075028  1
2009 Mookerjee S, Papanikolaou T, Guyenet SJ, Sampath V, Lin A, Vitelli C, DeGiacomo F, Sopher BL, Chen SF, La Spada AR, Ellerby LM. Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15134-44. PMID 19955365 DOI: 10.1523/Jneurosci.4720-09.2009  1
2009 Papanikolaou T, Ellerby LM. IGF-1: elixir for motor neuron diseases. Neuron. 63: 277-8. PMID 19679066 DOI: 10.1016/J.Neuron.2009.07.024  1
2009 Gafni J, Cong X, Chen SF, Gibson BW, Ellerby LM. Calpain-1 cleaves and activates caspase-7. The Journal of Biological Chemistry. 284: 25441-9. PMID 19617626 DOI: 10.1074/Jbc.M109.038174  1
2009 Young JE, Garden GA, Martinez RA, Tanaka F, Sandoval CM, Smith AC, Sopher BL, Lin A, Fischbeck KH, Ellerby LM, Morrison RS, Taylor JP, La Spada AR. Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1987-97. PMID 19228953 DOI: 10.1523/Jneurosci.4072-08.2009  1
2007 Young JE, Gouw L, Propp S, Sopher BL, Taylor J, Lin A, Hermel E, Logvinova A, Chen SF, Chen S, Bredesen DE, Truant R, Ptacek LJ, La Spada AR, Ellerby LM. Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation. The Journal of Biological Chemistry. 282: 30150-60. PMID 17646170 DOI: 10.1074/Jbc.M705265200  1
2007 Khan AA, Sun Y, Jin K, Mao XO, Chen S, Ellerby LM, Greenberg DA. A neuroglobin-overexpressing transgenic mouse. Gene. 398: 172-6. PMID 17537594 DOI: 10.1016/J.Gene.2007.02.044  1
2007 Kaltenbach LS, Romero E, Becklin RR, Chettier R, Bell R, Phansalkar A, Strand A, Torcassi C, Savage J, Hurlburt A, Cha GH, Ukani L, Chepanoske CL, Zhen Y, Sahasrabudhe S, ... ... Ellerby LM, et al. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. Plos Genetics. 3: e82. PMID 17500595 DOI: 10.1371/Journal.Pgen.0030082  1
2007 Oliveira JM, Jekabsons MB, Chen S, Lin A, Rego AC, Gonçalves J, Ellerby LM, Nicholls DG. Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice. Journal of Neurochemistry. 101: 241-9. PMID 17394466 DOI: 10.1111/J.1471-4159.2006.04361.X  1
2006 Khan AA, Wang Y, Sun Y, Mao XO, Xie L, Miles E, Graboski J, Chen S, Ellerby LM, Jin K, Greenberg DA. Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Proceedings of the National Academy of Sciences of the United States of America. 103: 17944-8. PMID 17098866 DOI: 10.1073/Pnas.0607497103  1
2006 Oliveira JM, Chen S, Almeida S, Riley R, Gonçalves J, Oliveira CR, Hayden MR, Nicholls DG, Ellerby LM, Rego AC. Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11174-86. PMID 17065457 DOI: 10.1523/Jneurosci.3004-06.2006  1
2006 Ellerby LM, Orr HT. Neurodegenerative disease: cut to the chase. Nature. 442: 641-2. PMID 16900190 DOI: 10.1038/442641A  1
2006 Sandoval CM, Geierstanger BH, Fujimura S, Balatbat C, Williams T, de Unamuno J, Whiles-Lillig JA, Ellerby LM, Ellerby HM, Jennings P, Plesniak LA. Structural evaluation of a novel pro-apoptotic peptide coupled to CNGRC tumor homing sequence by NMR. Chemical Biology & Drug Design. 67: 417-24. PMID 16882316 DOI: 10.1111/J.1747-0285.2006.00394.X  1
2006 Schilling B, Gafni J, Torcassi C, Cong X, Row RH, LaFevre-Bernt MA, Cusack MP, Ratovitski T, Hirschhorn R, Ross CA, Gibson BW, Ellerby LM. Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity. The Journal of Biological Chemistry. 281: 23686-97. PMID 16782707 DOI: 10.1074/Jbc.M513507200  1
2006 Taylor J, Grote SK, Xia J, Vandelft M, Graczyk J, Ellerby LM, La Spada AR, Truant R. Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal. The Journal of Biological Chemistry. 281: 2730-9. PMID 16314424 DOI: 10.1074/Jbc.M506751200  1
