| Year |
Citation |
Score |
| 2022 |
Yu W, Moninger TO, Rector MV, Stoltz DA, Welsh MJ. Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction. Developmental Cell. 57: 2221-2236.e5. PMID 36108628 DOI: 10.1016/j.devcel.2022.08.010 |
0.532 |
|
| 2022 |
Thurman AL, Li X, Villacreses R, Yu W, Gong H, Mather SE, Romano-Ibarra GS, Meyerholz DK, Stoltz DA, Welsh MJ, Thornell IM, Zabner J, Pezzulo AA. A Single-Cell Atlas of Large and Small Airways at Birth in a Porcine Model of Cystic Fibrosis. American Journal of Respiratory Cell and Molecular Biology. PMID 35235762 DOI: 10.1165/rcmb.2021-0499OC |
0.555 |
|
| 2022 |
Yu W, Moninger TO, Thurman AL, Xie Y, Jain A, Zarei K, Powers LS, Pezzulo AA, Stoltz DA, Welsh MJ. Cellular and molecular architecture of submucosal glands in wild-type and cystic fibrosis pigs. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35046051 DOI: 10.1073/pnas.2119759119 |
0.567 |
|
| 2020 |
Xie Y, Lu L, Tang XX, Moninger TO, Huang TJ, Stoltz DA, Welsh MJ. Acidic Submucosal Gland pH and Elevated Protein Concentration Produce Abnormal Cystic Fibrosis Mucus. Developmental Cell. PMID 32730755 DOI: 10.1016/J.Devcel.2020.07.002 |
0.377 |
|
| 2020 |
Rehman T, Thornell IM, Pezzulo AA, Thurman AL, Romano Ibarra GS, Karp PH, Tan P, Duffey ME, Welsh MJ. TNFα and IL-17 Alkalinize Airway Surface Liquid through CFTR and Pendrin. American Journal of Physiology. Cell Physiology. PMID 32432926 DOI: 10.1152/Ajpcell.00112.2020 |
0.306 |
|
| 2019 |
Muraglia KA, Chorghade RS, Kim BR, Tang XX, Shah VS, Grillo AS, Daniels PN, Cioffi AG, Karp PH, Zhu L, Welsh MJ, Burke MD. Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia. Nature. PMID 30867598 DOI: 10.1038/S41586-019-1018-5 |
0.398 |
|
| 2018 |
Alaiwa MHA, Launspach JL, Grogan B, Carter S, Zabner J, Stoltz DA, Singh PK, McKone EF, Welsh MJ. Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis. Jci Insight. 3. PMID 30089726 DOI: 10.1172/Jci.Insight.121468 |
0.348 |
|
| 2018 |
Reznikov LR, Meyerholz DK, Abou Alaiwa MH, Kuan SP, Liao YJ, Bormann NL, Bair TB, Price M, Stoltz DA, Welsh MJ. The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 29631359 DOI: 10.1152/Ajplung.00557.2017 |
0.627 |
|
| 2018 |
Meyerholz DK, Stoltz DA, Gansemer ND, Ernst SE, Cook DP, Strub MD, LeClair EN, Barker CK, Adam RJ, Leidinger MR, Gibson-Corley KN, Karp PH, Welsh MJ, McCray PB. Lack of cystic fibrosis transmembrane conductance regulator disrupts fetal airway development in pigs. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 29467455 DOI: 10.1038/S41374-018-0026-7 |
0.337 |
|
| 2018 |
Mao S, Shah AS, Moninger TO, Ostedgaard LS, Lu L, Tang XX, Thornell IM, Reznikov LR, Ernst SE, Karp PH, Tan P, Keshavjee S, Abou Alaiwa MH, Welsh MJ. Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 29358407 DOI: 10.1073/Pnas.1719177115 |
0.733 |
|
| 2017 |
Du J, Price MP, Taugher RJ, Grigsby D, Ash JJ, Stark AC, Hossain Saad MZ, Singh K, Mandal J, Wemmie JA, Welsh MJ. Transient acidosis while retrieving a fear-related memory enhances its lability. Elife. 6. PMID 28650315 DOI: 10.7554/Elife.22564 |
0.726 |
|
| 2017 |
Adam RJ, Abou Alaiwa MH, Bouzek DC, Cook DP, Gansemer ND, Taft PJ, Powers LS, Stroik MR, Hoegger MJ, McMenimen JD, Hoffman EA, Zabner J, Welsh MJ, Meyerholz DK, Stoltz DA. Postnatal Airway Growth in Cystic Fibrosis Piglets. Journal of Applied Physiology (Bethesda, Md. : 1985). jap.00263.2017. PMID 28620056 DOI: 10.1152/Japplphysiol.00263.2017 |
0.333 |
|
| 2017 |
Ostedgaard LS, Moninger TO, McMenimen JD, Sawin NM, Parker CP, Thornell IM, Powers LS, Gansemer ND, Bouzek DC, Cook DP, Meyerholz DK, Abou Alaiwa MH, Stoltz DA, Welsh MJ. Gel-forming mucins form distinct morphologic structures in airways. Proceedings of the National Academy of Sciences of the United States of America. PMID 28607090 DOI: 10.1073/Pnas.1703228114 |
0.342 |
|
| 2017 |
Hisert KB, Heltshe SL, Pope C, Jorth P, Wu X, Edwards RM, Radey M, Accurso FJ, Wolter DJ, Cooke G, Adam RJ, Carter S, Grogan B, Launspach JL, Donnelly SC, ... ... Welsh MJ, et al. Restoring CFTR Function Reduces Airway Bacteria and Inflammation in People With Cystic Fibrosis and Chronic Lung Infections. American Journal of Respiratory and Critical Care Medicine. PMID 28222269 DOI: 10.1164/Rccm.201609-1954Oc |
0.312 |
|
| 2017 |
Du J, Price MP, Taugher RJ, Grigsby D, Ash JJ, Stark AC, Saad ZH, Singh K, Mandal J, Wemmie JA, Welsh MJ. Author response: Transient acidosis while retrieving a fear-related memory enhances its lability Elife. DOI: 10.7554/Elife.22564.018 |
0.714 |
|
| 2016 |
Reznikov LR, Meyerholz DK, Adam RJ, Abou Alaiwa M, Jaffer O, Michalski AS, Powers LS, Price MP, Stoltz DA, Welsh MJ. Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice. Plos One. 11: e0166089. PMID 27820848 DOI: 10.1371/Journal.Pone.0166089 |
0.69 |
|
| 2016 |
Steines B, Dickey DD, Bergen J, Excoffon KJ, Weinstein JR, Li X, Yan Z, Alaiwa MH, Shah VS, Bouzek DC, Powers LS, Gansemer ND, Ostedgaard LS, Engelhardt JF, Stoltz DA, ... Welsh MJ, et al. CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes. Jci Insight. 1: e88728. PMID 27699238 DOI: 10.1172/Jci.Insight.88728 |
0.362 |
|
| 2016 |
Cooney AL, Abou Alaiwa MH, Shah VS, Bouzek DC, Stroik MR, Powers LS, Gansemer ND, Meyerholz DK, Welsh MJ, Stoltz DA, Sinn PL, McCray PB. Lentiviral-mediated phenotypic correction of cystic fibrosis pigs. Jci Insight. 1. PMID 27656681 DOI: 10.1172/Jci.Insight.88730 |
0.406 |
|
| 2016 |
Alaiwa MH, Launspach JL, Sheets KA, Rivera JA, Gansemer ND, Taft PJ, Thorne PS, Welsh MJ, Stoltz DA, Zabner J. Repurposing tromethamine as inhaled therapy to treat CF airway disease. Jci Insight. 1. PMID 27390778 DOI: 10.1172/Jci.Insight.87535 |
0.332 |
|
| 2016 |
Adam RJ, Hisert KB, Dodd JD, Grogan B, Launspach JL, Barnes JK, Gallagher CG, Sieren JP, Gross TJ, Fischer AJ, Cavanaugh JE, Hoffman EA, Singh PK, Welsh MJ, McKone EF, et al. Acute administration of ivacaftor to people with cystic fibrosis and a G551D-CFTR mutation reveals smooth muscle abnormalities. Jci Insight. 1: e86183. PMID 27158673 DOI: 10.1172/Jci.Insight.86183 |
0.314 |
|
| 2016 |
Shah VS, Ernst S, Tang XX, Karp PH, Parker CP, Ostedgaard LS, Welsh MJ. Relationships among CFTR expression, HCO3- secretion, and host defense may inform gene- and cell-based cystic fibrosis therapies. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114540 DOI: 10.1073/Pnas.1604905113 |
0.385 |
|
| 2016 |
Bartlett JA, Ramachandran S, Wohlford-Lenane CL, Barker CK, Pezzulo AA, Zabner J, Welsh MJ, Meyerholz DK, Stoltz DA, McCray PB. Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus. American Journal of Respiratory and Critical Care Medicine. PMID 27027566 DOI: 10.1164/Rccm.201510-2112Oc |
0.302 |
|
| 2016 |
Shah VS, Meyerholz DK, Tang XX, Reznikov L, Abou Alaiwa M, Ernst SE, Karp PH, Wohlford-Lenane CL, Heilmann KP, Leidinger MR, Allen PD, Zabner J, McCray PB, Ostedgaard LS, Stoltz DA, ... ... Welsh MJ, et al. Airway acidification initiates host defense abnormalities in cystic fibrosis mice. Science (New York, N.Y.). 351: 503-7. PMID 26823428 DOI: 10.1126/Science.Aad5589 |
0.683 |
|
| 2016 |
Tang XX, Ostedgaard LS, Hoegger MJ, Moninger TO, Karp PH, McMenimen JD, Choudhury B, Varki A, Stoltz DA, Welsh MJ. Acidic pH increases airway surface liquid viscosity in cystic fibrosis. The Journal of Clinical Investigation. PMID 26808501 DOI: 10.1172/Jci83922 |
0.347 |
|
| 2016 |
Li X, Tang XX, Vargas Buonfiglio LG, Comellas AP, Thornell IM, Ramachandran S, Karp PH, Taft PJ, Sheets K, Abou Alaiwa MH, Welsh MJ, Meyerholz DK, Stoltz DA, Zabner J. Electrolyte transport properties in distal small airways from cystic fibrosis pigs with implications for host defense. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00422.2015. PMID 26801568 DOI: 10.1152/Ajplung.00422.2015 |
0.355 |
|
| 2015 |
Meyerholz DK, Lambertz AM, Reznikov LR, Ofori-Amanfo GK, Karp PH, McCray PB, Welsh MJ, Stoltz DA. Immunohistochemical Detection of Markers for Translational Studies of Lung Disease in Pigs and Humans. Toxicologic Pathology. PMID 26511846 DOI: 10.1177/0192623315609691 |
0.633 |
|
| 2015 |
Dlouhy BJ, Gehlbach BK, Kreple CJ, Kawasaki H, Oya H, Buzza C, Granner MA, Welsh MJ, Howard MA, Wemmie JA, Richerson GB. Breathing Inhibited When Seizures Spread to the Amygdala and upon Amygdala Stimulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10281-9. PMID 26180203 DOI: 10.1523/Jneurosci.0888-15.2015 |
0.573 |
|
| 2015 |
Dong Q, Ernst SE, Ostedgaard LS, Shah VS, Ver Heul AR, Welsh MJ, Randak CO. Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in Primary Human Airway Epithelia. The Journal of Biological Chemistry. 290: 14140-53. PMID 25887396 DOI: 10.1074/Jbc.M114.611616 |
0.397 |
|
| 2015 |
Stoltz DA, Meyerholz DK, Welsh MJ. Origins of cystic fibrosis lung disease. The New England Journal of Medicine. 372: 351-62. PMID 25607428 DOI: 10.1056/Nejmra1300109 |
0.317 |
|
| 2015 |
Chang EH, Tang XX, Shah VS, Launspach JL, Ernst SE, Hilkin B, Karp PH, Abou Alaiwa MH, Graham SM, Hornick DB, Welsh MJ, Stoltz DA, Zabner J. Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor. International Forum of Allergy & Rhinology. 5: 178-81. PMID 25363320 DOI: 10.1002/Alr.21440 |
0.303 |
|
| 2015 |
Uc A, Olivier AK, Griffin MA, Meyerholz DK, Yao J, Abu-El-Haija M, Buchanan KM, Vanegas Calderón OG, Abu-El-Haija M, Pezzulo AA, Reznikov LR, Hoegger MJ, Rector MV, Ostedgaard LS, Taft PJ, ... ... Welsh MJ, et al. Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass. Clinical Science (London, England : 1979). 128: 131-42. PMID 25142104 DOI: 10.1042/Cs20140059 |
