| Year |
Citation |
Score |
| 2024 |
Wang W, Zhou Y, Wang J, Zhang S, Ozes A, Gao H, Fang F, Wang Y, Chu X, Liu Y, Wan J, Mitra AK, O'Hagan HM, Nephew KP. Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2. Molecular Cancer Therapeutics. PMID 39039946 DOI: 10.1158/1535-7163.MCT-23-0314 |
0.342 |
|
| 2024 |
Williams I, DeHart H, O'Malley M, Walker B, Ulhaskumar V, Ray H, Delaney JR, Nephew KP, Carpenter RL. MYC and HSF1 Cooperate to Drive PLK1 inhibitor Sensitivity in High Grade Serous Ovarian Cancer. Biorxiv : the Preprint Server For Biology. PMID 38915574 DOI: 10.1101/2024.06.11.598486 |
0.346 |
|
| 2024 |
Fang Y, Xiao X, Wang J, Dasari S, Pepin D, Nephew KP, Zamarin D, Mitra AK. Cancer associated fibroblasts serve as an ovarian cancer stem cell niche through noncanonical Wnt5a signaling. Npj Precision Oncology. 8: 7. PMID 38191909 DOI: 10.1038/s41698-023-00495-5 |
0.325 |
|
| 2023 |
Khatpe AS, Dirks R, Bhat-Nakshatri P, Mang H, Batic K, Swiezy S, Olson J, Rao X, Wang Y, Tanaka H, Liu S, Wan J, Chen D, Liu Y, Fang F, ... ... Nephew K, et al. TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer. Cancer Research. 83: 1345-1360. PMID 37057595 DOI: 10.1158/0008-5472.CAN-22-3667 |
0.581 |
|
| 2023 |
Li S, Zeng H, Fan J, Wang F, Xu C, Li Y, Tu J, Nephew KP, Long X. Glutamine metabolism in breast cancer and possible therapeutic targets. Biochemical Pharmacology. 115464. PMID 36849062 DOI: 10.1016/j.bcp.2023.115464 |
0.565 |
|
| 2022 |
Sriramkumar S, Metcalfe TX, Lai T, Zong X, Fang F, O'Hagan HM, Nephew KP. Single-cell analysis of a high-grade serous ovarian cancer cell line reveals transcriptomic changes and cell subpopulations sensitive to epigenetic combination treatment. Plos One. 17: e0271584. PMID 35921335 DOI: 10.1371/journal.pone.0271584 |
0.334 |
|
| 2021 |
Burks HE, Matossian MD, Rhodes LV, Phamduy T, Elliott S, Buechlein A, Rusch DB, Miller DFB, Nephew KP, Chrisey D, Collins-Burow BM, Burow ME. ZEB2 regulates endocrine therapy sensitivity and metastasis in luminal a breast cancer cells through a non-canonical mechanism. Breast Cancer Research and Treatment. PMID 34231077 DOI: 10.1007/s10549-021-06256-x |
0.313 |
|
| 2021 |
Matossian MD, Hoang VT, Burks HE, La J, Elliott S, Brock C, Rusch DB, Buechlein A, Nephew KP, Bhatt A, Cavanaugh JE, Flaherty PT, Collins-Burow BM, Burow ME. Constitutive activation of MEK5 promotes a mesenchymal and migratory cell phenotype in triple negative breast cancer. Oncoscience. 8: 64-71. PMID 34026925 DOI: 10.18632/oncoscience.535 |
0.315 |
|
| 2021 |
Wang W, Fang F, Ozes A, Nephew KP. Targeting Ovarian Cancer Stem Cells by Dual Inhibition of HOTAIR and DNA Methylation. Molecular Cancer Therapeutics. PMID 33785648 DOI: 10.1158/1535-7163.MCT-20-0826 |
0.317 |
|
| 2020 |
Kim O, Park EY, Kwon SY, Shin S, Emerson RE, Shin YH, DeMayo FJ, Lydon JP, Coffey DM, Hawkins SM, Quilliam LA, Cheon DJ, Fernández FM, Nephew KP, Karpf AR, et al. Targeting progesterone signaling prevents metastatic ovarian cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 33262282 DOI: 10.1073/pnas.2013595117 |
0.311 |
|
| 2020 |
Hoang VT, Matossian MD, Ucar DA, Elliott S, La J, Wright MK, Burks HE, Perles A, Hossain F, King CT, Browning VE, Bursavich J, Fang F, Del Valle L, Bhatt AB, ... ... Nephew KP, et al. ERK5 Is Required for Tumor Growth and Maintenance Through Regulation of the Extracellular Matrix in Triple Negative Breast Cancer. Frontiers in Oncology. 10: 1164. PMID 32850332 DOI: 10.3389/Fonc.2020.01164 |
0.423 |
|
| 2020 |
Zong X, Wang W, Ozes A, Fang F, Sandusky GE, Nephew KP. EZH2-mediated Downregulation of the Tumor Suppressor DAB2IP Maintains Ovarian Cancer Stem Cells. Cancer Research. PMID 32816909 DOI: 10.1158/0008-5472.Can-20-0458 |
0.424 |
|
| 2020 |
Sriramkumar S, Matthews TD, Ghobashi AH, Miller SA, VanderVere-Carozza PS, Pawelczak KS, Nephew KP, Turchi JJ, O'Hagan HM. Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A is Mediated by Replication Protein A in Ovarian Cancer. Molecular Cancer Research : McR. PMID 32801161 DOI: 10.1158/1541-7786.Mcr-20-0396 |
0.33 |
|
| 2020 |
Matossian MD, Burks HE, Elliott S, Hoang VT, Zuercher WJ, Wells C, Drewry DH, Kapadia N, Chang T, Yan T, Windsor GO, Nguyen K, Fang F, Nephew KP, Buechlein A, et al. A novel screening approach comparing kinase activity of small molecule inhibitors with similar molecular structures and distinct biologic effects in triple-negative breast cancer to identify targetable signaling pathways. Anti-Cancer Drugs. 31: 759-775. PMID 32796402 DOI: 10.1097/Cad.0000000000000962 |
0.398 |
|
| 2020 |
Kim O, Park EY, Klinkebiel DL, Pack SD, Shin YH, Abdullaev Z, Emerson RE, Coffey DM, Kwon SY, Creighton CJ, Kwon S, Chang EC, Chiang T, Yatsenko AN, Chien J, ... ... Nephew KP, et al. In vivo modeling of metastatic human high-grade serous ovarian cancer in mice. Plos Genetics. 16: e1008808. PMID 32497036 DOI: 10.1371/Journal.Pgen.1008808 |
0.386 |
|
| 2020 |
Matei D, Nephew KP. Epigenetic Attire in Ovarian Cancer: The Emperor's New Clothes. Cancer Research. PMID 32381656 DOI: 10.1158/0008-5472.Can-19-3837 |
0.436 |
|
| 2020 |
Muralikrishnan V, Hurley TD, Nephew KP. Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic Malignancies. Cancers. 12. PMID 32295073 DOI: 10.3390/Cancers12040961 |
0.379 |
|
| 2020 |
Birrer MJ, Wenzel L, Miller A, Lankes H, Ramirez N, Parmigiani G, Mok S, Nephew K, Conrads T, Coukos G, Maxwell GL, Fulci G, Scroggins M. Abstract IA06: The Long-Term Ovarian Cancer Survivor Project: A Department of Defense initiative Clinical Cancer Research. 26. DOI: 10.1158/1557-3265.Ovca19-Ia06 |
0.38 |
|
| 2020 |
Klymenko Y, Nephew KP. Abstract B63: Lysophosphatidic acid as a mediator of ovarian cancer cell stemness Clinical Cancer Research. 26. DOI: 10.1158/1557-3265.Ovca19-B63 |
0.448 |
|
| 2020 |
Zong X, Ozes A, Wang W, Nephew KP. Abstract A81: Targeting EZH2/DAB2IP/Wnt axis in ovarian cancer stem cells Clinical Cancer Research. 26. DOI: 10.1158/1557-3265.Ovca19-A81 |
0.467 |
|
| 2020 |
Fang F, Bhat-Nakshatri P, Anjanappa M, Rusch D, Buechlein A, Miller D, Nephew KP, Nakshatri H. Abstract P2-06-01: Intrinsic transcriptomic differences of luminal progenitors and mature luminal cells of the normal breast Cancer Research. DOI: 10.1158/1538-7445.Sabcs19-P2-06-01 |
0.336 |
|
| 2020 |
Zong X, Ozes A, Wang W, Fang F, Nephew KP. Abstract 498: Targeting EZH2/DAB2IP/C-JUN axis in ovarian cancer stem cells Cancer Research. 80: 498-498. DOI: 10.1158/1538-7445.Am2020-498 |
0.459 |
|
| 2019 |
Cai H, Ao Z, Wu Z, Nunez A, Jiang L, Carpenter RL, Nephew KP, Guo F. Profiling Cell-Matrix Adhesion Using Digitalized Acoustic Streaming. Analytical Chemistry. PMID 31880433 DOI: 10.1021/Acs.Analchem.9B05065 |
0.331 |
|
| 2019 |
Oza AM, Matulonis UA, Alvarez Secord A, Nemunaitis J, Roman LD, Blagden SP, Banerjee S, McGuire WP, Ghamande S, Birrer MJ, Fleming GF, Markham MJ, Hirte HW, Provencher DM, Basu B, ... ... Nephew KP, et al. A randomized phase 2 trial of epigenetic priming with guadecitabine and carboplatin in platinum-resistant, recurrent ovarian cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31831561 DOI: 10.1158/1078-0432.Ccr-19-1638 |
0.345 |
|
| 2019 |
Demas DM, Demo S, Fallah Y, Clarke R, Nephew KP, Althouse S, Sandusky G, He W, Shajahan-Haq AN. Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer. Frontiers in Oncology. 9: 686. PMID 31428575 DOI: 10.3389/Fonc.2019.00686 |
0.423 |
|
| 2019 |
Zong X, Nephew KP. Ovarian Cancer Stem Cells: Role in Metastasis and Opportunity for Therapeutic Targeting. Cancers. 11. PMID 31277278 DOI: 10.3390/Cancers11070934 |
0.398 |
|
| 2019 |
Milevskiy MJG, Gujral U, Del Lama Marques C, Stone A, Northwood K, Burke LJ, Gee JMW, Nephew K, Clark S, Brown MA. MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER+ breast cancer. British Journal of Cancer. PMID 30783203 DOI: 10.1038/S41416-019-0395-8 |
0.398 |
|
| 2019 |
Pulliam N, Tang J, Wang W, Fang F, Sood R, O'Hagan HM, Miller KD, Clarke R, Nephew KP. Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 Mediates Antiestrogen Resistance in Human Breast Cancer Cells. Cancers. 11. PMID 30621214 DOI: 10.3390/Cancers11010043 |
0.427 |
|
| 2019 |
Wang W, Fang F, Ozes A, Nephew KP. Abstract 3685: HOTAIR regulation and functionality in ovarian cancer stem cells Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3685 |
0.385 |
|
| 2019 |
