Salil A. Lachke, Ph.D. - Publications

Affiliations: 
2011- Department of Biological Sciences University of Delaware, Newark, DE, United States 
Area:
Biology

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Tangeman JA, Rebull SM, Grajales-Esquivel E, Weaver JM, Bendezu-Sayas S, Robinson ML, Lachke SA, Del Rio-Tsonis K. Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology. Development (Cambridge, England). 151. PMID 38180241 DOI: 10.1242/dev.202249  0.379
2023 Duot M, Viel R, Viet J, Le Goff-Gaillard C, Paillard L, Lachke SA, Gautier-Courteille C, Reboutier D. Eye Lens Organoids Made Simple: Characterization of a New Three-Dimensional Organoid Model for Lens Development and Pathology. Cells. 12. PMID 37887322 DOI: 10.3390/cells12202478  0.429
2023 Duot M, Viel R, Viet J, Le Goff-Gaillard C, Paillard L, Lachke SA, Gautier-Courteille C, Reboutier D. Eye lens organoids going simple: characterization of a new 3-dimensional organoid model for lens development and pathology. Biorxiv : the Preprint Server For Biology. PMID 37503005 DOI: 10.1101/2023.07.12.548679  0.412
2023 Tangeman JA, Rebull SM, Grajales-Esquivel E, Weaver JM, Bendezu-Sayas S, Robinson ML, Lachke SA, Rio-Tsonis KD. Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology. Biorxiv : the Preprint Server For Biology. PMID 37502967 DOI: 10.1101/2023.07.10.548451  0.38
2023 Aryal S, Anand D, Huang H, Reddy AP, Wilmarth PA, David LL, Lachke SA. Proteomic profiling of retina and retinal pigment epithelium combined embryonic tissue to facilitate ocular disease gene discovery. Human Genetics. PMID 37191732 DOI: 10.1007/s00439-023-02570-0  0.684
2023 Siddam AD, Duot M, Coomson SY, Anand D, Aryal S, Weatherbee BAT, Audic Y, Paillard L, Lachke SA. High-Throughput Transcriptomics of Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology. Cells. 12. PMID 37048143 DOI: 10.3390/cells12071070  0.847
2023 Aryal S, Anand D, Huang H, Reddy AP, Wilmarth PA, David LL, Lachke SA. Proteomic profiling of retina and retinal pigment epithelium combined embryonic tissue to facilitate ocular disease gene discovery. Research Square. PMID 36993571 DOI: 10.21203/rs.3.rs-2652395/v1  0.684
2023 Upreti A, Padula SL, Tangeman JA, Wagner BD, O'Connell MJ, Jaquish TJ, Palko RK, Mantz CJ, Anand D, Lovicu FJ, Lachke SA, Robinson ML. Lens Epithelial Explants Treated with Vitreous Humor Undergo Alterations in Chromatin Landscape with Concurrent Activation of Genes Associated with Fiber Cell Differentiation and Innate Immune Response. Cells. 12. PMID 36766843 DOI: 10.3390/cells12030501  0.448
2022 Patel SD, Anand D, Motohashi H, Katsuoka F, Yamamoto M, Lachke SA. Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects. Frontiers in Cell and Developmental Biology. 10: 981893. PMID 36092713 DOI: 10.3389/fcell.2022.981893  0.428
2021 Lachke SA. RNA-binding proteins and post-transcriptional regulation in lens biology and cataract: Mediating spatiotemporal expression of key factors that control the cell cycle, transcription, cytoskeleton and transparency. Experimental Eye Research. 214: 108889. PMID 34906599 DOI: 10.1016/j.exer.2021.108889  0.482
