Kivanc birsoy - Publications

Affiliations: 
Whitehead Institute, Cambridge, MA, United States 

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Timson RC, Khan A, Uygur B, Saad M, Yeh HW, DelGaudio NL, Weber R, Alwaseem H, Gao J, Yang C, Birsoy K. Development of a mouse model expressing a bifunctional glutathione synthesizing enzyme to study glutathione limitation in vivo. The Journal of Biological Chemistry. 105645. PMID 38218225 DOI: 10.1016/j.jbc.2024.105645  0.316
2022 Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato R. Author Correction: NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. Nature. 609: E12. PMID 36104569 DOI: 10.1038/s41586-022-05323-7  0.433
2022 Garcia-Bermudez J, Badgley MA, Prasad S, Baudrier L, Liu Y, La K, Soula M, Williams RT, Yamaguchi N, Hwang RF, Taylor LJ, de Stanchina E, Rostandy B, Alwaseem H, Molina H, ... ... Birsoy K, et al. Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia. Nature Metabolism. PMID 35726024 DOI: 10.1038/s42255-022-00583-z  0.308
2020 Parsa S, Ortega-Molina A, Ying HY, Jiang M, Teater M, Wang J, Zhao C, Reznik E, Pasion JP, Kuo D, Mohan P, Wang S, Camarillo JM, Thomas PM, Jain N, ... ... Birsoy K, et al. The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing. Nature Cancer. 1: 653-664. PMID 33569544 DOI: 10.1038/s43018-020-0080-0  0.43
2020 Zhu XG, Chudnovskiy A, Baudrier L, Prizer B, Liu Y, Ostendorf BN, Yamaguchi N, Arab A, Tavora B, Timson R, Heissel S, de Stanchina E, Molina H, Victora GD, Goodarzi H, ... Birsoy K, et al. Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells. Cell Metabolism. PMID 33152324 DOI: 10.1016/j.cmet.2020.10.017  0.335
2020 Soula M, Weber RA, Zilka O, Alwaseem H, La K, Yen F, Molina H, Garcia-Bermudez J, Pratt DA, Birsoy K. Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers. Nature Chemical Biology. PMID 32778843 DOI: 10.1038/S41589-020-0613-Y  0.409
2020 Hedbacker K, Lu YH, Dallner O, Li Z, Fayzikhodjaeva G, Birsoy K, Han C, Yang C, Friedman JM. Limitation of adipose tissue by the number of embryonic progenitor cells. Elife. 9. PMID 32452759 DOI: 10.7554/Elife.53074  0.521
2020 Surface LE, Burrow DT, Li J, Park J, Kumar S, Lyu C, Song N, Yu Z, Rajagopal A, Bae Y, Lee BH, Mumm S, Gu CC, Baker JC, Mohseni M, ... ... Birsoy K, et al. regulates the action of nitrogen-containing bisphosphonates on bone. Science Translational Medicine. 12. PMID 32434850 DOI: 10.1126/Scitranslmed.Aav9166  0.506
2020 Williams RT, Guarecuco R, Gates LA, Barrows D, Passarelli MC, Carey B, Baudrier L, Jeewajee S, La K, Prizer B, Malik S, Garcia-Bermudez J, Zhu XG, Cantor J, Molina H, ... ... Birsoy K, et al. ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase. Cell Metabolism. 31: 852-861.e6. PMID 32268116 DOI: 10.1016/J.Cmet.2020.03.008  0.521
2020 Weber RA, Yen FS, Nicholson SPV, Alwaseem H, Bayraktar EC, Alam M, Timson RC, La K, Abu-Remaileh M, Molina H, Birsoy K. Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation. Molecular Cell. PMID 31983508 DOI: 10.1016/J.Molcel.2020.01.003  0.704
2020 Hedbacker K, Lu Y, Dallner O, Li Z, Fayzikhodjaeva G, Birsoy K, Han C, Yang C, Friedman JM. Author response: Limitation of adipose tissue by the number of embryonic progenitor cells Elife. DOI: 10.7554/Elife.53074.Sa2  0.517
2019 Garcia-Bermudez J, Williams RT, Guarecuco R, Birsoy K. Targeting extracellular nutrient dependencies of cancer cells. Molecular Metabolism. PMID 31926876 DOI: 10.1016/J.Molmet.2019.11.011  0.432
2019 Weber R, Birsoy K. The Transsulfuration Pathway Makes, the Tumor Takes. Cell Metabolism. 30: 845-846. PMID 31693878 DOI: 10.1016/J.Cmet.2019.10.009  0.345
2019 Zhu XG, Birsoy K. Deciphering cellular heterogeneity of pancreatic tumours. Nature Cell Biology. 21: 1305-1306. PMID 31685993 DOI: 10.1038/S41556-019-0419-X  0.342
