| Year |
Citation |
Score |
| 2023 |
Codocedo JF, Mera-Reina C, Lin PB, Puntambekar SS, Casali BT, Jury N, Martinez P, Lasagna-Reeves CA, Landreth GE. Therapeutic targeting of immunometabolism in Alzheimer's disease reveals a critical reliance on Hexokinase 2 dosage on microglial activation and disease progression. Biorxiv : the Preprint Server For Biology. PMID 38014106 DOI: 10.1101/2023.11.11.566270 |
0.467 |
|
| 2023 |
Zhang P, Ma D, Cheng X, Tsai AP, Tang Y, Gao HC, Fang L, Bi C, Landreth GE, Chubykin AA, Huang F. Deep learning-driven adaptive optics for single-molecule localization microscopy. Nature Methods. PMID 37770712 DOI: 10.1038/s41592-023-02029-0 |
0.559 |
|
| 2023 |
Tsai AP, Dong C, Lin PB, Oblak AL, Viana Di Prisco G, Wang N, Hajicek N, Carr AJ, Lendy EK, Hahn O, Atkins M, Foltz AG, Patel J, Xu G, Moutinho M, ... ... Landreth GE, et al. Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease. Immunity. PMID 37659412 DOI: 10.1016/j.immuni.2023.08.008 |
0.782 |
|
| 2023 |
Wyatt-Johnson SK, Kersey HN, Codocedo JF, Newell KL, Landreth GE, Lamb BT, Oblak AL, Brutkiewicz RR. Control of the temporal development of Alzheimer's disease pathology by the MR1/MAIT cell axis. Journal of Neuroinflammation. 20: 78. PMID 36944969 DOI: 10.1186/s12974-023-02761-6 |
0.366 |
|
| 2023 |
Moutinho M, Coronel I, Tsai AP, Di Prisco GV, Pennington T, Atwood BK, Puntambekar SS, Smith DC, Martinez P, Han S, Lee Y, Lasagna-Reeves CA, Lamb BT, Bissel SJ, Nho K, ... Landreth GE, et al. TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation. Genome Medicine. 15: 11. PMID 36805764 DOI: 10.1186/s13073-023-01160-z |
0.717 |
|
| 2022 |
Lin PB, Tsai AP, Soni D, Lee-Gosselin A, Moutinho M, Puntambekar SS, Landreth GE, Lamb BT, Oblak AL. INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36524682 DOI: 10.1002/alz.12849 |
0.754 |
|
| 2022 |
Wang N, Maharjan S, Tsai AP, Lin PB, Qi Y, Wallace A, Jewett M, Liu F, Landreth GE, Oblak AL. Integrating Multimodality MRI to Allen Mouse Brain Common Coordinate Framework (CCFv3). Nmr in Biomedicine. e4887. PMID 36454009 DOI: 10.1002/nbm.4887 |
0.579 |
|
| 2022 |
Martinez P, Patel H, You Y, Jury N, Perkins A, Lee-Gosselin A, Taylor X, You Y, Viana Di Prisco G, Huang X, Dutta S, Wijeratne AB, Redding-Ochoa J, Shahid SS, Codocedo JF, ... ... Landreth GE, et al. Bassoon contributes to tau-seed propagation and neurotoxicity. Nature Neuroscience. PMID 36344699 DOI: 10.1038/s41593-022-01191-6 |
0.317 |
|
| 2022 |
Maharjan S, Tsai AP, Lin PB, Ingraham C, Jewett MR, Landreth GE, Oblak AL, Wang N. Corrigendum: Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging. Frontiers in Neuroscience. 16: 1025457. PMID 36312018 DOI: 10.3389/fnins.2022.1025457 |
0.573 |
|
| 2022 |
Maharjan S, Tsai AP, Lin PB, Ingraham C, Jewett MR, Landreth GE, Oblak AL, Wang N. Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging. Frontiers in Neuroscience. 16: 964654. PMID 36061588 DOI: 10.3389/fnins.2022.964654 |
0.571 |
|
| 2022 |
Puntambekar SS, Moutinho M, Lin PB, Jadhav V, Tumbleson-Brink D, Balaji A, Benito MA, Xu G, Oblak A, Lasagna-Reeves CA, Landreth GE, Lamb BT. CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer's disease. Molecular Neurodegeneration. 17: 47. PMID 35764973 DOI: 10.1186/s13024-022-00545-9 |
0.446 |
|
| 2022 |
Moutinho M, Puntambekar SS, Tsai AP, Coronel I, Lin PB, Casali BT, Martinez P, Oblak AL, Lasagna-Reeves CA, Lamb BT, Landreth GE. The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease. Science Translational Medicine. 14: eabl7634. PMID 35320002 DOI: 10.1126/scitranslmed.abl7634 |
0.753 |
|
| 2022 |
Tsai AP, Dong C, Lin PB, Messenger EJ, Casali BT, Moutinho M, Liu Y, Oblak AL, Lamb BT, Landreth GE, Bissel SJ, Nho K. PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer's disease. Genome Medicine. 14: 17. PMID 35180881 DOI: 10.1186/s13073-022-01022-0 |
0.743 |
|
| 2022 |
