| Year |
Citation |
Score |
| 2024 |
de Winter JM, Molenaar JP, Yuen M, van der Pijl R, Shen S, Conijn S, van de Locht M, Willigenburg M, Bogaards SJ, van Kleef ES, Lassche S, Persson M, Rassier DE, Sztal TE, Ruparelia AA, ... ... Granzier H, et al. KBTBD13 is an actin-binding protein that modulates muscle kinetics. The Journal of Clinical Investigation. 134. PMID 38299595 DOI: 10.1172/JCI179111 |
0.45 |
|
| 2023 |
Karimi E, van der Borgh M, Lindqvist J, Gohlke J, Hourani Z, Kolb J, Cossette S, Lawlor MW, Ottenheijm C, Granzier H. Characterization of mutations in patients reveals novel nemaline myopathy disease mechanisms and omecamtiv mecarbil force effects. Biorxiv : the Preprint Server For Biology. PMID 38187705 DOI: 10.1101/2023.12.20.572678 |
0.436 |
|
| 2023 |
Lindqvist J, Granzier H. Pharmacological Inhibition of Myostatin in a Mouse Model of Typical Nemaline Myopathy Increases Muscle Size and Force. International Journal of Molecular Sciences. 24. PMID 37894805 DOI: 10.3390/ijms242015124 |
0.561 |
|
| 2023 |
Slick RA, Tinklenberg JA, Sutton J, Zhang L, Meng H, Beatka M, Avond MV, Prom MJ, Ott E, Montanaro F, Heisner J, Toro R, Granzier H, Geurts AM, Stowe D, et al. Aberrations in Energetic Metabolism and Stress-Related Pathways Contribute to Pathophysiology in the Neb Conditional Knockout Mouse Model of Nemaline Myopathy. The American Journal of Pathology. PMID 37422147 DOI: 10.1016/j.ajpath.2023.06.009 |
0.401 |
|
| 2023 |
Casey JG, Kim ES, Joseph R, Li F, Granzier H, Gupta VA. NRAP reduction rescues sarcomere defects in nebulin-related nemaline myopathy. Human Molecular Genetics. PMID 36661122 DOI: 10.1093/hmg/ddad011 |
0.451 |
|
| 2022 |
van den Berg M, Peters EL, van der Pijl RJ, Shen S, Heunks LMA, Granzier HL, Ottenheijm CAC. Rbm20 Mice, Expressing a Titin Isoform with Lower Stiffness, Are Protected from Mechanical Ventilation-Induced Diaphragm Weakness. International Journal of Molecular Sciences. 23. PMID 36555335 DOI: 10.3390/ijms232415689 |
0.361 |
|
| 2022 |
Ranu N, Laitila J, Dugdale HF, Mariano J, Kolb JS, Wallgren-Pettersson C, Witting N, Vissing J, Vilchez JJ, Fiorillo C, Zanoteli E, Auranen M, Jokela M, Tasca G, Claeys KG, ... ... Granzier H, et al. NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy. Acta Neuropathologica Communications. 10: 185. PMID 36528760 DOI: 10.1186/s40478-022-01491-9 |
0.525 |
|
| 2022 |
Hettige P, Mishra D, Granzier H, Nishikawa K, Gage MJ. Contributions of Titin and Collagen to Passive Stress in Muscles from Mice with a Small Deletion in Titin's Molecular Spring. International Journal of Molecular Sciences. 23. PMID 36012129 DOI: 10.3390/ijms23168858 |
0.443 |
|
| 2022 |
Lindqvist J, Kolb J, de Winter J, Tonino P, Hourani Z, Labeit S, Ottenheijm C, Granzier H. Removal of MuRF1 Increases Muscle Mass in Nemaline Myopathy Models, but Does Not Provide Functional Benefits. International Journal of Molecular Sciences. 23. PMID 35897687 DOI: 10.3390/ijms23158113 |
0.592 |
|
| 2021 |
Biquand A, Spinozzi S, Tonino P, Cosette J, Strom J, Elbeck Z, Knöll R, Granzier H, Lostal W, Richard I. Titin M-Line insertion sequence 7 is required for proper cardiac function in mice. Journal of Cell Science. PMID 34401916 DOI: 10.1242/jcs.258684 |
0.311 |
|
| 2021 |
van der Pijl RJ, van den Berg M, van de Locht M, Shen S, Bogaards SJP, Conijn S, Langlais P, Hooijman PE, Labeit S, Heunks LMA, Granzier H, Ottenheijm CAC. Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator. The Journal of General Physiology. 153. PMID 34152365 DOI: 10.1085/jgp.202112925 |
0.499 |
|
| 2021 |
van de Locht M, Donkervoort S, de Winter JM, Conijn S, Begthel L, Kusters B, Mohassel P, Hu Y, Medne L, Quinn C, Moore SA, Foley AR, Seo G, Hwee DT, Malik FI, ... ... Granzier H, et al. Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium. The Journal of Clinical Investigation. PMID 33755597 DOI: 10.1172/JCI145700 |
0.54 |
|
| 2021 |
Gohlke J, Tonino P, Lindqvist J, Smith JE, Granzier H. The number of Z-repeats and super-repeats in nebulin greatly varies across vertebrates and scales with animal size. The Journal of General Physiology. 153. PMID 33337482 DOI: 10.1085/jgp.202012783 |
0.374 |
|
| 2020 |
Goto K, Schauer A, Augstein A, Methawasin M, Granzier H, Halle M, Craenenbroeck EMV, Rolim N, Gielen S, Pieske B, Winzer EB, Linke A, Adams V. Muscular changes in animal models of heart failure with preserved ejection fraction: what comes closest to the patient? Esc Heart Failure. PMID 33350094 DOI: 10.1002/ehf2.13142 |
0.332 |
|
| 2020 |
Kiss B, Gohlke J, Tonino P, Hourani Z, Kolb J, Strom J, Alekhina O, Smith JE, Ottenheijm C, Gregorio C, Granzier H. Nebulin and Lmod2 are critical for specifying thin-filament length in skeletal muscle. Science Advances. 6. PMID 33177085 DOI: 10.1126/sciadv.abc1992 |
0.516 |
|
| 2020 |
Grogan A, Coleman A, Joca H, Granzier H, Russel MW, Ward CW, Kontrogianni-Konstantopoulos A. Deletion of obscurin immunoglobulin domains Ig58/59 leads to age-dependent cardiac remodeling and arrhythmia. Basic Research in Cardiology. 115: 60. PMID 32910221 DOI: 10.1007/S00395-020-00818-8 |
0.474 |
|
| 2020 |
van der Pijl RJ, Hudson B, Granzier-Nakajima T, Li F, Knottnerus AM, Smith J, Chung CS, Gotthardt M, Granzier HL, Ottenheijm CAC. Deleting Titin's C-Terminal PEVK Exons Increases Passive Stiffness, Alters Splicing, and Induces Cross-Sectional and Longitudinal Hypertrophy in Skeletal Muscle. Frontiers in Physiology. 11: 494. PMID 32547410 DOI: 10.3389/Fphys.2020.00494 |
0.56 |
|
| 2020 |
Lindqvist J, Ma W, Li F, Hernandez Y, Kolb J, Kiss B, Tonino P, van der Pijl R, Karimi E, Gong H, Strom J, Hourani Z, Smith JE, Ottenheijm C, Irving T, ... Granzier H, et al. Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism. Nature Communications. 11: 2699. PMID 32483185 DOI: 10.1038/S41467-020-16526-9 |
0.585 |
|
| 2020 |
Li F, Kolb J, Crudele J, Tonino P, Hourani Z, Smith JE, Chamberlain JS, Granzier H. Correction to: Expressing a Z-disk nebulin fragment innebulin-deficient mouse muscle: effects on muscle structure and function. Skeletal Muscle. 10: 9. PMID 32312330 DOI: 10.1186/S13395-020-00223-8 |
0.503 |
|
| 2020 |
Perrin A, Metay C, Villanova M, Carlier RY, Pegoraro E, Juntas Morales R, Stojkovic T, Richard I, Richard P, Romero NB, Granzier H, Koenig M, Malfatti E, Cossée M. A new congenital multicore titinopathy associated with fast myosin heavy chain deficiency. Annals of Clinical and Translational Neurology. PMID 32307885 DOI: 10.1002/Acn3.51031 |
0.578 |
|
| 2020 |
Lanzicher T, Zhou T, Saripalli C, Keschrumrus V, Smith Iii JE, Mayans O, Sbaizero O, Granzier H. Single-Molecule Force Spectroscopy on the N2A Element of Titin: Effects of Phosphorylation and CARP. Frontiers in Physiology. 11: 173. PMID 32256378 DOI: 10.3389/Fphys.2020.00173 |
0.311 |
|
| 2020 |
Li F, Kolb J, Crudele J, Hourani Z, Smith JE, Chamberlain JS, Granzier H. Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: effects on muscle structure and function. Skeletal Muscle. 10: 2. PMID 31992366 DOI: 10.1186/S13395-019-0219-9 |
0.624 |
|
| 2019 |
Gineste C, Ogier AC, Varlet I, Hourani Z, Bernard M, Granzier H, Bendahan D, Gondin J. In vivo characterization of skeletal muscle function in nebulin-deficient mice. Muscle & Nerve. PMID 31893464 DOI: 10.1002/Mus.26798 |
0.631 |
|
| 2019 |
Lostal W, Roudaut C, Faivre M, Charton K, Suel L, Bourg N, Best H, Smith JE, Gohlke J, Corre G, Li X, Elbek Z, Knoell R, Deschamps JY, Granzier H, et al. Titin splicing regulates cardiotoxicity associated with calpain 3 gene therapy for limb-girdle muscular dystrophy type 2A. Science Translational Medicine. 11. PMID 31776291 DOI: 10.1126/Scitranslmed.Aat6072 |
0.421 |
|
| 2019 |
Lindqvist J, Lee EJ, Karimi E, Kolb J, Granzier H. Omecamtiv mecarbil lowers the contractile deficit in a mouse model of nebulin-based nemaline myopathy. Plos One. 14: e0224467. PMID 31721788 DOI: 10.1371/Journal.Pone.0224467 |
0.473 |
|
| 2019 |