2019 Phillips RE, Yang Y, Smith RC, Thompson BM, Yamasaki T, Soto-Feliciano YM, Funato K, Liang Y, Garcia-Bermudez J, Wang X, Garcia BA, Yamasaki K, McDonald JG, Birsoy K, Tabar V, et al. Target identification reveals lanosterol synthase as a vulnerability in glioma. Proceedings of the National Academy of Sciences of the United States of America. PMID 30923116 DOI: 10.1073/Pnas.1820989116  0.346
2019 Birsoy K, Sancak Y. The role of metabolism in cellular processes. Molecular Biology of the Cell. 30: 733. PMID 30870095 DOI: 10.1091/Mbc.E19-01-0004  0.327
2019 Zhu XG, Nicholson Puthenveedu S, Shen Y, La K, Ozlu C, Wang T, Klompstra D, Gultekin Y, Chi J, Fidelin J, Peng T, Molina H, Hang HC, Min W, Birsoy K. CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4. Molecular Cell. PMID 30846317 DOI: 10.1016/J.Molcel.2019.01.037  0.387
2019 Dallner OS, Marinis JM, Lu YH, Birsoy K, Werner E, Fayzikhodjaeva G, Dill BD, Molina H, Moscati A, Kutalik Z, Marques-Vidal P, Kilpeläinen TO, Grarup N, Linneberg A, Zhang Y, et al. Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity. Nature Medicine. PMID 30842678 DOI: 10.1038/S41591-019-0370-1  0.495
2019 Garcia-Bermudez J, Baudrier L, Bayraktar EC, Shen Y, La K, Guarecuco R, Yucel B, Fiore D, Tavora B, Freinkman E, Chan SH, Lewis C, Min W, Inghirami G, Sabatini DM, ... Birsoy K, et al. Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature. PMID 30760928 DOI: 10.1038/S41586-019-0945-5  0.596
2018 Bayraktar EC, Baudrier L, Özerdem C, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Cangelosi AL, Sabatini DM, Birsoy K, Chen WW. MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 30541894 DOI: 10.1073/Pnas.1816656115  0.748
2018 Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K. Publisher Correction: Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. Nature Cell Biology. PMID 30089842 DOI: 10.1038/S41556-018-0184-2  0.332
2018 Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K. Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. Nature Cell Biology. PMID 29941933 DOI: 10.1038/S41556-018-0118-Z  0.431
2018 Zhang M, Di Martino JS, Bowman RL, Campbell NR, Baksh SC, Simon-Vermot T, Kim IS, Haldeman P, Mondal C, Yong-Gonzalez V, Abu-Akeel M, Merghoub T, Jones DR, Zhu XG, Arora A, ... ... Birsoy K, et al. Adipocyte-derived lipids mediate melanoma progression via FATP proteins. Cancer Discovery. PMID 29903879 DOI: 10.1158/2159-8290.Cd-17-1371  0.367
2018 Peng X, Chen Z, Farshidfar F, Xu X, Lorenzi PL, Wang Y, Cheng F, Tan L, Mojumdar K, Du D, Ge Z, Li J, Thomas GV, Birsoy K, Liu L, et al. Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers. Cell Reports. 23: 255-269.e4. PMID 29617665 DOI: 10.1016/J.Celrep.2018.03.077  0.392
2018 Minton DR, Nam M, McLaughlin DJ, Shin J, Bayraktar EC, Alvarez SW, Sviderskiy VO, Papagiannakopoulos T, Sabatini DM, Birsoy K, Possemato R. Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs. Molecular Cell. 69: 610-621.e5. PMID 29452640 DOI: 10.1016/J.Molcel.2018.01.024  0.573
2018 Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato RL. Abstract NG02: NFS1 undergoes positive selection in lung tumors and protects cells from ferroptosis Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Ng02  0.586
2017 Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato R. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. Nature. PMID 29168506 DOI: 10.1038/Nature24637  0.573
2017 Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, Sabatini DM, Chandel NS. A CRISPR screen identifies a pathway required for paraquat-induced cell death. Nature Chemical Biology. PMID 29058724 DOI: 10.1038/Nchembio.2499  0.551