Claes C, England WE, Danhash EP, Kiani Shabestari S, Jairaman A, Chadarevian JP, Hasselmann J, Tsai AP, Coburn MA, Sanchez J, Lim TE, Hidalgo JLS, Tu C, Cahalan MD, Lamb BT, ... Landreth GE, et al. The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35142046 DOI: 10.1002/alz.12577 |
0.716 |
|
| 2021 |
Tsai AP, Lin PB, Dong C, Moutinho M, Casali BT, Liu Y, Lamb BT, Landreth GE, Oblak AL, Nho K. INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia. Neurobiology of Disease. 105303. PMID 33631273 DOI: 10.1016/j.nbd.2021.105303 |
0.741 |
|
| 2020 |
Jadhav VS, Lin PBC, Pennington T, Di Prisco GV, Jannu AJ, Xu G, Moutinho M, Zhang J, Atwood BK, Puntambekar SS, Bissel SJ, Oblak AL, Landreth GE, Lamb BT. Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice. Molecular Neurodegeneration. 15: 62. PMID 33115519 DOI: 10.1186/s13024-020-00409-0 |
0.697 |
|
| 2020 |
von Saucken VE, Jay TR, Landreth GE. The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's disease. Neurobiology of Disease. 105072. PMID 32890775 DOI: 10.1016/j.nbd.2020.105072 |
0.483 |
|
| 2020 |
Casali BT, MacPherson KP, Reed-Geaghan EG, Landreth GE. Microglia depletion rapidly and reversibly alters amyloid pathology by modification of plaque compaction and morphologies. Neurobiology of Disease. 104956. PMID 32479996 DOI: 10.1016/j.nbd.2020.104956 |
0.838 |
|
| 2020 |
Reed-Geaghan EG, Croxford AL, Becher B, Landreth GE. Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model. The Journal of Experimental Medicine. 217. PMID 31967645 DOI: 10.1084/jem.20191374 |
0.828 |
|
| 2019 |
Jay TR, von Saucken VE, Muñoz B, Codocedo JF, Atwood BK, Lamb BT, Landreth GE. TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment. Glia. PMID 31265185 DOI: 10.1002/Glia.23664 |
0.572 |
|
| 2019 |
Mlodzianoski M, Cheng-Hathaway P, Liu S, Bemiller S, McCray T, Miller D, Lamb B, Landreth G, Huang F. Active PSF Shaping and Adaptive Optics Enable Volumetric Single Molecule Super-Resolution Microscopy through Brain Sections Biophysical Journal. 116: 283a-284a. DOI: 10.1016/J.Bpj.2018.11.1533 |
0.558 |
|
| 2018 |
Konttinen H, Gureviciene I, Oksanen M, Grubman A, Loppi S, Huuskonen MT, Korhonen P, Lampinen R, Keuters M, Belaya I, Tanila H, Kanninen KM, Goldsteins G, Landreth G, Koistinaho J, et al. PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes. Glia. PMID 30453390 DOI: 10.1002/Glia.23534 |
0.458 |
|
| 2018 |
Vithayathil J, Pucilowska J, Landreth GE. ERK/MAPK signaling and autism spectrum disorders. Progress in Brain Research. 241: 63-112. PMID 30447757 DOI: 10.1016/Bs.Pbr.2018.09.008 |
0.631 |
|
| 2018 |
Loppi S, Kolosowska N, Kärkkäinen O, Korhonen P, Huuskonen M, Grubman A, Dhungana H, Wojciechowski S, Pomeshchik Y, Giordano M, Kagechika H, White A, Auriola S, Koistinaho J, Landreth G, et al. HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage. Brain, Behavior, and Immunity. PMID 30063972 DOI: 10.1016/J.Bbi.2018.07.021 |
0.313 |
|
| 2018 |
Mlodzianoski MJ, Cheng-Hathaway PJ, Bemiller SM, McCray TJ, Liu S, Miller DA, Lamb BT, Landreth GE, Huang F. Active PSF shaping and adaptive optics enable volumetric localization microscopy through brain sections. Nature Methods. PMID 30013047 DOI: 10.1038/S41592-018-0053-8 |
0.576 |
|
| 2018 |
Pucilowska J, Vithayathil J, Pagani M, Kelly C, Karlo JC, Robol C, Morella I, Gozzi A, Brambilla R, Landreth GE. Pharmacological Inhibition of ERK Signaling Rescues Pathophysiology and Behavioral Phenotype Associated with 16p11.2 Chromosomal Deletion in Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29934348 DOI: 10.1523/Jneurosci.0515-17.2018 |
0.657 |
|
| 2018 |
Cheng-Hathaway PJ, Reed-Geaghan EG, Jay TR, Casali BT, Bemiller SM, Puntambekar SS, von Saucken VE, Williams RY, Karlo JC, Moutinho M, Xu G, Ransohoff RM, Lamb BT, Landreth GE. The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease. Molecular Neurodegeneration. 13: 29. PMID 29859094 DOI: 10.1186/S13024-018-0262-8 |
0.827 |
|
| 2018 |