0.641 |
|
| 2015 |
Dlouhy BJ, Gehlbach BK, Kreple CJ, Kawasaki H, Oya H, Buzza C, Granner MA, Welsh MJ, Howard MA, Wemmie JA, Richerson GB. Breathing inhibited when seizures spread to the amygdala and upon amygdala stimulation Journal of Neuroscience. 35: 10281-10289. DOI: 10.1523/JNEUROSCI.0888-15.2015 |
0.515 |
|
| 2015 |
Cooney AL, Abou Alaiwa MH, Stoltz DA, Welsh MJ, Sinn PL, McCray PB. 7. Lentiviral Vector-Mediated CFTR Gene Transfer to CF Pig Airways Corrects the Anion Transport Defect In Vivo Molecular Therapy. 23: S3. DOI: 10.1016/S1525-0016(16)33611-5 |
0.366 |
|
| 2014 |
Abou Alaiwa MH, Reznikov LR, Gansemer ND, Sheets KA, Horswill AR, Stoltz DA, Zabner J, Welsh MJ. pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37. Proceedings of the National Academy of Sciences of the United States of America. 111: 18703-8. PMID 25512526 DOI: 10.1073/Pnas.1422091112 |
0.646 |
|
| 2014 |
Du J, Reznikov LR, Welsh MJ. Expression and activity of acid-sensing ion channels in the mouse anterior pituitary. Plos One. 9: e115310. PMID 25506946 DOI: 10.1371/Journal.Pone.0115310 |
0.805 |
|
| 2014 |
Hoegger MJ, Fischer AJ, McMenimen JD, Ostedgaard LS, Tucker AJ, Awadalla MA, Moninger TO, Michalski AS, Hoffman EA, Zabner J, Stoltz DA, Welsh MJ. Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis. Science (New York, N.Y.). 345: 818-22. PMID 25124441 DOI: 10.1126/Science.1255825 |
0.325 |
|
| 2014 |
Kreple CJ, Lu Y, Taugher RJ, Schwager-Gutman AL, Du J, Stump M, Wang Y, Ghobbeh A, Fan R, Cosme CV, Sowers LP, Welsh MJ, Radley JJ, LaLumiere RT, Wemmie JA. Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity. Nature Neuroscience. 17: 1083-91. PMID 24952644 DOI: 10.1038/Nn.3750 |
0.742 |
|
| 2014 |
Du J, Reznikov LR, Price MP, Zha XM, Lu Y, Moninger TO, Wemmie JA, Welsh MJ. Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala. Proceedings of the National Academy of Sciences of the United States of America. 111: 8961-6. PMID 24889629 DOI: 10.1073/Pnas.1407018111 |
0.793 |
|
| 2014 |
Ramachandran S, Osterhaus SR, Karp PH, Welsh MJ, McCray PB. A genomic signature approach to rescue ΔF508-cystic fibrosis transmembrane conductance regulator biosynthesis and function. American Journal of Respiratory Cell and Molecular Biology. 51: 354-62. PMID 24669817 DOI: 10.1165/Rcmb.2014-0007Oc |
0.3 |
|
| 2014 |
Reznikov LR, Abou Alaiwa MH, Dohrn CL, Gansemer ND, Diekema DJ, Stoltz DA, Welsh MJ. Antibacterial properties of the CFTR potentiator ivacaftor. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 13: 515-9. PMID 24618508 DOI: 10.1016/J.Jcf.2014.02.004 |
0.672 |
|
| 2014 |
Abou Alaiwa MH, Beer AM, Pezzulo AA, Launspach JL, Horan RA, Stoltz DA, Starner TD, Welsh MJ, Zabner J. Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 13: 373-7. PMID 24418186 DOI: 10.1016/J.Jcf.2013.12.006 |
0.311 |
|
| 2014 |
Price MP, Gong H, Parsons MG, Kundert JR, Reznikov LR, Bernardinelli L, Chaloner K, Buchanan GF, Wemmie JA, Richerson GB, Cassell MD, Welsh MJ. Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli. Genes, Brain, and Behavior. 13: 179-94. PMID 24256442 DOI: 10.1111/Gbb.12108 |
0.77 |
|
| 2014 |
Gu X, Karp PH, Brody SL, Pierce RA, Welsh MJ, Holtzman MJ, Ben-Shahar Y. Chemosensory functions for pulmonary neuroendocrine cells. American Journal of Respiratory Cell and Molecular Biology. 50: 637-46. PMID 24134460 DOI: 10.1165/Rcmb.2013-0199Oc |
0.322 |
|
| 2014 |
Dlouhy BJ, Gehlbach BK, Kreple CJ, Kawasaki H, Oya H, Buzza C, Granner MA, Welsh MJ, Howard MA, Wemmie JA, Richerson GB. 190 Mechanism for Sudden Unexpected Death in Epilepsy Neurosurgery. 61: 223. DOI: 10.1227/01.Neu.0000452464.34409.03 |
0.542 |
|
| 2013 |
Yin T, Lindley TE, Albert GW, Ahmed R, Schmeiser PB, Grady MS, Howard MA, Welsh MJ. Loss of Acid sensing ion channel-1a and bicarbonate administration attenuate the severity of traumatic brain injury. Plos One. 8: e72379. PMID 23991103 DOI: 10.1371/Journal.Pone.0072379 |
0.306 |
|
| 2013 |
Stoltz DA, Rokhlina T, Ernst SE, Pezzulo AA, Ostedgaard LS, Karp PH, Samuel MS, Reznikov LR, Rector MV, Gansemer ND, Bouzek DC, Alaiwa MH, Hoegger MJ, Ludwig PS, Taft PJ, ... ... Welsh MJ, et al. Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. The Journal of Clinical Investigation. 123: 2685-93. PMID 23676501 DOI: 10.1172/Jci68867 |
0.671 |
|
| 2013 |
Reznikov LR, Dong Q, Chen JH, Moninger TO, Park JM, Zhang Y, Du J, Hildebrand MS, Smith RJ, Randak CO, Stoltz DA, Welsh MJ. CFTR-deficient pigs display peripheral nervous system defects at birth. Proceedings of the National Academy of Sciences of the United States of America. 110: 3083-8. PMID 23382208 DOI: 10.1073/Pnas.1222729110 |
0.764 |
|
| 2013 |
Feinstein JS, Buzza C, Hurlemann R, Follmer RL, Dahdaleh NS, Coryell WH, Welsh MJ, Tranel D, Wemmie JA. Fear and panic in humans with bilateral amygdala damage. Nature Neuroscience. 16: 270-2. PMID 23377128 DOI: 10.1038/Nn.3323 |
0.575 |
|
| 2012 |
Randak CO, Ver Heul AR, Welsh MJ. Demonstration of phosphoryl group transfer indicates that the ATP-binding cassette (ABC) transporter cystic fibrosis transmembrane conductance regulator (CFTR) exhibits adenylate kinase activity. The Journal of Biological Chemistry. 287: 36105-10. PMID 22948143 DOI: 10.1074/Jbc.M112.408450 |
0.328 |
|
| 2012 |
Ramachandran S, Karp PH, Jiang P, Ostedgaard LS, Walz AE, Fisher JT, Keshavjee S, Lennox KA, Jacobi AM, Rose SD, Behlke MA, Welsh MJ, Xing Y, McCray PB. A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator. Proceedings of the National Academy of Sciences of the United States of America. 109: 13362-7. PMID 22853952 DOI: 10.1073/Pnas.1210906109 |
0.315 |
|
| 2012 |
Pezzulo AA, Tang XX, Hoegger MJ, Alaiwa MH, Ramachandran S, Moninger TO, Karp PH, Wohlford-Lenane CL, Haagsman HP, van Eijk M, Bánfi B, Horswill AR, Stoltz DA, McCray PB, Welsh MJ, et al. Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature. 487: 109-13. PMID 22763554 DOI: 10.1038/Nature11130 |
0.352 |
|
| 2012 |
Chang EH, Pezzulo AA, Meyerholz DK, Potash AE, Wallen TJ, Reznikov LR, Sieren JC, Karp PH, Ernst S, Moninger TO, Gansemer ND, McCray PB, Stoltz DA, Welsh MJ, Zabner J. Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis. The Laryngoscope. 122: 1898-905. PMID 22711071 DOI: 10.1002/Lary.23392 |
0.662 |
|
| 2012 |
Abu-El-Haija M, Ramachandran S, Meyerholz DK, Abu-El-Haija M, Griffin M, Giriyappa RL, Stoltz DA, Welsh MJ, McCray PB, Uc A. Pancreatic damage in fetal and newborn cystic fibrosis pigs involves the activation of inflammatory and remodeling pathways. The American Journal of Pathology. 181: 499-507. PMID 22683312 DOI: 10.1016/J.Ajpath.2012.04.024 |
0.316 |
|
| 2012 |
Li X, Comellas AP, Karp PH, Ernst SE, Moninger TO, Gansemer ND, Taft PJ, Pezzulo AA, Rector MV, Rossen N, Stoltz DA, McCray PB, Welsh MJ, Zabner J. CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia. American Journal of Physiology. Lung Cellular and Molecular Physiology. 303: L152-60. PMID 22637155 DOI: 10.1152/Ajplung.00116.2012 |
0.308 |
|
| 2012 |
Magnotta VA, Heo HY, Dlouhy BJ, Dahdaleh NS, Follmer RL, Thedens DR, Welsh MJ, Wemmie JA. Detecting activity-evoked pH changes in human brain. Proceedings of the National Academy of Sciences of the United States of America. 109: 8270-3. PMID 22566645 DOI: 10.1073/Pnas.1205902109 |
0.578 |
|
| 2012 |
Kang S, Jang JH, Price MP, Gautam M, Benson CJ, Gong H, Welsh MJ, Brennan TJ. Simultaneous disruption of mouse ASIC1a, ASIC2 and ASIC3 genes enhances cutaneous mechanosensitivity. Plos One. 7: e35225. PMID 22506072 DOI: 10.1371/Journal.Pone.0035225 |
0.362 |
|
| 2012 |
Lu B, LaMora A, Sun Y, Welsh MJ, Ben-Shahar Y. ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster. Plos Genetics. 8: e1002587. PMID 22438833 DOI: 10.1371/Journal.Pgen.1002587 |
0.763 |
|
| 2012 |
Ramsey BW, Banks-Schlegel S, Accurso FJ, Boucher RC, Cutting GR, Engelhardt JF, Guggino WB, Karp CL, Knowles MR, Kolls JK, LiPuma JJ, Lynch S, McCray PB, Rubenstein RC, Singh PK, ... ... Welsh M, et al. Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report. American Journal of Respiratory and Critical Care Medicine. 185: 887-92. PMID 22312017 DOI: 10.1164/Rccm.201111-2068Ws |
0.306 |
|
| 2012 |
Dong Q, Ostedgaard LS, Rogers C, Vermeer DW, Zhang Y, Welsh MJ. Human-mouse cystic fibrosis transmembrane conductance regulator (CFTR) chimeras identify regions that partially rescue CFTR-ΔF508 processing and alter its gating defect. Proceedings of the National Academy of Sciences of the United States of America. 109: 917-22. PMID 22210114 DOI: 10.1073/Pnas.1120065109 |
0.327 |
|
| 2012 |
Lacruz RS, Smith CE, Moffatt P, Chang EH, Bromage TG, Bringas P, Nanci A, Baniwal SK, Zabner J, Welsh MJ, Kurtz I, Paine ML. Requirements for ion and solute transport, and pH regulation during enamel maturation. Journal of Cellular Physiology. 227: 1776-85. PMID 21732355 DOI: 10.1002/Jcp.22911 |
0.348 |
|
| 2011 |
Itani OA, Chen JH, Karp PH, Ernst S, Keshavjee S, Parekh K, Klesney-Tait J, Zabner J, Welsh MJ. Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance. Proceedings of the National Academy of Sciences of the United States of America. 108: 10260-5. PMID 21646513 DOI: 10.1073/Pnas.1106695108 |
0.386 |
|
| 2011 |
