| Year |
Citation |
Score |
| 2022 |
Bjork RT, Mortimore NP, Loganathan S, Zarnescu DC. Dysregulation of Translation in TDP-43 Proteinopathies: Deficits in the RNA Supply Chain and Local Protein Production. Frontiers in Neuroscience. 16: 840357. PMID 35321094 DOI: 10.3389/fnins.2022.840357 |
0.367 |
|
| 2021 |
Lehmkuhl EM, Loganathan S, Alsop E, Blythe AD, Kovalik T, Mortimore NP, Barrameda D, Kueth C, Eck RJ, Siddegowda BB, Joardar A, Ball H, Macias ME, Bowser R, Van Keuren-Jensen K, ... Zarnescu DC, et al. TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6. Acta Neuropathologica Communications. 9: 52. PMID 33762006 DOI: 10.1186/s40478-021-01148-z |
0.348 |
|
| 2019 |
Loganathan S, Lehmkuhl EM, Eck RJ, Zarnescu DC. To Be or Not To Be…Toxic-Is RNA Association With TDP-43 Complexes Deleterious or Protective in Neurodegeneration? Frontiers in Molecular Biosciences. 6: 154. PMID 31998750 DOI: 10.3389/fmolb.2019.00154 |
0.382 |
|
| 2019 |
Francois-Moutal L, Scott DD, Felemban R, Miranda VG, Sayegh MR, Perez-Miller S, Khanna R, Gokhale V, Zarnescu DC, Khanna M. A small molecule targeting TDP-43's RNA recognition motifs reduces locomotor defects in a Drosophila model of ALS. Acs Chemical Biology. PMID 31241884 DOI: 10.1021/Acschembio.9B00481 |
0.399 |
|
| 2019 |
Manzo E, Lorenzini I, Barrameda D, O'Conner AG, Barrows JM, Starr A, Kovalik T, Rabichow BE, Lehmkuhl EM, Shreiner DD, Joardar A, Liévens JC, Bowser R, Sattler R, Zarnescu DC. Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS. Elife. 8. PMID 31180318 DOI: 10.7554/Elife.45114 |
0.329 |
|
| 2018 |
Lehmkuhl EM, Zarnescu DC. Lost in Translation: Evidence for Protein Synthesis Deficits in ALS/FTD and Related Neurodegenerative Diseases. Advances in Neurobiology. 20: 283-301. PMID 29916024 DOI: 10.1007/978-3-319-89689-2_11 |
0.385 |
|
| 2018 |
Ferro D, Yao S, Zarnescu DC. Dynamic duo - FMRP and TDP-43: regulating common targets, causing different diseases. Brain Research. PMID 29715444 DOI: 10.1016/j.brainres.2018.04.034 |
0.457 |
|
| 2018 |
Chou CC, Zhang Y, Umoh ME, Vaughan SW, Lorenzini I, Liu F, Sayegh M, Donlin-Asp PG, Chen YH, Duong DM, Seyfried NT, Powers MA, Kukar T, Hales CM, Gearing M, ... ... Zarnescu DC, et al. TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD. Nature Neuroscience. PMID 29311743 DOI: 10.1038/S41593-017-0047-3 |
0.396 |
|
| 2017 |
Daniel SG, Russ AD, Guthridge KM, Raina AI, Estes PS, Parsons LM, Richardson HE, Schroeder JA, Zarnescu DC. miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila. Biology Open. PMID 29361610 DOI: 10.1242/Bio.027391 |
0.732 |
|
| 2017 |
Liu G, Coyne AN, Pei F, Vaughan S, Chaung M, Zarnescu DC, Buchan JR. Endocytosis regulates TDP-43 toxicity and turnover. Nature Communications. 8: 2092. PMID 29233983 DOI: 10.1038/S41467-017-02017-X |
0.646 |
|
| 2017 |
Chu M, Novak SM, Cover C, Wang AA, Chinyere IR, Juneman E, Zarnescu DC, Wong PK, Gregorio C. Increased Cardiac Arrhythmogenesis Associated with Gap Junction Remodeling with Upregulation of RNA Binding Protein FXR1. Circulation. PMID 29101288 DOI: 10.1161/Circulationaha.117.028976 |
0.434 |
|
| 2017 |
Coyne AN, Lorenzini I, Chou CC, Torvund M, Rogers RS, Starr A, Zaepfel BL, Levy J, Johannesmeyer J, Schwartz JC, Nishimune H, Zinsmaier K, Rossoll W, Sattler R, Zarnescu DC. Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS. Cell Reports. 21: 110-125. PMID 28978466 DOI: 10.1016/J.Celrep.2017.09.028 |
0.674 |
|
| 2017 |
Coyne AN, Zaepfel BL, Zarnescu DC. Failure to Deliver and Translate-New Insights into RNA Dysregulation in ALS. Frontiers in Cellular Neuroscience. 11: 243. PMID 28860970 DOI: 10.3389/fncel.2017.00243 |