Casali BT, Reed-Geaghan EG, Landreth GE. Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer's disease. Journal of Neuroinflammation. 15: 43. PMID 29448961 DOI: 10.1186/s12974-018-1091-y |
0.825 |
|
| 2017 |
Ardura-Fabregat A, Boddeke EWGM, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzériat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, ... Landreth G, et al. Targeting Neuroinflammation to Treat Alzheimer's Disease. Cns Drugs. PMID 29260466 DOI: 10.1007/S40263-017-0483-3 |
0.512 |
|
| 2017 |
Bemiller SM, McCray TJ, Allan K, Formica SV, Xu G, Wilson G, Kokiko-Cochran ON, Crish SD, Lasagna-Reeves CA, Ransohoff RM, Landreth GE, Lamb BT. TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy. Molecular Neurodegeneration. 12: 74. PMID 29037207 DOI: 10.1186/S13024-017-0216-6 |
0.713 |
|
| 2017 |
Vithayathil J, Pucilowska J, Friel D, Landreth GE. Chronic impairment of ERK signaling in glutamatergic neurons of the forebrain does not affect spatial memory retention and LTP in the same manner as acute blockade of the ERK pathway. Hippocampus. PMID 28833860 DOI: 10.1002/Hipo.22769 |
0.638 |
|
| 2017 |
Jay TR, von Saucken VE, Landreth GE. TREM2 in Neurodegenerative Diseases. Molecular Neurodegeneration. 12: 56. PMID 28768545 DOI: 10.1186/s13024-017-0197-5 |
0.365 |
|
| 2017 |
Mast N, Saadane A, Valencia-Olvera A, Constans J, Maxfield E, Arakawa H, Li Y, Landreth G, Pikuleva IA. Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease. Neuropharmacology. PMID 28655608 DOI: 10.1016/J.Neuropharm.2017.06.026 |
0.453 |
|
| 2017 |
Moutinho M, Landreth GE. Therapeutic potential of nuclear receptor agonists in Alzheimer's disease. Journal of Lipid Research. PMID 28264880 DOI: 10.1194/jlr.R075556 |
0.447 |
|
| 2017 |
Mariani MM, Malm T, Lamb R, Jay TR, Neilson L, Casali B, Medarametla L, Landreth GE. Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease. Scientific Reports. 7: 42270. PMID 28205585 DOI: 10.1038/srep42270 |
0.319 |
|
| 2017 |
Piirainen S, Youssef A, Song C, Kalueff AV, Landreth GE, Malm T, Tian L. Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia? Neuroscience and Biobehavioral Reviews. PMID 28185874 DOI: 10.1016/j.neubiorev.2017.01.046 |
0.347 |
|
| 2017 |
Jay TR, Hirsch AM, Broihier ML, Miller CM, Neilson LE, Ransohoff RM, Lamb BT, Landreth GE. Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 37: 637-647. PMID 28100745 DOI: 10.1523/Jneurosci.2110-16.2016 |
0.723 |
|
| 2016 |
Jay TR, Hirsch AM, Broihier ML, Miller CM, Neilson LE, Ransohoff RM, Lamb BT, Landreth GE. Disease progression-dependent effects of TREM2 deficiency in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27940990 DOI: 10.1523/JNEUROSCI.2110-16.2016 |
0.723 |
|
| 2016 |
Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, et al. Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy. Scientific Reports. 6: 33176. PMID 27624652 DOI: 10.1038/Srep33176 |
0.331 |
|
| 2016 |
Heneka M, Andreasson KI, Bachstetter AD, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee DC, Low D, Lynch MA, Monsonego A, O'Banion MK, Pekny M, Puschmann T, et al. Targeting innate immunity for neurodegenerative disorders of the central nervous system. Journal of Neurochemistry. PMID 27248001 DOI: 10.1111/Jnc.13667 |
0.665 |
|
| 2016 |
Ostrowski SM, Johnson K, Siefert M, Shank S, Sironi L, Wolozin B, Landreth GE, Ziady AG. Simvastatin inhibits protein isoprenylation in the brain. Neuroscience. PMID 27180285 DOI: 10.1016/J.Neuroscience.2016.04.053 |
0.315 |
|
| 2016 |
Courtney R, Landreth GE. LXR Regulation of Brain Cholesterol: From Development to Disease. Trends in Endocrinology and Metabolism: Tem. PMID 27113081 DOI: 10.1016/j.tem.2016.03.018 |
0.332 |
|
| 2016 |
Riancho J, Berciano MT, Ruiz-Soto M, Berciano J, Landreth G, Lafarga M. Retinoids and motor neuron disease: Potential role in amyotrophic lateral sclerosis. Journal of the Neurological Sciences. 360: 115-20. PMID 26723986 DOI: 10.1016/J.Jns.2015.11.058 |
0.352 |
|
| 2016 |
