| Year |
Citation |
Score |
| 2024 |
Tong Y, Zhang P, Yang X, Liu X, Zhang J, Grudniewska M, Jung I, Abegg D, Liu J, Childs-Disney JL, Gibaut QMR, Haniff HS, Adibekian A, Mouradian MM, Disney MD. Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera. Proceedings of the National Academy of Sciences of the United States of America. 121: e2306682120. PMID 38181056 DOI: 10.1073/pnas.2306682120 |
0.744 |
|
| 2023 |
Komlosh PG, Chen JL, Childs-Disney J, Disney MD, Canaani D. Broad-spectrum metastasis suppressing compounds and therapeutic uses thereof in human tumors. Scientific Reports. 13: 20420. PMID 37990044 DOI: 10.1038/s41598-023-47478-x |
0.654 |
|
| 2023 |
Springer NA, Meyer SM, Taghavi A, Benhamou RI, Tong Y, Childs-Disney JL, Disney MD. Methods for the study of ribonuclease targeting chimeras (RiboTACs). Methods in Enzymology. 692: 249-298. PMID 37925183 DOI: 10.1016/bs.mie.2023.06.006 |
0.735 |
|
| 2023 |
Meyer SM, Tanaka T, Taghavi A, Baisden JT, Grefe M, Disney MD. Optimization of a Protein-Targeted Medicine into an RNA-Specific Small Molecule. Acs Chemical Biology. 18: 2336-2342. PMID 37870980 DOI: 10.1021/acschembio.3c00476 |
0.576 |
|
| 2023 |
Suresh BM, Tong Y, Abegg D, Adibekian A, Childs-Disney JL, Disney MD. Altering the Cleaving Effector in Chimeric Molecules that Target RNA Enhances Cellular Selectivity. Acs Chemical Biology. PMID 37824291 DOI: 10.1021/acschembio.3c00363 |
0.788 |
|
| 2023 |
Gibaut QMR, Bush JA, Tong Y, Baisden JT, Taghavi A, Olafson H, Yao X, Childs-Disney JL, Wang ET, Disney MD. Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG) Degrader in Myotonic Dystrophy. Acs Central Science. 9: 1342-1353. PMID 37521782 DOI: 10.1021/acscentsci.2c01223 |
0.796 |
|
| 2023 |
Tong Y, Lee Y, Liu X, Childs-Disney JL, Suresh BM, Benhamou RI, Yang C, Li W, Costales MG, Haniff HS, Sievers S, Abegg D, Wegner T, Paulisch TO, Lekah E, ... ... Disney MD, et al. Programming inactive RNA-binding small molecules into bioactive degraders. Nature. PMID 37225982 DOI: 10.1038/s41586-023-06091-8 |
0.814 |
|
| 2023 |
Taghavi A, Baisden JT, Childs-Disney JL, Yildirim I, Disney MD. Conformational dynamics of RNA G4C2 and G2C4 repeat expansions causing ALS/FTD using NMR and molecular dynamics studies. Nucleic Acids Research. PMID 37216594 DOI: 10.1093/nar/gkad403 |
0.658 |
|
| 2023 |
Suresh BM, Taghavi A, Childs-Disney JL, Disney MD. Fragment-Based Approaches to Identify RNA Binders. Journal of Medicinal Chemistry. PMID 37186875 DOI: 10.1021/acs.jmedchem.3c00034 |
0.795 |
|
| 2023 |
Tong Y, Gibaut QMR, Rouse W, Childs-Disney JL, Suresh BM, Abegg D, Choudhary S, Akahori Y, Adibekian A, Moss WN, Disney MD. Correction to "Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of mRNA". Journal of the American Chemical Society. PMID 37058601 DOI: 10.1021/jacs.3c02644 |
0.82 |
|
| 2022 |
Bush JA, Meyer SM, Fuerst R, Tong Y, Li Y, Benhamou RI, Aikawa H, Zanon PRA, Gibaut QMR, Angelbello AJ, Gendron TF, Zhang YJ, Petrucelli L, Heick Jensen T, Childs-Disney JL, ... Disney MD, et al. A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(GC) in c9ALS/FTD via the nuclear RNA exosome. Proceedings of the National Academy of Sciences of the United States of America. 119: e2210532119. PMID 36409902 DOI: 10.1073/pnas.2210532119 |
0.8 |
|
| 2022 |
Gibaut QMR, Akahori Y, Bush JA, Taghavi A, Tanaka T, Aikawa H, Ryan LS, Paegel BM, Disney MD. Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion. Journal of the American Chemical Society. PMID 36399603 DOI: 10.1021/jacs.2c08883 |
0.446 |
|
| 2022 |
Meyer SM, Tanaka T, Zanon PRA, Baisden JT, Abegg D, Yang X, Akahori Y, Alshakarchi Z, Cameron MD, Adibekian A, Disney MD. DNA-Encoded Library Screening To Inform Design of a Ribonuclease Targeting Chimera (RiboTAC). Journal of the American Chemical Society. PMID 36342850 DOI: 10.1021/jacs.2c07217 |
0.465 |
|
| 2022 |
Suresh BM, Akahori Y, Taghavi A, Crynen G, Gibaut QMR, Li Y, Disney MD. Low-Molecular Weight Small Molecules Can Potently Bind RNA and Affect Oncogenic Pathways in Cells. Journal of the American Chemical Society. PMID 36322830 DOI: 10.1021/jacs.2c08770 |
0.573 |
|
| 2022 |
Childs-Disney JL, Yang X, Gibaut QMR, Tong Y, Batey RT, Disney MD. Targeting RNA structures with small molecules. Nature Reviews. Drug Discovery. PMID 35941229 DOI: 10.1038/s41573-022-00521-4 |
0.798 |
|
| 2022 |
Tong Y, Gibaut QMR, Rouse W, Childs-Disney JL, Suresh BM, Abegg D, Choudhary S, Akahori Y, Adibekian A, Moss WN, Disney MD. . Journal of the American Chemical Society. 144: 11620-11625. PMID 35737519 DOI: 10.1021/jacs.2c01929 |
0.86 |
|
| 2022 |
Yang X, Childs-Disney JL, Disney MD. A meditation on accelerating the development of small molecule medicines targeting RNA. Expert Opinion On Drug Discovery. 1-3. PMID 35658797 DOI: 10.1080/17460441.2022.2084528 |
0.784 |
|
| 2022 |
Benhamou RI, Suresh BM, Tong Y, Cochrane WG, Cavett V, Vezina-Dawod S, Abegg D, Childs-Disney JL, Adibekian A, Paegel BM, Disney MD. DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35110406 DOI: 10.1073/pnas.2114971119 |
0.723 |
|
| 2022 |
Ye F, Haniff HS, Suresh BM, Yang D, Zhang P, Crynen G, Teijaro CN, Yan W, Abegg D, Adibekian A, Shen B, Disney MD. Rational Approach to Identify RNA Targets of Natural Products Enables Identification of Nocathiacin as an Inhibitor of an Oncogenic RNA. Acs Chemical Biology. PMID 35044149 DOI: 10.1021/acschembio.1c00952 |
0.673 |
|
| 2022 |
Benhamou RI, Choudhary S, Lekah E, Tong Y, Disney MD. Bioinformatic Searching for Optimal RNA Targets of Dimeric Compounds Informs Design of a MicroRNA-27a Inhibitor. Acs Chemical Biology. 17: 5-10. PMID 34898169 DOI: 10.1021/acschembio.1c00395 |
0.403 |
|
| 2021 |