Chang EH, Lacruz RS, Bromage TG, Bringas P, Welsh MJ, Zabner J, Paine ML. Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model. Cells, Tissues, Organs. 194: 249-54. PMID 21525720 DOI: 10.1159/000324248 |
0.393 |
|
| 2011 |
Ostedgaard LS, Meyerholz DK, Chen JH, Pezzulo AA, Karp PH, Rokhlina T, Ernst SE, Hanfland RA, Reznikov LR, Ludwig PS, Rogan MP, Davis GJ, Dohrn CL, Wohlford-Lenane C, Taft PJ, ... ... Welsh MJ, et al. The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. Science Translational Medicine. 3: 74ra24. PMID 21411740 DOI: 10.1126/Scitranslmed.3001868 |
0.657 |
|
| 2011 |
Lorentzen D, Durairaj L, Pezzulo AA, Nakano Y, Launspach J, Stoltz DA, Zamba G, McCray PB, Zabner J, Welsh MJ, Nauseef WM, Bánfi B. Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions. Free Radical Biology & Medicine. 50: 1144-50. PMID 21334431 DOI: 10.1016/J.Freeradbiomed.2011.02.013 |
0.335 |
|
| 2011 |
Vralsted VC, Price MP, Du J, Schnizler M, Wunsch AM, Ziemann AE, Welsh MJ, Wemmie JA. Expressing acid-sensing ion channel 3 in the brain alters acid-evoked currents and impairs fear conditioning. Genes, Brain, and Behavior. 10: 444-50. PMID 21324060 DOI: 10.1111/J.1601-183X.2011.00683.X |
0.802 |
|
| 2011 |
Ostedgaard LS, Meyerholz DK, Vermeer DW, Karp PH, Schneider L, Sigmund CD, Welsh MJ. Cystic fibrosis transmembrane conductance regulator with a shortened R domain rescues the intestinal phenotype of CFTR-/- mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 2921-6. PMID 21285372 DOI: 10.1073/Pnas.1019752108 |
0.327 |
|
| 2010 |
Chen JH, Stoltz DA, Karp PH, Ernst SE, Pezzulo AA, Moninger TO, Rector MV, Reznikov LR, Launspach JL, Chaloner K, Zabner J, Welsh MJ. Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia. Cell. 143: 911-23. PMID 21145458 DOI: 10.1016/J.Cell.2010.11.029 |
0.677 |
|
| 2010 |
Rogan MP, Reznikov LR, Pezzulo AA, Gansemer ND, Samuel M, Prather RS, Zabner J, Fredericks DC, McCray PB, Welsh MJ, Stoltz DA. Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth. Proceedings of the National Academy of Sciences of the United States of America. 107: 20571-5. PMID 21059918 DOI: 10.1073/Pnas.1015281107 |
0.643 |
|
| 2010 |
Meyerholz DK, Stoltz DA, Namati E, Ramachandran S, Pezzulo AA, Smith AR, Rector MV, Suter MJ, Kao S, McLennan G, Tearney GJ, Zabner J, McCray PB, Welsh MJ. Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children. American Journal of Respiratory and Critical Care Medicine. 182: 1251-61. PMID 20622026 DOI: 10.1164/Rccm.201004-0643Oc |
0.312 |
|
| 2010 |
Stoltz DA, Meyerholz DK, Pezzulo AA, Ramachandran S, Rogan MP, Davis GJ, Hanfland RA, Wohlford-Lenane C, Dohrn CL, Bartlett JA, Nelson GA, Chang EH, Taft PJ, Ludwig PS, Estin M, ... ... Welsh MJ, et al. Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Science Translational Medicine. 2: 29ra31. PMID 20427821 DOI: 10.1126/Scitranslmed.3000928 |
0.306 |
|
| 2010 |
Ben-Shahar Y, Lu B, Collier DM, Snyder PM, Schnizler M, Welsh MJ. The Drosophila gene CheB42a is a novel modifier of Deg/ENaC channel function. Plos One. 5: e9395. PMID 20195381 DOI: 10.1371/Journal.Pone.0009395 |
0.423 |
|
| 2010 |
Meyerholz DK, Stoltz DA, Pezzulo AA, Welsh MJ. Pathology of gastrointestinal organs in a porcine model of cystic fibrosis. The American Journal of Pathology. 176: 1377-89. PMID 20110417 DOI: 10.2353/Ajpath.2010.090849 |
0.324 |
|
| 2009 |
Lu Y, Ma X, Sabharwal R, Snitsarev V, Morgan D, Rahmouni K, Drummond HA, Whiteis CA, Costa V, Price M, Benson C, Welsh MJ, Chapleau MW, Abboud FM. The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation. Neuron. 64: 885-97. PMID 20064394 DOI: 10.1016/J.Neuron.2009.11.007 |
0.58 |
|
| 2009 |
Ziemann AE, Allen JE, Dahdaleh NS, Drebot II, Coryell MW, Wunsch AM, Lynch CM, Faraci FM, Howard MA, Welsh MJ, Wemmie JA. The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior. Cell. 139: 1012-21. PMID 19945383 DOI: 10.1016/J.Cell.2009.10.029 |
0.768 |
|
| 2009 |
Sun Y, Liu L, Ben-Shahar Y, Jacobs JS, Eberl DF, Welsh MJ. TRPA channels distinguish gravity sensing from hearing in Johnston's organ. Proceedings of the National Academy of Sciences of the United States of America. 106: 13606-11. PMID 19666538 DOI: 10.1073/Pnas.0906377106 |
0.749 |
|
| 2009 |
Shah AS, Ben-Shahar Y, Moninger TO, Kline JN, Welsh MJ. Motile cilia of human airway epithelia are chemosensory. Science (New York, N.Y.). 325: 1131-4. PMID 19628819 DOI: 10.1126/Science.1173869 |
0.585 |
|
| 2009 |
Zha XM, Costa V, Harding AM, Reznikov L, Benson CJ, Welsh MJ. ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 8438-46. PMID 19571134 DOI: 10.1523/Jneurosci.1284-09.2009 |
0.752 |
|
| 2009 |
Zha XM, Wang R, Collier DM, Snyder PM, Wemmie JA, Welsh MJ. Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits. Proceedings of the National Academy of Sciences of the United States of America. 106: 3573-8. PMID 19218436 DOI: 10.1073/Pnas.0813402106 |
0.629 |
|
| 2009 |
Flynn AN, Itani OA, Moninger TO, Welsh MJ. Acute regulation of tight junction ion selectivity in human airway epithelia. Proceedings of the National Academy of Sciences of the United States of America. 106: 3591-6. PMID 19208806 DOI: 10.1073/Pnas.0813393106 |
0.711 |
|
| 2009 |
Schnizler MK, Schnizler K, Zha XM, Hall DD, Wemmie JA, Hell JW, Welsh MJ. The cytoskeletal protein alpha-actinin regulates acid-sensing ion channel 1a through a C-terminal interaction. The Journal of Biological Chemistry. 284: 2697-705. PMID 19028690 DOI: 10.1074/Jbc.M805110200 |
0.625 |
|
| 2008 |
Rogers CS, Stoltz DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Hanfland RA, Smith TL, ... ... Welsh MJ, et al. Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science (New York, N.Y.). 321: 1837-41. PMID 18818360 DOI: 10.1126/Science.1163600 |
0.352 |
|
| 2008 |
Dong Q, Randak CO, Welsh MJ. A mutation in CFTR modifies the effects of the adenylate kinase inhibitor Ap5A on channel gating. Biophysical Journal. 95: 5178-85. PMID 18805924 DOI: 10.1529/Biophysj.108.140897 |
0.395 |
|
| 2008 |
Eshcol JO, Harding AM, Hattori T, Costa V, Welsh MJ, Benson CJ. Acid-sensing ion channel 3 (ASIC3) cell surface expression is modulated by PSD-95 within lipid rafts. American Journal of Physiology. Cell Physiology. 295: C732-9. PMID 18579798 DOI: 10.1152/Ajpcell.00514.2007 |
0.573 |
|
| 2008 |
Ziemann AE, Schnizler MK, Albert GW, Severson MA, Howard MA, Welsh MJ, Wemmie JA. Seizure termination by acidosis depends on ASIC1a. Nature Neuroscience. 11: 816-22. PMID 18536711 DOI: 10.1038/Nn.2132 |
0.76 |
|
| 2008 |
Rogers CS, Abraham WM, Brogden KA, Engelhardt JF, Fisher JT, McCray PB, McLennan G, Meyerholz DK, Namati E, Ostedgaard LS, Prather RS, Sabater JR, Stoltz DA, Zabner J, Welsh MJ. The porcine lung as a potential model for cystic fibrosis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 295: L240-63. PMID 18487356 DOI: 10.1152/Ajplung.90203.2008 |
0.328 |
|
| 2008 |
Sun X, Yan Z, Yi Y, Li Z, Lei D, Rogers CS, Chen J, Zhang Y, Welsh MJ, Leno GH, Engelhardt JF. Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets. The Journal of Clinical Investigation. 118: 1578-83. PMID 18324338 DOI: 10.1172/Jci34599 |
0.311 |
|
| 2008 |
Rogers CS, Hao Y, Rokhlina T, Samuel M, Stoltz DA, Li Y, Petroff E, Vermeer DW, Kabel AC, Yan Z, Spate L, Wax D, Murphy CN, Rieke A, Whitworth K, ... ... Welsh MJ, et al. Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer. The Journal of Clinical Investigation. 118: 1571-7. PMID 18324337 DOI: 10.1172/Jci34773 |
0.329 |
|
| 2008 |
Shah AS, Farmen SL, Moninger TO, Businga TR, Andrews MP, Bugge K, Searby CC, Nishimura D, Brogden KA, Kline JN, Sheffield VC, Welsh MJ. Loss of Bardet-Biedl syndrome proteins alters the morphology and function of motile cilia in airway epithelia. Proceedings of the National Academy of Sciences of the United States of America. 105: 3380-5. PMID 18299575 DOI: 10.1073/Pnas.0712327105 |
0.78 |
|
| 2008 |
Petroff EY, Price MP, Snitsarev V, Gong H, Korovkina V, Abboud FM, Welsh MJ. Acid-sensing ion channels interact with and inhibit BK K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 105: 3140-4. PMID 18287010 DOI: 10.1073/Pnas.0712280105 |
0.417 |
|
| 2008 |
Flynn A, Itani O, Welsh M. Elevated Intracellular Calcium Transiently Increases Tight Junction Na+ Conductance in Human Airway Epithelia The Faseb Journal. 22: 132-132. DOI: 10.1096/Fasebj.22.2_Supplement.132 |
0.69 |
|
| 2008 |
Wemmie JA, Zha XM, Welsh MJ. Acid-sensing ion channels (ASICs) and ph in synapse physiology Structural and Functional Organization of the Synapse. 661-681. DOI: 10.1007/978-0-387-77232-5_22 |
0.591 |
|
| 2007 |
Friese MA, Craner MJ, Etzensperger R, Vergo S, Wemmie JA, Welsh MJ, Vincent A, Fugger L. Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. Nature Medicine. 13: 1483-9. PMID 17994101 DOI: 10.1038/Nm1668 |
0.62 |
|
| 2007 |
Liu L, Li Y, Wang R, Yin C, Dong Q, Hing H, Kim C, Welsh MJ. Drosophila hygrosensation requires the TRP channels water witch and nanchung. Nature. 450: 294-8. PMID 17994098 DOI: 10.1038/Nature06223 |
0.358 |
|
| 2007 |
Randak CO, Welsh MJ. Role of CFTR's intrinsic adenylate kinase activity in gating of the Cl(-) channel. Journal of Bioenergetics and Biomembranes. 39: 473-9. PMID 17965924 DOI: 10.1007/S10863-007-9119-5 |
0.397 |
|
| 2007 |
Ostedgaard LS, Rogers CS, Dong Q, Randak CO, Vermeer DW, Rokhlina T, Karp PH, Welsh MJ. Processing and function of CFTR-DeltaF508 are species-dependent. Proceedings of the National Academy of Sciences of the United States of America. 104: 15370-5. PMID 17873061 DOI: 10.1073/Pnas.0706974104 |