Corona AW, Kodoma N, Casali BT, Landreth GE. ABCA1 is Necessary for Bexarotene-Mediated Clearance of Soluble Amyloid Beta from the Hippocampus of APP/PS1 Mice. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 11: 61-72. PMID 26175148 DOI: 10.1007/s11481-015-9627-8 |
0.405 |
|
| 2016 |
Jay T, Hirsch A, Broihier M, Landreth G. Trem2 deficiency is protective early but detrimental late in disease progression in an amyloid mouse model of Alzheimer's disease Neurobiology of Aging. 39. DOI: 10.1016/J.Neurobiolaging.2016.01.082 |
0.497 |
|
| 2016 |
Cheng-Hathaway P, Jay T, Reed E, Bemiller S, Puntambekar S, Xu G, Carlo C, Ransohoff R, Landreth G, Lamb BT. 02-07-06: The R47H Trem2 Variant Modifies Alzheimer's Disease Pathology and Neuroinflammation in a Novel Knock-In Mouse Model Alzheimer's & Dementia. 12: P243-P243. DOI: 10.1016/J.Jalz.2016.06.435 |
0.7 |
|
| 2016 |
Margolin RA, Schneider LS, Cutter GR, Breitner JC, Doody RS, Landreth G, Chain D. P3-012: Advancing Therapeutics for Neuroinflammation in Alzheimer's Disease: Clinical Development Considerations Alzheimer's & Dementia. 12: P822-P822. DOI: 10.1016/J.Jalz.2016.06.1669 |
0.426 |
|
| 2015 |
Corona A, Landreth G. Lipidated APOE has effects on cognitive function that are independent of amyloid-β pathology. Brain : a Journal of Neurology. 138: 3470-2. PMID 26598491 DOI: 10.1093/Brain/Awv300 |
0.411 |
|
| 2015 |
Jay T, Lamb B, Landreth G. Peripheral macrophages not ADept at amyloid clearance. The Journal of Experimental Medicine. 212: 1758. PMID 26482143 DOI: 10.1084/jem.21211insight5 |
0.609 |
|
| 2015 |
Skerrett R, Pellegrino MP, Casali BT, Taraboanta L, Landreth GE. Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice. The Journal of Biological Chemistry. 290: 21591-602. PMID 26163517 DOI: 10.1074/jbc.M115.652008 |
0.427 |
|
| 2015 |
Casali BT, Corona AW, Mariani MM, Karlo JC, Ghosal K, Landreth GE. Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9173-81. PMID 26085639 DOI: 10.1523/JNEUROSCI.1000-15.2015 |
0.455 |
|
| 2015 |
Vithayathil J, Pucilowska J, Goodnough LH, Atit RP, Landreth GE. Dentate Gyrus Development Requires ERK Activity to Maintain Progenitor Population and MAPK Pathway Feedback Regulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6836-48. PMID 25926459 DOI: 10.1523/JNEUROSCI.4196-14.2015 |
0.645 |
|
| 2015 |
Savage JC, Jay T, Goduni E, Quigley C, Mariani MM, Malm T, Ransohoff RM, Lamb BT, Landreth GE. Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6532-43. PMID 25904803 DOI: 10.1523/Jneurosci.4586-14.2015 |
0.708 |
|
| 2015 |
Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, et al. Neuroinflammation in Alzheimer's disease. The Lancet. Neurology. 14: 388-405. PMID 25792098 DOI: 10.1016/S1474-4422(15)70016-5 |
0.621 |
|
| 2015 |
Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, ... ... Landreth GE, et al. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. The Journal of Experimental Medicine. 212: 287-95. PMID 25732305 DOI: 10.1084/Jem.20142322 |
0.734 |
|
| 2015 |
Pucilowska J, Vithayathil J, Tavares EJ, Kelly C, Karlo JC, Landreth GE. The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 3190-200. PMID 25698753 DOI: 10.1523/Jneurosci.4864-13.2015 |
0.657 |
|
| 2015 |
Malm T, Mariani M, Donovan LJ, Neilson L, Landreth GE. Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation. Journal of Neuroinflammation. 12: 7. PMID 25592770 DOI: 10.1186/s12974-014-0229-9 |
0.484 |
|
| 2015 |
Malm TM, Jay TR, Landreth GE. The evolving biology of microglia in Alzheimer's disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 81-93. PMID 25404051 DOI: 10.1007/s13311-014-0316-8 |
0.47 |
|
| 2014 |
Lee S, Xu G, Jay TR, Bhatta S, Kim KW, Jung S, Landreth GE, Ransohoff RM, Lamb BT. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 12538-46. PMID 25209291 DOI: 10.1523/Jneurosci.0853-14.2014 |
0.692 |
|
| 2014 |
Skerrett R, Malm T, Landreth G. Nuclear receptors in neurodegenerative diseases. Neurobiology of Disease. 72: 104-16. PMID 24874548 DOI: 10.1016/J.Nbd.2014.05.019 |
0.45 |
|
| 2014 |
