| Year |
Citation |
Score |
| 2019 |
Sayed ME, Cheng A, Yadav GP, Ludlow AT, Shay JW, Wright WE, Jiang QX. Catalysis-dependent inactivation of human telomerase and its reactivation by intracellular telomerase-activating factors (iTAFs). The Journal of Biological Chemistry. PMID 31186347 DOI: 10.1074/Jbc.Ra118.007234 |
0.501 |
|
| 2019 |
Min J, Wright WE, Shay JW. Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52. Genes & Development. PMID 31171703 DOI: 10.1101/Gad.324905.119 |
0.485 |
|
| 2019 |
Zhang Z, Zhang T, Ge Y, Tang M, Ma W, Zhang Q, Gong S, Wright WE, Shay J, Liu H, Zhao Y. 2D gel electrophoresis reveals dynamics of t-loop formation during the cell cycle and t-loop in maintenance regulated by heterochromatin state. The Journal of Biological Chemistry. PMID 30819801 DOI: 10.1074/Jbc.Ra119.007677 |
0.433 |
|
| 2019 |
Shay JW, Wright WE. Telomeres and telomerase: three decades of progress. Nature Reviews. Genetics. PMID 30760854 DOI: 10.1038/S41576-019-0099-1 |
0.521 |
|
| 2018 |
Sayed ME, Yuan L, Robin JD, Tedone E, Batten K, Dahlson N, Wright WE, Shay JW, Ludlow AT. NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells. Oncogene. PMID 30568224 DOI: 10.1038/S41388-018-0639-8 |
0.511 |
|
| 2018 |
Tedone E, Huang E, O'Hara R, Batten K, Ludlow AT, Lai TP, Arosio B, Mari D, Wright WE, Shay JW. Telomere length and telomerase activity in T cells are biomarkers of high-performing centenarians. Aging Cell. e12859. PMID 30488553 DOI: 10.1111/Acel.12859 |
0.454 |
|
| 2018 |
Ludlow AT, Wong MS, Robin JD, Batten K, Yuan L, Lai TP, Dahlson N, Zhang L, Mender I, Tedone E, Sayed ME, Wright WE, Shay JW. NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer. Nature Communications. 9: 3112. PMID 30082712 DOI: 10.1038/S41467-018-05582-X |
0.511 |
|
| 2018 |
Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, Du W, Wu LF, Altschuler SJ, Brekken R, Martinez ED, ... ... Wright WE, et al. Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance. Neoplasia (New York, N.Y.). 20: 826-837. PMID 30015158 DOI: 10.1016/J.Neo.2018.06.002 |
0.462 |
|
| 2018 |
Kim SB, Zhang L, Yoon J, Lee J, Min J, Li W, Grishin NV, Moon YA, Wright WE, Shay JW. Truncated APC Mutation Induces Asef Activated Golgi Fragmentation. Molecular and Cellular Biology. PMID 29866653 DOI: 10.1128/Mcb.00135-18 |
0.512 |
|
| 2018 |
Ludlow AT, Shelton D, Wright WE, Shay JW. ddTRAP: A Method for Sensitive and Precise Quantification of Telomerase Activity. Methods in Molecular Biology (Clifton, N.J.). 1768: 513-529. PMID 29717462 DOI: 10.1007/978-1-4939-7778-9_29 |
0.537 |
|
| 2018 |
Lai TP, Wright WE, Shay JW. Comparison of telomere length measurement methods. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29335378 DOI: 10.1098/Rstb.2016.0451 |
0.511 |
|
| 2017 |
Lai TP, Zhang N, Noh J, Mender I, Tedone E, Huang E, Wright WE, Danuser G, Shay JW. A method for measuring the distribution of the shortest telomeres in cells and tissues. Nature Communications. 8: 1356. PMID 29116081 DOI: 10.1038/S41467-017-01291-Z |
0.516 |
|
| 2017 |
Min J, Wright WE, Shay JW. Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes. Molecular and Cellular Biology. PMID 28760773 DOI: 10.1128/Mcb.00226-17 |
0.547 |
|
| 2017 |
Huang EE, Tedone E, O'Hara R, Cornelius C, Lai TP, Ludlow A, Wright WE, Shay JW. The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation. Scientific Reports. 7: 6785. PMID 28754961 DOI: 10.1038/S41598-017-05174-7 |
0.477 |
|
| 2017 |
LaRanger R, Peters-Hall JR, Coquelin M, Alabi BR, Chen C, Wright WE, Shay J. Reconstituting Mouse Lungs with Conditionally Reprogrammed Human Bronchial Epithelial Cells. Tissue Engineering. Part A. PMID 28726588 DOI: 10.1089/Ten.Tea.2017.0114 |
0.427 |
|
| 2017 |
Zhao Y, Shay JW, Wright WE. Telomere Terminal G/C Strand Synthesis: Measuring Telomerase Action and C-Rich Fill-In. Methods in Molecular Biology (Clifton, N.J.). 1587: 71-82. PMID 28324499 DOI: 10.1007/978-1-4939-6892-3_7 |
0.57 |
|
| 2017 |
Zhao Y, Shay JW, Wright WE. Telomere G-Rich Overhang Length Measurement: DSN Method. Methods in Molecular Biology (Clifton, N.J.). 1587: 55-62. PMID 28324497 DOI: 10.1007/978-1-4939-6892-3_5 |
0.468 |
|
| 2017 |
Min J, Wright WE, Shay JW. Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands. Nucleic Acids Research. PMID 28082393 DOI: 10.1093/Nar/Gkw1295 |
