Jonathan Chaires - Publications

Affiliations: 
University of Louisville, Louisville, KY, United States 
Area:
Biophysical Chemistry
Website:
https://louisville.edu/bucksforbrains/faculty/chaires

89 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Monsen RC, Chua EYD, Hopkins JB, Chaires JB, Trent JO. Structure of a 28.5 kDa duplex-embedded G-quadruplex system resolved to 7.4 Å resolution with cryo-EM. Nucleic Acids Research. PMID 36715343 DOI: 10.1093/nar/gkad014  0.797
2022 Monsen RC, Trent JO, Chaires JB. G-quadruplex DNA: A Longer Story. Accounts of Chemical Research. PMID 36282946 DOI: 10.1021/acs.accounts.2c00519  0.8
2022 Monsen RC, Maguire JM, DeLeeuw LW, Chaires JB, Trent JO. Drug discovery of small molecules targeting the higher-order hTERT promoter G-quadruplex. Plos One. 17: e0270165. PMID 35709230 DOI: 10.1371/journal.pone.0270165  0.789
2022 Monsen RC, DeLeeuw LW, Dean WL, Gray RD, Chakravarthy S, Hopkins JB, Chaires JB, Trent JO. Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Research. 50: 4127-4147. PMID 35325198 DOI: 10.1093/nar/gkac182  0.777
2021 DeLeeuw LW, Monsen RC, Petrauskas V, Gray RD, Baranauskiene L, Matulis D, Trent JO, Chaires JB. POT1 stability and binding measured by fluorescence thermal shift assays. Plos One. 16: e0245675. PMID 33784306 DOI: 10.1371/journal.pone.0245675  0.777
2021 Monsen RC, Chakravarthy S, Dean WL, Chaires JB, Trent JO. The solution structures of higher-order human telomere G-quadruplex multimers. Nucleic Acids Research. PMID 33469644 DOI: 10.1093/nar/gkaa1285  0.793
2020 Chaires JB, Gray RD, Dean WL, Monsen R, DeLeeuw LW, Stribinskis V, Trent JO. Human POT1 unfolds G-quadruplexes by conformational selection. Nucleic Acids Research. PMID 32232414 DOI: 10.1093/Nar/Gkaa202  0.801
2020 Monsen RC, DeLeeuw L, Dean WL, Gray RD, Sabo TM, Chakravarthy S, Chaires JB, Trent JO. The hTERT core promoter forms three parallel G-quadruplexes. Nucleic Acids Research. PMID 32083666 DOI: 10.1093/Nar/Gkaa107  0.787
2019 Mestre-Fos S, Penev PI, Richards JC, Dean WL, Gray RD, Chaires JB, Williams LD. Profusion of G-quadruplexes on both subunits of metazoan ribosomes. Plos One. 14: e0226177. PMID 31834895 DOI: 10.1371/Journal.Pone.0226177  0.372
2019 Dean WL, Gray RD, DeLeeuw L, Monsen RC, Chaires JB. Putting a New Spin of G-Quadruplex Structure and Binding by Analytical Ultracentrifugation. Methods in Molecular Biology (Clifton, N.J.). 2035: 87-103. PMID 31444745 DOI: 10.1007/978-1-4939-9666-7_5  0.783
2019 Gray RD, Trent JO, Arumugam S, Chaires JB. Folding Landscape of a Parallel G-Quadruplex. The Journal of Physical Chemistry Letters. 1146-1151. PMID 30802054 DOI: 10.1021/Acs.Jpclett.9B00227  0.33
2018 Zahin M, Dean WL, Ghim SJ, Joh J, Gray RD, Khanal S, Bossart GD, Mignucci-Giannoni AA, Rouchka EC, Jenson AB, Trent JO, Chaires JB, Chariker JH. Identification of G-quadruplex forming sequences in three manatee papillomaviruses. Plos One. 13: e0195625. PMID 29630682 DOI: 10.1371/Journal.Pone.0195625  0.403
2018 del Villar-Guerra R, Trent JO, Chaires JB. Back Cover: G-Quadruplex Secondary Structure Obtained from Circular Dichroism Spectroscopy (Angew. Chem. Int. Ed. 24/2018) Angewandte Chemie International Edition. 57: 7256-7256. DOI: 10.1002/anie.201712043  0.388
