Jonathan L. Sebat, Ph.D. - Publications

Affiliations: 
2002 University of Idaho, Moscow, ID, United States 
Area:
Microbiology Biology, Genetics, Molecular Biology

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Shanta O, Noor A, Sebat J. The effects of common structural variants on 3D chromatin structure. Bmc Genomics. 21: 95. PMID 32000688 DOI: 10.1186/S12864-020-6516-1  0.331
2020 Foley C, Heron EA, Harold D, Walters J, Owen M, O'Donovan M, Sebat J, Kelleher E, Mooney C, Durand A, Pinto C, Cormican P, Morris D, Donohoe G, Gill M, et al. Identifying schizophrenia patients who carry pathogenic genetic copy number variants using standard clinical assessment: retrospective cohort study. The British Journal of Psychiatry : the Journal of Mental Science. 1-5. PMID 31964429 DOI: 10.1192/Bjp.2019.262  0.348
2019 Breuss MW, Antaki D, George RD, Kleiber M, James KN, Ball LL, Hong O, Mitra I, Yang X, Wirth SA, Gu J, Garcia CAB, Gujral M, Brandler WM, Musaev D, ... ... Sebat J, et al. Autism risk in offspring can be assessed through quantification of male sperm mosaicism. Nature Medicine. PMID 31873310 DOI: 10.1038/S41591-019-0711-0  0.339
2019 Wells A, Heckerman D, Torkamani A, Yin L, Sebat J, Ren B, Telenti A, di Iulio J. Ranking of non-coding pathogenic variants and putative essential regions of the human genome. Nature Communications. 10: 5241. PMID 31748530 DOI: 10.1038/S41467-019-13212-3  0.347
2019 Qiu Y, Arbogast T, Lorenzo SM, Li H, Tang SC, Richardson E, Hong O, Cho S, Shanta O, Pang T, Corsello C, Deutsch CK, Chevalier C, Davis EE, Iakoucheva LM, ... ... Sebat J, et al. Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development. Cell Reports. 28: 3320-3328.e4. PMID 31553903 DOI: 10.1016/J.Celrep.2019.08.071  0.357
2019 Sanders SJ, Sahin M, Hostyk J, Thurm A, Jacquemont S, Avillach P, Douard E, Martin CL, Modi ME, Moreno-De-Luca A, Raznahan A, Anticevic A, Dolmetsch R, Feng G, Geschwind DH, ... ... Sebat J, et al. A framework for the investigation of rare genetic disorders in neuropsychiatry. Nature Medicine. PMID 31548702 DOI: 10.1038/S41591-019-0581-5  0.344
2019 Iakoucheva LM, Muotri AR, Sebat J. Getting to the Cores of Autism Cell. 178: 1287-1298. PMID 31491383 DOI: 10.1016/J.Cell.2019.07.037  0.342
2019 Bodkin JA, Coleman MJ, Godfrey LJ, Carvalho CMB, Morgan CJ, Suckow RF, Anderson T, Ongur D, Kaufman MJ, Lewandowski KE, Siegel AJ, Waldstreicher E, Grochowski CM, Javitt DC, Rujescu D, ... ... Sebat J, et al. Targeted Treatment of Individuals With Psychosis Carrying a Copy Number Variant Containing a Genomic Triplication of the Glycine Decarboxylase Gene. Biological Psychiatry. PMID 31279534 DOI: 10.1016/J.Biopsych.2019.04.031  0.356
2019 Pagel KA, Antaki D, Lian A, Mort M, Cooper DN, Sebat J, Iakoucheva LM, Mooney SD, Radivojac P. Pathogenicity and functional impact of non-frameshifting insertion/deletion variation in the human genome. Plos Computational Biology. 15: e1007112. PMID 31199787 DOI: 10.1371/Journal.Pcbi.1007112  0.378
2019 Chaisson MJP, Sanders AD, Zhao X, Malhotra A, Porubsky D, Rausch T, Gardner EJ, Rodriguez OL, Guo L, Collins RL, Fan X, Wen J, Handsaker RE, Fairley S, Kronenberg ZN, ... ... Sebat J, et al. Multi-platform discovery of haplotype-resolved structural variation in human genomes. Nature Communications. 10: 1784. PMID 30992455 DOI: 10.1038/S41467-018-08148-Z  0.37
2019 Charney A, Sebat J, MacDonald J. Rare Copy Number Variation And Common Polygenic Risk In Bipolar Disorder Subtypes European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2019.07.039  0.307
