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Remy L. Brim, Ph.D. - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
behavioral pharmacology
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8 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Collins GT, Brim RL, Noon KR, Narasimhan D, Lukacs NW, Sunahara RK, Woods JH, Ko MC. Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 342: 205-13. PMID 22518021 DOI: 10.1124/Jpet.112.194639  0.788
2012 Brim RL, Noon KR, Collins GT, Stein A, Nichols J, Narasimhan D, Ko MC, Woods JH, Sunahara RK. The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination. The Journal of Pharmacology and Experimental Therapeutics. 340: 83-95. PMID 21990608 DOI: 10.1124/Jpet.111.186049  0.792
2011 Brim RL, Noon KR, Collins GT, Nichols J, Narasimhan D, Sunahara RK, Woods JH. The ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometry. Molecular Pharmacology. 80: 1119-27. PMID 21885621 DOI: 10.1124/Mol.111.074534  0.794
2011 Brim RL, Noon KR, Nichols J, Narasimhan D, Woods JH, Sunahara RK. Evaluation of the hydrolytic activity of a long-acting mutant bacterial cocaine in the presence of commonly co-administered drugs. Drug and Alcohol Dependence. 119: 224-8. PMID 21775073 DOI: 10.1016/J.Drugalcdep.2011.06.018  0.859
2010 Brim RL, Nance MR, Youngstrom DW, Narasimhan D, Zhan CG, Tesmer JJ, Sunahara RK, Woods JH. A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse. Molecular Pharmacology. 77: 593-600. PMID 20086035 DOI: 10.1124/Mol.109.060806  0.867
2010 Park JB, Kwon YM, Lee TY, Brim R, Ko MC, Sunahara RK, Woods JH, Yang VC. PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity. Journal of Controlled Release : Official Journal of the Controlled Release Society. 142: 174-9. PMID 19857534 DOI: 10.1016/J.Jconrel.2009.10.015  0.833
2009 Collins GT, Brim RL, Narasimhan D, Ko MC, Sunahara RK, Zhan CG, Woods JH. Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats. The Journal of Pharmacology and Experimental Therapeutics. 331: 445-55. PMID 19710369 DOI: 10.1124/Jpet.108.150029  0.787
2009 Gao D, Narasimhan DL, Macdonald J, Brim R, Ko MC, Landry DW, Woods JH, Sunahara RK, Zhan CG. Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity. Molecular Pharmacology. 75: 318-23. PMID 18987161 DOI: 10.1124/Mol.108.049486  0.846
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