2018 del Villar-Guerra R, Trent JO, Chaires JB. Rücktitelbild: G-Quadruplex Secondary Structure Obtained from Circular Dichroism Spectroscopy (Angew. Chem. 24/2018) Angewandte Chemie. 130: 7376-7376. DOI: 10.1002/ange.201712043  0.403
2017 Rigo R, Dean WL, Gray RD, Chaires JB, Sissi C. Conformational profiling of a G-rich sequence within the c-KIT promoter. Nucleic Acids Research. PMID 29069417 DOI: 10.1093/Nar/Gkx983  0.41
2016 Bončina M, Vesnaver G, Chaires JB, Lah J. Unraveling the Thermodynamics of the Folding and Interconversion of Human Telomere G-Quadruplexes. Angewandte Chemie (International Ed. in English). PMID 27484724 DOI: 10.1002/anie.201605350  0.358
2015 Chaires JB, Dean WL, Le HT, Trent JO. Hydrodynamic Models of G-Quadruplex Structures. Methods in Enzymology. 562: 287-304. PMID 26412657 DOI: 10.1016/bs.mie.2015.04.011  0.405
2015 Chaires JB, Levene SD. Preface. Biopolymers. 103: 469. PMID 26015222 DOI: 10.1002/bip.22686  0.586
2015 Chaires JB, Levene SD. Preface. Biopolymers. 103: 417. PMID 26010347 DOI: 10.1002/bip.22661  0.586
2015 Miller DM, Sokolova A, Rezzoug F, Thomas S, Chaires J, Dean W, Trent J. Abstract PR02: Specific inhibition of hTERT expression in melanoma by targeting common promoter mutations which cause quadruplex DNA instability Cancer Research. 75. DOI: 10.1158/1538-7445.Mel2014-Pr02  0.309
2015 Chaires JB, Dean WL, Le HT, Trent JO. Hydrodynamic Models of G-Quadruplex Structures Methods in Enzymology. DOI: 10.1016/bs.mie.2015.04.011  0.382
2014 Le HT, Dean WL, Buscaglia R, Chaires JB, Trent JO. An investigation of G-quadruplex structural polymorphism in the human telomere using a combined approach of hydrodynamic bead modeling and molecular dynamics simulation. The Journal of Physical Chemistry. B. 118: 5390-405. PMID 24779348 DOI: 10.1021/jp502213y  0.433
2014 Gray RD, Trent JO, Chaires JB. Folding and unfolding pathways of the human telomeric G-quadruplex. Journal of Molecular Biology. 426: 1629-50. PMID 24487181 DOI: 10.1016/J.Jmb.2014.01.009  0.329
2013 Buscaglia R, Miller MC, Dean WL, Gray RD, Lane AN, Trent JO, Chaires JB. Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection. Nucleic Acids Research. 41: 7934-46. PMID 23804761 DOI: 10.1093/Nar/Gkt440  0.35
2013 Buscaglia R, Gray RD, Chaires JB. Thermodynamic characterization of human telomere quadruplex unfolding. Biopolymers. 99: 1006-18. PMID 23536479 DOI: 10.1002/Bip.22247  0.302
2013 Le HT, Buscaglia R, Dean WL, Chaires JB, Trent JO. Calculation of hydrodynamic properties for G-quadruplex nucleic acid structures from in silico bead models. Topics in Current Chemistry. 330: 179-210. PMID 22886555 DOI: 10.1007/128_2012_351  0.452
2013 Le HT, Buscaglia R, Dean WL, Chaires JB, Trent JO. Calculation of hydrodynamic properties for G-quadruplex nucleic acid structures from in silico bead models Topics in Current Chemistry. 330: 179-210. DOI: 10.1007/128-2012-351  0.308
2012 Le HT, Miller MC, Buscaglia R, Dean WL, Holt PA, Chaires JB, Trent JO. Not all G-quadruplexes are created equally: An investigation of the structural polymorphism of the c-Myc G-quadruplex-forming sequence and its interaction with the porphyrin TMPyP4 Organic and Biomolecular Chemistry. 10: 9393-9404. PMID 23108607 DOI: 10.1039/c2ob26504d  0.437
