Merlin N. Gnanapragasam, Ph.D.

Affiliations: 
2010 Human Genetics Virginia Commonwealth University, Richmond, VA, United States 
Area:
Molecular Biology, Genetics
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"Merlin Gnanapragasam"

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Gordon D. Ginder grad student 2010 VCU
 (The Role of Methyl CpG Binding Domain Protein 2 (MBD2) in the Regulation of Embryonic and Fetal beta-type Globin Genes.)
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Publications

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Liang R, Campreciós G, Kou Y, et al. (2015) A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis. Plos Genetics. 11: e1005526
Yien YY, Gnanapragasam MN, Gupta R, et al. (2015) Alternative splicing of EKLF/KLF1 in murine primary erythroid tissues. Experimental Hematology. 43: 65-70
Xue L, Galdass M, Gnanapragasam MN, et al. (2014) Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche. Development (Cambridge, England). 141: 2245-54
Jaffray JA, Mitchell WB, Gnanapragasam MN, et al. (2013) Erythroid transcription factor EKLF/KLF1 mutation causing congenital dyserythropoietic anemia type IV in a patient of Taiwanese origin: review of all reported cases and development of a clinical diagnostic paradigm. Blood Cells, Molecules & Diseases. 51: 71-5
Amaya M, Desai M, Gnanapragasam MN, et al. (2013) Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells. Blood. 121: 3493-501
Mian OY, Wang SZ, Zhu SZ, et al. (2011) Methyl-binding domain protein 2-dependent proliferation and survival of breast cancer cells. Molecular Cancer Research : McR. 9: 1152-62
Gnanapragasam MN, Scarsdale JN, Amaya ML, et al. (2011) p66Alpha-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex. Proceedings of the National Academy of Sciences of the United States of America. 108: 7487-92
Rupon JW, Wang SZ, Gnanapragasam M, et al. (2011) MBD2 contributes to developmental silencing of the human ε-globin gene. Blood Cells, Molecules & Diseases. 46: 212-9
Ginder GD, Gnanapragasam MN, Mian OY. (2008) The role of the epigenetic signal, DNA methylation, in gene regulation during erythroid development. Current Topics in Developmental Biology. 82: 85-116
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