2019 Zayats T, Martin J, Thiruvahindrapuram B, Wang Z, Howrigan D, Shanta O, Neale B, Sebat J. A Contribution Of Rare Copy Number Variations To The Development Of Attention Deficit Hyperactivity Disorder: Genome-Wide Meta-Analyses In 12548 Individuals European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2018.07.045  0.334
2019 Sebat J, Agrawal A, Børglum A. New Findings From Young Investigators In The Psychiatric Genomics Consortium European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2018.07.004  0.318
2018 Bergen SE, Ploner A, Howrigan D, O'Donovan MC, Smoller JW, Sullivan PF, Sebat J, Neale B, Kendler KS. Joint Contributions of Rare Copy Number Variants and Common SNPs to Risk for Schizophrenia. The American Journal of Psychiatry. appiajp201817040467. PMID 30392412 DOI: 10.1176/Appi.Ajp.2018.17040467  0.31
2018 Grochowski CM, Gu S, Yuan B, Tcw J, Brennand KJ, Sebat J, Malhotra D, McCarthy S, Rudolph U, Lindstrand A, Chong Z, Levy DL, Lupski JR, Carvalho CMB. Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes. Human Mutation. PMID 29696747 DOI: 10.1002/Humu.23537  0.368
2018 Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, Pang T, Tang SC, Vaux KK, Yang Y, Harrington E, ... ... Sebat J, et al. Paternally inherited cis-regulatory structural variants are associated with autism. Science (New York, N.Y.). 360: 327-331. PMID 29674594 DOI: 10.1126/Science.Aan2261  0.362
2018 Antaki D, Brandler WM, Sebat J. SV2: accurate structural variation genotyping and de novo mutation detection from whole genomes. Bioinformatics. 34: 1774-1777. PMID 29300834 DOI: 10.1093/Bioinformatics/Btx813  0.336
2017 Pagel KA, Pejaver V, Lin GN, Nam HJ, Mort M, Cooper DN, Sebat J, Iakoucheva LM, Mooney SD, Radivojac P. When loss-of-function is loss of function: assessing mutational signatures and impact of loss-of-function genetic variants. Bioinformatics (Oxford, England). 33: i389-i398. PMID 28882004 DOI: 10.1093/Bioinformatics/Btx272  0.314
2017 Levy D, Coleman M, Godfrey L, Morgan C, Sebat J, Ongur D, McCarthy S, Malhotra D, Vuckovic A, Smith K, Kirchhoff C, Suckow R, Coyle J, Rudolph U, Goff D, et al. SU93. Targeted Treatment of a Genetic Mutation in Glycine Decarboxylase With d-Cycloserine in Psychotic Disorders Schizophrenia Bulletin. 43: S194-S195. DOI: 10.1093/Schbul/Sbx024.089  0.303
2016 Brandler WM, Antaki D, Gujral M, Noor A, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fajardo KV, ... ... Sebat J, et al. Frequency and Complexity of De Novo Structural Mutation in Autism. American Journal of Human Genetics. PMID 27018473 DOI: 10.1016/J.Ajhg.2016.02.018  0.395
2015 Sudmant PH, Rausch T, Gardner EJ, Handsaker RE, Abyzov A, Huddleston J, Zhang Y, Ye K, Jun G, Hsi-Yang Fritz M, Konkel MK, Malhotra A, Stütz AM, Shi X, Paolo Casale F, ... ... Sebat J, et al. An integrated map of structural variation in 2,504 human genomes. Nature. 526: 75-81. PMID 26432246 DOI: 10.1038/Nature15394  0.382
2015 Kusenda M, Vacic V, Malhotra D, Rodgers L, Pavon K, Meth J, Kumar RA, Christian SL, Peeters H, Cho SS, Addington A, Rapoport JL, Sebat J. The Influence of Microdeletions and Microduplications of 16p11.2 on Global Transcription Profiles. Journal of Child Neurology. PMID 26391891 DOI: 10.1177/0883073815602066  0.334
2015 Lin GN, Corominas R, Lemmens I, Yang X, Tavernier J, Hill DE, Vidal M, Sebat J, Iakoucheva LM. Spatiotemporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases. Neuron. 85: 742-54. PMID 25695269 DOI: 10.1016/J.Neuron.2015.01.010  0.324