2012 Gray RD, Chaires JB. Isothermal folding of G-quadruplexes. Methods (San Diego, Calif.). 57: 47-55. PMID 22525787 DOI: 10.1016/J.Ymeth.2012.04.006  0.391
2012 Buscaglia R, Jameson DM, Chaires JB. G-quadruplex structure and stability illuminated by 2-aminopurine phasor plots. Nucleic Acids Research. 40: 4203-15. PMID 22241767 DOI: 10.1093/Nar/Gkr1286  0.321
2012 Buscaglia R, Jameson DM, Chaires JB. Phasor Diagram Analysis of Telomeric G-Quadruplex Stability and Heterogeneity Biophysical Journal. 102: 209a. DOI: 10.1016/J.Bpj.2011.11.1140  0.385
2011 Petraccone L, Spink C, Trent JO, Garbett NC, Mekmaysy CS, Giancola C, Chaires JB. Structure and stability of higher-order human telomeric quadruplexes Journal of the American Chemical Society. 133: 20951-20961. PMID 22082001 DOI: 10.1021/ja209192a  0.386
2011 Holt PA, Buscaglia R, Trent JO, Chaires JB. A Discovery Funnel for Nucleic Acid Binding Drug Candidates. Drug Development Research. 72: 178-186. PMID 21566705 DOI: 10.1002/ddr.20414  0.316
2010 Miller MC, Buscaglia R, Chaires JB, Lane AN, Trent JO. Hydration is a major determinant of the G-quadruplex stability and conformation of the human telomere 3′ sequence of d(AG 3(TTAG3)3) Journal of the American Chemical Society. 132: 17105-17107. PMID 21087016 DOI: 10.1021/ja105259m  0.339
2010 Wheelhouse RT, Garbett NC, Buurma NJ, Chaires JB. Probing the molecular recognition of a DNA.RNA hybrid duplex. Angewandte Chemie (International Ed. in English). 49: 3207-10. PMID 20352639 DOI: 10.1002/Anie.200907235  0.309
2010 Petraccone L, Garbett NC, Chaires JB, Trent JO. An integrated molecular dynamics (MD) and experimental study of higher order human telomeric quadruplexes Biopolymers. 93: 533-548. PMID 20095044 DOI: 10.1002/bip.21392  0.378
2010 Gray RD, Petraccone L, Trent JO, Chaires JB. Characterization of a K+-induced conformational switch in a human telomeric DNA oligonucleotide using 2-aminopurine fluorescence. Biochemistry. 49: 179-94. PMID 19961180 DOI: 10.1021/Bi901357R  0.327
2010 Chaires JB. Human telomeric G-quadruplex: Thermodynamic and kinetic studies of telomeric quadruplex stability Febs Journal. 277: 1098-1106. PMID 19951355 DOI: 10.1111/j.1742-4658.2009.07462.x  0.35
2009 Gray RD, Li J, Chaires JB. Energetics and kinetics of a conformational switch in G-quadruplex DNA Journal of Physical Chemistry B. 113: 2676-2683. DOI: 10.1021/jp809578f  0.375
2008 Lane AN, Chaires JB, Gray RD, Trent JO. Stability and kinetics of G-quadruplex structures. Nucleic Acids Research. 36: 5482-515. PMID 18718931 DOI: 10.1093/Nar/Gkn517  0.358
2008 Gray RD, Chaires JB. Kinetics and mechanism of K+- and Na+-induced folding of models of human telomeric DNA into G-quadruplex structures. Nucleic Acids Research. 36: 4191-203. PMID 18567908 DOI: 10.1093/Nar/Gkn379  0.321
2008 Mekmaysy CS, Petraccone L, Garbett NC, Ragazzon PA, Gray R, Trent JO, Chaires JB. Effect of O6-methylguanine on the stability of G-quadruplex DNA Journal of the American Chemical Society. 130: 6710-6711. PMID 18447358 DOI: 10.1021/Ja801976H  0.352
