John W. Schrader - Publications

Affiliations: 
University of British Columbia, Vancouver, Vancouver, BC, Canada 

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Dhagat U, Hercus TR, Broughton SE, Nero TL, Cheung Tung Shing KS, Barry EF, Thomson CA, Bryson S, Pai EF, McClure BJ, Schrader JW, Lopez AF, Parker MW. The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities. Mabs. PMID 29969365 DOI: 10.1080/19420862.2018.1494107  0.336
2017 Schrader JW, McLean GR. Multispecificity of a recombinant anti-ras monoclonal antibody. Journal of Molecular Recognition : Jmr. PMID 29115701 DOI: 10.1002/Jmr.2683  0.363
2016 Bryson S, Thomson CA, Risnes LF, Dasgupta S, Smith K, Schrader JW, Pai EF. Structures of Preferred Human IgV Genes-Based Protective Antibodies Identify How Conserved Residues Contact Diverse Antigens and Assign Source of Specificity to CDR3 Loop Variation. Journal of Immunology (Baltimore, Md. : 1950). PMID 27183571 DOI: 10.4049/Jimmunol.1402890  0.478
2015 Ehrhardt A, Wang B, Yung AC, Wang Y, Kozlowski P, van Breemen C, Schrader JW. Urinary Retention, Incontinence, and Dysregulation of Muscarinic Receptors in Male Mice Lacking Mras. Plos One. 10: e0141493. PMID 26516777 DOI: 10.1371/Journal.Pone.0141493  0.537
2015 Ehrhardt A, Wang B, Leung MJ, Schrader JW. Absence of M-Ras modulates social behavior in mice. Bmc Neuroscience. 16: 68. PMID 26490652 DOI: 10.1186/S12868-015-0209-8  0.514
2013 Wang Y, Thomson CA, Allan LL, Jackson LM, Olson M, Hercus TR, Nero TL, Turner A, Parker MW, Lopez AL, Waddell TK, Anderson GP, Hamilton JA, Schrader JW. Characterization of pathogenic human monoclonal autoantibodies against GM-CSF. Proceedings of the National Academy of Sciences of the United States of America. 110: 7832-7. PMID 23620516 DOI: 10.1073/Pnas.1216011110  0.32
2012 Thomson CA, Olson M, Jackson LM, Schrader JW. A simplified method for the efficient refolding and purification of recombinant human GM-CSF. Plos One. 7: e49891. PMID 23166789 DOI: 10.1371/Journal.Pone.0049891  0.307
2009 Lorén CE, Schrader JW, Ahlgren U, Gunhaga L. FGF signals induce Caprin2 expression in the vertebrate lens Differentiation. 77: 386-394. PMID 19275872 DOI: 10.1016/J.Diff.2008.11.003  0.321
2007 Solomon S, Xu Y, Wang B, David MD, Schubert P, Kennedy D, Schrader JW. Distinct structural features of Caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2α, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs Molecular and Cellular Biology. 27: 2324-2342. PMID 17210633 DOI: 10.1128/Mcb.02300-06  0.322
2006 Guo X, Stratton L, Schrader JW. Expression of activated M-Ras in hemopoietic stem cells initiates leukemogenic transformation, immortalization and preferential generation of mast cells Oncogene. 25: 4241-4244. PMID 16501601 DOI: 10.1038/Sj.Onc.1209452  0.388
2005 David MD, Cochrane CL, Duncan SK, Schrader JW. Pure lipopolysaccharide or synthetic lipid A induces activation of p21Ras in primary macrophages through a pathway dependent on Src family kinases and PI3K Journal of Immunology. 175: 8236-8241. PMID 16339563 DOI: 10.4049/Jimmunol.175.12.8236  0.322
2005 Wang B, David MD, Schrader JW. Absence of caprin-1 results in defects in cellular proliferation Journal of Immunology. 175: 4274-4282. PMID 16177067 DOI: 10.4049/Jimmunol.175.7.4274  0.349
2005 Guo X, Schrader KA, Xu Y, Schrader JW. Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras Oncogene. 24: 2330-2342. PMID 15735740 DOI: 10.1038/Sj.Onc.1208441  0.426
2004 Ehrhardt A, David MD, Ehrhardt GRA, Schrader JW. Distinct mechanisms determine the patterns of differential activation of H-Ras, N-Ras, K-Ras 4B, and M-Ras by receptors for growth factors or antigen Molecular and Cellular Biology. 24: 6311-6323. PMID 15226433 DOI: 10.1128/Mcb.24.14.6311-6323.2004  0.599