de Winter JM, Molenaar JP, Yuen M, van der Pijl R, Shen S, Conijn S, van de Locht M, Willigenburg M, Bogaards SJ, van Kleef ES, Lassche S, Persson M, Rassier DE, Sztal TE, Ruparelia AA, ... ... Granzier H, et al. KBTBD13 is an actin-binding protein that modulates muscle kinetics. The Journal of Clinical Investigation. PMID 31671076 DOI: 10.1172/Jci124000 |
0.637 |
|
| 2019 |
Lee EJ, Kolb J, Hwee DT, Malik FI, Granzier HL. Functional Characterization of the Intact Diaphragm in a Nebulin-Based Nemaline Myopathy (NM) Model-Effects of the Fast Skeletal Muscle Troponin Activator . International Journal of Molecular Sciences. 20. PMID 31658633 DOI: 10.3390/ijms20205008 |
0.495 |
|
| 2019 |
Qiu B, Ruston J, Granzier H, Justice MJ, Dowling JJ. Failure to identify modifiers of -related nemaline myopathy in two pre-clinical models of the disease. Biology Open. 8. PMID 31530540 DOI: 10.1242/Bio.044867 |
0.358 |
|
| 2019 |
Ross JA, Levy Y, Ripolone M, Kolb JS, Turmaine M, Holt M, Lindqvist J, Claeys KG, Weis J, Monforte M, Tasca G, Moggio M, Figeac N, Zammit PS, Jungbluth H, ... ... Granzier H, et al. Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy. Acta Neuropathologica. PMID 31218456 DOI: 10.1007/S00401-019-02034-8 |
0.575 |
|
| 2019 |
van der Pijl RJ, Granzier H, Ottenheijm CAC. Diaphragm contractile weakness due to altered mechanical loading: role of titin. American Journal of Physiology. Cell Physiology. PMID 31042425 DOI: 10.1152/ajpcell.00509.2018 |
0.5 |
|
| 2019 |
Mijailovich SM, Stojanovic B, Nedic D, Svicevic M, Geeves MA, Irving TC, Granzier HL. Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity. The Journal of General Physiology. PMID 30948421 DOI: 10.1085/Jgp.201812165 |
0.569 |
|
| 2019 |
Kellermayer D, Smith JE, Granzier H. Titin mutations and muscle disease. Pflugers Archiv : European Journal of Physiology. PMID 30919088 DOI: 10.1007/S00424-019-02272-5 |
0.508 |
|
| 2019 |
Ma W, Gong H, Kiss B, Lee EJ, Granzier H, Irving T. Response to: Thick Filament Length Changes in Muscle Have Both Elastic and Structural Components. Biophysical Journal. PMID 30850114 DOI: 10.1016/J.Bpj.2019.02.010 |
0.438 |
|
| 2019 |
Radke MH, Polack C, Methawasin M, Fink C, Granzier HL, Gotthardt M. Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes. Circulation. PMID 30700140 DOI: 10.1161/CIRCULATIONAHA.118.037588 |
0.343 |
|
| 2019 |
Li F, Barton ER, Granzier H. Deleting nebulin's C-terminus reveals its importance to sarcomeric structure and function and is sufficient to invoke nemaline myopathy. Human Molecular Genetics. PMID 30689900 DOI: 10.1093/Hmg/Ddz016 |
0.527 |
|
| 2019 |
Slater RE, Strom JG, Methawasin M, Liss M, Gotthardt M, Sweitzer N, Granzier HL. Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance. The Journal of General Physiology. 151: 42-52. PMID 30567709 DOI: 10.1085/jgp.201812259 |
0.388 |
|
| 2019 |
Brynnel A, Hernandez Y, Kiss B, Lindqvist J, Adler M, Kolb J, Pijl RVd, Gohlke J, Strom J, Smith JE, Granzier HL. Downsizing the Giant Titin Reveals its Dominant Roles in Skeletal Muscle Passive Stiffness and Longitudinal Hypertrophy Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.2178 |
0.568 |
|
| 2018 |
Tinklenberg JA, Siebers EM, Beatka MJ, Fickau BA, Ayres S, Meng H, Yang L, Simpson P, Granzier HL, Lawlor MW. Myostatin Inhibition Using ActRIIB-mFc Does Not Produce Weight Gain or Strength in the Nebulin Conditional KO Mouse. Journal of Neuropathology and Experimental Neurology. PMID 30597051 DOI: 10.1093/jnen/nly120 |
0.302 |
|
| 2018 |
Brynnel A, Hernandez Y, Kiss B, Lindqvist J, Adler M, Kolb J, van der Pijl R, Gohlke J, Strom J, Smith J, Ottenheijm C, Granzier HL. Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy. Elife. 7. PMID 30565562 DOI: 10.7554/eLife.40532 |
0.599 |
|
| 2018 |
Kawai M, Karam TS, Kolb J, Wang L, Granzier HL. Nebulin increases thin filament stiffness and force per cross-bridge in slow-twitch soleus muscle fibers. The Journal of General Physiology. PMID 30301869 DOI: 10.1085/jgp.201812104 |
0.321 |
|
| 2018 |
Ma W, Gong H, Kiss B, Lee EJ, Granzier H, Irving T. Thick-Filament Extensibility in Intact Skeletal Muscle. Biophysical Journal. PMID 30266320 DOI: 10.1016/J.Bpj.2018.08.038 |
0.466 |
|
| 2018 |
Kiss B, Lee EJ, Ma W, Li FW, Tonino P, Mijailovich SM, Irving TC, Granzier HL. Nebulin stiffens the thin filament and augments cross-bridge interaction in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. PMID 30249654 DOI: 10.1073/Pnas.1804726115 |
0.58 |
|
| 2018 |
van der Pijl R, Strom J, Conijn S, Lindqvist J, Labeit S, Granzier H, Ottenheijm C. Titin-based mechanosensing modulates muscle hypertrophy. Journal of Cachexia, Sarcopenia and Muscle. PMID 29978560 DOI: 10.1002/jcsm.12319 |
0.48 |
|
| 2018 |
Methawasin M, Strom J, Helmes M, Granzier H. Abstract 440: The Cardiomyocyte Diastolic Stiffness and Contractility are Inversely Related to the Size of Titin: A Cellular Work Loop Study of Single Intact Cardiomyocytes Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.440 |
0.306 |
|
| 2018 |
Kiss B, Lee E, Ma W, Li F, Tonino P, Mijailovich SM, Irving T, Granzier H. Nebulin Stiffens the Thin Filament and Augments Crossbridge Interaction - An X-Ray Diffraction Study on Intact Muscle Biophysical Journal. 114: 645a. DOI: 10.1016/J.Bpj.2017.11.3482 |
0.451 |
|
| 2018 |
Granzier H, Tonino P, Kiss B, Strom J, Smith J, Methawasin M, Kolb J. The Giant Protein Titin Regulates the Length of the Striated Muscle Thick Filament-Titin Rules Biophysical Journal. 114: 496a. DOI: 10.1016/J.Bpj.2017.11.2718 |
0.595 |
|
| 2017 |
Tonino P, Kiss B, Strom J, Methawasin M, Smith JE, Kolb J, Labeit S, Granzier H. The giant protein titin regulates the length of the striated muscle thick filament. Nature Communications. 8: 1041. PMID 29051486 DOI: 10.1038/s41467-017-01144-9 |
0.591 |
|
| 2017 |
Kellermayer D, Smith JE, Granzier H. Novex-3, the tiny titin of muscle. Biophysical Reviews. PMID 28510117 DOI: 10.1007/s12551-017-0261-y |
0.513 |
|
| 2017 |
Hackman P, Savarese M, Bönneman C, Ferreiro A, Beggs A, Gautel M, Davis M, Evangelista T, Glumac JN, Laporte J, Smith J, Richard I, Granzier H, Schneider R, Jungbluth H, et al. P.480 - Establishment of an international database of Titin mutations and their phenotypes – a follow up: 22nd International Congress of the World Muscle Society Neuromuscular Disorders. 27. DOI: 10.1016/J.Nmd.2017.06.519 |
0.488 |
|
| 2017 |
Li K, Methawasin M, Granzier H, John Solaro R, Tanner B, Dong W. Sarcomere Lengthdependent Effects on the Ca 2+ -Troponin Regulation in Skinned Myocardial Fiber from Titin RBM20 Deletion Mice Biophysical Journal. 112: 257a. DOI: 10.1016/J.Bpj.2016.11.1401 |
0.361 |
|
| 2017 |
Ma W, Buck D, Nedrud J, Irving TC, Granzier H. Thick Filament Compliance in Passively Stretched Skeletal Muscle Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.1005 |
0.833 |
|
| 2016 |
Joureau B, de Winter JM, Stam K, Granzier H, Ottenheijm CA. Muscle weakness in respiratory and peripheral skeletal muscles in a mouse model for nebulin-based nemaline myopathy. Neuromuscular Disorders : Nmd. PMID 27890461 DOI: 10.1016/j.nmd.2016.10.004 |
0.581 |
|
| 2016 |
Bogomolovas J, Fleming JR, Anderson BR, Williams R, Lange S, Simon B, Khan MM, Rudolf R, Franke B, Bullard B, Rigden DJ, Granzier H, Labeit S, Mayans O. Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I. Open Biology. 6. PMID 27683155 DOI: 10.1098/rsob.160114 |
0.385 |
|
| 2016 |
Pulcastro HC, Awinda PO, Methawasin M, Granzier H, Dong W, Tanner BC. Increased Titin Compliance Reduced Length-Dependent Contraction and Slowed Cross-Bridge Kinetics in Skinned Myocardial Strips from Rbm (20ΔRRM) Mice. Frontiers in Physiology. 7: 322. PMID 27524973 DOI: 10.3389/Fphys.2016.00322 |
0.468 |
|
| 2016 |
Gigli M, Begay RL, Morea G, Graw SL, Sinagra G, Taylor MR, Granzier H, Mestroni L. A Review of the Giant Protein Titin in Clinical Molecular Diagnostics of Cardiomyopathies. Frontiers in Cardiovascular Medicine. 3: 21. PMID 27493940 DOI: 10.3389/Fcvm.2016.00021 |
0.369 |