2007 Ragazzon P, Chaires JB. Use of competition dialysis in the discovery of G-quadruplex selective ligands Methods. 43: 313-323. PMID 17967701 DOI: 10.1016/j.ymeth.2007.08.003  0.455
2007 Bishop GR, Ren J, Polander BC, Jeanfreau BD, Trent JO, Chaires JB. Energetic basis of molecular recognition in a DNA aptamer Biophysical Chemistry. 126: 165-175. PMID 16914261 DOI: 10.1016/j.bpc.2006.07.009  0.317
2007 Freyer MW, Buscaglia R, Cashman D, Hyslop S, Wilson WD, Chaires JB, Lewis EA. Binding of netropsin to several DNA constructs: Evidence for at least two different 1:1 complexes formed from an -AATT-containing ds-DNA construct and a single minor groove binding ligand Biophysical Chemistry. 126: 186-196. PMID 16837123 DOI: 10.1016/J.Bpc.2006.06.009  0.342
2006 Chaires JB. A thermodynamic signature for drug-DNA binding mode. Archives of Biochemistry and Biophysics. 453: 26-31. PMID 16730635 DOI: 10.1016/j.abb.2006.03.027  0.33
2005 Portugal J, Cashman DJ, Trent JO, Ferrer-Miralles N, Przewloka T, Fokt I, Priebe W, Chaires JB. A new bisintercalating anthracycline with picomolar DNA binding affinity Journal of Medicinal Chemistry. 48: 8209-8219. PMID 16366602 DOI: 10.1021/Jm050902G  0.319
2003 Chaires JB. A competition dialysis assay for the study of structure-selective ligand binding to nucleic acids. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 8.3. PMID 18428915  0.326
2003 Leng F, Chaires JB, Waring MJ. Energetics of echinomycin binding to DNA Nucleic Acids Research. 31: 6191-6197. PMID 14576305 DOI: 10.1093/Nar/Gkg826  0.318
2003 Qu X, Ren J, Riccelli PV, Benight AS, Chaires JB. Enthalpy/Entropy Compensation: Influence of DNA Flanking Sequence on the Binding of 7-Amino Actinomycin D to its Primary Binding Site in Short DNA Duplexes Biochemistry. 42: 11960-11967. PMID 14556627 DOI: 10.1021/bi0347813  0.322
2002 Carrasco C, Rosu F, Gabelica V, Houssier C, De Pauw E, Garbay-Jaureguiberry C, Roques B, David Wilson W, Chaires JB, Waring MJ, Bailly C. Tight binding of the antitumor drug ditercalinium to quadruplex DNA Chembiochem. 3: 1235-1241. PMID 12465032 DOI: 10.1002/1439-7633(20021202)3:12<1235::Aid-Cbic1235>3.0.Co;2-I  0.393
2002 Ren J, Qu X, Trent JO, Chaires JB. Tiny telomere DNA Nucleic Acids Research. 30: 2307-2315. PMID 12034817  0.362
2001 Carrasco C, Vezin H, Wilson WD, Ren J, Chaires JB, Bailly C. DNA binding properties of the indolocarbazole antitumor drug NB-506 Anti-Cancer Drug Design. 16: 99-107. PMID 11962518  0.318
2001 Alberti P, Ren J, Teulade-Fichou MP, Guittat L, Riou JF, Chaires J, Hélène C, Vigneron JP, Lehn JM, Mergny JL. Interaction of an acridine dimer with DNA quadruplex structures. Journal of Biomolecular Structure & Dynamics. 19: 505-13. PMID 11790148 DOI: 10.1080/07391102.2001.10506758  0.402
2001 Priebe W, Fokt I, Przewloka T, Chaires JB, Portugal J, Trent JO. Exploiting anthracycline scaffold for designing DNA-targeting agents Methods in Enzymology. 340: 529-555. PMID 11494869 DOI: 10.1016/S0076-6879(01)40441-1  0.321
2001 Chaires JB. Analysis and interpretation of ligand-DNA binding isotherms. Methods in Enzymology. 340: 3-22. PMID 11494856 DOI: 10.1016/S0076-6879(01)40415-0  0.332
2001 Murr MM, Harting MT, Guelev V, Ren J, Chaires JB, Iverson BL. An octakis-intercalating molecule. Bioorganic & Medicinal Chemistry. 9: 1141-8. PMID 11377172 DOI: 10.1016/S0968-0896(00)00335-7  0.309