Bush JA, Aikawa H, Fuerst R, Li Y, Ursu A, Meyer SM, Benhamou RI, Chen JL, Khan T, Wagner-Griffin S, Van Meter MJ, Tong Y, Olafson H, McKee KK, Childs-Disney JL, ... ... Disney MD, et al. Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(GC) repeat expansion in vitro and in vivo ALS models. Science Translational Medicine. 13: eabd5991. PMID 34705518 DOI: 10.1126/scitranslmed.abd5991 |
0.651 |
|
| 2021 |
Ursu A, Baisden JT, Bush JA, Taghavi A, Choudhary S, Zhang YJ, Gendron TF, Petrucelli L, Yildirim I, Disney MD. A Small Molecule Exploits Hidden Structural Features within the RNA Repeat Expansion That Causes c9ALS/FTD and Rescues Pathological Hallmarks. Acs Chemical Neuroscience. 12: 4076-4089. PMID 34677935 DOI: 10.1021/acschemneuro.1c00470 |
0.486 |
|
| 2021 |
Zhang P, Liu X, Abegg D, Tanaka T, Tong Y, Benhamou RI, Baisden J, Crynen G, Meyer SM, Cameron MD, Chatterjee AK, Adibekian A, Childs-Disney JL, Disney MD. Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment. Journal of the American Chemical Society. PMID 34387474 DOI: 10.1021/jacs.1c02248 |
0.778 |
|
| 2021 |
Disney MD. A Few Revolutions of the RNA World in ACS Publications. Journal of the American Chemical Society. PMID 34369145 DOI: 10.1021/jacs.1c06885 |
0.418 |
|
| 2021 |
Haniff HS, Liu X, Tong Y, Meyer SM, Knerr L, Lemurell M, Abegg D, Aikawa H, Adibekian A, Disney MD. A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype. Cell Chemical Biology. PMID 34320373 DOI: 10.1016/j.chembiol.2021.07.006 |
0.317 |
|
| 2021 |
Bush JA, Williams CC, Meyer SM, Tong Y, Haniff HS, Childs-Disney JL, Disney MD. Systematically Studying the Effect of Small Molecules Interacting with RNA in Cellular and Preclinical Models. Acs Chemical Biology. PMID 34166593 DOI: 10.1021/acschembio.1c00014 |
0.791 |
|
| 2021 |
Vezina-Dawod S, Angelbello AJ, Choudhary S, Wang KW, Yildirim I, Disney MD. Massively Parallel Optimization of the Linker Domain in Small Molecule Dimers Targeting a Toxic r(CUG) Repeat Expansion. Acs Medicinal Chemistry Letters. 12: 907-914. PMID 34141068 DOI: 10.1021/acsmedchemlett.1c00027 |
0.515 |
|
| 2021 |
Baisden JT, Childs-Disney JL, Ryan LS, Disney MD. Affecting RNA biology genome-wide by binding small molecules and chemically induced proximity. Current Opinion in Chemical Biology. 62: 119-129. PMID 34118759 DOI: 10.1016/j.cbpa.2021.03.006 |
0.791 |
|
| 2021 |
Disney MD. A glimpse at the glycoRNA world. Cell. 184: 3080-3081. PMID 34115968 DOI: 10.1016/j.cell.2021.05.025 |
0.386 |
|
| 2021 |
Wagner-Griffin S, Abe M, Benhamou RI, Angelbello AJ, Vishnu K, Chen JL, Childs-Disney JL, Disney MD. A Druglike Small Molecule that Targets r(CCUG) Repeats in Myotonic Dystrophy Type 2 Facilitates Degradation by RNA Quality Control Pathways. Journal of Medicinal Chemistry. PMID 34101465 DOI: 10.1021/acs.jmedchem.1c00414 |
0.793 |
|
| 2021 |
Andrews RJ, O'Leary CA, Tompkins VS, Peterson JM, Haniff HS, Williams C, Disney MD, Moss WN. A map of the SARS-CoV-2 RNA structurome. Nar Genomics and Bioinformatics. 3: lqab043. PMID 34046592 DOI: 10.1093/nargab/lqab043 |
0.761 |
|
| 2020 |
Suresh BM, Li W, Zhang P, Wang KW, Yildirim I, Parker CG, Disney MD. A general fragment-based approach to identify and optimize bioactive ligands targeting RNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 33318191 DOI: 10.1073/pnas.2012217117 |
0.488 |
|
| 2020 |
Ursu A, Wang KW, Bush JA, Choudhary S, Chen JL, Baisden JT, Zhang YJ, Gendron TF, Petrucelli L, Yildirim I, Disney MD. Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD. Acs Chemical Biology. PMID 33196168 DOI: 10.1021/acschembio.0c00049 |
0.389 |
|
| 2020 |
Angelbello AJ, Benhamou RI, Rzuczek SG, Choudhary S, Tang Z, Chen JL, Roy M, Wang KW, Yildirim I, Jun AS, Thornton CA, Disney MD. A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex. Cell Chemical Biology. PMID 33157036 DOI: 10.1016/j.chembiol.2020.10.007 |
0.549 |
|
| 2020 |
Haniff HS, Tong Y, Liu X, Chen JL, Suresh BM, Andrews RJ, Peterson JM, O'Leary CA, Benhamou RI, Moss WN, Disney MD. Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders. Acs Central Science. 6: 1713-1721. PMID 33140033 DOI: 10.1021/acscentsci.0c00984 |
0.783 |
|
| 2020 |
Meyer SM, Williams CC, Akahori Y, Tanaka T, Aikawa H, Tong Y, Childs-Disney JL, Disney MD. Small molecule recognition of disease-relevant RNA structures. Chemical Society Reviews. PMID 32975549 DOI: 10.1039/d0cs00560f |
0.812 |
|
| 2020 |
Ursu A, Childs-Disney JL, Andrews RJ, O'Leary CA, Meyer SM, Angelbello AJ, Moss WN, Disney MD. Design of small molecules targeting RNA structure from sequence. Chemical Society Reviews. PMID 32935689 DOI: 10.1039/D0Cs00455C |
0.868 |
|
| 2020 |
Haniff HS, Knerr L, Liu X, Crynen G, Boström J, Abegg D, Adibekian A, Lekah E, Wang KW, Cameron MD, Yildirim I, Lemurell M, Disney MD. Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions. Nature Chemistry. PMID 32839603 DOI: 10.1038/S41557-020-0514-4 |
0.585 |
|
| 2020 |
Benhamou RI, Abe M, Choudhary S, Meyer SM, Angelbello AJ, Disney MD. Optimization of the Linker Domain in a Dimeric Compound that Degrades an r(CUG) Repeat Expansion in Cells. Journal of Medicinal Chemistry. PMID 32657583 DOI: 10.1021/Acs.Jmedchem.0C00558 |
0.545 |
|
| 2020 |
Benhamou R, Vezina-Dawod S, Choudhary S, Wang KW, Meyer SM, Yildirim I, Disney M. Macrocyclization of a ligand targeting a toxic RNA dramatically improves potency. Chembiochem : a European Journal of Chemical Biology. PMID 32649032 DOI: 10.1002/Cbic.202000445 |
0.64 |
|
| 2020 |
Ursu A, Childs-Disney JL, Angelbello AJ, Costales MG, Meyer SM, Disney MD. Gini coefficients as a single value metric to define chemical probe selectivity. Acs Chemical Biology. PMID 32568503 DOI: 10.1021/Acschembio.0C00486 |
0.771 |
|
| 2020 |