Dirks RC, Olson J, Rao X, Liu Y, Nephew K, Fang F, Nakshatri H. Tonsoku-Like Protein Facilitates Chromatin Transcription Complex (TONSL-FACT): Illuminating Unsuspected Culprits in Breast Cancer Initiation Journal of the American College of Surgeons. 229: S41. DOI: 10.1016/J.Jamcollsurg.2019.08.104 |
0.574 |
|
| 2018 |
Stack MS, Nephew KP, Burdette JE, K Mitra A. The Tumor Microenvironment of High Grade Serous Ovarian Cancer. Cancers. 11. PMID 30587822 DOI: 10.3390/Cancers11010021 |
0.382 |
|
| 2018 |
Wang Y, Zong X, Mitra S, Mitra AK, Matei D, Nephew KP. IL-6 mediates platinum-induced enrichment of ovarian cancer stem cells. Jci Insight. 3. PMID 30518684 DOI: 10.1172/Jci.Insight.122360 |
0.303 |
|
| 2018 |
Klymenko Y, Nephew KP. Epigenetic Crosstalk between the Tumor Microenvironment and Ovarian Cancer Cells: A Therapeutic Road Less Traveled. Cancers. 10. PMID 30200265 DOI: 10.3390/Cancers10090295 |
0.415 |
|
| 2018 |
Cai Q, Fan Q, Buechlein A, Miller D, Nephew KP, Liu S, Wan J, Xu Y. Changes in mRNA/protein expression and signaling pathways in in vivo passaged mouse ovarian cancer cells. Plos One. 13: e0197404. PMID 29927933 DOI: 10.1371/Journal.Pone.0197404 |
0.417 |
|
| 2018 |
Tang J, Pulliam N, Ozes A, Buechlein A, Ding N, Rusch D, Keer H, O'Hagan H, Stack MS, Nephew KP. EPIGENETIC TARGETING OF ADIPOCYTES INHIBITS HIGH-GRADE SEROUS OVARIAN CANCER CELL MIGRATION AND INVASION. Molecular Cancer Research : McR. PMID 29759990 DOI: 10.1158/1541-7786.Mcr-17-0406 |
0.426 |
|
| 2018 |
Pulliam N, Fang F, Ozes AR, Tang J, Adewuyi A, Keer HN, Lyons JF, Baylin SB, Matei D, Nakshatri H, Rassool FV, Miller KD, Nephew KP. An Effective Epigenetic-PARP inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA-mutations. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29615458 DOI: 10.1158/1078-0432.Ccr-18-0204 |
0.398 |
|
| 2018 |
Özeş AR, Pulliam N, Ertosun MG, Yılmaz Ö, Tang J, Çopuroğlu E, Matei D, Özeş ON, Nephew KP. Protein kinase A-mediated phosphorylation regulates STAT3 activation and oncogenic EZH2 activity. Oncogene. PMID 29576612 DOI: 10.1038/S41388-018-0218-Z |
0.361 |
|
| 2018 |
Matei D, Ghamande S, Roman LD, Alvarez Secord A, Nemunaitis J, Markham MJ, Nephew KP, Jueliger S, Oganesian A, Naim S, Su XY, Keer HN, Azab M, Fleming G. A Phase 1 Clinical Trial of Guadecitabine and Carboplatin In Platinum-Resistant, Recurrent Ovarian Cancer: Clinical, Pharmacokinetic And Pharmacodynamic Analyses. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29500276 DOI: 10.1158/1078-0432.Ccr-17-3055 |
0.36 |
|
| 2018 |
Zong X, Ozes AR, Nephew KP. Abstract B07: Targeting DAB2IP in ovarian cancer stem cells Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Ovca17-B07 |
0.44 |
|
| 2017 |
Chovanec M, Taza F, Kalra M, Hahn N, Nephew KP, Spinella MJ, Albany C. Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review. Targeted Oncology. PMID 29230671 DOI: 10.1007/S11523-017-0546-X |
0.313 |
|
| 2017 |
Fang F, Cardenas H, Huang H, Jiang G, Perkins SM, Zhang C, Keer HN, Liu Y, Nephew KP, Matei D. Genomic and Epigenomic Signatures in Ovarian Cancer Associated with Re-sensitization to Platinum Drugs. Cancer Research. PMID 29229600 DOI: 10.1158/0008-5472.Can-17-1492 |
0.403 |
|
| 2017 |
Fan Q, Cai Q, Li P, Wang W, Wang J, Gerry E, Wang TL, Shih IM, Nephew KP, Xu Y. The novel ZIP4 regulation and its role in ovarian cancer. Oncotarget. 8: 90090-90107. PMID 29163813 DOI: 10.18632/Oncotarget.21435 |
0.457 |
|
| 2017 |
MacKay HJ, Levine DA, Bae-Jump VL, Bell DW, McAlpine JN, Santin A, Fleming GF, Mutch DG, Nephew KP, Wentzensen N, Goodfellow PJ, Dorigo O, Nijman HW, Broaddus R, Kohn EC. Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials. Oncotarget. 8: 84579-84594. PMID 29137450 DOI: 10.18632/Oncotarget.19961 |
0.375 |
|
| 2017 |
Özeş AR, Wang Y, Zong X, Fang F, Pilrose J, Nephew KP. Therapeutic targeting using tumor specific peptides inhibits long non-coding RNA HOTAIR activity in ovarian and breast cancer. Scientific Reports. 7: 894. PMID 28420874 DOI: 10.1038/S41598-017-00966-3 |
0.402 |
|
| 2017 |
Özeş AR, Wang Y, Fang F, Nephew KP. Abstract AP14: THERAPEUTIC TARGETING USING TUMOR SPECIFIC PEPTIDES INHIBITS LONG NON–CODING RNA HOTAIR ONCOGENIC ACTIVITY IN OVARIAN CANCER Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Ovcasymp16-Ap14 |
0.432 |
|
| 2017 |
Pulliam N, Taverna P, Lyons J, Nephew KP. Abstract 4675: Novel combination therapy of DNA methyltransferase inhibitor guadecitabine (SGI-110) and PARP inhibitor talazoparib (BMN-673) for BRCA-proficient high-grade serous ovarian cancer Cancer Research. 77: 4675-4675. DOI: 10.1158/1538-7445.Am2017-4675 |
0.452 |
|
| 2017 |
Tang J, Fang F, Buechlein A, Taverna P, Nephew KP. Abstract 4347: Epigenetic targeting of DNMT1 in adipocytes inhibits high-grade serous ovarian cancer cell migration and invasion through TIMP3 upregulation Cancer Research. 77: 4347-4347. DOI: 10.1158/1538-7445.Am2017-4347 |
0.453 |
|
| 2016 |
Conger AK, Martin EC, Yan TJ, Rhodes LV, Hoang VT, La J, Anbalagan M, Burks HE, Rowan BG, Nephew KP, Collins-Burow BM, Burow ME. Argonaute 2 Expression Correlates with a Luminal B Breast Cancer Subtype and Induces Estrogen Receptor Alpha Isoform Variation. Non-Coding Rna. 2. PMID 29657266 DOI: 10.3390/Ncrna2030008 |
0.429 |
|
| 2016 |
Chae H, Lee S, Nephew KP, Kim S. Subtype-specific CpG island shore methylation and mutation patterns in 30 breast cancer cell lines. Bmc Systems Biology. 10: 116. PMID 28155687 DOI: 10.1186/S12918-016-0356-2 |
0.429 |
|
| 2016 |
Martin EC, Conger AK, Yan TJ, Hoang VT, Miller DF, Buechlein A, Rusch DB, Nephew KP, Collins-Burow BM, Burow ME. MicroRNA-335-5p and -3p Synergize to Inhibit Estrogen Receptor Alpha Expression and Promote Tamoxifen Resistance. Febs Letters. PMID 28008602 DOI: 10.1002/1873-3468.12538 |
0.393 |
|
| 2016 |
Cardenas H, Zhao J, Vieth E, Nephew KP, Matei D. EZH2 inhibition promotes epithelial-to-mesenchymal transition in ovarian cancer cells. Oncotarget. PMID 27563817 DOI: 10.18632/Oncotarget.11497 |
0.409 |
|
| 2016 |
Chae H, Lee S, Seo S, Jung D, Chang H, Nephew KP, Kim S. BioVLAB-mCpG-SNP-EXPRESS : A System for Multi-level and Multi-perspective Analysis and Exploration of DNA Methylation, Sequence Variation (SNPs), and Gene Expression from Multi-omics Data. Methods (San Diego, Calif.). PMID 27477210 DOI: 10.1016/J.Ymeth.2016.07.019 |
0.331 |
|
| 2016 |
Milevskiy MJ, Al-Ejeh F, Saunus JM, Northwood KS, Bailey PJ, Betts JA, McCart Reed AE, Nephew KP, Stone A, Gee JM, Dowhan DH, Dray E, Shewan AM, French JD, Edwards SL, et al. Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer. Human Molecular Genetics. PMID 27378691 DOI: 10.1093/Hmg/Ddw177 |
0.433 |
|
| 2016 |
de Leon M, Cardenas H, Vieth E, Emerson R, Segar M, Liu Y, Nephew K, Matei D. Transmembrane protein 88 (TMEM88) promoter hypomethylation is associated with platinum resistance in ovarian cancer. Gynecologic Oncology. PMID 27374141 DOI: 10.1016/J.Ygyno.2016.06.017 |
0.412 |
|
| 2016 |
Haley J, Tomar S, Pulliam N, Xiong S, Perkins SM, Karpf AR, Mitra S, Nephew KP, Mitra AK. Functional characterization of a panel of high-grade serous ovarian cancer cell lines as representative experimental models of the disease. Oncotarget. PMID 27147568 DOI: 10.18632/Oncotarget.9053 |
0.419 |
|
| 2016 |
Özeş AR, Miller DF, Özeş ON, Fang F, Liu Y, Matei D, Huang T, Nephew KP. NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer. Oncogene. PMID 27041570 DOI: 10.1038/Onc.2016.75 |
0.377 |
|
| 2016 |
Cooley M, Fang P, Fang F, Nephew K, Chien J. Erratum: Molecular determinants of chemotherapy resistance in ovarian cancer (Pharmacogenomics (2015) 16:16 (1763-1767)) Pharmacogenomics. 17. PMID 26954890 DOI: 10.2217/Pgs.16.13 |
0.367 |
|
| 2016 |
Hahn NM, Cramer HM, Badve SS, Cheng L, Gokmen-Polar Y, Miller DF, Buechlein A, Rusch DB, Fang F, Frankhouser D, Bundschu R, Javkhlan-Ochir G, Koch MO, Bihrle R, Foster R, ... ... Nephew KP, et al. Identification of novel immunomodulatory tumor biology through comprehensive characterization of a metastases-specific epigenome in patients with metachronous primary and metastatic urothelial carcinoma (UC) tumor pairs. Journal of Clinical Oncology. 34: 452-452. DOI: 10.1200/Jco.2016.34.2_Suppl.452 |
0.331 |
|
| 2016 |