2000 Bailly C, Goossens JF, Laine W, Anizon F, Prudhomme M, Ren J, Chaires JB. Formaldehyde-induced alkylation of a 2'-aminoglucose rebeccamycin derivative to both A.T and G.C base pairs in DNA. Journal of Medicinal Chemistry. 43: 4711-20. PMID 11101362 DOI: 10.1021/jm0003438  0.358
2000 Ren J, Bailly C, Chaires JB. NB-506, an indolocarbazole topoisomerase I inhibitor, binds preferentially to triplex DNA Febs Letters. 470: 355-359. PMID 10745096 DOI: 10.1016/S0014-5793(00)01335-1  0.357
1999 Ren J, Chaires JB. Sequence and structural selectivity of nucleic acid binding ligands Biochemistry. 38: 16067-16075. PMID 10587429 DOI: 10.1021/bi992070s  0.369
1999 Bailly C, Qu X, Anizon F, Prudhomme M, Riou JF, Chaires JB. Enhanced binding to DNA and topoisomerase I inhibition by an analog of the antitumor antibiotic rebeccamycin containing an amino sugar residue Molecular Pharmacology. 55: 377-385. PMID 9927631  0.314
1998 Chaires JB. Drug-DNA interactions Current Opinion in Structural Biology. 8: 314-320. PMID 9666327 DOI: 10.1016/S0959-440X(98)80064-X  0.326
1998 Leng F, Priebe W, Chaires JB. Ultratight DNA binding of a new bisintercalating anthracycline antibiotic Biochemistry. 37: 1743-1753. PMID 9485299 DOI: 10.1021/Bi9720742  0.319
1998 Bailly C, Suh D, Waring MJ, Chaires JB. Binding of daunomycin to diaminopurine- and/or inosine-substituted DNA Biochemistry. 37: 1033-1045. PMID 9454594 DOI: 10.1021/Bi9716128  0.314
1997 Chaires JB. Energetics of drug-DNA interactions Biopolymers. 44: 201-215. PMID 9591476  0.365
1997 Robinson H, Priebe W, Chaires JB, Wang AHJ. Binding of two novel bisdaunorubicins to DNA studied by NMR spectroscopy Biochemistry. 36: 8663-8670. PMID 9289011 DOI: 10.1021/Bi970842J  0.358
1997 Haq I, Ladbury JE, Chowdhry BZ, Jenkins TC, Chaires JB. Specific binding of Hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: Calorimetric and spectroscopic studies Journal of Molecular Biology. 271: 244-257. PMID 9268656 DOI: 10.1006/jmbi.1997.1170  0.311
1997 Chaires JB, Leng F, Przewloka T, Fokt I, Ling YH, Perez-Soler R, Priebe W. Structure-based design of a new bisintercalating anthracycline antibiotic Journal of Medicinal Chemistry. 40: 261-266. PMID 9022792 DOI: 10.1021/Jm9607414  0.318
1995 Haq I, Lincoln P, Suh D, Norden B, Chowdhry BZ, Chaires JB. Interaction of .DELTA.- and .LAMBDA.-[Ru(phen)2DPPZ]2+ with DNA: A Calorimetric and Equilibrium Binding Study Journal of the American Chemical Society. 117: 4788-4796. DOI: 10.1021/Ja00122A008  0.319
1993 Chaires JB. Tris(phenanthroline)ruthenium(II) enantiomer interactions with DNA: Mode and specificity of binding Biochemistry. 32: 2573-2584. PMID 8448115 DOI: 10.1021/Bi00061A015  0.313
1991 Suh D, Sheardy RD, Chaires JB. Unusual binding of ethidium to a deoxyoligonucleotide containing a B-Z junction Biochemistry. 30: 8722-8726. PMID 1888733 DOI: 10.1021/Bi00100A002  0.323
1990 Chaires JB. Biophysical chemistry of the daunomycin-DNA interaction Biophysical Chemistry. 35: 191-202. PMID 2204442 DOI: 10.1016/0301-4622(90)80008-U  0.315
1988 Chaires JB, Norcum MT. Structure and stability of z* Dna Journal of Biomolecular Structure and Dynamics. 5: 1187-1207. PMID 3271507 DOI: 10.1080/07391102.1988.10506463  0.302