Angelbello AJ, Disney MD. A Toxic RNA Templates the Synthesis of Its Own Fluorogenic Inhibitor by Using a Bio-orthogonal Tetrazine Ligation in Cells and Tissues. Acs Chemical Biology. PMID 32551539 DOI: 10.1021/Acschembio.0C00417 |
0.569 |
|
| 2020 |
Andrews RJ, Peterson JM, Haniff HS, Chen J, Williams C, Grefe M, Disney MD, Moss WN. An map of the SARS-CoV-2 RNA Structurome. Biorxiv : the Preprint Server For Biology. PMID 32511381 DOI: 10.1101/2020.04.17.045161 |
0.775 |
|
| 2020 |
Haniff HS, Knerr L, Chen JL, Disney MD, Lightfoot HL. Target-Directed Approaches for Screening Small Molecules against RNA Targets. Slas Discovery : Advancing Life Sciences R & D. 2472555220922802. PMID 32419578 DOI: 10.1177/2472555220922802 |
0.559 |
|
| 2020 |
Todd TW, McEachin ZT, Chew J, Burch AR, Jansen-West K, Tong J, Yue M, Song Y, Castanedes-Casey M, Kurti A, Dunmore JH, Fryer JD, Zhang YJ, San Millan B, Teijeira Bautista S, ... ... Disney MD, et al. Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo. Cell Reports. 31: 107616. PMID 32375043 DOI: 10.1016/J.Celrep.2020.107616 |
0.432 |
|
| 2020 |
Chen JL, Zhang P, Abe M, Aikawa H, Zhang L, Frank AJ, Zembryski T, Hubbs C, Park H, Withka J, Steppan C, Rogers L, Cabral S, Pettersson M, Wager TT, ... ... Disney MD, et al. Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing. Journal of the American Chemical Society. PMID 32364710 DOI: 10.1021/Jacs.0C00768 |
0.745 |
|
| 2020 |
Liu X, Haniff HS, Childs-Disney JL, Shuster A, Aikawa H, Adibekian A, Disney MD. Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands. Journal of the American Chemical Society. PMID 32233464 DOI: 10.1021/Jacs.9B13159 |
0.712 |
|
| 2020 |
Costales MG, Childs-Disney JL, Haniff HS, Disney MD. How We Think about Targeting RNA with Small Molecules. Journal of Medicinal Chemistry. PMID 32212706 DOI: 10.1021/Acs.Jmedchem.9B01927 |
0.817 |
|
| 2020 |
Angelbello AJ, DeFeo ME, Glinkerman CM, Boger DL, Disney MD. Precise Targeted Cleavage of a r(CUG) Repeat Expansion in Cells by Using a Small-Molecule-Deglycobleomycin Conjugate. Acs Chemical Biology. PMID 32186845 DOI: 10.1021/Acschembio.0C00036 |
0.536 |
|
| 2020 |
Disney MD, Suresh BM, Benhamou RI, Childs-Disney JL. Progress toward the development of the small molecule equivalent of small interfering RNA. Current Opinion in Chemical Biology. 56: 63-71. PMID 32036231 DOI: 10.1016/J.Cbpa.2020.01.001 |
0.824 |
|
| 2020 |
Benhamou RI, Angelbello AJ, Wang ET, Disney MD. A Toxic RNA Catalyzes the Cellular Synthesis of Its Own Inhibitor, Shunting It to Endogenous Decay Pathways. Cell Chemical Biology. PMID 31981476 DOI: 10.1016/J.Chembiol.2020.01.003 |
0.536 |
|
| 2020 |
Costales MG, Aikawa H, Li Y, Childs-Disney JL, Abegg D, Hoch DG, Pradeep Velagapudi S, Nakai Y, Khan T, Wang KW, Yildirim I, Adibekian A, Wang ET, Disney MD. Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 31964809 DOI: 10.1073/Pnas.1914286117 |
0.814 |
|
| 2020 |
Benhamou RI, Angelbello AJ, Andrews RJ, Wang ET, Moss WN, Disney MD. Structure-Specific Cleavage of an RNA Repeat Expansion with a Dimeric Small Molecule Is Advantageous over Sequence-Specific Recognition by an Oligonucleotide. Acs Chemical Biology. PMID 31927948 DOI: 10.1021/Acschembio.9B00958 |
0.795 |
|
| 2020 |
Zhang P, Park HJ, Zhang J, Junn E, Andrews RJ, Velagapudi SP, Abegg D, Vishnu K, Costales MG, Childs-Disney JL, Adibekian A, Moss WN, Mouradian MM, Disney MD. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 31900363 DOI: 10.1073/Pnas.1905057117 |
0.792 |
|
| 2019 |
Ursu A, Vézina-Dawod S, Disney MD. Methods to identify and optimize small molecules interacting with RNA (SMIRNAS). Drug Discovery Today. PMID 31356880 DOI: 10.1016/J.Drudis.2019.06.019 |
0.628 |
|
| 2019 |
Chen JL, Moss WN, Spencer A, Zhang P, Childs-Disney JL, Disney MD. The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology. Plos One. 14: e0219210. PMID 31291322 DOI: 10.1371/Journal.Pone.0219210 |
0.808 |
|
| 2019 |
Disney MD, Velagapudi SP, Li Y, Costales MG, Childs-Disney JL. Identifying and validating small molecules interacting with RNA (SMIRNAs). Methods in Enzymology. 623: 45-66. PMID 31239057 DOI: 10.1016/Bs.Mie.2019.04.027 |
0.827 |
|
| 2019 |
O'Leary CA, Andrews RJ, Tompkins VS, Chen JL, Childs-Disney JL, Disney MD, Moss WN. RNA structural analysis of the MYC mRNA reveals conserved motifs that affect gene expression. Plos One. 14: e0213758. PMID 31206539 DOI: 10.1371/Journal.Pone.0213758 |
0.802 |
|
| 2019 |
Costales MG, Suresh B, Vishnu K, Disney MD. Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA. Cell Chemical Biology. PMID 31130520 DOI: 10.1016/J.Chembiol.2019.04.008 |
0.634 |
|
| 2019 |
Costales MG, Disney MD. Adding Broccoli to the Biosensor Menu. Cell Chemical Biology. 26: 463-465. PMID 31002799 DOI: 10.1016/J.Chembiol.2019.04.004 |
0.381 |
|
| 2019 |
Velagapudi SP, Li Y, Disney MD. A cross-linking approach to map small molecule-RNA binding sites in cells. Bioorganic & Medicinal Chemistry Letters. PMID 30987892 DOI: 10.1016/J.Bmcl.2019.04.001 |
0.62 |
|
| 2019 |
Angelbello AJ, Chen JL, Disney MD. Small molecule targeting of RNA structures in neurological disorders. Annals of the New York Academy of Sciences. PMID 30964958 DOI: 10.1111/Nyas.14051 |
0.632 |
|
| 2019 |
Angelbello AJ, Rzuczek SG, Mckee KK, Chen JL, Olafson H, Cameron MD, Moss WN, Wang ET, Disney MD. Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model. Proceedings of the National Academy of Sciences of the United States of America. PMID 30926669 DOI: 10.1073/Pnas.1901484116 |
0.781 |
|
| 2019 |
Disney MD. Perspectives on targeting RNA with small molecules to capture opportunities at the intersection of chemistry, biology, and medicine. Journal of the American Chemical Society. PMID 30896935 DOI: 10.1021/Jacs.8B13419 |