2004 Zhang KX, Ward KR, Schrader JW. Multiple aspects of the phenotype of mammary epithelial cells transformed by expression of activated M-Ras depend on an autocrine mechanism mediated by hepatocyte growth factor/scatter factor Molecular Cancer Research. 2: 242-255. PMID 15140946  0.316
2004 Ward KR, Zhang KX, Somasiri AM, Roskelley CD, Schrader JW. Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis Oncogene. 23: 1187-1196. PMID 14961075 DOI: 10.1038/Sj.Onc.1207226  0.4
2004 Grill B, Wilson GM, Zhang KX, Wang B, Doyonnas R, Quadroni M, Schrader JW. Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins. Journal of Immunology (Baltimore, Md. : 1950). 172: 2389-400. PMID 14764709 DOI: 10.4049/Jimmunol.172.4.2389  0.638
2003 Schrader JW. Interleukin is as interleukin does Journal of Immunological Methods. 276: 1-3. PMID 12774788 DOI: 10.1016/S0022-1759(03)00058-9  0.363
2003 Guo X, Gerl RE, Schrader JW. Defining the involvement of p38α MAPK in the production of anti- and proinflammatory cytokines using an SB 203580-resistant form of the kinase Journal of Biological Chemistry. 278: 22237-22242. PMID 12637577 DOI: 10.1074/Jbc.M300847200  0.732
2002 Schrader JW. Interleukin is as interleukin does. Trends in Immunology. 23: 573-4. PMID 12464567 DOI: 10.1016/S1471-4906(02)02336-0  0.363
2002 Grill B, Schrader JW. Activation of Rac-1, Rac-2, and Cdc42 by hemopoietic growth factors or cross-linking of the B-lymphocyte receptor for antigen. Blood. 100: 3183-92. PMID 12384416 DOI: 10.1182/Blood-2002-01-0154  0.687
2002 Ehrhardt A, Ehrhardt GRA, Guo X, Schrader JW. Ras and relatives - Job sharing and networking keep an old family together Experimental Hematology. 30: 1089-1106. PMID 12384139 DOI: 10.1016/S0301-472X(02)00904-9  0.6
2002 Schrader JW, Schallhorn A, Grill B, Guo X. Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells. Molecular Immunology. 38: 1181-6. PMID 12217381 DOI: 10.1016/S0161-5890(02)00060-3  0.664
2001 Salmon RA, Guo X, Teh HS, Schrader JW. The p38 mitogen-activated protein kinases can have opposing roles in the antigen-dependent or endotoxin-stimulated production of IL-12 and IFN-γ European Journal of Immunology. 31: 3218-3227. PMID 11745338 DOI: 10.1002/1521-4141(200111)31:11<3218::Aid-Immu3218>3.0.Co;2-9  0.411
2001 Ehrhardt GRA, Korherr C, Wieler JS, Knaus M, Schrader JW. A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth Oncogene. 20: 188-197. PMID 11313946 DOI: 10.1038/Sj.Onc.1204053  0.388
2000 Lee YB, Schrader JW, Kim SU. p38 map kinase regulates TNF-α production in human astrocytes and microglia by multiple mechanisms Cytokine. 12: 874-880. PMID 10880231 DOI: 10.1006/Cyto.2000.0688  0.323
2000 Ohba Y, Mochizuki N, Yamashita S, Chan AM, Schrader JW, Hattori S, Nagashima K, Matsuda M. Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3. The Journal of Biological Chemistry. 275: 20020-6. PMID 10777492 DOI: 10.1074/Jbc.M000981200  0.349
2000 Schrader J, Korherr C, Ehrhardt G. A novel effector of m-ras and oncogenic, leukomegic member of the ras superfamily Experimental Hematology. 28: 54. DOI: 10.1016/S0301-472X(00)00258-7  0.74
1999 Ehrhardt GRA, Leslie KB, Lee F, Wieler JS, Schrader JW. M-Ras, a widely expressed 29-kD homologue of p21 Ras: Expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line Blood. 94: 2433-2444. PMID 10498616 DOI: 10.1182/Blood.V94.7.2433.419K31_2433_2444  0.424
1999 Orban PC, Levings MK, Schrader JW. Heterodimerization of the α and β chains of the interleukin-3 (IL-3) receptor is necessary and sufficient for IL-3-induced mitogenesis Blood. 94: 1614-1622. PMID 10477686 DOI: 10.1182/Blood.V94.5.1614.417K22_1614_1622  0.363