Dobbin Z, Cornelison R, Katre AK, Schneider DA, Watters K, Coscia F, Lengyel E, Buechlein A, Fang F, Nephew K, Landen CN. Abstract B39: Identification and targeting mediators of chemoresistance using the patient-derived xenograft model of ovarian cancer Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-B39 |
0.382 |
|
| 2016 |
Fang F, Cardenas H, Miller D, Buechlein A, Yu Q, Liu Y, Jiang G, Taverna P, Keer H, Rusch D, Matei D, Nephew KP. Abstract A70: Epigenome and genome alterations in platinum resistant ovarian tumors. Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Ovca15-A70 |
0.423 |
|
| 2016 |
Wang Y, Mitra AK, Nephew KP. Abstract A57: Platinum induces IL-6-signaling mediated activation of ALDH1A1 and enriches the cancer stem cell population in ovarian cancer. Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Ovca15-A57 |
0.349 |
|
| 2016 |
Wagner E, Wu W, Liu Y, Nephew K, Han J, He C. Abstract A51: DNA methylation in tumor, adjacent non-tumorous and normal breast tissues Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-A51 |
0.395 |
|
| 2016 |
Cheng FH, Aguda BD, Lin H, Tsai J, Kochanczyk M, Lin R, Lin JMJ, Chen GCW, Chang C, Lai H, Nephew KP, Hwang T, Chan MWY. Abstract 950: Bistable switching of c-KIT by estrogen-mediated ceRNA and epigenetic silencing of miR-193a predicts survival in ovarian cancer Cancer Research. 76: 950-950. DOI: 10.1158/1538-7445.Am2016-950 |
0.317 |
|
| 2016 |
Burks HE, Rhodes LV, Martin EC, Hoang VT, Elliott S, Badoo M, Phamduy T, Buechlein A, Rusch D, Chrisey D, Flemington E, Nephew K, Collins-Burow B, Burow ME. Abstract 4410: ZEB2 drives cell motility and metastasis in ER+ breast cancer cells through a novel, E-cadherin independent pathway Cancer Research. 76: 4410-4410. DOI: 10.1158/1538-7445.Am2016-4410 |
0.448 |
|
| 2016 |
Qing Y, Condello S, Meyer KJ, Caperell-Grant A, Nephew KP, Matei D. Abstract 4024: Epigenetic priming potentiates immune checkpoints inhibitors in ovarian cancer Cancer Research. 76: 4024-4024. DOI: 10.1158/1538-7445.Am2016-4024 |
0.392 |
|
| 2016 |
Liang Y, Aebi J, Nephew K, Hyder SM. Abstract 3789: Targeting cholesterol biosynthesis pathway to inhibit growth of drug resistant ovarian cancer cells Cancer Research. 76: 3789-3789. DOI: 10.1158/1538-7445.Am2016-3789 |
0.429 |
|
| 2016 |
Milevskiy MJ, Al-Ejeh F, Saunus JM, Northwood KS, McCart-Reed AE, Dray E, Nephew K, Bailey PJ, Betts JA, Stone A, Gee JMW, Shewan AM, French JD, Edwards SL, Clark SJ, et al. Abstract 1980: Long-range regulation of HOTAIR identifies novel biomarkers of breast cancer outcome and suggests a role in genome instability Cancer Research. 76: 1980-1980. DOI: 10.1158/1538-7445.Am2016-1980 |
0.426 |
|
| 2015 |
Bowtell DD, Böhm S, Ahmed AA, Aspuria PJ, Bast RC, Beral V, Berek JS, Birrer MJ, Blagden S, Bookman MA, Brenton JD, Chiappinelli KB, Martins FC, Coukos G, Drapkin R, ... ... Nephew KP, et al. Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer. Nature Reviews. Cancer. 15: 668-79. PMID 26493647 DOI: 10.1038/Nrc4019 |
0.377 |
|
| 2015 |
Rhodes LV, Tate CR, Hoang VT, Burks HE, Gilliam D, Martin EC, Elliott S, Miller DB, Buechlein A, Rusch D, Tang H, Nephew KP, Burow ME, Collins-Burow BM. Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1. Oncogenesis. 4: e168. PMID 26436950 DOI: 10.1038/oncsis.2015.27 |
0.329 |
|
| 2015 |
Rhodes LV, Martin EC, Segar HC, Miller DF, Buechlein A, Rusch DB, Nephew KP, Burow ME, Collins-Burow BM. Dual regulation by microRNA-200b-3p and microRNA-200b-5p in the inhibition of epithelial-to-mesenchymal transition in triple-negative breast cancer. Oncotarget. 6: 16638-52. PMID 26062653 DOI: 10.18632/Oncotarget.3184 |
0.328 |
|
| 2015 |
Mitra AK, Davis DA, Tomar S, Roy L, Gurler H, Xie J, Lantvit DD, Cardenas H, Fang F, Liu Y, Loughran E, Yang J, Sharon Stack M, Emerson RE, Cowden Dahl KD, ... ... Nephew KP, et al. In vivo tumor growth of high-grade serous ovarian cancer cell lines. Gynecologic Oncology. PMID 26050922 DOI: 10.1016/J.Ygyno.2015.05.040 |
0.397 |
|
| 2015 |
Chou JL, Huang RL, Shay J, Chen LY, Lin SJ, Yan PS, Chao WT, Lai YH, Lai YL, Chao TK, Lee CI, Tai CK, Wu SF, Nephew KP, Huang TH, et al. Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients. Clinical Epigenetics. 7: 1. PMID 25628764 DOI: 10.1186/S13148-014-0036-2 |
0.393 |
|
| 2015 |
Chen Z, Lan X, Thomas-Ahner JM, Wu D, Liu X, Ye Z, Wang L, Sunkel B, Grenade C, Chen J, Zynger DL, Yan PS, Huang J, Nephew KP, Huang TH, et al. Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer. The Embo Journal. 34: 502-16. PMID 25535248 DOI: 10.15252/Embj.201490306 |
0.315 |
|
| 2015 |
Tang J, Fang F, Miller DF, Pilrose JM, Matei D, Huang TH, Nephew KP. Global DNA methylation profiling technologies and the ovarian cancer methylome. Methods in Molecular Biology (Clifton, N.J.). 1238: 653-75. PMID 25421685 DOI: 10.1007/978-1-4939-1804-1_34 |
0.334 |
|
| 2015 |
Matei D, Fang F, Cardenas H, Miller DF, Buechlein A, Yu Q, Perkins SM, Liu Y, Jiang G, Taverna P, Keer HN, Rusch DB, Nephew KP. Epigenome and genome alterations in platinum resistant ovarian cancer. Journal of Clinical Oncology. 33: 5555-5555. DOI: 10.1200/Jco.2015.33.15_Suppl.5555 |
0.39 |
|
| 2015 |
Wang Y, Cardenas H, Fang F, Condello S, Taverna P, Segar M, Liu Y, Matei D, Nephew KP. Abstract POSTER-THER-1421: Epigenetic targeting of ovarian cancer stem cells Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Ovcasymp14-Poster-Ther-1421 |
0.444 |
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| 2015 |
Cardenas H, Vieth E, Lee J, Liu Y, Nephew KP, Matei D. Abstract POSTER-BIOL-1306: DNA methylation changes during epithelial-to-mesenchymal transition in ovarian cancer cells Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Ovcasymp14-Poster-Biol-1306 |
0.425 |
|
| 2015 |
Shajahan-Haq AN, Li L, Liu Y, Jin L, Miller DF, Pilrose J, Cheema AK, Boca SM, Bhuvaneshwar K, Madhavan S, Clarke R, Nephew KP. Abstract B2-09: A systems biology approach to understanding estrogen responsiveness in breast cancer cells using the MCF7 model Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-B2-09 |
0.441 |
|
| 2015 |
Pulliam N, Taverna P, Lyons J, Nephew KP. Abstract 2943: Novel combination therapy of DNMT inhibitor SGI-110 and PARP inhibitor BMN-673 (talazoparib) for BRCA-proficient ovarian cancer Cancer Research. 75: 2943-2943. DOI: 10.1158/1538-7445.Am2015-2943 |
0.432 |
|
| 2014 |
Cheng FH, Aguda BD, Tsai JC, Kocha?czyk M, Lin JM, Chen GC, Lai HC, Nephew KP, Hwang TW, Chan MW. A mathematical model of bimodal epigenetic control of miR-193a in ovarian cancer stem cells. Plos One. 9: e116050. PMID 25545504 DOI: 10.1371/Journal.Pone.0116050 |
0.354 |
|
| 2014 |
Cardenas H, Vieth E, Lee J, Segar M, Liu Y, Nephew KP, Matei D. TGF-β induces global changes in DNA methylation during the epithelial-to-mesenchymal transition in ovarian cancer cells. Epigenetics : Official Journal of the Dna Methylation Society. 9: 1461-72. PMID 25470663 DOI: 10.4161/15592294.2014.971608 |
0.362 |
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| 2014 |
Mourad R, Hsu PY, Juan L, Shen C, Koneru P, Lin H, Liu Y, Nephew K, Huang TH, Li L. Estrogen induces global reorganization of chromatin structure in human breast cancer cells. Plos One. 9: e113354. PMID 25470140 DOI: 10.1371/Journal.Pone.0113354 |
0.387 |
|
| 2014 |
Zhang Y, Zhao FJ, Chen LL, Wang LQ, Nephew KP, Wu YL, Zhang S. MiR-373 targeting of the Rab22a oncogene suppresses tumor invasion and metastasis in ovarian cancer. Oncotarget. 5: 12291-303. PMID 25460499 DOI: 10.18632/Oncotarget.2577 |
0.321 |
|
| 2014 |
Zhuang Y, Nguyen HT, Burow ME, Zhuo Y, El-Dahr SS, Yao X, Cao S, Flemington EK, Nephew KP, Fang F, Collins-Burow B, Rhodes LV, Yu Q, Jayawickramarajah J, Shan B. Elevated expression of long intergenic non-coding RNA HOTAIR in a basal-like variant of MCF-7 breast cancer cells. Molecular Carcinogenesis. PMID 25328122 DOI: 10.1002/Mc.22237 |
0.438 |
|
| 2014 |
Fang F, Munck J, Tang J, Taverna P, Wang Y, Miller DF, Pilrose J, Choy G, Azab M, Pawelczak KS, VanderVere-Carozza P, Wagner M, Lyons J, Matei D, Turchi JJ, ... Nephew KP, et al. The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 6504-16. PMID 25316809 DOI: 10.1158/1078-0432.Ccr-14-1553 |
0.426 |
|
| 2014 |
Martin EC, Rhodes LV, Elliott S, Krebs AE, Nephew KP, Flemington EK, Collins-Burow BM, Burow ME. microRNA regulation of mammalian target of rapamycin expression and activity controls estrogen receptor function and RAD001 sensitivity. Molecular Cancer. 13: 229. PMID 25283550 DOI: 10.1186/1476-4598-13-229 |