2015 Brandler WM, Sebat J. From De Novo Mutations to Personalized Therapeutic Interventions in Autism Annual Review of Medicine. 66: 487-507. PMID 25587659 DOI: 10.1146/Annurev-Med-091113-024550  0.368
2014 Mulle JG, Pulver AE, McGrath JA, Wolyniec PS, Dodd AF, Cutler DJ, Sebat J, Malhotra D, Nestadt G, Conrad DF, Hurles M, Barnes CP, Ikeda M, Iwata N, Levinson DF, et al. Reciprocal duplication of the Williams-Beuren syndrome deletion on chromosome 7q11.23 is associated with schizophrenia. Biological Psychiatry. 75: 371-7. PMID 23871472 DOI: 10.1016/J.Biopsych.2013.05.040  0.365
2013 Rippey C, Walsh T, Gulsuner S, Brodsky M, Nord AS, Gasperini M, Pierce S, Spurrell C, Coe BP, Krumm N, Lee MK, Sebat J, McClellan JM, King MC. Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia. American Journal of Human Genetics. 93: 697-710. PMID 24094746 DOI: 10.1016/J.Ajhg.2013.09.004  0.356
2013 Guha S, Rees E, Darvasi A, Ivanov D, Ikeda M, Bergen SE, Magnusson PK, Cormican P, Morris D, Gill M, Cichon S, Rosenfeld JA, Lee A, Gregersen PK, Kane JM, ... ... Sebat J, et al. Implication of a rare deletion at distal 16p11.2 in schizophrenia. Jama Psychiatry. 70: 253-60. PMID 23325106 DOI: 10.1001/2013.Jamapsychiatry.71  0.373
2012 Michaelson JJ, Shi Y, Gujral M, Zheng H, Malhotra D, Jin X, Jian M, Liu G, Greer D, Bhandari A, Wu W, Corominas R, Peoples A, Koren A, Gore A, ... ... Sebat J, et al. Whole-genome sequencing in autism identifies hot spots for de novo germline mutation. Cell. 151: 1431-42. PMID 23260136 DOI: 10.1016/J.Cell.2012.11.019  0.382
2012 Koren A, Polak P, Nemesh J, Michaelson JJ, Sebat J, Sunyaev SR, McCarroll SA. Differential relationship of DNA replication timing to different forms of human mutation and variation. American Journal of Human Genetics. 91: 1033-40. PMID 23176822 DOI: 10.1016/J.Ajhg.2012.10.018  0.34
2012 Malhotra D, Sebat J. Genetics: Fish heads and human disease. Nature. 485: 318-319. PMID 22596152 DOI: 10.1038/485318A  0.42
2012 Malhotra D, Sebat J. CNVs: harbingers of a rare variant revolution in psychiatric genetics. Cell. 148: 1223-1241. PMID 22424231 DOI: 10.1016/J.Cell.2012.02.039  0.407
2011 Kato M, Yoon S, Hosono N, Leotta A, Sebat J, Tsunoda T, Zhang MQ. Inferring haplotypes of copy number variations from high-throughput data with uncertainty. G3 (Bethesda, Md.). 1: 35-42. PMID 22384316 DOI: 10.1534/G3.111.000174  0.307
2011 Malhotra D, McCarthy S, Michaelson JJ, Vacic V, Burdick KE, Yoon S, Cichon S, Corvin A, Gary S, Gershon ES, Gill M, Karayiorgou M, Kelsoe JR, Krastoshevsky O, Krause V, ... ... Sebat J, et al. High frequencies of de novo CNVs in bipolar disorder and schizophrenia. Neuron. 72: 951-63. PMID 22196331 DOI: 10.1016/J.Neuron.2011.11.007  0.349
2011 Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S, Sebat J, Gage FH. Modelling schizophrenia using human induced pluripotent stem cells. Nature. 473: 221-5. PMID 21490598 DOI: 10.1038/Nature09915  0.314
2011 Nord AS, Roeb W, Dickel DE, Walsh T, Kusenda M, O'Connor KL, Malhotra D, McCarthy SE, Stray SM, Taylor SM, Sebat J, King B, King MC, McClellan JM. Reduced transcript expression of genes affected by inherited and de novo CNVs in autism. European Journal of Human Genetics : Ejhg. 19: 727-31. PMID 21448237 DOI: 10.1038/Ejhg.2011.24  0.377
2011 Vacic V, McCarthy S, Malhotra D, Murray F, Chou HH, Peoples A, Makarov V, Yoon S, Bhandari A, Corominas R, Iakoucheva LM, Krastoshevsky O, Krause V, Larach-Walters V, Welsh DK, ... ... Sebat J, et al. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature. 471: 499-503. PMID 21346763 DOI: 10.1038/Nature09884  0.348