Bomben V, Holth J, Reed J, Cramer P, Landreth G, Noebels J. Bexarotene reduces network excitability in models of Alzheimer's disease and epilepsy. Neurobiology of Aging. 35: 2091-5. PMID 24767949 DOI: 10.1016/J.Neurobiolaging.2014.03.029 |
0.815 |
|
| 2014 |
Lamb B, Miller C, Jay T, Graham L, Bemiller S, Xu G, Margevicius D, Karlo C, Sousa G, Cotleur B, Bekris L, Staugaitis S, Leverenz J, Pimplikar SW, Landreth G, et al. P4-248: THE ROLE OF TREM2 EXPRESSION ON MYELOID CELLS IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P876-P877. DOI: 10.1016/J.Jalz.2014.07.019 |
0.676 |
|
| 2013 |
Wildsmith KR, Holley M, Savage JC, Skerrett R, Landreth GE. Evidence for impaired amyloid β clearance in Alzheimer's disease. Alzheimer's Research & Therapy. 5: 33. PMID 23849219 DOI: 10.1186/alzrt187 |
0.454 |
|
| 2013 |
Landreth GE, Cramer PE, Lakner MM, Cirrito JR, Wesson DW, Brunden KR, Wilson DA. Response to comments on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (New York, N.Y.). 340: 924-g. PMID 23704556 DOI: 10.1126/Science.1234114 |
0.782 |
|
| 2013 |
Ulrich JD, Burchett JM, Restivo JL, Schuler DR, Verghese PB, Mahan TE, Landreth GE, Castellano JM, Jiang H, Cirrito JR, Holtzman DM. In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis. Molecular Neurodegeneration. 8: 13. PMID 23601557 DOI: 10.1186/1750-1326-8-13 |
0.307 |
|
| 2012 |
Cameron B, Tse W, Lamb R, Li X, Lamb BT, Landreth GE. Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15112-23. PMID 23100432 DOI: 10.1523/Jneurosci.1729-12.2012 |
0.713 |
|
| 2012 |
Mandrekar-Colucci S, Karlo JC, Landreth GE. Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 10117-28. PMID 22836247 DOI: 10.1523/JNEUROSCI.5268-11.2012 |
0.476 |
|
| 2012 |
Pucilowska J, Puzerey PA, Karlo JC, Galán RF, Landreth GE. Disrupted ERK signaling during cortical development leads to abnormal progenitor proliferation, neuronal and network excitability and behavior, modeling human neuro-cardio-facial-cutaneous and related syndromes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8663-77. PMID 22723706 DOI: 10.1523/Jneurosci.1107-12.2012 |
0.662 |
|
| 2012 |
Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, Zinn AE, Casali BT, Restivo JL, Goebel WD, James MJ, Brunden KR, Wilson DA, Landreth GE. ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models. Science (New York, N.Y.). 335: 1503-6. PMID 22323736 DOI: 10.1126/Science.1217697 |
0.824 |
|
| 2012 |
Wilkinson BL, Cramer PE, Varvel NH, Reed-Geaghan E, Jiang Q, Szabo A, Herrup K, Lamb BT, Landreth GE. Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease. Neurobiology of Aging. 33: 197.e21-32. PMID 20696495 DOI: 10.1016/J.Neurobiolaging.2010.06.014 |
0.785 |
|
| 2012 |
Landreth G, Cramer P, Wesson D, Cirrito J, Brunden K, Wilson D. 44 ApoE-directed therapeutics for the treatment of Alzheimer's disease Neurobiology of Aging. 33: S19. DOI: 10.1016/J.Neurobiolaging.2012.01.062 |
0.813 |
|
| 2011 |
Mandrekar-Colucci S, Landreth GE. Nuclear receptors as therapeutic targets for Alzheimer's disease. Expert Opinion On Therapeutic Targets. 15: 1085-97. PMID 21718217 DOI: 10.1517/14728222.2011.594043 |
0.453 |
|
| 2011 |
Geldmacher DS, Fritsch T, McClendon MJ, Landreth G. A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease. Archives of Neurology. 68: 45-50. PMID 20837824 DOI: 10.1001/Archneurol.2010.229 |
0.367 |
|
| 2010 |
Portillo JA, Okenka G, Reed E, Subauste A, Van Grol J, Gentil K, Komatsu M, Tanaka K, Landreth G, Levine B, Subauste CS. The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels. Plos One. 5: e14472. PMID 21217818 DOI: 10.1371/Journal.Pone.0014472 |
0.303 |
|
| 2010 |
Reed-Geaghan EG, Reed QW, Cramer PE, Landreth GE. Deletion of CD14 attenuates Alzheimer's disease pathology by influencing the brain's inflammatory milieu. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15369-73. PMID 21084593 DOI: 10.1523/Jneurosci.2637-10.2010 |
0.8 |
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| 2010 |