|
| 2016 |
Evans JM, Cox ML, Huska J, Li F, Gaitero L, Guo LT, Casal ML, Granzier HL, Shelton GD, Clark LA. Exome sequencing reveals a nebulin nonsense mutation in a dog model of nemaline myopathy. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 27215641 DOI: 10.1007/S00335-016-9644-9 |
0.44 |
|
| 2016 |
Birch C, Behunin S, Lopez-Pier M, Danilo C, Lipovka Y, Saripalli C, Granzier H, Konhilas JP. Sex-dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy mice. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00592.2015. PMID 27199124 DOI: 10.1152/Ajpheart.00592.2015 |
0.337 |
|
| 2016 |
Kolb J, Li F, Methawasin M, Adler M, Escobar YN, Nedrud J, Pappas CT, Harris SP, Granzier H. Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin. Journal of Molecular and Cellular Cardiology. PMID 27139341 DOI: 10.1016/J.Yjmcc.2016.04.013 |
0.472 |
|
| 2016 |
de Winter JM, Joureau B, Lee EJ, Kiss B, Yuen M, Gupta VA, Pappas CT, Gregorio CC, Stienen GJ, Edvardson S, Wallgren-Pettersson C, Lehtokari VL, Pelin K, Malfatti E, Romero NB, ... ... Granzier H, et al. Mutation-specific effects on thin filament length in thin filament myopathy. Annals of Neurology. PMID 27074222 DOI: 10.1002/Ana.24654 |
0.59 |
|
| 2016 |
Oates E, Yau K, Donkervoort S, Swanson L, Brammah S, Topf A, Richard I, Ferreiro A, Hoffman E, Bushby K, Straub V, Udd B, Lek M, MacArthur D, Granzier H, et al. Analysis of a large international cohort confirms that recessively inherited loss-of-function TTN mutations cause prenatal or infant-onset muscle disease, often complicated by early cardiorespiratory involvement Neuromuscular Disorders. 26. DOI: 10.1016/J.Nmd.2016.06.018 |
0.444 |
|
| 2015 |
Perkin J, Slater R, Del Favero G, Lanzicher T, Hidalgo C, Anderson B, Smith JE, Sbaizero O, Labeit S, Granzier H. Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force. Biophysical Journal. 109: 2592-601. PMID 26682816 DOI: 10.1016/J.Bpj.2015.11.002 |
0.389 |
|
| 2015 |
Leite FS, Minozzo FC, Kalganov A, Cornachione AS, Cheng YS, Leu NA, Han X, Saripalli C, Yates JR, Granzier H, Kashina AS, Rassier DE. Reduced passive force in skeletal muscles lacking protein arginylation. American Journal of Physiology. Cell Physiology. ajpcell.00269.2015. PMID 26511365 DOI: 10.1152/Ajpcell.00269.2015 |
0.513 |
|
| 2015 |
Pappas CT, Mayfield RM, Henderson C, Jamilpour N, Cover C, Hernandez Z, Hutchinson KR, Chu M, Nam KH, Valdez JM, Wong PK, Granzier HL, Gregorio CC. Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality. Proceedings of the National Academy of Sciences of the United States of America. 112: 13573-8. PMID 26487682 DOI: 10.1073/Pnas.1508273112 |
0.347 |
|
| 2015 |
Li F, Buck D, De Winter J, Kolb J, Meng H, Birch C, Slater R, Escobar YN, Smith JE, Yang L, Konhilas J, Lawlor MW, Ottenheijm C, Granzier HL. Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type dependent changes in trophicity--novel insights in nemaline myopathy. Human Molecular Genetics. PMID 26123491 DOI: 10.1093/Hmg/Ddv243 |
0.83 |
|
| 2015 |
de Winter JM, Joureau B, Sequeira V, Clarke NF, van der Velden J, Stienen GJ, Granzier H, Beggs AH, Ottenheijm CA. Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene. Skeletal Muscle. 5: 12. PMID 25949787 DOI: 10.1186/S13395-015-0037-7 |
0.604 |
|
| 2015 |
Hutchinson KR, Saripalli C, Chung CS, Granzier H. Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling. Journal of Molecular and Cellular Cardiology. 79: 104-14. PMID 25450617 DOI: 10.1016/J.Yjmcc.2014.10.020 |
0.403 |
|
| 2015 |
Joureau B, de Winter J, Pappas CT, Malfatti E, Beggs A, Clarke N, Romero N, Gregorio C, Granzier H, Stienen GJ, Ottenheijm CC. Force-Sarcomere Length Relations in Patients with Thin Filament Myopathy Caused by Mutations in NEB, ACTA1, TPM2, TPM3, KBTBD13, KLHL40 and KLHL41 Biophysical Journal. 108: 338a-339a. DOI: 10.1016/J.Bpj.2014.11.1847 |
0.489 |
|
| 2014 |
Meng H, Janssen PM, Grange RW, Yang L, Beggs AH, Swanson LC, Cossette SA, Frase A, Childers MK, Granzier H, Gussoni E, Lawlor MW. Tissue triage and freezing for models of skeletal muscle disease. Journal of Visualized Experiments : Jove. PMID 25078247 DOI: 10.3791/51586 |
0.592 |
|
| 2014 |
Hidalgo C, Saripalli C, Granzier HL. Effect of exercise training on post-translational and post-transcriptional regulation of titin stiffness in striated muscle of wild type and IG KO mice. Archives of Biochemistry and Biophysics. 552: 100-7. PMID 24603287 DOI: 10.1016/J.Abb.2014.02.010 |
0.319 |
|
| 2014 |
Methawasin M, Hutchinson KR, Lee EJ, Smith JE, Saripalli C, Hidalgo CG, Ottenheijm CA, Granzier H. Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole. Circulation. 129: 1924-36. PMID 24599837 DOI: 10.1161/Circulationaha.113.005610 |
0.34 |
|
| 2014 |
Buck D, Smith JE, Chung CS, Ono Y, Sorimachi H, Labeit S, Granzier HL. Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy. The Journal of General Physiology. 143: 215-30. PMID 24470489 DOI: 10.1085/Jgp.201311129 |
0.821 |
|
| 2014 |
Anderson B, Bogomolovas J, Labeit S, Granzier H. Determining the Molecular Mechanisms that Link a Titin Mutation to Cardiomyopathy Biophysical Journal. 106: 774. DOI: 10.1016/J.Bpj.2013.11.4246 |
0.374 |
|
| 2013 |
Ceyhan-Birsoy O, Agrawal PB, Hidalgo C, Schmitz-Abe K, DeChene ET, Swanson LC, Soemedi R, Vasli N, Iannaccone ST, Shieh PB, Shur N, Dennison JM, Lawlor MW, Laporte J, Markianos K, ... ... Granzier H, et al. Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy. Neurology. 81: 1205-14. PMID 23975875 DOI: 10.1212/Wnl.0B013E3182A6Ca62 |
0.463 |
|
| 2013 |
Ottenheijm CA, Buck D, de Winter JM, Ferrara C, Piroddi N, Tesi C, Jasper JR, Malik FI, Meng H, Stienen GJ, Beggs AH, Labeit S, Poggesi C, Lawlor MW, Granzier H. Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy. Brain : a Journal of Neurology. 136: 1718-31. PMID 23715096 DOI: 10.1093/Brain/Awt113 |
0.833 |
|
| 2013 |
de Winter JM, Buck D, Hidalgo C, Jasper JR, Malik FI, Clarke NF, Stienen GJ, Lawlor MW, Beggs AH, Ottenheijm CA, Granzier H. Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations. Journal of Medical Genetics. 50: 383-92. PMID 23572184 DOI: 10.1136/Jmedgenet-2012-101470 |
0.825 |
|
| 2013 |
Lee EJ, De Winter JM, Buck D, Jasper JR, Malik FI, Labeit S, Ottenheijm CA, Granzier H. Fast skeletal muscle troponin activation increases force of mouse fast skeletal muscle and ameliorates weakness due to nebulin-deficiency. Plos One. 8: e55861. PMID 23437068 DOI: 10.1371/Journal.Pone.0055861 |
0.819 |
|
| 2013 |
Gineste C, De Winter JM, Kohl C, Witt CC, Giannesini B, Brohm K, Le Fur Y, Gretz N, Vilmen C, Pecchi E, Jubeau M, Cozzone PJ, Stienen GJ, Granzier H, Labeit S, et al. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Neuromuscular Disorders : Nmd. 23: 357-69. PMID 23375831 DOI: 10.1016/J.Nmd.2012.12.011 |
0.638 |
|
| 2013 |
Lassche S, Stienen GJ, Irving TC, van der Maarel SM, Voermans NC, Padberg GW, Granzier H, van Engelen BG, Ottenheijm CA. Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy. Neurology. 80: 733-7. PMID 23365058 DOI: 10.1212/Wnl.0B013E318282513B |
0.624 |
|
| 2013 |
Lee EJ, Nedrud J, Schemmel P, Gotthardt M, Irving TC, Granzier HL. Calcium sensitivity and myofilament lattice structure in titin N2B KO mice. Archives of Biochemistry and Biophysics. 535: 76-83. PMID 23246787 DOI: 10.1016/J.Abb.2012.12.004 |
0.393 |
|
| 2013 |
Ottenheijm CAC, Buck D, Winter Jd, Ferrara C, Piroddi N, Tesi C, Jasper R, Malik F, Meng F, Stienen G, Beggs AH, Labeit S, Poggesi C, Lawlor M, Granzier H. P.9.10 Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy Neuromuscular Disorders. 23: 786-786. DOI: 10.1016/J.Nmd.2013.06.523 |
0.837 |
|
| 2013 |
Hutchinson K, Chung C, Saripalli C, Hidalgo C, Granzier H. Volume Overload Heart Failure Increases Myocardiac Passive Stiffness in a Mouse Model Biophysical Journal. 104: 157a. DOI: 10.1016/J.Bpj.2012.11.888 |
0.337 |
|
| 2013 |