2021 Rowan S, Jiang S, Francisco SG, Pomatto LCD, Ma Z, Jiao X, Campos MM, Aryal S, Patel SD, Mahaling B, Riazuddin SA, Duh EJ, Lachke SA, Hejtmancik JF, de Cabo R, et al. Aged Nrf2-Null Mice Develop All Major Types of Age-Related Cataracts. Investigative Ophthalmology & Visual Science. 62: 10. PMID 34882206 DOI: 10.1167/iovs.62.15.10  0.577
2021 Blizzard LE, Menke C, Patel SD, Waclaw RR, Lachke SA, Stottmann RW. A Novel Mutation in Cse1l Disrupts Brain and Eye Development with Specific Effects on Pax6 Expression. Journal of Developmental Biology. 9. PMID 34287339 DOI: 10.3390/jdb9030027  0.393
2021 Choquet H, Melles RB, Anand D, Yin J, Cuellar-Partida G, Wang W, Hoffmann TJ, Nair KS, Hysi PG, Lachke SA, Jorgenson E. A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects. Nature Communications. 12: 3595. PMID 34127677 DOI: 10.1038/s41467-021-23873-8  0.339
2021 Anand D, Al Saai S, Shrestha SK, Barnum CE, Chuma S, Lachke SA. Genome-Wide Analysis of Differentially Expressed miRNAs and Their Associated Regulatory Networks in Lenses Deficient for the Congenital Cataract-Linked Tudor Domain Containing Protein TDRD7. Frontiers in Cell and Developmental Biology. 9: 615761. PMID 33665188 DOI: 10.3389/fcell.2021.615761  0.755
2020 Aryal S, Viet J, Weatherbee BAT, Siddam AD, Hernandez FG, Gautier-Courteille C, Paillard L, Lachke SA. The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development. Human Genetics. PMID 32594240 DOI: 10.1007/S00439-020-02195-7  0.836
2020 Barnum CE, Al Saai S, Patel SD, Cheng C, Anand D, Xu X, Dash S, Siddam AD, Glazewski L, Paglione E, Polson SW, Chuma S, Mason RW, Wei S, Batish M, ... ... Lachke SA, et al. The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology. Human Molecular Genetics. PMID 32420594 DOI: 10.1093/Hmg/Ddaa096  0.769
2019 Viet J, Reboutier D, Hardy S, Lachke SA, Paillard L, Gautier-Courteille C. Modeling ocular lens disease in Xenopus. Developmental Dynamics : An Official Publication of the American Association of Anatomists. PMID 31872467 DOI: 10.1002/Dvdy.147  0.34
2019 Dash S, Brastrom LK, Patel SD, Scott CA, Slusarski DC, Lachke SA. The master transcription factor SOX2, mutated in anophthalmia/microphthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development. Human Molecular Genetics. PMID 31814023 DOI: 10.1093/Hmg/Ddz278  0.829
2019 Aryal S, Anand D, Hernandez FG, Weatherbee BAT, Huang H, Reddy AP, Wilmarth PA, David LL, Lachke SA. MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract. Human Genetics. PMID 31797049 DOI: 10.1007/S00439-019-02095-5  0.692
2019 Sweat YY, Sweat M, Mansaray M, Cao H, Eliason S, Adeyemo WL, Gowans LJJ, Eshete MA, Anand D, Chalkley C, Saadi I, Lachke SA, Butali A, Amendt BA. Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation. Developmental Biology. PMID 31765609 DOI: 10.1016/J.Ydbio.2019.11.010  0.496
2019 Padula SL, Anand D, Hoang TV, Chaffee BR, Liu L, Liang C, Lachke SA, Robinson ML. High-throughput transcriptome analysis reveals that the loss of Pten activates a novel NKX6-1/RASGRP1 regulatory module to rescue microphthalmia caused by Fgfr2-deficient lenses. Human Genetics. PMID 31691004 DOI: 10.1007/S00439-019-02084-8  0.493