0.582 |
|
| 2016 |
Kim W, Ludlow AT, Min J, Robin JD, Stadler G, Mender I, Lai TP, Zhang N, Wright WE, Shay JW. Regulation of the Human Telomerase Gene TERT by Telomere Position Effect-Over Long Distances (TPE-OLD): Implications for Aging and Cancer. Plos Biology. 14: e2000016. PMID 27977688 DOI: 10.1371/Journal.Pbio.2000016 |
0.575 |
|
| 2016 |
Zhang L, Theodoropoulos PC, Eskiocak U, Wang W, Moon YA, Posner B, Williams NS, Wright WE, Kim SB, Nijhawan D, De Brabander JK, Shay JW. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer. Science Translational Medicine. 8: 361ra140. PMID 27798265 DOI: 10.1126/Scitranslmed.Aaf8127 |
0.475 |
|
| 2016 |
Holohan B, Kim W, Lai TP, Hoshiyama H, Zhang N, Alazami AM, Wright WE, Meyn MS, Alkuraya FS, Shay JW. Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency. Bmc Genomics. 17: 749. PMID 27766953 DOI: 10.1186/S12864-016-3093-4 |
0.418 |
|
| 2016 |
Lai TP, Wright WE, Shay JW. Generation of digoxigenin-incorporated probes to enhance DNA detection sensitivity. Biotechniques. 60: 306-9. PMID 27286808 DOI: 10.2144/000114427 |
0.47 |
|
| 2016 |
Robin JD, Ludlow AT, LaRanger R, Wright WE, Shay JW. Comparison of DNA Quantification Methods for Next Generation Sequencing. Scientific Reports. 6: 24067. PMID 27048884 DOI: 10.1038/Srep24067 |
0.398 |
|
| 2016 |
Bhagwandin VJ, Bishop JM, Wright WE, Shay JW. The Metastatic Potential and Chemoresistance of Human Pancreatic Cancer Stem Cells. Plos One. 11: e0148807. PMID 26859746 DOI: 10.1371/Journal.Pone.0148807 |
0.488 |
|
| 2015 |
Robin JD, Ludlow AT, Batten K, Gaillard MC, Stadler G, Magdinier F, Wright WE, Shay JW. SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy. Genome Research. PMID 26359233 DOI: 10.1101/Gr.190660.115 |
0.482 |
|
| 2015 |
Holohan B, Hagiopian MM, Lai TP, Huang E, Friedman DR, Wright WE, Shay JW. Perifosine as a potential novel anti-telomerase therapy. Oncotarget. 6: 21816-26. PMID 26307677 DOI: 10.18632/Oncotarget.5200 |
0.501 |
|
| 2015 |
Holohan B, De Meyer T, Batten K, Mangino M, Hunt SC, Bekaert S, De Buyzere ML, Rietzschel ER, Spector TD, Wright WE, Shay JW. Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening. Aging Cell. PMID 25952108 DOI: 10.1111/Acel.12347 |
0.442 |
|
| 2015 |
Kulak O, Chen H, Holohan B, Wu X, He H, Borek D, Otwinowski Z, Yamaguchi K, Garofalo LA, Ma Z, Wright W, Chen C, Shay JW, Zhang X, Lum L. Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Molecular and Cellular Biology. 35: 2425-35. PMID 25939383 DOI: 10.1128/Mcb.00392-15 |
0.496 |
|
| 2015 |
Zhang L, Kim S, Jia G, Buhmeida A, Dallol A, Wright WE, Fornace AJ, Al-Qahtani M, Shay JW. Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis. Bmc Genomics. 16: S8. PMID 25923178 DOI: 10.1186/1471-2164-16-S1-S8 |
0.495 |
|
| 2015 |
Pandita RK, Chow TT, Udayakumar D, Bain AL, Cubeddu L, Hunt CR, Shi W, Horikoshi N, Zhao Y, Wright WE, Khanna KK, Shay JW, Pandita TK. Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Cancer Research. 75: 858-69. PMID 25589350 DOI: 10.1158/0008-5472.Can-14-2289 |
0.527 |
|
| 2015 |
Mender I, Gryaznov S, Dikmen ZG, Wright WE, Shay JW. Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine. Cancer Discovery. 5: 82-95. PMID 25516420 DOI: 10.1158/2159-8290.Cd-14-0609 |
0.598 |
|
| 2014 |
El-Ashmawy M, Delgado O, Cardentey A, Wright WE, Shay JW. CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation. Plos One. 9: e115600. PMID 25536195 DOI: 10.1371/Journal.Pone.0115600 |
0.499 |
|
| 2014 |
Robin JD, Ludlow AT, Batten K, Magdinier F, Stadler G, Wagner KR, Shay JW, Wright WE. Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances. Genes & Development. 28: 2464-76. PMID 25403178 DOI: 10.1101/Gad.251041.114 |
0.53 |
|
| 2014 |
Wong MS, Wright WE, Shay JW. Alternative splicing regulation of telomerase: a new paradigm? Trends in Genetics : Tig. 30: 430-8. PMID 25172021 DOI: 10.1016/J.Tig.2014.07.006 |
0.441 |
|
| 2014 |
Ludlow AT, Robin JD, Sayed M, Litterst CM, Shelton DN, Shay JW, Wright WE. Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolution. Nucleic Acids Research. 42: e104. PMID 24861623 DOI: 10.1093/Nar/Gku439 |
0.508 |
|
| 2014 |
Kaisani A, Delgado O, Fasciani G, Kim SB, Wright WE, Minna JD, Shay JW. Branching morphogenesis of immortalized human bronchial epithelial cells in three-dimensional culture. Differentiation; Research in Biological Diversity. 87: 119-26. PMID 24830354 DOI: 10.1016/J.Diff.2014.02.003 |