1999 Orchansky PL, Kwan R, Lee F, Schrader JW. Characterization of the cytoplasmic domain of interleukin-13 receptor- α Journal of Biological Chemistry. 274: 20818-20825. PMID 10409622 DOI: 10.1074/Jbc.274.30.20818  0.393
1999 Levings MK, Bessette DC, Schrader JW. Interleukin-4 synergizes with Raf-1 to promote long-term proliferation and activation of c-jun N-terminal kinase Blood. 93: 3694-3702. PMID 10339476 DOI: 10.1182/Blood.V93.11.3694.411A33_3694_3702  0.484
1999 Scheid MP, Foltz IN, Young PR, Schrader JW, Duronio V. Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival Blood. 93: 217-225. PMID 9864164 DOI: 10.1182/Blood.V93.1.217.401K16_217_225  0.42
1998 Foltz IN, Gerl RE, Wieler JS, Luckach M, Salmon RA, Schrader JW. Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli Journal of Biological Chemistry. 273: 9344-9351. PMID 9535930 DOI: 10.1074/Jbc.273.15.9344  0.737
1997 Bone H, Dechert U, Jirik F, Schrader JW, Welham MJ. SHP1 and SHP2 protein-tyrosine phosphatases associate with βc after interleukin-3-induced receptor tyrosine phosphorylation: Identification of potential binding sites and substrates Journal of Biological Chemistry. 272: 14470-14476. PMID 9162089 DOI: 10.1074/Jbc.272.22.14470  0.408
1997 Foltz IN, Schrader JW. Activation of the stress-activated protein kinases by multiple hematopoietic growth factors with the exception of interleukin-4 Blood. 89: 3092-3096. PMID 9129010 DOI: 10.1182/Blood.V89.9.3092  0.433
1997 Foltz IN, Lee JC, Young PR, Schrader JW. Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway Journal of Biological Chemistry. 272: 3296-3301. PMID 9013568 DOI: 10.1074/Jbc.272.6.3296  0.352
1997 Welham MJ, Bone H, Levings M, Learmonth L, Wang LM, Leslie KB, Pierce JH, Schrader JW. Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells Journal of Biological Chemistry. 272: 1377-1381. PMID 8995447 DOI: 10.1074/Jbc.272.2.1377  0.396
1997 McLean GR, Quadros EV, Rothenberg SP, Morgan AC, Schrader JW, Ziltener HJ. Antibodies to transcobalamin II block in vitro proliferation of leukemic cells. Blood. 89: 235-42. PMID 8978297 DOI: 10.1182/Blood.V89.1.235  0.355
1996 Leslie KB, Jalbert S, Orban P, Welham M, Duronio V, Schrader JW. Genetic basis of hypo-responsiveness of A/J mice to interleukin-3 Blood. 87: 3186-3194. PMID 8605333 DOI: 10.1182/Blood.V87.8.3186.Bloodjournal8783186  0.392
1996 Watari K, Mayani H, Lee F, Dragowska W, Lansdorp PM, Schrader JW. Production of interleukin 1β by human hematopoietic progenitor cells Journal of Clinical Investigation. 97: 1666-1674. PMID 8601632 DOI: 10.1172/Jci118593  0.37
1995 Welham MJ, Learmonth L, Bone H, Schrader JW. Interleukin-13 signal transduction in lymphohemopoietic cells: Similarities and differences in signal transduction with interleukin-4 and insulin Journal of Biological Chemistry. 270: 12286-12296. PMID 7744881 DOI: 10.1074/Jbc.270.20.12286  0.43
1994 Welham MJ, Duronio V, Schrader JW. Interleukin-4-dependent Proliferation Dissociates p44erk-1, p42erk-2, and p21ras Activation from Cell Growth Journal of Biological Chemistry. 269: 5865-5873. PMID 8119929  0.373
1994 Welham MJ, Duronio V, Leslie KB, Bowtell D, Schrader JW. Multiple hemopoietins, with the exception of interleukin-4, induce modification of Shc and mSos1, but not their translocation Journal of Biological Chemistry. 269: 21165-21176. PMID 8063737  0.328
1994 Welham MJ, Dechert U, Leslie KB, Jirik F, Schrader JW. Interleukin (IL)-3 and Granulocyte/Macrophage Colony-stimulating Factor, but Not IL-4, Induce Tyrosine Phosphorylation, Activation, and Association of SHPTP2 with Grb2 and Phosphatidylinositol 3′-Kinase Journal of Biological Chemistry. 269: 23764-23768. PMID 7522233  0.345
