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Xiaowei Lu

Affiliations: 
Cell Biology University of Virginia School of Medicine, Charlottesville, VA, United States 
Area:
Developmental regulation of planar cell polarity in the mammalian nervous system
Website:
https://med.virginia.edu/faculty/faculty-listing/xl6f/
Google:
"Xiaowei Lu"
Bio:

Lu, Xiaowei Molecular analyses of the class B synthetic multivulva genes of Caenorhabditis elegans Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.

Cross-listing: Cell Biology Tree

Parents

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H. Robert Horvitz grad student 1999 MIT
 (Molecular analyses of the class B synthetic multivulva genes of Caenorhabditis elegans.)

Children

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Conor Wythe Sipe grad student 2013 UVA
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Publications

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Xu B, Washington AM, Domeniconi RF, et al. (2016) Protein tyrosine kinase 7 is essential for tubular morphogenesis of the Wolffian duct. Developmental Biology. 412: 219-33
Lu X, Sipe CW. (2016) Developmental regulation of planar cell polarity and hair-bundle morphogenesis in auditory hair cells: lessons from human and mouse genetics. Wiley Interdisciplinary Reviews. Developmental Biology. 5: 85-101
Williams M, Yen W, Lu X, et al. (2014) Distinct apical and basolateral mechanisms drive planar cell polarity-dependent convergent extension of the mouse neural plate. Developmental Cell. 29: 34-46
Andreeva A, Lee J, Lohia M, et al. (2014) PTK7-Src signaling at epithelial cell contacts mediates spatial organization of actomyosin and planar cell polarity. Developmental Cell. 29: 20-33
Sipe CW, Liu L, Lee J, et al. (2013) Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization. Development (Cambridge, England). 140: 1785-95
Lee J, Andreeva A, Sipe CW, et al. (2012) PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium. Current Biology : Cb. 22: 956-66
Grimsley-Myers CM, Sipe CW, Wu DK, et al. (2012) Redundant functions of Rac GTPases in inner ear morphogenesis. Developmental Biology. 362: 172-86
Sipe CW, Lu X. (2011) Kif3a regulates planar polarization of auditory hair cells through both ciliary and non-ciliary mechanisms. Development (Cambridge, England). 138: 3441-9
Paudyal A, Damrau C, Patterson VL, et al. (2010) The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. Bmc Developmental Biology. 10: 87
Grimsley-Myers CM, Sipe CW, Géléoc GS, et al. (2009) The small GTPase Rac1 regulates auditory hair cell morphogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15859-69
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