2017 Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, et al. PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396387 DOI: 10.1073/Pnas.1617922114  0.772
2017 Secco B, Camiré É, Brière MA, Caron A, Billong A, Gélinas Y, Lemay AM, Tharp KM, Lee PL, Gobeil S, Guimond JV, Patey N, Guertin DA, Stahl A, Haddad É, ... ... Birsoy K, et al. Amplification of Adipogenic Commitment by VSTM2A. Cell Reports. 18: 93-106. PMID 28052263 DOI: 10.1016/J.Celrep.2016.12.015  0.661
2016 Garcia-Bermudez J, Birsoy K. Drugging ACAT1 for Cancer Therapy. Molecular Cell. 64: 856-857. PMID 27912096 DOI: 10.1016/J.Molcel.2016.11.023  0.302
2016 Chen WW, Freinkman E, Wang T, Birsoy K, Sabatini DM. Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism. Cell. 166: 1324-1337.e11. PMID 27565352 DOI: 10.1016/J.Cell.2016.07.040  0.559
2016 Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu MR, Shaul YD, et al. Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology. 12: 656. PMID 27434767 DOI: 10.1038/Nchembio0816-656  0.676
2016 Chidley C, Trauger SA, Birsoy K, O'Shea EK. The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine. Elife. 5. PMID 27403889 DOI: 10.7554/Elife.14601  0.362
2016 Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology. PMID 27110680 DOI: 10.1038/Nchembio.2070  0.759
2015 Wang T, Birsoy K, Hughes NW, Krupczak KM, Post Y, Wei JJ, Lander ES, Sabatini DM. Identification and characterization of essential genes in the human genome. Science (New York, N.Y.). PMID 26472758 DOI: 10.1126/Science.Aac7041  0.553
2015 Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM. Corrigendum to "Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression"[Mol Metab 4 (2015) 392-405]. Molecular Metabolism. 4: 592. PMID 26266092 DOI: 10.1016/J.Molmet.2015.05.004  0.459
2015 Birsoy K, Wang T, Chen WW, Freinkman E, Abu-Remaileh M, Sabatini DM. An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis. Cell. 162: 540-551. PMID 26232224 DOI: 10.1016/J.Cell.2015.07.016  0.751
2015 Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM. Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression. Molecular Metabolism. 4: 392-405. PMID 25973387 DOI: 10.1016/J.Molmet.2015.02.002  0.506
2015 Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, et al. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 520: 363-7. PMID 25855294 DOI: 10.1038/Nature14363  0.761
2015 Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM. Corrigendum to "Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression"[Mol Metab 4 (2015) 392-405] Molecular Metabolism. DOI: 10.1016/j.molmet.2015.05.004  0.388
2014 Knight ZA, Schmidt SF, Birsoy K, Tan K, Friedman JM. A critical role for mTORC1 in erythropoiesis and anemia. Elife. 3: e01913. PMID 25201874 DOI: 10.7554/Elife.01913  0.701
2014 Chen WW, Birsoy K, Mihaylova MM, Snitkin H, Stasinski I, Yucel B, Bayraktar EC, Carette JE, Clish CB, Brummelkamp TR, Sabatini DD, Sabatini DM. Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells. Cell Reports. 7: 27-34. PMID 24685140 DOI: 10.1016/J.Celrep.2014.02.046  0.545
2014 Birsoy K, Possemato R, Lorbeer FK, Bayraktar EC, Thiru P, Yucel B, Wang T, Chen WW, Clish CB, Sabatini DM. Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature. 508: 108-12. PMID 24670634 DOI: 10.1038/Nature13110  0.6
2014 Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM. A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discovery. 4: 554-63. PMID 24631838 DOI: 10.1158/2159-8290.CD-13-0929  0.608
2014 Soliman MA, Abdel Rahman AM, Lamming DW, Lamming DA, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T. The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism. Science Signaling. 7: ra17. PMID 24550542 DOI: 10.1126/Scisignal.2004785  0.713