0.48 |
|
| 2014 |
Holohan B, Wright WE, Shay JW. Cell biology of disease: Telomeropathies: an emerging spectrum disorder. The Journal of Cell Biology. 205: 289-99. PMID 24821837 DOI: 10.1083/Jcb.201401012 |
0.401 |
|
| 2014 |
Singel SM, Cornelius C, Zaganjor E, Batten K, Sarode VR, Buckley DL, Peng Y, John GB, Li HC, Sadeghi N, Wright WE, Lum L, Corson TW, Shay JW. KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer. Neoplasia (New York, N.Y.). 16: 247-56, 256.e2. PMID 24784001 DOI: 10.1016/J.Neo.2014.03.008 |
0.445 |
|
| 2014 |
Singel SM, Batten K, Cornelius C, Jia G, Fasciani G, Barron SL, Wright WE, Shay JW. Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways. Breast Cancer Research : Bcr. 16: R28. PMID 24642040 DOI: 10.1186/Bcr3629 |
0.468 |
|
| 2014 |
Wong MS, Shay JW, Wright WE. Regulation of human telomerase splicing by RNA:RNA pairing. Nature Communications. 5: 3306. PMID 24577044 DOI: 10.1038/Ncomms4306 |
0.431 |
|
| 2014 |
Delgado O, Batten KG, Richardson JA, Xie XJ, Gazdar AF, Kaisani AA, Girard L, Behrens C, Suraokar M, Fasciani G, Wright WE, Story MD, Wistuba II, Minna JD, Shay JW. Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 1610-22. PMID 24486591 DOI: 10.1158/1078-0432.Ccr-13-2589 |
0.433 |
|
| 2013 |
Stadler G, King OD, Robin JD, Shay JW, Wright WE. Facioscapulohumeral muscular dystrophy: Are telomeres the end of the story? Rare Diseases (Austin, Tex.). 1: e26142. PMID 25003004 DOI: 10.4161/rdis.26142 |
0.491 |
|
| 2013 |
Kim SB, Ly P, Kaisani A, Zhang L, Wright WE, Shay JW. Mitigation of radiation-induced damage by targeting EGFR in noncancerous human epithelial cells. Radiation Research. 180: 259-67. PMID 23919312 DOI: 10.1667/Rr3371.1 |
0.456 |
|
| 2013 |
Stadler G, Rahimov F, King OD, Chen JC, Robin JD, Wagner KR, Shay JW, Emerson CP, Wright WE. Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy. Nature Structural & Molecular Biology. 20: 671-8. PMID 23644600 DOI: 10.1038/Nsmb.2571 |
0.555 |
|
| 2013 |
Wong MS, Chen L, Foster C, Kainthla R, Shay JW, Wright WE. Regulation of telomerase alternative splicing: a target for chemotherapy. Cell Reports. 3: 1028-35. PMID 23562158 DOI: 10.1016/J.Celrep.2013.03.011 |
0.474 |
|
| 2013 |
Singel SM, Cornelius C, Batten K, Fasciani G, Wright WE, Lum L, Shay JW. A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 2061-70. PMID 23479679 DOI: 10.1158/1078-0432.Ccr-13-0082 |
0.445 |
|
| 2013 |
Christodoulidou A, Raftopoulou C, Chiourea M, Papaioannou GK, Hoshiyama H, Wright WE, Shay JW, Gagos S. The roles of telomerase in the generation of polyploidy during neoplastic cell growth. Neoplasia (New York, N.Y.). 15: 156-68. PMID 23441130 DOI: 10.1593/Neo.121398 |
0.541 |
|
| 2013 |
Zhang L, Komurov K, Wright WE, Shay JW. Identification of novel driver tumor suppressors through functional interrogation of putative passenger mutations in colorectal cancer. International Journal of Cancer. Journal International Du Cancer. 132: 732-7. PMID 22753261 DOI: 10.1002/Ijc.27705 |
0.423 |
|
| 2012 |
Kim SB, Pandita RK, Eskiocak U, Ly P, Kaisani A, Kumar R, Cornelius C, Wright WE, Pandita TK, Shay JW. Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation. Proceedings of the National Academy of Sciences of the United States of America. 109: E2949-55. PMID 23045680 DOI: 10.1073/Pnas.1207718109 |
0.447 |
|
| 2012 |
Ly P, Eskiocak U, Parker CR, Harris KJ, Wright WE, Shay JW. RNAi screening of the human colorectal cancer genome identifies multifunctional tumor suppressors regulating epithelial cell invasion. Cell Research. 22: 1605-8. PMID 23044803 DOI: 10.1038/Cr.2012.140 |
0.465 |
|
| 2012 |
Shay JW, Reddel RR, Wright WE. Cancer. Cancer and telomeres--an ALTernative to telomerase. Science (New York, N.Y.). 336: 1388-90. PMID 22700908 DOI: 10.1126/Science.1222394 |
0.556 |
|
| 2012 |
Chow TT, Zhao Y, Mak SS, Shay JW, Wright WE. Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening. Genes & Development. 26: 1167-78. PMID 22661228 DOI: 10.1101/Gad.187211.112 |
0.505 |
|
| 2012 |
Hoshiyama H, Tang J, Batten K, Xiao G, Rouillard JM, Shay JW, Xie Y, Wright WE. Development of methods for quantitative comparison of pooled shRNAs by mass sequencing. Journal of Biomolecular Screening. 17: 258-65. PMID 21956173 DOI: 10.1177/1087057111423101 |