0.626 |
|
| 2019 |
Chew J, Cook C, Gendron TF, Jansen-West K, Del Rosso G, Daughrity LM, Castanedes-Casey M, Kurti A, Stankowski JN, Disney MD, Rothstein JD, Dickson DW, Fryer JD, Zhang YJ, Petrucelli L. Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy. Molecular Neurodegeneration. 14: 9. PMID 30767771 DOI: 10.1186/S13024-019-0310-Z |
0.472 |
|
| 2019 |
Costales MG, Hoch DG, Abegg D, Childs-Disney JL, Velagapudi SP, Adibekian A, Disney MD. A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin. Journal of the American Chemical Society. PMID 30726072 DOI: 10.1021/Jacs.8B10558 |
0.696 |
|
| 2018 |
Childs-Disney JL, Tran T, Vummidi BR, Velagapudi SP, Haniff HS, Matsumoto Y, Crynen G, Southern MR, Biswas A, Wang ZF, Tellinghuisen TL, Disney MD. A Massively Parallel Selection of Small Molecule-RNA Motif Binding Partners Informs Design of an Antiviral from Sequence. Chem. 4: 2384-2404. PMID 30719503 DOI: 10.1016/J.Chempr.2018.08.003 |
0.811 |
|
| 2018 |
Wales DJ, Disney MD, Yildirim I. Computational Investigation of RNA A-Bulges Related to Microtubule-Associated Protein Tau Causing Frontotemporal Dementia and Parkinsonism. The Journal of Physical Chemistry. B. PMID 30517788 DOI: 10.1021/Acs.Jpcb.8B09139 |
0.516 |
|
| 2018 |
Wang ZF, Ursu A, Childs-Disney JL, Guertler R, Yang WY, Bernat V, Rzuczek SG, Fuerst R, Zhang YJ, Gendron TF, Yildirim I, Dwyer BG, Rice JE, Petrucelli L, Disney MD. The Hairpin Form of r(GC) in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules. Cell Chemical Biology. PMID 30503283 DOI: 10.1016/J.Chembiol.2018.10.018 |
0.835 |
|
| 2018 |
Disney MD, Dwyer BG, Childs-Disney JL. Drugging the RNA World. Cold Spring Harbor Perspectives in Biology. 10. PMID 30385607 DOI: 10.1101/Cshperspect.A034769 |
0.82 |
|
| 2018 |
Li Y, Disney MD. Precise Small Molecule Degradation of a Noncoding RNA Identifies Cellular Binding Sites and Modulates an Oncogenic Phenotype. Acs Chemical Biology. PMID 30375843 DOI: 10.1021/Acschembio.8B00827 |
0.528 |
|
| 2018 |
Velagapudi SP, Costales MG, Vummidi BR, Nakai Y, Angelbello AJ, Tran T, Haniff HS, Matsumoto Y, Wang ZF, Chatterjee AK, Childs-Disney JL, Disney MD. Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs. Cell Chemical Biology. 25: 1086-1094.e7. PMID 30251629 DOI: 10.1016/J.Chembiol.2018.05.015 |
0.788 |
|
| 2018 |
Haniff HS, Graves A, Disney MD. Selective Small Molecule Recognition of RNA Base Pairs. Acs Combinatorial Science. PMID 29966095 DOI: 10.1021/Acscombsci.8B00049 |
0.649 |
|
| 2018 |
Costales MG, Matsumoto Y, Velagapudi SP, Disney MD. Small Molecule Targeted Recruitment of a Nuclease to RNA. Journal of the American Chemical Society. PMID 29792692 DOI: 10.1021/Jacs.8B01233 |
0.553 |
|
| 2018 |
Angelbello AJ, Chen JL, Childs-Disney JL, Zhang P, Wang ZF, Disney MD. Using Genome Sequence to Enable the Design of Medicines and Chemical Probes. Chemical Reviews. PMID 29322778 DOI: 10.1021/Acs.Chemrev.7B00504 |
0.711 |
|
| 2017 |
Disney M, Angelbello A. Bleomycin can cleave an oncogenic non-coding RNA. Chembiochem : a European Journal of Chemical Biology. PMID 29084369 DOI: 10.1002/Cbic.201700581 |
0.56 |
|
| 2017 |
Guan L, Luo Y, Ja WW, Disney MD. Small molecule alteration of RNA sequence in cells and animals. Bioorganic & Medicinal Chemistry Letters. PMID 29079470 DOI: 10.1016/J.Bmcl.2017.10.034 |
0.636 |
|
| 2017 |
Chen JL, VanEtten DM, Fountain MA, Yildirim I, Disney MD. Structure and dynamics of RNA repeat expansions that cause Huntington's Disease and myotonic dystrophy type 1. Biochemistry. PMID 28617590 DOI: 10.1021/Acs.Biochem.7B00252 |
0.538 |
|
| 2017 |
Disney MD. Inhibiting Translation One Protein at a Time. Trends in Biochemical Sciences. 42: 412-413. PMID 28522328 DOI: 10.1016/J.Tibs.2017.04.008 |
0.351 |
|
| 2017 |
Velagapudi SP, Luo Y, Tran T, Haniff HS, Nakai Y, Fallahi M, Martinez GJ, Childs-Disney JL, Disney MD. Defining RNA-Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA. Acs Central Science. 3: 205-216. PMID 28386598 DOI: 10.1021/Acscentsci.7B00009 |
0.797 |
|
| 2017 |
Gendron TF, Chew J, Stankowski JN, Hayes LR, Zhang YJ, Prudencio M, Carlomagno Y, Daughrity LM, Jansen-West K, Perkerson EA, O'Raw A, Cook C, Pregent L, Belzil V, van Blitterswijk M, ... ... Disney MD, et al. Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis. Science Translational Medicine. 9. PMID 28356511 DOI: 10.1126/Scitranslmed.Aai7866 |
0.537 |
|
| 2017 |
Costales MG, Haga CL, Velagapudi SP, Childs-Disney JL, Phinney DG, Disney MD. Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit. Journal of the American Chemical Society. PMID 28240549 DOI: 10.1021/Jacs.6B11273 |
0.767 |
|
| 2017 |
Haga CL, Velagapudi SP, Childs-Disney JL, Strivelli J, Disney MD, Phinney DG. Rapid Generation of miRNA Inhibitor Leads by Bioinformatics and Efficient High-Throughput Screening Methods. Methods in Molecular Biology (Clifton, N.J.). 1517: 179-198. PMID 27924483 DOI: 10.1007/978-1-4939-6563-2_13 |
0.686 |
|
| 2016 |
Disney MD, Angelbello AJ. Rational Design of Small Molecules Targeting Oncogenic Noncoding RNAs from Sequence. Accounts of Chemical Research. 49: 2698-2704. PMID 27993012 DOI: 10.1021/Acs.Accounts.6B00326 |
0.669 |
|
| 2016 |
Rzuczek SG, Colgan LA, Nakai Y, Cameron MD, Furling D, Yasuda R, Disney MD. Precise small-molecule recognition of a toxic CUG RNA repeat expansion. Nature Chemical Biology. PMID 27941760 DOI: 10.1038/Nchembio.2251 |
0.629 |
|
| 2016 |
Angelbello AJ, González ÀL, Rzuczek SG, Disney MD. Development of pharmacophore models for small molecules targeting RNA: Application to the RNA repeat expansion in myotonic dystrophy type 1. Bioorganic & Medicinal Chemistry Letters. PMID 27839685 DOI: 10.1016/J.Bmcl.2016.10.037 |
0.629 |
|
| 2016 |