2006 Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, Crippen D, Wood JD, Sawa A, Jenkins NA, Copeland NG, Borchelt DR, Ross CA, Ellerby LM. Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin. Neurobiology of Disease. 21: 381-91. PMID 16150600 DOI: 10.1016/J.Nbd.2005.07.014  1
2006 Garden GA, Truant R, Ellerby LM, La Spada AR. Spinocerebellar ataxia type 7: Clinical features to cellular pathogenesis Genetic Instabilities and Neurological Diseases, Second Edition. 399-416. DOI: 10.1016/B978-012369462-1/50028-4  1
2005 Jin K, LaFevre-Bernt M, Sun Y, Chen S, Gafni J, Crippen D, Logvinova A, Ross CA, Greenberg DA, Ellerby LM. FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease. Proceedings of the National Academy of Sciences of the United States of America. 102: 18189-94. PMID 16326808 DOI: 10.1073/Pnas.0506375102  1
2005 Iwata A, Christianson JC, Bucci M, Ellerby LM, Nukina N, Forno LS, Kopito RR. Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation. Proceedings of the National Academy of Sciences of the United States of America. 102: 13135-40. PMID 16141322 DOI: 10.1073/Pnas.0505801102  1
2004 Berke SJ, Schmied FA, Brunt ER, Ellerby LM, Paulson HL. Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3. Journal of Neurochemistry. 89: 908-18. PMID 15140190 DOI: 10.1111/J.1471-4159.2004.02369.X  1
2004 Sopher BL, Thomas PS, LaFevre-Bernt MA, Holm IE, Wilke SA, Ware CB, Jin LW, Libby RT, Ellerby LM, La Spada AR. Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration. Neuron. 41: 687-99. PMID 15003169 DOI: 10.1016/S0896-6273(04)00082-0  1
2004 Gafni J, Hermel E, Young JE, Wellington CL, Hayden MR, Ellerby LM. Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus. The Journal of Biological Chemistry. 279: 20211-20. PMID 14981075 DOI: 10.1074/Jbc.M401267200  1
2004 Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, ... ... Ellerby LM, et al. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death and Differentiation. 11: 424-38. PMID 14713958 DOI: 10.1038/Sj.Cdd.4401358  1
2003 LaFevre-Bernt MA, Ellerby LM. Kennedy's disease. Phosphorylation of the polyglutamine-expanded form of androgen receptor regulates its cleavage by caspase-3 and enhances cell death. The Journal of Biological Chemistry. 278: 34918-24. PMID 12824190 DOI: 10.1074/Jbc.M302841200  1
2003 Ellerby HM, Lee S, Ellerby LM, Chen S, Kiyota T, Del Rio G, Sugihara G, Sun Y, Bredesen DE, Arap W, Pasqualini R. An artificially designed pore-forming protein with anti-tumor effects Journal of Biological Chemistry. 278: 35311-35316. PMID 12750379 DOI: 10.1074/Jbc.M300474200  1
2003 Kaur D, Yantiri F, Rajagopalan S, Kumar J, Mo JQ, Boonplueang R, Viswanath V, Jacobs R, Yang L, Beal MF, DiMonte D, Volitaskis I, Ellerby L, Cherny RA, Bush AI, et al. Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. Neuron. 37: 899-909. PMID 12670420 DOI: 10.1016/S0896-6273(03)00126-0  1
2003 Nucifora FC, Ellerby LM, Wellington CL, Wood JD, Herring WJ, Sawa A, Hayden MR, Dawson VL, Dawson TM, Ross CA. Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity. The Journal of Biological Chemistry. 278: 13047-55. PMID 12464607 DOI: 10.1074/Jbc.M211224200  1
2003 Wellington CL, Ellerby LM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Huntington proteolysis in Huntington disease Clinical Neuroscience Research. 3: 129-139. DOI: 10.1016/S1566-2772(03)00055-0  1
2002 Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, et al. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7862-72. PMID 12223539 DOI: 10.1523/Jneurosci.22-18-07862.2002  1