2011 Mills RE, Walter K, Stewart C, Handsaker RE, Chen K, Alkan C, Abyzov A, Yoon SC, Ye K, Cheetham RK, Chinwalla A, Conrad DF, Fu Y, Grubert F, Hajirasouliha I, ... ... Sebat J, et al. Mapping copy number variation by population-scale genome sequencing. Nature. 470: 59-65. PMID 21293372 DOI: 10.1038/Nature09708  0.357
2010 Zhou X, Nie Z, Roberts A, Zhang D, Sebat J, Malhotra D, Kelsoe JR, Geyer MA. Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders. Human Molecular Genetics. 19: 3797-805. PMID 20634195 DOI: 10.1093/Hmg/Ddq298  0.31
2010 Girirajan S, Rosenfeld JA, Cooper GM, Antonacci F, Siswara P, Itsara A, Vives L, Walsh T, McCarthy SE, Baker C, Mefford HC, Kidd JM, Browning SR, Browning BL, Dickel DE, ... ... Sebat J, et al. A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay. Nature Genetics. 42: 203-9. PMID 20154674 DOI: 10.1038/Ng.534  0.327
2010 Aberg K, Adkins DE, Bukszár J, Webb BT, Caroff SN, Miller DD, Sebat J, Stroup S, Fanous AH, Vladimirov VI, McClay JL, Lieberman JA, Sullivan PF, van den Oord EJ. Genomewide association study of movement-related adverse antipsychotic effects. Biological Psychiatry. 67: 279-82. PMID 19875103 DOI: 10.1016/J.Biopsych.2009.08.036  0.304
2009 Sebat J, Levy DL, McCarthy SE. Rare structural variants in schizophrenia: one disorder, multiple mutations; one mutation, multiple disorders. Trends in Genetics : Tig. 25: 528-35. PMID 19883952 DOI: 10.1016/J.Tig.2009.10.004  0.371
2009 McCarthy SE, Makarov V, Kirov G, Addington AM, McClellan J, Yoon S, Perkins DO, Dickel DE, Kusenda M, Krastoshevsky O, Krause V, Kumar RA, Grozeva D, Malhotra D, Walsh T, ... ... Sebat J, et al. Microduplications of 16p11.2 are associated with schizophrenia. Nature Genetics. 41: 1223-7. PMID 19855392 DOI: 10.1038/Ng.474  0.327
2009 Yoon S, Xuan Z, Makarov V, Ye K, Sebat J. Sensitive and accurate detection of copy number variants using read depth of coverage. Genome Research. 19: 1586-92. PMID 19657104 DOI: 10.1101/Gr.092981.109  0.364
2008 Kusenda M, Sebat J. The role of rare structural variants in the genetics of autism spectrum disorders Cytogenetic and Genome Research. 123: 36-43. PMID 19287137 DOI: 10.1159/000184690  0.389
2008 Mefford HC, Sharp AJ, Baker C, Itsara A, Jiang Z, Buysse K, Huang S, Maloney VK, Crolla JA, Baralle D, Collins A, Mercer C, Norga K, de Ravel T, Devriendt K, ... ... Sebat J, et al. Recurrent rearrangements of chromosome 1q21.1 and variable pediatric phenotypes. The New England Journal of Medicine. 359: 1685-99. PMID 18784092 DOI: 10.1056/Nejmoa0805384  0.323
2008 Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, Cooper GM, Nord AS, Kusenda M, Malhotra D, Bhandari A, Stray SM, Rippey CF, Roccanova P, Makarov V, Lakshmi B, ... ... Sebat J, et al. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science (New York, N.Y.). 320: 539-43. PMID 18369103 DOI: 10.1126/Science.1155174  0.379
2008 Alarcón M, Abrahams BS, Stone JL, Duvall JA, Perederiy JV, Bomar JM, Sebat J, Wigler M, Martin CL, Ledbetter DH, Nelson SF, Cantor RM, Geschwind DH. Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. American Journal of Human Genetics. 82: 150-9. PMID 18179893 DOI: 10.1016/J.Ajhg.2007.09.005  0.349
2007 Lucito R, Suresh S, Walter K, Pandey A, Lakshmi B, Krasnitz A, Sebat J, Wigler M, Klein AP, Brune K, Palmisano E, Maitra A, Goggins M, Hruban RH. Copy-number variants in patients with a strong family history of pancreatic cancer. Cancer Biology & Therapy. 6: 1592-9. PMID 17912030 DOI: 10.4161/Cbt.6.10.4725  0.318
2007 Sebat J. Major changes in our DNA lead to major changes in our thinking. Nature Genetics. 39. PMID 17597778 DOI: 10.1038/Ng2095  0.368
