Raghu R. Chivukula, M.D, Ph.D.
Affiliations: | 2013 | Human Genetics | Johns Hopkins University, Baltimore, MD |
| 2013- | Massachusetts General Hospital / Harvard Medical School | ||
| 2018- | Whitehead Institute, Cambridge, MA, United States |
Area:
Genetics, Molecular BiologyGoogle:
"Raghu Chivukula"Parents
Sign in to add mentor| Joshua Mendell | grad student | 2007-2013 | Johns Hopkins | |
| (Novel in vivo roles for mammalian microRNAs in hepatic and intestinal pathophysiology.) | ||||
| David M. Sabatini | post-doc | 2018- | Whitehead Institute (Chemistry Tree) | |
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Publications
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| Valenstein ML, Lalgudi PV, Kedir JF, et al. (2025) Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation. Nature. 637: E11-E14 |
| Valenstein ML, Lalgudi PV, Gu X, et al. (2024) Rag-Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway. Proceedings of the National Academy of Sciences of the United States of America. 121: e2322755121 |
| Shi CY, Elcavage LE, Chivukula RR, et al. (2023) ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development. Genome Research |
| Chivukula RR, Montoro DT, Leung HM, et al. (2020) Author Correction: A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Nature Medicine |
| Chivukula RR, Montoro DT, Leung HM, et al. (2020) A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Nature Medicine |
| Knabel MK, Ramachandran K, Karhadkar S, et al. (2015) Systemic Delivery of scAAV8-Encoded MiR-29a Ameliorates Hepatic Fibrosis in Carbon Tetrachloride-Treated Mice. Plos One. 10: e0124411 |
| Zeitels LR, Acharya A, Shi G, et al. (2014) Tumor suppression by miR-26 overrides potential oncogenic activity in intestinal tumorigenesis. Genes & Development. 28: 2585-90 |
| Chivukula RR, Shi G, Acharya A, et al. (2014) An essential mesenchymal function for miR-143/145 in intestinal epithelial regeneration. Cell. 157: 1104-16 |
| Hsu SH, Wang B, Kota J, et al. (2012) Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. The Journal of Clinical Investigation. 122: 2871-83 |
| Pramanik D, Campbell NR, Karikari C, et al. (2011) Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice. Molecular Cancer Therapeutics. 10: 1470-80 |