0.365 |
|
| 2011 |
Kim J, Eskiocak U, Stadler G, Lou Z, Kuro-o M, Shay JW, Wright WE. Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells. The Journal of Biological Chemistry. 286: 43294-300. PMID 22020932 DOI: 10.1074/Jbc.M111.267641 |
0.484 |
|
| 2011 |
Shay JW, Wright WE. Role of telomeres and telomerase in cancer. Seminars in Cancer Biology. 21: 349-53. PMID 22015685 DOI: 10.1016/J.Semcancer.2011.10.001 |
0.604 |
|
| 2011 |
Tennen RI, Bua DJ, Wright WE, Chua KF. SIRT6 is required for maintenance of telomere position effect in human cells. Nature Communications. 2: 433. PMID 21847107 DOI: 10.1038/Ncomms1443 |
0.343 |
|
| 2011 |
Stadler G, Chen JC, Wagner K, Robin JD, Shay JW, Emerson CP, Wright WE. Establishment of clonal myogenic cell lines from severely affected dystrophic muscles - CDK4 maintains the myogenic population. Skeletal Muscle. 1: 12. PMID 21798090 DOI: 10.1186/2044-5040-1-12 |
0.477 |
|
| 2011 |
Delgado O, Kaisani AA, Spinola M, Xie XJ, Batten KG, Minna JD, Wright WE, Shay JW. Multipotent capacity of immortalized human bronchial epithelial cells. Plos One. 6: e22023. PMID 21760947 DOI: 10.1371/Journal.Pone.0022023 |
0.487 |
|
| 2011 |
Zhao Y, Abreu E, Kim J, Stadler G, Eskiocak U, Terns MP, Terns RM, Shay JW, Wright WE. Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions. Molecular Cell. 42: 297-307. PMID 21549308 DOI: 10.1016/J.Molcel.2011.03.020 |
0.516 |
|
| 2011 |
Eskiocak U, Kim SB, Ly P, Roig AI, Biglione S, Komurov K, Cornelius C, Wright WE, White MA, Shay JW. Functional parsing of driver mutations in the colorectal cancer genome reveals numerous suppressors of anchorage-independent growth. Cancer Research. 71: 4359-65. PMID 21527559 DOI: 10.1158/0008-5472.Can-11-0794 |
0.436 |
|
| 2011 |
Gomes NM, Ryder OA, Houck ML, Charter SJ, Walker W, Forsyth NR, Austad SN, Venditti C, Pagel M, Shay JW, Wright WE. Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination. Aging Cell. 10: 761-8. PMID 21518243 DOI: 10.1111/J.1474-9726.2011.00718.X |
0.545 |
|
| 2011 |
Ly P, Eskiocak U, Kim SB, Roig AI, Hight SK, Lulla DR, Zou YS, Batten K, Wright WE, Shay JW. Characterization of aneuploid populations with trisomy 7 and 20 derived from diploid human colonic epithelial cells. Neoplasia (New York, N.Y.). 13: 348-57. PMID 21472139 DOI: 10.1593/Neo.101580 |
0.541 |
|
| 2011 |
Zhao Y, Shay JW, Wright WE. Telomere terminal G/C strand synthesis: measuring telomerase action and C-rich fill-in. Methods in Molecular Biology (Clifton, N.J.). 735: 63-75. PMID 21461812 DOI: 10.1007/978-1-61779-092-8_7 |
0.57 |
|
| 2011 |
Zhao Y, Shay JW, Wright WE. Telomere G-overhang length measurement method 1: the DSN method. Methods in Molecular Biology (Clifton, N.J.). 735: 47-54. PMID 21461810 DOI: 10.1007/978-1-61779-092-8_5 |
0.463 |
|
| 2011 |
Ouellette MM, Wright WE, Shay JW. Targeting telomerase-expressing cancer cells. Journal of Cellular and Molecular Medicine. 15: 1433-42. PMID 21332640 DOI: 10.1111/J.1582-4934.2011.01279.X |
0.479 |
|
| 2010 |
Joseph I, Tressler R, Bassett E, Harley C, Buseman CM, Pattamatta P, Wright WE, Shay JW, Go NF. The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines. Cancer Research. 70: 9494-504. PMID 21062983 DOI: 10.1158/0008-5472.Can-10-0233 |
0.533 |
|
| 2010 |
Eskiocak U, Kim SB, Roig AI, Kitten E, Batten K, Cornelius C, Zou YS, Wright WE, Shay JW. CDDO-Me protects against space radiation-induced transformation of human colon epithelial cells. Radiation Research. 174: 27-36. PMID 20681796 DOI: 10.1667/Rr2155.1 |
0.467 |
|
| 2010 |
Gomes NM, Shay JW, Wright WE. Telomere biology in Metazoa. Febs Letters. 584: 3741-51. PMID 20655915 DOI: 10.1016/J.Febslet.2010.07.031 |
0.475 |
|
| 2010 |
Shay JW, Wright WE. Telomeres and telomerase in normal and cancer stem cells. Febs Letters. 584: 3819-25. PMID 20493857 DOI: 10.1016/J.Febslet.2010.05.026 |
0.517 |
|
| 2010 |
Marian CO, Cho SK, McEllin BM, Maher EA, Hatanpaa KJ, Madden CJ, Mickey BE, Wright WE, Shay JW, Bachoo RM. The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 154-63. PMID 20048334 DOI: 10.1158/1078-0432.Ccr-09-2850 |
0.473 |
|
| 2010 |