0.396 |
|
| 2007 |
Itani OA, Lamb FS, Melvin JE, Welsh MJ. Basolateral chloride current in human airway epithelia. American Journal of Physiology. Lung Cellular and Molecular Physiology. 293: L991-9. PMID 17660331 DOI: 10.1152/Ajplung.00077.2007 |
0.385 |
|
| 2006 |
Zha XM, Wemmie JA, Green SH, Welsh MJ. Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines. Proceedings of the National Academy of Sciences of the United States of America. 103: 16556-61. PMID 17060608 DOI: 10.1073/Pnas.0608018103 |
0.628 |
|
| 2006 |
Wemmie JA, Price MP, Welsh MJ. Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends in Neurosciences. 29: 578-86. PMID 16891000 DOI: 10.1016/J.Tins.2006.06.014 |
0.637 |
|
| 2005 |
Farmen SL, Karp PH, Ng P, Palmer DJ, Koehler DR, Hu J, Beaudet AL, Zabner J, Welsh MJ. Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl- transport and overexpression can generate basolateral CFTR. American Journal of Physiology. Lung Cellular and Molecular Physiology. 289: L1123-30. PMID 16085675 DOI: 10.1152/Ajplung.00049.2005 |
0.798 |
|
| 2005 |
Ostedgaard LS, Rokhlina T, Karp PH, Lashmit P, Afione S, Schmidt M, Zabner J, Stinski MF, Chiorini JA, Welsh MJ. A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia. Proceedings of the National Academy of Sciences of the United States of America. 102: 2952-7. PMID 15703296 DOI: 10.1073/Pnas.0409845102 |
0.347 |
|
| 2005 |
Randak CO, Welsh MJ. ADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 102: 2216-20. PMID 15684079 DOI: 10.1073/Pnas.0409787102 |
0.335 |
|
| 2005 |
Berger AL, Ikuma M, Welsh MJ. Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain. Proceedings of the National Academy of Sciences of the United States of America. 102: 455-60. PMID 15623556 DOI: 10.1073/Pnas.0408575102 |
0.315 |
|
| 2005 |
Berger AL, Randak CO, Ostedgaard LS, Karp PH, Vermeer DW, Welsh MJ. Curcumin stimulates cystic fibrosis transmembrane conductance regulator Cl- channel activity. The Journal of Biological Chemistry. 280: 5221-6. PMID 15582996 DOI: 10.1074/Jbc.M412972200 |
0.418 |
|
| 2004 |
Page AJ, Brierley SM, Martin CM, Martinez-Salgado C, Wemmie JA, Brennan TJ, Symonds E, Omari T, Lewin GR, Welsh MJ, Blackshaw LA. The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function. Gastroenterology. 127: 1739-47. PMID 15578512 DOI: 10.1053/J.Gastro.2004.08.061 |
0.638 |
|
| 2004 |
Xiong ZG, Zhu XM, Chu XP, Minami M, Hey J, Wei WL, MacDonald JF, Wemmie JA, Price MP, Welsh MJ, Simon RP. Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell. 118: 687-98. PMID 15369669 DOI: 10.1016/J.Cell.2004.08.026 |
0.607 |
|
| 2004 |
Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. The Journal of Biological Chemistry. 279: 46962-8. PMID 15317815 DOI: 10.1074/Jbc.M405874200 |
0.379 |
|
| 2004 |
Yermolaieva O, Leonard AS, Schnizler MK, Abboud FM, Welsh MJ. Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a. Proceedings of the National Academy of Sciences of the United States of America. 101: 6752-7. PMID 15082829 DOI: 10.1073/Pnas.0308636100 |
0.353 |
|
| 2004 |
Wemmie JA, Coryell MW, Askwith CC, Lamani E, Leonard AS, Sigmund CD, Welsh MJ. Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proceedings of the National Academy of Sciences of the United States of America. 101: 3621-6. PMID 14988500 DOI: 10.1073/Pnas.0308753101 |
0.788 |
|
| 2004 |
Askwith CC, Wemmie JA, Price MP, Rokhlina T, Welsh MJ. Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons. The Journal of Biological Chemistry. 279: 18296-305. PMID 14960591 DOI: 10.1074/Jbc.M312145200 |
0.774 |
|
| 2004 |
Scheetz TE, Zabner J, Welsh MJ, Coco J, Eyestone Mde F, Bonaldo M, Kucaba T, Casavant TL, Soares MB, McCray PB. Large-scale gene discovery in human airway epithelia reveals novel transcripts. Physiological Genomics. 17: 69-77. PMID 14701920 DOI: 10.1152/Physiolgenomics.00188.2003 |
0.305 |
|
| 2004 |
Farmen SL, Karp PH, Ng P, Koehler DR, Hu J, Zabner J, Welsh MJ. 110. Helper-Dependent Adenovirus with the Cytokeratin-18 Promoter Produces Greater Transepithelial Chloride Current and More Persistent Transgene Expression Than the CMV Promoter in Differentiated Human Airway Epithelia Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.047 |
0.783 |
|
| 2003 |
Randak C, Welsh MJ. An intrinsic adenylate kinase activity regulates gating of the ABC transporter CFTR. Cell. 115: 837-50. PMID 14697202 DOI: 10.1016/S0092-8674(03)00983-8 |
0.373 |
|
| 2003 |
Sluka KA, Price MP, Breese NM, Stucky CL, Wemmie JA, Welsh MJ. Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Pain. 106: 229-39. PMID 14659506 DOI: 10.1016/S0304-3959(03)00269-0 |
0.6 |
|
| 2003 |
Ainsley JA, Pettus JM, Bosenko D, Gerstein CE, Zinkevich N, Anderson MG, Adams CM, Welsh MJ, Johnson WA. Enhanced locomotion caused by loss of the Drosophila DEG/ENaC protein Pickpocket1. Current Biology : Cb. 13: 1557-63. PMID 12956960 DOI: 10.1016/S0960-9822(03)00596-7 |
0.368 |
|
| 2003 |
Liu L, Leonard AS, Motto DG, Feller MA, Price MP, Johnson WA, Welsh MJ. Contribution of Drosophila DEG/ENaC genes to salt taste. Neuron. 39: 133-46. PMID 12848938 DOI: 10.1016/S0896-6273(03)00394-5 |
0.35 |
|
| 2003 |
Wemmie JA, Askwith CC, Lamani E, Cassell MD, Freeman JH, Welsh MJ. Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5496-502. PMID 12843249 DOI: 10.1523/Jneurosci.23-13-05496.2003 |
0.759 |
|
| 2003 |
Zabner J, Karp P, Seiler M, Phillips SL, Mitchell CJ, Saavedra M, Welsh M, Klingelhutz AJ. Development of cystic fibrosis and noncystic fibrosis airway cell lines. American Journal of Physiology. Lung Cellular and Molecular Physiology. 284: L844-54. PMID 12676769 DOI: 10.1152/Ajplung.00355.2002 |
0.327 |
|
| 2003 |
Xie J, Price MP, Wemmie JA, Askwith CC, Welsh MJ. ASIC3 and ASIC1 mediate FMRFamide-related peptide enhancement of H+-gated currents in cultured dorsal root ganglion neurons. Journal of Neurophysiology. 89: 2459-65. PMID 12612000 DOI: 10.1152/Jn.00707.2002 |
0.781 |
|
| 2003 |
Ostedgaard LS, Randak C, Rokhlina T, Karp P, Vermeer D, Ashbourne Excoffon KJ, Welsh MJ. Effects of C-terminal deletions on cystic fibrosis transmembrane conductance regulator function in cystic fibrosis airway epithelia. Proceedings of the National Academy of Sciences of the United States of America. 100: 1937-42. PMID 12578973 DOI: 10.1073/Pnas.2627982100 |
0.379 |
|
| 2003 |
Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ. cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. Proceedings of the National Academy of Sciences of the United States of America. 100: 2029-34. PMID 12578970 DOI: 10.1073/Pnas.252782799 |
0.748 |
|
| 2003 |
Liu L, Johnson WA, Welsh MJ. Drosophila DEG/ENaC pickpocket genes are expressed in the tracheal system, where they may be involved in liquid clearance. Proceedings of the National Academy of Sciences of the United States of America. 100: 2128-33. PMID 12571352 DOI: 10.1073/Pnas.252785099 |
0.357 |
|
| 2003 |
Martin CM, Page AJ, Wemmie JA, Welsh MJ, Blackshaw L. Altered esophageal mechanosensory function and pharmacology in mice lacking the ASIC ion channel Gastroenterology. 124: A344-A345. DOI: 10.1016/S0016-5085(03)81738-9 |
0.633 |
|
| 2003 |
Brierley SM, Wemmie JA, Welsh MJ, Blackshaw L. ASIC ion channels contribute to colonic mechanosensory function in mice Gastroenterology. 124: A39. DOI: 10.1016/S0016-5085(03)80193-2 |
0.631 |
|
| 2002 |
Walters RW, Freimuth P, Moninger TO, Ganske I, Zabner J, Welsh MJ. Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape. Cell. 110: 789-99. PMID 12297051 DOI: 10.1016/S0092-8674(02)00912-1 |
0.573 |
|
| 2002 |
Xie J, Price MP, Berger AL, Welsh MJ. DRASIC contributes to pH-gated currents in large dorsal root ganglion sensory neurons by forming heteromultimeric channels. Journal of Neurophysiology. 87: 2835-43. PMID 12037186 DOI: 10.1152/Jn.2002.87.6.2835 |
0.539 |
|
| 2002 |
Wemmie JA, Chen J, Askwith CC, Hruska-Hageman AM, Price MP, Nolan BC, Yoder PG, Lamani E, Hoshi T, Freeman JH, Welsh MJ. The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron. 34: 463-77. PMID 11988176 DOI: 10.1016/S0896-6273(02)00661-X |
0.762 |
|
| 2002 |
Benson CJ, Xie J, Wemmie JA, Price MP, Henss JM, Welsh MJ, Snyder PM. Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proceedings of the National Academy of Sciences of the United States of America. 99: 2338-43. PMID 11854527 DOI: 10.1073/Pnas.032678399 |
0.695 |
|
| 2002 |
Ostedgaard LS, Zabner J, Vermeer DW, Rokhlina T, Karp PH, Stecenko AA, Randak C, Welsh MJ. CFTR with a partially deleted R domain corrects the cystic fibrosis chloride transport defect in human airway epithelia in vitro and in mouse nasal mucosa in vivo. Proceedings of the National Academy of Sciences of the United States of America. 99: 3093-8. PMID 11854474 DOI: 10.1073/Pnas.261714599 |
0.391 |
|
| 2002 |
Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ. Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel). The Biochemical Journal. 361: 443-50. PMID 11802773 DOI: 10.1042/0264-6021:3610443 |
0.66 |
|
| 2002 |
Berger AL, Ikuma M, Hunt JF, Thomas PJ, Welsh MJ. Mutations that change the position of the putative gamma-phosphate linker in the nucleotide binding domains of CFTR alter channel gating. The Journal of Biological Chemistry. 277: 2125-31. PMID 11788611 DOI: 10.1074/Jbc.M109539200 |
0.379 |
|
| 2002 |