2007 Eichler EE, Nickerson DA, Altshuler D, Bowcock AM, Brooks LD, Carter NP, Church DM, Felsenfeld A, Guyer M, Lee C, Lupski JR, Mullikin JC, Pritchard JK, Sebat J, et al. Completing the map of human genetic variation. Nature. 447: 161-5. PMID 17495918 DOI: 10.1038/447161A  0.362
2007 Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T, Yamrom B, Yoon S, Krasnitz A, Kendall J, Leotta A, Pai D, Zhang R, Lee YH, Hicks J, et al. Strong association of de novo copy number mutations with autism. Science (New York, N.Y.). 316: 445-9. PMID 17363630 DOI: 10.1126/Science.1138659  0.42
2006 Navin N, Grubor V, Hicks J, Leibu E, Thomas E, Troge J, Riggs M, Lundin P, MÃ¥nér S, Sebat J, Zetterberg A, Wigler M. PROBER: oligonucleotide FISH probe design software. Bioinformatics (Oxford, England). 22: 2437-8. PMID 16740623 DOI: 10.1093/Bioinformatics/Btl273  0.331
2006 Sebat J, Lakshmi B, Troge J, Martin C, Spence S, Ledbetter D, Gilliam TC, Ye K, Geschwind D, Sutcliffe J, Wigler MH. High-resolution analysis of genome copy number variation in autism International Journal of Developmental Neuroscience. 24: 474. DOI: 10.1016/J.Ijdevneu.2006.09.013  0.347
2005 Jobanputra V, Sebat J, Troge J, Chung W, Anyane-Yeboa K, Wigler M, Warburton D. Application of ROMA (representational oligonucleotide microarray analysis) to patients with cytogenetic rearrangements. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 7: 111-8. PMID 15714078 DOI: 10.1097/01.Gim.0000153661.11110.Fb  0.317
2004 Sebat J, Lakshmi B, Troge J, Alexander J, Young J, Lundin P, MÃ¥nér S, Massa H, Walker M, Chi M, Navin N, Lucito R, Healy J, Hicks J, Ye K, et al. Large-scale copy number polymorphism in the human genome. Science (New York, N.Y.). 305: 525-8. PMID 15273396 DOI: 10.1126/Science.1098918  0.372
2004 Thomas EE, Srebro N, Sebat J, Navin N, Healy J, Mishra B, Wigler M. Distribution of short paired duplications in mammalian genomes. Proceedings of the National Academy of Sciences of the United States of America. 101: 10349-54. PMID 15240876 DOI: 10.1073/Pnas.0403727101  0.324
2003 Lucito R, Healy J, Alexander J, Reiner A, Esposito D, Chi M, Rodgers L, Brady A, Sebat J, Troge J, West JA, Rostan S, Nguyen KC, Powers S, Ye KQ, et al. Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation. Genome Research. 13: 2291-305. PMID 12975311 DOI: 10.1101/Gr.1349003  0.358
2003 Sebat JL, Colwell FS, Crawford RL. Metagenomic profiling: microarray analysis of an environmental genomic library. Applied and Environmental Microbiology. 69: 4927-34. PMID 12902288 DOI: 10.1128/Aem.69.8.4927-4934.2003  0.56
2002 Cortese MS, Paszczynski A, Lewis TA, Sebat JL, Borek V, Crawford RL. Metal chelating properties of pyridine-2,6-bis(thiocarboxylic acid) produced by Pseudomonas spp. and the biological activities of the formed complexes. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 15: 103-20. PMID 12046919 DOI: 10.1023/A:1015241925322  0.676
2001 Sebat JL, Paszczynski AJ, Cortese MS, Crawford RL. Antimicrobial properties of pyridine-2,6-dithiocarboxylic acid, a metal chelator produced by Pseudomonas spp. Applied and Environmental Microbiology. 67: 3934-42. PMID 11525988 DOI: 10.1128/Aem.67.9.3934-3942.2001  0.685
2000 Lewis TA, Cortese MS, Sebat JL, Green TL, Lee CH, Crawford RL. A Pseudomonas stutzeri gene cluster encoding the biosynthesis of the CCl4-dechlorination agent pyridine-2,6-bis(thiocarboxylic acid). Environmental Microbiology. 2: 407-16. PMID 11234929 DOI: 10.1046/J.1462-2920.2000.00122.X  0.699
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