2019 Weatherbee BAT, Barton JR, Siddam AD, Anand D, Lachke SA. Molecular characterization of the human lens epithelium-derived cell line SRA01/04. Experimental Eye Research. 188: 107787. PMID 31479653 DOI: 10.1016/J.Exer.2019.107787  0.828
2019 Cox TC, Lidral AC, McCoy JC, Liu H, Cox LL, Zhu Y, Anderson RD, Moreno Uribe LM, Anand D, Deng M, Richter CT, Nidey NL, Standley JM, Blue EE, Chong JX, ... ... Lachke SA, et al. Mutations in GDF11 and the extracellular antagonist, Follistatin, as a likely cause of Mendelian forms of orofacial clefting in humans. Human Mutation. PMID 31215115 DOI: 10.1002/Humu.23793  0.364
2019 Carlson JC, Anand D, Butali A, Buxo CJ, Christensen K, Deleyiannis F, Hecht JT, Moreno LM, Orioli IM, Padilla C, Shaffer JR, Vieira AR, Wehby GL, Weinberg SM, Murray JC, ... ... Lachke SA, et al. A systematic genetic analysis and visualization of phenotypic heterogeneity among orofacial cleft GWAS signals. Genetic Epidemiology. PMID 31172578 DOI: 10.1002/Gepi.22214  0.32
2019 Lachke S. iSyTE: A web resource tool to expedite eye gene discovery Acta Ophthalmologica. 97. DOI: 10.1111/J.1755-3768.2019.5007  0.428
2018 Butali A, Mossey PA, Adeyemo WL, Eshete MA, Gowans LJJ, Busch TD, Jain D, Yu W, Huan L, Laurie CA, Laurie CC, Nelson S, Li M, Sanchez-Lara PA, Magee WP, ... ... Lachke SA, et al. Genomic analyses in african populations identify novel risk loci for cleft palate. Human Molecular Genetics. PMID 30452639 DOI: 10.1093/Hmg/Ddy402  0.311
2018 Anand D, Kakrana A, Siddam AD, Huang H, Saadi I, Lachke SA. RNA sequencing-based transcriptomic profiles of embryonic lens development for cataract gene discovery. Human Genetics. PMID 30417254 DOI: 10.1007/S00439-018-1958-0  0.838
2018 Cox LL, Cox TC, Moreno Uribe LM, Zhu Y, Richter CT, Nidey N, Standley JM, Deng M, Blue E, Chong JX, Yang Y, Carstens RP, Anand D, Lachke SA, Smith JD, et al. Mutations in the Epithelial Cadherin-p120-Catenin Complex Cause Mendelian Non-Syndromic Cleft Lip with or without Cleft Palate. American Journal of Human Genetics. PMID 29805042 DOI: 10.1016/J.Ajhg.2018.04.009  0.394
2018 Krall M, Htun S, Anand D, Hart D, Lachke SA, Slavotinek AM. A zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans. Human Genetics. PMID 29713869 DOI: 10.1007/S00439-018-1884-1  0.6
2018 Siddam AD, Gautier-Courteille C, Perez-Campos L, Anand D, Kakrana A, Dang CA, Legagneux V, Méreau A, Viet J, Gross JM, Paillard L, Lachke SA. The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development. Plos Genetics. 14: e1007278. PMID 29565969 DOI: 10.1371/Journal.Pgen.1007278  0.833
2018 Budak G, Dash S, Srivastava R, Lachke SA, Janga SC. Express: A database of transcriptome profiles encompassing known and novel transcripts across multiple development stages in eye tissues. Experimental Eye Research. PMID 29337142 DOI: 10.1016/J.Exer.2018.01.009  0.838
2018 Anand D, Agrawal SA, Slavotinek A, Lachke SA. Mutation update of transcription factor genes FOXE3, HSF4, MAF and PITX3 causing cataracts and other developmental ocular defects. Human Mutation. PMID 29314435 DOI: 10.1002/Humu.23395  0.755