2014 Knight ZA, Schmidt SF, Birsoy K, Tan K, Friedman JM. Author response: A critical role for mTORC1 in erythropoiesis and anemia Elife. DOI: 10.7554/Elife.01913.013  0.644
2014 Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T. A correction to the research article titled: "The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism" (Science Signaling (2014)) Science Signaling. 7. DOI: 10.1126/scisignal.7315er2  0.465
2013 Birsoy K, Festuccia WT, Laplante M. A comparative perspective on lipid storage in animals. Journal of Cell Science. 126: 1541-52. PMID 23658371 DOI: 10.1242/Jcs.104992  0.644
2013 Birsoy K, Wang T, Possemato R, Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y, Peterson TR, Carette JE, Brummelkamp TR, Clish CB, Sabatini DM. MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. Nature Genetics. 45: 104-8. PMID 23202129 DOI: 10.1038/Ng.2471  0.686
2012 Knight ZA, Tan K, Birsoy K, Schmidt S, Garrison JL, Wysocki RW, Emiliano A, Ekstrand MI, Friedman JM. Molecular profiling of activated neurons by phosphorylated ribosome capture. Cell. 151: 1126-37. PMID 23178128 DOI: 10.1016/J.Cell.2012.10.039  0.658
2012 Laplante M, Horvat S, Festuccia WT, Birsoy K, Prevorsek Z, Efeyan A, Sabatini DM. DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity. Cell Metabolism. 16: 202-12. PMID 22883231 DOI: 10.1016/J.Cmet.2012.07.008  0.71
2012 Birsoy K, Sabatini DM, Possemato R. Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson. Nature Medicine. 18: 1022-3. PMID 22772555 DOI: 10.1038/Nm.2870  0.561
2012 Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature. 486: 490-5. PMID 22722868 DOI: 10.1038/Nature11163  0.69
2012 Ceyhan O, Birsoy K, Hoffman CS. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chemistry & Biology. 19: 155-63. PMID 22284362 DOI: 10.1016/J.Chembiol.2011.12.010  0.311
2011 Birsoy K, Berry R, Wang T, Ceyhan O, Tavazoie S, Friedman JM, Rodeheffer MS. Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis. Development (Cambridge, England). 138: 4709-19. PMID 21989915 DOI: 10.1242/Jcs.101436  0.535
2011 Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 476: 346-50. PMID 21760589 DOI: 10.1038/Nature10350  0.747
2010 Chen W, Zhang X, Birsoy K, Roeder RG. A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism. Proceedings of the National Academy of Sciences of the United States of America. 107: 10196-201. PMID 20479251 DOI: 10.1073/Pnas.1005626107  0.509
2010 Hedbacker K, Birsoy K, Wysocki RW, Asilmaz E, Ahima RS, Farooqi IS, Friedman JM. Antidiabetic effects of IGFBP2, a leptin-regulated gene. Cell Metabolism. 11: 11-22. PMID 20074524 DOI: 10.1016/J.Cmet.2009.11.007  0.503
2010 Hedbacker K, Birsoy K, Wysocki RW, Asilmaz E, Ahima RS, Farooqi IS, Friedman JM. Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene (DOI:10.1016/j.cmet.2009.11.007) Cell Metabolism. 11: 239. DOI: 10.1016/J.Cmet.2010.02.010  0.47
2008 Rodeheffer MS, Birsoy K, Friedman JM. Identification of white adipocyte progenitor cells in vivo. Cell. 135: 240-9. PMID 18835024 DOI: 10.1016/J.Cell.2008.09.036  0.532
2008 Birsoy K, Soukas A, Torrens J, Ceccarini G, Montez J, Maffei M, Cohen P, Fayzikhodjaeva G, Viale A, Socci ND, Friedman JM. Cellular program controlling the recovery of adipose tissue mass: An in vivo imaging approach. Proceedings of the National Academy of Sciences of the United States of America. 105: 12985-90. PMID 18753616 DOI: 10.1073/Pnas.0805621105  0.736
2008 Birsoy K, Chen Z, Friedman J. Transcriptional regulation of adipogenesis by KLF4. Cell Metabolism. 7: 339-47. PMID 18396140 DOI: 10.1016/J.Cmet.2008.02.001  0.487
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