Ferrara C, Buck D, Piroddi N, Tesi C, LeWinter J, Ottenheijm C, Poggesi C, Granzier H. Altered Cross Bridge Kinetics in Skeletal Myofibrils from NEBΔex55, a Novel Mouse Model of Nebulin-Based Nemaline Myopathy Biophysical Journal. 104: 483-484. DOI: 10.1016/J.Bpj.2012.11.2669 |
0.524 |
|
| 2013 |
Ottenheijm C, Buck D, de Winter J, Lawlor M, Stienen G, Beggs A, Labeit S, Granzier H. A Novel Mouse Model of Nebulin-Based Nemaline Myopathy Biophysical Journal. 104: 38a. DOI: 10.1016/J.Bpj.2012.11.246 |
0.827 |
|
| 2013 |
Buck DE, Chung CS, Smith JE, Granzier HL. Removal of Proximal IG Domains of Titin in Soleus Muscle Results in Differential Splicing of Titin MRNA Biophysical Journal. 104: 310a. DOI: 10.1016/J.Bpj.2012.11.1721 |
0.831 |
|
| 2012 |
Anderson BR, Granzier HL. Titin-based tension in the cardiac sarcomere: molecular origin and physiological adaptations. Progress in Biophysics and Molecular Biology. 110: 204-17. PMID 22910434 DOI: 10.1016/j.pbiomolbio.2012.08.003 |
0.364 |
|
| 2012 |
Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F. A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. The Journal of Biological Chemistry. 287: 29273-84. PMID 22778266 DOI: 10.1074/Jbc.M112.372839 |
0.385 |
|
| 2012 |
Kontrogianni-Konstantopoulos A, Benian G, Granzier H. Advances in Muscle Physiology and Pathophysiology 2011. Journal of Biomedicine & Biotechnology. 2012: 930836. PMID 22570535 DOI: 10.1155/2012/930836 |
0.5 |
|
| 2012 |
Sheikh F, Ouyang K, Campbell SG, Lyon RC, Chuang J, Fitzsimons D, Tangney J, Hidalgo CG, Chung CS, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens JH, ... ... Granzier HL, et al. Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. The Journal of Clinical Investigation. 122: 1209-21. PMID 22426213 DOI: 10.1172/Jci61134 |
0.466 |
|
| 2012 |
Ottenheijm CA, Granzier H, Labeit S. The sarcomeric protein nebulin: another multifunctional giant in charge of muscle strength optimization. Frontiers in Physiology. 3: 37. PMID 22375125 DOI: 10.3389/Fphys.2012.00037 |
0.64 |
|
| 2012 |
van Hees HW, Schellekens WJ, Andrade Acuña GL, Linkels M, Hafmans T, Ottenheijm CA, Granzier HL, Scheffer GJ, van der Hoeven JG, Dekhuijzen PN, Heunks LM. Titin and diaphragm dysfunction in mechanically ventilated rats. Intensive Care Medicine. 38: 702-9. PMID 22327561 DOI: 10.1007/s00134-012-2504-5 |
0.35 |
|
| 2012 |
Ottenheijm CA, Voermans NC, Hudson BD, Irving T, Stienen GJ, van Engelen BG, Granzier H. Titin-based stiffening of muscle fibers in Ehlers-Danlos Syndrome. Journal of Applied Physiology (Bethesda, Md. : 1985). 112: 1157-65. PMID 22223454 DOI: 10.1152/Japplphysiol.01166.2011 |
0.497 |
|
| 2012 |
Lassche S, Stienen GJM, Irving TC, Maarel SMvd, Padberg GW, Granzier H, Ottenheijm CAC, Engelen BGMv. G.P.108 Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy Neuromuscular Disorders. 22: 900-901. DOI: 10.1016/J.Nmd.2012.06.321 |
0.625 |
|
| 2012 |
Hidalgo CG, Methawasin M, Chung CS, Bogomolovas J, Gash A, Labeit S, Mattiazzi A, Granzier H. The Multifunctional Calcium/Calmodulin-Dependent Protein Kinase II Delta (CaMKIIδ) Phosphorylates Titin N2B and PEVK Spring Elements Biophysical Journal. 102: 559a. DOI: 10.1016/J.Bpj.2011.11.3045 |
0.352 |
|
| 2012 |
Anderson BR, Bogomolovas J, Labeit S, Granzier H. Single Molecule Studies of a Titin Mutation Linked to Cardiac Disease Biophysical Journal. 102: 558. DOI: 10.1016/J.Bpj.2011.11.3043 |
0.418 |
|
| 2012 |
Buck DE, Granzier-Nakajima R, Pellegrino JK, Chung CS, Granzier HL. Removal of Ig Domains of Titin Alters Contractility in Mouse Soleus Muscle Biophysical Journal. 102: 360a. DOI: 10.1016/J.Bpj.2011.11.1968 |
0.817 |
|
| 2011 |
Welvaart WN, Paul MA, Stienen GJ, van Hees HW, Loer SA, Bouwman R, Niessen H, de Man FS, Witt CC, Granzier H, Vonk-Noordegraaf A, Ottenheijm CA. Selective diaphragm muscle weakness after contractile inactivity during thoracic surgery. Annals of Surgery. 254: 1044-9. PMID 21975323 DOI: 10.1097/Sla.0B013E318232E75B |
0.514 |
|
| 2011 |
Nedrud J, Labeit S, Gotthardt M, Granzier H. Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle. Biophysical Journal. 101: 1385-92. PMID 21943419 DOI: 10.1016/j.bpj.2011.06.054 |
0.453 |
|
| 2011 |
Taylor M, Graw S, Sinagra G, Barnes C, Slavov D, Brun F, Pinamonti B, Salcedo EE, Sauer W, Pyxaras S, Anderson B, Simon B, Bogomolovas J, Labeit S, Granzier H, et al. Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes. Circulation. 124: 876-85. PMID 21810661 DOI: 10.1161/Circulationaha.110.005405 |
0.352 |
|
| 2011 |
Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, ... ... Granzier H, et al. Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circulation Research. 109: 758-69. PMID 21799151 DOI: 10.1161/Circresaha.111.245787 |
0.325 |
|
| 2011 |
Lawlor MW, Ottenheijm CA, Lehtokari VL, Cho K, Pelin K, Wallgren-Pettersson C, Granzier H, Beggs AH. Novel mutations in NEB cause abnormal nebulin expression and markedly impaired muscle force generation in severe nemaline myopathy. Skeletal Muscle. 1: 23. PMID 21798101 DOI: 10.1186/2044-5040-1-23 |
0.483 |
|
| 2011 |
Chung CS, Methawasin M, Nelson OL, Radke MH, Hidalgo CG, Gotthardt M, Granzier HL. Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions. Journal of Molecular and Cellular Cardiology. 51: 428-34. PMID 21708170 DOI: 10.1016/J.Yjmcc.2011.06.006 |
0.363 |
|
| 2011 |
Irving T, Wu Y, Bekyarova T, Farman GP, Fukuda N, Granzier H. Thick-filament strain and interfilament spacing in passive muscle: effect of titin-based passive tension. Biophysical Journal. 100: 1499-508. PMID 21402032 DOI: 10.1016/J.Bpj.2011.01.059 |
0.474 |
|
| 2011 |
Ottenheijm CA, Lawlor MW, Stienen GJ, Granzier H, Beggs AH. Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy. Human Molecular Genetics. 20: 2015-25. PMID 21357678 DOI: 10.1093/Hmg/Ddr084 |
0.595 |
|
| 2011 |
Ojima K, Ono Y, Ottenheijm C, Hata S, Suzuki H, Granzier H, Sorimachi H. Non-proteolytic functions of calpain-3 in sarcoplasmic reticulum in skeletal muscles. Journal of Molecular Biology. 407: 439-49. PMID 21295580 DOI: 10.1016/J.Jmb.2011.01.057 |
0.499 |
|
| 2011 |
Labeit S, Ottenheijm CA, Granzier H. Nebulin, a major player in muscle health and disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 822-9. PMID 21115852 DOI: 10.1096/Fj.10-157412 |
0.652 |
|
| 2011 |
Ottenheijm CA, van Hees HW, Heunks LM, Granzier H. Titin-based mechanosensing and signaling: role in diaphragm atrophy during unloading? American Journal of Physiology. Lung Cellular and Molecular Physiology. 300: L161-6. PMID 21075826 DOI: 10.1152/ajplung.00288.2010 |
0.506 |
|
| 2011 |
Granzier H. Novel Insights in the Function of the Giant Sarcomeric Proteins Titin and Nebulin Biophysical Journal. 100: 5-8. DOI: 10.1016/J.Bpj.2010.12.3395 |
0.66 |
|
| 2011 |
Buck D, Tonino P, Hoying A, Granzier H. Thin Filament Length in Mouse Skeletal Muscle and its Relationship to Differential Splicing of Nebulin Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.3388 |
0.835 |
|
| 2011 |
Nedrud J, Gotthardt M, Granzier H. The Role of Titin's N2B Element in Limiting Energy Loss of Mouse Myocardium During Repeated Loading Cycles Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.2682 |
0.421 |
|
| 2011 |
Chung CS, Methawasin M, Nelson OL, Gotthardt M, Granzier HL. Quantification of Titin Based Viscosity: Temperature, Lattice Compression and Integrative Physiology Biophysical Journal. 100: 455a. DOI: 10.1016/J.Bpj.2010.12.2679 |
0.325 |
|
| 2011 |
Lee E, Gotthardt M, Nedrud J, Hudson B, Schemmel P, Hsu H, Irving T, Granzier H. Length Dependence of Activation (LDA) Studies in Mice Deficient in the N2B Element of Titin Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.2678 |
0.378 |
|
| 2010 |
Ottenheijm CA, Granzier H. Lifting the nebula: novel insights into skeletal muscle contractility. Physiology (Bethesda, Md.). 25: 304-10. PMID 20940435 DOI: 10.1152/Physiol.00016.2010 |
0.626 |
|
| 2010 |
Ottenheijm CA, Granzier H. Role of titin in skeletal muscle function and disease. Advances in Experimental Medicine and Biology. 682: 105-22. PMID 20824522 DOI: 10.1007/978-1-4419-6366-6_6 |