Welsh MJ, Price MP, Xie J. Biochemical basis of touch perception: mechanosensory function of degenerin/epithelial Na+ channels. The Journal of Biological Chemistry. 277: 2369-72. PMID 11706013 DOI: 10.1074/Jbc.R100060200 |
0.537 |
|
| 2001 |
Price MP, McIlwrath SL, Xie J, Cheng C, Qiao J, Tarr DE, Sluka KA, Brennan TJ, Lewin GR, Welsh MJ. The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron. 32: 1071-83. PMID 11754838 DOI: 10.1016/S0896-6273(01)00547-5 |
0.585 |
|
| 2001 |
Walters RW, van't Hof W, Yi SM, Schroth MK, Zabner J, Crystal RG, Welsh MJ. Apical localization of the coxsackie-adenovirus receptor by glycosyl-phosphatidylinositol modification is sufficient for adenovirus-mediated gene transfer through the apical surface of human airway epithelia. Journal of Virology. 75: 7703-11. PMID 11462042 DOI: 10.1128/Jvi.75.16.7703-7711.2001 |
0.611 |
|
| 2001 |
Prince LS, Karp PH, Moninger TO, Welsh MJ. KGF alters gene expression in human airway epithelia: potential regulation of the inflammatory response. Physiological Genomics. 6: 81-9. PMID 11459923 DOI: 10.1152/Physiolgenomics.2001.6.2.81 |
0.379 |
|
| 2001 |
Drummond HA, Welsh MJ, Abboud FM. ENaC subunits are molecular components of the arterial baroreceptor complex. Annals of the New York Academy of Sciences. 940: 42-7. PMID 11458698 DOI: 10.1111/J.1749-6632.2001.Tb03665.X |
0.36 |
|
| 2001 |
Askwith CC, Benson CJ, Welsh MJ, Snyder PM. DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature. Proceedings of the National Academy of Sciences of the United States of America. 98: 6459-63. PMID 11353858 DOI: 10.1073/Pnas.111155398 |
0.698 |
|
| 2001 |
Walters RW, Yi SM, Keshavjee S, Brown KE, Welsh MJ, Chiorini JA, Zabner J. Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer. The Journal of Biological Chemistry. 276: 20610-6. PMID 11262413 DOI: 10.1074/Jbc.M101559200 |
0.599 |
|
| 2001 |
Hennager DJ, Ikuma M, Hoshi T, Welsh MJ. A conditional probability analysis of cystic fibrosis transmembrane conductance regulator gating indicates that ATP has multiple effects during the gating cycle. Proceedings of the National Academy of Sciences of the United States of America. 98: 3594-9. PMID 11248123 DOI: 10.1073/Pnas.051633298 |
0.778 |
|
| 2001 |
Ostedgaard LS, Baldursson O, Welsh MJ. Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by its R domain. The Journal of Biological Chemistry. 276: 7689-92. PMID 11244086 DOI: 10.1074/Jbc.R100001200 |
0.357 |
|
| 2000 |
Drummond HA, Abboud FM, Welsh MJ. Localization of beta and gamma subunits of ENaC in sensory nerve endings in the rat foot pad. Brain Research. 884: 1-12. PMID 11082481 DOI: 10.1016/S0006-8993(00)02831-6 |
0.318 |
|
| 2000 |
Price MP, Lewin GR, McIlwrath SL, Cheng C, Xie J, Heppenstall PA, Stucky CL, Mannsfeldt AG, Brennan TJ, Drummond HA, Qiao J, Benson CJ, Tarr DE, Hrstka RF, Yang B, ... ... Welsh MJ, et al. The mammalian sodium channel BNC1 is required for normal touch sensation. Nature. 407: 1007-11. PMID 11069180 DOI: 10.1038/35039512 |
0.606 |
|
| 2000 |
Baldursson O, Berger HA, Welsh MJ. Contribution of R domain phosphoserines to the function of CFTR studied in Fischer rat thyroid epithelia. American Journal of Physiology. Lung Cellular and Molecular Physiology. 279: L835-41. PMID 11053017 DOI: 10.1152/Ajplung.2000.279.5.L835 |
0.337 |
|
| 2000 |
Berger AL, Welsh MJ. Differences between cystic fibrosis transmembrane conductance regulator and HisP in the interaction with the adenine ring of ATP. The Journal of Biological Chemistry. 275: 29407-12. PMID 10893239 DOI: 10.1074/Jbc.M004790200 |
0.369 |
|
| 2000 |
Ikuma M, Welsh MJ. Regulation of CFTR Cl- channel gating by ATP binding and hydrolysis. Proceedings of the National Academy of Sciences of the United States of America. 97: 8675-80. PMID 10880569 DOI: 10.1073/Pnas.140220597 |
0.379 |
|
| 2000 |
Askwith CC, Cheng C, Ikuma M, Benson C, Price MP, Welsh MJ. Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels. Neuron. 26: 133-41. PMID 10798398 DOI: 10.1016/S0896-6273(00)81144-7 |
0.723 |
|
| 2000 |
Walters RW, Duan D, Engelhardt JF, Welsh MJ. Incorporation of adeno-associated virus in a calcium phosphate coprecipitate improves gene transfer to airway epithelia in vitro and in vivo. Journal of Virology. 74: 535-40. PMID 10590145 DOI: 10.1128/Jvi.74.1.535-540.2000 |
0.594 |
|
| 1999 |
Walters RW, Welsh MJ. Mechanism by which calcium phosphate coprecipitation enhances adenovirus-mediated gene transfer Gene Therapy. 6: 1845-1850. PMID 10602380 DOI: 10.1038/Sj.Gt.3301020 |
0.6 |
|
| 1999 |
Welsh MJ. Gene transfer for cystic fibrosis. The Journal of Clinical Investigation. 104: 1165-6. PMID 10545512 DOI: 10.1172/Jci8634 |
0.338 |
|
| 1999 |
Eskandari S, Snyder PM, Kreman M, Zampighi GA, Welsh MJ, Wright EM. Number of subunits comprising the epithelial sodium channel. The Journal of Biological Chemistry. 274: 27281-6. PMID 10480948 DOI: 10.1074/Jbc.274.38.27281 |
0.344 |
|
| 1999 |
McCray PB, Zabner J, Jia HP, Welsh MJ, Thorne PS. Efficient killing of inhaled bacteria in DeltaF508 mice: role of airway surface liquid composition. The American Journal of Physiology. 277: L183-90. PMID 10409246 DOI: 10.1152/Ajplung.1999.277.1.L183 |
0.331 |
|
| 1999 |
Welsh MJ, Zabner J. Cationic lipid mediated gene transfer of CFTR: safety of a single administration to the nasal epithelia. Human Gene Therapy. 10: 1559-72. PMID 10395381 DOI: 10.1089/10430349950017897 |
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| 1999 |
Prince LS, Welsh MJ. Effect of subunit composition and Liddle's syndrome mutations on biosynthesis of ENaC. The American Journal of Physiology. 276: C1346-51. PMID 10362597 DOI: 10.1152/Ajpcell.1999.276.6.C1346 |
0.353 |
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| 1999 |
Adams CM, Snyder PM, Welsh MJ. Paradoxical stimulation of a DEG/ENaC channel by amiloride. The Journal of Biological Chemistry. 274: 15500-4. PMID 10336442 DOI: 10.1074/Jbc.274.22.15500 |
0.396 |
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| 1999 |
Travis SM, Conway BA, Zabner J, Smith JJ, Anderson NN, Singh PK, Greenberg EP, Welsh MJ. Activity of abundant antimicrobials of the human airway. American Journal of Respiratory Cell and Molecular Biology. 20: 872-9. PMID 10226057 DOI: 10.1165/Ajrcmb.20.5.3572 |
0.324 |
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| 1999 |
Walters RW, Grunst T, Bergelson JM, Finberg RW, Welsh MJ, Zabner J. Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia. The Journal of Biological Chemistry. 274: 10219-26. PMID 10187807 DOI: 10.1074/Jbc.274.15.10219 |
0.54 |
|
| 1999 |
Adams CM, Price MP, Snyder PM, Welsh MJ. Tetraethylammonium block of the BNC1 channel. Biophysical Journal. 76: 1377-83. PMID 10049320 DOI: 10.1016/S0006-3495(99)77299-1 |
0.383 |
|
| 1999 |
Cotten JF, Welsh MJ. Cystic fibrosis-associated mutations at arginine 347 alter the pore architecture of CFTR. Evidence for disruption of a salt bridge. The Journal of Biological Chemistry. 274: 5429-35. PMID 10026154 DOI: 10.1074/Jbc.274.9.5429 |
0.353 |
|
| 1999 |
McDonald FJ, Yang B, Hrstka RF, Drummond HA, Tarr DE, McCray PB, Stokes JB, Welsh MJ, Williamson RA. Disruption of the beta subunit of the epithelial Na+ channel in mice: hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype. Proceedings of the National Academy of Sciences of the United States of America. 96: 1727-31. PMID 9990092 DOI: 10.1073/Pnas.96.4.1727 |
0.323 |
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| 1999 |
Sheppard DN, Welsh MJ. Structure and function of the CFTR chloride channel. Physiological Reviews. 79: S23-45. PMID 9922375 DOI: 10.1152/Physrev.1999.79.1.S23 |
0.398 |
|
| 1999 |
Snyder PM, Cheng C, Welsh MJ. Chapter 2 Membrane Topology, Subunit Composition, and Stoichiometry of the Epithelial Na+Channel Current Topics in Membranes and Transport. 47: 25-36. DOI: 10.1016/S0070-2161(08)60950-8 |
0.503 |
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| 1998 |
Prince LS, Welsh MJ. Cell surface expression and biosynthesis of epithelial Na+ channels. The Biochemical Journal. 336: 705-10. PMID 9841884 DOI: 10.1042/Bj3360705 |
0.367 |
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| 1998 |
Cotten JF, Welsh MJ. Covalent modification of the nucleotide binding domains of cystic fibrosis transmembrane conductance regulator. The Journal of Biological Chemistry. 273: 31873-9. PMID 9822656 DOI: 10.1074/Jbc.273.48.31873 |
0.392 |
|
| 1998 |
Adams CM, Snyder PM, Price MP, Welsh MJ. Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration. The Journal of Biological Chemistry. 273: 30204-7. PMID 9804777 DOI: 10.1074/Jbc.273.46.30204 |
0.382 |
|
| 1998 |
Zabner J, Smith JJ, Karp PH, Widdicombe JH, Welsh MJ. Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro. Molecular Cell. 2: 397-403. PMID 9774978 DOI: 10.1016/S1097-2765(00)80284-1 |
0.368 |
|
| 1998 |
Cheng C, Prince LS, Snyder PM, Welsh MJ. Assembly of the epithelial Na+ channel evaluated using sucrose gradient sedimentation analysis. The Journal of Biological Chemistry. 273: 22693-700. PMID 9712899 DOI: 10.1074/Jbc.273.35.22693 |
0.37 |
|
| 1998 |
Hall RA, Ostedgaard LS, Premont RT, Blitzer JT, Rahman N, Welsh MJ, Lefkowitz RJ. A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Proceedings of the National Academy of Sciences of the United States of America. 95: 8496-501. PMID 9671706 DOI: 10.1073/Pnas.95.15.8496 |
0.437 |
|
| 1998 |