0.376 |
|
| 2014 |
Wang Y, Cardenas H, Fang F, Condello S, Taverna P, Segar M, Liu Y, Nephew KP, Matei D. Epigenetic targeting of ovarian cancer stem cells. Cancer Research. 74: 4922-36. PMID 25035395 DOI: 10.1158/0008-5472.Can-14-1022 |
0.44 |
|
| 2014 |
Fang F, Zuo Q, Pilrose J, Wang Y, Shen C, Li M, Wulfridge P, Matei D, Nephew KP. Decitabine reactivated pathways in platinum resistant ovarian cancer. Oncotarget. 5: 3579-89. PMID 25003579 DOI: 10.18632/Oncotarget.1961 |
0.407 |
|
| 2014 |
Liao YP, Chen LY, Huang RL, Su PH, Chan MW, Chang CC, Yu MH, Wang PH, Yen MS, Nephew KP, Lai HC. Hypomethylation signature of tumor-initiating cells predicts poor prognosis of ovarian cancer patients. Human Molecular Genetics. 23: 1894-906. PMID 24256813 DOI: 10.1093/Hmg/Ddt583 |
0.396 |
|
| 2014 |
Lengyel E, Burdette JE, Kenny HA, Matei D, Pilrose J, Haluska P, Nephew KP, Hales DB, Stack MS. Epithelial ovarian cancer experimental models. Oncogene. 33: 3619-33. PMID 23934194 DOI: 10.1038/Onc.2013.321 |
0.357 |
|
| 2014 |
Huang Z, Li H, Huang Q, Chen D, Han J, Wang L, Pan C, Chen W, House MG, Nephew KP, Guo Z. SERPINB2 down-regulation contributes to chemoresistance in head and neck cancer. Molecular Carcinogenesis. 53: 777-86. PMID 23661500 DOI: 10.1002/Mc.22033 |
0.399 |
|
| 2014 |
Ozes AR, Miller DF, Liu Y, Nephew KP. Abstract 3551: Non-coding RNA HOTAIR connects DNA damage signaling to NF-κB activation in cisplatin resistant ovarian cancer Cancer Research. 74: 3551-3551. DOI: 10.1158/1538-7445.Am2014-3551 |
0.394 |
|
| 2014 |
Fleming G, Ghamande S, Lin Y, Secord AA, Nemunaitis J, Markham M, Nephew K, Fang F, Gupta S, Naim S, Choy G, Jueliger S, Taverna P, Hao Y, Keer H, et al. Abstract 2320: Clinical epigenetic resensitization of platinum-resistant, recurrent ovarian cancer patients with SGI-110, a novel, second-generation, subcutaneously administered hypomethylating agent (HMA) Cancer Research. 74: 2320-2320. DOI: 10.1158/1538-7445.Am2014-2320 |
0.391 |
|
| 2014 |
Wang Y, Cardenas H, Fang F, Condello S, Taverna P, Choy G, Azab M, Nephew K, Matei D. Abstract 2317: SGI-110 alters ovarian cancer stem cells to prevent recurrent and chemoresistant ovarian cancer Cancer Research. 74: 2317-2317. DOI: 10.1158/1538-7445.Am2014-2317 |
0.455 |
|
| 2014 |
Rhodes LV, Tate CR, Burks HE, Hoang VT, Gilliam D, Martin EC, Elliott S, Miller DF, Buechlein A, Rusch D, Tang H, Nephew KP, Burow ME, Collins-Burow BM. Abstract 1571: The tumor suppressor Liver Kinase B1 inhibits triple-negative breast cancer cell metastasis via regulation of AP-1 signaling Cancer Research. 74: 1571-1571. DOI: 10.1158/1538-7445.Am2014-1571 |
0.439 |
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| 2014 |
Burks HE, Rhodes L, Martin E, Phamduy T, Elliot S, Hoang V, Segar H, Buechlein A, Rusch D, Miller D, Baddoo M, Flemington E, Nephew K, Chrisey D, Collins-Burow B, et al. Abstract 1034: ZEB2 promotes cell motility and metastasis in ER+ breast cancer cells Cancer Research. 74: 1034-1034. DOI: 10.1158/1538-7445.Am2014-1034 |
0.431 |
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| 2013 |
Antoon JW, Martin EC, Lai R, Salvo VA, Tang Y, Nitzchke AM, Elliott S, Nam SY, Xiong W, Rhodes LV, Collins-Burow B, David O, Wang G, Shan B, Beckman BS, ... Nephew KP, et al. MEK5/ERK5 signaling suppresses estrogen receptor expression and promotes hormone-independent tumorigenesis. Plos One. 8: e69291. PMID 23950888 DOI: 10.1371/Journal.Pone.0069291 |
0.447 |
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| 2013 |
Hsu PY, Hsu HK, Lan X, Juan L, Yan PS, Labanowska J, Heerema N, Hsiao TH, Chiu YC, Chen Y, Liu Y, Li L, Li R, Thompson IM, Nephew KP, et al. Amplification of distant estrogen response elements deregulates target genes associated with tamoxifen resistance in breast cancer. Cancer Cell. 24: 197-212. PMID 23948299 DOI: 10.1016/J.Ccr.2013.07.007 |
0.41 |
|
| 2013 |
Zhang L, Cui J, Leonard M, Nephew K, Li Y, Zhang X. Silencing MED1 sensitizes breast cancer cells to pure anti-estrogen fulvestrant in vitro and in vivo. Plos One. 8: e70641. PMID 23936234 DOI: 10.1371/Journal.Pone.0070641 |
0.458 |
|
| 2013 |
Rhee JK, Kim K, Chae H, Evans J, Yan P, Zhang BT, Gray J, Spellman P, Huang TH, Nephew KP, Kim S. Integrated analysis of genome-wide DNA methylation and gene expression profiles in molecular subtypes of breast cancer. Nucleic Acids Research. 41: 8464-74. PMID 23887935 DOI: 10.1093/Nar/Gkt643 |
0.426 |
|
| 2013 |
Ozes AR, Nephew KP. 3D culture adds an extra dimension to targeted epigenetic therapies. Cell Cycle (Georgetown, Tex.). 12: 2173-4. PMID 23803725 DOI: 10.4161/Cc.25551 |
0.442 |
|
| 2013 |
An J, Kim K, Rhee SM, Chae H, Nephew KP, Kim S. Genome-wide analysis and modeling of DNA methylation susceptibility in 30 breast cancer cell lines by using CpG flanking sequences. Journal of Bioinformatics and Computational Biology. 11: 1341003. PMID 23796180 DOI: 10.1142/S0219720013410035 |
0.331 |
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| 2013 |
Huang RL, Gu F, Kirma NB, Ruan J, Chen CL, Wang HC, Liao YP, Chang CC, Yu MH, Pilrose JM, Thompson IM, Huang HC, Huang TH, Lai HC, Nephew KP. Comprehensive methylome analysis of ovarian tumors reveals hedgehog signaling pathway regulators as prognostic DNA methylation biomarkers. Epigenetics : Official Journal of the Dna Methylation Society. 8: 624-34. PMID 23774800 DOI: 10.4161/Epi.24816 |
0.395 |
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| 2013 |
Di Leva G, Piovan C, Gasparini P, Ngankeu A, Taccioli C, Briskin D, Cheung DG, Bolon B, Anderlucci L, Alder H, Nuovo G, Li M, Iorio MV, Galasso M, Santhanam R, ... ... Nephew KP, et al. Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. Plos Genetics. 9: e1003311. PMID 23505378 DOI: 10.1371/Journal.Pgen.1003311 |
0.328 |
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| 2013 |
Antoon JW, Nitzchke AM, Martin EC, Rhodes LV, Nam S, Wadsworth S, Salvo VA, Elliott S, Collins-Burow B, Nephew KP, Burow ME. Inhibition of p38 mitogen-activated protein kinase alters microRNA expression and reverses epithelial-to-mesenchymal transition. International Journal of Oncology. 42: 1139-50. PMID 23403951 DOI: 10.3892/Ijo.2013.1814 |
0.423 |
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| 2013 |
Rao X, Evans J, Chae H, Pilrose J, Kim S, Yan P, Huang RL, Lai HC, Lin H, Liu Y, Miller D, Rhee JK, Huang YW, Gu F, Gray JW, ... ... Nephew KP, et al. CpG island shore methylation regulates caveolin-1 expression in breast cancer. Oncogene. 32: 4519-28. PMID 23128390 DOI: 10.1038/Onc.2012.474 |
0.582 |
|
| 2013 |
Balch C, Nephew KP. Epigenetic targeting therapies to overcome chemotherapy resistance. Advances in Experimental Medicine and Biology. 754: 285-311. PMID 22956507 DOI: 10.1007/978-1-4419-9967-2_14 |
0.389 |
|
| 2013 |
Ozes AR, Miller D, Guo C, Bhattrai A, Liu Y, Nephew KP. Abstract 5189: The transcriptional regulation of the long non-coding RNA HOTAIR in ovarian cancer. Cancer Research. 73: 5189-5189. DOI: 10.1158/1538-7445.Am2013-5189 |
0.415 |
|
| 2013 |
Tang J, Fang F, Wang Y, Taverna P, Miller DFB, Choy G, Azab M, Matei D, Pawelczak KS, VanderVere-Carozza P, Wagner M, Turchi JJ, Nephew KP. Abstract 4623: The novel, small molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer. Cancer Research. 73: 4623-4623. DOI: 10.1158/1538-7445.Am2013-4623 |
0.447 |
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| 2013 |
Cardenas H, Goswami C, Nephew KP, Matei D. Abstract 2978: DNA methylation changes during epithelial-to-mesenchymal transition in ovarian cancer cells. Cancer Research. 73: 2978-2978. DOI: 10.1158/1538-7445.Am2013-2978 |
0.421 |
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| 2013 |
Nephew KP, Matei D, Taverna P, Fang F, Tang J, Choy G, Lyons J, Azab M, Pilrose J, Turchi J. Abstract IA17: Targeting the methylome for epigenetic resensitization of ovarian cancer Clinical Cancer Research. 19. DOI: 10.1158/1078-0432.Ovca13-Ia17 |
0.45 |
|
| 2012 |
Zhang P, Mourad R, Xiang Y, Huang K, Huang T, Nephew K, Liu Y, Li L. A dynamic time order network for time-series gene expression data analysis. Bmc Systems Biology. 6: S9. PMID 23281615 DOI: 10.1186/1752-0509-6-S3-S9 |
0.315 |
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| 2012 |