0.652 |
|
| 2016 |
Coyne AN, Zarnescu DC. A Helping Hand: RNA-Binding Proteins Guide Gene-Binding Choices by Cohesin Complexes. Plos Genetics. 12: e1006419. PMID 27855157 DOI: 10.1371/journal.pgen.1006419 |
0.617 |
|
| 2015 |
Novak SM, Joardar A, Gregorio CC, Zarnescu DC. Regulation of Heart Rate in Drosophila via Fragile X Mental Retardation Protein. Plos One. 10: e0142836. PMID 26571124 DOI: 10.1371/Journal.Pone.0142836 |
0.452 |
|
| 2015 |
Coyne AN, Yamada SB, Siddegowda BB, Estes PS, Zaepfel BL, Johannesmeyer JS, Lockwood DB, Pham LT, Hart MP, Cassel JA, Freibaum B, Boehringer AV, Taylor JP, Reitz AB, Gitler AD, ... Zarnescu DC, et al. Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation. Human Molecular Genetics. PMID 26385636 DOI: 10.1093/Hmg/Ddv389 |
0.697 |
|
| 2015 |
Chou CC, Alexeeva OM, Yamada S, Pribadi A, Zhang Y, Mo B, Williams KR, Zarnescu DC, Rossoll W. PABPN1 suppresses TDP-43 toxicity in ALS disease models. Human Molecular Genetics. PMID 26130692 DOI: 10.1093/Hmg/Ddv238 |
0.431 |
|
| 2015 |
Joardar A, Menzl J, Podolsky TC, Manzo E, Estes PS, Ashford S, Zarnescu DC. PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43. Human Molecular Genetics. 24: 1741-54. PMID 25432537 DOI: 10.1093/hmg/ddu587 |
0.333 |
|
| 2014 |
Coyne AN, Siddegowda BB, Estes PS, Johannesmeyer J, Kovalik T, Daniel SG, Pearson A, Bowser R, Zarnescu DC. Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15962-74. PMID 25429138 DOI: 10.1523/Jneurosci.2526-14.2014 |
0.673 |
|
| 2013 |
Zarnescu DC, Gregorio CC. Fragile hearts: new insights into translational control in cardiac muscle. Trends in Cardiovascular Medicine. 23: 275-81. PMID 23582851 DOI: 10.1016/J.Tcm.2013.03.003 |
0.365 |
|
| 2013 |
Estes PS, Daniel SG, McCallum AP, Boehringer AV, Sukhina AS, Zwick RA, Zarnescu DC. Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis. Disease Models & Mechanisms. 6: 721-33. PMID 23471911 DOI: 10.1242/dmm.010710 |
0.394 |
|
| 2012 |
Russ A, Louderbough JM, Zarnescu D, Schroeder JA. Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation. Plos One. 7: e47734. PMID 23110097 DOI: 10.1371/Journal.Pone.0047734 |
0.757 |
|
| 2012 |
Callan MA, Clements N, Ahrendt N, Zarnescu DC. Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain. Brain Research. 1462: 151-61. PMID 22513101 DOI: 10.1016/J.Brainres.2012.03.042 |
0.76 |
|
| 2011 |
Whitman SA, Cover C, Yu L, Nelson DL, Zarnescu DC, Gregorio CC. Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle. Circulation Research. 109: 262-71. PMID 21659647 DOI: 10.1161/Circresaha.111.244244 |
0.381 |
|
| 2011 |
Estes PS, Boehringer A, Zwick R, Tang JE, Grigsby B, Zarnescu DC. Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS. Human Molecular Genetics. 20: 2308-21. PMID 21441568 DOI: 10.1093/hmg/ddr124 |
0.411 |
|
| 2011 |
Callan MA, Zarnescu DC. Heads-up: new roles for the fragile X mental retardation protein in neural stem and progenitor cells. Genesis (New York, N.Y. : 2000). 49: 424-40. PMID 21404421 DOI: 10.1002/Dvg.20745 |
0.767 |
|
| 2010 |
Callan MA, Cabernard C, Heck J, Luois S, Doe CQ, Zarnescu DC. Fragile X protein controls neural stem cell proliferation in the Drosophila brain. Human Molecular Genetics. 19: 3068-79. PMID 20504994 DOI: 10.1093/Hmg/Ddq213 |
0.759 |
|
| 2010 |
Lee HG, Zarnescu DC, MacIver B, Thomas GH. The cell adhesion molecule Roughest depends on beta(Heavy)-spectrin during eye morphogenesis in Drosophila. Journal of Cell Science. 123: 277-85. PMID 20048344 DOI: 10.1242/jcs.056853 |