Fasbender A, Lee JH, Walters RW, Moninger TO, Zabner J, Welsh MJ. Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo. The Journal of Clinical Investigation. 102: 184-93. PMID 9649572 DOI: 10.1172/Jci2732 |
0.587 |
|
| 1998 |
Berger HA, Travis SM, Welsh MJ. Fluoride stimulates cystic fibrosis transmembrane conductance regulator Cl- channel activity. The American Journal of Physiology. 274: L305-12. PMID 9530164 DOI: 10.1152/Ajplung.1998.274.3.L305 |
0.374 |
|
| 1998 |
Adams CM, Anderson MG, Motto DG, Price MP, Johnson WA, Welsh MJ. Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons. The Journal of Cell Biology. 140: 143-52. PMID 9425162 DOI: 10.1083/Jcb.140.1.143 |
0.404 |
|
| 1998 |
Snyder PM, Cheng C, Prince LS, Rogers JC, Welsh MJ. Electrophysiological and biochemical evidence that DEG/ENaC cation channels are composed of nine subunits. The Journal of Biological Chemistry. 273: 681-4. PMID 9422716 DOI: 10.1074/Jbc.273.2.681 |
0.439 |
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| 1997 |
Travis SM, Berger HA, Welsh MJ. Protein phosphatase 2C dephosphorylates and inactivates cystic fibrosis transmembrane conductance regulator. Proceedings of the National Academy of Sciences of the United States of America. 94: 11055-60. PMID 9380758 DOI: 10.1073/Pnas.94.20.11055 |
0.423 |
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| 1997 |
Ishihara H, Welsh MJ. Block by MOPS reveals a conformation change in the CFTR pore produced by ATP hydrolysis. The American Journal of Physiology. 273: C1278-89. PMID 9357772 DOI: 10.1152/Ajpcell.1997.273.4.C1278 |
0.312 |
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| 1997 |
Adams CM, Snyder PM, Welsh MJ. Interactions between subunits of the human epithelial sodium channel. The Journal of Biological Chemistry. 272: 27295-300. PMID 9341177 DOI: 10.1074/Jbc.272.43.27295 |
0.383 |
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| 1997 |
Cotten JF, Welsh MJ. Covalent modification of the regulatory domain irreversibly stimulates cystic fibrosis transmembrane conductance regulator. The Journal of Biological Chemistry. 272: 25617-22. PMID 9325282 DOI: 10.1074/Jbc.272.41.25617 |
0.357 |
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| 1997 |
Winter MC, Welsh MJ. Stimulation of CFTR activity by its phosphorylated R domain. Nature. 389: 294-6. PMID 9305845 DOI: 10.1038/38514 |
0.325 |
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| 1997 |
Sheppard DN, Welsh MJ. Inhibition of the cystic fibrosis transmembrane conductance regulator by ATP-sensitive K+ channel regulators. Annals of the New York Academy of Sciences. 707: 275-84. PMID 9137558 DOI: 10.1111/J.1749-6632.1993.Tb38058.X |
0.376 |
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| 1997 |
Ostedgaard LS, Rich DP, DeBerg LG, Welsh MJ. Association of domains within the cystic fibrosis transmembrane conductance regulator. Biochemistry. 36: 1287-94. PMID 9063876 DOI: 10.1021/Bi962174S |
0.305 |
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| 1996 |
Price MP, Ishihara H, Sheppard DN, Welsh MJ. Function of Xenopus cystic fibrosis transmembrane conductance regulator (CFTR) Cl channels and use of human-Xenopus chimeras to investigate the pore properties of CFTR. The Journal of Biological Chemistry. 271: 25184-91. PMID 8810276 DOI: 10.1074/Jbc.271.41.25184 |
0.424 |
|
| 1996 |
Matsushita K, McCray PB, Sigmund RD, Welsh MJ, Stokes JB. Localization of epithelial sodium channel subunit mRNAs in adult rat lung by in situ hybridization. The American Journal of Physiology. 271: L332-9. PMID 8770073 DOI: 10.1152/Ajplung.1996.271.2.L332 |
0.318 |
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| 1996 |
Cotten JF, Ostedgaard LS, Carson MR, Welsh MJ. Effect of cystic fibrosis-associated mutations in the fourth intracellular loop of cystic fibrosis transmembrane conductance regulator. The Journal of Biological Chemistry. 271: 21279-84. PMID 8702904 DOI: 10.1074/Jbc.271.35.21279 |
0.381 |
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| 1996 |
Sheppard DN, Travis SM, Ishihara H, Welsh MJ. Contribution of proline residues in the membrane-spanning domains of cystic fibrosis transmembrane conductance regulator to chloride channel function. The Journal of Biological Chemistry. 271: 14995-5001. PMID 8663008 DOI: 10.1074/Jbc.271.25.14995 |
0.403 |
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| 1996 |
Price MP, Snyder PM, Welsh MJ. Cloning and expression of a novel human brain Na+ channel. The Journal of Biological Chemistry. 271: 7879-82. PMID 8626462 DOI: 10.1074/Jbc.271.14.7879 |
0.372 |
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| 1996 |
Smith JJ, Travis SM, Greenberg EP, Welsh MJ. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell. 85: 229-36. PMID 8612275 DOI: 10.1016/S0092-8674(00)81099-5 |
0.333 |
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| 1995 |
Volk KA, Sigmund RD, Snyder PM, McDonald FJ, Welsh MJ, Stokes JB. rENaC is the predominant Na+ channel in the apical membrane of the rat renal inner medullary collecting duct. The Journal of Clinical Investigation. 96: 2748-57. PMID 8675644 DOI: 10.1172/Jci118344 |
0.374 |
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| 1995 |
Carson MR, Welsh MJ. Structural and functional similarities between the nucleotide-binding domains of CFTR and GTP-binding proteins. Biophysical Journal. 69: 2443-8. PMID 8599650 DOI: 10.1016/S0006-3495(95)80113-X |
0.343 |
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| 1995 |
McDonald FJ, Welsh MJ. Binding of the proline-rich region of the epithelial Na+ channel to SH3 domains and its association with specific cellular proteins. The Biochemical Journal. 312: 491-7. PMID 8526861 DOI: 10.1042/Bj3120491 |
0.327 |
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| 1995 |
Snyder PM, Price MP, McDonald FJ, Adams CM, Volk KA, Zeiher BG, Stokes JB, Welsh MJ. Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel. Cell. 83: 969-78. PMID 8521520 DOI: 10.1016/0092-8674(95)90212-0 |
0.361 |
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| 1995 |
Hennager DJ, Welsh MJ, DeLisle S. Changes in either cytosolic or nucleoplasmic inositol 1,4,5-trisphosphate levels can control nuclear Ca2+ concentration. The Journal of Biological Chemistry. 270: 4959-62. PMID 7890598 DOI: 10.1074/Jbc.270.10.4959 |
0.742 |
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| 1995 |
McDonald FJ, Price MP, Snyder PM, Welsh MJ. Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel. The American Journal of Physiology. 268: C1157-63. PMID 7762608 DOI: 10.1152/Ajpcell.1995.268.5.C1157 |
0.347 |
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| 1995 |
Welsh MJ, Hoshi T. Molecular cardiology. Ion channels lose the rhythm. Nature. 376: 640. PMID 7651510 DOI: 10.1038/376640A0 |
0.329 |
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| 1995 |
Zeiher BG, Eichwald E, Zabner J, Smith JJ, Puga AP, McCray PB, Capecchi MR, Welsh MJ, Thomas KR. A mouse model for the delta F508 allele of cystic fibrosis. The Journal of Clinical Investigation. 96: 2051-64. PMID 7560099 DOI: 10.1172/Jci118253 |
0.3 |
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| 1995 |
Carson MR, Winter MC, Travis SM, Welsh MJ. Pyrophosphate stimulates wild-type and mutant cystic fibrosis transmembrane conductance regulator Cl- channels. The Journal of Biological Chemistry. 270: 20466-72. PMID 7544788 DOI: 10.1074/Jbc.270.35.20466 |
0.413 |
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| 1995 |
Sheppard DN, Ostedgaard LS, Winter MC, Welsh MJ. Mechanism of dysfunction of two nucleotide binding domain mutations in cystic fibrosis transmembrane conductance regulator that are associated with pancreatic sufficiency. The Embo Journal. 14: 876-83. PMID 7534226 DOI: 10.1002/J.1460-2075.1995.Tb07069.X |
0.418 |
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| 1995 |
Carson MR, Travis SM, Welsh MJ. The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) have distinct functions in controlling channel activity. The Journal of Biological Chemistry. 270: 1711-7. PMID 7530246 DOI: 10.1074/Jbc.270.4.1711 |
0.389 |
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| 1994 |
Smith JJ, Karp PH, Welsh MJ. Defective fluid transport by cystic fibrosis airway epithelia. The Journal of Clinical Investigation. 93: 1307-11. PMID 8132771 DOI: 10.1172/Jci117087 |
0.372 |
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| 1994 |
McDonald FJ, Snyder PM, McCray PB, Welsh MJ. Cloning, expression, and tissue distribution of a human amiloride-sensitive Na+ channel. The American Journal of Physiology. 266: L728-34. PMID 8023962 DOI: 10.1152/Ajplung.1994.266.6.L728 |
0.362 |
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| 1994 |
Carson MR, Travis SM, Winter MC, Sheppard DN, Welsh MJ. Phosphate stimulates CFTR Cl- channels. Biophysical Journal. 67: 1867-75. PMID 7532021 DOI: 10.1016/S0006-3495(94)80668-X |
0.397 |
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| 1994 |
Winter MC, Sheppard DN, Carson MR, Welsh MJ. Effect of ATP concentration on CFTR Cl- channels: a kinetic analysis of channel regulation. Biophysical Journal. 66: 1398-403. PMID 7520292 DOI: 10.1016/S0006-3495(94)80930-0 |
0.365 |
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| 1994 |
Zabner J, Couture LA, Smith AE, Welsh MJ. Correction of cAMP-stimulated fluid secretion in cystic fibrosis airway epithelia: efficiency of adenovirus-mediated gene transfer in vitro. Human Gene Therapy. 5: 585-93. PMID 7519884 DOI: 10.1089/Hum.1994.5.5-585 |