Park H, Tran T, Lee JH, Park H, Disney MD. Controlled dehydration improves the diffraction quality of two RNA crystals. Bmc Structural Biology. 16: 19. PMID 27809904 DOI: 10.1186/S12900-016-0069-1 |
0.379 |
|
| 2016 |
Rzuczek SG, Park H, Disney MD. Corrigendum: A Toxic RNA Catalyzes the In Cellulo Synthesis of Its Own Inhibitor. Angewandte Chemie (International Ed. in English). 55: 9817. PMID 27503420 DOI: 10.1002/Anie.201605756 |
0.528 |
|
| 2016 |
Yang WY, He F, Strack RL, Oh SY, Frazer M, Jaffrey SR, Todd PK, Disney MD. Small Molecule Recognition and Tools to Study Modulation of r(CGG)exp in Fragile X-Associated Tremor Ataxia Syndrome. Acs Chemical Biology. PMID 27276216 DOI: 10.1021/Acschembio.6B00147 |
0.612 |
|
| 2016 |
Yang WY, Gao R, Southern M, Sarkar PS, Disney MD. Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10. Nature Communications. 7: 11647. PMID 27248057 DOI: 10.1038/Ncomms11647 |
0.667 |
|
| 2016 |
Velagapudi SP, Cameron MD, Haga CL, Rosenberg LH, Lafitte M, Duckett DR, Phinney DG, Disney MD. Design of a small molecule against an oncogenic noncoding RNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 27170187 DOI: 10.1073/Pnas.1523975113 |
0.535 |
|
| 2016 |
Costales MG, Rzuczek SG, Disney MD. Comparison of small molecules and oligonucleotides that target a toxic, non-coding RNA. Bioorganic & Medicinal Chemistry Letters. PMID 27117425 DOI: 10.1016/J.Bmcl.2016.04.025 |
0.643 |
|
| 2016 |
Disney MD, Winkelsas AM, Velagapudi SP, Southern M, Fallahi M, Childs-Disney JL. Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs. Acs Chemical Biology. PMID 27097021 DOI: 10.1021/Acschembio.6B00001 |
0.827 |
|
| 2016 |
Liu B, Childs-Disney JL, Znosko BM, Wang D, Fallahi M, Gallo SM, Disney MD. Analysis of secondary structural elements in human microRNA hairpin precursors. Bmc Bioinformatics. 17: 112. PMID 26928172 DOI: 10.1186/S12859-016-0960-6 |
0.666 |
|
| 2016 |
Rzuczek SG, Park H, Disney MD. Berichtigung: A Toxic RNA Catalyzes the In Cellulo Synthesis of Its Own Inhibitor Angewandte Chemie. 128: 9971-9971. DOI: 10.1002/Ange.201605756 |
0.528 |
|
| 2015 |
Childs-Disney JL, Disney MD. Small Molecule Targeting of a MicroRNA Associated with Hepatocellular Carcinoma in Cellulo. Acs Chemical Biology. PMID 26551630 DOI: 10.1021/Acschembio.5B00615 |
0.698 |
|
| 2015 |
Childs-Disney JL, Disney MD. Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells. Annual Review of Pharmacology and Toxicology. PMID 26514201 DOI: 10.1146/Annurev-Pharmtox-010715-103910 |
0.804 |
|
| 2015 |
Yildirim I, Chakraborty D, Disney MD, Wales DJ, Schatz GC. Computational Investigation of RNA CUG Repeats Responsible for Myotonic Dystrophy 1. Journal of Chemical Theory and Computation. 11: 4943-4958. PMID 26500461 DOI: 10.1021/Acs.Jctc.5B00728 |
0.481 |
|
| 2015 |
Rzuczek SG, Southern MR, Disney MD. Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy. Acs Chemical Biology. PMID 26414664 DOI: 10.1021/Acschembio.5B00430 |
0.631 |
|
| 2015 |
Haga CL, Velagapudi SP, Strivelli JR, Yang WY, Disney MD, Phinney DG. Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling. Acs Chemical Biology. PMID 26181590 DOI: 10.1021/Acschembio.5B00265 |
0.421 |
|
| 2015 |
Bernat V, Disney MD. RNA Structures as Mediators of Neurological Diseases and as Drug Targets. Neuron. 87: 28-46. PMID 26139368 DOI: 10.1016/J.Neuron.2015.06.012 |
0.84 |
|
| 2015 |
Park H, González ÀL, Yildirim I, Tran T, Lohman JR, Fang P, Guo M, Disney MD. Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10). Biochemistry. 54: 3851-9. PMID 26039897 DOI: 10.1021/Acs.Biochem.5B00551 |
0.516 |
|
| 2015 |
Yang WY, Wilson HD, Velagapudi SP, Disney MD. Inhibition of Non-ATG Translational Events in Cells via Covalent Small Molecules Targeting RNA. Journal of the American Chemical Society. 137: 5336-45. PMID 25825793 DOI: 10.1021/Ja507448Y |
0.658 |
|
| 2015 |
Velagapudi SP, Vummidi BR, Disney MD. Small molecule chemical probes of microRNA function. Current Opinion in Chemical Biology. 24: 97-103. PMID 25500006 DOI: 10.1016/J.Cbpa.2014.10.024 |
0.451 |
|
| 2014 |
Su Z, Zhang Y, Gendron TF, Bauer PO, Chew J, Yang WY, Fostvedt E, Jansen-West K, Belzil VV, Desaro P, Johnston A, Overstreet K, Oh SY, Todd PK, Berry JD, ... ... Disney MD, et al. Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS. Neuron. 84: 239. PMID 28898625 DOI: 10.1016/J.Neuron.2014.09.019 |
0.389 |
|
| 2014 |
Rzuczek SG, Park H, Disney MD. A toxic RNA catalyzes the in cellulo synthesis of its own inhibitor. Angewandte Chemie (International Ed. in English). 53: 10956-9. PMID 25164984 DOI: 10.1002/Anie.201406465 |
0.564 |
|
| 2014 |
Su Z, Zhang Y, Gendron TF, Bauer PO, Chew J, Yang WY, Fostvedt E, Jansen-West K, Belzil VV, Desaro P, Johnston A, Overstreet K, Oh SY, Todd PK, Berry JD, ... ... Disney MD, et al. Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS. Neuron. 83: 1043-50. PMID 25132468 DOI: 10.1016/J.Neuron.2014.07.041 |
0.452 |
|
| 2014 |
Luo Y, Disney MD. Bottom-up design of small molecules that stimulate exon 10 skipping in mutant MAPT pre-mRNA. Chembiochem : a European Journal of Chemical Biology. 15: 2041-4. PMID 25115866 DOI: 10.1002/Cbic.201402069 |
0.576 |
|
| 2014 |
Hoskins JW, Ofori LO, Chen CZ, Kumar A, Sobczak K, Nakamori M, Southall N, Patnaik S, Marugan JJ, Zheng W, Austin CP, Disney MD, Miller BL, Thornton CA. Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects. Nucleic Acids Research. 42: 6591-602. PMID 24799433 DOI: 10.1093/Nar/Gku275 |
0.62 |
|
| 2014 |
Colak D, Zaninovic N, Cohen MS, Rosenwaks Z, Yang WY, Gerhardt J, Disney MD, Jaffrey SR. Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome. Science (New York, N.Y.). 343: 1002-5. PMID 24578575 DOI: 10.1126/Science.1245831 |
0.446 |