Nam S, Long X, Kwon C, Kim S, Nephew KP. An integrative analysis of cellular contexts, miRNAs and mRNAs reveals network clusters associated with antiestrogen-resistant breast cancer cells. Bmc Genomics. 13: 732. PMID 23270413 DOI: 10.1186/1471-2164-13-732 |
0.582 |
|
| 2012 |
Wu HY, Zheng P, Jiang G, Liu Y, Nephew KP, Huang TH, Li L. A modulator based regulatory network for ERα signaling pathway. Bmc Genomics. 13: S6. PMID 23134758 DOI: 10.1186/1471-2164-13-S6-S6 |
0.307 |
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| 2012 |
Teng M, Wang Y, Kim S, Li L, Shen C, Wang G, Liu Y, Huang TH, Nephew KP, Balch C. Empirical bayes model comparisons for differential methylation analysis. Comparative and Functional Genomics. 2012: 376706. PMID 22956892 DOI: 10.1155/2012/376706 |
0.303 |
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| 2012 |
Antoon JW, Lai R, Struckhoff AP, Nitschke AM, Elliott S, Martin EC, Rhodes LV, Yoon NS, Salvo VA, Shan B, Beckman BS, Nephew KP, Burow ME. Altered death receptor signaling promotes epithelial-to-mesenchymal transition and acquired chemoresistance. Scientific Reports. 2: 539. PMID 22844580 DOI: 10.1038/Srep00539 |
0.396 |
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| 2012 |
Bratton MR, Frigo DE, Segar HC, Nephew KP, McLachlan JA, Wiese TE, Burow ME. The organochlorine o,p'-DDT plays a role in coactivator-mediated MAPK crosstalk in MCF-7 breast cancer cells. Environmental Health Perspectives. 120: 1291-6. PMID 22609851 DOI: 10.1289/Ehp.1104296 |
0.376 |
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| 2012 |
Yo YT, Lin YW, Wang YC, Balch C, Huang RL, Chan MW, Sytwu HK, Chen CK, Chang CC, Nephew KP, Huang T, Yu MH, Lai HC. Growth inhibition of ovarian tumor-initiating cells by niclosamide. Molecular Cancer Therapeutics. 11: 1703-12. PMID 22576131 DOI: 10.1158/1535-7163.Mct-12-0002 |
0.409 |
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| 2012 |
Matei D, Fang F, Shen C, Schilder J, Arnold A, Zeng Y, Berry WA, Huang T, Nephew KP. Epigenetic resensitization to platinum in ovarian cancer. Cancer Research. 72: 2197-205. PMID 22549947 DOI: 10.1158/0008-5472.Can-11-3909 |
0.448 |
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| 2012 |
Balch C, Naegeli K, Nam S, Ballard B, Hyslop A, Melki C, Reilly E, Hur MW, Nephew KP. A unique histone deacetylase inhibitor alters microRNA expression and signal transduction in chemoresistant ovarian cancer cells. Cancer Biology & Therapy. 13: 681-93. PMID 22549158 DOI: 10.4161/Cbt.20086 |
0.442 |
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| 2012 |
Yang Y, Nephew K, Kim S. A novel k-mer mixture logistic regression for methylation susceptibility modeling of CpG dinucleotides in human gene promoters. Bmc Bioinformatics. S15. PMID 22536899 DOI: 10.1186/1471-2105-13-S3-S15 |
0.361 |
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| 2012 |
Teng M, Balch C, Liu Y, Li M, Huang TH, Wang Y, Nephew KP, Li L. The influence of cis-regulatory elements on DNA methylation fidelity. Plos One. 7: e32928. PMID 22412954 DOI: 10.1371/Journal.Pone.0032928 |
0.36 |
|
| 2012 |
Tilghman SL, Bratton MR, Segar HC, Martin EC, Rhodes LV, Li M, McLachlan JA, Wiese TE, Nephew KP, Burow ME. Endocrine disruptor regulation of microRNA expression in breast carcinoma cells. Plos One. 7: e32754. PMID 22403704 DOI: 10.1371/Journal.Pone.0032754 |
0.385 |
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| 2012 |
Jeon BN, Kim MK, Choi WI, Koh DI, Hong SY, Kim KS, Kim M, Yun CO, Yoon J, Choi KY, Lee KR, Nephew KP, Hur MW. KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A. Cancer Research. 72: 1137-48. PMID 22253232 DOI: 10.1158/0008-5472.Can-11-2433 |
0.372 |
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| 2012 |
Chen B, Chen J, House MG, Cullen KJ, Nephew KP, Guo Z. Role of neurofilament light polypeptide in head and neck cancer chemoresistance. Molecular Cancer Research : McR. 10: 305-15. PMID 22246235 DOI: 10.1158/1541-7786.Mcr-11-0300 |
0.402 |
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| 2012 |
Rhodes LV, Nitschke AM, Segar HC, Martin EC, Driver JL, Elliott S, Nam SY, Li M, Nephew KP, Burow ME, Collins-Burow BM. The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells. Oncology Reports. 27: 10-6. PMID 21971930 DOI: 10.3892/Or.2011.1488 |
0.397 |
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| 2012 |
Balch C, Jadhav R, Fang F, Pilrose J, Li M, Shen C, Li L, Huang TH, Nephew KP. Abstract 5206: Systems biology identification of processes/pathways facilitating the development of high-grade serous ovarian cancer Cancer Research. 72: 5206-5206. DOI: 10.1158/1538-7445.Am2012-5206 |
0.45 |
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| 2012 |
Rao X, Evans J, Chae H, Kim S, Liu Y, Huang T, Nephew K. Abstract 5013: CpG island shore methylation regulates caveolin-1 expression in breast cancer Cancer Research. 72: 5013-5013. DOI: 10.1158/1538-7445.Am2012-5013 |
0.63 |
|
| 2012 |
Miller DF, Lui Y, Yan P, Rodriguez B, Lin H, Goel S, Jani E, Bhattrai A, Koekesh K, Guo C, Huang TH, Nephew KP. Abstract 4188: Whole transcriptome analyses of platinum-resistant ovarian cancer cells Cancer Research. 72: 4188-4188. DOI: 10.1158/1538-7445.Am2012-4188 |
0.461 |
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| 2012 |
Huang Q, Golas AA, Guo Z, Nephew KP, House MG. Mo1882 DNA Methylation as a Biomarker System for Pancreatic Adenocarcinoma Gastroenterology. 142: S-1087. DOI: 10.1016/S0016-5085(12)64224-3 |
0.362 |
|
| 2011 |
Matei D, Shen C, Fang F, Schilder J, Li M, Arnold A, Zeng Y, Pilrose JM, Kulesavage C, Balch C, Berry W, Wulfridge P, Huang TH, Nephew KP. A phase II study of decitabine and carboplatin in recurrent platinum (Pt)-resistant ovarian cancer (OC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 5011. PMID 28023753 DOI: 10.1200/Jco.2011.29.15_Suppl.5011 |
0.353 |
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| 2011 |
Vaughan S, Coward JI, Bast RC, Berchuck A, Berek JS, Brenton JD, Coukos G, Crum CC, Drapkin R, Etemadmoghadam D, Friedlander M, Gabra H, Kaye SB, Lord CJ, Lengyel E, ... ... Nephew KP, et al. Rethinking ovarian cancer: recommendations for improving outcomes. Nature Reviews. Cancer. 11: 719-25. PMID 21941283 DOI: 10.1038/Nrc3144 |
0.351 |
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| 2011 |
Rhodes LV, Bratton MR, Zhu Y, Tilghman SL, Muir SE, Salvo VA, Tate CR, Elliott S, Nephew KP, Collins-Burow BM, Burow ME. Effects of SDF-1-CXCR4 signaling on microRNA expression and tumorigenesis in estrogen receptor-alpha (ER-α)-positive breast cancer cells. Experimental Cell Research. 317: 2573-81. PMID 21906588 DOI: 10.1016/J.Yexcr.2011.08.016 |
0.441 |
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| 2011 |
Zhang C, Wang L, Wu D, Chen H, Chen Z, Thomas-Ahner JM, Zynger DL, Eeckhoute J, Yu J, Luo J, Brown M, Clinton SK, Nephew KP, Huang TH, Li W, et al. Definition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer. Cancer Research. 71: 6738-48. PMID 21900400 DOI: 10.1158/0008-5472.Can-11-1882 |
0.361 |
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| 2011 |
Wu D, Zhang C, Shen Y, Nephew KP, Wang Q. Androgen receptor-driven chromatin looping in prostate cancer. Trends in Endocrinology and Metabolism: Tem. 22: 474-80. PMID 21889355 DOI: 10.1016/J.Tem.2011.07.006 |
0.315 |
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| 2011 |
Bareford MD, Hamed HA, Tang Y, Cruickshanks N, Burow ME, Fisher PB, Moran RG, Nephew KP, Grant S, Dent P. Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells. Autophagy. 7: 1261-2. PMID 21814046 DOI: 10.4161/Auto.7.10.17029 |
0.359 |
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| 2011 |
Kennedy BA, Deatherage DE, Gu F, Tang B, Chan MW, Nephew KP, Huang TH, Jin VX. ChIP-seq defined genome-wide map of TGFβ/SMAD4 targets: implications with clinical outcome of ovarian cancer. Plos One. 6: e22606. PMID 21799915 DOI: 10.1371/Journal.Pone.0022606 |
0.428 |
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| 2011 |
Chen B, Rao X, House MG, Nephew KP, Cullen KJ, Guo Z. GPx3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response. Cancer Letters. 309: 37-45. PMID 21684681 DOI: 10.1016/J.Canlet.2011.05.013 |
0.575 |
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| 2011 |