0.721 |
|
| 2010 |
Lee H, Zarnescu DC, MacIver B, Thomas GH. The cell adhesion molecule Roughest depends on βHeavy-spectrin during eye morphogenesis in Drosophila Development. 137. DOI: 10.1242/Dev.048256 |
0.657 |
|
| 2009 |
Zarnescu DC, Zinsmaier KE. Ferrying wingless across the synaptic cleft. Cell. 139: 229-31. PMID 19837027 DOI: 10.1016/J.Cell.2009.09.032 |
0.376 |
|
| 2009 |
Cziko AM, McCann CT, Howlett IC, Barbee SA, Duncan RP, Luedemann R, Zarnescu D, Zinsmaier KE, Parker RR, Ramaswami M. Genetic modifiers of dFMR1 encode RNA granule components in Drosophila. Genetics. 182: 1051-60. PMID 19487564 DOI: 10.1534/Genetics.109.103234 |
0.455 |
|
| 2009 |
Epstein AM, Bauer CR, Ho A, Bosco G, Zarnescu DC. Drosophila Fragile X protein controls cellular proliferation by regulating cbl levels in the ovary. Developmental Biology. 330: 83-92. PMID 19306863 DOI: 10.1016/j.ydbio.2009.03.011 |
0.487 |
|
| 2008 |
Bauer CR, Epstein AM, Sweeney SJ, Zarnescu DC, Bosco G. Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks. Bmc Systems Biology. 2: 101. PMID 19032789 DOI: 10.1186/1752-0509-2-101 |
0.353 |
|
| 2008 |
Estes PS, O'Shea M, Clasen S, Zarnescu DC. Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons. Molecular and Cellular Neurosciences. 39: 170-9. PMID 18655836 DOI: 10.1016/j.mcn.2008.06.012 |
0.411 |
|
| 2008 |
Chang S, Bray SM, Li Z, Zarnescu DC, He C, Jin P, Warren ST. Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nature Chemical Biology. 4: 256-63. PMID 18327252 DOI: 10.1038/Nchembio.78 |
0.344 |
|
| 2005 |
Zarnescu DC, Shan G, Warren ST, Jin P. Come FLY with us: toward understanding fragile X syndrome. Genes, Brain, and Behavior. 4: 385-92. PMID 16098136 DOI: 10.1111/J.1601-183X.2005.00136.X |
0.336 |
|
| 2005 |
Zarnescu DC, Jin P, Betschinger J, Nakamoto M, Wang Y, Dockendorff TC, Feng Y, Jongens TA, Sisson JC, Knoblich JA, Warren ST, Moses K. Fragile X protein functions with lgl and the par complex in flies and mice. Developmental Cell. 8: 43-52. PMID 15621528 DOI: 10.1016/J.Devcel.2004.10.020 |
0.642 |
|
| 2004 |
Zarnescu DC, Moses K. Born again at the synapse: a new function for the anaphase promoting complex/cyclosome. Developmental Cell. 7: 777-8. PMID 15572119 DOI: 10.1016/j.devcel.2004.11.011 |
0.562 |
|
| 2004 |
Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K, Warren ST. Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nature Neuroscience. 7: 113-7. PMID 14703574 DOI: 10.1038/Nn1174 |
0.671 |
|
| 2003 |
Jin P, Zarnescu DC, Zhang F, Pearson CE, Lucchesi JC, Moses K, Warren ST. RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila. Neuron. 39: 739-47. PMID 12948442 DOI: 10.1016/S0896-6273(03)00533-6 |
0.628 |
|
| 2002 |
Médina E, Williams J, Klipfell E, Zarnescu D, Thomas G, Bivic AL. Crumbs interacts with moesin and βHeavy-spectrin in the apical membrane skeleton of Drosophila Journal of Cell Biology. 158: 941-951. PMID 12213838 DOI: 10.1083/Jcb.200203080 |
0.711 |
|
| 1999 |
Zarnescu DC, Thomas GH. Apical spectrin is essential for epithelial morphogenesis but not apicobasal polarity in Drosophila. The Journal of Cell Biology. 146: 1075-86. PMID 10477760 DOI: 10.1083/jcb.146.5.1075 |
0.536 |
|
| 1998 |
Thomas GH, Zarnescu DC, Juedes AE, Bales MA, Londergan A, Korte CC, Kiehart DP. Drosophila betaHeavy-spectrin is essential for development and contributes to specific cell fates in the eye. Development (Cambridge, England). 125: 2125-34. PMID 9570776 |
0.503 |
|
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