0.553 |
|
| 2010 |
Kontrogianni-Konstantopoulos A, Benian G, Granzier H. Advances in muscle physiology and pathophysiology. Journal of Biomedicine & Biotechnology. 2010. PMID 20798778 DOI: 10.1155/2010/780417 |
0.482 |
|
| 2010 |
Labeit S, Kohl CH, Witt CC, Labeit D, Jung J, Granzier H. Modulation of muscle atrophy, fatigue and MLC phosphorylation by MuRF1 as indicated by hindlimb suspension studies on MuRF1-KO mice. Journal of Biomedicine & Biotechnology. 2010: 693741. PMID 20625437 DOI: 10.1155/2010/693741 |
0.58 |
|
| 2010 |
Ojima K, Kawabata Y, Nakao H, Nakao K, Doi N, Kitamura F, Ono Y, Hata S, Suzuki H, Kawahara H, Bogomolovas J, Witt C, Ottenheijm C, Labeit S, Granzier H, et al. Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy. The Journal of Clinical Investigation. 120: 2672-83. PMID 20592470 DOI: 10.1172/Jci40658 |
0.497 |
|
| 2010 |
Ottenheijm CA, Granzier H. New insights into the structural roles of nebulin in skeletal muscle. Journal of Biomedicine & Biotechnology. 2010: 968139. PMID 20589077 DOI: 10.1155/2010/968139 |
0.629 |
|
| 2010 |
Lee EJ, Peng J, Radke M, Gotthardt M, Granzier HL. Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice. Journal of Molecular and Cellular Cardiology. 49: 449-58. PMID 20507834 DOI: 10.1016/j.yjmcc.2010.05.006 |
0.312 |
|
| 2010 |
LeWinter MM, Granzier H. Cardiac titin: a multifunctional giant. Circulation. 121: 2137-45. PMID 20479164 DOI: 10.1161/Circulationaha.109.860171 |
0.393 |
|
| 2010 |
Granzier HL. Activation and stretch-induced passive force enhancement--are you pulling my chain? Focus on "Regulation of muscle force in the absence of actin-myosin-based cross-bridge interaction". American Journal of Physiology. Cell Physiology. 299: C11-3. PMID 20445175 DOI: 10.1152/ajpcell.00147.2010 |
0.396 |
|
| 2010 |
Fukushima H, Chung CS, Granzier H. Titin-isoform dependence of titin-actin interaction and its regulation by S100A1/Ca2+ in skinned myocardium. Journal of Biomedicine & Biotechnology. 2010: 727239. PMID 20414336 DOI: 10.1155/2010/727239 |
0.369 |
|
| 2010 |
Buck D, Hudson BD, Ottenheijm CA, Labeit S, Granzier H. Differential splicing of the large sarcomeric protein nebulin during skeletal muscle development. Journal of Structural Biology. 170: 325-33. PMID 20176113 DOI: 10.1016/J.Jsb.2010.02.014 |
0.821 |
|
| 2010 |
Moriscot AS, Baptista IL, Bogomolovas J, Witt C, Hirner S, Granzier H, Labeit S. MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance. Journal of Structural Biology. 170: 344-53. PMID 20149877 DOI: 10.1016/J.Jsb.2010.02.001 |
0.522 |
|
| 2010 |
Anderson BR, Bogomolovas J, Labeit S, Granzier H. The effects of PKCalpha phosphorylation on the extensibility of titin's PEVK element. Journal of Structural Biology. 170: 270-7. PMID 20149875 DOI: 10.1016/J.Jsb.2010.02.002 |
0.369 |
|
| 2010 |
Lewinter MM, Popper J, McNabb M, Nyland L, Bell SB, Granzier H. Extensible behavior of titin in the miniswine left ventricle. Circulation. 121: 768-74. PMID 20124120 DOI: 10.1161/Circulationaha.109.918151 |
0.363 |
|
| 2010 |
Tonino P, Pappas CT, Hudson BD, Labeit S, Gregorio CC, Granzier H. Reduced myofibrillar connectivity and increased Z-disk width in nebulin-deficient skeletal muscle. Journal of Cell Science. 123: 384-91. PMID 20053633 DOI: 10.1242/Jcs.042234 |
0.493 |
|
| 2010 |
Ottenheijm CA, Hooijman P, DeChene ET, Stienen GJ, Beggs AH, Granzier H. Altered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2). Journal of Structural Biology. 170: 334-43. PMID 19944167 DOI: 10.1016/J.Jsb.2009.11.013 |
0.539 |
|
| 2010 |
van Hees HWH, Ottenheijm CAC, Granzier HL, Dekhuijzen PNR, Heunks LMA. Heart failure decreases passive tension generation of rat diaphragm fibers International Journal of Cardiology. 141: 275-283. PMID 19150150 DOI: 10.1016/j.ijcard.2008.12.042 |
0.319 |
|
| 2010 |
Ojima K, Ono Y, Doi N, Kitamura F, Hata S, Kawabata Y, Suzuki K, Maeda T, Abe K, Nakao H, Aiba A, Nakao K, Suzuki H, Kawahara H, Witt C, ... ... Granzier H, et al. O.5 Skeletal muscle-specific calpain, p94/calpain 3, dynamically distributes in skeletal muscle cells to adapt to physical stress, defects of which cause muscular dystrophy Neuromuscular Disorders. 20: 598-599. DOI: 10.1016/J.Nmd.2010.07.014 |
0.552 |
|
| 2010 |
Anderson B, Bogolomovas J, Labeit S, Granzier H. Single Molecule Analysis of PKC Phosphorylation of Titin's PEVK Domain Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.2993 |
0.371 |
|
| 2010 |
Nedrud J, Gotthardt M, Granzier H. The N2B Element of Cardiac Titin Greatly Reduces Energy Loss During Loading Cycles of the Heart Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.2992 |
0.354 |
|
| 2010 |
Lee E, Hidalgo C, Gotthardt M, Granzier H. Increased Ca2+ Sensitivity and Length Dependent Activation in a Mouse Model with Increased Titin-Based Stiffness Biophysical Journal. 98: 552. DOI: 10.1016/J.Bpj.2009.12.2990 |
0.48 |
|
| 2010 |
Buck D, Hoying A, Hudson B, Ottenheijm C, Granzier H. Developmentally Regulated Differential Splicing of the Large Sarcomeric Proteins Titin and Nebulin Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.2954 |
0.814 |
|
| 2010 |
Hudson BD, Chung CS, Granzier-Nakajima T, Cromer NE, Buck D, Gotthardt M, Granzier H. Effect of Excision of Titin's PEVK Exons 219-225 on Skeletal Muscle Structure and Function Biophysical Journal. 98: 544a-545a. DOI: 10.1016/J.Bpj.2009.12.2953 |
0.832 |
|
| 2010 |
Granzier H. The Giant Elastic Protein Titin Role in Muscle Function and Disease Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.1199 |
0.551 |
|
| 2009 |
Ottenheijm CA, Knottnerus AM, Buck D, Luo X, Greer K, Hoying A, Labeit S, Granzier H. Tuning passive mechanics through differential splicing of titin during skeletal muscle development. Biophysical Journal. 97: 2277-86. PMID 19843460 DOI: 10.1016/J.Bpj.2009.07.041 |
0.829 |
|
| 2009 |
Chandra M, Mamidi R, Ford S, Hidalgo C, Witt C, Ottenheijm C, Labeit S, Granzier H. Nebulin alters cross-bridge cycling kinetics and increases thin filament activation: a novel mechanism for increasing tension and reducing tension cost. The Journal of Biological Chemistry. 284: 30889-96. PMID 19736309 DOI: 10.1074/Jbc.M109.049718 |
0.647 |
|
| 2009 |
Ottenheijm CA, Hidalgo C, Rost K, Gotthardt M, Granzier H. Altered contractility of skeletal muscle in mice deficient in titin's M-band region. Journal of Molecular Biology. 393: 10-26. PMID 19683008 DOI: 10.1016/J.Jmb.2009.08.009 |
0.594 |
|
| 2009 |
Hidalgo C, Hudson B, Bogomolovas J, Zhu Y, Anderson B, Greaser M, Labeit S, Granzier H. PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness. Circulation Research. 105: 631-8, 17 p followin. PMID 19679839 DOI: 10.1161/Circresaha.109.198465 |
0.415 |
|
| 2009 |
Granzier HL, Radke MH, Peng J, Westermann D, Nelson OL, Rost K, King NM, Yu Q, Tschöpe C, McNabb M, Larson DF, Labeit S, Gotthardt M. Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction. Circulation Research. 105: 557-64. PMID 19679835 DOI: 10.1016/J.Bpj.2008.12.2002 |
0.347 |
|
| 2009 |
Gramlich M, Michely B, Krohne C, Heuser A, Erdmann B, Klaassen S, Hudson B, Magarin M, Kirchner F, Todiras M, Granzier H, Labeit S, Thierfelder L, Gerull B. Stress-induced dilated cardiomyopathy in a knock-in mouse model mimicking human titin-based disease. Journal of Molecular and Cellular Cardiology. 47: 352-8. PMID 19406126 DOI: 10.1016/J.Yjmcc.2009.04.014 |
0.432 |
|
| 2009 |
Ottenheijm CA, Witt CC, Stienen GJ, Labeit S, Beggs AH, Granzier H. Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency. Human Molecular Genetics. 18: 2359-69. PMID 19346529 DOI: 10.1093/Hmg/Ddp168 |
0.639 |
|
| 2009 |
Zhu Y, Bogomolovas J, Labeit S, Granzier H. Single molecule force spectroscopy of the cardiac titin N2B element: effects of the molecular chaperone alphaB-crystallin with disease-causing mutations. The Journal of Biological Chemistry. 284: 13914-23. PMID 19282282 DOI: 10.1074/Jbc.M809743200 |
0.39 |
|
| 2009 |