Bareford MD, Park MA, Yacoub A, Hamed HA, Tang Y, Cruickshanks N, Eulitt P, Hubbard N, Tye G, Burow ME, Fisher PB, Moran RG, Nephew KP, Grant S, Dent P. Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells. Cancer Research. 71: 4955-67. PMID 21622715 DOI: 10.1158/0008-5472.Can-11-0898 |
0.369 |
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| 2011 |
Shen C, Huang Y, Liu Y, Wang G, Zhao Y, Wang Z, Teng M, Wang Y, Flockhart DA, Skaar TC, Yan P, Nephew KP, Huang TH, Li L. A modulated empirical Bayes model for identifying topological and temporal estrogen receptor α regulatory networks in breast cancer. Bmc Systems Biology. 5: 67. PMID 21554733 DOI: 10.1186/1752-0509-5-67 |
0.418 |
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| 2011 |
Yeh KT, Chen TH, Yang HW, Chou JL, Chen LY, Yeh CM, Chen YH, Lin RI, Su HY, Chen GC, Deatherage DE, Huang YW, Yan PS, Lin HJ, Nephew KP, et al. Aberrant TGFβ/SMAD4 signaling contributes to epigenetic silencing of a putative tumor suppressor, RunX1T1 in ovarian cancer. Epigenetics : Official Journal of the Dna Methylation Society. 6: 727-39. PMID 21540640 DOI: 10.4161/Epi.6.6.15856 |
0.469 |
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| 2011 |
Teng IW, Hou PC, Lee KD, Chu PY, Yeh KT, Jin VX, Tseng MJ, Tsai SJ, Chang YS, Wu CS, Sun HS, Tsai KD, Jeng LB, Nephew KP, Huang TH, et al. Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells. Cancer Research. 71: 4653-63. PMID 21518779 DOI: 10.1158/0008-5472.Can-10-3418 |
0.356 |
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| 2011 |
Zhou FC, Balaraman Y, Teng M, Liu Y, Singh RP, Nephew KP. Alcohol alters DNA methylation patterns and inhibits neural stem cell differentiation. Alcoholism, Clinical and Experimental Research. 35: 735-46. PMID 21223309 DOI: 10.1111/J.1530-0277.2010.01391.X |
0.306 |
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| 2011 |
Rhodes LV, Short SP, Neel NF, Salvo VA, Zhu Y, Elliott S, Wei Y, Yu D, Sun M, Muir SE, Fonseca JP, Bratton MR, Segar C, Tilghman SL, Sobolik-Delmaire T, ... ... Nephew KP, et al. Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer. Cancer Research. 71: 603-13. PMID 21123450 DOI: 10.1158/0008-5472.Can-10-3185 |
0.424 |
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| 2011 |
Rao X, Di Leva G, Li M, Fang F, Devlin C, Hartman-Frey C, Burow ME, Ivan M, Croce CM, Nephew KP. MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways. Oncogene. 30: 1082-97. PMID 21057537 DOI: 10.1038/Onc.2010.487 |
0.571 |
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| 2011 |
Rao X, Evans J, Chae H, Rhee J, Kim S, Huang TH, Nephew KP. Abstract C22: Next-generation sequencing reveals CpG island shore methylation regulates caveolin-1 expression in breast cancer Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-C22 |
0.642 |
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| 2011 |
Chou J, Chen L, Su H, Lin S, Huang Y, Deatherage DE, Yan PS, Nephew KP, Lee C, Huang TH-, Lai H, Chan MWY. Abstract 83: Hypomethylation of TGF-beta target gene,ABCA1in ovarian cancer and cancer initialing cell and is associated with poor prognosis in cancer patients Cancer Research. 71: 83-83. DOI: 10.1158/1538-7445.Am2011-83 |
0.474 |
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| 2010 |
Balch C, Matei DE, Huang TH, Nephew KP. Role of epigenomics in ovarian and endometrial cancers. Epigenomics. 2: 419-47. PMID 22121902 DOI: 10.2217/Epi.10.19 |
0.453 |
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| 2010 |
Balch C, Nephew KP. The role of chromatin, microRNAs, and tumor stem cells in ovarian cancer. Cancer Biomarkers : Section a of Disease Markers. 8: 203-21. PMID 22045354 DOI: 10.3233/Cbm-2011-0214 |
0.466 |
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| 2010 |
Jeong J, Li L, Liu Y, Nephew KP, Huang TH, Shen C. An empirical Bayes model for gene expression and methylation profiles in antiestrogen resistant breast cancer. Bmc Medical Genomics. 3: 55. PMID 21108837 DOI: 10.1186/1755-8794-3-55 |
0.445 |
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| 2010 |
Wang G, Wang Y, Shen C, Huang YW, Huang K, Huang TH, Nephew KP, Li L, Liu Y. RNA polymerase II binding patterns reveal genomic regions involved in microRNA gene regulation. Plos One. 5: e13798. PMID 21072189 DOI: 10.1371/Journal.Pone.0013798 |
0.348 |
|
| 2010 |
Mitchell C, Yacoub A, Hossein H, Martin AP, Bareford MD, Eulitt P, Yang C, Nephew KP, Dent P. Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo. Cancer Biology & Therapy. 10: 903-17. PMID 20855960 DOI: 10.4161/Cbt.10.9.13273 |
0.408 |
|
| 2010 |
Foley J, Nickerson NK, Nam S, Allen KT, Gilmore JL, Nephew KP, Riese DJ. EGFR signaling in breast cancer: bad to the bone. Seminars in Cell & Developmental Biology. 21: 951-60. PMID 20813200 DOI: 10.1016/J.Semcdb.2010.08.009 |
0.311 |
|
| 2010 |
Bapat SA, Jin V, Berry N, Balch C, Sharma N, Kurrey N, Zhang S, Fang F, Lan X, Li M, Kennedy B, Bigsby RM, Huang TH, Nephew KP. Multivalent epigenetic marks confer microenvironment-responsive epigenetic plasticity to ovarian cancer cells. Epigenetics. 5: 716-29. PMID 20676026 DOI: 10.4161/Epi.5.8.13014 |
0.447 |
|
| 2010 |
Fang F, Balch C, Schilder J, Breen T, Zhang S, Shen C, Li L, Kulesavage C, Snyder AJ, Nephew KP, Matei DE. A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer. Cancer. 116: 4043-53. PMID 20564122 DOI: 10.1002/Cncr.25204 |
0.413 |
|
| 2010 |
Hsu PY, Hsu HK, Singer GA, Yan PS, Rodriguez BA, Liu JC, Weng YI, Deatherage DE, Chen Z, Pereira JS, Lopez R, Russo J, Wang Q, Lamartiniere CA, Nephew KP, et al. Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping. Genome Research. 20: 733-44. PMID 20442245 DOI: 10.1101/Gr.101923.109 |
0.431 |
|
| 2010 |
Rickert EL, Oriana S, Hartman-Frey C, Long X, Webb TT, Nephew KP, Weatherman RV. Synthesis and characterization of fluorescent 4-hydroxytamoxifen conjugates with unique antiestrogenic properties. Bioconjugate Chemistry. 21: 903-10. PMID 20420372 DOI: 10.1021/Bc900461H |
0.585 |
|
| 2010 |
Di Leva G, Gasparini P, Piovan C, Ngankeu A, Garofalo M, Taccioli C, Iorio MV, Li M, Volinia S, Alder H, Nakamura T, Nuovo G, Liu Y, Nephew KP, Croce CM. MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer. Journal of the National Cancer Institute. 102: 706-21. PMID 20388878 DOI: 10.1093/Jnci/Djq102 |
0.371 |
|
| 2010 |
McCune K, Bhat-Nakshatri P, Thorat MA, Nephew KP, Badve S, Nakshatri H. Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet. Cancer Research. 70: 685-96. PMID 20068169 DOI: 10.1158/0008-5472.Can-09-1530 |
0.402 |
|
| 2010 |
Chou JL, Su HY, Chen LY, Liao YP, Hartman-Frey C, Lai YH, Yang HW, Deatherage DE, Kuo CT, Huang YW, Yan PS, Hsiao SH, Tai CK, Lin HJ, Davuluri RV, ... ... Nephew KP, et al. Promoter hypermethylation of FBXO32, a novel TGF-beta/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer. Laboratory Investigation; a Journal of Technical Methods and Pathology. 90: 414-25. PMID 20065949 DOI: 10.1038/Labinvest.2009.138 |
0.465 |
|
| 2010 |
Long X, Fan M, Nephew KP. Estrogen receptor-alpha-interacting cytokeratins potentiate the antiestrogenic activity of fulvestrant. Cancer Biology & Therapy. 9: 389-96. PMID 20061804 DOI: 10.4161/Cbt.9.5.10926 |
0.624 |
|
| 2010 |
Kwon MJ, Kim SS, Choi YL, Jung HS, Balch C, Kim SH, Song YS, Marquez VE, Nephew KP, Shin YK. Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications. Carcinogenesis. 31: 974-83. PMID 20053926 DOI: 10.1093/Carcin/Bgp336 |
0.392 |
|
| 2010 |
Matei DE, Nephew KP. Epigenetic therapies for chemoresensitization of epithelial ovarian cancer. Gynecologic Oncology. 116: 195-201. PMID 19854495 DOI: 10.1016/J.Ygyno.2009.09.043 |
0.398 |
|
| 2010 |
Chou J, Su H, Chen L, Liao Y, Hartman-Frey C, Lai Y, Yang H, Deatherage DE, Kuo C, Huang Y, Yan PS, Hsiao S, Tai C, Lin HL, Davuluri RV, ... ... Nephew KP, et al. Abstract 3072: Promoter hypermethylation of FBXO32, a novel TGF-β/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer Cancer Research. 70: 3072-3072. DOI: 10.1158/1538-7445.Am10-3072 |
0.441 |
|
| 2009 |
Liu Y, Balaraman Y, Wang G, Nephew KP, Zhou FC. Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation. Epigenetics. 4: 500-11. PMID 20009564 DOI: 10.4161/Epi.4.7.9925 |
0.335 |
|
| 2009 |
Martin AP, Mitchell C, Rahmani M, Nephew KP, Grant S, Dent P. Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy. Cancer Biology & Therapy. 8: 2084-96. PMID 19823038 DOI: 10.4161/Cbt.8.21.9895 |
0.36 |
|
| 2009 |