Gold M, Alderton C, Zvartau-Hind M, Egginton S, Saunders AM, Irizarry M, Craft S, Landreth G, Linnamägi U, Sawchak S. Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study. Dementia and Geriatric Cognitive Disorders. 30: 131-46. PMID 20733306 DOI: 10.1159/000318845 |
0.43 |
|
| 2010 |
Lee CY, Landreth GE. The role of microglia in amyloid clearance from the AD brain. Journal of Neural Transmission (Vienna, Austria : 1996). 117: 949-60. PMID 20552234 DOI: 10.1007/s00702-010-0433-4 |
0.392 |
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| 2010 |
Mandrekar-Colucci S, Landreth GE. Microglia and inflammation in Alzheimer's disease. Cns & Neurological Disorders Drug Targets. 9: 156-67. PMID 20205644 |
0.452 |
|
| 2010 |
Cameron B, Landreth GE. Inflammation, microglia, and Alzheimer's disease. Neurobiology of Disease. 37: 503-9. PMID 19833208 DOI: 10.1016/j.nbd.2009.10.006 |
0.404 |
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| 2009 |
Reed-Geaghan EG, Savage JC, Hise AG, Landreth GE. CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 11982-92. PMID 19776284 DOI: 10.1523/JNEUROSCI.3158-09.2009 |
0.787 |
|
| 2009 |
Landreth GE, Reed-Geaghan EG. Toll-like receptors in Alzheimer's disease. Current Topics in Microbiology and Immunology. 336: 137-53. PMID 19688332 DOI: 10.1007/978-3-642-00549-7_8 |
0.825 |
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| 2009 |
Mandrekar S, Jiang Q, Lee CY, Koenigsknecht-Talboo J, Holtzman DM, Landreth GE. Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4252-62. PMID 19339619 DOI: 10.1523/Jneurosci.5572-08.2009 |
0.306 |
|
| 2009 |
Morgan D, Landreth G, Bickford P. The promise and perils of an Alzheimer disease vaccine: A video debate Journal of Neuroimmune Pharmacology. 4: 1-3. PMID 18946741 DOI: 10.1007/S11481-008-9132-4 |
0.488 |
|
| 2009 |
Cramer PE, Lee CD, Wilkinson BL, Landreth GE. P4-270: Retiniod X Receptor As A Therapeutic Target For Alzheimer's Disease Alzheimer's & Dementia. 5: e9-e9. DOI: 10.1016/J.Jalz.2009.07.051 |
0.791 |
|
| 2009 |
Gold M, Alderton C, Zvartau-Hind M, Ritchie S, Saunders A, Craft S, Landreth G, Linnamägi Ü, Sawchak S. Effects of rosiglitazone as monotherapy in APOE4-stratified subjects with mild-to-moderate Alzheimer's disease Alzheimers & Dementia. 5: 86. DOI: 10.1016/J.Jalz.2009.05.219 |
0.437 |
|
| 2009 |
Alderton C, Zvartau-Hind M, Ritchie S, Saunders A, Craft S, Landreth G, Linnamägi Ü, Sawchak S, Gold M. Secondary endpoint and responder analyses in a study of rosiglitazone XR in APOE4-stratified subjects with mild-to-moderate Alzheimer's disease Alzheimers & Dementia. 5: 254. DOI: 10.1016/J.Jalz.2009.04.271 |
0.435 |
|
| 2009 |
Zvartau-Hind M, Alderton C, Ritchie S, Saunders A, Irizarry M, Craft S, Landreth G, Linnamägi Ü, Sawchak S, Gold M. Safety and tolerability of rosiglitazone XR in a randomised, placebo-controlled study in APOE4-stratified subjects with mild-to-moderate Alzheimer's disease Alzheimers & Dementia. 5: 248. DOI: 10.1016/J.Jalz.2009.04.252 |
0.377 |
|
| 2008 |
Landreth G, Jiang Q, Mandrekar S, Heneka M. PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 5: 481-9. PMID 18625459 DOI: 10.1016/J.Nurt.2008.05.003 |
0.55 |
|
| 2008 |
Jiang Q, Lee CY, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, Mann K, Lamb B, Willson TM, Collins JL, Richardson JC, Smith JD, Comery TA, Riddell D, Holtzman DM, ... ... Landreth GE, et al. ApoE promotes the proteolytic degradation of Abeta. Neuron. 58: 681-93. PMID 18549781 DOI: 10.1016/J.Neuron.2008.04.010 |
0.807 |
|
| 2008 |
Jiang Q, Heneka M, Landreth GE. The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications. Cns Drugs. 22: 1-14. PMID 18072811 DOI: 10.2165/00023210-200822010-00001 |
0.463 |
|
| 2008 |
Landreth G. S1-03-02: Liver X Receptors act to facilitate Aβ clearance and suppress inflammation in the Alzheimer's disease brain Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.198 |
0.49 |
|
| 2008 |