|
| 2014 |
Velagapudi SP, Gallo SM, Disney MD. Sequence-based design of bioactive small molecules that target precursor microRNAs. Nature Chemical Biology. 10: 291-7. PMID 24509821 DOI: 10.1038/Nchembio.1452 |
0.576 |
|
| 2014 |
Tran T, Childs-Disney JL, Liu B, Guan L, Rzuczek S, Disney MD. Targeting the r(CGG) repeats that cause FXTAS with modularly assembled small molecules and oligonucleotides. Acs Chemical Biology. 9: 904-12. PMID 24506227 DOI: 10.1021/Cb400875U |
0.773 |
|
| 2014 |
Velagapudi SP, Disney MD. Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor. Chemical Communications (Cambridge, England). 50: 3027-9. PMID 24503738 DOI: 10.1039/C3Cc00173C |
0.395 |
|
| 2014 |
Disney MD, Yildirim I, Childs-Disney JL. Methods to enable the design of bioactive small molecules targeting RNA. Organic & Biomolecular Chemistry. 12: 1029-39. PMID 24357181 DOI: 10.1039/C3Ob42023J |
0.817 |
|
| 2014 |
Childs-Disney JL, Yildirim I, Park H, Lohman JR, Guan L, Tran T, Sarkar P, Schatz GC, Disney MD. Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity. Acs Chemical Biology. 9: 538-50. PMID 24341895 DOI: 10.1021/Cb4007387 |
0.74 |
|
| 2013 |
Strack RL, Disney MD, Jaffrey SR. A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat-containing RNA. Nature Methods. 10: 1219-24. PMID 24162923 DOI: 10.1038/Nmeth.2701 |
0.576 |
|
| 2013 |
Rzuczek SG, Gao Y, Tang ZZ, Thornton CA, Kodadek T, Disney MD. Features of modularly assembled compounds that impart bioactivity against an RNA target. Acs Chemical Biology. 8: 2312-21. PMID 24032410 DOI: 10.1021/Cb400265Y |
0.633 |
|
| 2013 |
Disney MD. Rational design of chemical genetic probes of RNA function and lead therapeutics targeting repeating transcripts. Drug Discovery Today. 18: 1228-36. PMID 23939337 DOI: 10.1016/J.Drudis.2013.07.024 |
0.636 |
|
| 2013 |
Guan L, Disney MD. Covalent small-molecule-RNA complex formation enables cellular profiling of small-molecule-RNA interactions. Angewandte Chemie (International Ed. in English). 52: 10010-3. PMID 23913698 DOI: 10.1002/Anie.201301639 |
0.641 |
|
| 2013 |
Childs-Disney JL, Stepniak-Konieczna E, Tran T, Yildirim I, Park H, Chen CZ, Hoskins J, Southall N, Marugan JJ, Patnaik S, Zheng W, Austin CP, Schatz GC, Sobczak K, Thornton CA, ... Disney MD, et al. Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules. Nature Communications. 4: 2044. PMID 23806903 DOI: 10.1038/Ncomms3044 |
0.75 |
|
| 2013 |
Velagapudi SP, Disney MD. Defining RNA motif-aminoglycoside interactions via two-dimensional combinatorial screening and structure-activity relationships through sequencing. Bioorganic & Medicinal Chemistry. 21: 6132-8. PMID 23719281 DOI: 10.1016/J.Bmc.2013.04.072 |
0.651 |
|
| 2013 |
Sellier C, Freyermuth F, Tabet R, Tran T, He F, Ruffenach F, Alunni V, Moine H, Thibault C, Page A, Tassone F, Willemsen R, Disney MD, Hagerman PJ, Todd PK, et al. Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome. Cell Reports. 3: 869-80. PMID 23478018 DOI: 10.1016/J.Celrep.2013.02.004 |
0.509 |
|
| 2013 |
Yildirim I, Park H, Disney MD, Schatz GC. A dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations. Journal of the American Chemical Society. 135: 3528-38. PMID 23441937 DOI: 10.1021/Ja3108627 |
0.398 |
|
| 2013 |
Guan L, Disney MD. Small-molecule-mediated cleavage of RNA in living cells. Angewandte Chemie (International Ed. in English). 52: 1462-5. PMID 23280953 DOI: 10.1002/Anie.201206888 |
0.554 |
|
| 2012 |
Childs-Disney JL, Parkesh R, Nakamori M, Thornton CA, Disney MD. Rational design of bioactive, modularly assembled aminoglycosides targeting the RNA that causes myotonic dystrophy type 1. Acs Chemical Biology. 7: 1984-93. PMID 23130637 DOI: 10.1021/Cb3001606 |
0.774 |
|
| 2012 |
Tran T, Disney MD. Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations. Nature Communications. 3: 1125. PMID 23047683 DOI: 10.1038/Ncomms2119 |
0.648 |
|
| 2012 |
Velagapudi SP, Pushechnikov A, Labuda LP, French JM, Disney MD. Probing a 2-aminobenzimidazole library for binding to RNA internal loops via two-dimensional combinatorial screening. Acs Chemical Biology. 7: 1902-9. PMID 22958065 DOI: 10.1021/Cb300213G |
0.648 |
|
| 2012 |
Disney MD, Liu B, Yang WY, Sellier C, Tran T, Charlet-Berguerand N, Childs-Disney JL. A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome. Acs Chemical Biology. 7: 1711-8. PMID 22948243 DOI: 10.1021/Cb300135H |
0.772 |
|
| 2012 |
Childs-Disney JL, Hoskins J, Rzuczek SG, Thornton CA, Disney MD. Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive. Acs Chemical Biology. 7: 856-62. PMID 22332923 DOI: 10.1021/Cb200408A |
0.803 |
|
| 2012 |
Parkesh R, Childs-Disney JL, Nakamori M, Kumar A, Wang E, Wang T, Hoskins J, Tran T, Housman D, Thornton CA, Disney MD. Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching. Journal of the American Chemical Society. 134: 4731-42. PMID 22300544 DOI: 10.1021/Ja210088V |
0.814 |
|
| 2012 |
Kumar A, Parkesh R, Sznajder LJ, Childs-Disney JL, Sobczak K, Disney MD. Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts. Acs Chemical Biology. 7: 496-505. PMID 22252896 DOI: 10.1021/cb200413a |
0.783 |
|
| 2012 |
Guan L, Disney MD. Recent advances in developing small molecules targeting RNA. Acs Chemical Biology. 7: 73-86. PMID 22185671 DOI: 10.1021/Cb200447R |
0.641 |
|
| 2012 |
Disney MD. Studying modification of aminoglycoside antibiotics by resistance-causing enzymes via microarray. Methods in Molecular Biology (Clifton, N.J.). 808: 303-20. PMID 22057534 DOI: 10.1007/978-1-61779-373-8_21 |
0.321 |
|
| 2011 |
Kumar A, Park H, Fang P, Parkesh R, Guo M, Nettles KW, Disney MD. Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1 × 1 nucleotide UU internal loop conformations. Biochemistry. 50: 9928-35. PMID 21988728 DOI: 10.1021/Bi2013068 |