2017 Kakrana A, Yang A, Anand D, Djordjevic D, Ramachandruni D, Singh A, Huang H, Ho JWK, Lachke SA. iSyTE 2.0: a database for expression-based gene discovery in the eye. Nucleic Acids Research. PMID 29036527 DOI: 10.1093/Nar/Gkx837  0.507
2017 Srivastava R, Budak G, Dash S, Lachke SA, Janga SC. Transcriptome analysis of developing lens reveals abundance of novel transcripts and extensive splicing alterations. Scientific Reports. 7: 11572. PMID 28912564 DOI: 10.1038/S41598-017-10615-4  0.83
2017 Cavalheiro GR, Matos-Rodrigues GE, Zhao Y, Gomes AL, Anand D, Predes D, de Lima S, Abreu JG, Zheng D, Lachke SA, Cvekl A, Martins RAP. N-myc regulates growth and fiber cell differentiation in lens development. Developmental Biology. PMID 28716713 DOI: 10.1016/J.Ydbio.2017.07.002  0.492
2016 Patel N, Anand D, Monies D, Maddirevula S, Khan AO, Algoufi T, Alowain M, Faqeih E, Alshammari M, Qudair A, Alsharif H, Aljubran F, Alsaif HS, Ibrahim N, Abdulwahab FM, ... ... Lachke SA, et al. Novel phenotypes and loci identified through clinical genomics approaches to pediatric cataract. Human Genetics. PMID 27878435 DOI: 10.1007/S00439-016-1747-6  0.377
2016 Dash S, Siddam AD, Barnum CE, Janga SC, Lachke SA. RNA-binding proteins in eye development and disease: implication of conserved RNA granule components. Wiley Interdisciplinary Reviews. Rna. PMID 27133484 DOI: 10.1002/Wrna.1355  0.778
2016 Anand D, Lachke SA. Systems biology of lens development: A paradigm for disease gene discovery in the eye. Experimental Eye Research. PMID 26992779 DOI: 10.1016/J.Exer.2016.03.010  0.543
2016 Audette DS, Anand D, So T, Rubenstein TB, Lachke SA, Lovicu FJ, Duncan MK. Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression. Development (Cambridge, England). 143: 318-28. PMID 26657765 DOI: 10.1242/Dev.127860  0.48
2015 Zhang Y, Fan J, Ho JW, Hu T, Kneeland SC, Fan X, Xi Q, Sellarole MA, de Vries WN, Lu W, Lachke SA, Lang RA, John SW, Maas RL. Crim1 regulates integrin signaling in murine lens development. Development (Cambridge, England). PMID 26681494 DOI: 10.1242/Dev.125591  0.652
2015 Anand D, Agrawal S, Siddam A, Motohashi H, Yamamoto M, Lachke SA. An integrative approach to analyze microarray datasets for prioritization of genes relevant to lens biology and disease. Genomics Data. 5: 223-227. PMID 26185746 DOI: 10.1016/J.Gdata.2015.06.017  0.807
2015 Dash S, Dang CA, Beebe DC, Lachke SA. Deficiency of the RNA binding protein caprin2 causes lens defects and features of peters anomaly. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 244: 1313-27. PMID 26177727 DOI: 10.1002/Dvdy.24303  0.827
2015 Siddam AD, Gautier-Courteille C, Kakrana A, Legagneux V, Dang CA, Perez-Campos L, Méreau A, Scheiblin D, Viet J, Beebe DC, Gross JM, Paillard L, Lachke SA. 90 Focus on a clear message: conserved RNA binding proteins function in mRNA control in eye lens development and their deficiency causes cataract. Journal of Biomolecular Structure & Dynamics. 33: 58-9. PMID 26103300 DOI: 10.1080/07391102.2015.1032707  0.821