Williams L, Howell N, Pagano D, Andreka P, Vertesaljai M, Pecor T, Frenneaux M, Granzier H. Titin isoform expression in aortic stenosis. Clinical Science (London, England : 1979). 117: 237-42. PMID 19154184 DOI: 10.1042/Cs20080248 |
0.318 |
|
| 2009 |
Ottenheijm C, Knottnerus A, Buck D, Pecor T, Luo X, Granzier H. Titin Isoform Transitions and Passive Stiffness During Skeletal Muscle Development Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.2572 |
0.832 |
|
| 2009 |
King NMP, Helmes M, Granzier H. A Direct Method to Measure the Restoring Force and Slack Sarcomere Length of Intact Cardiomyocytes Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.2571 |
0.379 |
|
| 2008 |
Kramerova I, Kudryashova E, Wu B, Ottenheijm C, Granzier H, Spencer MJ. Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle. Human Molecular Genetics. 17: 3271-80. PMID 18676612 DOI: 10.1093/Hmg/Ddn223 |
0.512 |
|
| 2008 |
Fukuda N, Granzier HL, Ishiwata S, Kurihara S. Physiological functions of the giant elastic protein titin in mammalian striated muscle. The Journal of Physiological Sciences : Jps. 58: 151-9. PMID 18477421 DOI: 10.2170/physiolsci.RV005408 |
0.564 |
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| 2008 |
Ottenheijm CA, Fong C, Vangheluwe P, Wuytack F, Babu GJ, Periasamy M, Witt CC, Labeit S, Granzier H. Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 2912-9. PMID 18434434 DOI: 10.1096/Fj.07-104372 |
0.55 |
|
| 2008 |
Campbell KB, Simpson AM, Campbell SG, Granzier HL, Slinker BK. Dynamic left ventricular elastance: a model for integrating cardiac muscle contraction into ventricular pressure-volume relationships. Journal of Applied Physiology (Bethesda, Md. : 1985). 104: 958-75. PMID 18048589 DOI: 10.1152/japplphysiol.00912.2007 |
0.354 |
|
| 2007 |
Granzier H, Labeit S. Structure-function relations of the giant elastic protein titin in striated and smooth muscle cells. Muscle & Nerve. 36: 740-55. PMID 17763461 DOI: 10.1002/Mus.20886 |
0.636 |
|
| 2007 |
Granzier H, Radke M, Royal J, Wu Y, Irving TC, Gotthardt M, Labeit S. Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 293: R557-67. PMID 17522126 DOI: 10.1152/Ajpregu.00001.2007 |
0.31 |
|
| 2007 |
Radke MH, Peng J, Wu Y, McNabb M, Nelson OL, Granzier H, Gotthardt M. Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy. Proceedings of the National Academy of Sciences of the United States of America. 104: 3444-9. PMID 17360664 DOI: 10.1073/Pnas.0608543104 |
0.402 |
|
| 2007 |
Wu Y, Peng J, Campbell KB, Labeit S, Granzier H. Hypothyroidism leads to increased collagen-based stiffness and re-expression of large cardiac titin isoforms with high compliance. Journal of Molecular and Cellular Cardiology. 42: 186-95. PMID 17069849 DOI: 10.1016/J.Yjmcc.2006.09.017 |
0.449 |
|
| 2007 |
LeWinter MM, Wu Y, Labeit S, Granzier H. Cardiac titin: structure, functions and role in disease. Clinica Chimica Acta; International Journal of Clinical Chemistry. 375: 1-9. PMID 16904093 DOI: 10.1016/J.Cca.2006.06.035 |
0.498 |
|
| 2007 |
Hatakeyama S, Zhu Y, Granzier H, Kimura S. 1P173 Single molecule measurement of elasticity of connectin-like 1200K-protein fragment B in a polychaete (Annelida)(Muscle-muscle proteins and contraction,Poster Presentations) Seibutsu Butsuri. 47: S66. DOI: 10.2142/biophys.47.S66_4 |
0.471 |
|
| 2006 |
Labeit S, Lahmers S, Burkart C, Fong C, McNabb M, Witt S, Witt C, Labeit D, Granzier H. Expression of distinct classes of titin isoforms in striated and smooth muscles by alternative splicing, and their conserved interaction with filamins. Journal of Molecular Biology. 362: 664-81. PMID 16949617 DOI: 10.1016/J.Jmb.2006.07.077 |
0.632 |
|
| 2006 |
Hidalgo C, Wu Y, Peng J, Siems WF, Campbell KB, Granzier H. Effect of diastolic pressure on MLC2v phosphorylation in the rat left ventricle. Archives of Biochemistry and Biophysics. 456: 216-23. PMID 16949549 DOI: 10.1016/J.Abb.2006.06.026 |
0.338 |
|
| 2006 |
Witt CC, Burkart C, Labeit D, McNabb M, Wu Y, Granzier H, Labeit S. Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo. The Embo Journal. 25: 3843-55. PMID 16902413 DOI: 10.1038/sj.emboj.7601242 |
0.477 |
|
| 2006 |
Gerull B, Atherton J, Geupel A, Sasse-Klaassen S, Heuser A, Frenneaux M, McNabb M, Granzier H, Labeit S, Thierfelder L. Identification of a novel frameshift mutation in the giant muscle filament titin in a large Australian family with dilated cardiomyopathy Journal of Molecular Medicine. 84: 478-483. PMID 16733766 DOI: 10.1007/S00109-006-0060-6 |
0.45 |
|
| 2006 |
Granzier HL, Labeit S. The giant muscle protein titin is an adjustable molecular spring Exercise and Sport Sciences Reviews. 34: 50-53. PMID 16672800 DOI: 10.1249/00003677-200604000-00002 |
0.51 |
|
| 2006 |
Hatakeyama S, Izawa N, Zhu Y, Granzier H, Kimura S. 1P235 Single molecule measurement of Elasticity of connectin-like 1200K-protein in obliquely striated muscle of a polychaete (Annelida)(8. Muscle contraction and muscle protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) Seibutsu Butsuri. 46: S205. DOI: 10.2142/BIOPHYS.46.S205_3 |
0.51 |
|
| 2005 |
Peng J, Raddatz K, Labeit S, Granzier H, Gotthardt M. Muscle atrophy in Titin M-line deficient mice Journal of Muscle Research and Cell Motility. 26: 381-388. PMID 16470336 DOI: 10.1007/S10974-005-9020-Y |
0.587 |
|
| 2005 |
Preetha N, Yiming W, Helmes M, Norio F, Siegfried L, Granzier H. Restoring force development by titin/connectin and assessment of Ig domain unfolding. Journal of Muscle Research and Cell Motility. 26: 307-17. PMID 16470334 DOI: 10.1007/S10974-005-9037-2 |
0.443 |
|
| 2005 |
Fukuda N, Granzier HL. Titin/connectin-based modulation of the Frank-Starling mechanism of the heart Journal of Muscle Research and Cell Motility. 26: 319-323. PMID 16453158 DOI: 10.1007/s10974-005-9038-1 |
0.372 |
|
| 2005 |
Witt SH, Labeit D, Granzier H, Labeit S, Witt CC. Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based signaling. Journal of Muscle Research and Cell Motility. 26: 401-8. PMID 16450059 DOI: 10.1007/S10974-005-9022-9 |
0.443 |
|
| 2005 |
Granzier H, Wu Y, Siegfried L, LeWinter M. Titin: physiological function and role in cardiomyopathy and failure. Heart Failure Reviews. 10: 211-23. PMID 16416044 DOI: 10.1007/s10741-005-5251-7 |
0.366 |
|
| 2005 |
Witt SH, Granzier H, Witt CC, Labeit S. MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination. Journal of Molecular Biology. 350: 713-22. PMID 15967462 DOI: 10.1016/J.Jmb.2005.05.021 |
0.541 |
|
| 2005 |
Nagy A, Grama L, Huber T, Bianco P, Trombitás K, Granzier HL, Kellermayer MSZ. Hierarchical extensibility in the PEVK domain of skeletal-muscle titin Biophysical Journal. 89: 329-336. PMID 15849252 DOI: 10.1529/biophysj.104.057737 |
0.391 |
|
| 2005 |
Fukuda N, Wu Y, Nair P, Granzier HL. Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner. The Journal of General Physiology. 125: 257-71. PMID 15738048 DOI: 10.1085/jgp.200409177 |
0.342 |
|
| 2005 |
Fukuda N, Wu Y, Farman G, Irving TC, Granzier H. Titin-based modulation of active tension and interfilament lattice spacing in skinned rat cardiac muscle. PflüGers Archiv : European Journal of Physiology. 449: 449-57. PMID 15688246 DOI: 10.1007/S00424-004-1354-6 |
0.372 |
|
| 2004 |
Fukuda N, Granzier H. Role of the giant elastic protein titin in the Frank-Starling mechanism of the heart Current Vascular Pharmacology. 2: 135-139. PMID 15320514 DOI: 10.2174/1570161043476357 |
0.535 |
|
| 2004 |
Miller MK, Granzier H, Ehler E, Gregorio CC. The sensitive giant: the role of titin-based stretch sensing complexes in the heart. Trends in Cell Biology. 14: 119-26. PMID 15003620 DOI: 10.1016/J.Tcb.2004.01.003 |
0.326 |
|
| 2004 |
Granzier HL, Labeit S. The giant protein titin: a major player in myocardial mechanics, signaling, and disease. Circulation Research. 94: 284-95. PMID 14976139 DOI: 10.1161/01.RES.0000117769.88862.F8 |
0.341 |
|
| 2004 |