0.447 |
|
| 2011 |
Childs-Disney JL, Tsitovich PB, Disney MD. Using modularly assembled ligands to bind RNA internal loops separated by different distances. Chembiochem : a European Journal of Chemical Biology. 12: 2143-6. PMID 21830289 DOI: 10.1002/Cbic.201100298 |
0.799 |
|
| 2011 |
Kumar A, Fang P, Park H, Guo M, Nettles KW, Disney MD. A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome. Chembiochem : a European Journal of Chemical Biology. 12: 2140-2. PMID 21766409 DOI: 10.1002/Cbic.201100337 |
0.519 |
|
| 2011 |
Lee MM, French JM, Disney MD. Influencing uptake and localization of aminoglycoside-functionalized peptoids. Molecular Biosystems. 7: 2441-51. PMID 21611644 DOI: 10.1039/C1Mb05074E |
0.506 |
|
| 2011 |
Velagapudi SP, Seedhouse SJ, French J, Disney MD. Defining the RNA internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis. Journal of the American Chemical Society. 133: 10111-8. PMID 21604752 DOI: 10.1021/Ja200212B |
0.66 |
|
| 2011 |
Tran T, Disney MD. Molecular recognition of 6'-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches. Biochemistry. 50: 962-9. PMID 21207945 DOI: 10.1021/Bi101724H |
0.533 |
|
| 2010 |
Aminova O, Disney MD. A microarray-based method to perform nucleic acid selections. Methods in Molecular Biology (Clifton, N.J.). 669: 209-24. PMID 20857369 DOI: 10.1007/978-1-60761-845-4_17 |
0.489 |
|
| 2010 |
Tsitovich PB, Pushechnikov A, French JM, Disney MD. A chemoenzymatic route to diversify aminoglycosides enables a microarray-based method to probe acetyltransferase activity. Chembiochem : a European Journal of Chemical Biology. 11: 1656-60. PMID 20629012 DOI: 10.1002/Cbic.201000300 |
0.312 |
|
| 2010 |
Velagapudi SP, Seedhouse SJ, Disney MD. Structure-activity relationships through sequencing (StARTS) defines optimal and suboptimal RNA motif targets for small molecules. Angewandte Chemie (International Ed. in English). 49: 3816-8. PMID 20397174 DOI: 10.1002/Anie.200907257 |
0.62 |
|
| 2010 |
Tran T, Disney MD. Two-dimensional combinatorial screening of a bacterial rRNA A-site-like motif library: defining privileged asymmetric internal loops that bind aminoglycosides. Biochemistry. 49: 1833-42. PMID 20108982 DOI: 10.1021/Bi901998M |
0.583 |
|
| 2010 |
Seedhouse SJ, Labuda LP, Disney MD. The Privileged Chemical Space Predictor (PCSP): a computer program that identifies privileged chemical space from screens of modularly assembled chemical libraries. Bioorganic & Medicinal Chemistry Letters. 20: 1338-43. PMID 20097562 DOI: 10.1016/J.Bmcl.2010.01.017 |
0.423 |
|
| 2010 |
Disney MD, Lee MM, Pushechnikov A, Childs-Disney JL. The role of flexibility in the rational design of modularly assembled ligands targeting the RNAs that cause the myotonic dystrophies. Chembiochem : a European Journal of Chemical Biology. 11: 375-82. PMID 20058255 DOI: 10.1002/Cbic.200900716 |
0.797 |
|
| 2009 |
Lee MM, Childs-Disney JL, Pushechnikov A, French JM, Sobczak K, Thornton CA, Disney MD. Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophy. Journal of the American Chemical Society. 131: 17464-72. PMID 19904940 DOI: 10.1021/Ja906877Y |
0.798 |
|
| 2009 |
Paul DJ, Seedhouse SJ, Disney MD. Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside-RNA hairpin loop interactions. Nucleic Acids Research. 37: 5894-907. PMID 19726586 DOI: 10.1093/Nar/Gkp594 |
0.613 |
|
| 2009 |
Pushechnikov A, Lee MM, Childs-Disney JL, Sobczak K, French JM, Thornton CA, Disney MD. Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3. Journal of the American Chemical Society. 131: 9767-79. PMID 19552411 DOI: 10.1021/Ja9020149 |
0.791 |
|
| 2009 |
Lee MM, Pushechnikov A, Disney MD. Rational and modular design of potent ligands targeting the RNA that causes myotonic dystrophy 2. Acs Chemical Biology. 4: 345-55. PMID 19348464 DOI: 10.1021/Cb900025W |
0.626 |
|
| 2009 |
Labuda LP, Pushechnikov A, Disney MD. Small molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intron. Acs Chemical Biology. 4: 299-307. PMID 19278238 DOI: 10.1021/Cb800313M |
0.552 |
|
| 2008 |
Disney MD. Short-circuiting RNA splicing. Nature Chemical Biology. 4: 723-4. PMID 19008883 DOI: 10.1038/Nchembio1208-723 |
0.488 |
|
| 2008 |
Aminova O, Paul DJ, Childs-Disney JL, Disney MD. Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions. Biochemistry. 47: 12670-9. PMID 18991404 DOI: 10.1021/Bi8012615 |
0.757 |
|
| 2008 |
Disney MD, Labuda LP, Paul DJ, Poplawski SG, Pushechnikov A, Tran T, Velagapudi SP, Wu M, Childs-Disney JL. Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners. Journal of the American Chemical Society. 130: 11185-94. PMID 18652457 DOI: 10.1021/Ja803234T |
0.793 |
|
| 2008 |
Childs-Disney JL, Disney MD. A simple ligation-based method to increase the information density in sequencing reactions used to deconvolute nucleic acid selections. Rna (New York, N.Y.). 14: 390-4. PMID 18065718 DOI: 10.1261/Rna.576908 |
0.634 |
|
| 2007 |
Childs-Disney JL, Wu M, Pushechnikov A, Aminova O, Disney MD. A small molecule microarray platform to select RNA internal loop-ligand interactions. Acs Chemical Biology. 2: 745-54. PMID 17975888 DOI: 10.1021/Cb700174R |
0.8 |
|
| 2007 |
Disney MD, Childs-Disney JL. "Supra"molecular recognition of Galectin 1. Chemistry & Biology. 14: 1095-7. PMID 17961821 DOI: 10.1016/J.Chembiol.2007.10.002 |
0.638 |
|
| 2007 |
Disney MD, Barrett OJ. An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance. Biochemistry. 46: 11223-30. PMID 17867707 DOI: 10.1021/Bi701071H |
0.308 |
|
| 2007 |
Disney MD, Childs-Disney JL. Using selection to identify and chemical microarray to study the RNA internal loops recognized by 6'-N-acylated kanamycin A. Chembiochem : a European Journal of Chemical Biology. 8: 649-56. PMID 17394189 DOI: 10.1002/Cbic.200600569 |