Roig AI, Eskiocak U, Hight SK, Kim SB, Delgado O, Souza RF, Spechler SJ, Wright WE, Shay JW. Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro. Gastroenterology. 138: 1012-21.e1-5. PMID 19962984 DOI: 10.1053/J.Gastro.2009.11.052 |
0.519 |
|
| 2010 |
Atzmon G, Cho M, Cawthon RM, Budagov T, Katz M, Yang X, Siegel G, Bergman A, Huffman DM, Schechter CB, Wright WE, Shay JW, Barzilai N, Govindaraju DR, Suh Y. Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proceedings of the National Academy of Sciences of the United States of America. 107: 1710-7. PMID 19915151 DOI: 10.1073/Pnas.0906191106 |
0.466 |
|
| 2010 |
Marian CO, Wright WE, Shay JW. The effects of telomerase inhibition on prostate tumor-initiating cells. International Journal of Cancer. Journal International Du Cancer. 127: 321-31. PMID 19908230 DOI: 10.1002/Ijc.25043 |
0.432 |
|
| 2009 |
Lou Z, Wei J, Riethman H, Baur JA, Voglauer R, Shay JW, Wright WE. Telomere length regulates ISG15 expression in human cells. Aging. 1: 608-21. PMID 20157543 |
0.571 |
|
| 2009 |
Vaughan MB, Ramirez RD, Andrews CM, Wright WE, Shay JW. H-ras expression in immortalized keratinocytes produces an invasive epithelium in cultured skin equivalents. Plos One. 4: e7908. PMID 19936293 DOI: 10.1371/Journal.Pone.0007908 |
0.737 |
|
| 2009 |
Zhao Y, Sfeir AJ, Zou Y, Buseman CM, Chow TT, Shay JW, Wright WE. Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells. Cell. 138: 463-75. PMID 19665970 DOI: 10.1016/J.Cell.2009.05.026 |
0.553 |
|
| 2009 |
Matsuo T, Shay JW, Wright WE, Hiyama E, Shimose S, Kubo T, Sugita T, Yasunaga Y, Ochi M. Telomere-maintenance mechanisms in soft-tissue malignant fibrous histiocytomas. The Journal of Bone and Joint Surgery. American Volume. 91: 928-37. PMID 19339578 DOI: 10.2106/Jbjs.G.01390 |
0.432 |
|
| 2009 |
Zou Y, Misri S, Shay JW, Pandita TK, Wright WE. Altered states of telomere deprotection and the two-stage mechanism of replicative aging. Molecular and Cellular Biology. 29: 2390-7. PMID 19223460 DOI: 10.1128/Mcb.01569-08 |
0.499 |
|
| 2008 |
Zhu CH, Kim J, Shay JW, Wright WE. SGNP: an essential Stress Granule/Nucleolar Protein potentially involved in 5.8s rRNA processing/transport. Plos One. 3: e3716. PMID 19005571 DOI: 10.1371/Journal.Pone.0003716 |
0.387 |
|
| 2008 |
Zhao Y, Hoshiyama H, Shay JW, Wright WE. Quantitative telomeric overhang determination using a double-strand specific nuclease. Nucleic Acids Research. 36: e14. PMID 18073199 DOI: 10.1093/Nar/Gkm1063 |
0.454 |
|
| 2008 |
Dikmen ZG, Wright WE, Shay JW, Gryaznov SM. Telomerase targeted oligonucleotide thio-phosphoramidates in T24-luc bladder cancer cells. Journal of Cellular Biochemistry. 104: 444-52. PMID 18044713 DOI: 10.1002/Jcb.21635 |
0.501 |
|
| 2007 |
Natarajan S, Chow TT, Shay JW, Wright WE. Replica plating of mammalian cells using low melt agarose. Cytotechnology. 54: 145-7. PMID 19003006 DOI: 10.1007/S10616-007-9071-6 |
0.442 |
|
| 2007 |
Gryaznov SM, Jackson S, Dikmen G, Harley C, Herbert BS, Wright WE, Shay JW. Oligonucleotide conjugate GRN163L targeting human telomerase as potential anticancer and antimetastatic agent. Nucleosides, Nucleotides & Nucleic Acids. 26: 1577-9. PMID 18066830 DOI: 10.1080/15257770701547271 |
0.481 |
|
| 2007 |
Garcia CK, Wright WE, Shay JW. Human diseases of telomerase dysfunction: insights into tissue aging. Nucleic Acids Research. 35: 7406-16. PMID 17913752 DOI: 10.1093/Nar/Gkm644 |
0.444 |
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| 2007 |
Shay JW, Wright WE. Tissue culture as a hostile environment: identifying conditions for breast cancer progression studies. Cancer Cell. 12: 100-1. PMID 17692800 DOI: 10.1016/J.Ccr.2007.07.012 |
0.482 |
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| 2007 |
Zhu CH, Mouly V, Cooper RN, Mamchaoui K, Bigot A, Shay JW, Di Santo JP, Butler-Browne GS, Wright WE. Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies. Aging Cell. 6: 515-23. PMID 17559502 DOI: 10.1111/J.1474-9726.2007.00306.X |
0.522 |
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| 2007 |
Gardner JP, Kimura M, Chai W, Durrani JF, Tchakmakjian L, Cao X, Lu X, Li G, Peppas AP, Skurnick J, Wright WE, Shay JW, Aviv A. Telomere dynamics in macaques and humans. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 62: 367-74. PMID 17452729 DOI: 10.1093/Gerona/62.4.367 |
0.496 |
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| 2007 |