1987 Fritzsche H, Wähnert U, Chaires JB, Dattagupta N, Schlessinger FB, Crothers DM. Anthracycline antibiotics. Interaction with DNA and nucleosomes and inhibition of DNA synthesis. Biochemistry. 26: 1996-2000. PMID 3297138  0.547
1987 Chaires JB, Fox KR, Herrera JE, Britt M, Waring MJ. Site and sequence specificity of the daunomycin-DNA interaction. Biochemistry. 26: 8227-36. PMID 2831939 DOI: 10.1021/Bi00399A031  0.314
1985 Chaires JB. Long-range allosteric effects on the B to Z equilibrium by daunomycin Biochemistry. 24: 7479-7486. PMID 4084594  0.366
1985 Chaires JB, Dattagupta N, Crothers DM. Kinetics of the daunomycin--DNA interaction. Biochemistry. 24: 260-7. PMID 3978073 DOI: 10.1021/Bi00323A004  0.531
1983 Chaires JB, Dattagupta N, Crothers DM. Binding of daunomycin to calf thymus nucleosomes. Biochemistry. 22: 284-92. PMID 6824632 DOI: 10.1021/Bi00271A009  0.57
1982 Fritzsche H, Triebel H, Chaires JB, Dattagupta N, Crothers DM. Studies on interaction of anthracycline antibiotics and deoxyribonucleic acid: geometry of intercalation of iremycin and daunomycin. Biochemistry. 21: 3940-6. PMID 7126525 DOI: 10.1021/Bi00260A006  0.531
1982 Chaires JB, Dattagupta N, Crothers DM. Studies on interaction of anthracycline antibiotics and deoxyribonucleic acid: equilibrium binding studies on interaction of daunomycin with deoxyribonucleic acid. Biochemistry. 21: 3933-40. PMID 7126524 DOI: 10.1021/Bi00260A005  0.568
1982 Chaires JB, Dattagupta N, Crothers DM. Self-association of daunomycin. Biochemistry. 21: 3927-32. PMID 7126523 DOI: 10.1021/Bi00260A004  0.471
1982 Chaires JB, Dattagupta N, Crothers DM. The interaction of daunomycin with calf-thymus nucleosomes Federation Proceedings. 41: No. 5437.  0.427
1982 Fritzsche H, Chaires JB, Dattagupta N, Crothers DM. Interaction of anthracycline antibiotics to DNA and nucleosomes: A comparative study Studia Biophysica. 92: 67-68.  0.495
1981 Chaires JB, Dattagupta N, Crothers DM. The interaction of daunomycin with DNA Biophysical Journal. 33: W-AM-Po81.  0.5
1977 Chaires JB, Tai M, Huang C, Kegeles G, Infante AA, Wahba AJ. Relaxation kinetics of E. coli ribosomes Biophysical Chemistry. 7: 179-188. PMID 334276 DOI: 10.1016/0301-4622(77)87020-8  0.566
1977 Chaires JB, Kegeles G. Sucrose density gradient sedimentation of E. coli ribosomes Biophysical Chemistry. 7: 173-178. PMID 334275 DOI: 10.1016/0301-4622(77)87019-1  0.564
1975 Chaires JB, Kegeles G, Wahba AJ. Relaxation kinetics of E coli ribosomes: evidence for the reaction of 30S . IF3 complex with 50S ribosomal subunits. Biophysical Chemistry. 9: 405-12. PMID 16997206  0.59
1975 Chaires JB, Kegeles G, Wahba AJ. Relaxation kinetics of E coli ribosomes: evidence for the reaction of 30S · IF3 complex with 50s ribosomal subunits Biophysical Chemistry. 9: 405-412. PMID 380673 DOI: 10.1016/0301-4622(75)80056-1  0.591
1972 Noller HF, Chaires JB. Functional modification of 16S ribosomal RNA by kethoxal. Proceedings of the National Academy of Sciences of the United States of America. 69: 3115-8. PMID 4564202 DOI: 10.1073/Pnas.69.11.3115  0.448
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