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Patricia Ernst - Publications

Affiliations: 
2004-2014 Biochemistry Dartmouth College, Hanover, NH, United States 
 2014- University of Colorado School of Medicine, Aurora, CO, United States 
Area:
Genetics, Molecular Biology, Cell Biology
Website:
http://www.ucdenver.edu/academics/colleges/medicalschool/departments/medicine/Hematology/bloodcancerandbmtprogram/people/faculty/Pages/Patricia-Ernst.aspx
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67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Sparbier CE, Gillespie A, Gomez J, Kumari N, Motazedian A, Chan KL, Bell CC, Gilan O, Chan YC, Popp S, Gough DJ, Eckersley-Maslin MA, Dawson SJ, Lehner PJ, Sutherland KD, ... Ernst P, et al. Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes. Nature Cell Biology. PMID 36635503 DOI: 10.1038/s41556-022-01056-x  0.374
2021 Nguyen N, Gudmundsson KO, Soltis AR, Oakley K, Roy KR, Han Y, Gurnari C, Maciejewski JP, Crouch G, Ernst P, Dalgard CL, Du Y. Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation. Iscience. 25: 103679. PMID 35036869 DOI: 10.1016/j.isci.2021.103679  0.366
2021 Libbrecht C, Xie HM, Kingsley MC, Haladyna JN, Riedel SS, Alikarami F, Lenard A, McGeehan GM, Ernst P, Bernt KM. Menin is necessary for long term maintenance of meningioma-1 driven leukemia. Leukemia. PMID 33542482 DOI: 10.1038/s41375-021-01146-z  0.303
2020 Yang W, Trahan GD, Howell ED, Speck NA, Jones KL, Gillen AE, Riemondy K, Hesselberth J, Bryder D, Ernst P. Enhancing Hematopoiesis from Murine Embryonic Stem Cells through MLL1-Induced Activation of a Rac/Rho/Integrin Signaling Axis. Stem Cell Reports. PMID 31951812 DOI: 10.1016/J.Stemcr.2019.12.009  0.448
2019 Addicks GC, Brun CE, Sincennes MC, Saber J, Porter CJ, Francis Stewart A, Ernst P, Rudnicki MA. MLL1 is required for PAX7 expression and satellite cell self-renewal in mice. Nature Communications. 10: 4256. PMID 31534153 DOI: 10.1038/S41467-019-12086-9  0.487
2019 Hurtz C, Chan LN, Geng H, Ballabio E, Xiao G, Deb G, Khoury H, Chen CW, Armstrong SA, Chen J, Ernst P, Melnick A, Milne T, Müschen M. Rationale for targeting BCL6 in -rearranged acute lymphoblastic leukemia. Genes & Development. PMID 31395741 DOI: 10.1101/Gad.327593.119  0.419
2019 Chen Y, Ernst P. Hematopoietic transformation in the absence of MLL1/KMT2A: distinctions in target gene reactivation. Cell Cycle (Georgetown, Tex.). 1-7. PMID 31161857 DOI: 10.1080/15384101.2019.1618642  0.525
2019 Chan LN, Hurtz C, Geng H, Ballabio E, Xiao G, Deb G, Khoury H, Armstrong SA, Ernst P, Melnick A, Milne TA, Müschen M. Rationale for Targeting BCL6 in MLL-Rearranged B-ALL Blood. 134: 1239-1239. DOI: 10.1182/Blood-2019-131565  0.388
2019 Vu T, Liao W, Yang W, Tandon I, Ernst P. REVISITING THE NF-KAPPAB AXIS IN MLL-REARRANGED LEUKEMIA Experimental Hematology. 76: S91. DOI: 10.1016/J.Exphem.2019.06.454  0.41
2019 Ernst P, Bryder D, Jones K, Trahan D, Yang W. AN MLL1-REGULATED RAC/RHO/INTEGRIN SIGNALING AXIS ENHANCES HEMATOPOIESIS FROM EMBRYONIC HEMOGENIC ENDOTHELIAL PRECURSORS Experimental Hematology. 76: S65. DOI: 10.1016/J.Exphem.2019.06.353  0.465