2002 Gafni J, Ellerby LM. Calpain activation in Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4842-9. PMID 12077181 DOI: 10.1523/Jneurosci.22-12-04842.2002  1
2002 Rao RV, Peel A, Logvinova A, del Rio G, Hermel E, Yokota T, Goldsmith PC, Ellerby LM, Ellerby HM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. Febs Letters. 514: 122-8. PMID 11943137 DOI: 10.1016/S0014-5793(02)02289-5  1
2002 Ellerby LM. Hunting for excitement: NMDA receptors in Huntington's disease. Neuron. 33: 841-2. PMID 11906690 DOI: 10.1016/S0896-6273(02)00631-1  0.01
2001 Lee M, Hyun DH, Marshall KA, Ellerby LM, Bredesen DE, Jenner P, Halliwell B. Effect of overexpression of BCL-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome. Free Radical Biology & Medicine. 31: 1550-9. PMID 11744329 DOI: 10.1016/S0891-5849(01)00633-5  1
2001 Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, Brömme D, Krajewski S, Reed JC, Yin XM, Turk V, et al. Lysosomal protease pathways to apoptosis: Cleavage of Bid, not pro-caspases, is the most likely route Journal of Biological Chemistry. 276: 3149-3157. PMID 11073962 DOI: 10.1074/Jbc.M008944200  1
2000 Rabizadeh S, Ye X, Sperandio S, Wang JJL, Ellerby HM, Ellerby LM, Giza C, Andrusiak RL, Frankowski H, Yaron Y, Moayeri NN, Rovelli G, Evans CJ, Butcher LL, Nolan GP, et al. Neurotrophin dependence domain: A domain required for the mediation of apoptosis by the p75 neurotrophin receptor Journal of Molecular Neuroscience. 15: 215-229. PMID 11303785 DOI: 10.1385/Jmn:15:3:215  1
2000 Cafe C, Testa MP, Sheldon PJ, French WP, Ellerby LM, Bredesen DE. Loss of oxidation-reduction specificity in amyotrophic lateral sclerosis-associated CuZnSOD mutants. Journal of Molecular Neuroscience. 15: 71-83. PMID 11220787 DOI: 10.1385/Jmn:15:2:71  1
2000 Ellerby LM, Bredesen DE. Measurement of cellular oxidation, reactive oxygen species, and antioxidant enzymes during apoptosis. Methods in Enzymology. 322: 413-421. PMID 10914037 DOI: 10.1016/S0076-6879(00)22040-5  1
2000 Kluck RM, Ellerby LM, Ellerby HM, Naiem S, Yaffe MP, Margoliash E, Bredesen D, Mauk AG, Sherman F, Newmeyer DD. Determinants of cytochrome c pro-apoptotic activity: The role of lysine 72 trimethylation Journal of Biological Chemistry. 275: 16127-16133. PMID 10821864 DOI: 10.1074/Jbc.275.21.16127  1
2000 Wellington CL, Singaraja R, Ellerby L, Savill J, Roy S, Leavitt B, Cattaneo E, Hackam A, Sharp A, Thornberry N, Nicholson DW, Bredesen DE, Hayden MR. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells. The Journal of Biological Chemistry. 275: 19831-8. PMID 10770929 DOI: 10.1074/Jbc.M001475200  1
2000 Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nature Medicine. 6: 397-404. PMID 10742146 DOI: 10.1038/74656  1
2000 Lu DC, Shahrooz R, Shayya RF, Ellerby LM, Salvesen GS, Koo EH, Bredesen DE. A second cytotoxic proteolytic peptide derived from β-amyloid precursor protein Neurobiology of Aging. 21: 255. DOI: 10.1016/S0197-4580(00)83099-7  1
1999 Ellerby HM, Arap W, Ellerby LM, Kain R, Andrusiak R, Rio GD, Krajewski S, Lombardo CR, Rao R, Ruoslahti E, Bredesen DE, Pasqualini R. Anti-cancer activity of targeted pro-apoptotic peptides Nature Medicine. 5: 1032-1038. PMID 10470080 DOI: 10.1038/12469  1
1999 Krajewski S, Krajewska M, Ellerby LM, Welsh K, Xie Z, Deveraux QL, Salvesen GS, Bredesen DE, Rosenthal RE, Fiskum G, Reed JC. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia Proceedings of the National Academy of Sciences of the United States of America. 96: 5752-5757. PMID 10318956 DOI: 10.1073/Pnas.96.10.5752  1