Jackson SR, Zhu CH, Paulson V, Watkins L, Dikmen ZG, Gryaznov SM, Wright WE, Shay JW. Antiadhesive effects of GRN163L--an oligonucleotide N3'->P5' thio-phosphoramidate targeting telomerase. Cancer Research. 67: 1121-9. PMID 17283146 DOI: 10.1158/0008-5472.Can-06-2306 |
0.521 |
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| 2006 |
Wright WE, Shay JW. Inexpensive low-oxygen incubators. Nature Protocols. 1: 2088-90. PMID 17487199 DOI: 10.1038/Nprot.2006.374 |
0.381 |
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| 2006 |
Herbert BS, Hochreiter AE, Wright WE, Shay JW. Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol. Nature Protocols. 1: 1583-90. PMID 17406450 DOI: 10.1038/Nprot.2006.239 |
0.415 |
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| 2006 |
Shay JW, Wright WE. Telomerase therapeutics for cancer: challenges and new directions. Nature Reviews. Drug Discovery. 5: 577-84. PMID 16773071 DOI: 10.1038/Nrd2081 |
0.505 |
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| 2006 |
Vaughan MB, Ramirez RD, Wright WE, Minna JD, Shay JW. A three-dimensional model of differentiation of immortalized human bronchial epithelial cells. Differentiation; Research in Biological Diversity. 74: 141-8. PMID 16683984 DOI: 10.1111/J.1432-0436.2006.00069.X |
0.787 |
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| 2006 |
Chai W, Du Q, Shay JW, Wright WE. Human telomeres have different overhang sizes at leading versus lagging strands. Molecular Cell. 21: 427-35. PMID 16455497 DOI: 10.1016/J.Molcel.2005.12.004 |
0.564 |
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| 2006 |
Chai W, Sfeir AJ, Hoshiyama H, Shay JW, Wright WE. The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. Embo Reports. 7: 225-30. PMID 16374507 DOI: 10.1038/Sj.Embor.7400600 |
0.535 |
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| 2006 |
Gellert GC, Dikmen ZG, Wright WE, Gryaznov S, Shay JW. Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer. Breast Cancer Research and Treatment. 96: 73-81. PMID 16319992 DOI: 10.1007/S10549-005-9043-5 |
0.546 |
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| 2005 |
Shay JW, Wright WE. Use of telomerase to create bioengineered tissues. Annals of the New York Academy of Sciences. 1057: 479-91. PMID 16399914 DOI: 10.1196/Annals.1356.037 |
0.58 |
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| 2005 |
Sfeir AJ, Shay JW, Wright WE. Fine-tuning the chromosome ends: the last base of human telomeres. Cell Cycle (Georgetown, Tex.). 4: 1467-70. PMID 16258279 DOI: 10.4161/Cc.4.11.2161 |
0.516 |
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| 2005 |
Dikmen ZG, Gellert GC, Jackson S, Gryaznov S, Tressler R, Dogan P, Wright WE, Shay JW. In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Research. 65: 7866-73. PMID 16140956 DOI: 10.1158/0008-5472.Can-05-1215 |
0.506 |
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| 2005 |
Takakura M, Kyo S, Inoue M, Wright WE, Shay JW. Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells. Molecular and Cellular Biology. 25: 8037-43. PMID 16135795 DOI: 10.1128/Mcb.25.18.8037-8043.2005 |
0.457 |
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| 2005 |
Wright WE, Shay JW. Telomere biology in aging and cancer. Journal of the American Geriatrics Society. 53: S292-4. PMID 16131355 DOI: 10.1111/J.1532-5415.2005.53492.X |
0.554 |
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| 2005 |
Hockemeyer D, Sfeir AJ, Shay JW, Wright WE, de Lange T. POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. The Embo Journal. 24: 2667-78. PMID 15973431 DOI: 10.1038/Sj.Emboj.7600733 |
0.531 |
|
| 2005 |
Aviv A, Shay J, Christensen K, Wright W. The longevity gender gap: are telomeres the explanation? Science of Aging Knowledge Environment : Sage Ke. 2005: pe16. PMID 15944464 DOI: 10.1126/Sageke.2005.23.Pe16 |
0.41 |
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| 2005 |
Herbert BS, Gellert GC, Hochreiter A, Pongracz K, Wright WE, Zielinska D, Chin AC, Harley CB, Shay JW, Gryaznov SM. Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition. Oncogene. 24: 5262-8. PMID 15940257 DOI: 10.1038/Sj.Onc.1208760 |
0.54 |
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| 2005 |