0.341 |
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| 1994 |
Sheppard DN, Carson MR, Ostedgaard LS, Denning GM, Welsh MJ. Expression of cystic fibrosis transmembrane conductance regulator in a model epithelium. The American Journal of Physiology. 266: L405-13. PMID 7513963 DOI: 10.1152/Ajplung.1994.266.4.L405 |
0.412 |
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| 1994 |
Sheppard DN, Ostedgaard LS, Rich DP, Welsh MJ. The amino-terminal portion of CFTR forms a regulated Cl- channel. Cell. 76: 1091-8. PMID 7511062 DOI: 10.1016/0092-8674(94)90385-9 |
0.4 |
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| 1994 |
Zabner J, Petersen DM, Puga AP, Graham SM, Couture LA, Keyes LD, Lukason MJ, George JAS, Gregory RJ, Smith AE, Welsh MJ. Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats Nature Genetics. 6: 75-83. PMID 7511023 DOI: 10.1038/Ng0194-75 |
0.308 |
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| 1994 |
Welsh MJ, Anderson MP, Rich DP, Berger HA, Sheppard DN. The CFTR chloride channel Current Topics in Membranes. 42: 153-171. DOI: 10.1016/S0070-2161(08)60822-9 |
0.612 |
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| 1993 |
Zabner J, Couture LA, Gregory RJ, Graham SM, Smith AE, Welsh MJ. Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis Cell. 75: 207-216. PMID 7691415 DOI: 10.1016/0092-8674(93)80063-K |
0.356 |
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| 1993 |
Delaney SJ, Rich DP, Thomson SA, Hargrave MR, Lovelock PK, Welsh MJ, Wainwright BJ. Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels. Nature Genetics. 4: 426-430. PMID 7691356 DOI: 10.1038/Ng0893-426 |
0.324 |
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| 1993 |
Rich DP, Couture LA, Cardoza LM, Guiggio VM, Armentano D, Espino PC, Hehir K, Welsh MJ, Smith AE, Gregory RJ. Development and analysis of recombinant adenoviruses for gene therapy of cystic fibrosis. Human Gene Therapy. 4: 461-76. PMID 7691187 DOI: 10.1089/Hum.1993.4.4-461 |
0.34 |
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| 1993 |
Carson MR, Welsh MJ. 5'-Adenylylimidodiphosphate does not activate CFTR chloride channels in cell-free patches of membrane American Journal of Physiology - Lung Cellular and Molecular Physiology. 265. PMID 7687826 DOI: 10.1152/Ajplung.1993.265.1.L27 |
0.413 |
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| 1993 |
Welsh MJ, Smith AE. Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis. Cell. 73: 1251-4. PMID 7686820 DOI: 10.1016/0092-8674(93)90353-R |
0.369 |
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| 1993 |
Welsh MJ, Anderson MP. Regulation of the cystic fibrosis transmembrane conductance regulator chloride channel by MgATP. Society of General Physiologists Series. 48: 119-27. PMID 7684867 |
0.563 |
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| 1993 |
Teem JL, Berger HA, Ostedgaard LS, Rich DP, Tsui LC, Welsh MJ. Identification of revertants for the cystic fibrosis delta F508 mutation using STE6-CFTR chimeras in yeast. Cell. 73: 335-46. PMID 7682896 DOI: 10.1016/0092-8674(93)90233-G |
0.572 |
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| 1993 |
Sheppard DN, Rich DP, Ostedgaard LS, Gregory RJ, Smith AE, Welsh MJ. Mutations in CFTR associated with mild-disease-form Cl- channels with altered pore properties. Nature. 362: 160-4. PMID 7680769 DOI: 10.1038/362160A0 |
0.4 |
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| 1993 |
Welsh MJ, Denning GM, Ostedgaard LS, Anderson MP. Dysfunction of CFTR bearing the delta F508 mutation. Journal of Cell Science. Supplement. 17: 235-9. PMID 7511616 |
0.489 |
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| 1993 |
McCray PB, Bettencourt JD, Bastacky J, Denning GM, Welsh MJ. Expression of CFTR and a cAMP-stimulated chloride secretory current in cultured human fetal alveolar epithelial cells Am.J.Respir.Cell Mol.Biol.. 9: 578-585. PMID 7504926 DOI: 10.1165/Ajrcmb/9.6.578 |
0.353 |
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| 1993 |
Sheppard DN, Welsh MJ. Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents. The Journal of General Physiology. 100: 573-91. PMID 1281220 DOI: 10.1085/Jgp.100.4.573 |
0.407 |
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| 1993 |
Welsh MJ, Denning GM, Ostedgaard LS, Anderson MP. Dysfunction of CFTR bearing the F508 mutation Journal of Cell Science. 1993: 235-239. DOI: 10.1242/Jcs.1993.Supplement_17.33 |
0.55 |
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| 1992 |
Welsh MJ, Anderson MP. Correction. Science (New York, N.Y.). 258: 1719. PMID 17831643 DOI: 10.1126/science.258.5089.1719 |
0.501 |
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| 1992 |
Anderson MP, Welsh MJ. Regulation by ATP and ADP of CFTR chloride channels that contain mutant nucleotide-binding domains. Science (New York, N.Y.). 257: 1701-4. PMID 1382316 DOI: 10.1126/Science.1382316 |
0.603 |
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| 1992 |
Denning GM, Anderson MP, Amara JF, Marshall J, Smith AE, Welsh MJ. Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive. Nature. 358: 761-4. PMID 1380673 DOI: 10.1038/358761A0 |
0.583 |
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| 1992 |
Denning GM, Ostedgaard LS, Welsh MJ. Abnormal localization of cystic fibrosis transmembrane conductance regulator in primary cultures of cystic fibrosis airway epithelia. The Journal of Cell Biology. 118: 551-9. PMID 1379244 DOI: 10.1083/Jcb.118.3.551 |
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| 1992 |
Welsh MJ, Anderson MP, Rich DP, Berger HA, Denning GM, Ostedgaard LS, Sheppard DN, Cheng SH, Gregory RJ, Smith AE. Cystic fibrosis transmembrane conductance regulator: a chloride channel with novel regulation. Neuron. 8: 821-9. PMID 1375035 DOI: 10.1016/0896-6273(92)90196-K |
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| 1992 |
Denning GM, Ostedgaard LS, Cheng SH, Smith AE, Welsh MJ. Localization of cystic fibrosis transmembrane conductance regulator in chloride secretory epithelia. The Journal of Clinical Investigation. 89: 339-49. PMID 1370301 DOI: 10.1172/Jci115582 |
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| 1992 |
Ostedgaard LS, Shasby DM, Welsh MJ. Staphylococcus aureus alpha-toxin permeabilizes the basolateral membrane of a Cl(-)-secreting epithelium. The American Journal of Physiology. 263: L104-12. PMID 1322049 DOI: 10.1152/Ajplung.1992.263.1.L104 |
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| 1992 |
Anderson MP, Sheppard DN, Berger HA, Welsh MJ. Chloride channels in the apical membrane of normal and cystic fibrosis airway and intestinal epithelia. The American Journal of Physiology. 263: L1-14. PMID 1322048 DOI: 10.1152/Ajplung.1992.263.1.L1 |
0.607 |
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| 1992 |
Smith JJ, Welsh MJ. cAMP stimulates bicarbonate secretion across normal, but not cystic fibrosis airway epithelia Journal of Clinical Investigation. 89: 1148-1153. PMID 1313448 DOI: 10.1172/Jci115696 |
0.374 |
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| 1991 |
Anderson MP, Berger HA, Rich DP, Gregory RJ, Smith AE, Welsh MJ. Nucleoside triphosphates are required to open the CFTR chloride channel. Cell. 67: 775-84. PMID 1718606 DOI: 10.1016/0092-8674(91)90072-7 |
0.594 |
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| 1991 |
Berger HA, Anderson MP, Gregory RJ, Thompson S, Howard PW, Maurer RA, Mulligan R, Smith AE, Welsh MJ. Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel. The Journal of Clinical Investigation. 88: 1422-31. PMID 1717515 DOI: 10.1172/Jci115450 |
0.616 |
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| 1991 |
Rich DP, Gregory RJ, Anderson MP, Manavalan P, Smith AE, Welsh MJ. Effect of deleting the R domain on CFTR-generated chloride channels. Science (New York, N.Y.). 253: 205-7. PMID 1712985 DOI: 10.1126/Science.1712985 |
0.549 |
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| 1991 |
Anderson MP, Gregory RJ, Thompson S, Souza DW, Paul S, Mulligan RC, Smith AE, Welsh MJ. Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science (New York, N.Y.). 253: 202-5. PMID 1712984 DOI: 10.1126/Science.1712984 |
0.604 |
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| 1991 |
Gregory RJ, Rich DP, Cheng SH, Souza DW, Paul S, Manavalan P, Anderson MP, Welsh MJ, Smith AE. Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2. Molecular and Cellular Biology. 11: 3886-93. PMID 1712898 DOI: 10.1128/Mcb.11.8.3886 |
0.507 |
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| 1991 |
Anderson MP, Welsh MJ. Calcium and cAMP activate different chloride channels in the apical membrane of normal and cystic fibrosis epithelia. Proceedings of the National Academy of Sciences of the United States of America. 88: 6003-7. PMID 1712478 DOI: 10.1073/Pnas.88.14.6003 |
0.6 |
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| 1991 |
Berger HA, Welsh MJ. Electrolyte transport in the lungs. Hospital Practice. 26: 53-59. PMID 1706347 DOI: 10.1080/21548331.1991.11707712 |
0.319 |
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| 1991 |
Anderson MP, Rich DP, Gregory RJ, Smith AE, Welsh MJ. Generation of cAMP-activated chloride currents by expression of CFTR. Science (New York, N.Y.). 251: 679-82. PMID 1704151 DOI: 10.1126/Science.1704151 |