1999 Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE. Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity. The Journal of Biological Chemistry. 274: 8730-6. PMID 10085113 DOI: 10.1074/Jbc.274.13.8730  1
1999 Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE. Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. Journal of Neurochemistry. 72: 185-95. PMID 9886069 DOI: 10.1046/J.1471-4159.1999.0720185.X  1
1998 Stennicke HR, Jürgensmeier JM, Shin H, Deveraux Q, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GS. Pro-caspase-3 is a major physiologic target of caspase-8. The Journal of Biological Chemistry. 273: 27084-90. PMID 9765224 DOI: 10.1074/Jbc.273.42.27084  1
1998 Jürgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC. Bax directly induces release of cytochrome c from isolated mitochondria Proceedings of the National Academy of Sciences of the United States of America. 95: 4997-5002. PMID 9560217 DOI: 10.1073/Pnas.95.9.4997  1
1998 Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, et al. Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. The Journal of Biological Chemistry. 273: 9158-67. PMID 9535906 DOI: 10.1074/Jbc.273.15.9158  1
1998 Martindale D, Hackam A, Wieczorek A, Ellerby L, Wellington C, McCutcheon K, Singaraja R, Kazemi-Esfarjani P, Devon R, Kim SU, Bredesen DE, Tufaro F, Hayden MR. Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates Nature Genetics. 18: 150-154. PMID 9462744 DOI: 10.1038/Ng0298-150  1
1997 Bredesen DE, Ellerby LM, Hart PJ, Wiedau-Pazos M, Valentine JS. Do posttranslational modifications of CuZnSOD lead to sporadic amyotrophic lateral sclerosis? Annals of Neurology. 42: 135-7. PMID 9266721 DOI: 10.1002/ana.410420202  1
1997 Longo VD, Ellerby LM, Bredesen DE, Valentine JS, Gralla EB. Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. The Journal of Cell Biology. 137: 1581-8. PMID 9199172 DOI: 10.1083/Jcb.137.7.1581  1
1996 Lyons TJ, Liu H, Goto JJ, Nersissian A, Roe JA, Graden JA, Café C, Ellerby LM, Bredesen DE, Gralla EB, Valentine JS. Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein. Proceedings of the National Academy of Sciences of the United States of America. 93: 12240-4. PMID 8901564 DOI: 10.1073/Pnas.93.22.12240  1
1996 Bredesen DE, Wiedau-Pazos M, Goto JJ, Rabizadeh S, Roe JA, Gralla EB, Ellerby LM, Valentine JS. Cell death mechanisms in ALS. Neurology. 47: S36-8; discussion S3. PMID 8858049 DOI: 10.1212/Wnl.47.4_Suppl_2.36S  1
1996 Ellerby LM, Ellerby HM, Park SM, Holleran AL, Murphy AN, Fiskum G, Kane DJ, Testa MP, Kayalar C, Bredesen DE. Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2. Journal of Neurochemistry. 67: 1259-67. PMID 8752134 DOI: 10.1046/J.1471-4159.1996.67031259.X  1
1996 Schultz JR, Ellerby LM, Gralla EB, Valentine JS, Clarke CF. Autoxidation of ubiquinol-6 is independent of superoxide dismutase. Biochemistry. 35: 6595-603. PMID 8639607 DOI: 10.1021/Bi960245H  1
1993 Tamai KT, Gralla EB, Ellerby LM, Valentine JS, Thiele DJ. Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase. Proceedings of the National Academy of Sciences of the United States of America. 90: 8013-7. PMID 8367458 DOI: 10.1073/Pnas.90.17.8013  1
1992 Ellerby LM, Nishida CR, Nishida F, Yamanaka SA, Dunn B, Valentine JS, Zink JI. Encapsulation of proteins in transparent porous silicate glasses prepared by the sol-gel method. Science (New York, N.Y.). 255: 1113-5. PMID 1312257 DOI: 10.1126/Science.1312257  1
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