Forsyth NR, Elder FF, Shay JW, Wright WE. Lagomorphs (rabbits, pikas and hares) do not use telomere-directed replicative aging in vitro. Mechanisms of Ageing and Development. 126: 685-91. PMID 15888323 DOI: 10.1016/J.Mad.2005.01.003 |
0.502 |
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| 2005 |
Sfeir AJ, Chai W, Shay JW, Wright WE. Telomere-end processing the terminal nucleotides of human chromosomes. Molecular Cell. 18: 131-8. PMID 15808515 DOI: 10.1016/J.Molcel.2005.02.035 |
0.483 |
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| 2005 |
Chai W, Shay JW, Wright WE. Human telomeres maintain their overhang length at senescence. Molecular and Cellular Biology. 25: 2158-68. PMID 15743814 DOI: 10.1128/Mcb.25.6.2158-2168.2005 |
0.532 |
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| 2005 |
Hofer AC, Tran RT, Aziz OZ, Wright W, Novelli G, Shay J, Lewis M. Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 60: 10-20. PMID 15741277 DOI: 10.1093/Gerona/60.1.10 |
0.412 |
|
| 2005 |
Wright WE, Shay JW. Telomere-binding factors and general DNA repair. Nature Genetics. 37: 116-8. PMID 15678140 DOI: 10.1038/Ng0205-116 |
0.437 |
|
| 2005 |
Robertson DM, Li L, Fisher S, Pearce VP, Shay JW, Wright WE, Cavanagh HD, Jester JV. Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line. Investigative Ophthalmology & Visual Science. 46: 470-8. PMID 15671271 DOI: 10.1167/Iovs.04-0528 |
0.532 |
|
| 2005 |
Shay JW, Wright WE. Mechanism-based combination telomerase inhibition therapy. Cancer Cell. 7: 1-2. PMID 15652743 DOI: 10.1016/J.Ccr.2004.12.012 |
0.494 |
|
| 2005 |
Shay JW, Wright WE. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis. 26: 867-74. PMID 15471900 DOI: 10.1093/Carcin/Bgh296 |
0.577 |
|
| 2004 |
Ramirez RD, Sheridan S, Girard L, Sato M, Kim Y, Pollack J, Peyton M, Zou Y, Kurie JM, Dimaio JM, Milchgrub S, Smith AL, Souza RF, Gilbey L, Zhang X, ... ... Wright WE, et al. Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Research. 64: 9027-34. PMID 15604268 DOI: 10.1158/0008-5472.Can-04-3703 |
0.791 |
|
| 2004 |
Zou Y, Gryaznov SM, Shay JW, Wright WE, Cornforth MN. Asynchronous replication timing of telomeres at opposite arms of mammalian chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 101: 12928-33. PMID 15322275 DOI: 10.1073/Pnas.0404106101 |
0.463 |
|
| 2004 |
Vaughan MB, Ramirez RD, Brown SA, Yang JC, Wright WE, Shay JW. A reproducible laser-wounded skin equivalent model to study the effects of aging in vitro. Rejuvenation Research. 7: 99-110. PMID 15312297 DOI: 10.1089/1549168041552982 |
0.72 |
|
| 2004 |
Baur JA, Wright WE, Shay JW. Analysis of mammalian telomere position effect. Methods in Molecular Biology (Clifton, N.J.). 287: 121-36. PMID 15273408 DOI: 10.1385/1-59259-828-5:121 |
0.523 |
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| 2004 |
Zou Y, Sfeir A, Gryaznov SM, Shay JW, Wright WE. Does a sentinel or a subset of short telomeres determine replicative senescence? Molecular Biology of the Cell. 15: 3709-18. PMID 15181152 DOI: 10.1091/Mbc.E04-03-0207 |
0.553 |
|
| 2004 |
Forsyth NR, Morales CP, Damle S, Boman B, Wright WE, Kopelovich L, Shay JW. Spontaneous immortalization of clinically normal colon-derived fibroblasts from a familial adenomatous polyposis patient. Neoplasia (New York, N.Y.). 6: 258-65. PMID 15153338 DOI: 10.1593/Neo.04103 |
0.545 |
|
| 2004 |
Bechter OE, Zou Y, Walker W, Wright WE, Shay JW. Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition. Cancer Research. 64: 3444-51. PMID 15150096 DOI: 10.1158/0008-5472.Can-04-0323 |
0.555 |
|
| 2004 |
Shay JW, Wright WE. Telomeres are double-strand DNA breaks hidden from DNA damage responses. Molecular Cell. 14: 420-1. PMID 15149591 DOI: 10.1016/S1097-2765(04)00269-2 |
0.481 |
|
| 2004 |
Steinert S, Shay JW, Wright WE. Modification of subtelomeric DNA. Molecular and Cellular Biology. 24: 4571-80. PMID 15121873 DOI: 10.1128/Mcb.24.10.4571-4580.2004 |
0.422 |
|
| 2004 |
Shay JW, Wright WE. Telomeres in dyskeratosis congenita. Nature Genetics. 36: 437-8. PMID 15118675 DOI: 10.1038/Ng0504-437 |
0.427 |
|
| 2004 |
Bechter OE, Shay JW, Wright WE. The frequency of homologous recombination in human ALT cells. Cell Cycle (Georgetown, Tex.). 3: 547-9. PMID 15034305 DOI: 10.4161/Cc.3.5.850 |
0.523 |
|
| 2004 |