0.614 |
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| 1991 |
Cheng S, Rich D, Marshall J, Gregory R, Welsh M, Smith A. Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel Trends in Cell Biology. 1: 152. DOI: 10.1016/0092-8674(91)90446-6 |
0.351 |
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| 1990 |
Welsh MJ, Li M, McCann JD. Activation of normal and cystic fibrosis Cl- channels by voltage, temperature, and trypsin. The Journal of Clinical Investigation. 84: 2002-7. PMID 2556452 DOI: 10.1172/Jci114391 |
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| 1990 |
McCann JD, Li M, Welsh MJ. Identification and regulation of whole-cell chloride currents in airway epithelium. The Journal of General Physiology. 94: 1015-36. PMID 2482326 DOI: 10.1085/Jgp.94.6.1015 |
0.398 |
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| 1990 |
Anderson MP, Welsh MJ. Isoproterenol, cAMP, and bradykinin stimulate diacylglycerol production in airway epithelium. The American Journal of Physiology. 258: L294-300. PMID 2163209 DOI: 10.1152/Ajplung.1990.258.6.L294 |
0.54 |
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| 1990 |
Krause KH, Welsh MJ. Voltage-dependent and Ca2(+)-activated ion channels in human neutrophils. The Journal of Clinical Investigation. 85: 491-8. PMID 2153708 DOI: 10.1172/Jci114464 |
0.363 |
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| 1990 |
Clancy JP, McCann JD, Welsh MJ. Evidence that Ca2(+)-dependent activation of airway epithelia Cl- channels is not dependent on phosphorylation. The American Journal of Physiology. 259: L410-4. PMID 1701978 DOI: 10.1152/Ajplung.1990.259.6.L410 |
0.363 |
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| 1990 |
Gregory RJ, Cheng SH, Rich DP, Marshall J, Paul S, Hehir K, Ostedgaard L, Klinger KW, Welsh MJ, Smith AE. Expression and characterization of the cystic fibrosis transmembrane conductance regulator. Nature. 347: 382-6. PMID 1699127 DOI: 10.1038/347382A0 |
0.395 |
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| 1990 |
Rich DP, Anderson MP, Gregory RJ, Cheng SH, Paul S, Jefferson DM, McCann JD, Klinger KW, Smith AE, Welsh MJ. Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells. Nature. 347: 358-63. PMID 1699126 DOI: 10.1038/347358A0 |
0.613 |
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| 1990 |
Anderson MP, Welsh MJ. Fatty acids inhibit apical membrane chloride channels in airway epithelia. Proceedings of the National Academy of Sciences of the United States of America. 87: 7334-8. PMID 1698296 DOI: 10.1073/Pnas.87.18.7334 |
0.583 |
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| 1990 |
Li M, McCann JD, Welsh MJ. Apical membrane Cl- channels in airway epithelia: anion selectivity and effect of an inhibitor. The American Journal of Physiology. 259: C295-301. PMID 1696430 DOI: 10.1152/Ajpcell.1990.259.2.C295 |
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| 1990 |
Welsh MJ. Abnormal regulation of ion channels in cystic fibrosis epithelia Faseb Journal. 4: 2718-2725. PMID 1695593 DOI: 10.1096/Fasebj.4.10.1695593 |
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| 1990 |
Smith JJ, McCann JD, Welsh MJ. Bradykinin stimulates airway epithelial Cl- secretion via two second messenger pathways. American Journal of Physiology-Lung Cellular and Molecular Physiology. 258. PMID 1694407 DOI: 10.1152/Ajplung.1990.258.6.L369 |
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| 1990 |
McCann JD, Welsh MJ. Basolateral K+ channels in airway epithelia. II. Role in Cl- secretion and evidence for two types of K+ channel. The American Journal of Physiology. 258: L343-8. PMID 1694405 DOI: 10.1152/Ajplung.1990.258.6.L343 |
0.386 |
|
| 1990 |
McCann JD, Matsuda J, Garcia M, Kaczorowski G, Welsh MJ. Basolateral K+ channels in airway epithelia. I. Regulation by Ca2+ and block by charybdotoxin. The American Journal of Physiology. 258: L334-42. PMID 1694404 DOI: 10.1152/Ajplung.1990.258.6.L334 |
0.36 |
|
| 1990 |
Clancy JP, McCann JD, Li M, Welsh MJ. Calcium-dependent regulation of airway epithelial chloride channels. The American Journal of Physiology. 258: L25-32. PMID 1689551 DOI: 10.1152/Ajplung.1990.258.2.L25 |
0.372 |
|
| 1990 |
Welsh MJ, McCann JD, Li M, Clancy JP, Anderson MP. In Reply: Chloride Channels in Cystic Fibrosis Patients Science. 247: 222-222. DOI: 10.1126/Science.247.4939.222-B |
0.577 |
|
| 1989 |
Welsh MJ, Li M, McCann JD, Clancy JP, Anderson MP. Phosphorylation-dependent regulation of apical membrane chloride channels in normal and cystic fibrosis airway epithelium. Annals of the New York Academy of Sciences. 574: 44-51. PMID 2561330 DOI: 10.1111/J.1749-6632.1989.Tb25131.X |
0.6 |
|
| 1988 |
Gruenert DC, Basbaum CB, Welsh MJ, Li M, Finkbeiner WE, Nadel JA. Characterization of human tracheal epithelial cells transformed by an origin-defective simian virus 40. Proceedings of the National Academy of Sciences of the United States of America. 85: 5951-5. PMID 2457904 DOI: 10.1073/Pnas.85.16.5951 |
0.348 |
|
| 1988 |
Li M, McCann JD, Liedtke CM, Nairn AC, Greengard P, Welsh MJ. Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium. Nature. 331: 358-60. PMID 2448645 DOI: 10.1038/331358A0 |
0.428 |
|
| 1987 |
Welsh MJ. Effect of phorbol ester and calcium ionophore on chloride secretion in canine tracheal epithelium American Journal of Physiology - Cell Physiology. 253. PMID 2827498 DOI: 10.1152/Ajpcell.1987.253.6.C828 |
0.301 |
|
| 1986 |
Welsh MJ. Single apical membrane anion channels in primary cultures of canine tracheal epithelium PflüGers Archiv European Journal of Physiology. 407. PMID 2434914 DOI: 10.1007/Bf00584940 |
0.401 |
|
| 1986 |
Welsh MJ, Liedtke CM. Chloride and potassium channels in cystic fibrosis airway epithelia. Nature. 322: 467-70. PMID 2426598 DOI: 10.1038/322467A0 |
0.32 |
|
| 1986 |
Welsh MJ. An apical-membrane chloride channel in human tracheal epithelium Science. 232: 1648-1650. PMID 2424085 DOI: 10.1126/Science.2424085 |
0.423 |
|
| 1986 |
Welsh MJ, McCann JD. Intracellular calcium regulates basolateral potassium channels in a chloride-secreting epithelium. Proceedings of the National Academy of Sciences of the United States of America. 82: 8823-6. PMID 2417229 DOI: 10.1073/Pnas.82.24.8823 |
0.32 |
|
| 1985 |
Welsh MJ. Ion transport by primary cultures of canine tracheal epithelium: Methodology, morphology, and electrophysiology The Journal of Membrane Biology. 88: 149-163. PMID 4093958 DOI: 10.1007/Bf01868429 |
0.321 |
|
| 1985 |
Widdicombe JH, Welsh MJ, Finkbeiner WE. Cystic fibrosis decreases the apical membrane chloride permeability of monolayers cultured from cells of tracheal epithelium. Proceedings of the National Academy of Sciences of the United States of America. 82: 6167-71. PMID 3862125 DOI: 10.1073/Pnas.82.18.6167 |
0.305 |
|
| 1985 |
Welsh MJ. Basolateral membrane potassium conductance is independent of sodium pump activity and membrane voltage in canine tracheal epithelium The Journal of Membrane Biology. 84: 25-33. PMID 2987501 DOI: 10.1007/Bf01871645 |
0.305 |
|
| 1984 |
Welsh MJ. Anthracene-9-carboxylic acid inhibits an apical membrane, chloride conductance in canine tracheal epithelium The Journal of Membrane Biology. 78: 61-71. PMID 6708094 DOI: 10.1007/Bf01872533 |
0.301 |
|
| 1983 |
Welsh MJ, Smith PL, Frizzell RA. Intracellular chloride activities in the isolated perfused shark rectal gland. The American Journal of Physiology. 245: F640-4. PMID 6638184 DOI: 10.1152/Ajprenal.1983.245.5.F640 |
0.303 |
|
| 1981 |
Tash JS, Welsh MJ, Means AR. Regulation of protein kinase inhibitor by follicle-stimulating hormone in Sertoli cells in vitro. Endocrinology. 108: 427-34. PMID 6256152 DOI: 10.1210/Endo-108-2-427 |
0.392 |
|
| 1980 |
Tash JS, Welsh MJ, Means AR. Protein inhibitor of cAMP-dependent protein kinase: production and characterization of antibodies and intracellular localization. Cell. 21: 57-65. PMID 6250718 DOI: 10.1016/0092-8674(80)90114-2 |
0.394 |
|
| 1980 |
Means AR, Welsh MJ, Dedman JR, Tash JS. FSH stimulation of protein kinase inhibitor: regulation of cellular metabolism. Advances in Cyclic Nucleotide Research. 12: 373-85. PMID 6250369 |
0.374 |
|
| 1980 |
Means AR, Dedman JR, Tash JS, Tindall DJ, van Sickle M, Welsh MJ. Regulation of the testis sertoli cell by follicle stimulating hormone. Annual Review of Physiology. 42: 59-70. PMID 6157356 DOI: 10.1146/Annurev.Ph.42.030180.000423 |
0.388 |
|
| 1979 |
Welsh MJ, Dedman JR, Brinkley BR, Means AR. Tubulin and calmodulin. Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus. The Journal of Cell Biology. 81: 624-34. PMID 379022 DOI: 10.1083/Jcb.81.3.624 |
0.386 |
|
| 1978 |
Welsh MJ, Dedman JR, Brinkley BR, Means AR. Calcium-dependent regulator protein: localization in mitotic apparatus of eukaryotic cells. Proceedings of the National Academy of Sciences of the United States of America. 75: 1867-71. PMID 273915 DOI: 10.1073/Pnas.75.4.1867 |
0.401 |
|
| 1978 |
Dedman JR, Welsh MJ, Means AR. Ca2+-dependent regulator. Production and characterization of a monospecific antibody. The Journal of Biological Chemistry. 253: 7515-21. PMID 212426 |
0.386 |
|
| 1978 |
Means AR, Dedman JR, Tindall DJ, Welsh MJ. Hormonal regulation of Sertoli cells International Journal of Andrology. DOI: 10.1111/J.1365-2605.1978.Tb00498.X |
0.43 |
|
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