Yuet Wai Kan, M.D.
Affiliations: | Departments of Medicine and Laboratory Medicine | University of California, San Francisco, San Francisco, CA |
Area:
HematologyGoogle:
"Yuet Wai Kan"Bio:
Kan was the first to establish that a single DNA mutation could lead to a human disease, and the first to diagnose a human disease by using DNA.
Children
Sign in to add trainee| Barry Douglas Bruce | research assistant | 1982-1990 | University of California at San Francisco Medical Center (Cell Biology Tree) |
| Depei Liu | grad student | PUMC |
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Publications
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| Feng D, Kan YW. (2005) The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of beta-like globin genes. Proceedings of the National Academy of Sciences of the United States of America. 102: 9896-900 |
| Chang JC, Lu R, Lin C, et al. (1998) Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb betas-globin yeast artificial chromosome: A mouse model of sickle cell anemia. Proceedings of the National Academy of Sciences of the United States of America. 95: 14886-90 |
| Gaensler KM, Kitamura M, Kan YW. (1993) Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 90: 11381-5 |
| Liu D, Chang JC, Moi P, et al. (1992) Dissection of the enhancer activity of beta-globin 5' DNase I-hypersensitive site 2 in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 89: 3899-903 |
| Chang JC, Liu D, Kan YW. (1992) A 36-base-pair core sequence of locus control region enhances retrovirally transferred human beta-globin gene expression. Proceedings of the National Academy of Sciences of the United States of America. 89: 3107-10 |
| Curtin PT, Liu DP, Liu W, et al. (1989) Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site. Proceedings of the National Academy of Sciences of the United States of America. 86: 7082-6 |