2018 Chen Y, Jones KL, Anastassiadis K, Kranz A, Stewart AF, Grembecka J, Meyerson M, Ernst P. Distinct Pathways Affected by Menin versus MLL1/MLL2 in MLL-rearranged Acute Myeloid Leukemia. Experimental Hematology. PMID 30315824 DOI: 10.1016/J.Exphem.2018.10.001  0.402
2018 Gan T, Li BE, Mishra BP, Jones KL, Ernst P. MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation. Journal of Immunology (Baltimore, Md. : 1950). PMID 29351999 DOI: 10.4049/Jimmunol.1701572  0.399
2017 Chen Y, Anastassiadis K, Kranz A, Stewart AF, Arndt K, Waskow C, Yokoyama A, Jones K, Neff T, Lee Y, Ernst P. MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia. Cancer Cell. 31: 755-770.e6. PMID 28609655 DOI: 10.1016/J.Ccell.2017.05.002  0.445
2017 Yang W, Ernst P. Distinct functions of histone H3, lysine 4 methyltransferases in normal and malignant hematopoiesis. Current Opinion in Hematology. PMID 28375985 DOI: 10.1097/Moh.0000000000000346  0.371
2017 Ernst P, Chen Y. MLL family histone methyltransferases in hematopoiesis and leukemia Experimental Hematology. 53. DOI: 10.1016/J.Exphem.2017.06.026  0.305
2016 Xu H, Valerio DG, Eisold ME, Sinha A, Koche RP, Hu W, Chen CW, Chu SH, Brien GL, Park CY, Hsieh JJ, Ernst P, Armstrong SA. NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis. Cancer Cell. PMID 27889185 DOI: 10.1016/J.Ccell.2016.10.019  0.496
2016 Lin W, Francis JM, Li H, Gao X, Pedamallu CS, Ernst P, Meyerson M. Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets. Cancer Biology & Therapy. 0. PMID 27801610 DOI: 10.1080/15384047.2016.1250986  0.326
2016 Yang W, Ernst P. SET/MLL family proteins in hematopoiesis and leukemia. International Journal of Hematology. PMID 27796741 DOI: 10.1007/S12185-016-2118-8  0.352
2016 Shen EY, Jiang Y, Javidfar B, Kassim B, Loh YH, Ma Q, Mitchell AC, Pothula V, Stewart AF, Ernst P, Yao WD, Martin G, Shen L, Jakovcevski M, Akbarian S. Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs and Increased Anxiety. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27485686 DOI: 10.1038/Npp.2016.144  0.377
2016 Watanabe T, Ernst P. Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL-AF9-Initiated Leukemia. Cancer Cell. 30: 3-5. PMID 27411579 DOI: 10.1016/J.Ccell.2016.06.011  0.389
2016 Riedel SS, Haladyna JN, Bezzant M, Stevens B, Pollyea DA, Sinha AU, Armstrong SA, Wei Q, Pollock RM, Daigle SR, Jordan CT, Ernst P, Neff T, Bernt KM. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia. The Journal of Clinical Investigation. PMID 26927674 DOI: 10.1172/Jci80825  0.45
2016 Hurtz C, Chan LN, Ballabio E, Willman CL, Carroll WL, Armstrong SA, Ernst P, Melnick A, Milne T, Müschen M. Oncogenic Feedback Activation Between BCL6 and MLL Promotes Malignant Transformation in MLL-RearrangedAcute Lymphoblastic Leukemia Blood. 128: 907-907. DOI: 10.1182/Blood.V128.22.907.907  0.394
2016 Ernst P, Anastassiadis K, Kranz A, Stewart AF, Arndt K, Waskow C, Yokoyama A, Jones K, Neff T, Chen Y. The Role of MLL1 and MLL2 in MLL Fusion Oncoprotein-Initiated Leukemia Blood. 128: 573-573. DOI: 10.1182/Blood.V128.22.573.573  0.494
2016 Riedel S, Haladyna J, Stevens B, Pollyea D, Wei Q, Jordan C, Ernst P, Neff T, Bernt K. Abstract IA11: Meningioma-1 cooperates with MLL and DOT1L to induce leukemia Cancer Research. 76. DOI: 10.1158/1538-7445.Pedca15-Ia11  0.461