Walter M, Forsyth NR, Wright WE, Shay JW, Roth MG. The establishment of telomerase-immortalized Tangier disease cell lines indicates the existence of an apolipoprotein A-I-inducible but ABCA1-independent cholesterol efflux pathway. The Journal of Biological Chemistry. 279: 20866-73. PMID 15001567 DOI: 10.1074/Jbc.M401714200 |
0.469 |
|
| 2004 |
Baur JA, Shay JW, Wright WE. Spontaneous reactivation of a silent telomeric transgene in a human cell line. Chromosoma. 112: 240-6. PMID 14735368 DOI: 10.1007/S00412-003-0269-X |
0.528 |
|
| 2003 |
Herbert BS, Shay JW, Wright WE. Analysis of telomeres and telomerase. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 18.6. PMID 18228424 DOI: 10.1002/0471143030.Cb1806S20 |
0.548 |
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| 2003 |
Bechter OE, Zou Y, Shay JW, Wright WE. Homologous recombination in human telomerase-positive and ALT cells occurs with the same frequency. Embo Reports. 4: 1138-43. PMID 14618159 DOI: 10.1038/Sj.Embor.7400027 |
0.519 |
|
| 2003 |
Forsyth NR, Evans AP, Shay JW, Wright WE. Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell. 2: 235-43. PMID 14570231 DOI: 10.1046/J.1474-9728.2003.00057.X |
0.443 |
|
| 2003 |
Jester JV, Huang J, Fisher S, Spiekerman J, Chang JH, Wright WE, Shay JW. Myofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblasts. Investigative Ophthalmology & Visual Science. 44: 1850-8. PMID 12714615 DOI: 10.1167/Iovs.02-0973 |
0.492 |
|
| 2003 |
Herbert BS, Pearce VP, Hynan LS, LaRue DM, Wright WE, Kopelovich L, Shay JW. A peroxisome proliferator-activated receptor-gamma agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells. Cancer Research. 63: 1914-9. PMID 12702583 |
0.491 |
|
| 2003 |
Ramirez RD, Herbert BS, Vaughan MB, Zou Y, Gandia K, Morales CP, Wright WE, Shay JW. Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells Oncogene. 22: 433-444. PMID 12545164 DOI: 10.1038/Sj.Onc.1206046 |
0.786 |
|
| 2002 |
Zou Y, Yi X, Wright WE, Shay JW. Human telomerase can immortalize Indian muntjac cells Experimental Cell Research. 281: 63-76. PMID 12441130 DOI: 10.1006/Excr.2002.5645 |
0.572 |
|
| 2002 |
Herbert BS, Wright WE, Shay JW. p16INK4a inactivation is not required to immortalize human mammary epithelial cells Oncogene. 21: 7897-7900. PMID 12420227 DOI: 10.1038/Sj.Onc.1205902 |
0.477 |
|
| 2002 |
Shay JW, Wright WE. Telomerase: A target for cancer therapeutics Cancer Cell. 2: 257-265. PMID 12398889 DOI: 10.1016/S1535-6108(02)00159-9 |
0.444 |
|
| 2002 |
Chai W, Ford LP, Lenertz L, Wright WE, Shay JW. Human Ku70/80 associates physically with telomerase through interaction with hTERT. The Journal of Biological Chemistry. 277: 47242-7. PMID 12377759 DOI: 10.1074/Jbc.M208542200 |
0.526 |
|
| 2002 |
Cong YS, Wright WE, Shay JW. Human telomerase and its regulation Microbiology and Molecular Biology Reviews. 66: 407-425. PMID 12208997 DOI: 10.1128/Mmbr.66.3.407-425.2002 |
0.554 |
|
| 2002 |
Wright WE, Shay JW. Historical claims and current interpretations of replicative aging Nature Biotechnology. 20: 682-688. PMID 12089552 DOI: 10.1038/Nbt0702-682 |
0.507 |
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| 2002 |
Ford LP, Wright WE, Shay JW. A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation Oncogene. 21: 580-583. PMID 11850782 DOI: 10.1038/Sj.Onc.1205086 |
0.507 |
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| 2002 |
Forsyth NR, Wright WE, Shay JW. Telomerase and differentiation in multicellular organisms: Turn it off, turn it on, and turn it off again Differentiation. 69: 188-197. PMID 11841477 DOI: 10.1046/J.1432-0436.2002.690412.X |
0.538 |
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| 2002 |
Granger MP, Wright WE, Shay JW. Telomerase in cancer and aging. Critical Reviews in Oncology/Hematology. 41: 29-40. PMID 11796230 DOI: 10.1016/S1040-8428(01)00188-3 |
0.543 |
|
| 2002 |
Aisner DL, Wright WE, Shay JW. Telomerase regulation: Not just flipping the switch Current Opinion in Genetics and Development. 12: 80-85. PMID 11790559 DOI: 10.1016/S0959-437X(01)00268-4 |
0.433 |
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| 2002 |
Steinert S, White DM, Zou Y, Shay JW, Wright WE. Telomere biology and cellular aging in nonhuman primate cells. Experimental Cell Research. 272: 146-52. PMID 11777339 DOI: 10.1006/Excr.2001.5409 |
0.555 |
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