Witt CC, Ono Y, Puschmann E, McNabb M, Wu Y, Gotthardt M, Witt SH, Haak M, Labeit D, Gregorio CC, Sorimachi H, Granzier H, Labeit S. Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling. Journal of Molecular Biology. 336: 145-54. PMID 14741210 DOI: 10.1016/J.Jmb.2003.12.021 |
0.635 |
|
| 2004 |
Lahmers S, Wu Y, Call DR, Labeit S, Granzier H. Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium. Circulation Research. 94: 505-13. PMID 14707027 DOI: 10.1161/01.Res.0000115522.52554.86 |
0.398 |
|
| 2003 |
Granzier H, Labeit D, Wu Y, Witt C, Watanabe K, Lahmers S, Gotthardt M, Labeit S. Adaptations in titin's spring elements in normal and cardiomyopathic hearts. Advances in Experimental Medicine and Biology. 538: 517-30; discussion 5. PMID 15098695 |
0.377 |
|
| 2003 |
Labeit D, Watanabe K, Witt C, Fujita H, Wu Y, Lahmers S, Funck T, Labeit S, Granzier H. Calcium-dependent molecular spring elements in the giant protein titin. Proceedings of the National Academy of Sciences of the United States of America. 100: 13716-21. PMID 14593205 DOI: 10.1073/pnas.2235652100 |
0.317 |
|
| 2003 |
Miller MK, Bang ML, Witt CC, Labeit D, Trombitas C, Watanabe K, Granzier H, McElhinny AS, Gregorio CC, Labeit S. The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules. Journal of Molecular Biology. 333: 951-64. PMID 14583192 DOI: 10.1016/J.Jmb.2003.09.012 |
0.552 |
|
| 2003 |
Trombitás K, Wu Y, McNabb M, Greaser M, Kellermayer MSZ, Labeit S, Granzier HL. Molecular Basis of Passive Stress Relaxation in Human Soleus Fibers: Assessment of the Role of Immunoglobulin-like Domain Unfolding Biophysical Journal. 85: 3142-3153. PMID 14581214 DOI: 10.1016/S0006-3495(03)74732-8 |
0.314 |
|
| 2003 |
Fukuda N, Wu Y, Farman G, Irving TC, Granzier H. Titin isoform variance and length dependence of activation in skinned bovine cardiac muscle. The Journal of Physiology. 553: 147-54. PMID 12963792 DOI: 10.1113/Jphysiol.2003.049759 |
0.502 |
|
| 2003 |
Gotthardt M, Hammer RE, Hübner N, Monti J, Witt CC, McNabb M, Richardson JA, Granzier H, Labeit S, Herz J. Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure. The Journal of Biological Chemistry. 278: 6059-65. PMID 12464612 DOI: 10.1074/Jbc.M211723200 |
0.307 |
|
| 2002 |
Granzier H, Labeit D, Wu Y, Labeit S. Titin as a modular spring: emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology. Journal of Muscle Research and Cell Motility. 23: 457-71. PMID 12785097 DOI: 10.1023/A:1023458406346 |
0.6 |
|
| 2002 |
Wu Y, Labeit S, Lewinter MM, Granzier H. Titin: an endosarcomeric protein that modulates myocardial stiffness in DCM. Journal of Cardiac Failure. 8: S276-86. PMID 12555133 DOI: 10.1054/Jcaf.2002.129278 |
0.563 |
|
| 2002 |
Wu Y, Bell SP, Trombitas K, Witt CC, Labeit S, LeWinter MM, Granzier H. Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness. Circulation. 106: 1384-9. PMID 12221057 DOI: 10.1161/01.Cir.0000029804.61510.02 |
0.517 |
|
| 2002 |
Yamasaki R, Wu Y, McNabb M, Greaser M, Labeit S, Granzier H. Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes Circulation Research. 90: 1181-1188. PMID 12065321 DOI: 10.1161/01.Res.0000021115.24712.99 |
0.419 |
|
| 2002 |
Granzier H, Labeit S. Cardiac titin: An adjustable multi-functional spring Journal of Physiology. 541: 335-342. PMID 12042342 DOI: 10.1113/Jphysiol.2001.014381 |
0.492 |
|
| 2002 |
Toursel T, Stevens L, Granzier H, Mounier Y. Passive tension of rat skeletal soleus muscle fibers: Effects of unloading conditions Journal of Applied Physiology. 92: 1465-1472. PMID 11896011 DOI: 10.1152/Japplphysiol.00621.2001 |
0.534 |
|
| 2002 |
Watanabe K, Nair P, Labeit D, Kellermayer MS, Greaser M, Labeit S, Granzier H. Molecular mechanics of cardiac titin's PEVK and N2B spring elements. The Journal of Biological Chemistry. 277: 11549-58. PMID 11799131 DOI: 10.1074/Jbc.M200356200 |
0.382 |
|
| 2002 |
Gerull B, Gramlich M, Atherton J, McNabb M, Trombitás K, Sasse-Klaassen S, Seidman JG, Seidman C, Granzier H, Labeit S, Frenneaux M, Thierfelder L. Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy Nature Genetics. 30: 201-204. PMID 11788824 DOI: 10.1038/Ng815 |
0.488 |
|
| 2002 |
Linke WA, Granzier H, Kellermayer MSZ. Journal of Muscle Research and Cell Motility: Preface Journal of Muscle Research and Cell Motility. 23. |
0.417 |
|
| 2001 |
Muhle-Goll C, Habeck M, Cazorla O, Nilges M, Labeit S, Granzier H. Structural and Functional Studies of Titin's fn3 Modules Reveal Conserved Surface Patterns and Binding to Myosin S1 - A Possible Role in the Frank-Starling Mechanism of the Heart Journal of Molecular Biology. 313: 431-447. PMID 11800567 DOI: 10.1006/Jmbi.2001.5017 |
0.399 |
|
| 2001 |
Bang ML, Centner T, Fornoff F, Geach AJ, Gotthardt M, McNabb M, Witt CC, Labeit D, Gregorio CC, Granzier H, Labeit S. The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system. Circulation Research. 89: 1065-72. PMID 11717165 DOI: 10.1161/Hh2301.100981 |
0.412 |
|
| 2001 |
Yamasaki R, Berri M, Wu Y, Trombitás K, McNabb M, Kellermayer MSZ, Witt C, Labeit D, Labeit S, Greaser M, Granzier H. Titin-actin interaction in mouse myocardium: Passive tension modulation and its regulation by calcium/S100A1 Biophysical Journal. 81: 2297-2313. PMID 11566799 DOI: 10.1016/S0006-3495(01)75876-6 |
0.338 |
|
| 2001 |
Trombitás K, Wu Y, Labeit D, Labeit S, Granzier H. Cardiac titin isoforms are coexpressed in the half-sarcomere and extend independently American Journal of Physiology - Heart and Circulatory Physiology. 281. PMID 11557573 |
0.388 |
|
| 2001 |
Cazorla O, Wu Y, Irving TC, Granzier H. Titin-based modulation of calcium sensitivity of active tension in mouse skinned cardiac myocytes Circulation Research. 88: 1028-1035. PMID 11375272 DOI: 10.1161/Hh1001.090876 |
0.417 |
|
| 2001 |
Bang ML, Mudry RE, McElhinny AS, Trombitás K, Geach AJ, Yamasaki R, Sorimachi H, Granzier H, Gregorio CC, Labeit S. Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies Journal of Cell Biology. 153: 413-427. PMID 11309420 DOI: 10.1083/Jcb.153.2.413 |
0.5 |
|
| 2001 |
Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. Journal of Molecular Biology. 306: 717-26. PMID 11243782 DOI: 10.1006/Jmbi.2001.4448 |
0.426 |
|
| 2001 |
Kellermayer MS, Smith SB, Bustamante C, Granzier HL. Mechanical fatigue in repetitively stretched single molecules of titin. Biophysical Journal. 80: 852-63. PMID 11159452 DOI: 10.1016/S0006-3495(01)76064-X |
0.325 |
|
| 2000 |
Wu Y, Cazorla O, Labeit D, Labeit S, Granzier H. Changes in titin and collagen underlie diastolic stiffness diversity of cardiac muscle Journal of Molecular and Cellular Cardiology. 32: 2151-2161. PMID 11112991 DOI: 10.1006/Jmcc.2000.1281 |
0.644 |
|
| 2000 |
Trombitás K, Redkar A, Centner T, Wu Y, Labeit S, Granzier H. Extensibility of isoforms of cardiac titin: Variation in contour length of molecular subsegments provides a basis for cellular passive stiffness diversity Biophysical Journal. 79: 3226-3234. PMID 11106626 DOI: 10.1016/S0006-3495(00)76555-6 |
0.415 |
|
| 2000 |
Trombitás K, Freiburg A, Greaser M, Labeit S, Granzier H. From connecting filaments to co-expression of titin isoforms Advances in Experimental Medicine and Biology. 481: 405-418. PMID 10987086 DOI: 10.1007/978-1-4615-4267-4_24 |
0.447 |
|
| 2000 |
Granzier H, Helmes M, Cazorla O, McNabb M, Labeit D, Wu Y, Yamasaki R, Redkar A, Kellermayer M, Labeit S, Trombitás K, TerKeurs, Linke, Trinick, Andrew. Mechanical properties of titin isoforms Advances in Experimental Medicine and Biology. 481: 283-304. PMID 10987079 DOI: 10.1007/978-1-4615-4267-4_17 |
0.621 |
|
| 2000 |
Kellermayer MS, Smith S, Bustamante C, Granzier HL. Mechanical manipulation of single titin molecules with laser tweezers. Advances in Experimental Medicine and Biology. 481: 111-26; discussion 1. PMID 10987069 DOI: 10.1007/978-1-4615-4267-4_7 |
0.312 |
|
| 2000 |
Centner T, Fougerousse F, Freiburg A, Witt C, Beckmann JS, Granzier H, Trombitás K, Gregorio CC, Labeit S, Greaser, Bullard, Linke, Pollack, Trinick. Molecular tools for the study of titin's differential expression Advances in Experimental Medicine and Biology. 481: 35-52. PMID 10987065 DOI: 10.1007/978-1-4615-4267-4_3 |