2016 Ernst P, Chen Y, Anastassiadis K, Krantz A, Yokoyama A, Stewart AF, Neff T, Jones K. Role of endogenous histone methyltransferases in leukemia Experimental Hematology. 44: S42. DOI: 10.1016/J.Exphem.2016.06.044  0.354
2015 Harte PJ, Ernst P. Harnessing gene repression to inhibit leukemia. Nature Medicine. 21: 308-10. PMID 25849269 DOI: 10.1038/Nm.3834  0.405
2015 Jakovcevski M, Ruan H, Shen EY, Dincer A, Javidfar B, Ma Q, Peter CJ, Cheung I, Mitchell AC, Jiang Y, Lin CL, Pothula V, Stewart AF, Ernst P, Yao WD, et al. Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 5097-108. PMID 25834037 DOI: 10.1523/Jneurosci.3004-14.2015  0.343
2015 Riedel S, Haladyna J, Stevens B, Jordan CT, Pollyea D, Armstrong SA, Wei Q, Ernst P, Neff T, Bernt KM. Meningeoma-1 Cooperates with MLL and DOT1L to Induce Leukemia Blood. 126: 2428-2428. DOI: 10.1182/Blood.V126.23.2428.2428  0.455
2015 Chen Y, Li B, Yokoyama A, Ernst P. Endogenous MLL1 is dispensable for MLL-rearranged leukemia, but promotes acute leukemia driven by other oncoproteins Experimental Hematology. 43. DOI: 10.1016/J.Exphem.2015.06.117  0.349
2014 Bharadwaj R, Peter CJ, Jiang Y, Roussos P, Vogel-Ciernia A, Shen EY, Mitchell AC, Mao W, Whittle C, Dincer A, Jakovcevski M, Pothula V, Rasmussen TP, Giakoumaki SG, Bitsios P, ... ... Ernst P, et al. Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition. Neuron. 84: 997-1008. PMID 25467983 DOI: 10.1016/J.Neuron.2014.10.032  0.412
2014 Li BE, Ernst P. Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia. Experimental Hematology. 42: 995-1012. PMID 25264566 DOI: 10.1016/J.Exphem.2014.09.006  0.431
2014 Mishra BP, Zaffuto KM, Artinger EL, Org T, Mikkola HK, Cheng C, Djabali M, Ernst P. The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis. Cell Reports. 7: 1239-47. PMID 24813891 DOI: 10.1016/J.Exphem.2014.07.061  0.787
2014 Chen Y, Li B, Mishra B, Ernst P. Endogenous MLL1 is dispensable for the maintenance of MLL-rearranged leukemia Experimental Hematology. 42. DOI: 10.1016/J.Exphem.2014.07.101  0.382
2013 Artinger EL, Ernst P. Cell context in the control of self-renewal and proliferation regulated by MLL1. Cell Cycle (Georgetown, Tex.). 12: 2969-72. PMID 23974107 DOI: 10.4161/Cc.26032  0.797
2013 Li BE, Gan T, Meyerson M, Rabbitts TH, Ernst P. Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells. Blood. 122: 2039-46. PMID 23908472 DOI: 10.1182/Blood-2013-03-486647  0.516
2013 Huang LH, Gui J, Artinger E, Craig R, Berwin BL, Ernst PA, Chang CC, Chang TY. Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 2081-7. PMID 23846496 DOI: 10.1161/Atvbaha.112.301080  0.765
2013 Artinger EL, Mishra BP, Zaffuto KM, Li BE, Chung EK, Moore AW, Chen Y, Cheng C, Ernst P. An MLL-dependent network sustains hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 12000-5. PMID 23744037 DOI: 10.1073/Pnas.1301278110  0.801
2013 Zorko NA, Yanes DA, Lewis WC, Brook DL, Bernot KM, Siebenaler RF, Whitman SP, Ahmed EH, McConnell KK, Nemer J, Ernst P, Huang G, Marcucci G, Caligiuri MA. Abstract 3849: The partial tandem duplication of Mll (Mll PTD) is a gain-of-function in the absence of Mll wildtype (Mll WT) in adult mouse hematopoiesis. Cancer Research. 73: 3849-3849. DOI: 10.1158/1538-7445.Am2013-3849  0.369