1994 Gold MR, Duronio V, Saxena SP, Schrader JW, Aebersold R. Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells: Association of the enzyme with various tyrosine-phosphorylated proteins Journal of Biological Chemistry. 269: 5403-5412. PMID 7508938  0.335
1994 Watari K, Lansdorp P, Dragowska W, Mayani H, Schrader J. Expression of interleukin-1 beta gene in candidate human hematopoietic stem cells Blood. 84: 36-43. DOI: 10.1182/Blood.V84.1.36.36  0.366
1994 Welham M, Dechert U, Leslie K, Jirik F, Schrader J. IL-3 and GM-CSF induce tyrosine phosphorylation of the protein tyrosine phosphatase, SH-PTP2, leading to its activation and association with GRB2 and PI3′-kinase Cytokine. 6: 579. DOI: 10.1016/1043-4666(94)90317-4  0.403
1994 Schrader J, Welham M, Abraham S, Leslie K, Orban P, Weiler J, Dechert U, Jirik F. Similarities and differences in signals transduced by IL-3/GM-CSF, IL-4/IL-13, and CD40 ligand Cytokine. 6: 579. DOI: 10.1016/1043-4666(94)90315-8  0.346
1994 Abraham S, Schrader JW. Intracellular antibody expression for the attenuation of p21ras in hemopoietic cells Cytokine. 6: 577. DOI: 10.1016/1043-4666(94)90306-9  0.316
1993 Watts JD, Welham MJ, Kalt L, Schrader JW, Aebersold R. IL-2 stimulation of T lymphocytes induces sequential activation of mitogen-activated protein kinases and phosphorylation of p56lck at serine-59 Journal of Immunology. 151: 6862-6871. PMID 8258696  0.36
1993 Ziltener HJ, Maines-Bandiera S, Schrader JW, Auersperg N. Secretion of bioactive interleukin-1, interleukin-6, and colony- stimulating factors by human ovarian surface epithelium Biology of Reproduction. 49: 635-641. PMID 7691194 DOI: 10.1095/Biolreprod49.3.635  0.393
1992 Duronio V, Clark-Lewis I, Federsppiel B, Wieler JS, Schrader JW. Tyrosine phosphorylation of receptor β subunits and common substrates in response to interleukin-3 and granulocyte-macrophage colony-stimulating factor Journal of Biological Chemistry. 267: 21856-21863. PMID 1400495  0.308
1992 Welham MJ, Duronio V, Sanghera JS, Pelech SL, Schrader JW. Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members Journal of Immunology. 149: 1683-1693. PMID 1380536  0.332
1992 Duronio V, Welham MJ, Abraham S, Dryden P, Schrader JW. P21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein Proceedings of the National Academy of Sciences of the United States of America. 89: 1587-1591. PMID 1371879 DOI: 10.1073/Pnas.89.5.1587  0.432
1991 Schrader JW. Peptide regulatory factors and optimization of vaccines Molecular Immunology. 28: 295-299. PMID 2017199 DOI: 10.1016/0161-5890(91)90077-W  0.403
1991 Leslie KB, Lee F, Schrader JW. Intracisternal A-type particle-mediated activations of cytokine genes in a murine myelomonocytic leukemia: Generation of functional cytokine mRNAs by retroviral splicing events Molecular and Cellular Biology. 11: 5562-5570. PMID 1922064 DOI: 10.1128/Mcb.11.11.5562  0.392
1991 Leslie KB, Ziltener HJ, Schrader JW. The role of interleukin-1 and granulocyte-macrophage colony-stimulating factor in the paracrine stimulation of an in vivo-derived murine myeloid leukemia Blood. 78: 1301-1310. PMID 1878593 DOI: 10.1182/Blood.V78.5.1301.1301  0.428
1991 Duronio V, Granleese SR, Clark-Lewis I, Schrader JW, Ziltener HJ. Antibodies to interleukin 3 as probes for the interaction of interleukin 3 with its receptor Cytokine. 3: 414-420. PMID 1751778 DOI: 10.1016/1043-4666(91)90045-F  0.375
1991 Welham MJ, Schrader JW. Modulation of c-kit mRNA and Protein by Hemopoietic Growth Factors Molecular and Cellular Biology. 11: 2901-2904. PMID 1708097 DOI: 10.1128/Mcb.11.5.2901  0.401