Nephew KP, Balch C, Zhang S, Huang TH. Epigenetics and ovarian cancer. Cancer Treatment and Research. 149: 131-46. PMID 19763434 DOI: 10.1007/978-0-387-98094-2_6 |
0.379 |
|
| 2009 |
Huang YW, Jansen RA, Fabbri E, Potter D, Liyanarachchi S, Chan MW, Liu JC, Crijns AP, Brown R, Nephew KP, van der Zee AG, Cohn DE, Yan PS, Huang TH, Lin HJ. Identification of candidate epigenetic biomarkers for ovarian cancer detection. Oncology Reports. 22: 853-61. PMID 19724865 DOI: 10.3892/Or_00000509 |
0.412 |
|
| 2009 |
Balch C, Fang F, Matei DE, Huang TH, Nephew KP. Minireview: epigenetic changes in ovarian cancer. Endocrinology. 150: 4003-11. PMID 19574400 DOI: 10.1210/En.2009-0404 |
0.406 |
|
| 2009 |
Li M, Balch C, Montgomery JS, Jeong M, Chung JH, Yan P, Huang TH, Kim S, Nephew KP. Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer. Bmc Medical Genomics. 2: 34. PMID 19505326 DOI: 10.1186/1755-8794-2-34 |
0.449 |
|
| 2009 |
Yang YT, Balch C, Kulp SK, Mand MR, Nephew KP, Chen CS. A rationally designed histone deacetylase inhibitor with distinct antitumor activity against ovarian cancer. Neoplasia (New York, N.Y.). 11: 552-63, 3 p followin. PMID 19484144 DOI: 10.1593/Neo.09204 |
0.445 |
|
| 2009 |
Xin F, Li M, Balch C, Thomson M, Fan M, Liu Y, Hammond SM, Kim S, Nephew KP. Computational analysis of microRNA profiles and their target genes suggests significant involvement in breast cancer antiestrogen resistance. Bioinformatics (Oxford, England). 25: 430-4. PMID 19091772 DOI: 10.1093/Bioinformatics/Btn646 |
0.389 |
|
| 2009 |
Nephew KP, Balch C, Skalnik DG. Methyl group acceptance assay for the determination of global DNA methylation levels. Methods in Molecular Biology (Clifton, N.J.). 507: 35-41. PMID 18987804 DOI: 10.1007/978-1-59745-522-0_3 |
0.308 |
|
| 2008 |
Zhou C, Nitschke AM, Xiong W, Zhang Q, Tang Y, Bloch M, Elliott S, Zhu Y, Bazzone L, Yu D, Weldon CB, Schiff R, McLachlan JA, Beckman BS, Wiese TE, ... Nephew KP, et al. Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype. Breast Cancer Research : Bcr. 10: R105. PMID 19087274 DOI: 10.1186/Bcr2210 |
0.393 |
|
| 2008 |
Feng W, Liu Y, Wu J, Nephew KP, Huang TH, Li L. A Poisson mixture model to identify changes in RNA polymerase II binding quantity using high-throughput sequencing technology. Bmc Genomics. 9: S23. PMID 18831789 DOI: 10.1186/1471-2164-9-S2-S23 |
0.333 |
|
| 2008 |
Chan MW, Huang YW, Hartman-Frey C, Kuo CT, Deatherage D, Qin H, Cheng AS, Yan PS, Davuluri RV, Huang TH, Nephew KP, Lin HJ. Aberrant transforming growth factor beta1 signaling and SMAD4 nuclear translocation confer epigenetic repression of ADAM19 in ovarian cancer. Neoplasia (New York, N.Y.). 10: 908-19. PMID 18714391 DOI: 10.1593/Neo.08540 |
0.352 |
|
| 2008 |
Long X, Fan M, Bigsby RM, Nephew KP. Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-alpha-dependent and estrogen receptor-alpha-independent mechanisms. Molecular Cancer Therapeutics. 7: 2096-108. PMID 18645020 DOI: 10.1158/1535-7163.Mct-07-2350 |
0.626 |
|
| 2008 |
Zhang S, Balch C, Chan MW, Lai HC, Matei D, Schilder JM, Yan PS, Huang TH, Nephew KP. Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Research. 68: 4311-20. PMID 18519691 DOI: 10.1158/0008-5472.Can-08-0364 |
0.354 |
|
| 2008 |
Tan B, Long X, Nakshatri H, Nephew KP, Bigsby RM. Striatin-3 gamma inhibits estrogen receptor activity by recruiting a protein phosphatase. Journal of Molecular Endocrinology. 40: 199-210. PMID 18434427 DOI: 10.1677/Jme-07-0132 |
0.549 |
|
| 2008 |
Berry NB, Fan M, Nephew KP. Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome. Molecular Endocrinology (Baltimore, Md.). 22: 1535-51. PMID 18388150 DOI: 10.1210/Me.2007-0449 |
0.373 |
|
| 2008 |
Cheng AS, Culhane AC, Chan MW, Venkataramu CR, Ehrich M, Nasir A, Rodriguez BA, Liu J, Yan PS, Quackenbush J, Nephew KP, Yeatman TJ, Huang TH. Epithelial progeny of estrogen-exposed breast progenitor cells display a cancer-like methylome. Cancer Research. 68: 1786-96. PMID 18339859 DOI: 10.1158/0008-5472.Can-07-5547 |
0.407 |
|
| 2008 |
Nephew KP, Osborne E, Lubet RA, Grubbs CJ, Khan SA. Effects of Oral Administration of Tamoxifen, Toremifene, Dehydroepiandrosterone, and Vorozole on Uterine Histomorphology in the Rat Proceedings of the Society For Experimental Biology and Medicine. 223: 288-294. DOI: 10.1046/J.1525-1373.2000.22341.X |
0.308 |
|
| 2007 |
Balch C, Nephew KP, Huang TH, Bapat SA. Epigenetic "bivalently marked" process of cancer stem cell-driven tumorigenesis. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 29: 842-5. PMID 17688287 DOI: 10.1002/Bies.20619 |
0.39 |
|
| 2007 |
Abbosh PH, Li X, Li L, Gardner TA, Kao C, Nephew KP. A conditionally replicative, Wnt/beta-catenin pathway-based adenovirus therapy for anaplastic thyroid cancer. Cancer Gene Therapy. 14: 399-408. PMID 17218945 DOI: 10.1038/Sj.Cgt.7701024 |
0.743 |
|
| 2007 |
Fan M, Rickert EL, Chen L, Aftab SA, Nephew KP, Weatherman RV. Characterization of molecular and structural determinants of selective estrogen receptor downregulators. Breast Cancer Research and Treatment. 103: 37-44. PMID 17033922 DOI: 10.1007/S10549-006-9353-2 |
0.344 |
|
| 2006 |
Fan M, Yan PS, Hartman-Frey C, Chen L, Paik H, Oyer SL, Salisbury JD, Cheng AS, Li L, Abbosh PH, Huang TH, Nephew KP. Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant. Cancer Research. 66: 11954-66. PMID 17178894 DOI: 10.1158/0008-5472.Can-06-1666 |
0.752 |
|
| 2006 |
Abbosh PH, Montgomery JS, Starkey JA, Novotny M, Zuhowski EG, Egorin MJ, Moseman AP, Golas A, Brannon KM, Balch C, Huang TH, Nephew KP. Dominant-negative histone H3 lysine 27 mutant derepresses silenced tumor suppressor genes and reverses the drug-resistant phenotype in cancer cells. Cancer Research. 66: 5582-91. PMID 16740693 DOI: 10.1158/0008-5472.Can-05-3575 |
0.732 |
|
| 2006 |
Wei SH, Balch C, Paik HH, Kim YS, Baldwin RL, Liyanarachchi S, Li L, Wang Z, Wan JC, Davuluri RV, Karlan BY, Gifford G, Brown R, Kim S, Huang TH, ... Nephew KP, et al. Prognostic DNA methylation biomarkers in ovarian cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 2788-94. PMID 16675572 DOI: 10.1158/1078-0432.Ccr-05-1551 |
0.399 |
|
| 2006 |
Long X, Nephew KP. Fulvestrant (ICI 182,780)-dependent interacting proteins mediate immobilization and degradation of estrogen receptor-alpha. The Journal of Biological Chemistry. 281: 9607-15. PMID 16459337 DOI: 10.1074/Jbc.M510809200 |
0.53 |
|
| 2006 |
Cheng AS, Jin VX, Fan M, Smith LT, Liyanarachchi S, Yan PS, Leu YW, Chan MW, Plass C, Nephew KP, Davuluri RV, Huang TH. Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters. Molecular Cell. 21: 393-404. PMID 16455494 DOI: 10.1016/J.Molcel.2005.12.016 |
0.366 |
|
| 2005 |
Chan MW, Wei SH, Wen P, Wang Z, Matei DE, Liu JC, Liyanarachchi S, Brown R, Nephew KP, Yan PS, Huang TH. Hypermethylation of 18S and 28S ribosomal DNAs predicts progression-free survival in patients with ovarian cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 7376-83. PMID 16243810 DOI: 10.1158/1078-0432.Ccr-05-1100 |
0.435 |
|
| 2005 |
Balch C, Yan P, Craft T, Young S, Skalnik DG, Huang TH, Nephew KP. Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer. Molecular Cancer Therapeutics. 4: 1505-14. PMID 16227399 DOI: 10.1158/1535-7163.Mct-05-0216 |
0.424 |
|
| 2005 |
Fan M, Park A, Nephew KP. CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha. Molecular Endocrinology (Baltimore, Md.). 19: 2901-14. PMID 16037132 DOI: 10.1210/Me.2005-0111 |
0.365 |
|
| 2005 |
Abbosh PH, Nephew KP. Multiple signaling pathways converge on beta-catenin in thyroid cancer. Thyroid : Official Journal of the American Thyroid Association. 15: 551-61. PMID 16029121 DOI: 10.1089/Thy.2005.15.551 |
0.712 |
|
| 2005 |
Li L, Shi H, Yiannoutsos C, Huang TH, Nephew KP. Epigenetic hypothesis tests for methylation and acetylation in a triple microarray system. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 12: 370-90. PMID 15857248 DOI: 10.1089/Cmb.2005.12.370 |
0.371 |
|
| 2005 |
Reed CA, Berndtson AK, Nephew KP. Dose-dependent effects of 4-hydroxytamoxifen, the active metabolite of tamoxifen, on estrogen receptor-α expression in the rat uterus Anti-Cancer Drugs. 16: 559-567. PMID 15846122 DOI: 10.1097/00001813-200506000-00012 |
0.323 |
|
| 2005 |
Balch C, Montgomery JS, Paik HI, Kim S, Kim S, Huang TH, Nephew KP. New anti-cancer strategies: epigenetic therapies and biomarkers. Frontiers in Bioscience : a Journal and Virtual Library. 10: 1897-931. PMID 15769674 DOI: 10.2741/1668 |