2015 Agrawal SA, Anand D, Siddam AD, Kakrana A, Dash S, Scheiblin DA, Dang CA, Terrell AM, Waters SM, Singh A, Motohashi H, Yamamoto M, Lachke SA. Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of non-crystallin genes associated with cataract. Human Genetics. 134: 717-35. PMID 25896808 DOI: 10.1007/S00439-015-1554-5  0.803
2015 Terrell AM, Anand D, Smith SF, Dang CA, Waters SM, Pathania M, Beebe DC, Lachke SA. Molecular characterization of mouse lens epithelial cell lines and their suitability to study RNA granules and cataract associated genes. Experimental Eye Research. 131: 42-55. PMID 25530357 DOI: 10.1016/J.Exer.2014.12.011  0.561
2015 Dash S, Dang CA, Beebe DC, Lachke SA. Deficiency of the RNA binding protein caprin2 causes lens defects and features of peters anomaly Developmental Dynamics. DOI: 10.1002/dvdy.24303  0.775
2014 Anchan RM, Lachke SA, Gerami-Naini B, Lindsey J, Ng N, Naber C, Nickerson M, Cavallesco R, Rowan S, Eaton JL, Xi Q, Maas RL. Pax6- and Six3-mediated induction of lens cell fate in mouse and human ES cells. Plos One. 9: e115106. PMID 25517354 DOI: 10.1371/Journal.Pone.0115106  0.649
2014 Manthey AL, Terrell AM, Lachke SA, Polson SW, Duncan MK. Development of novel filtering criteria to analyze RNA-sequencing data obtained from the murine ocular lens during embryogenesis. Genomics Data. 2: 369-374. PMID 25478318 DOI: 10.1016/J.Gdata.2014.10.015  0.556
2014 Manthey AL, Lachke SA, FitzGerald PG, Mason RW, Scheiblin DA, McDonald JH, Duncan MK. Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development. Mechanisms of Development. 131: 86-110. PMID 24161570 DOI: 10.1016/J.Mod.2013.09.005  0.582
2013 Wolf L, Harrison W, Huang J, Xie Q, Xiao N, Sun J, Kong L, Lachke SA, Kuracha MR, Govindarajan V, Brindle PK, Ashery-Padan R, Beebe DC, Overbeek PA, Cvekl A. Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. Nucleic Acids Research. 41: 10199-214. PMID 24038357 DOI: 10.1093/Nar/Gkt824  0.372
2012 Jumlongras D, Lachke SA, O'Connell DJ, Aboukhalil A, Li X, Choe SE, Ho JW, Turbe-Doan A, Robertson EA, Olsen BR, Bulyk ML, Amendt BA, Maas RL. An evolutionarily conserved enhancer regulates Bmp4 expression in developing incisor and limb bud. Plos One. 7: e38568. PMID 22701669 DOI: 10.1371/Journal.Pone.0038568  0.67
2012 Lachke SA, Ho JW, Kryukov GV, O'Connell DJ, Aboukhalil A, Bulyk ML, Park PJ, Maas RL. iSyTE: integrated Systems Tool for Eye gene discovery. Investigative Ophthalmology & Visual Science. 53: 1617-27. PMID 22323457 DOI: 10.1167/Iovs.11-8839  0.707
2012 Lachke SA, Higgins AW, Inagaki M, Saadi I, Xi Q, Long M, Quade BJ, Talkowski ME, Gusella JF, Fujimoto A, Robinson ML, Yang Y, Duong QT, Shapira I, Motro B, et al. The cell adhesion gene PVRL3 is associated with congenital ocular defects. Human Genetics. 131: 235-50. PMID 21769484 DOI: 10.1007/S00439-011-1064-Z  0.659
2011 Lachke SA, Maas RL. RNA Granules and Cataract. Expert Review of Ophthalmology. 6: 497-500. PMID 23847690 DOI: 10.1586/Eop.11.53  0.626
2011 Kasaikina MV, Fomenko DE, Labunskyy VM, Lachke SA, Qiu W, Moncaster JA, Zhang J, Wojnarowicz MW, Natarajan SK, Malinouski M, Schweizer U, Tsuji PA, Carlson BA, Maas RL, Lou MF, et al. Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice. The Journal of Biological Chemistry. 286: 33203-12. PMID 21768092 DOI: 10.1074/Jbc.M111.259218  0.627