1986 Schrader JW, Ziltener HJ, Leslie KB. Structural homologies among the hemopoietins. Proceedings of the National Academy of Sciences of the United States of America. 83: 2458-62. PMID 3085095 DOI: 10.1073/Pnas.83.8.2458  0.343
1986 Clark-Lewis I, Aebersold R, Ziltener H, Schrader JW, Hood LE, Kent SB. Automated chemical synthesis of a protein growth factor for hemopoietic cells, interleukin-3. Science (New York, N.Y.). 231: 134-9. PMID 3079915 DOI: 10.1126/Science.3079915  0.39
1985 Wong GH, Bartlett PF, Clark-Lewis I, McKimm-Breschkin JL, Schrader JW. Interferon-gamma induces the expression of H-2 and Ia antigens on brain cells. Journal of Neuroimmunology. 7: 255-78. PMID 3919057 DOI: 10.1016/S0165-5728(84)80026-0  0.517
1985 Crapper RM, Vairo G, Hamilton JA, Clark-Lewis I, Schrader JW. Stimulation of bone marrow-derived and peritoneal macrophages by a T lymphocyte-derived hemopoietic growth factor, persisting cell-stimulating factor. Blood. 66: 859-65. PMID 3899216 DOI: 10.1182/Blood.V66.4.859.Bloodjournal664859  0.335
1985 Crapper RM, Schrader JW. Antibody stimulation of hemopoietic progenitor cells. Blood. 65: 869-76. PMID 3872141 DOI: 10.1182/Blood.V65.4.869.869  0.364
1984 Wong GH, Bartlett PF, Clark-Lewis I, Battye F, Schrader JW. Inducible expression of H-2 and Ia antigens on brain cells. Nature. 310: 688-91. PMID 6433204 DOI: 10.1038/310688A0  0.475
1983 Schrader JW, Crapper RM. Autogenous production of a hemopoietic growth factor, persisting-cell-stimulating factor, as a mechanism for transformation of bone marrow-derived cells Proceedings of the National Academy of Sciences of the United States of America. 80: 6892-6896. PMID 6417657 DOI: 10.1073/Pnas.80.22.6892  0.347
1983 Ihle JN, Keller J, Oroszlan S, Henderson LE, Copeland TD, Fitch F, Prystowsky MB, Goldwasser E, Schrader JW, Palaszynski E, Dy M, Lebel B. Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, p cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity. Journal of Immunology (Baltimore, Md. : 1950). 131: 282-7. PMID 6190911  0.341
1982 Wong GHW, Clark Lewis I, McKimm Breschkin JL, Schrader JW. Interferon-γ-like molecule induces Ia antigens on cultured mast cell progenitors Proceedings of the National Academy of Sciences of the United States of America. 79: 6989-6993. PMID 6184720 DOI: 10.1073/Pnas.79.22.6989  0.375
1982 Schrader JW, Battye F, Scollay R. Expression of Thy-1 antigen is not limited to T cells in cultures of mouse hemopoietic cells Proceedings of the National Academy of Sciences of the United States of America. 79: 4161-4165. PMID 6125942 DOI: 10.1073/Pnas.79.13.4161  0.343
1981 Schrader JW, Bartlett PF, Clark-Lewis I, Boyd AW. Lymphoid differentiation in vitro. Ciba Foundation Symposium. 84: 130-60. PMID 7023867  0.432
1981 Burgess AW, Bartlett PF, Metcalf D, Nicola NA, Clark-Lewis I, Schrader JW. Granulocyte-macrophage colony-stimulating factor produced by an inducible murine T-cell hybridoma: molecular properties and cellular specificity. Experimental Hematology. 9: 893-903. PMID 6978261  0.49
1976 Schrader JW, Edelman GM. Participation of the H 2 antigens of tumor cells in their lysis by syngeneic T cells Journal of Experimental Medicine. 143: 601-614. PMID 1082492 DOI: 10.1084/Jem.143.3.601  0.301
1975 Schrader JW, Cunningham BA, Edelman GM. Functional interactions of viral and histocompatibility antigens at tumor cell surfaces Proceedings of the National Academy of Sciences of the United States of America. 72: 5066-5070. PMID 1108012 DOI: 10.1073/Pnas.72.12.5066  0.301
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