2013 Artinger E, Mishra B, Li B, Zaffuto K, Cheng C, Org T, Mikkola H, Djabali M, Ernst P. MLL1-dependent pathways and mechanisms that maintain hematopoiesis Experimental Hematology. 41: S20. DOI: 10.1016/J.Exphem.2013.05.074  0.738
2012 Ernst P, Vakoc CR. WRAD: enabler of the SET1-family of H3K4 methyltransferases. Briefings in Functional Genomics. 11: 217-26. PMID 22652693 DOI: 10.1093/Bfgp/Els017  0.349
2012 Ernst P, Artinger EL, Mishra BP, Zaffuto KM, Li BE, Chen Y. Coordinating Self-Renewal and Proliferation via MLL1-HOX Pathways and Beyond Blood. 120: SCI-28-SCI-28. DOI: 10.1182/Blood.V120.21.Sci-28.Sci-28  0.811
2011 Cai X, Gaudet JJ, Mangan JK, Chen MJ, De Obaldia ME, Oo Z, Ernst P, Speck NA. Runx1 loss minimally impacts long-term hematopoietic stem cells. Plos One. 6: e28430. PMID 22145044 DOI: 10.1371/Journal.Pone.0028430  0.459
2010 Gan T, Jude CD, Zaffuto K, Ernst P. Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis Leukemia. 24: 1732-1741. PMID 20724987 DOI: 10.1038/Leu.2010.171  0.45
2010 Thiel AT, Blessington P, Zou T, Feather D, Wu X, Yan J, Zhang H, Liu Z, Ernst P, Koretzky GA, Hua X. MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. Cancer Cell. 17: 148-59. PMID 20159607 DOI: 10.1016/J.Ccr.2009.12.034  0.427
2009 Lim DA, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A. Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Nature. 458: 529-33. PMID 19212323 DOI: 10.1038/Nature07726  0.532
2009 Robinson BW, Song Y, Germano G, Ernst P, Abrams J, Scott M, Kugath A, Helfrich M, Sunyer JO, Rhodes J, Balice-Gordon R, Felix CA. Zebrafish Mll Depletion Model Phenocopies Mammalian Mll Depletion and Implicates MLL as Master Regulator of Novel Developmental Hematopoietic Targets. Blood. 114: 3655-3655. DOI: 10.1182/Blood.V114.22.3655.3655  0.517
2009 Ernst P. Hematopoietic stem cells Molecular Basis of Hematopoiesis. 1-22. DOI: 10.1007/978-0-387-85816-6_1  0.36
2008 Jude CD, Gaudet JJ, Speck NA, Ernst P. Leukemia and hematopoietic stem cells: balancing proliferation and quiescence. Cell Cycle (Georgetown, Tex.). 7: 586-91. PMID 18239455 DOI: 10.4161/Cc.7.5.5549  0.538
2007 Jude CD, Climer L, Xu D, Artinger E, Fisher JK, Ernst P. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell. 1: 324-37. PMID 18371366 DOI: 10.1016/J.Stem.2007.05.019  0.778
2006 Bansal D, Scholl C, Fröhling S, McDowell E, Lee BH, Döhner K, Ernst P, Davidson AJ, Daley GQ, Zon LI, Gilliland DG, Huntly BJ. Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. Proceedings of the National Academy of Sciences of the United States of America. 103: 16924-9. PMID 17068127 DOI: 10.1182/Blood.V108.11.10.10  0.488
2005 Wang Y, Yates F, Naveiras O, Ernst P, Daley GQ. Embryonic stem cell-derived hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 19081-6. PMID 16357205 DOI: 10.1073/Pnas.0506127102  0.419
2005 Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA, Akashi K, et al. Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. The Embo Journal. 24: 368-81. PMID 15635450 DOI: 10.1038/Sj.Emboj.7600521  0.597
2004 Ernst P, Mabon M, Davidson AJ, Zon LI, Korsmeyer SJ. An Mll-dependent Hox program drives hematopoietic progenitor expansion. Current Biology : Cb. 14: 2063-9. PMID 15556871 DOI: 10.1016/J.Cub.2004.11.012  0.667