0.374 |
|
| 2000 |
Bell SP, Nyland L, Tischler MD, McNabb M, Granzier H, LeWinter MM. Alterations in the determinants of diastolic suction during pacing tachycardia Circulation Research. 87: 235-240. PMID 10926875 DOI: 10.1161/01.Res.87.3.235 |
0.343 |
|
| 2000 |
Freiburg A, Trombitas K, Hell W, Cazorla O, Fougerousse F, Centner T, Kolmerer B, Witt C, Beckmann JS, Gregorio CC, Granzier H, Labeit S. Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity Circulation Research. 86: 1114-1121. PMID 10850961 DOI: 10.1161/01.Res.86.11.1114 |
0.542 |
|
| 2000 |
Cazorla O, Freiburg A, Helmes M, Centner T, McNabb M, Wu Y, Trombitás K, Labeit S, Granzier H. Differential expression of cardiac titin isoforms and modulation of cellular stiffness Circulation Research. 86: 59-67. PMID 10625306 DOI: 10.1161/01.Res.86.1.59 |
0.44 |
|
| 1999 |
Trombitás K, Freiburg A, Centner T, Labeit S, Granzier H. Molecular dissection of N2B cardiac titin's extensibility Biophysical Journal. 77: 3189-3196. PMID 10585940 DOI: 10.1016/S0006-3495(99)77149-3 |
0.413 |
|
| 1999 |
Helmes M, Trombitás K, Centner T, Kellermayer M, Labeit S, Linke WA, Granzier H. Mechanically driven contour-length adjustment in rat cardiac titin's unique N2B sequence. Titin is an adjustable spring Circulation Research. 84: 1339-1352. PMID 10364572 DOI: 10.1161/01.Res.84.11.1339 |
0.377 |
|
| 1999 |
Ogut O, Granzier H, Jin JP. Acidic and basic troponin T isoforms in mature fast-twitch skeletal muscle and effect on contractility. The American Journal of Physiology. 276: C1162-70. PMID 10329966 DOI: 10.1152/Ajpcell.1999.276.5.C1162 |
0.607 |
|
| 1999 |
Gregorio CC, Granzier H, Sorimachi H, Labeit S. Muscle assembly: A titanic achievement? Current Opinion in Cell Biology. 11: 18-25. PMID 10047523 DOI: 10.1016/S0955-0674(99)80003-9 |
0.488 |
|
| 1998 |
Gregorio CC, Trombitás K, Centner T, Kolmerer B, Stier G, Kunke K, Suzuki K, Obermayr F, Herrmann B, Granzier H, Sorimachi H, Labeit S. The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity. The Journal of Cell Biology. 143: 1013-27. PMID 9817758 DOI: 10.1083/Jcb.143.4.1013 |
0.359 |
|
| 1998 |
Millevoi S, Trombitas K, Kolmerer B, Kostin S, Schaper J, Pelin K, Granzier H, Labeit S. Characterization of nebulette and nebulin and emerging concepts of their roles for vertebrate Z-discs Journal of Molecular Biology. 282: 111-123. PMID 9733644 DOI: 10.1006/Jmbi.1998.1999 |
0.488 |
|
| 1998 |
Trombitás K, Greaser M, French G, Granzier H. PEVK extension of human soleus muscle titin revealed by immunolabeling with the anti-titin antibody 9D10 Journal of Structural Biology. 122: 188-196. PMID 9724620 DOI: 10.1006/Jsbi.1998.3984 |
0.479 |
|
| 1997 |
Spierts IL, Akster HA, Granzier HL. Expression of titin isoforms in red and white muscle fibres of carp (Cyprinus carpio L.) exposed to different sarcomere strains during swimming. Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology. 167: 543-51. PMID 9404015 DOI: 10.1007/s003600050107 |
0.489 |
|
| 1997 |
Granzier H, Kellermayer M, Helmes M, Trombitás K. Titin elasticity and mechanism of passive force development in rat cardiac myocytes probed by thin-filament extraction Biophysical Journal. 73: 2043-2053. PMID 9336199 DOI: 10.1016/S0006-3495(97)78234-1 |
0.433 |
|
| 1997 |
Trombitás K, Granzier H. Actin removal from cardiac myocytes shows that near Z line titin attaches to actin while under tension American Journal of Physiology - Cell Physiology. 273. PMID 9277364 DOI: 10.1152/Ajpcell.1997.273.2.C662 |
0.342 |
|
| 1997 |
Kellermayer MSZ, Smith SB, Granzier HL, Bustamante C. Folding-unfolding transitions in single titin molecules characterized with laser tweezers Science. 276: 1112-1116. PMID 9148805 DOI: 10.1126/Science.276.5315.1112 |
0.333 |
|
| 1996 |
Helmes M, Trombitás K, Granzier H. Titin develops restoring force in rat cardiac myocytes Circulation Research. 79: 619-626. PMID 8781495 DOI: 10.1161/01.Res.79.3.619 |
0.405 |
|
| 1996 |
Granzier H, Helmes M, Trombitás K. Nonuniform elasticity of titin in cardiac myocytes: A study using immunoelectron microscopy and cellular mechanics Biophysical Journal. 70: 430-442. PMID 8770219 DOI: 10.1016/S0006-3495(96)79586-3 |
0.47 |
|
| 1996 |
Kellermayer MS, Granzier HL. Elastic properties of single titin molecules made visible through fluorescent F-actin binding. Biochemical and Biophysical Research Communications. 221: 491-7. PMID 8629989 DOI: 10.1006/bbrc.1996.0624 |
0.303 |
|
| 1996 |
Kellermayer MS, Granzier HL. Calcium-dependent inhibition of in vitro thin-filament motility by native titin. Febs Letters. 380: 281-6. PMID 8601441 DOI: 10.1016/0014-5793(96)00055-5 |
0.355 |
|
| 1995 |
Granzier HL, Irving TC. Passive tension in cardiac muscle: Contribution of collagen, titin, microtubules, and intermediate filaments Biophysical Journal. 68: 1027-1044. PMID 7756523 |
0.524 |
|
| 1995 |
Trombitas K, Jin JP, Granzier H. The mechanically active domain of titin in cardiac muscle Circulation Research. 77: 856-861. PMID 7554133 DOI: 10.1161/01.Res.77.4.856 |
0.419 |
|
| 1993 |
Granzier HLM, Wang K. Gel electrophoresis of giant proteins: Solubilization and silver-staining of titin and nebulin from single muscle fiber segments Electrophoresis. 14: 56-64. PMID 8462516 |
0.414 |
|
| 1993 |
Granzier HLM, Wang K. Passive tension and stiffness of vertebrate skeletal and insect flight muscles: The contribution of weak cross-bridges and elastic filaments Biophysical Journal. 65: 2141-2159. PMID 8298040 |
0.538 |
|
| 1993 |
Granzier HLM, Wang K. Interplay between passive tension and strong and weak binding cross-bridges in insect indirect flight muscle: A functional dissection by gelsolin-mediated thin filament removal Journal of General Physiology. 101: 235-270. PMID 7681097 |
0.45 |
|
| 1991 |
Granzier HLM, Akster HA, Ter Keurs HEDJ. Effect of thin filament length on the force-sarcomere length relation of skeletal muscle American Journal of Physiology - Cell Physiology. 260. PMID 2035614 |
0.303 |
|
| 1990 |
Granzier HL, Pollack GH. The descending limb of the force‐sarcomere length relation of the frog revisited The Journal of Physiology. 421: 595-615. PMID 2348405 DOI: 10.1113/jphysiol.1990.sp017964 |
0.327 |
|
| 1989 |
Granzier HLM, Burns DH, Pollack GH. Sarcomere length dependence of the force-velocity relation in single frog muscle fibers Biophysical Journal. 55: 499-507. PMID 2784695 |
0.425 |
|
| 1989 |
Granzier HL, Pollack GH. Effect of active pre‐shortening on isometric and isotonic performance of single frog muscle fibres The Journal of Physiology. 415: 299-327. PMID 2640463 DOI: 10.1113/jphysiol.1989.sp017723 |
0.3 |
|
| 1989 |
Akster HA, Granzier HLM, Focant B. Differences in I band structure, sarcomere extensibility, and electrophoresis of titin between two muscle fiber types of the perch (Perca fluviatilis L.) Journal of Ultrastructure Research and Molecular Structure Research. 102: 109-121. DOI: 10.1016/0889-1605(89)90048-7 |
0.308 |
|
| 1988 |
Pollack GH, Granzier HL, Mattiazzi A, Trombitás C, Periasamy A, Baatsen PH, Burns DH. Pauses, steps, and the mechanism of contraction Advances in Experimental Medicine and Biology. 226: 617-642. PMID 3407536 |
0.442 |
|
| 1987 |
Granzier HLM, Myers JA, Pollack GH. Stepwise shortening of muscle fibre segments Journal of Muscle Research and Cell Motility. 8: 242-251. PMID 3497174 DOI: 10.1007/BF01574592 |
0.398 |
|
| 1985 |
Granzier HL, Pollack GH. Stepwise shortening in unstimulated frog skeletal muscle fibres The Journal of Physiology. 362: 173-188. PMID 3874953 DOI: 10.1113/jphysiol.1985.sp015669 |
0.363 |
|
| 1985 |
Akster HA, Granzier HL, ter Keurs HE. A comparison of quantitative ultrastructural and contractile characteristics of muscle fibre types of the perch, Perca fluviatilis L. Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology. 155: 685-91. PMID 3837036 DOI: 10.1007/BF00694582 |
0.398 |
|
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