Pucilowska J, Samuels I, Karlo C, Landreth G. [P2.33]: Simultaneous inactivation of Erk1 and Erk2 leads to perturbations in the control of the cell cycle during neurogenesis International Journal of Developmental Neuroscience. 26: 877-878. DOI: 10.1016/j.ijdevneu.2008.09.158 |
0.614 |
|
| 2007 |
Landreth G. The immunology of Alzheimer's disease: prospects towards harnessing disease mechanisms for therapeutic ends. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 2: 131-3. PMID 18040837 DOI: 10.1007/S11481-007-9067-1 |
0.441 |
|
| 2007 |
Heneka MT, Landreth GE, Hüll M. Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders. Nature Clinical Practice. Neurology. 3: 496-504. PMID 17805244 DOI: 10.1038/Ncpneuro0586 |
0.396 |
|
| 2007 |
Beekly DL, Ramos EM, Lee WW, Deitrich WD, Jacka ME, Wu J, Hubbard JL, Koepsell TD, Morris JC, Kukull WA, Reiman EM, Kowall N, Landreth G, Shelanski M, Welsh-Bohmer K, et al. The National Alzheimer's Coordinating Center (NACC) database: The uniform data set Alzheimer Disease and Associated Disorders. 21: 249-258. PMID 17804958 DOI: 10.1097/Wad.0B013E318142774E |
0.328 |
|
| 2007 |
Ostrowski SM, Wilkinson BL, Golde TE, Landreth G. Statins reduce amyloid-beta production through inhibition of protein isoprenylation. The Journal of Biological Chemistry. 282: 26832-44. PMID 17646164 DOI: 10.1074/Jbc.M702640200 |
0.421 |
|
| 2007 |
Heneka MT, Landreth GE. PPARs in the brain. Biochimica Et Biophysica Acta. 1771: 1031-45. PMID 17569578 DOI: 10.1016/J.Bbalip.2007.04.016 |
0.407 |
|
| 2007 |
Zelcer N, Khanlou N, Clare R, Jiang Q, Reed-Geaghan EG, Landreth GE, Vinters HV, Tontonoz P. Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proceedings of the National Academy of Sciences of the United States of America. 104: 10601-6. PMID 17563384 DOI: 10.1073/Pnas.0701096104 |
0.841 |
|
| 2007 |
Landreth G. Therapeutic use of agonists of the nuclear receptor PPARgamma in Alzheimer's disease. Current Alzheimer Research. 4: 159-64. PMID 17430241 DOI: 10.2174/156720507780362092 |
0.533 |
|
| 2006 |
Wilkinson BL, Landreth GE. The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease. Journal of Neuroinflammation. 3: 30. PMID 17094809 DOI: 10.1186/1742-2094-3-30 |
0.374 |
|
| 2006 |
Sundararajan S, Jiang Q, Heneka M, Landreth G. PPARgamma as a therapeutic target in central nervous system diseases. Neurochemistry International. 49: 136-44. PMID 16766086 DOI: 10.1016/J.Neuint.2006.03.020 |
0.425 |
|
| 2006 |
Landreth G. PPARgamma agonists as new therapeutic agents for the treatment of Alzheimer's disease. Experimental Neurology. 199: 245-8. PMID 16733054 DOI: 10.1016/J.Expneurol.2006.04.006 |
0.425 |
|
| 2006 |
Wilkinson B, Koenigsknecht-Talboo J, Grommes C, Lee CY, Landreth G. Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia. The Journal of Biological Chemistry. 281: 20842-50. PMID 16728400 DOI: 10.1074/Jbc.M600627200 |
0.4 |
|
| 2006 |
Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghgraef P, Evert BO, Dumitrescu-Ozimek L, Thal DR, Landreth G, Walter J, Klockgether T, van Leuven F, Heneka MT. Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proceedings of the National Academy of Sciences of the United States of America. 103: 443-8. PMID 16407166 DOI: 10.1073/Pnas.0503839103 |
0.419 |
|
| 2005 |
Koenigsknecht-Talboo J, Landreth GE. Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8240-9. PMID 16148231 DOI: 10.1523/JNEUROSCI.1808-05.2005 |
0.423 |
|
| 2005 |
Cordle A, Koenigsknecht-Talboo J, Wilkinson B, Limpert A, Landreth G. Mechanisms of statin-mediated inhibition of small G-protein function. The Journal of Biological Chemistry. 280: 34202-9. PMID 16085653 DOI: 10.1074/Jbc.M505268200 |
0.365 |
|
| 2005 |
Nekrasova T, Shive C, Gao Y, Kawamura K, Guardia R, Landreth G, Forsthuber TG. ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 175: 2374-80. PMID 16081808 DOI: 10.4049/Jimmunol.175.4.2374 |
0.307 |
|
| 2005 |
Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'Banion K, Klockgether T, Van Leuven F, Landreth GE. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain : a Journal of Neurology. 128: 1442-53. PMID 15817521 DOI: 10.1093/Brain/Awh452 |
0.406 |
|
| 2005 |
Cordle A, Landreth G. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 299-307. PMID 15647473 DOI: 10.1523/Jneurosci.2544-04.2005 |
0.456 |
|
| 2004 |
Koenigsknecht J, Landreth G. Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9838-46. PMID 15525768 DOI: 10.1523/Jneurosci.2557-04.2004 |
0.491 |
|
| 2004 |
Lacombe P, Mathews PM, Schmidt SD, Breidert T, Heneka MT, Landreth GE, Feinstein DL, Galea E. Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised. Journal of Neuroinflammation. 1: 11. PMID 15285804 DOI: 10.1186/1742-2094-1-11 |
0.315 |
|
| 2004 |
Dewachter I, Rosen E, Landreth G, Willson T, Klockgether T, Van Leuven F, Heneka M. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists modulate immunostimulated processing of APP through regulation of beta-secretase (BACE) Aktuelle Neurologie. 31. DOI: 10.1055/S-2004-833264 |
0.322 |
|
| 2003 |
Sastre M, Dewachter I, Landreth GE, Willson TM, Klockgether T, van Leuven F, Heneka MT. Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 9796-804. PMID 14586007 |
0.353 |
|
| 2003 |
Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G. Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7504-9. PMID 12930788 |
0.455 |
|
| 2003 |
Bamberger ME, Harris ME, McDonald DR, Husemann J, Landreth GE. A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 2665-74. PMID 12684452 |
0.313 |
|
| 2003 |
Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G. Anti-Inflammatory Drug Therapy Alters β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease The Journal of Neuroscience. 23: 7504-7509. DOI: 10.1523/Jneurosci.23-20-07504.2003 |
0.556 |
|
| 2002 |
Breidert T, Callebert J, Heneka MT, Landreth G, Launay JM, Hirsch EC. Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease. Journal of Neurochemistry. 82: 615-24. PMID 12153485 DOI: 10.1046/J.1471-4159.2002.00990.X |
0.344 |
|
| 2002 |
Zander T, Kraus JA, Grommes C, Schlegel U, Feinstein D, Klockgether T, Landreth G, Koenigsknecht J, Heneka MT. Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma. Journal of Neurochemistry. 81: 1052-60. PMID 12065618 DOI: 10.1046/J.1471-4159.2002.00899.X |
0.315 |
|
| 2002 |
Bamberger ME, Landreth GE. Inflammation, apoptosis, and Alzheimer's disease. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 8: 276-83. PMID 12061507 |
0.408 |
|
| 2001 |
Landreth GE, Heneka MT. Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease. Neurobiology of Aging. 22: 937-44. PMID 11755002 DOI: 10.1016/S0197-4580(01)00296-2 |
0.411 |
|
| 2001 |
Bamberger ME, Landreth GE. Microglial interaction with β-amyloid: Implications for the pathogenesis of Alzheimer's disease Microscopy Research and Technique. 54: 59-70. PMID 11455613 DOI: 10.1002/jemt.1121 |
0.481 |
|
| 2001 |
Heneka MT, Landreth GE, Feinstein DL. Role for peroxisome proliferator-activated receptor-gamma in Alzheimer's disease. Annals of Neurology. 49: 276. PMID 11220752 DOI: 10.1002/1531-8249(20010201)49:2<276::Aid-Ana53>3.0.Co;2-5 |
0.369 |
|
| 2000 |
Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, ... Landreth G, et al. Inflammation and Alzheimer's disease. Neurobiology of Aging. 21: 383-421. PMID 10858586 DOI: 10.1016/S0197-4580(00)00124-X |
0.682 |
|
| 2000 |
Combs CK, Johnson DE, Karlo JC, Cannady SB, Landreth GE. Inflammatory Mechanisms in Alzheimer's Disease: Inhibition of β-Amyloid-Stimulated Proinflammatory Responses and Neurotoxicity by PPARγ Agonists The Journal of Neuroscience. 20: 558-567. DOI: 10.1523/JNEUROSCI.20-02-00558.2000 |
0.364 |
|
| 1994 |
Myers MP, Murphy MB, Landreth G. The dual-specificity CLK kinase induces neuronal differentiation of PC12 cells. Molecular and Cellular Biology. 14: 6954-61. PMID 7935412 DOI: 10.1128/Mcb.14.10.6954 |
0.3 |
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