2011 Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai AC, Nair KS, Cosma MI, Smith RS, Hodges E, Alfadhli SM, et al. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science (New York, N.Y.). 331: 1571-6. PMID 21436445 DOI: 10.1126/Science.1195970  0.74
2010 Lachke SA, Maas RL. Building the developmental oculome: systems biology in vertebrate eye development and disease. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 2: 305-23. PMID 20836031 DOI: 10.1002/Wsbm.59  0.655
2010 Rowan S, Siggers T, Lachke SA, Yue Y, Bulyk ML, Maas RL. Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity. Genes & Development. 24: 980-5. PMID 20413611 DOI: 10.1101/Gad.1890410  0.665
2009 Rowan S, Siggers T, Lachke S, Bulyk ML, Maas RL. Prep1 regulates lens induction via direct regulation of the Pax6 ectodermal enhancer Developmental Biology. 331: 440-441. DOI: 10.1016/J.Ydbio.2009.05.199  0.618
2008 Burdon KP, Hattersley K, Lachke SA, Laurie KJ, Maas RL, Mackey DA, Craig JE. Investigation of eight candidate genes on chromosome 1p36 for autosomal dominant total congenital cataract. Molecular Vision. 14: 1799-804. PMID 18843385  0.55
2006 Donner AL, Lachke SA, Maas RL. Lens induction in vertebrates: variations on a conserved theme of signaling events. Seminars in Cell & Developmental Biology. 17: 676-85. PMID 17164096 DOI: 10.1016/J.Semcdb.2006.10.005  0.591
2003 Brockert PJ, Lachke SA, Srikantha T, Pujol C, Galask R, Soll DR. Phenotypic switching and mating type switching of Candida glabrata at sites of colonization. Infection and Immunity. 71: 7109-18. PMID 14638801 DOI: 10.1128/Iai.71.12.7109-7118.2003  0.487
2003 Lachke SA, Lockhart SR, Daniels KJ, Soll DR. Skin facilitates Candida albicans mating. Infection and Immunity. 71: 4970-6. PMID 12933839 DOI: 10.1128/Iai.71.9.4970-4976.2003  0.489
2003 Srikantha T, Lachke SA, Soll DR. Three mating type-like loci in Candida glabrata. Eukaryotic Cell. 2: 328-40. PMID 12684382 DOI: 10.1128/Ec.2.2.328-340.2003  0.527
2003 Lachke SA, Srikantha T, Soll DR. The regulation of EFG1 in white-opaque switching in Candida albicans involves overlapping promoters. Molecular Microbiology. 48: 523-36. PMID 12675809 DOI: 10.1046/J.1365-2958.2003.T01-1-03448.X  0.54
2002 Lachke SA, Joly S, Daniels K, Soll DR. Phenotypic switching and filamentation in Candida glabrata. Microbiology (Reading, England). 148: 2661-74. PMID 12213913 DOI: 10.1099/00221287-148-9-2661  0.527
2000 Lachke SA, Srikantha T, Tsai LK, Daniels K, Soll DR. Phenotypic switching in Candida glabrata involves phase-specific regulation of the metallothionein gene MT-II and the newly discovered hemolysin gene HLP. Infection and Immunity. 68: 884-95. PMID 10639459 DOI: 10.1128/Iai.68.2.884-895.2000  0.585
1999 Kvaal C, Lachke SA, Srikantha T, Daniels K, McCoy J, Soll DR. Misexpression of the opaque-phase-specific gene PEP1 (SAP1) in the white phase of Candida albicans confers increased virulence in a mouse model of cutaneous infection. Infection and Immunity. 67: 6652-62. PMID 10569787 DOI: 10.1128/Iai.67.12.6652-6662.1999  0.503
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