0.408 |
|
| 2004 |
Jin VX, Leu YW, Liyanarachchi S, Sun H, Fan M, Nephew KP, Huang TH, Davuluri RV. Identifying estrogen receptor alpha target genes using integrated computational genomics and chromatin immunoprecipitation microarray. Nucleic Acids Research. 32: 6627-35. PMID 15608294 DOI: 10.1093/Nar/Gkh1005 |
0.353 |
|
| 2004 |
Leu YW, Yan PS, Fan M, Jin VX, Liu JC, Curran EM, Welshons WV, Wei SH, Davuluri RV, Plass C, Nephew KP, Huang TH. Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer. Cancer Research. 64: 8184-92. PMID 15548683 DOI: 10.1158/0008-5472.Can-04-2045 |
0.447 |
|
| 2004 |
Balch C, Huang TH, Brown R, Nephew KP. The epigenetics of ovarian cancer drug resistance and resensitization. American Journal of Obstetrics and Gynecology. 191: 1552-72. PMID 15547525 DOI: 10.1016/J.Ajog.2004.05.025 |
0.402 |
|
| 2004 |
Fan M, Nakshatri H, Nephew KP. Inhibiting proteasomal proteolysis sustains estrogen receptor-alpha activation. Molecular Endocrinology (Baltimore, Md.). 18: 2603-15. PMID 15284335 DOI: 10.1210/Me.2004-0164 |
0.342 |
|
| 2004 |
Berry NB, Cho YM, Harrington MA, Williams SD, Foley J, Nephew KP. Transcriptional targeting in ovarian cancer cells using the human epididymis protein 4 promoter. Gynecologic Oncology. 92: 896-904. PMID 14984958 DOI: 10.1016/J.Ygyno.2003.12.024 |
0.436 |
|
| 2004 |
Abbosh PH, Nephew KP. 452. Adenoviral Gene Therapy Using CRAd Targeted to Cells with Hyperactive Wnt/|[beta]|-Catenin Signaling Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.404 |
0.738 |
|
| 2003 |
Nephew KP, Huang TH. Epigenetic gene silencing in cancer initiation and progression. Cancer Letters. 190: 125-33. PMID 12565166 DOI: 10.1016/S0304-3835(02)00511-6 |
0.408 |
|
| 2003 |
Fan M, Bigsby RM, Nephew KP. The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182,780 in ERalpha-positive breast cancer cells. Molecular Endocrinology (Baltimore, Md.). 17: 356-65. PMID 12554766 DOI: 10.1210/Me.2002-0323 |
0.415 |
|
| 2002 |
Bailey JA, Nephew KP. Strain differences in tamoxifen sensitivity of Sprague-Dawley and Fischer 344 rats Anti-Cancer Drugs. 13: 939-948. PMID 12394257 DOI: 10.1097/00001813-200210000-00006 |
0.341 |
|
| 2002 |
Fan M, Long X, Bailey JA, Reed CA, Osborne E, Gize EA, Kirk EA, Bigsby RM, Nephew KP. The activating enzyme of NEDD8 inhibits steroid receptor function. Molecular Endocrinology (Baltimore, Md.). 16: 315-30. PMID 11818503 DOI: 10.1210/Mend.16.2.0778 |
0.564 |
|
| 2001 |
Long X, Gize EA, Nephew K, Bigsby RM. Evidence for estrogenic contamination of the MAPK inhibitor PD98059. Endocrinology. 142: 5390-3. PMID 11713241 DOI: 10.1210/Endo.142.12.8649 |
0.531 |
|
| 2001 |
Ahluwalia A, Hurteau JA, Bigsby RM, Nephew KP. DNA methylation in ovarian cancer. II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells. Gynecologic Oncology. 82: 299-304. PMID 11531283 DOI: 10.1006/Gyno.2001.6284 |
0.606 |
|
| 2001 |
Ahluwalia A, Yan P, Hurteau JA, Bigsby RM, Jung SH, Huang TH, Nephew KP. DNA methylation and ovarian cancer. I. Analysis of CpG island hypermethylation in human ovarian cancer using differential methylation hybridization. Gynecologic Oncology. 82: 261-8. PMID 11531277 DOI: 10.1006/Gyno.2001.6291 |
0.586 |
|
| 2001 |
Cárdenas H, Burke KA, Bigsby RM, Pope WF, Nephew KP. Estrogen receptor beta in the sheep ovary during the estrous cycle and early pregnancy. Biology of Reproduction. 65: 128-34. PMID 11420232 DOI: 10.1095/Biolreprod65.1.128 |
0.632 |
|
| 2001 |
Long X, Burke KA, Bigsby RM, Nephew KP. Effects of the xenoestrogen bisphenol A on expression of vascular endothelial growth factor (VEGF) in the rat. Experimental Biology and Medicine (Maywood, N.J.). 226: 477-83. PMID 11393178 DOI: 10.1177/153537020122600514 |
0.549 |
|
| 2001 |
Hlaing M, Nam K, Lou J, Pope WF, Nephew KP. Evidence for expression of estrogen receptor cofactor messenger ribonucleic acid in the ovary and uterus of domesticated animals (sheep, cow and pig). Life Sciences. 68: 1427-38. PMID 11388694 DOI: 10.1016/S0024-3205(01)00937-7 |
0.647 |
|
| 2000 |
Nephew KP, Ray S, Hlaing M, Ahluwalia A, Wu SD, Long X, Hyder SM, Bigsby RM. Expression of estrogen receptor coactivators in the rat uterus. Biology of Reproduction. 63: 361-7. PMID 10906038 DOI: 10.1095/Biolreprod63.2.361 |
0.668 |
|
| 2000 |
Long X, Steinmetz R, Ben-Jonathan N, Caperell-Grant A, Young PC, Nephew KP, Bigsby RM. Strain differences in vaginal responses to the xenoestrogen bisphenol A. Environmental Health Perspectives. 108: 243-7. PMID 10706531 DOI: 10.1289/Ehp.00108243 |
0.537 |
|
| 2000 |
Nephew KP, Long X, Osborne E, Burke KA, Ahluwalia A, Bigsby RM. Effect of estradiol on estrogen receptor expression in rat uterine cell types. Biology of Reproduction. 62: 168-77. PMID 10611082 DOI: 10.1095/Biolreprod62.1.168 |
0.663 |
|
| 1999 |
Nephew KP, Sheeler CQ, Dudley MD, Gordon S, Nayfield SG, Khan SA. Studies of dehydroepiandrosterone (DHEA) with the human estrogen receptor in yeast. Molecular and Cellular Endocrinology. 143: 133-42. PMID 9806358 DOI: 10.1016/S0303-7207(98)00128-2 |
0.308 |
|
| 1994 |
Nephew KP, Cárdenas H, McClure KE, Ott TL, Bazer FW, Pope WF. Effects of administration of human chorionic gonadotropin or progesterone before maternal recognition of pregnancy on blastocyst development and pregnancy in sheep. Journal of Animal Science. 72: 453-8. PMID 8157530 DOI: 10.2527/1994.722453X |
0.616 |
|
| 1993 |
Day ML, Kurz SG, Nephew KP, Wright MD, Hu Y, Ford SP, Pope WF. Influence of catecholestradiol on short-lived corpora lutea in beef cows. Domestic Animal Endocrinology. 10: 95-102. PMID 8391961 DOI: 10.1016/0739-7240(93)90015-4 |
0.591 |
|
| 1992 |
Nephew KP, Xie S, Broermann-Ridder DM, McClure KE, Pope WF. Influence of the embryo on intrauterine migration in sheep. Journal of Animal Science. 70: 1911-5. PMID 1634415 DOI: 10.2527/1992.7061911X |
0.619 |
|
| 1991 |
Nephew KP, McClure KE, Ott TL, Dubois DH, Bazer FW, Pope WF. Relationship between variation in conceptus development and differences in estrous cycle duration in ewes. Biology of Reproduction. 44: 536-9. PMID 2015370 DOI: 10.1095/Biolreprod44.3.536 |
0.609 |
|
| 1991 |
Hu Y, Nephew KP, Pope WF, Day ML. Uterine influences on the formation of subnormal corpora lutea in seasonally anestrous ewes. Journal of Animal Science. 69: 2532-7. PMID 1885368 DOI: 10.2527/1991.6962532X |
0.616 |
|
| 1990 |
Broermann DM, Xie S, Nephew KP, Pope WF. Limitations of oviductal transfers in swine. Theriogenology. 33: 709-21. PMID 16726767 DOI: 10.1016/0093-691X(90)90548-8 |
0.604 |
|
| 1990 |
Xie S, Broermann DM, Nephew KP, Bishop MD, Pope WF. Relationship between oocyte maturation and fertilization on zygotic diversity in swine. Journal of Animal Science. 68: 2027-33. PMID 2384393 DOI: 10.2527/1990.6872027X |
0.602 |
|
| 1990 |
Xie S, Broermann DM, Nephew KP, Geisert RD, Pope WF. Ovulation and early embryogenesis in swine. Biology of Reproduction. 43: 236-40. PMID 2378935 DOI: 10.1095/Biolreprod43.2.236 |
0.615 |
|
| 1990 |
Xie S, Broermann DM, Nephew KP, Ottobre JS, Day ML, Pope WF. Changes in follicular endocrinology during final maturation of porcine oocytes. Domestic Animal Endocrinology. 7: 75-82. PMID 2311376 DOI: 10.1016/0739-7240(90)90056-6 |
0.616 |
|
| 1990 |
Nephew KP, McClure KE, Day ML, Xie S, Roberts RM, Pope WF. Effects of intramuscular administration of recombinant bovine interferon-alpha I1 during the period of maternal recognition of pregnancy. Journal of Animal Science. 68: 2766-70. PMID 2211405 DOI: 10.2527/1990.6892766X |
0.612 |
|
| 1989 |
Nephew KP, McClure KE, Pope WF. Embryonic migration relative to maternal recognition of pregnancy in sheep. Journal of Animal Science. 67: 999-1005. PMID 2715124 DOI: 10.2527/Jas1989.674999X |
0.616 |
|
| 1989 |
Broermann DM, Xie S, Nephew KP, Pope WF. Effects of the oviduct and wheat germ agglutinin on enzymatic digestion of porcine zona pellucidae. Journal of Animal Science. 67: 1324-9. PMID 2661516 DOI: 10.2527/Jas1989.6751324X |
0.625 |
|
| 1989 |
Nephew KP, Ford SP, Day ML, Pope WF. Extension of short cycles in postpartum beef cows by intrauterine treatment with catecholestradiol. Domestic Animal Endocrinology. 6: 363-70. PMID 2620506 DOI: 10.1016/0739-7240(89)90030-1 |
0.619 |
|
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