0.807 |
|
| 2006 |
Barrett OJ, Childs JL, Disney MD. Chemical microarrays to identify ligands that bind pathogenic cells. Chembiochem : a European Journal of Chemical Biology. 7: 1882-5. PMID 17009274 DOI: 10.1002/Cbic.200600260 |
0.323 |
|
| 2006 |
Brun MA, Disney MD, Seeberger PH. Miniaturization of microwave-assisted carbohydrate functionalization to create oligosaccharide microarrays. Chembiochem : a European Journal of Chemical Biology. 7: 421-4. PMID 16444768 DOI: 10.1002/Cbic.200500361 |
0.457 |
|
| 2006 |
Kehr JC, Zilliges Y, Springer A, Disney MD, Ratner DD, Bouchier C, Seeberger PH, de Marsac NT, Dittmann E. A mannan binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa. Molecular Microbiology. 59: 893-906. PMID 16420359 DOI: 10.1111/J.1365-2958.2005.05001.X |
0.466 |
|
| 2005 |
Disney MD, Hook DF, Namoto K, Seeberger PH, Seebach D. N-linked glycosylated beta-peptides are resistant to degradation by glycoamidase A. Chemistry & Biodiversity. 2: 1624-34. PMID 17191959 DOI: 10.1002/Cbdv.200590132 |
0.384 |
|
| 2005 |
Disney MD, Stephenson R, Wright TW, Haidaris CG, Turner DH, Gigliotti F. Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis. Antimicrobial Agents and Chemotherapy. 49: 1326-30. PMID 15793106 DOI: 10.1128/Aac.49.4.1326-1330.2005 |
0.34 |
|
| 2004 |
Disney MD, Seeberger PH. The use of carbohydrate microarrays to study carbohydrate-cell interactions and to detect pathogens. Chemistry & Biology. 11: 1701-7. PMID 15610854 DOI: 10.1016/J.Chembiol.2004.10.011 |
0.497 |
|
| 2004 |
Disney MD, Childs JL, Turner DH. Hoechst 33258 selectively inhibits group I intron self-splicing by affecting RNA folding. Chembiochem : a European Journal of Chemical Biology. 5: 1647-52. PMID 15532034 DOI: 10.1002/Cbic.200400159 |
0.593 |
|
| 2004 |
Disney MD, Zheng J, Swager TM, Seeberger PH. Detection of bacteria with carbohydrate-functionalized fluorescent polymers. Journal of the American Chemical Society. 126: 13343-6. PMID 15479090 DOI: 10.1021/Ja047936I |
0.405 |
|
| 2004 |
Ratner DM, Adams EW, Disney MD, Seeberger PH. Tools for glycomics: mapping interactions of carbohydrates in biological systems. Chembiochem : a European Journal of Chemical Biology. 5: 1375-83. PMID 15457538 DOI: 10.1002/Cbic.200400106 |
0.438 |
|
| 2004 |
Disney MD, Seeberger PH. Aminoglycoside microarrays to explore interactions of antibiotics with RNAs and proteins. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 3308-14. PMID 15224340 DOI: 10.1002/Chem.200306017 |
0.72 |
|
| 2004 |
Mathews DH, Disney MD, Childs JL, Schroeder SJ, Zuker M, Turner DH. Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure. Proceedings of the National Academy of Sciences of the United States of America. 101: 7287-92. PMID 15123812 DOI: 10.1073/Pnas.0401799101 |
0.608 |
|
| 2004 |
Disney MD, Magnet S, Blanchard JS, Seeberger PH. Aminoglycoside microarrays to study antibiotic resistance. Angewandte Chemie (International Ed. in English). 43: 1591-4. PMID 15022242 DOI: 10.1002/Anie.200353236 |
0.379 |
|
| 2004 |
Disney MD, Childs JL, Turner DH. New approaches to targeting RNA with oligonucleotides: inhibition of group I intron self-splicing. Biopolymers. 73: 151-61. PMID 14691946 DOI: 10.1002/Bip.10520 |
0.628 |
|
| 2004 |
Disney MD, Seeberger PH. Carbohydrate arrays as tools for the glycomics revolution Drug Discovery Today: Targets. 3: 151-158. DOI: 10.1016/S1741-8372(04)02443-0 |
0.42 |
|
| 2004 |
Ratner DM, Adams EW, Disney MD, Seeberger PH. Cover Picture: Tools for Glycomics: Mapping Interactions of Carbohydrates in Biological Systems (ChemBioChem 10/2004) Chembiochem. 5: 1308-1308. DOI: 10.1002/Cbic.200490038 |
0.402 |
|
| 2004 |
Disney MD, Magnet S, Blanchard JS, Seeberger PH. Aminoglycosid-Mikroarrays für Bindungsstudien an Resistenzproteinen Angewandte Chemie. 116: 1618-1620. DOI: 10.1002/Ange.200353236 |
0.446 |
|
| 2003 |
Disney MD, Haidaris CG, Turner DH. Uptake and antifungal activity of oligonucleotides in Candida albicans. Proceedings of the National Academy of Sciences of the United States of America. 100: 1530-4. PMID 12552085 DOI: 10.1073/Pnas.0337462100 |
0.436 |
|
| 2002 |
Childs JL, Disney MD, Turner DH. Oligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicing. Proceedings of the National Academy of Sciences of the United States of America. 99: 11091-6. PMID 12169671 DOI: 10.1073/Pnas.172391199 |
0.555 |
|
| 2001 |
Disney MD, Matray T, Gryaznov SM, Turner DH. Binding enhancement by tertiary interactions and suicide inhibition of a Candida albicans group I intron by phosphoramidate and 2'-O-methyl hexanucleotides. Biochemistry. 40: 6520-6. PMID 11371215 DOI: 10.1021/bi002009j |
0.479 |
|
| 2001 |
Disney MD, Haidaris CG, Turner DH. Recognition elements for 5' exon substrate binding to the Candida albicans group I intron. Biochemistry. 40: 6507-19. PMID 11371214 DOI: 10.1021/Bi002008R |
0.374 |
|
| 2000 |
Disney MD, Gryaznov SM, Turner DH. Contributions of individual nucleotides to tertiary binding of substrate by a Pneumocystis carinii group I intron. Biochemistry. 39: 14269-78. PMID 11087376 DOI: 10.1021/Bi001345X |
0.424 |
|
| 2000 |
Disney MD, Testa SM, Turner DH. Targeting a Pneumocystis carinii group I intron with methylphosphonate oligonucleotides: backbone charge is not required for binding or reactivity. Biochemistry. 39: 6991-7000. PMID 10841781 DOI: 10.1021/Bi992937M |
0.713 |
|
| 1999 |
Testa SM, Disney MD, Turner DH, Kierzek R. Thermodynamics of RNA-RNA duplexes with 2- or 4-thiouridines: implications for antisense design and targeting a group I intron. Biochemistry. 38: 16655-62. PMID 10600128 DOI: 10.1021/Bi991187D |
0.726 |
|
| Show low-probability matches. |