2004 Ernst P, Fisher JK, Avery W, Wade S, Foy D, Korsmeyer SJ. Definitive hematopoiesis requires the mixed-lineage leukemia gene. Developmental Cell. 6: 437-43. PMID 15030765 DOI: 10.1016/S1534-5807(04)00061-9  0.662
2004 Wang Y, Yates F, Dikovskaia E, Ernst P, Davidson AJ, Zon LI, Daley GQ. Derivation of Hematopoietic Stem Cells from Embryonic Stem Cells. Blood. 104: 223-223. DOI: 10.1182/Blood.V104.11.223.223  0.469
2003 Davidson AJ, Ernst P, Wang Y, Dekens MP, Kingsley PD, Palis J, Korsmeyer SJ, Daley GQ, Zon LI. cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature. 425: 300-6. PMID 13679919 DOI: 10.1038/Nature01973  0.63
2003 Hsieh JJ, Ernst P, Erdjument-Bromage H, Tempst P, Korsmeyer SJ. Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Molecular and Cellular Biology. 23: 186-94. PMID 12482972 DOI: 10.1128/Mcb.23.1.186-194.2003  0.55
2002 Ernst P, Wang J, Korsmeyer SJ. The role of MLL in hematopoiesis and leukemia. Current Opinion in Hematology. 9: 282-7. PMID 12042701 DOI: 10.1097/00062752-200207000-00004  0.599
2001 Trinh LA, Ferrini R, Cobb BS, Weinmann AS, Hahm K, Ernst P, Garraway IP, Merkenschlager M, Smale ST. Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator. Genes & Development. 15: 1817-32. PMID 11459831 DOI: 10.1101/Gad.905601  0.747
2001 Ernst P, Wang J, Huang M, Goodman RH, Korsmeyer SJ. MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Molecular and Cellular Biology. 21: 2249-58. PMID 11259575 DOI: 10.1128/Mcb.21.7.2249-2258.2001  0.559
1999 Ernst P, Hahm K, Cobb BS, Brown KE, Trinh LA, McCarty AS, Merkenschlager M, Klug CA, Fisher AG, Smale ST. Mechanisms of transcriptional regulation in lymphocyte progenitors: insight from an analysis of the terminal transferase promoter. Cold Spring Harbor Symposia On Quantitative Biology. 64: 87-97. PMID 11232341 DOI: 10.1101/Sqb.1999.64.87  0.762
1999 Hanson RD, Hess JL, Yu BD, Ernst P, van Lohuizen M, Berns A, van der Lugt NM, Shashikant CS, Ruddle FH, Seto M, Korsmeyer SJ. Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proceedings of the National Academy of Sciences of the United States of America. 96: 14372-7. PMID 10588712 DOI: 10.1073/Pnas.96.25.14372  0.615
1996 Ernst P, Hahm K, Trinh L, Davis JN, Roussel MF, Turck CW, Smale ST. A potential role for Elf-1 in terminal transferase gene regulation. Molecular and Cellular Biology. 16: 6121-31. PMID 8887642 DOI: 10.1128/Mcb.16.11.6121  0.616
1995 Ernst P, Smale ST. Combinatorial regulation of transcription II: The immunoglobulin mu heavy chain gene. Immunity. 2: 427-38. PMID 7749979 DOI: 10.1016/1074-7613(95)90024-1  0.621
1995 Ernst P, Smale ST. Combinatorial regulation of transcription. I: General aspects of transcriptional control. Immunity. 2: 311-9. PMID 7719936 DOI: 10.1016/1074-7613(95)90139-6  0.616
1994 Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST. The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. Molecular and Cellular Biology. 14: 7111-23. PMID 7935426 DOI: 10.1128/Mcb.14.11.7111  0.636
1993 Ernst P, Hahm K, Smale ST. Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene. Molecular and Cellular Biology. 13: 2982-92. PMID 8474456 DOI: 10.1128/Mcb.13.5.2982  0.591
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